Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	EGF_3	SELL THBD EYS C6 NCAN OTOG	2.60e-05	235	47	6	PS50026
Domain	EGF-like_dom	SELL THBD EYS C6 NCAN OTOG	3.59e-05	249	47	6	IPR000742
Domain	MANEC	MANSC1 SPINT1	3.71e-05	4	47	2	PF07502
Domain	MANSC_N	MANSC1 SPINT1	6.17e-05	5	47	2	IPR011106
Domain	MANEC	MANSC1 SPINT1	6.17e-05	5	47	2	SM00765
Domain	MANSC_dom	MANSC1 SPINT1	9.24e-05	6	47	2	IPR013980
Domain	MANSC	MANSC1 SPINT1	9.24e-05	6	47	2	PS50986
Domain	EGF	SELL THBD EYS NCAN	2.81e-04	126	47	4	PF00008
Domain	Sushi	SELL C6 NCAN	3.03e-04	52	47	3	PF00084
Domain	CCP	SELL C6 NCAN	3.39e-04	54	47	3	SM00032
Domain	SUSHI	SELL C6 NCAN	3.77e-04	56	47	3	PS50923
Domain	Sushi_SCR_CCP_dom	SELL C6 NCAN	3.97e-04	57	47	3	IPR000436
Domain	TIL	MUC5AC OTOG	4.03e-04	12	47	2	PF01826
Domain	C8	MUC5AC OTOG	4.03e-04	12	47	2	PF08742
Domain	EGF_1	SELL THBD EYS C6 NCAN	4.38e-04	255	47	5	PS00022
Domain	Unchr_dom_Cys-rich	MUC5AC OTOG	4.75e-04	13	47	2	IPR014853
Domain	C8	MUC5AC OTOG	4.75e-04	13	47	2	SM00832
Domain	EGF-like_CS	SELL THBD EYS C6 NCAN	4.87e-04	261	47	5	IPR013032
Domain	EGF_2	SELL THBD EYS C6 NCAN	5.22e-04	265	47	5	PS01186
Domain	TSP_1	ADAMTS17 C6 THSD7A	5.34e-04	63	47	3	PF00090
Domain	TIL_dom	MUC5AC OTOG	5.53e-04	14	47	2	IPR002919
Domain	TSP1	ADAMTS17 C6 THSD7A	5.85e-04	65	47	3	SM00209
Domain	TSP1_rpt	ADAMTS17 C6 THSD7A	5.85e-04	65	47	3	IPR000884
Domain	TSP1	ADAMTS17 C6 THSD7A	5.85e-04	65	47	3	PS50092
Domain	VWD	MUC5AC OTOG	7.27e-04	16	47	2	SM00216
Domain	VWF_type-D	MUC5AC OTOG	7.27e-04	16	47	2	IPR001846
Domain	VWFD	MUC5AC OTOG	7.27e-04	16	47	2	PS51233
Domain	VWD	MUC5AC OTOG	7.27e-04	16	47	2	PF00094
Domain	VWC_out	MUC5AC OTOG	1.03e-03	19	47	2	SM00215
Domain	Lectin_C	SELL THBD NCAN	1.23e-03	84	47	3	PF00059
Domain	CLECT	SELL THBD NCAN	1.23e-03	84	47	3	SM00034
Domain	C_TYPE_LECTIN_2	SELL THBD NCAN	1.28e-03	85	47	3	PS50041
Domain	C-type_lectin-like	SELL THBD NCAN	1.32e-03	86	47	3	IPR001304
Domain	CT	MUC5AC OTOG	1.39e-03	22	47	2	SM00041
Domain	Cys_knot_C	MUC5AC OTOG	1.79e-03	25	47	2	IPR006207
Domain	CTCK_2	MUC5AC OTOG	1.79e-03	25	47	2	PS01225
Domain	EGF_Ca-bd_CS	THBD EYS NCAN	1.87e-03	97	47	3	IPR018097
Domain	-	SELL THBD NCAN	1.87e-03	97	47	3	3.10.100.10
Domain	C-type_lectin-like/link	SELL THBD NCAN	1.98e-03	99	47	3	IPR016186
Domain	EGF_CA	THBD EYS NCAN	1.98e-03	99	47	3	PS01187
Domain	ASX_HYDROXYL	THBD EYS NCAN	2.04e-03	100	47	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	THBD EYS NCAN	2.40e-03	106	47	3	IPR000152
Domain	CTDL_fold	SELL THBD NCAN	2.47e-03	107	47	3	IPR016187
Domain	EGF	SELL THBD EYS NCAN	2.85e-03	235	47	4	SM00181
Domain	EGF_CA	THBD EYS NCAN	3.58e-03	122	47	3	SM00179
Domain	EGF-like_Ca-bd_dom	THBD EYS NCAN	3.74e-03	124	47	3	IPR001881
Domain	LDLR_class-A_CS	C6 SPINT1	4.55e-03	40	47	2	IPR023415
Domain	VWF_dom	MUC5AC OTOG	5.01e-03	42	47	2	IPR001007
Pubmed	Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer.	ZFHX3 MUC5AC	1.87e-06	2	48	2	17330845
Pubmed	METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.	RAG1 METTL16	5.59e-06	3	48	2	36608679
