Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulatory subunit binding

PTPN13 DNM2

1.83e-0414292GO:0036312
DomainDEAD

DDX46 DHX38

5.71e-0373292PF00270
DomainDEAD/DEAH_box_helicase_dom

DDX46 DHX38

5.71e-0373292IPR011545
DomainHelicase_C

DDX46 DHX38

1.19e-02107292PF00271
DomainHELICc

DDX46 DHX38

1.19e-02107292SM00490
DomainHelicase_C

DDX46 DHX38

1.21e-02108292IPR001650
DomainHELICASE_CTER

DDX46 DHX38

1.24e-02109292PS51194
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

STK39 DDX46 EIF3J LEO1 RBBP6 DHX38 DNM2

8.68e-0765329733742100
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

CCNH CACTIN DDX46 LEO1 RBBP6 CANX

3.29e-0650629630890647
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ALMS1 LEO1 RNASEH2A RBBP6 CANX DHX38

7.77e-0658829638580884
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

AASDHPPT PTPN13 DDX46 ALMS1 RBBP6 DHX38 DNM2

9.17e-0693429733916271
Pubmed

A bead-based approach for large-scale identification of in vitro kinase substrates.

EIF3J LEO1 CANX DHX38

1.01e-0516329422113938
Pubmed

Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk.

CCNH ERCC5

1.41e-05729216492920
Pubmed

Nucleotide excision repair pathway genes and oral premalignant lesions.

CCNH ERCC5

1.41e-05729217575242
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CCNH CACTIN DDX46 EIF3J LEO1 RBBP6 DHX38

1.56e-05101429732416067
Pubmed

Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway.

CCNH ERCC5

1.87e-05829219270000
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

CACTIN DDX46 ERCC5 LEO1 RBBP6 DNM2

3.66e-0577429615302935
Pubmed

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.

CCNH ERCC5

3.68e-051129211259578
Pubmed

A transcript finishing initiative for closing gaps in the human transcriptome.

CACTIN RIPOR3

3.68e-051129215197164
Pubmed

Genome-wide association study of panic disorder in the Japanese population.

ANO2 CALCOCO1

5.21e-051329219165232
Pubmed

Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.

CCNH ERCC5

7.00e-051529218854777
Pubmed

Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.

CCNH ERCC5

8.00e-051629211313499
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

CACTIN AASDHPPT DDX46 RBBP6 CANX DHX38 DNM2

8.28e-05131829730463901
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

CACTIN DDX46 RBBP6 DHX38

8.68e-0528329430585729
Pubmed

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.

ERCC5 DMXL1 DNM2 CALCOCO1

8.68e-0528329418854154
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CCNH ERCC5 EIF3J LEO1 CANX DNM2

8.96e-0591029636736316
Pubmed

Functional proteomics mapping of a human signaling pathway.

RLF CCDC181 RBBP6 CANX DNM2

1.18e-0459129515231748
Pubmed

DNA damage recognition during nucleotide excision repair in mammalian cells.

CCNH ERCC5

1.26e-042029210214908
Pubmed

Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.

EIF3J CEP112 CANX DMXL1

1.55e-0432929434316702
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

CCNH CACTIN PTPN13 LEO1 CANX DHX38

1.94e-04104929627880917
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

RLF DDX46 RBBP6 CALCOCO1

2.21e-0436129426167880
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

PTPN13 ERCC5 CEP112 DHX38 DNM2 LRRC17

2.32e-04108429611544199
Pubmed

Quality control by DNA repair.

CCNH ERCC5

2.50e-042829210583946
Pubmed

The protein interaction landscape of the human CMGC kinase group.

CCNH DDX46 ERCC5 ALMS1 RBBP6

2.51e-0469529523602568
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

CCNH DDX46 ERCC5 DNM2

2.96e-0439029417643375
Pubmed

Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.

RLF RBBP6

3.70e-043429225505242
Pubmed

A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.

