Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloendopeptidase activity

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

4.50e-09120417GO:0004222
GeneOntologyMolecularFunctionmetallopeptidase activity

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

1.53e-07200417GO:0008237
GeneOntologyMolecularFunctionendopeptidase activity

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

2.44e-05430417GO:0004175
GeneOntologyMolecularFunctionproteoglycan binding

LRP1 COL5A3 FCN2

1.56e-0451413GO:0043394
GeneOntologyMolecularFunctionpeptidase activity

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

3.34e-04654417GO:0008233
GeneOntologyMolecularFunctionsialic acid binding

SIGLEC9 FCN2

1.20e-0325412GO:0033691
GeneOntologyMolecularFunctionmetalloaminopeptidase activity

MMP16 MMP17

1.30e-0326412GO:0070006
GeneOntologyMolecularFunctionscavenger receptor activity

LRP1 VTN

1.40e-0327412GO:0005044
GeneOntologyMolecularFunctionpolysaccharide binding

VTN FCN2

1.84e-0331412GO:0030247
GeneOntologyMolecularFunctionzinc ion binding

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 ZRANB3

2.05e-03891417GO:0008270
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP13A5 ATP2A1

2.48e-0336412GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP13A5 ATP2A1

2.48e-0336412GO:0015662
GeneOntologyMolecularFunctionaminopeptidase activity

MMP16 MMP17

3.52e-0343412GO:0004177
GeneOntologyMolecularFunctioncarbohydrate binding

VTN FCER2 SIGLEC9 FCN2

3.67e-03310414GO:0030246
GeneOntologyMolecularFunctionsulfur compound binding

LRP1 COL5A3 VTN RYR2

4.25e-03323414GO:1901681
GeneOntologyBiologicalProcessextracellular matrix organization

MMP25 LRP1 ADAMTS10 COL5A3 VTN MMP2 MMP11 MMP16 MMP17 MMP19 ANGPTL7

1.27e-103774111GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

MMP25 LRP1 ADAMTS10 COL5A3 VTN MMP2 MMP11 MMP16 MMP17 MMP19 ANGPTL7

1.31e-103784111GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

MMP25 LRP1 ADAMTS10 COL5A3 VTN MMP2 MMP11 MMP16 MMP17 MMP19 ANGPTL7

1.35e-103794111GO:0045229
GeneOntologyBiologicalProcesscollagen catabolic process

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

9.02e-1053416GO:0030574
GeneOntologyBiologicalProcesscollagen metabolic process

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

4.51e-07148416GO:0032963
GeneOntologyBiologicalProcessextracellular matrix disassembly

LRP1 MMP2 MMP11 MMP19

1.47e-0575414GO:0022617
GeneOntologyBiologicalProcesspositive regulation of ATPase-coupled calcium transmembrane transporter activity

ATP2A1 RYR2

5.75e-056412GO:1901896
GeneOntologyCellularComponentextracellular matrix

MMP25 ADAMTS10 COL5A3 ANGPTL6 VTN MMP2 MMP11 MMP16 MMP17 MMP19 ANGPTL7 FCN2 WNT2

2.00e-106564113GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

MMP25 ADAMTS10 COL5A3 ANGPTL6 VTN MMP2 MMP11 MMP16 MMP17 MMP19 ANGPTL7 FCN2 WNT2

2.07e-106584113GO:0030312
GeneOntologyCellularComponentside of membrane

MMP25 LRP1 FCRLB FGF8 FCER2 MMP17 MMP19 SIGLEC9 FCN2 RYR2

5.39e-068754110GO:0098552
GeneOntologyCellularComponentcollagen-containing extracellular matrix

ADAMTS10 COL5A3 ANGPTL6 VTN MMP2 ANGPTL7 FCN2 WNT2

7.41e-06530418GO:0062023
GeneOntologyCellularComponentsarcoglycan complex

SGCD SGCG

5.60e-056412GO:0016012
GeneOntologyCellularComponentdystroglycan complex

SGCD SGCG

7.83e-057412GO:0016011
GeneOntologyCellularComponentexternal side of plasma membrane

LRP1 FCRLB FGF8 FCER2 SIGLEC9 FCN2

4.89e-04519416GO:0009897
GeneOntologyCellularComponentsarcoplasmic reticulum

ATP2A1 SGCD RYR2

6.85e-0488413GO:0016529
GeneOntologyCellularComponentdystrophin-associated glycoprotein complex

