Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RNF8 SHPRH RC3H2 ZMIZ1 RNF148 ZNF451 HECTD4	2.07e-04	512	48	7	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	RNF8 SHPRH RC3H2 ZMIZ1 RNF148 ZNF451 HECTD4	2.62e-04	532	48	7	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RNF8 SHPRH RC3H2 ZMIZ1 RNF148 ZNF451	3.65e-04	398	48	6	GO:0061659
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	PAXIP1 RNF8 SHPRH RC3H2 CAND1 ZMIZ1 KBTBD6 PRICKLE1 KBTBD7 ZNF451 HECTD4	4.89e-06	893	48	11	GO:0032446
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	PAXIP1 RNF8 SHPRH RC3H2 CAND1 ZMIZ1 KBTBD6 PRICKLE1 KBTBD7 ZNF451 HECTD4	1.55e-05	1009	48	11	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	PAXIP1 RNF8 SHPRH RC3H2 CAND1 ZMIZ1 KBTBD6 PRICKLE1 KBTBD7 ZNF451 HECTD4	2.77e-05	1074	48	11	GO:0043687
GeneOntologyBiologicalProcess	regulation of transcription initiation by RNA polymerase II	PAXIP1 CAND1 MED29 ZNF451	3.77e-05	81	48	4	GO:0060260
GeneOntologyBiologicalProcess	negative regulation of DNA replication	LIG3 PDS5A TIMELESS	4.14e-05	29	48	3	GO:0008156
GeneOntologyBiologicalProcess	regulation of DNA-templated transcription initiation	PAXIP1 CAND1 MED29 ZNF451	5.95e-05	91	48	4	GO:2000142
GeneOntologyBiologicalProcess	transcription initiation at RNA polymerase II promoter	PAXIP1 CAND1 ATAD2 MED29 ZNF451	7.07e-05	186	48	5	GO:0006367
GeneOntologyBiologicalProcess	protein ubiquitination	PAXIP1 RNF8 SHPRH RC3H2 CAND1 KBTBD6 PRICKLE1 KBTBD7 HECTD4	9.08e-05	811	48	9	GO:0016567
GeneOntologyBiologicalProcess	DNA-templated transcription initiation	PAXIP1 CAND1 ATAD2 MED29 ZNF451	1.95e-04	231	48	5	GO:0006352
GeneOntologyBiologicalProcess	negative regulation of DNA-templated DNA replication	LIG3 TIMELESS	2.88e-04	11	48	2	GO:2000104
GeneOntologyBiologicalProcess	Rac protein signal transduction	KBTBD6 KBTBD7 FARP1	3.69e-04	60	48	3	GO:0016601
GeneOntologyBiologicalProcess	regulation of DNA recombination	PAXIP1 RNF8 LIG3 TIMELESS	4.08e-04	150	48	4	GO:0000018
Domain	BRCT	PAXIP1 LIG3	1.39e-03	22	47	2	SM00292
Domain	-	PAXIP1 LIG3	1.52e-03	23	47	2	3.40.50.10190
Domain	BRCT	PAXIP1 LIG3	1.94e-03	26	47	2	PS50172
Domain	Longin-like_dom	AP1S3 VAMP7	2.25e-03	28	47	2	IPR011012
Domain	BRCT_dom	PAXIP1 LIG3	2.25e-03	28	47	2	IPR001357
Domain	P-loop_NTPase	SHPRH CMPK1 TRANK1 KIF27 ATAD2 UST HYDIN	5.00e-03	848	47	7	IPR027417
Domain	-	RNF8 SHPRH RC3H2 ZMIZ1 RNF148	5.25e-03	449	47	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF8 SHPRH RC3H2 ZMIZ1 RNF148	5.76e-03	459	47	5	IPR013083
Domain	ZF_RING_1	RNF8 SHPRH RC3H2 RNF148	6.08e-03	291	47	4	PS00518
Domain	-	KBTBD6 KBTBD7	6.49e-03	48	47	2	2.120.10.80
Domain	ZF_RING_2	RNF8 SHPRH RC3H2 RNF148	6.61e-03	298	47	4	PS50089
Domain	RING	RNF8 SHPRH RC3H2 RNF148	7.16e-03	305	47	4	SM00184
Domain	Znf_RING_CS	RNF8 SHPRH RC3H2	7.99e-03	163	47	3	IPR017907
Domain	Kelch-typ_b-propeller	KBTBD6 KBTBD7	8.46e-03	55	47	2	IPR015915
Domain	Znf_RING	RNF8 SHPRH RC3H2 RNF148	9.01e-03	326	47	4	IPR001841
Domain	Kelch	KBTBD6 KBTBD7	9.37e-03	58	47	2	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KBTBD6 KBTBD7	9.68e-03	59	47	2	IPR011043
