Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionrecombination hotspot binding

PRDM9 PRDM7

1.02e-0422022GO:0010844
GeneOntologyMolecularFunctionalpha-L-arabinofuranosidase activity

OTOGL OTOG

1.02e-0422022GO:0046556
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

PRDM9 PRDM7 SETD5

2.71e-04132023GO:0046975
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

ABO CHPF B4GALNT4 GALNT9

4.16e-04352024GO:0008376
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

RAPGEF3 BCAR3 HERC2 PREX1 DOCK2 ARFGEF1 TIAM1 ARHGEF1 FGD6

5.94e-042312029GO:0005085
GeneOntologyMolecularFunctionnucleoside:sodium symporter activity

SLC28A3 SLC28A1

6.03e-0442022GO:0005415
GeneOntologyMolecularFunctionnucleobase:monoatomic cation symporter activity

SLC28A3 SLC28A1

6.03e-0442022GO:0015391
GeneOntologyMolecularFunctionpyrimidine- and adenosine-specific:sodium symporter activity

SLC28A3 SLC28A1

6.03e-0442022GO:0015389
DomainARM-type_fold

GPRASP1 DOHH ARMH1 EFR3A URB1 RRP12 USP35 HEATR5B DOCK2 RELCH ARFGEF1 BTAF1 SDAD1 HEATR6 MROH1 FHOD1

7.05e-0733919816IPR016024
DomainARM-like

GPRASP1 DOHH ARMH1 EFR3A RRP12 USP35 HEATR5B DOCK2 RELCH ARFGEF1 BTAF1 HEATR6 MROH1 FHOD1

1.19e-0627019814IPR011989
Domain-

GPRASP1 DOHH ARMH1 EFR3A RRP12 HEATR5B RELCH ARFGEF1 BTAF1 HEATR6 MROH1 FHOD1

4.58e-06222198121.25.10.10
DomainHEAT_REPEAT

DOHH HEATR5B RELCH BTAF1 HEATR6 MROH1

9.82e-05701986PS50077
DomainPAS

NPAS3 KCNH1 KCNH2 NCOA2

1.30e-04251984PF00989
DomainPAS_fold

NPAS3 KCNH1 KCNH2 NCOA2

1.30e-04251984IPR013767
DomainPAC

NPAS3 KCNH1 KCNH2 NCOA2

1.53e-04261984IPR001610
DomainPAC

NPAS3 KCNH1 KCNH2 NCOA2

1.53e-04261984SM00086
DomainC_nuclsd_transpt

SLC28A3 SLC28A1

3.33e-0431982IPR008276
DomainCNT_C_dom

SLC28A3 SLC28A1

3.33e-0431982IPR011657
DomainC_nuclsd_transpt_met_bac

SLC28A3 SLC28A1

3.33e-0431982IPR018270
DomainGate_dom

SLC28A3 SLC28A1

3.33e-0431982IPR011642
DomainNucleos_tra2_N

SLC28A3 SLC28A1

3.33e-0431982PF01773
DomainNucleos_tra2_C

SLC28A3 SLC28A1

3.33e-0431982PF07662
DomainGate

SLC28A3 SLC28A1

3.33e-0431982PF07670
DomainCNT_N_dom

SLC28A3 SLC28A1

3.33e-0431982IPR002668
DomainCNMP_BINDING_1

PNPLA6 RAPGEF3 KCNH1 KCNH2

3.49e-04321984PS00888
DomainCNMP_BINDING_2

PNPLA6 RAPGEF3 KCNH1 KCNH2

3.49e-04321984PS00889
DomainPAS

NPAS3 KCNH1 KCNH2 NCOA2

3.49e-04321984SM00091
DomaincNMP

PNPLA6 RAPGEF3 KCNH1 KCNH2

4.43e-04341984SM00100
DomainPAS

NPAS3 KCNH1 KCNH2 NCOA2

4.43e-04341984PS50112
DomainPAS

NPAS3 KCNH1 KCNH2 NCOA2

4.43e-04341984IPR000014
DomaincNMP_binding

PNPLA6 RAPGEF3 KCNH1 KCNH2

4.43e-04341984PF00027
DomaincNMP-bd_dom

PNPLA6 RAPGEF3 KCNH1 KCNH2

4.96e-04351984IPR000595
DomainCNMP_BINDING_3

PNPLA6 RAPGEF3 KCNH1 KCNH2

4.96e-04351984PS50042
DomaincNMP-bd-like

PNPLA6 RAPGEF3 KCNH1 KCNH2

6.82e-04381984IPR018490
DomainHEAT_type_2

DOHH RELCH MROH1

7.15e-04171983IPR021133
DomainZF_ZZ_2

ZZEF1 HERC2 DTNB

8.51e-04181983PS50135
DomainZF_ZZ_1

ZZEF1 HERC2 DTNB

8.51e-04181983PS01357
DomainZZ

ZZEF1 HERC2 DTNB

8.51e-04181983PF00569
DomainCH

SPTBN1 CFAP47 FLNA MACF1 LIMCH1

8.82e-04701985PF00307
Domain-

SPTBN1 CFAP47 FLNA MACF1 LIMCH1

9.40e-047119851.10.418.10
DomainZnf_ZZ

ZZEF1 HERC2 DTNB

1.00e-03191983IPR000433
DomainZnF_ZZ

ZZEF1 HERC2 DTNB

1.00e-03191983SM00291
DomainCH

SPTBN1 CFAP47 FLNA MACF1 LIMCH1

1.07e-03731985PS50021
DomainCH-domain

SPTBN1 CFAP47 FLNA MACF1 LIMCH1

1.20e-03751985IPR001715
DomainSET

KMT2B PRDM9 PRDM7 SETD5

1.41e-03461984SM00317
DomainCT

VWF SLIT3 OTOG

1.56e-03221983SM00041
DomainAlpha_kinase

TRPM7 ALPK1

1.63e-0361982PF02816
DomainMHCK_EF2_kinase

TRPM7 ALPK1

1.63e-0361982IPR004166
DomainALPHA_KINASE

TRPM7 ALPK1

1.63e-0361982PS51158
DomainAlpha_kinase

TRPM7 ALPK1

1.63e-0361982SM00811
Domain-

PNPLA6 RAPGEF3 KCNH1 KCNH2

1.66e-034819842.60.120.10
Domain-

ABO EXT1 B4GALT1 B4GALNT4 GALNT9

1.70e-038119853.90.550.10
DomainACTININ_2

SPTBN1 FLNA MACF1

1.78e-03231983PS00020
DomainACTININ_1

SPTBN1 FLNA MACF1

1.78e-03231983PS00019
DomainActinin_actin-bd_CS

SPTBN1 FLNA MACF1

1.78e-03231983IPR001589
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PALD1 RNF223 KMT2B SRCAP ZZEF1 PLXNB2 URB1 SARS2 PNPLA6 KCNH2 RRP12 PLA2G6 HERC2 CHPF PREX1 BAHCC1 AGAP3 FLNA B4GALNT4 RHBDF1 CHCHD5 AGPAT2 BTAF1 FAAP100 KANSL3 NHSL1 MROH1 ADAMTS7 SETD5 ZFYVE26

3.51e-1211052053035748872
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

HK3 INPP5B SPTBN1 SRCAP URB1 KCNH1 EXOC3L4 CPLANE1 NCOA2 KIF13B FLNA RHBDF1 MAP4K3 FRMPD1 OAS1 PATL1 TBCCD1 SETD5 ARHGEF1 MACF1 LPAR2 ZMAT1

5.28e-0710842052211544199
Pubmed

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.

PREX1 DOCK2 TIAM1

8.04e-074205337383235
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

GIPC1 KMT2B MRPL12 WDR43 EFR3A CLPTM1L URB1 PNPLA6 DHCR24 RRP12 CNOT7 PPIE HERC2 HEATR5B PREX1 AGAP3 RHBDF1 AGPAT2 SDAD1 MED15 GZF1 CTCF SETD5 MACF1 LIMCH1 KDM1A

8.90e-0714972052631527615
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

PALD1 CTTNBP2 ETV1 PLXNB2 BOK RAPGEF3 USP35 BCAR3 HERC2 NCOA2 MRPL50 B4GALNT4 RHOBTB3 AGPAT2 AMDHD2 FAAP100 TRMU MROH1 ARSL SAMD11 FHOD1

1.16e-0512152052115146197
Pubmed

Functional proteomics mapping of a human signaling pathway.

HIVEP1 KMT2B SPTBN1 ZZEF1 PHKA2 SPARCL1 HERC2 CHPF FLNA FLT4 VWF FAF1 LIMS2 MACF1

1.25e-055912051415231748
Pubmed

Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods.