SGCD SGCG

6.97e-0420412GO:0016010
GeneOntologyCellularComponentglycoprotein complex

SGCD SGCG

1.09e-0325412GO:0090665
GeneOntologyCellularComponentcell surface

MMP25 LRP1 FCRLB FGF8 FCER2 MMP16 SIGLEC9 FCN2

1.24e-031111418GO:0009986
GeneOntologyCellularComponentGolgi lumen

VTN MMP11 MMP16

1.27e-03109413GO:0005796
GeneOntologyCellularComponentsarcoplasm

ATP2A1 SGCD RYR2

1.45e-03114413GO:0016528
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

ATP2A1 RYR2

3.52e-0345412GO:0033017
DomainHemopexin-like_dom

MMP25 VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.34e-1423397IPR000585
DomainHemopexin

MMP25 VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.34e-1423397PF00045
DomainHEMOPEXIN

MMP25 VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.34e-1423397PS00024
Domain-

MMP25 VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.34e-14233972.110.10.10
DomainHEMOPEXIN_2

MMP25 VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.34e-1423397PS51642
DomainHemopexin-like_repeat

MMP25 VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.34e-1423397IPR018487
DomainHX

MMP25 VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.34e-1423397SM00120
DomainPept_M10A

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

5.45e-1223396IPR021190
DomainM10A_MMP

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

5.45e-1223396IPR033739
DomainPeptidase_M10

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

7.25e-1224396PF00413
DomainZnMc

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

2.54e-1129396SM00235
DomainPeptidase_Metallo

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

2.54e-1129396IPR006026
DomainCYSTEINE_SWITCH

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

2.36e-1041396PS00546
DomainPept_M10A_stromelysin-type

MMP25 MMP11 MMP16 MMP17 MMP19

2.56e-1018395IPR016293
DomainMetalloPept_cat_dom

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

3.05e-1081397IPR024079
Domain-

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

3.05e-10813973.40.390.10
DomainPept_M10_metallopeptidase

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

3.19e-1043396IPR001818
DomainPG_binding_1

MMP25 MMP2 MMP16 MMP17 MMP19

4.61e-1020395PF01471
DomainPeptidoglycan-bd-like

MMP25 MMP2 MMP16 MMP17 MMP19

4.61e-1020395IPR002477
DomainZINC_PROTEASE

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

1.18e-0998397PS00142
DomainHemopexin_CS

VTN MMP2 MMP11 MMP16

3.79e-0817394IPR018486
DomainPept_M10A_Zn_BS

MMP2 MMP11 MMP16

3.76e-0615393IPR021158
Domain-

ANGPTL6 ANGPTL7 FCN2

1.65e-05243934.10.530.10
DomainFibrinogen_a/b/g_C_2

ANGPTL6 ANGPTL7 FCN2

1.65e-0524393IPR014715
DomainFibrinogen_C

ANGPTL6 ANGPTL7 FCN2

2.38e-0527393PF00147
DomainSarcoglycan_1

SGCD SGCG

2.54e-054392PF04790
Domain-

MMP2 MMP19

2.54e-0543921.10.101.10
DomainSarcoglycan

SGCD SGCG

2.54e-054392IPR006875
DomainFBG

ANGPTL6 ANGPTL7 FCN2

2.96e-0529393SM00186
Domain-

ANGPTL6 ANGPTL7 FCN2

3.29e-05303933.90.215.10
DomainFibrinogen_a/b/g_C_1

ANGPTL6 ANGPTL7 FCN2

3.29e-0530393IPR014716
DomainFibrinogen_a/b/g_C_dom

ANGPTL6 ANGPTL7 FCN2

4.00e-0532393IPR002181
DomainFIBRINOGEN_C_2

ANGPTL6 ANGPTL7 FCN2

4.00e-0532393PS51406
DomainFIBRINOGEN_C_1

ANGPTL6 ANGPTL7 FCN2

4.00e-0532393PS00514
DomainMethyltransf_11

METTL13 COQ3

5.01e-0416392PF08241
DomainMethyltransf_11

METTL13 COQ3

5.01e-0416392IPR013216
DomainCation_ATPase_N

ATP13A5 ATP2A1

6.36e-0418392PF00690
DomainCation_ATPase_N

ATP13A5 ATP2A1

6.36e-0418392SM00831
DomainATPase_P-typ_cation-transptr_N

ATP13A5 ATP2A1

7.10e-0419392IPR004014
DomainFibrinogen_CS

ANGPTL6 FCN2

7.10e-0419392IPR020837
Domain-

ATP13A5 ATP2A1

2.03e-03323922.70.150.10
Domain-

ATP13A5 ATP2A1

2.03e-03323923.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP13A5 ATP2A1

2.42e-0335392IPR023299
DomainATPase_P-typ_P_site