Domain	BACK	KBTBD6 KBTBD7	1.00e-02	60	47	2	SM00875
Pubmed	The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.	KBTBD6 KBTBD7	5.59e-06	3	48	2	32572597
Pubmed	Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.	PAXIP1 RNF8	1.12e-05	4	48	2	19124460
Pubmed	PTIP regulates 53BP1 and SMC1 at the DNA damage sites.	PAXIP1 RNF8	1.12e-05	4	48	2	19414588
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	RNF8 PDS5A LDB3 HECTD4	1.23e-05	102	48	4	9734811
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PAXIP1 SHPRH HAUS7 LIG3 KBTBD6 ATAD2 MED29	2.78e-05	645	48	7	25281560
Pubmed	Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation.	KBTBD6 KBTBD7	3.90e-05	7	48	2	33990333
Pubmed	Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily.	PAXIP1 SHPRH LIG3	4.08e-05	48	48	3	22242598
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	LIG3 PDS5A RC3H2 CAND1 HYDIN TASOR2	4.42e-05	469	48	6	27634302
Pubmed	Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity.	CAND1 KBTBD6 KBTBD7	6.85e-05	57	48	3	34878901
Pubmed	Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.	ZMIZ1 PREP	8.33e-05	10	48	2	19795399
Pubmed	CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.	KBTBD6 KBTBD7	1.02e-04	11	48	2	25684205
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PDS5A TIMELESS VPS52 IDH3B KBTBD6 GLS	1.17e-04	560	48	6	35241646
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SHPRH LIG3 PDS5A TIMELESS ATAD2 ZNF451	1.83e-04	608	48	6	36089195
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	PAXIP1 LIG3 IDH3B RASA2 PRICKLE1 GLS	2.37e-04	638	48	6	31182584
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	CAND1 KBTBD6 KBTBD7	2.41e-04	87	48	3	37495603
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	PAXIP1 PDS5A KBTBD7 ZNF451	2.52e-04	222	48	4	37071664
Pubmed	CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.	VIPR2 TIMELESS	2.81e-04	18	48	2	20180986
Pubmed	NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.	VIPR2 TIMELESS	2.81e-04	18	48	2	19470168
Pubmed	Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.	VIPR2 TIMELESS	3.14e-04	19	48	2	20072116
Pubmed	Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.	VIPR2 TIMELESS	3.14e-04	19	48	2	20554694
Pubmed	Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.	TUBB1 CAND1 GLS	3.32e-04	97	48	3	22360420
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	RC3H2 VPS52 ATAD2 FARP1	4.02e-04	251	48	4	29778605
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	CAND1 KBTBD7	4.23e-04	22	48	2	35120648
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	LIG3 PDS5A CMPK1 MFAP4 CAND1 MED29 ZNF451	4.55e-04	1014	48	7	32416067
Pubmed	Dimerization quality control ensures neuronal development and survival.	KBTBD6 KBTBD7	5.05e-04	24	48	2	30190310
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	GRM1 GLS TPH2	5.89e-04	118	48	3	19156168
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	LIG3 PDS5A CAND1 IDH3B KIF27 GRM1 ATAD2 GLS	6.82e-04	1425	48	8	30948266
Pubmed	DNA cloning using in vitro site-specific recombination.	HAUS7 LDB3 GRM1 KBTBD7 FARP1 VAMP7	7.54e-04	794	48	6	11076863