KCNH1 KCNH2

3.46e-052205219671703
Pubmed

Co-inherited mutations of Fas and caspase-10 in development of the autoimmune lymphoproliferative syndrome.

CASP10 FAF1

3.46e-052205217999750
Pubmed

[Expression and prognosis effect of methylation-regulated SLIT3 and SPARCL1 genes in smoking-related lung adenocarcinoma].

SPARCL1 SLIT3

3.46e-052205231154721
Pubmed

hERG channel blockade by externally applied quaternary ammonium derivatives.

KCNH1 KCNH2

3.46e-052205221320466
Pubmed

Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics.

KCNH1 KCNH2

3.46e-052205220126398
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

3.46e-052205226807827
Pubmed

Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression.

DHCR24 NR1H3

3.46e-052205223359226
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3B CNTNAP3

3.46e-052205231150793
Pubmed

Neuronal phospholipid deacylation is essential for axonal and synaptic integrity.

PNPLA6 PLA2G6

3.46e-052205222903185
Pubmed

Grb7 and Filamin-a associate and are colocalized to cell membrane ruffles upon EGF stimulation.

FLNA GRB7

3.46e-052205224089360
Pubmed

A family of potassium channel genes related to eag in Drosophila and mammals.

KCNH1 KCNH2

3.46e-05220528159766
Pubmed

Effect of von Willebrand factor Y/C1584 on in vivo protein level and function and interaction with ABO blood group.

ABO VWF

3.46e-052205217119126
Pubmed

Distribution of von Willebrand factor levels in young women with and without bleeding symptoms: influence of ABO blood group and promoter haplotypes.

ABO VWF

3.46e-052205218521502
Pubmed

Similar phenotypes caused by mutations in OTOG and OTOGL.

OTOGL OTOG

3.46e-052205224378291
Pubmed

Congenital long QT syndrome: a case report of LQT2 and LQT13 in a neonate.

KCNH2 KCNJ5

3.46e-052205225417227
Pubmed

A human MAP kinase interactome.

HIVEP1 SPTBN1 CCDC97 HERC2 CPLANE1 FLNA VWF MAP4K3 SIK3 ARHGEF1 FHOD1 MACF1

3.53e-054862051220936779
Pubmed

Human transcription factor protein interaction networks.

HIVEP1 KMT2B MRPL12 SPTBN1 PSMD13 SRCAP STAT2 RRP12 CNOT7 HERC2 NCOA2 MRPL50 IRF8 PATL1 SDAD1 MED15 KANSL3 AGO1 CTCF SAMD11 KDM1A RBM34

4.12e-0514292052235140242
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

HIVEP1 TRPM7 SPTBN1 TAB1 AGAP3 KIF13B ALPK1 SIK3 NHSL1 TIAM1 SAMD11 ARHGEF1 MACF1 LIMCH1 FGD6 OTOG

5.74e-058612051636931259
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

HIVEP1 SPATA31D4 SPATA31D3 NCOA2 DNAH2 PRDM7 AGO1 MAPK8IP2

7.82e-05233205837704626
Pubmed

The response of the QT interval to the brief tachycardia provoked by standing: a bedside test for diagnosing long QT syndrome.

KCNH1 KCNH2

1.03e-043205220116193
Pubmed

Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3.

SLC28A3 SLC28A1

1.03e-043205217453413
Pubmed

Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit.

MED15 SERPIND1

1.03e-043205211414760
Pubmed

The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism.

ABO VWF

1.03e-043205215735796
Pubmed

Evaluating Serum Levels of Pentraxin-3, von Willebrand Factor and C-X-C Motif Chemokine Ligand 13 as Inflammatory Markers of Unstable Angina Pectoris.

PTX3 VWF

1.03e-043205231066256
Pubmed

Experimental validation of 5 in-silico predicted glioma biomarkers.

PLXNB2 SLIT3

1.03e-043205224158112
Pubmed

Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters.

SLC28A3 SLC28A1

1.03e-043205233910126
Pubmed

The PNPLA-family phospholipases involved in glycerophospholipid homeostasis of HeLa cells.

PNPLA6 PLA2G6

1.03e-043205227317427
Pubmed

Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions.

NCOA2 FLNA

1.03e-043205212682292
Pubmed

Comprehensive Analysis of Gene Expression Profiles and DNA Methylome reveals Oas1, Ppie, Polr2g as Pathogenic Target Genes of Gestational Diabetes Mellitus.

PPIE OAS1

1.03e-043205230389953
Pubmed

Phenotypic and genetic analysis of children with unexplained neurodevelopmental delay and neurodevelopmental comorbidities in a Chinese cohort using trio-based whole-exome sequencing.

KCNH1 PLA2G6

1.03e-043205238764027
Pubmed

Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.

ETV1 TIAM1

1.03e-043205222586091
Pubmed

Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.

PREX1 TIAM1

1.03e-043205234624316
Pubmed

Alpha 2A adrenergic receptor polymorphism is associated with plasma von Willebrand factor levels in a general population.

ABO VWF

1.03e-043205218600088
Pubmed

SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1.

SRCAP NCOA2

1.03e-043205214500758
Pubmed

Thyroid hormone receptor and liver X receptor competitively up-regulate human selective Alzheimer's disease indicator-1 gene expression at the transcriptional levels.

DHCR24 NR1H3

1.03e-043205223416078
Pubmed

Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance.

SLC28A3 SLC28A1

1.03e-043205228385889
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

PALD1 MRPL12 PSMD13 NEK5 CNOT7 SPAG16 CHPF SNX9 AGAP3 KIF13B RELCH AGPAT2 FAAP100 URGCP MED15 TIAM1 SETD5 FGD6 KDM1A CDK4

1.17e-0413212052027173435
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

DUSP28 NUP210L PSMD13 NFU1 PHKA2 PMPCA DHCR24 TAB1 SNX9 NCOA2 MRPL50 DTNB CRKL LRR1 RBM34 CDK4

1.41e-049312051627432908
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

PLXNB2 URB1 PNPLA6 DHCR24 RRP12 HEATR5B CHPF SNX9 FLNA DNAH2 ARFGEF1 BTAF1 URGCP FAF1 ARHGEF1 CDK4

1.61e-049422051631073040
Pubmed

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

BCAR3 GRB7 SH2D5 CRKL MAPK8IP2

1.98e-0490205516273093
Pubmed

Zika virus spreads through infection of lymph node-resident macrophages.

STAT2 SIGLEC1

2.06e-044205236795561
Pubmed

Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.

STAT2 OAS1

2.06e-044205222305621
Pubmed

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade.

TIAM1 MAPK8IP2

2.06e-044205212024021
Pubmed

DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.

DOCK2 CRKL

2.06e-044205212393632
Pubmed

Regulation of hERG and hEAG channels by Src and by SHP-1 tyrosine phosphatase via an ITIM region in the cyclic nucleotide binding domain.

KCNH1 KCNH2

2.06e-044205224587194
Pubmed

Role of the transporter regulator protein (RS1) in the modulation of concentrative nucleoside transporters (CNTs) in epithelia.

SLC28A3 SLC28A1

2.06e-044205222492015
Pubmed

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

MYH6 FLT4

2.06e-044205228991257
Pubmed

Inhibition of monocytic differentiation by phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBPepsilon.

STAT2 IRF8

2.06e-044205216918696
Pubmed

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.

PREX1 TIAM1

2.06e-044205226887924
Pubmed

Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation.

RHBDF1 KDM1A

2.06e-044205224078251
Pubmed

Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.

PRDM9 PRDM7

2.06e-044205218231586
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

CLPTM1L RRP12 HERC2 FLNA BTAF1 HEATR6 TIAM1

2.08e-04202205733005030
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

GIPC1 GPRASP1 TRPM7 SPTBN1 SARS2 SPARCL1 HERC2 CHPF PREX1 AGAP3 NCOA2 VWF RHOBTB3 FAF1 HEATR6 TIAM1 MACF1 USPL1 MAPK8IP2

2.35e-0412852051935914814
Pubmed

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

PALD1 HIVEP1 STAT2 CLPTM1L TAB1 IRF8 KDM1A CDK4

2.95e-04283205821903422
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

USP35 HEATR5B PREX1 KANSL3 NHSL1 FGD6

3.07e-04153205610718198
Pubmed

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

ZNF688 PHKA2 BAHCC1 CASP10 MON1B ZNF792 SETD5

3.21e-04217205734048709
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZZEF1 WDR43 EFR3A DHCR24 RELCH RHOBTB3 SIK3 URGCP KANSL3 SLIT3 KDM1A

3.30e-045292051114621295
Pubmed

XIAP Interacts with and Regulates the Activity of FAF1.