Pubmed	Plasminogen/thrombomodulin signaling enhances VEGF expression to promote cutaneous wound healing.	THBD PLG	5.59e-06	3	48	2	30341568
Pubmed	Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent.	SELL RAG1	5.59e-06	3	48	2	16682495
Pubmed	Plasmin and the thrombin-thrombomodulin complex both contribute to thrombin-activatable fibrinolysis inhibitor activation in whole blood model thrombi.	THBD PLG	1.12e-05	4	48	2	23140098
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	RAG1 GML THBD TRAF5 C6 MYO7B SRGAP3 IL9	1.57e-05	824	48	8	20237496
Pubmed	The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma.	RAG1 FHL2	3.90e-05	7	48	2	34076685
Pubmed	Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice.	MUC5AC IL9	3.90e-05	7	48	2	17487773
Pubmed	Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors.	RAG1 IL9	6.67e-05	9	48	2	29894691
Pubmed	Cytokine gene expression in murine fetal intestine: potential for extrathymic T cell development.	RAG1 IL9	8.33e-05	10	48	2	9619371
Pubmed	IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.	RAG1 IL9	1.44e-04	13	48	2	18997793
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS17 C6 THSD7A	1.55e-04	75	48	3	20637190
Pubmed	Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.	TRAF5 GRIN2B	1.68e-04	14	48	2	15749123
Pubmed	Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signalling components.	MUC5AC IL9	1.94e-04	15	48	2	25772331
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	THSD7A ARHGEF10 SRGAP3 KIAA0232	2.65e-04	225	48	4	12168954
Pubmed	Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.	RAG1 TRAF5 IL9	3.12e-04	95	48	3	20568250
Pubmed	Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.	RAG1 IL9	3.14e-04	19	48	2	30937919
Pubmed	Nephronophthisis-Related Ciliopathies	TMEM67 ZNF423	3.85e-04	21	48	2	27336129
Pubmed	Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen.	SELL THBD	4.23e-04	22	48	2	12871600
Pubmed	Little skate genome provides insights into genetic programs essential for limb-based locomotion.	SPINT1 FPGS	6.40e-04	27	48	2	36288084
Pubmed	Early embryonic expression of murine coagulation system components.	THBD PLG	1.02e-03	34	48	2	11154109
Pubmed	Joubert Syndrome	TMEM67 ZNF423	1.02e-03	34	48	2	20301500
Pubmed	The spatiotemporal expression pattern of Syndecans in murine embryonic teeth.	THBD NCAN	1.02e-03	34	48	2	32220631
Pubmed	Common genetic variants in candidate genes and risk of familial lymphoid malignancies.	RAG1 TRAF5 IL9	1.07e-03	145	48	3	19573080
Pubmed	Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.	RAG1 FPGS	1.14e-03	36	48	2	18830263
Cytoband	5p13	AGXT2 C6	1.44e-04	17	48	2	5p13
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELL THBD NCAN	4.66e-05	41	31	3	1298
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELL C6 NCAN	1.25e-04	57	31	3	1179
GeneFamily	LIM domain containing	FHL2 LPXN	4.58e-03	59	31	2	1218
GeneFamily	Ring finger proteins	PEX2 RAG1 TRAF5	1.14e-02	275	31	3	58
ToppCell	LAM-Epithelial-AirwayEpi\|Epithelial / Condition, Lineage and Cell class	TMEM67 C6 FHL2 SRGAP3 LRRC71	2.03e-06	193	48	5	f2672d2c495ee12c3b7d132452bde581fa5a7856