Pubmed	Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.	MTMR1 IDH3B HECTD4	1.11e-03	147	48	3	16959763
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	MFAP4 LDB3 CAND1 GLS	1.13e-03	331	48	4	29199018
Cytoband	13q14.11	KBTBD6 KBTBD7	7.74e-04	39	48	2	13q14.11
Cytoband	Xq28	HAUS7 MTMR1 VAMP7	8.44e-04	176	48	3	Xq28
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	HAUS7 MTMR1 VAMP7	1.46e-03	213	48	3	chrXq28
Cytoband	1p36.13	PADI6 MST1L	1.59e-03	56	48	2	1p36.13
Cytoband	Ensembl 112 genes in cytogenetic band chr6q24	SHPRH GRM1	3.06e-03	78	48	2	chr6q24
GeneFamily	Olfactory receptors, family 9	OR9G1 OR9G9	8.47e-04	23	34	2	156
GeneFamily	Ring finger proteins	RNF8 SHPRH RC3H2 RNF148	1.70e-03	275	34	4	58
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GRM1 FARP1 HYDIN	4.70e-03	181	34	3	694
GeneFamily	LIM domain containing	LDB3 PRICKLE1	5.49e-03	59	34	2	1218
Disease	hydrocephalus (implicated_via_orthology)	TMEM67 KIF27 HYDIN	3.60e-06	19	47	3	DOID:10908 (implicated_via_orthology)
Disease	electrocardiography	LIG3 LDB3 TRANK1 ZMIZ1 UST PREP	1.88e-04	530	47	6	EFO_0004327
Disease	Minimal Brain Dysfunction	GRM1 TPH2	5.62e-04	22	47	2	C1321905
Disease	Attention Deficit Disorder	GRM1 TPH2	5.62e-04	22	47	2	C0041671
Disease	Attention deficit hyperactivity disorder	GRM1 TPH2	6.70e-04	24	47	2	C1263846
Disease	pseudotumor cerebri	OR9G1 OR9G9	7.88e-04	26	47	2	EFO_1001132

Protein segments in the cluster

Peptide	Gene	Start	Entry
DTFLEELAENCVGYC	ATAD2	621	Q6PL18
FLCNCEQQRFKEDVY	MTMR1	541	Q13613
FLSCPICYNEFDENV	RC3H2	11	Q9HBD1
NFCRENIIDDFFCDL	OR9G1	166	Q8NH87
YNICFELEDCNEIFI	PDS5A	151	Q29RF7
DCFCTINLDQEEVYR	RASA2	61	Q15283
LDFYFQLCSIEVTCE	GLS	411	O94925
YFCCAIENQDNELLT	AP1S3	66	Q96PC3
EECFRCQKFIDEQNY	PAXIP1	931	Q6ZW49
INDFDCYLTEVGDIC	PADI6	661	Q6TGC4
DVCFVEEQNNVYCER	LDB3	586	O75112
FDYCALRRCDQVQFE	MST1L	456	Q2TV78
VKFCNVDDDELREYC	CAND1	261	Q86VP6
YQCCVEEAFTFLVDL	KIF27	411	Q86VH2
ILNVCDDYDVTCNEF	KCNG1	101	Q9UIX4
RFDKCLEEFYALCDQ	MED29	101	Q9NX70
QEACVFNDEIYCICD	KBTBD7	516	Q8WVZ9
NFCCENIIDDFFCDL	OR9G9	166	P0C7N8
QDANVCLFVFDCIYF	LIG3	586	P49916
CLFVFDCIYFNDVSL	LIG3	591	P49916
LLEDSLFCEEFIQQC	HECTD4	1871	Q9Y4D8
CFDDFQCAAEYLIKE	PREP	526	P48147
FVCFTCNELLVDLIY	PRICKLE1	156	Q96MT3
DGLFLQCCEEVAELY	IDH3B	226	O43837
YEVELNECVQCEFNF	HYDIN	4216	Q4G0P3
LENFCRDFELQKVCY	FARP1	661	Q9Y4F1
AFLQVYDDELGECCQ	HAUS7	271	Q99871
LQFDDYFLNVCFEVI	ERAP2	411	Q6P179
FVLFFDCNNEICIER	CMPK1	116	P30085
ICTACKENEYVQDEF	GRM1	546	Q13255
QEACVFNEEIYCICD	KBTBD6	516	Q86V97
IFDLLFFCVVDLACQ	TMEM67	941	Q5HYA8
VLENELQCIICSEYF	RNF8	396	O76064
ERFCLQQPLDCDDIY	MFAP4	31	P55083
DYRFECICGELDQID	SHPRH	656	Q149N8
ADACFCIDNEALYDI	TUBB1	196	Q9H4B7
YLDINECILENYPEC	UST	226	Q9Y2C2
DNSCREYLFICEFFV	VPS52	391	Q8N1B4
FLRDFCSEFLENCYN	TIMELESS	341	Q9UNS1
KYFCGLCDLIFNVEE	ZNF451	666	Q9Y4E5
LDLNEDNCVVCFDTY	RNF148	251	Q8N7C7
NCFHYEDVAVLCDEF	SSC4D	146	Q8WTU2
DAIAACFLINCLYEQ	SPINT1	111	O43278
CQDRIVYLCITDDDF	VAMP7	56	P51809
CLQECLITTFQEAYF	TPH2	406	Q8IWU9
VAVLYCFLNSEVQCE	VIPR2	371	P41587
QNYLEEKVCFQDLCF	TASOR2	76	Q5VWN6
EKVCFQDLCFNLYEV	TASOR2	81	Q5VWN6
CFIRLLENCIDQFYV	TRANK1	2361	O15050
VQCFDLESYLQLNCE	ZMIZ1	761	Q9ULJ6