TAB1 FAF1

3.42e-045205228414080
Pubmed

Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.

KCNH2 KCNJ5

3.42e-045205228464250
Pubmed

Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients.

SLC28A3 SLC28A1

3.42e-045205217926640
Pubmed

Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.

MYH6 CDK4

3.42e-045205224858909
Pubmed

TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.

SPTBN1 CTCF

3.42e-045205226784546
Pubmed

The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.

GIPC1 LPAR2

3.42e-045205223145131
Pubmed

LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.

IRF8 NR1H3

3.42e-045205221757649
Pubmed

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

TRPM7 GFRA3 KCNH2 NCOA2

3.63e-0457205424952745
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

TAB1 FLNA MAP4K3 SH2D5 FGD6

3.71e-04103205521706016
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

BAHCC1 RELCH DNAH2 ALPK1 URGCP

3.71e-04103205510819331
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

GIPC1 INPP5B PSMD13 PPIE TAB1 SNX9 PREX1 AGAP3 DOCK2 FASTKD1 CRKL TIAM1 ARHGEF1 FGD6 KDM1A

3.80e-049162051532203420
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

KMT2B SRCAP PLXNB2 HERC2 ZFYVE26

3.88e-0410420559205841
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

PNPLA6 ARFGEF1 BTAF1 HEATR6 FHOD1

3.88e-04104205531240132
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

GIPC1 KMT2B PLXNB2 BOK KCNH1 KCNH2 MAP4K3 DNAH2 SIK3 CRKL SETD5 KDM1A CDK4

4.29e-047302051334857952
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

CTTNBP2 SPTBN1 PLXNB2 DHCR24 PLA2G6 KIF13B RHOBTB3 UBA2 GRB7 OAS1 ALPK1 SIK3 SH2D5 APIP AGO1 CTCF SETD5 ARHGEF1

4.35e-0412422051830973865
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

FASTKD1 MROH1 WDR97 ZMAT1 MEGF10

4.43e-04107205511347906
Pubmed

XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.

TAB1 CDK4

5.11e-046205235437868
Pubmed

In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development.

CNTNAP3B CNTNAP3

5.11e-046205234143959
Pubmed

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.

ABO VWF

5.11e-046205220231535
Pubmed

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.

FCGR1BP NR1H3

5.11e-046205230076102
Pubmed

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

FCGR1BP IRF8

5.11e-046205231061494
Pubmed

Alpha-kinases: a new class of protein kinases with a novel catalytic domain.

TRPM7 ALPK1

5.11e-046205210021370
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TRPM7 MRPL12 SPTBN1 PSMD13 PLXNB2 EFR3A CLPTM1L URB1 SARS2 PNPLA6 PMPCA RRP12 PPIE CCDC97 HERC2 MRPL50 SIK3 TIAM1 MACF1 RBM34

5.40e-0414872052033957083
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

KCNH1 DOCK2 KIF13B VWF IRF8 PTPRT

5.53e-04171205620201926
Pubmed

The yin-yang of PR-domain family genes in tumorigenesis.

PRDM9 PRDM7

7.12e-047205210668202
Pubmed

Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.

DOCK2 SLC28A1

7.12e-047205228100790
Pubmed

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.

ABO ADAMTS7

7.12e-047205221239051
Pubmed

Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.

CNOT7 CDK4

7.12e-047205210602502
Pubmed

Role of Rck-Pat1b binding in assembly of processing-bodies.

PATL1 AGO1

7.12e-047205223535175
Pubmed

Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation.

VWF IRF8

7.12e-047205223863621
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

HIVEP1 KMT2B SPTBN1 PNPLA6 RRP12 FLNA UBA2 BTAF1 PATL1 URGCP KANSL3 FHOD1 LIMCH1

7.37e-047742051315302935
Pubmed

Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

INPP5B ZNF688 CNOT7 PLA2G6 NLRP5 CFAP47 OAS1 HEATR6

7.48e-04326205817015433
Pubmed

Phospho-tyrosine dependent protein-protein interaction network.

KMT2B STAT2 C4orf17 BCAR3 GRB7 DOK2 CRKL ZMAT1 MAPK8IP2

7.83e-04410205925814554
Pubmed

Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report.

FLT4 VWF

9.46e-048205219910638
Pubmed

Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling.

FLT4 VWF

9.46e-048205217438136
Pubmed

Genetic analysis of Down syndrome-associated heart defects in mice.

URB1 TIAM1

9.46e-048205221442329
Pubmed

Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu.

ETV1 NCOA2

9.46e-048205214747462
InteractionTOP3B interactions

PALD1 RNF223 KMT2B SRCAP ZZEF1 PLXNB2 URB1 SARS2 PNPLA6 KCNH2 RRP12 CNOT7 PLA2G6 HERC2 CHPF PREX1 BAHCC1 AGAP3 FLNA B4GALNT4 RHBDF1 CHCHD5 AGPAT2 BTAF1 PATL1 FAAP100 CRKL KANSL3 NHSL1 MROH1 ADAMTS7 SETD5 ZFYVE26

4.77e-06147019533int:TOP3B
GeneFamilyBeta 4-glycosyltransferases

B4GALT1 CHPF B4GALNT4

2.29e-04171303425
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

ZZEF1 HERC2 DTNB

2.74e-0418130391
GeneFamilyPDZ domain containing

GIPC1 PREX1 CARD14 FRMPD1 TAMALIN TIAM1

8.10e-0415213061220
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PREX1 TIAM1 ARHGEF1 FGD6

1.30e-03661304722
GeneFamilyOlfactory receptors, family 2

OR2L8 OR2L3 OR2L5 OR2B6 OR2L2

1.34e-031131305149
GeneFamilyPatatin like phospholipase domain containing

PNPLA6 PLA2G6

2.22e-03101302466
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B SPTBN1 SPARCL1 PREX1 FLT4 VWF LIMS2 ADAMTS7 LIMCH1

1.14e-08179205108f9e538c822940785130297712b75131812a4603
ToppCelldroplet-Bladder-nan-24m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTTNBP2 FAP SPARCL1 FLT4 VWF DNAH2 XRCC3 LIMS2 LIMCH1

2.04e-07185205990caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B SPTBN1 SPARCL1 PREX1 FLT4 VWF LIMS2 LIMCH1

3.32e-07196205922767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B SPTBN1 SPARCL1 PREX1 FLT4 VWF LIMS2 LIMCH1

3.32e-071962059adee900dcd16dbaba15c58bdcace09ba20214950
ToppCellNeuronal-Excitatory-eC(RORB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

CCDC168 FAP OTOGL KCNH1 SPARCL1 BCAR3 GRB7 PTPRT MEGF10

3.94e-0720020598c803a0ce25e140b46036f6aabefc5502601f408
ToppCell356C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PALD1 CNTNAP3B CCDC168 SRCAP FCGR1BP DOCK2 B4GALNT4 VWF

7.62e-0715920580a3a363b30a8c741e1a3e2525725108d03c21776
ToppCell356C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PALD1 CNTNAP3B CCDC168 SRCAP FCGR1BP DOCK2 B4GALNT4 VWF

7.62e-071592058299e2162a82e31196d7f3a110c2db622349edfff
ToppCellNS-critical-LOC-Myeloid-Basophil|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

OR2L8 CTTNBP2 ARMH1 GFRA3 RAPGEF3 KCNH2 FLT4 ADAMTS7

7.99e-0716020588a4746463ca1976f7d6de803496c851249ced797
ToppCellmoderate-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CTTNBP2 ARMH1 GFRA3 KCNH2 CMA1 RHOBTB3 ADAMTS7 ZNF792

1.05e-061662058c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

HK3 PHKA2 PEMT FCGR1BP XRCC3 SLIT3 SIGLEC1

2.42e-06130205792913960e4367261ba08a405b61a421bc5e18169
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B SPTBN1 SPARCL1 PREX1 FLT4 LIMS2 LIMCH1

3.38e-06194205874a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCellChildren_(3_yrs)-Endothelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

PALD1 CNTNAP3B SPTBN1 SPARCL1 FLT4 VWF TAMALIN LIMS2

3.51e-061952058094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPARCL1 PREX1 FLT4 VWF TAMALIN LIMS2 LIMCH1

3.64e-061962058ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCellBronchial-NucSeq-Immune_Myeloid-Dendritic_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PALD1 OR2B6 KIF25-AS1 PREX1 DOCK2 IRF8 TIAM1 SIGLEC1

3.78e-061972058e0fc098bfb5a8b7824ae339f3adda30f78360d0b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 SPARCL1 PREX1 FLT4 VWF TAMALIN LIMS2