ATP13A5 ATP2A1

2.56e-0336392IPR018303
DomainP_typ_ATPase

ATP13A5 ATP2A1

2.56e-0336392IPR001757
DomainATPASE_E1_E2

ATP13A5 ATP2A1

2.56e-0336392PS00154
DomainATPase_P-typ_transduc_dom_A

ATP13A5 ATP2A1

2.70e-0337392IPR008250
DomainE1-E2_ATPase

ATP13A5 ATP2A1

2.70e-0337392PF00122
DomainHAD-like_dom

ATP13A5 ATP2A1

1.18e-0279392IPR023214
PathwayWP_MATRIX_METALLOPROTEINASES

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

1.59e-1129286MM15981
PathwayWP_MATRIX_METALLOPROTEINASES

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

1.99e-1130286M39652
PathwayWP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

3.07e-1046286M46450
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

MMP25 COL5A3 MMP2 MMP11 MMP16 MMP17 MMP19

1.93e-09114287MM14571
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

MMP25 MMP2 MMP11 MMP16 MMP17

4.84e-0933285M26976
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

MMP25 COL5A3 MMP2 MMP11 MMP16 MMP17 MMP19

8.15e-09140287M587
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

MMP25 MMP2 MMP11 MMP16 MMP17

1.02e-0838285MM14611
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

MMP25 COL5A3 VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.56e-08258288MM14572
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

MMP25 COL5A3 VTN MMP2 MMP11 MMP16 MMP17 MMP19

8.23e-08300288M610
PathwayREACTOME_COLLAGEN_DEGRADATION

COL5A3 MMP2 MMP11 MMP19

7.29e-0664284M26953
PathwayREACTOME_COLLAGEN_DEGRADATION

COL5A3 MMP2 MMP11

1.54e-0453283MM14566
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

SGCD SGCG RYR2

4.14e-0474283M39462
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

SGCD SGCG RYR2

4.14e-0474283M16376
PathwayKEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM

SGCD SGCG RYR2

5.80e-0483283M8728
PathwayKEGG_DILATED_CARDIOMYOPATHY

SGCD SGCG RYR2

7.34e-0490283M835
PathwayWP_COMPLEMENT_SYSTEM

VTN FCER2 FCN2

8.86e-0496283M39581
PathwayREACTOME_SYNDECAN_INTERACTIONS

COL5A3 VTN

1.29e-0327282M27217
Pubmed

Functional interactions between matrix metalloproteinases and glycosaminoglycans.

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

1.35e-132241623421805
Pubmed

Matrix metalloproteinases.

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

1.35e-132241610419448
Pubmed

Membrane-type matrix metalloproteinases: Their functions and regulations.

MMP25 MMP2 MMP16 MMP17

5.80e-11741425794647
Pubmed

Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.

MMP2 MMP11 MMP16 MMP17 MMP19

7.39e-112441515734845
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

MMP25 MMP2 MMP11 MMP16 MMP17

6.49e-103641520587546
Pubmed

Matrix metalloproteinases in tumor invasion.

MMP2 MMP11 MMP16 MMP17

2.99e-091641410949577
Pubmed

The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells.

LRP1 MMP16 MMP17

3.03e-08641314645246
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

STK38 MMP25 LRP1 ADAMTS10 MMP2 HCFC2 MMP11 MMP16 MMP17

1.45e-0773041934857952
Pubmed

Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes.

MMP16 MMP17 MMP19

2.49e-071141310949161
Pubmed

Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.

MMP25 MMP2 MMP19

5.49e-071441325636537
Pubmed

Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.

MMP2 MMP11 MMP16

8.42e-071641337701782
Pubmed

Genetic background influences muscular dystrophy.

SGCD SGCG

1.36e-06241216084087
Pubmed

Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain.

MMP2 MMP17

1.36e-06241210551873
Pubmed

Extraocular muscle is spared despite the absence of an intact sarcoglycan complex in gamma- or delta-sarcoglycan-deficient mice.

SGCD SGCG

1.36e-06241211257478
Pubmed

Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in Patients with Thyroid Nodules.

MMP25 MMP17

1.36e-06241238310435
Pubmed

Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A).