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	AGXT2 GRIN2B PLG NCAN	2.11e-05	151	48	4	3b4c57bad61e17a573e6f8dc6b917fba5fd56c43
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	THBD SRGAP3 FPGS LPXN	2.40e-05	156	48	4	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	Ciliated_cells-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	TMEM67 C6 LRRC71 CPEB1	2.92e-05	164	48	4	fd30c55d0d75ef8b9396435d836187168095152b
ToppCell	368C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	SELL ANKIB1 TMEM67 MCAT	3.44e-05	171	48	4	f3bf5805823d5733b58742172e7668725ce82931
ToppCell	droplet-Lung-nan-21m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL SEC24D MANSC1 SRGAP3	3.60e-05	173	48	4	8fb32a9f2dbec16de840d55b4db7e7718f5a2a7a
ToppCell	droplet-Lung-nan-21m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL SEC24D MANSC1 SRGAP3	3.60e-05	173	48	4	f663571aaae2365660a8b526c355f4bd1a124a74
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL SEC24D ARHGEF10 SRGAP3	4.11e-05	179	48	4	1757b9f3f4c634277a67c4f5a39d27d6b4937073
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THBD EYS MANSC1 THSD7A	4.29e-05	181	48	4	0ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRAF5 THSD7A CATSPERG ARHGEF10	4.48e-05	183	48	4	351d575339038bd4a66f408da518c567444208e8
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL SEC24D ARHGEF10 SRGAP3	4.67e-05	185	48	4	65dcb0a7ee64990a34a87c167b44497107f035ee
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ZFHX3 THBD TRAF5 FHL2	4.87e-05	187	48	4	387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ZFHX3 THBD TRAF5 FHL2	5.08e-05	189	48	4	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS17 EYS THSD7A NXPH2	5.29e-05	191	48	4	782bc7946417549ffd39e5b596db659436fa01ba
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Vein\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBD GRIN2B C6 ZNF423	5.40e-05	192	48	4	81baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Vein\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBD GRIN2B C6 ZNF423	5.40e-05	192	48	4	717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THBD GRIN2B C6 ZNF423	5.51e-05	193	48	4	7261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCell	11.5-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	ZFHX3 THBD TRAF5 FHL2	5.85e-05	196	48	4	05530fe7a5681c2f39b95016cd22ef99d6ac0430
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADAMTS17 EYS THSD7A NXPH2	6.33e-05	200	48	4	5ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADAMTS17 EYS THSD7A NXPH2	6.33e-05	200	48	4	e79d93d55b25804f2608185168da472301b6ebca
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ADAMTS17 EYS THSD7A NXPH2	6.33e-05	200	48	4	320d5a3a1e7da2fa8f1a164e29e180ec8ac9889c
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	SELL NXPH2 LRRC71	7.00e-05	74	48	3	06760e7179980685beddaaf7b14f4f9f932fe79c
Computational	Cell adhesion.	SELL THBD NCAN	9.55e-05	36	27	3	MODULE_410