3.78e-0619720580f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2 LIMCH1

3.93e-061982058fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2 LIMCH1

3.93e-0619820580a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2 LIMCH1

3.93e-06198205807701c73137947ed4a27e225975329235bbb8734
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2 NHSL1

3.93e-0619820581378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCellLung_Parenchyma-Control-Endothelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CNTNAP3B SPTBN1 RAPGEF3 SPARCL1 FLT4 VWF TAMALIN LIMS2

4.23e-06200205841ac6adbf61763aa8a81a0ed586c4a5542a42cc5
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CNTNAP3B SPTBN1 RAPGEF3 SPARCL1 FLT4 VWF TAMALIN LIMS2

4.23e-0620020585109b417c066ecca0252008206b4f4b7a14c8702
ToppCellParenchyma_Control_(B.)-Endothelial-TX|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CNTNAP3B SPTBN1 RAPGEF3 SPARCL1 FLT4 VWF TAMALIN LIMS2

4.23e-0620020589e5627e11288713aa9b622aae40e849dd6eacd29
ToppCellNS-critical-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

OR2L8 CTTNBP2 GFRA3 KCNH2 FLT4 ADAMTS7 ZNF792

9.52e-061602057c61869d9dbba250270e59366e15af204e5b4395d
ToppCellHippocampus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)|Hippocampus / BrainAtlas - Mouse McCarroll V32

HK3 FCGR1BP DOCK2 DOK2 ASGR2 SIGLEC1

1.40e-051132056d5f183263cec9922d23cfd38ce9157eef4e58edb
ToppCellHippocampus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

HK3 FCGR1BP DOCK2 DOK2 ASGR2 SIGLEC1

1.40e-051132056177414e4c859b047a4644664c596a3c22199cdf2
ToppCellHippocampus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--|Hippocampus / BrainAtlas - Mouse McCarroll V32

HK3 FCGR1BP DOCK2 DOK2 ASGR2 SIGLEC1

1.40e-0511320561df80af2c690dac6bfd3dfd7d0052b66c1ae6ea5
ToppCellHippocampus-Hematopoietic-MACROPHAGE-MP1(C1qb)|Hippocampus / BrainAtlas - Mouse McCarroll V32

HK3 FCGR1BP DOCK2 DOK2 ASGR2 SIGLEC1

1.40e-0511320564b5f545dc02364c5d96a02b0acd68faf1ec4192b
ToppCellHippocampus-Hematopoietic-MACROPHAGE|Hippocampus / BrainAtlas - Mouse McCarroll V32

HK3 FCGR1BP DOCK2 DOK2 ASGR2 SIGLEC1

1.40e-051132056927d1071f0719b778f0c3d358c5f96a6ffac6645
ToppCellmoderate-Myeloid-Mast_cell|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CTTNBP2 ARMH1 GFRA3 KCNH2 CMA1 ADAMTS7 ZNF792

1.70e-051752057bbd2971bc6d69e507f90a637834d0936c205c590
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ETV1 PLXNB2 FAP FCGR1BP EXOC3L4 NR1H3 SIGLEC1

1.83e-05177205726bad614560609d318bfc9c235a698bca4e1c22c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B RAPGEF3 BCAR3 SPAG16 DTNB SAMD11 LIMCH1

2.04e-051802057023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Mast_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CTTNBP2 OR2L5 ARMH1 GFRA3 KCNH2 CMA1 ADAMTS7

2.04e-0518020572658a6be43d6d94767b4fc5af2d8632469a8a979
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

CTTNBP2 HK3 OR2L3 PLXNB2 NR1H3 NHSL1 SIGLEC1

2.04e-0518020577be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

ARMH1 NEK5 SPAG16 MAP3K19 CFAP47 DNAH2 PTPRT

2.19e-051822057fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PALD1 ETV1 FAM186B GALR2 SPARCL1 TMEM255A IRF8

2.27e-051832057c85a707acbcb582912e8ac080a36d05f91cfd7a2
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PALD1 CNTNAP3B SPTBN1 CNTNAP3 NPAS3 PTX3 FLT4

2.27e-0518320574d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PALD1 ETV1 FAM186B GALR2 SPARCL1 TMEM255A IRF8

2.27e-051832057262387ee8d43b96e5f1a77c75124459a506a6172
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CNTNAP3B CNTNAP3 PRSS51 RAPGEF3 PREX1 VWF LIMS2

2.35e-051842057a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|metastatic_Brain / Location, Cell class and cell subclass

CNTNAP3B SRCAP SPARCL1 FLT4 VWF TAMALIN LIMS2

2.43e-051852057ad52970e88e8947ef256095bd4b40229b912d58a
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_3|368C / Donor, Lineage, Cell class and subclass (all cells)

HK3 PNPLA6 FCGR1BP OAS1 NR1H3 APIP SIGLEC1

2.52e-051862057ddfadd43efeac3b3e6b7062590cc2b8f2f2db2ab
ToppCell10x5'-Lung-Mast|Lung / Manually curated celltypes from each tissue

CTTNBP2 ARMH1 GFRA3 KCNH2 RHOBTB3 ZBTB32 ADAMTS7

2.61e-051872057f8ac5ca5cbe9c6f3d8c0fffc20fe08ca1aea43c0
ToppCell10x5'-Lung-Mast-Mast_cells|Lung / Manually curated celltypes from each tissue

CTTNBP2 ARMH1 GFRA3 KCNH2 RHOBTB3 ZBTB32 ADAMTS7

2.61e-051872057da275d2c774b3e6a8ed77f777dd0676ecf2ddd2c
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Adult / Lineage, Cell type, age group and donor

PALD1 SPTBN1 SPARCL1 BCAR3 PREX1 FLT4 TAMALIN

2.70e-051882057e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCellControl-Endothelial_cells|Control / group, cell type (main and fine annotations)

PALD1 SPTBN1 SPARCL1 PREX1 VWF TAMALIN LIMS2

2.70e-0518820573953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B CNTNAP3 SPARCL1 TMEM225 VWF LIMS2 UNC13C

2.79e-0518920577346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B NPAS3 SPARCL1 VWF LIMS2 TIAM1

2.89e-051902057656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CNTNAP3 RAPGEF3 SPARCL1 VWF TAMALIN LIMS2 LIMCH1

2.99e-051912057adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B SPARCL1 PREX1 FLT4 VWF LIMS2

3.09e-051922057c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B SPARCL1 PREX1 FLT4 VWF LIMS2

3.19e-05193205752e918884877b6659cdca0496390e440f73694a9
ToppCellAdult-Endothelial|Adult / Lineage, Cell type, age group and donor

PALD1 CNTNAP3B SPTBN1 FLT4 VWF TAMALIN LIMS2

3.30e-051942057963b3fbee0575af8379baa397ace65949eaf34f7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2

3.30e-051942057f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2

3.30e-051942057a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2

3.30e-051942057f76808666fb875fc787751cbfd924d9be20a8192
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

PALD1 SPTBN1 SPARCL1 FLT4 VWF LIMS2 MACF1

3.41e-051952057a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPTBN1 ETV1 FAP TIAM1 SLIT3 MACF1 UNC13C

3.41e-0519520570e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B SPTBN1 FLT4 VWF TAMALIN LIMS2

3.52e-0519620578ad8efb631164b46f0c082572270188e5ead20bf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 CNTNAP3B SPTBN1 FLT4 VWF TAMALIN LIMS2

3.52e-0519620579606ea7e42f707e69ea891b3521037613b9675f5
ToppCellEndothelial|World / Lineage, Cell type, age group and donor

PALD1 CNTNAP3B SPTBN1 FLT4 VWF TAMALIN LIMS2

3.52e-05196205796c6d78482a130ce4e29f6629972a06d10d7530e
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CNTNAP3 BOK KCNH2 SPARCL1 FLNA RHOBTB3 SLIT3

3.64e-051972057398a66c06df63567b176ab2cc85e27837e94d0d9
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

CTTNBP2 SPTBN1 SPARCL1 TIAM1 SLIT3 MACF1 UNC13C

3.64e-05197205731a1852911bda38543916585fda34255fd62a134
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2

3.64e-051972057cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PALD1 CNTNAP3B SPTBN1 SPARCL1 FLT4 VWF LIMS2

3.64e-051972057ebf9be068eaa658493fa7884fd19f34642922acb
ToppCell3'-Child09-12-SmallIntestine-Endothelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CNTNAP3 FAP SPARCL1 FLT4 VWF LIMS2 LIMCH1

3.64e-05197205786a02fd7b4762b3278e5e60b5483b5fc1206e597
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2