MMP2 MMP16

1.36e-06241217217338
Pubmed

Role of immunohistochemical overexpression of matrix metalloproteinases MMP-2 and MMP-11 in the prognosis of death by ovarian cancer.

MMP2 MMP11

1.36e-06241218208802
Pubmed

Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy.

SGCD SGCG

1.36e-06241214991064
Pubmed

Results in treatment of early breast cancers and the level of selected metalloproteinases.

MMP2 MMP11

1.36e-06241222286800
Pubmed

In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy.

MMP2 MMP11

1.36e-0624129508784
Pubmed

Secondary coronary artery vasospasm promotes cardiomyopathy progression.

SGCD SGCG

1.36e-06241214982859
Pubmed

SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy.

SGCD SGCG

1.36e-06241221138941
Pubmed

A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).

MMP2 MMP11 MMP16 MMP17 MMP19

2.66e-0618641520673868
Pubmed

Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.

MMP2 MMP11 MMP16 MMP17 MMP19

2.66e-0618641520452482
Pubmed

Expression of matrix metalloproteinases MMP-1, MMP-11 and MMP-19 is correlated with the WHO-grading of human malignant gliomas.

MMP11 MMP19

4.06e-06341217980449
Pubmed

Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.

MMP25 MMP2

4.06e-06341214583471
Pubmed

Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.

MMP2 MMP16

4.06e-06341218784838
Pubmed

Functional nitric oxide synthase mislocalization in cardiomyopathy.

SGCD SGCG

4.06e-06341214871549
Pubmed

Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex.

SGCD SGCG

4.06e-06341221665956
Pubmed

Inhibition of proteasome activity promotes the correct localization of disease-causing alpha-sarcoglycan mutants in HEK-293 cells constitutively expressing beta-, gamma-, and delta-sarcoglycan.

SGCD SGCG

4.06e-06341218535179
Pubmed

Differential requirement for individual sarcoglycans and dystrophin in the assembly and function of the dystrophin-glycoprotein complex.

SGCD SGCG

4.06e-06341210862711
Pubmed

Expression of the matrix metalloproteases 2, 14, 24, and 25 and tissue inhibitor 3 as potential molecular markers in advanced human gastric cancer.

MMP25 MMP2

4.06e-06341224669030
Pubmed

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle.

ATP2A1 SGCD

4.06e-06341221285509
Pubmed

Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells.

VTN MMP2

4.06e-0634129417058
Pubmed

Filamin 2 (FLN2): A muscle-specific sarcoglycan interacting protein.

SGCD SGCG

4.06e-06341210629222
Pubmed

Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone-induced tail resorption.

MMP2 MMP16

4.06e-06341211891989
Pubmed

Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9.

LRP1 MMP2

4.06e-06341219176371
Pubmed

Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release.

ATP2A1 RYR2

4.06e-06341224445321
Pubmed

Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.

MMP2 MMP11 MMP19

6.04e-063041322171010
Pubmed

Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2.

LRP1 VTN

8.12e-0644128626514
Pubmed

Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland.

MMP16 MMP17

8.12e-06441215895410
Pubmed

The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.

MMP25 MMP2

8.12e-0644128663332
Pubmed

Calpain 3 cleaves filamin C and regulates its ability to interact with gamma- and delta-sarcoglycans.

SGCD SGCG

8.12e-06441214506720
Pubmed

Cleavage of β-dystroglycan occurs in sarcoglycan-deficient skeletal muscle without MMP-2 and MMP-9.

MMP2 SGCG

8.12e-06441228821434
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

ATP2A1 RYR2

8.12e-0644129384575
Pubmed

Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E.

SGCD SGCG

8.12e-06441210678176
Pubmed

Molecular and genetic characterization of sarcospan: insights into sarcoglycan-sarcospan interactions.

SGCD SGCG

8.12e-06441210942431
Pubmed

Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding.

MMP2 MMP16

8.12e-06441224970228
Pubmed

Developmental expression of sarcoglycan gene products in cultured myocytes.

SGCD SGCG

8.12e-06441210448073
Pubmed

Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle.

SGCD SGCG

8.12e-06441225605665
Pubmed

Sarcoglycanopathies: can muscle immunoanalysis predict the genotype?

SGCD SGCG

8.12e-06441218996010
Pubmed

mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue.

MMP16 MMP17

1.35e-05541212661033
Pubmed

Expression of gamma -sarcoglycan in smooth muscle and its interaction with the smooth muscle sarcoglycan-sarcospan complex.