Computational	Genes in the cancer module 96.	SELL THBD NCAN	1.04e-04	37	27	3	MODULE_96
Disease	mucinous adenocarcinoma (is_marker_for)	ZFHX3 MUC5AC	2.48e-05	5	47	2	DOID:3030 (is_marker_for)
Disease	NEPHRONOPHTHISIS 2	NXPH2 ZNF423	6.91e-05	8	47	2	C1865872
Disease	behavior	ZFHX3 CHCHD2P9 ZNF423	9.38e-05	55	47	3	GO_0007610
Disease	blood lead measurement	THSD7A FHL2 SRGAP3	1.62e-04	66	47	3	EFO_0007040
Disease	hippocampal sclerosis of aging	KCNMB3 THSD7A	6.15e-04	23	47	2	EFO_0005678
Disease	severe acute respiratory syndrome, COVID-19	ADAMTS17 ZFHX3 EYS THSD7A SRGAP3	7.09e-04	447	47	5	EFO_0000694, MONDO_0100096
Disease	Alzheimer's disease (is_marker_for)	SELL THBD GRIN2B SPINT1	7.47e-04	257	47	4	DOID:10652 (is_marker_for)
Disease	cerebral infarction (is_implicated_in)	AGXT2 THBD	9.81e-04	29	47	2	DOID:3526 (is_implicated_in)
Disease	triacylglycerol 56:7 measurement	AHCTF1 NCAN	9.81e-04	29	47	2	EFO_0010434
Disease	obsolete aging	ZFHX3 GRIN2B PLG ZNF25	1.01e-03	279	47	4	GO_0007568
Disease	proteinuria (implicated_via_orthology)	TMEM67 C6	1.05e-03	30	47	2	DOID:576 (implicated_via_orthology)
Disease	Complement deficiency disease	THBD C6	1.27e-03	33	47	2	C0272242
Disease	serum IgG glycosylation measurement	ADAMTS17 EYS THSD7A KIAA0232 ZNF423	1.43e-03	523	47	5	EFO_0005193
Disease	triacylglycerol 56:8 measurement	AHCTF1 NCAN	1.51e-03	36	47	2	EFO_0010435

Protein segments in the cluster

Peptide	Gene	Start	Entry
PDCCQAKDQYIEQFK	AGXT2	256	Q9BYV1
YFDCVNVNPEMPCFL	CATSPERG	906	Q6ZRH7
QQEFKIECAAYNPEP	ARHGEF10	891	O15013
IFCPAYDCFQLVPVD	ANKIB1	376	Q9P2G1
KPAPYRQCYQEVCND	ADAMTS17	1016	Q8TE56
ALCNFDPSKICYQEQ	NXPH2	201	O95156
PAKECPESLCQYSFN	RAG1	901	P15918
GNYFCQCVPPFKVVD	EYS	701	Q5T1H1
FQPNNSLICKYVPCE	LRRC53	566	A6NM62
LACFICPAVVNPEQY	GAPVD1	311	Q14C86
CKAGCQFPAYEDNPV	KIAA0232	1246	Q92628
QLPFCGPNELDNFYC	OR4Q3	166	Q8NH05
DNFYCDVPQVIKLAC	OR4Q3	176	Q8NH05
VFCKPQNICEVGFEY	PEX2	176	P28328
AKNCFAPQCPAYAII	LRRC71	521	Q8N4P6
RQPNCYLFFCPNEEA	MANSC1	91	Q9H8J5
YYGPQCQFVIQCEPL	SELL	186	P14151
IIYDFCMCNPPFFAN	METTL16	176	Q86W50
IFREQNDKTYCQPCF	LPXN	366	O60711
CLNKNQLPPICYNYE	MUC5AC	1651	P98088
NNKCPYFSCEQPCNQ	IL9	101	P15248
ENPVCEVSNYLFPDC	MCAT	221	Q8IVS2
QQPCFYGIKQFLECA	CHCHD2P9	111	Q5T1J5
LQEYAAKFDPCQCAP	C6	511	P13671
FIPKDNQNFCVPCYE	FHL2	141	Q14192
KLLQPCQFDYAVFCP	FPGS	426	Q05932
EAVQINPKCFYTPKC	KCNMB3	146	Q9NPA1
QPGPFFCRDQVCFKY	CPEB1	521	Q9BZB8
TFQEPENDPRNCCYL	AHCTF1	271	Q8WYP5
VINDFNCPNIRVCPY	GML	36	Q99445
PLYQCVCENFRCPQV	OTOG	2606	Q6ZRI0
FPFQQPEKCDNNQYF	TMEM67	41	Q5HYA8
VDPCFRANCEYQCQP	THBD	366	P07204
QQKLRSQYFFDCACP	SMYD4	586	Q8IYR2
IETQYCPCDKYNAQP	THSD7A	951	Q9UPZ6
PQLQKCFEAFENYQP	PIWIL2	831	Q8TC59
NDVPCNYNLPYVCKK	NCAN	1196	O14594
PENFPCKNLDENYCR	PLG	311	P00747
GFCNCVNDVPPFYFQ	SEC24D	386	O94855
QNHEENLCPEYPVFC	TRAF5	181	O00463
MCNQVFCPPLKFEFQ	SRGAP3	321	O43295
CLYEQNFVCKFAPRE	SPINT1	121	O43278
AAKVFQCLCEDQLYP	SLC12A3	476	P55017
PYECNQCEKSFYQKP	ZNF25	201	P17030
EYPCNQCDLKFSNFE	ZNF423	631	Q2M1K9
FPDPSLQCPNCQKFF	ZNF142	186	P52746
QLIPYQCDQCKLAFP	ZFHX3	2526	Q15911
NCQPYFIRCIKPNEY	MYO7B	646	Q6PIF6
CKSYNNPPCEENLFS	GRIN2B	946	Q13224