3.64e-051972057412cb5f37df57121ddd1492021445479c7cbccbf
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

HK3 PNPLA6 PREX1 DOCK2 DOK2 ASGR2 SIGLEC1

3.75e-051982057ea34096bee852a7e996f097fa279381afa8f86ff
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 TAMALIN LIMS2 LIMCH1

3.75e-05198205731ba87552be97c9b78c9e82f98e96699ccb19824
ToppCell5'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CNTNAP3 RAPGEF3 SPARCL1 FLT4 VWF TAMALIN LIMCH1

3.75e-05198205790e85fe7a0ab376a41666dfff6c0e95b7f1c9475
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2

3.75e-051982057440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCell3'-Child04-06-SmallIntestine-Endothelial|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPTBN1 CNTNAP3 RAPGEF3 SPARCL1 FLT4 VWF LIMCH1

3.75e-051982057bf4e086c3fc924e999b6eaca87d2beee9b9526c2
ToppCellproximal-3-Hematologic-Alveolar_Macrophage|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HK3 PNPLA6 FCGR1BP IRF8 OAS1 DOK2 SIGLEC1

3.75e-051982057a5daf11bf7fe614be9f4a0fc6a4b37b5dce2f6fc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2

3.75e-051982057451003a21162eeae90739fdb502bb50b362d80c8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 SPTBN1 PREX1 FLT4 TAMALIN LIMS2 NHSL1

3.75e-05198205792416e65a0dc1a4bf931833407620ea05d362f56
ToppCellproximal-Hematologic-Alveolar_Macrophage-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HK3 PNPLA6 FCGR1BP IRF8 OAS1 DOK2 SIGLEC1

3.75e-051982057a5deecd8809bc5b38ffda02143598ad0145e2559
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

PALD1 SPTBN1 SPARCL1 PREX1 VWF TAMALIN LIMS2

3.75e-05198205745419f2804b4be79bae6632e71c54e1af482d115
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

EXT1 NCOA2 MAP4K3 SIK3 FAF1 NHSL1 LIMCH1

3.75e-0519820571996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SPTBN1 CNTNAP3 RAPGEF3 SPARCL1 FLT4 VWF LIMCH1

3.75e-05198205713203249e5743ba2699871c184d141207e550a86
ToppCellproximal-Hematologic-Alveolar_Macrophage|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HK3 PNPLA6 FCGR1BP IRF8 OAS1 DOK2 SIGLEC1

3.75e-051982057ec0092ef6207e788e2c20ddf007a2f6f6e351d0b
ToppCelldistal-mesenchymal-Alveolar_Fibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ETV1 FAP PTX3 SPARCL1 SLIT3 MACF1 LIMCH1

3.88e-05199205728c1722deef3b8347371c7359be7c64b95780de3
ToppCellParenchymal-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PALD1 CNTNAP3B SPARCL1 FLT4 VWF TAMALIN LIMS2

3.88e-051992057a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN1 SPARCL1 FLT4 VWF TAMALIN LIMS2 LIMCH1

3.88e-0519920578b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN1 SPARCL1 FLT4 VWF TAMALIN LIMS2 LIMCH1

3.88e-051992057da5a88749d859d535daa030d0974485906cc0ba7
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

EXT1 NCOA2 MAP4K3 DTNB SIK3 FAF1 LIMCH1

3.88e-05199205794b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

CNTNAP3B SPTBN1 RAPGEF3 SPARCL1 VWF TAMALIN LIMS2

3.88e-051992057793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCellKidney-Endothelial|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

PALD1 SPTBN1 PREX1 FLT4 VWF TAMALIN LIMS2

3.88e-051992057b543f0686522df43737e9ffa5c9733e42b8a9f4d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTBN1 SPARCL1 FLT4 VWF TAMALIN LIMS2 LIMCH1

4.00e-052002057b1be27d134a8633e3e7862c6a0d7be2001d387f0
ToppCellTracheal-10x5prime-Endothelial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SPTBN1 RAPGEF3 SPARCL1 FLT4 VWF TAMALIN LIMS2

4.00e-05200205771ba0e48ca4ded077f2b96a0cf4f2331f2e25d15
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SPTBN1 SPARCL1 VWF CASP10 LIMS2 MACF1 FGD6

4.00e-052002057dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellfacs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP8 FCGR1BP KCNJ5 ADAMTS7 GALNT9 SLC28A1

4.70e-051402056115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCellfacs-Thymus-nan-3m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP8 FCGR1BP KCNJ5 ADAMTS7 GALNT9 SLC28A1

4.70e-05140205622d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCellfacs-Thymus-nan-3m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP8 FCGR1BP KCNJ5 ADAMTS7 GALNT9 SLC28A1

4.70e-05140205662d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCelldroplet-Pancreas-Exocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGR1BP DOK2 TIAM1 SAMD11 ASGR2 FHOD1

5.09e-051422056bf4a9633d128805a0d7e426d6fe6c29db1ff8c81
ToppCellSevere-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

OR2L3 MAP3K19 BAHCC1 VWF LIMS2 MEGF10

5.71e-051452056a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCellfacs-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HK3 SARS2 FCGR1BP SDAD1 ZBTB32 GALNT9

5.94e-05146205626493014daa432db721613ef480d133f3da9eb58
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HK3 PREX1 DOCK2 DOK2 ALPK1 SIGLEC1

6.40e-051482056bbf4933582b50b3412c805de5ed137107c996236
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HK3 PREX1 DOCK2 DOK2 ALPK1 SIGLEC1

6.40e-05148205679e376503a3f9504a1ec5af4a60a09cc80e19059
ToppCellfacs-Pancreas-Exocrine-3m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HK3 PREX1 DOCK2 DOK2 ALPK1 SIGLEC1

6.40e-0514820566543860e3207a7de92a35bb6004be51287582f7a
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_VISp_Trhr_Cpne7|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ETV1 EFR3A RAPGEF3 SPAG16 GRB7 FGD6

6.64e-0514920568638b3819193d11411df58964069fec583f617f4
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-NP|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ETV1 EFR3A RAPGEF3 SPAG16 GRB7 UNC13C

6.90e-0515020562ba55e51877e2e749cccdae7df5d885dc55b2587
ToppCell10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-myeloid_DC_progenitor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MYH6 KIF25-AS1 BAHCC1 IRF8 DDX25 CDK4

7.42e-051522056bffbbdf1047c59e5241c99dc10b36cfe2071aa48
ToppCellfacs-Marrow-T-cells-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLXNB2 FCGR1BP FLNA NR1H3 ASGR2 GALNT9

7.42e-0515220563b59143b2b4ee24eb6378f87ff568124193256e9
DrugPromethazine hydrochloride [58-33-3]; Down 200; 12.4uM; HL60; HT_HG-U133A

GPRASP1 SRCAP STAT2 PHKA2 PLA2G6 CHPF RHOBTB3 OAS1 TRMU ASGR2

9.23e-06193202103100_DN
DrugKawain [500-64-1]; Down 200; 17.4uM; PC3; HT_HG-U133A

SPTBN1 ALDH3A1 AGPAT2 NR1H3 URGCP ZNF668 HEATR6 TIAM1 FHOD1 FGD6

1.06e-05196202107369_DN
DrugCyclosporin A [59865-13-3]; Down 200; 3.4uM; PC3; HT_HG-U133A

DOHH ITPKA URB1 RRP12 AGPAT2 OAS1 ALPK1 XRCC3 TIAM1 MAPK8IP2

1.06e-05196202104586_DN
DrugPrilocaine hydrochloride [1786-81-8]; Up 200; 15.6uM; MCF7; HT_HG-U133A

SRCAP OR2B6 KCNH2 PTX3 TAB1 DTNB IRF8 CASP10 LIMS2 LIMCH1

1.21e-05199202104749_UP
DrugHomosalate [118-56-9]; Up 200; 15.2uM; PC3; HT_HG-U133A

DOHH GALK2 SPTBN1 GALR2 KCNJ5 CASP10 CRKL KANSL3 SIGLEC1 RBM34

1.21e-05199202104533_UP
DrugSaquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A