SGCD SGCG

1.35e-05541210993904
Pubmed

The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.

VTN MMP2

1.35e-05541218340378
Pubmed

Molecular organization of sarcoglycan complex in mouse myotubes in culture.

SGCD SGCG

1.35e-0554129864373
Pubmed

RA Acts in a Coherent Feed-Forward Mechanism with Tbx5 to Control Limb Bud Induction and Initiation.

FGF8 WNT2

1.35e-05541226212321
Pubmed

Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting.

SGCD SGCG

1.35e-05541216524571
Pubmed

Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy.

SGCD SGCG

2.03e-05641212189167
Pubmed

CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site.

LRP1 FCN2

2.03e-05641221054788
Pubmed

Matrix metalloproteinase activity in pediatric acute lung injury.

MMP2 MMP11

2.03e-05641219159011
Pubmed

The effect of epidermal growth factor on matrix metalloproteinases and tissue inhibitors of metalloproteinase gene expression in cultured human gingival fibroblasts.

MMP2 MMP11

2.03e-05641217181997
Pubmed

HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.

SGCD SGCG

2.84e-05741226929074
Pubmed

Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.

MMP2 MMP16

2.84e-05741219542530
Pubmed

Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.

MMP2 MMP16

2.84e-05741212879005
Pubmed

Sarcoglycan complex: implications for metabolic defects in muscular dystrophies.

SGCD SGCG

2.84e-05741219494113
Pubmed

Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation.

MMP2 MMP11

2.84e-05741210090151
Pubmed

Angiopoietin-like gene expression in the mouse uterus during implantation and in response to steroids.

ANGPTL6 ANGPTL7

2.84e-05741222350948
Pubmed

Common pathological mechanisms in mouse models for muscular dystrophies.

SGCD SGCG

2.84e-05741216306063
Pubmed

Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.

LRP1 OSBP

2.84e-05741229547901
Pubmed

Biochemical evidence for association of dystrobrevin with the sarcoglycan-sarcospan complex as a basis for understanding sarcoglycanopathy.

SGCD SGCG

2.84e-05741210767327
Pubmed

epsilon-sarcoglycan replaces alpha-sarcoglycan in smooth muscle to form a unique dystrophin-glycoprotein complex.

SGCD SGCG

3.78e-05841210488149
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

ATP2A1 RYR2

3.78e-05841219033399
Pubmed

Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes.

SGCD SGCG

3.78e-05841217164264
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

ATP2A1 RYR2

3.78e-05841211784029
Pubmed

Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation.

MMP2 MMP11

3.78e-0584128674412
Pubmed

Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy.

SGCD SGCG

3.78e-05841210481911
Pubmed

Fgf10 is essential for limb and lung formation.

FGF8 WNT2

4.86e-0594129916808
Pubmed

Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch.

MMP2 MMP11

4.86e-0594129108368
Pubmed

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.

ATP2A1 RYR2

6.07e-051041218434328
Pubmed

Genome-wide association analysis identifies susceptibility loci for migraine without aura.

LRP1 MMP17

6.07e-051041222683712
Pubmed

Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice.

MMP2 MMP11

7.41e-051141236465133
Pubmed

Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.

BRINP3 RYR2

7.41e-051141217903301
Pubmed

Basement membrane remodelling regulates mouse embryogenesis.

MMP25 MMP2

7.41e-051141232523119
Pubmed

Mouse model of muscleblind-like 1 overexpression: skeletal muscle effects and therapeutic promise.

ATP2A1 RYR2

7.41e-051141222846424
Pubmed

Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction.

FGF8 MMP11

8.88e-051241220034106
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS10 FGF8 MMP2

9.68e-057541320637190
Pubmed

Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.

MMP2 MMP11

1.05e-041341212815621
Pubmed

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.

LRP1 FGF8

1.05e-041341216207730
Pubmed

Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins.

SGCD SGCG

1.22e-041441222937058
Pubmed

uPARAP expression during murine lung development.

MMP2 MMP11

1.41e-041541218639653
Pubmed

ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.

ADAMTS10 MMP17

1.41e-041541238871984
Pubmed

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.

FGF8 RYR2

1.41e-041541217360443
Pubmed

Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.

FGF8 MMP2 MMP11 MMP16

1.58e-0423141421048031
Pubmed

Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum.

FGF8 MMP2

1.61e-041641227732850
Pubmed

Deletion of STK40 protein in mice causes respiratory failure and death at birth.