CCNH ERCC5

4.39e-043729219116388
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

CACTIN DDX46 RBBP6 CANX DHX38

4.97e-0480729522681889
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

CACTIN EIF3J ALMS1 RBBP6

5.94e-0446929427634302
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

CACTIN ZNF845 DDX46 LEO1 RBBP6 DHX38

5.97e-04129429630804502
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

DDX46 ERCC5 CANX DNM2

6.52e-0448129428190767
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

STK39 EIF3J LEO1 RBBP6

7.71e-0450329416964243
InteractionEZH1 interactions

CACTIN DDX46 RBBP6 DHX38

8.85e-0692294int:EZH1
InteractionDHX40 interactions

RLF CACTIN ERCC5 RBBP6 DHX38

2.58e-05249295int:DHX40
CytobandEnsembl 112 genes in cytogenetic band chr2q24

CD302 STK39

2.94e-03127292chr2q24
CytobandEnsembl 112 genes in cytogenetic band chr15q21

EIF3J LEO1

5.60e-03177292chr15q21
Cytoband19p13.2

RNASEH2A DNM2

9.20e-0322929219p13.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CACTIN RNASEH2A DNM2

1.36e-02797293chr19p13
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

RLF CCNH PTPN13 DDX46 ERCC5 EIF3J CEP112 DMXL1

3.98e-07656298M18979
CoexpressionPARK_HSC_MARKERS

CCNH RBBP6 DMXL1

1.56e-0544293M6509
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_A

ERCC5 CANX DMXL1 RIC3

5.98e-05194294M2517
CoexpressionGSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_DN

RLF CD302 DDX46 CALCOCO1

6.60e-05199294M4310
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_A

ERCC5 CANX DMXL1 RIC3

8.13e-05210294MM958
CoexpressionKYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION

CCNH ERCC5 RBBP6

8.43e-0577293M2540
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#3_top-relative-expression-ranked_500

RLF STK39 DMXL1

3.13e-0545293gudmap_developingGonad_e16.5_epididymis_500_k3
CoexpressionAtlasFacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1

RLF ZNF845 DDX46 ALMS1 DHX38 DMXL1

3.47e-05469296Facebase_RNAseq_e8.5_Floor Plate_2500_K1
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

RLF ZNF845 DDX46 ALMS1 LEO1 DHX38

6.99e-05532296Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
Diseasealpha globulin measurement, protein measurement

CEP112 DHX38

5.20e-064282EFO_0004747, EFO_0004813
Diseasepanic disorder

ANO2 CALCOCO1

4.50e-0433282EFO_0004262
Diseasephysical activity

ANO2 RBBP6

3.16e-0388282EFO_0003940

Protein segments in the cluster

PeptideGeneStartEntry
DGEEEKEWAFEESKI

AASDHPPT

221

Q9NRN7
KSKHEEEEWTDDDLV

CCNH

306

P51946
TFDKWTDQDDDEDLV

CD302

111

Q8IX05
ESIDDEEDEEAKAWL

ALMS1

66

Q8TCU4
EEEKWEKLDAEFDHF

CEP112

6

Q8N8E3
ECGDEDDEDKLTWKD

ANO2

516

Q9NQ90
DDSLELKWDSDNDEE

DMXL1

1961

Q9Y485
DDEKWGREDKSDQSD

LEO1

141

Q8WVC0
TRWKKDLAEDEEEED

IFNLR1

316

Q8IU57
EDVKDNWDDDDDEKK

EIF3J

46

O75822
NWDDDDDEKKEEAEV

EIF3J

51

O75822
SFDQDTEDDEWEKKH

LRRC17

411

Q8N6Y2
EETTKEEWSQDFKDE

RIC3

331

Q7Z5B4
TAESLSWYKDEEEKE

DNM2

546

P50570
WDKDDFESEEEDVKS

RBBP6

1321

Q7Z6E9
KSEEYEDDFEKDLEW

CCDC181

11

Q5TID7
DDTDDEIAKYDGKWE

CANX

91

P27824
EKEAEHFKTWEEQED

CACTIN

271

Q8WUQ7
KKWSLEDDDDDEDDP

DDX46

196

Q7L014
ADEKWNEDATTEDEE

CALCOCO1

511

Q9P1Z2
EKKTDDDEITWGNDE

PTPN13

2141

Q12923
EKEAEDVIWEDSASE

RNASEH2A

246

O75792
VKQWDHSEDEKETDE

ODAD4

536

Q96NG3
EEEKHSSEEEDEKEW

ERCC5

151

P28715
EKDIHDFEFQWKEDE

ZNF845

91

Q96IR2
FIQESEEKEDDFDDW

RLF

1776

Q13129
ESDDSQTWDEEEKAF

RIPOR3

241

Q96MK2
NVSSFEWVKDEEDED

PREPL

201

Q4J6C6
DWEESKDDQKDAEEE

DHX38

81

Q92620
DWEWSDDEMDEKSEE

STK39

381

Q9UEW8