INPP5B SPTBN1 SRCAP PHKA2 PNPLA6 KCNH2 PLA2G6 ALDH3A1 SIGLEC1 ZNF304

1.26e-05200202106246_UP
DiseaseProteinuria

VWF ADAMTS7 UNC13C

1.24e-04151963HP_0000093
Diseasecortical thickness

PALD1 GALK2 CTTNBP2 ABO KMT2B NUP210L SPTBN1 EXT1 SP8 PMPCA USP35 AGAP3 NCOA2 FAF1 NHSL1 ZBTB32 ADAMTS7 SETD5 MACF1

1.69e-04111319619EFO_0004840
Diseaseplatelet component distribution width

ABO NUP210L ZZEF1 RAPGEF3 EXOC3L4 PLA2G6 SNX9 PREX1 FLT4 VWF DOK2 CRKL MACF1 SIGLEC1 FGD6

1.71e-0475519615EFO_0007984
Diseaseresponse to methotrexate, neurotoxicity

GIPC1 PNPLA6 MACF1

2.59e-04191963EFO_0011057, GO_0031427
Diseasedihydrofolate reductase measurement

ABO VWF

2.61e-0441962EFO_0801526
DiseaseMalignant neoplasm of breast

HK3 CLPTM1L OTOGL KCNH1 BCAR3 HERC2 NCOA2 FLNA VWF FRMPD1 IRF8 GRB7 SIK3 XRCC3 ZNF668 SLC28A1 MACF1 ZFYVE26

3.14e-04107419618C0006142
Diseasestroke, coronary artery disease

ABO PEMT ADAMTS7

3.51e-04211963EFO_0000712, EFO_0001645
Diseasenevus count, cutaneous melanoma

PLXNB2 CLPTM1L PLA2G6 HERC2 DTNB

3.60e-04911965EFO_0000389, EFO_0004632
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

ABO PMPCA PLA2G6 NR1H3 SIK3 FAF1 MACF1

3.98e-042001967EFO_0004611, EFO_0020945
Diseasegallbladder carcinoma (is_implicated_in)

ABO CLPTM1L

4.33e-0451962DOID:4948 (is_implicated_in)
Diseasebeta-1,4-galactosyltransferase 1 measurement

ABO B4GALT1

4.33e-0451962EFO_0801409
DiseaseMacrothrombocytopenia

TRPM7 FLNA

4.33e-0451962C2751260
DiseaseSick Sinus Syndrome

MYH6 KCNJ5

6.47e-0461962C0037052
Diseasemacrophage colony-stimulating factor 1 receptor measurement

ABO B4GALT1

6.47e-0461962EFO_0020547
Diseaseunipolar depression, depressive symptom measurement

CTTNBP2 C12orf42 PREX1

6.70e-04261963EFO_0003761, EFO_0007006
Diseaseuromodulin measurement

ABO B4GALT1 ASGR2

6.70e-04261963EFO_0021778
Diseaselymphocyte:monocyte ratio

PALD1 ABO FAP RRP12 BCAR3 IRF8 NR1H3 RBM34

7.20e-042881968EFO_0600088
Diseasefactor VIII measurement, von Willebrand factor measurement

ABO TAB1 VWF

7.51e-04271963EFO_0004629, EFO_0004630
Diseasemultiple myeloma

SRCAP HERC2 PREX1 NCOA2 DTNB

9.28e-041121965EFO_0001378
DiseaseIschemic stroke, von Willebrand factor measurement

ABO TAB1 VWF

1.03e-03301963EFO_0004629, HP_0002140
DiseaseNonorganic psychosis

NPAS3 SP8 KCNH2 PLA2G6

1.17e-03691964C0349204
Diseaseprotein-tyrosine sulfotransferase 2 measurement

ABO SIK3

1.20e-0381962EFO_0801971
DiseaseFamilial melanoma

XRCC3 CDK4

1.20e-0381962cv:C1512419
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3

1.20e-0381962DOID:0060308 (implicated_via_orthology)
DiseaseMalignant melanoma of skin

XRCC3 CDK4

1.20e-0381962cv:C0151779
DiseaseMelanoma

XRCC3 CDK4

1.20e-0381962cv:C0025202
Diseasesemaphorin-3G measurement

ABO TAB1

1.20e-0381962EFO_0802049
Diseaseserum gamma-glutamyl transferase measurement

ABO TRPM7 NUP210L SLC28A3 EXOC3L4 CCDC97 SNX9 BAHCC1 OAS1 FAAP100 FAF1 APIP RP1L1 SIGLEC1 KDM1A

1.23e-0391419615EFO_0004532
Diseasecutaneous melanoma

PLXNB2 CLPTM1L PLA2G6 HERC2 DTNB

1.31e-031211965EFO_0000389
Diseaseesophagus squamous cell carcinoma (is_marker_for)

CLPTM1L FAP GRB7 SETD5

1.51e-03741964DOID:3748 (is_marker_for)
Diseasescavenger receptor cysteine-rich type 1 protein m130 measurement

B4GALT1 ASGR2

1.53e-0391962EFO_0020717
Diseaset-cell surface glycoprotein CD5 measurement

ABO B4GALT1

1.53e-0391962EFO_0803134
Diseaseresponse to clopidogrel, response to acetylsalicylate, major adverse cardiovascular event measurement

EFR3A AGAP3

1.53e-0391962EFO_0020863, GO_1903492, GO_1903493
Diseaseplexin-B2 measurement

ABO PLXNB2

1.53e-0391962EFO_0021867
Diseasefamilial melanoma (is_implicated_in)

XRCC3 CDK4

1.53e-0391962DOID:6846 (is_implicated_in)
Diseasecortical surface area measurement

PALD1 CTTNBP2 SPTBN1 NPAS3 EXT1 PLXNB2 SP8 PMPCA USP35 AGAP3 NCOA2 FAF1 CRKL NHSL1 ADAMTS7 RP1L1 MACF1 FGD6 KDM1A

1.65e-03134519619EFO_0010736
Diseaselung squamous cell carcinoma (is_marker_for)

CLPTM1L FAP CDK4

1.75e-03361963DOID:3907 (is_marker_for)
Diseasevascular endothelial growth factor receptor 3 measurement

ABO FLT4

1.91e-03101962EFO_0008315
Diseaseneuroimaging measurement

CTTNBP2 ABO KMT2B SPTBN1 EXT1 PLXNB2 SP8 BAHCC1 AGAP3 SH2D5 FAF1 NHSL1 ZBTB32 ARHGEF1 MACF1 FGD6

2.17e-03106919616EFO_0004346
Diseasepneumococcal bacteremia

ETV1 DOCK2

2.32e-03111962EFO_1001925
DiseaseCongenital long QT syndrome

KCNH2 KCNJ5

2.32e-03111962cv:C1141890
Diseasefactor VIII measurement

ABO TAB1 VWF

2.38e-03401963EFO_0004630
Diseasewaist circumference

TRPM7 PRSS51 TAB1 SPAG16 PREX1 PTPRT TIAM1 SLIT3 UNC13C

2.40e-034291969EFO_0004342
Diseasecholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

ABO SLC28A3 PEMT PMPCA PLA2G6 SIK3 MACF1

2.57e-032761967EFO_0004612, EFO_0020943
Diseasevenous thromboembolism, von Willebrand factor measurement

ABO TAB1 VWF

2.74e-03421963EFO_0004286, EFO_0004629
Diseasewaist-hip ratio, body mass index

EFR3A DOCK2

2.77e-03121962EFO_0004340, EFO_0004343
DiseaseLong QT syndrome

KCNH2 KCNJ5

2.77e-03121962cv:C0023976
Diseasetotal blood protein measurement

ABO SLC28A3 C4orf17 FCGR1BP PMPCA NCOA2 MAP4K3 MACF1 SIGLEC1

3.25e-034491969EFO_0004536
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

ABO PEMT PMPCA PLA2G6 NR1H3 SIK3 MACF1

3.44e-032911967EFO_0008317, EFO_0020946
Diseasemean platelet volume

GALK2 ABO NUP210L SPTBN1 PSMD13 SRCAP SP8 EXOC3L4 VWF DOK2 SIK3 CRKL TRMU GALNT9 CDK4

3.50e-03102019615EFO_0004584
Diseasedystonia (is_implicated_in)

KMT2B SHQ1

3.79e-03141962DOID:543 (is_implicated_in)
Diseaseatrial fibrillation (is_implicated_in)

KCNJ5 VWF

3.79e-03141962DOID:0060224 (is_implicated_in)
DiseaseQRS duration

NPAS3 SP8 HEATR5B CHPF IRF8 FAF1 MEGF10

3.91e-032981967EFO_0005055
DiseaseParoxysmal atrial fibrillation

MYH6 KCNH2 KCNJ5 VWF SLIT3

3.95e-031561965C0235480
Diseasefamilial atrial fibrillation

MYH6 KCNH2 KCNJ5 VWF SLIT3

3.95e-031561965C3468561
DiseasePersistent atrial fibrillation

MYH6 KCNH2 KCNJ5 VWF SLIT3

3.95e-031561965C2585653
Diseasemyopathy (implicated_via_orthology)