FGF8 WNT2

2.05e-041841223293024
Pubmed

Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos.

FGF8 WNT2

2.29e-041941223763947
Pubmed

ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.

MMP2 MMP11

2.29e-041941222014525
Pubmed

DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation.

FGF8 MMP2

2.81e-042141233871356
Pubmed

Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.

ATP2A1 RYR2

2.81e-042141228302382
Pubmed

DOT1L regulates dystrophin expression and is critical for cardiac function.

SGCD SGCG

2.81e-042141221289070
InteractionMMP17 interactions

LRP1 MMP2 MMP16 MMP17

2.77e-0910404int:MMP17
InteractionMMP16 interactions

LRP1 MMP11 MMP16 MMP17

3.99e-0818404int:MMP16
InteractionMMP8 interactions

MMP25 MMP2 MMP11 MMP16

1.63e-0725404int:MMP8
InteractionMMP11 interactions

MMP25 MMP11 MMP16

1.57e-0612403int:MMP11
InteractionMMP25 interactions

MMP25 MMP2 MMP11

2.04e-0613403int:MMP25
InteractionMMP24 interactions

MMP11 MMP16 MMP17

6.87e-0619403int:MMP24
InteractionMMP10 interactions

MMP2 MMP11 MMP16

2.83e-0530403int:MMP10
InteractionMMP13 interactions

LRP1 MMP11 MMP16

3.13e-0531403int:MMP13
InteractionSSPN interactions

SGCD SGCG

3.83e-055402int:SSPN
InteractionMMP1 interactions

MMP2 MMP16 MMP17

5.37e-0537403int:MMP1
InteractionWNT3A interactions

LRP1 TM9SF2 WNT2

1.25e-0449403int:WNT3A
InteractionMMP27 interactions

MMP2 MMP16

2.09e-0411402int:MMP27
Cytoband12q13.3

LRP1 NXPH4

9.65e-045141212q13.3
Cytoband19p13.2

ADAMTS10 COL5A3 ANGPTL6

1.14e-0322941319p13.2
CytobandEnsembl 112 genes in cytogenetic band chr9q34

NUP188 FCN2 AGPAT2

3.07e-03325413chr9q34
Cytoband9q34.3

FCN2 AGPAT2

4.08e-031064129q34.3
CytobandEnsembl 112 genes in cytogenetic band chr19p13

ADAMTS10 COL5A3 ANGPTL6 FCER2

5.49e-03797414chr19p13
CytobandEnsembl 112 genes in cytogenetic band chr12q13

LRP1 MMP19 NXPH4

6.39e-03423413chr12q13
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

2.00e-1224316891
GeneFamilyFibrinogen C domain containing

ANGPTL6 ANGPTL7 FCN2

1.02e-0525313554
GeneFamilyFibrinogen C domain containing|Angiopoietin like

ANGPTL6 ANGPTL7

7.92e-058312905
GeneFamilyEndogenous ligands

FGF8 VTN WNT2

7.63e-03237313542
CoexpressionNABA_MATRISOME

MMP25 ADAMTS10 COL5A3 FGF8 ANGPTL6 BRINP3 VTN MMP2 HCFC2 MMP11 MMP16 MMP17 MMP19 ANGPTL7 FCN2 WNT2

8.50e-1310084116MM17056
CoexpressionNABA_MATRISOME

MMP25 ADAMTS10 COL5A3 FGF8 ANGPTL6 BRINP3 VTN MMP2 HCFC2 MMP11 MMP16 MMP17 MMP19 ANGPTL7 FCN2 WNT2

1.11e-1210264116M5889
CoexpressionNABA_MATRISOME_ASSOCIATED

MMP25 ADAMTS10 FGF8 ANGPTL6 BRINP3 MMP2 HCFC2 MMP11 MMP16 MMP17 MMP19 ANGPTL7 FCN2 WNT2

3.04e-127384114MM17058
CoexpressionNABA_MATRISOME_ASSOCIATED

MMP25 ADAMTS10 FGF8 ANGPTL6 BRINP3 MMP2 HCFC2 MMP11 MMP16 MMP17 MMP19 ANGPTL7 FCN2 WNT2

3.84e-127514114M5885
CoexpressionNABA_ECM_REGULATORS

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

8.05e-08238417M3468
CoexpressionNABA_ECM_REGULATORS

MMP25 ADAMTS10 MMP2 MMP11 MMP16 MMP17 MMP19

9.02e-08242417MM17062
CoexpressionKATSANOU_ELAVL1_TARGETS_DN

STK38 COL5A3 METTL13 SGCD WNT2

3.30e-06147415M2387
CoexpressionKATSANOU_ELAVL1_TARGETS_DN

STK38 COL5A3 METTL13 SGCD WNT2

4.70e-06158415MM934
CoexpressionTRAVAGLINI_LUNG_ALVEOLAR_FIBROBLAST_CELL

MMP2 MMP19 SGCD SGCG WNT2

5.63e-06164415M41676
CoexpressionNABA_SECRETED_FACTORS

FGF8 ANGPTL6 BRINP3 HCFC2 ANGPTL7 WNT2

1.35e-05338416MM17064
CoexpressionNABA_SECRETED_FACTORS

FGF8 ANGPTL6 BRINP3 HCFC2 ANGPTL7 WNT2

1.47e-05343416M5883
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

LRP1 COL5A3 MMP2 SGCD SGCG

1.47e-05200415M5930
CoexpressionVERRECCHIA_DELAYED_RESPONSE_TO_TGFB1

MMP2 MMP11 MMP17

2.66e-0537413M16643
CoexpressionCHIBA_RESPONSE_TO_TSA_UP

VTN MMP11 MMP19

6.62e-0550413M10372
CoexpressionGAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS

LRP1 COL5A3 MMP2 MMP11 MMP19 SGCD

1.26e-04505416M39167
CoexpressionPETRETTO_BLOOD_PRESSURE_UP

NXPH4 RYR2

1.56e-0412412M14298
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HOPC

LRP1 BRINP3 MMP2 MMP16 SLC16A14

2.56e-04366415M39052
CoexpressionGSE22886_NAIVE_VS_IGG_IGA_MEMORY_BCELL_UP

OSBP MMP2 FCER2 MMP17

2.57e-04198414M4432
CoexpressionGSE12845_IGD_POS_VS_NEG_BLOOD_BCELL_UP

VTN FCER2 MMP17 AGPAT2

2.62e-04199414M3182
CoexpressionGSE24726_WT_VS_E2_2_KO_PDC_DAY6_POST_DELETION_DN

LRP1 ADAMTS10 TM9SF2 ZRANB3

2.67e-04200414M8056
CoexpressionGSE21670_TGFB_VS_IL6_TREATED_CD4_TCELL_UP

OSBP VTN FCER2 MALL

2.67e-04200414M7437
CoexpressionJI_CARCINOGENESIS_BY_KRAS_AND_STK11_DN

MMP2 WNT2

3.20e-0417412M1767
CoexpressionJI_CARCINOGENESIS_BY_KRAS_AND_STK11_DN

MMP2 WNT2

3.20e-0417412MM1225
CoexpressionGAUTAM_EYE_IRIS_CILIARY_BODY_SCHWANN_CELLS

COL5A3 HCFC2 MMP17

3.92e-0491413M43622
ToppCelldroplet-Heart-nan-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ADAMTS10 COL5A3 MMP2 MMP16 RYR2

2.08e-0819041696a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 MMP2 SGCD SGCG WNT2 RYR2

2.43e-081954164243190ad291d56694e2155954dbaa879c9d3844
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 MMP2 SGCD SGCG WNT2 RYR2

2.43e-08195416df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LRP1 COL5A3 MMP2 MMP16 SGCD RYR2

2.51e-08196416525d6c8a277364e624e7cc586275f8a891436b57
ToppCell343B-Fibroblasts-Fibroblast-G|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MMP2 SGCD SGCG WNT2 RYR2

2.74e-08199416f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell343B-Fibroblasts-Fibroblast-G-|343B / Donor, Lineage, Cell class and subclass (all cells)

LRP1 MMP2 SGCD SGCG WNT2 RYR2

2.74e-081994169c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCellP15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 FGF8 MMP2 MMP19 WNT2

5.47e-071744153c47d069bd836599a8d40eae485c23d4d3487517
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

MMP2 SGCG WNT2 RYR2 PTPRQ

5.95e-071774157617270f49cd6b7ba66db72d20560cee985012b2
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

MMP2 SGCG WNT2 RYR2 PTPRQ

5.95e-071774158220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

MMP2 SGCD SGCG WNT2 RYR2

6.29e-07179415e4224b2e9c4ae7da62cf670adf811f4112c7d060
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 VTN MMP2 ANGPTL7 SGCG

6.46e-07180415c2746092ef251e9d5910fe96461afdd0624a24c6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 VTN MMP2 ANGPTL7 SGCG