MYH6 FLNA MEGF10

4.01e-03481963DOID:423 (implicated_via_orthology)
DiseaseSinus Node Dysfunction (disorder)

MYH6 KCNJ5

4.35e-03151962C0428908
DiseaseAtrial Fibrillation

MYH6 KCNH2 KCNJ5 VWF SLIT3

4.40e-031601965C0004238
DiseasePsychotic Disorders

NPAS3 SP8 KCNH2 PLA2G6

4.67e-031011964C0033975
Diseaseretinal drusen

C12orf42 VWF UNC13C

4.76e-03511963EFO_1001155
DiseaseRomano-Ward Syndrome

KCNH2 KCNJ5

4.95e-03161962C0035828
Diseaserevision of total joint arthroplasty, aseptic loosening

ABO SLC28A1

4.95e-03161962EFO_0010725, EFO_0020974
Disease1-Methylhistidine measurement

OTOGL NCOA2

5.59e-03171962EFO_0021543
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

ABO PEMT PMPCA PLA2G6 SIK3 MACF1

5.84e-032431966EFO_0004612, EFO_0020944
DiseaseMalignant mesothelioma

GPR27 AGO1 LIMCH1 FGD6

6.11e-031091964C0345967
Diseasevon Willebrand factor measurement

ABO TAB1 VWF

6.18e-03561963EFO_0004629
Diseasesuperior frontal gyrus volume measurement

PALD1 ZNF792

6.26e-03181962EFO_0010329

Protein segments in the cluster

PeptideGeneStartEntry
RLCSFRNASEVPMVL

AGAP3

181

Q96P47
DPTAFARRAMDVCLL

EXOC3L4

171

Q17RC7
GPAFSECLERRQMLH

BAHCC1

331

Q9P281
RCFSQPRHISVAMDK

B4GALT1

261

P15291
RVLHDLFFQPMAECL

ARHGEF1

436

Q92888
VTVRGHVAPMARCAA

CNTNAP3

1191

Q9BZ76
ADCFLMRNHTITEQP

ARSL

251

P51690
FCMAVREPDHLQRVS

ABO

51

P16442
RRNTMARHADNCAGP

CTCF

566

P49711
GSQPACLDHMQDRRA

BCAR3

316

O75815
VIAQHVLSMDCRVAR

BCAR3

551

O75815
KHFPVDLRFVACQME

ASGR2

151

P07307
FPDTSMEAIRLIRHC

ARFGEF1

1336

Q9Y6D6
TFSHRRSCLVRPLMN

ALDH3A1

421

P30838
CFVQMFPLVAEHVRK

ARMH1

351

Q6PIY5
RRIHTGERPFMCNAC

GZF1

566

Q9H116
MDAHPSRYCATVRVQ

AGO1

616

Q9UL18
CSMPKFIRFLHDSVR

AADACL4

66

Q5VUY2
RLPTAEVMFCTLNTH

GIPC1

91

O14908
FLSRHRACVPLQMAR

FAM186B

831

Q8IYM0
PVLQHCMRILGEFRS

DNHD1

1071

Q96M86
DCVRQAQPAMVHALV

BOK

136

Q9UMX3
HSIRIQRALPSECQM

DDX25

261

Q9UHL0
HLEPTCAAMEAAVRA

DUSP28

81

Q4G0W2
AAALARCTENPMVRH

DOHH

226

Q9BU89
SAIINEDNLPMFHRC

EFR3A

581

Q14156
RPSFRHVQCSHFDAM

ADAMTS7

596

Q9UKP4
NEICHRLSLTRPSME

ALPK1

1226

Q96QP1
RAINHFFCDVPAMLT

OR2L2

171

Q8NH16
RAINHFFCDVPAMVT

OR2L3

171

Q8NG85
HFLDCGSIMAVRIVR

RBM34

306

P42696
MQEVFSQHRRACPGL

PALD1

606

Q9ULE6
EHRTSCLLFMGRVAN

SERPIND1

481

P05546
CLMFRVGDLRNSHIV

KCNJ5

216

P48544
SSCILREEARMPHSA

NR1H3

36

Q13133
QREAFHAMAACRRLV

MON1B

356

Q7L1V2
CATSPHVNNRDRMTV

MEGF10

936

Q96KG7
VNHFLPGLRCLRTDM

RELCH

1131

Q9P260
SRVFMEGEPLALRCH

FCGR1BP

111

Q92637
QERPSDDHFVQIMCI

PATL1

576

Q86TB9
AAHTVAARMSPFVRQ

PNPLA6

626

Q8IY17
LHETSMEQLFPRRCT

MAP4K3

591

Q8IVH8
AVMSFDRFVAICRPL

OR2B6

116

P58173
FAVTMRPTEASERCH

DOK2

151

O60496
RHSLSDPNMREFILC

NRBP2

271

Q9NSY0
QRCHLVIDEQPLMFR

LIMS2

141

Q7Z4I7
VQRMAEHVSCHPRYR

LPAR2

216

Q9HBW0
AAAVAAGLRRRFCHM

NFU1

11

Q9UMS0
FRFRHQMALVPCVLT

TRMU

331

O75648
AMRLAHRGCNVDTPV

LRR1

106

Q96L50
HFSRMNCDKPRLIEA

HERC2

3081

O95714
SMEVLPCSRVAHIER

GALNT9

366

Q9HCQ5
APMCLLANVAHANRV

KRT38

41

O76015
RAEVMQRPCTCDFLH

KCNH2

56

Q12809
RFACHVFVSQESMRP

MAPK8IP2

781

Q13387
MLHAVAASRLPVCSQ

CCDC97

66

Q96F63
LRHFESENIMSPACV

NHSL1

391

Q5SYE7
CLPAVMLAARRAAAA

GPR27

71

Q9NS67
GIVRAHMEDSCPQFL

PLXNB2

656

O15031
QVFRMFPDICASHQR

IRF8

401

Q02556
RAINHFFCDVPAMLT

OR2L5

171

Q8NG80
RAINHFFCDVPAMVT

OR2L8

171

Q8NGY9
ETIMDPRACRHAVIA

OR14J1

131

Q9UGF5
FSHMLICRAGAPASR

NEK5

276

Q6P3R8
PMDHRFRRQLSEPCN

ETV1

181

P50549
ATSHFNIRVMECRLA

GALK2

236

Q01415
QSDPEVRRAAVHCMA

HEATR6

176

Q6AI08
HRRAFTPFSVMIACS

HEATR6

501

Q6AI08
NPFLQSVHRCMTSRL

MED15

746

Q96RN5
RALAMEFQTVHCAPG

KCNH1

591

O95259
VCRHAAVALGQARAM

KMT2B

871

Q9UMN6
RHPTCKIQTLMFRNA

NLRP5

806

P59047
ENHDFRAMCPLCRDV

RFPL4B

41

Q6ZWI9
CLMEMTFTRPANHRQ

PSMD13

276

Q9UNM6
LPDTCFRMQINHAID

OAS1

21

P00973
QRHGMFLVRDSSTCP

CRKL

31

P46109
VRVMIARDPSTCHLA

KIF25-AS1

136

Q9Y6Z4
PQATVASACRFALRM

MROH1

1506

Q8NDA8
PLSRHTVDMLQCLRF

FAAP100

641

Q0VG06
ERHPRFCSVLQGTVM

HK3

431

P52790
MVTFVCRVHESSPAQ

TAMALIN

131

Q7Z6J2
FLQSCHLRMLTDPVD

MMACHC

66

Q9Y4U1
GATARHVCEMLVQRA

GRB7

121

Q14451
IGQFHCRVREMFSQL

MACF1

5126

Q9UPN3
RLMADALRGCVPAFH

ITPKA

221

P23677
LMARLSFCADNTIPH

OR1F2P

161

Q96R84
DIIHRIFRICNMARP

PTPRT

1311

O14522
LRSHCFTQAMLSQPR

PEMT

66

Q9UBM1
NIIRVPMASCDFSIR

GBA

156

P04062
LRATRPAFMCHRRQA

PRDM9

66

Q9NQV7
APRRRAMDICTFVFS

GALR2

181

O43603
MPAATVDHSQRICEV

CNOT7

1

Q9UIV1
EHMRRFLQCAEQVQP

CHCHD5

81

Q9BSY4
AAISCLQQLHMFAPR

HEATR5B

1046

Q9P2D3
SRLPHDRMTSQEAAC

KDM1A

181

O60341
QLDSVCTLHRMDIFP

CARD14

906

Q9BXL6
VSDNLRPFHDRMEEC

DOCK2

1591

Q92608
EMLHNATFCLVPRGR

EXT1

326

Q16394
PDMLRHIFQFCVLES

BTAF1

561

O14981
QYPSTAVRHMAARCV

BTAF1

1116

O14981
HPEAAVRVVQSMARF

CPLANE1

931

Q9H799
CRSRLVDFQTHCHPM

GFRA3

261

O60609
FEHPNVVRLMDVCAT

CDK4

66

P11802
HRQMAAGFSCEIVRA

CTTNBP2

1146

Q8WZ74
HVLCNSEDIRLSPFM

FLNA

646

P21333
SSCRHVIRMDQSPEE

FRMPD1

1471

Q5SYB0
GEPRVKHFEARSCMR

DHCR24

441

Q15392
GSHIMARNVSCFLVR

C4orf17

16

Q53FE4
FQRMHAPHRAPEVFC

TMEM132E-DT

46

A2RUQ5
HIERLMSFRPICSAN

CRYBA1

106

P05813
ARVQFHLMELNRSVC

FASTKD1

656

Q53R41
EHSVRTCFPQQRKIM

DTNB

191

O60941
SQTRMFLHEVARACP

INPP5B

116

P32019
ARSVMNECERHVIFA

KANSL3

96

Q9P2N6
EIMSHFTALQCPRLA

CASP10

376

Q92851
RPCVDCHAFEFMQRA

C4orf48

46

Q5BLP8
RARFLTMCNRHFGSV

FAF1

421

Q9UNN5
FRIHCQEARISPMSH

CCDC168

5506

Q8NDH2
QAAREVRIMQFCHTL

FHOD1

966

Q9Y613
RRIDRVMTCLAGAHF

DNAH2

556

Q9P225
RSDVVPMTAENFRCL

PPIE

161

Q9UNP9
EVMRRVHRAPSCKFV

RNASE11

126

Q8TAA1
MLRDGRFACAICPHR

SCNM1

36

Q9BWG6
MSSDRRLECIHFGPV

CFAP47

246

Q6ZTR5
TAAHCFRRTLLDMAV

PRSS51

76

A0A1B0GVH4
VRMCLTRDQHERPSA

MAP3K19

1301

Q56UN5
VTVRGHVAPMARCAA

CNTNAP3B

1191

Q96NU0
EHCQSILFSMLPRAS

PHKA2

236

P46019
MRCEEEAAVQPHSRA

LIMCH1

331

Q9UPQ0
FEVTMRRPVRNCTEH

OTOGL

1721

Q3ZCN5
LQVRFICAHPASMSV

NUP210L

751

Q5VU65
VPALVDTCHRAMRTT

AGPAT2

241

O15120
VHPVRPMRLESFSAC

PTX3

196

P26022
VPAHRAILVARCEVM

RHOBTB3

431

O94955
MVSNRTFSACHRFVP

OTOG

2311

Q6ZRI0
MNEYPDSCAVLVRRH

APIP

181

Q96GX9
ARHRAKREACIDFMP

GPRASP1

331

Q5JY77
PEKQNCRSMDRFSFH

KIF13B

646

Q9NQT8
HTVAFRDLPVRMVCS

SARS2

311

Q9NP81
CIHASADPRQVREMV

PMPCA

391

Q10713
MAAATRRVFHLQPCE

SLC4A11

1

Q8NBS3
TRMCRHPVISESEVF

SNX9

336

Q9Y5X1
VVPNSRLHQMCRVRD

MRPL50

111

Q8N5N7
RHLNTEPMEIFRNCV

STAT2

796

P52630
FCPRHEDMTLLVRNF

TAB1

351

Q15750
MRNLTQAAREVNCPH

TMEM255A

156

Q5JRV8
NHAVTERSLFCPLDM

SH2D5

371

Q6ZV89
LRATRPAFMCHRRQA

PRDM7

66

Q9NQW5
SPCMRQDPQVHSFIR

RHBDF1

476

Q96CC6
IVTMPHFEFRNICDT

PREX1

911

Q8TCU6
RRSCTPNAEVRHMIA

SETD5

351

Q9C0A6
RIPFFMSTECEHLIR

SIK3

281

Q9Y2K2
NVHDIMVSFGRRVLC

SHQ1

316

Q6PI26
RSRHLVMPEHQSRCE

SAMD11

116

Q96NU1
VMPEHQSRCEFQRGS

SAMD11

121

Q96NU1
ARNHVNRMCLAADVP

UBA2

121

Q9UBT2
VCFHRPQNEARSLMP

SPATA31D4

601

Q6ZUB0
PTINEVRIDCHMFVT

NPAS3

321

Q8IXF0
LHVAVMRNRFDCAIV

PLA2G6

321

O60733
MRNRFDCAIVLLTHG

PLA2G6

326

O60733
SCNHTVLDPDLRMTF

SDAD1

86

Q9NVU7
MVISACVLNFHRALP

SLC28A3

116

Q9HAS3
LHRIVCNMRTQFPDL

SRCAP

2021

Q6ZRS2
MTNLRTTHPHFVRCI

MYH6

661

P13533
RPDTLLTHVRMVCEA

URB1

2231

O60287
VFFEACGRQAHPVMR

RRP12

496

Q5JTH9
FACPVCNKRFMRSDH

SP8

416

Q8IXZ3
RQVPCVCAVRHMRSS

MRPL12

26

P52815
PQVIRDRVAHMEFCY

SPTBN1

606

Q01082
HCVEGRLAFAPVVMR

B4GALNT4

931

Q76KP1
KLRLMDPQACSHFRD

CMA1

166

P23946
ITMPTSHRLACFRDD

CLPTM1L

486

Q96KA5
TPDFLNRCRMHAISG

CHPF

621

Q8IZ52
RTSVPCSRFINHMKN

C12orf42

56

Q96LP6
PRRNSHTFNCRMLVK

NCOA2

191

Q15596
CTSRQLQARMPAHLR

RNF223

116

E7ERA6
LCMAPVHLRGFNVAD

SLIT3

241

O75094
VMCIVLRPSRVHNSE

FAP

21

Q12884
APCRRVSVEDMAHAA

URGCP

441

Q8TCY9
RVFMPSAQLCAALLH

RAPGEF3

426

O95398
VCFHRPQNEARSLMP

SPATA31D3

601

P0C874
RGASFMPLCVSAHNR

USPL1

766

Q5W0Q7
ECGRRFMQPVCLRVH

ZNF668

116

Q96K58
RFPHLVMLECTETNS

TAS1R1

711

Q7RTX1
HMIREDARGLTPRQC

UNC13C

1961

Q8NB66
ALNPRMTRFSEEACA

VWF

571

P04275
QVAAFCRSLHEMNPS

TIAM1

1001

Q13009
VLVCAGHEAFRTPAM

RP1L1

216

Q8IWN7
GHLVRANAARCPMSV

WDR97

496

A6NE52
LRASLVPMEHCITRF

SPARCL1

616

Q14515
EQLAELVHCMVFRFP

USP35

371

Q9P2H5
NIFRLHELPVSCVSM

SPAG16

346

Q8N0X2
IFCNMRRPAHADIKT

FLT4

796

P35916
AAVVREFEMSPRCAN

FGD6

991

Q6ZV73
RTEFMGNPEHRVCNL

SIGLEC1

86

Q9BZZ2
HMALFICTVDSRPLA

SIGLEC1

811

Q9BZZ2
QPALRARSFCREHMQ

SLC28A1

66

O00337
IPSMDAQAGQRRHVC

ZNF688

171

P0C7X2
CTAMPRSIVRAHTVN

TMEM225

196

Q6GV28
RERSMENVLLPCSQH

ZNF792

586

Q3KQV3
EPTRICFLMAHDALN

ZZEF1

2461

O43149
CPQRSRDFSAMTKHL

ZBTB32

406

Q9Y2Y4
SQMTHAEVRPFRCLP

ZNF304

241

Q9HCX3
IACNTHVAPRMHRLV

TBCCD1

296

Q9NVR7
GLSRRQMEVCVRHPD

WNT10A

66

Q9GZT5
QMEVCVRHPDVAASA

WNT10A

71

Q9GZT5
LQMEVTRFLHRCESA

ZFYVE26

2336

Q68DK2
VPGCHREMRRTASEQ

HIVEP1

1356

P15822
CTEDAFPHKRLQQLM

XRCC3

141

O43542
RPFVAHTCTQMLLSD

TRPM7

731

Q96QT4
PDCGRSFTQRAHMLL

ZNF467

191

Q7Z7K2
RVALNSREPHMCLVR

WDR43

361

Q15061
GPRSRMCEQRFSHEA

ZMAT1

346

Q5H9K5
SIAPMDVCVRHFLQA

AMDHD2

331

Q9Y303