6.46e-0718041532c6a3886428d82fb4355d987c6d2645f333447b
ToppCell390C-Fibroblasts-Fibroblast-F|390C / Donor, Lineage, Cell class and subclass (all cells)

BRINP3 MMP2 ANGPTL7 WNT2 PTPRQ

7.40e-071854152c1f14f77faeee2acb388d997c5a27a7fef79be1
ToppCell390C-Fibroblasts-Fibroblast-F-|390C / Donor, Lineage, Cell class and subclass (all cells)

BRINP3 MMP2 ANGPTL7 WNT2 PTPRQ

7.40e-0718541537db8e0b1f59274227f6fc2362167eb44bd080ef
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MMP2 SGCD SGCG WNT2 RYR2

7.60e-071864155473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 FCRLB BRINP3 MMP2 MMP16

8.01e-07188415a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCell(2)_Fibroblasts-(20)_Fibro-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

LRP1 COL5A3 MMP2 MMP19 WNT2

8.01e-07188415409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 FCRLB BRINP3 MMP2 MMP16

8.01e-07188415c8530c9ff98666c64a94683261af4288cb790a7e
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 MMP2 MMP19 WNT2 RYR2

8.22e-071894152a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 MMP19 WNT2

8.44e-07190415bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 MMP19 WNT2

8.44e-07190415e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 MMP19 WNT2

8.44e-07190415ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MMP2 MMP11 MMP19 ANGPTL7

8.89e-0719241541a8326cd5bc19ad5041068501bab4c72399222e
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 MMP2 SGCD WNT2 RYR2

8.89e-071924153d0cb19f037f604253d7d728689aeaa94251e92b
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL5A3 BRINP3 MMP2 MMP16 SGCD

8.89e-07192415e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MMP2 MMP11 MMP19 ANGPTL7

8.89e-07192415f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCellMesenchymal-matrix_fibroblast_2_cell|World / Lineage, Cell type, age group and donor

COL5A3 BRINP3 MMP2 MMP16 SGCD

8.89e-07192415a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL5A3 BRINP3 MMP2 MMP16 SGCD

9.12e-071934159ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell10x5'v1-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

COL5A3 BRINP3 MMP2 SGCD WNT2

9.12e-071934153d85c28f6ebdcb15e875ad01d52d6c138fbf8525
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LRP1 MMP2 SGCD SGCG WNT2

9.35e-071944158c37bedb23285735ff3828db3889897fada8c95d
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 MMP2 SGCD WNT2 RYR2

9.35e-071944156e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCelldroplet-Heart-nan-3m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ADAMTS10 COL5A3 MMP2 MMP16

9.35e-07194415ce32e60bcea1b8baf496ce9050832bc8c77d8434
ToppCelldroplet-Heart-nan-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 ADAMTS10 COL5A3 MMP2 MMP16

9.35e-07194415a1dc157148885cc8d3685ac81a1f4e3562aeecc9
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BRINP3 MMP16 SGCD SGCG WNT2

9.35e-0719441571d3c7448b1734de54187f902f65649f9283bd4c
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MMP2 SGCD SGCG WNT2 RYR2

9.84e-07196415cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MMP2 SGCD SGCG WNT2 RYR2

9.84e-071964159737a5f006d37b549f281e1863aca558e1e4dc99
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VTN NXPH4 WNT2 GABRA1 PTPRQ

1.01e-0619741588a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCellParenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

VTN NXPH4 WNT2 GABRA1 PTPRQ

1.01e-061974152773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MMP2 SGCD SGCG WNT2 RYR2

1.01e-0619741513896ec65ccda0b928c91d41112dc01b480036b7
ToppCelltumor_Lung-Fibroblasts-Myofibroblasts|tumor_Lung / Location, Cell class and cell subclass

LRP1 MMP2 MMP11 SGCD WNT2

1.03e-0619841531f9181dab689aabe9c6182c2ef7de65ba3f0ff6
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MMP2 SGCD SGCG WNT2 RYR2

1.03e-06198415f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCellBiopsy_Control_(H.)-Mesenchymal-Myofibroblasts|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

COL5A3 MMP2 MMP11 SGCD WNT2

1.06e-061994157a227c239afdaebcac84644d9b2653a5f1a4be71
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MMP2 SGCD SGCG WNT2 RYR2

1.06e-0619941566a79732caf2f04c09b4d9832377aa01ca477677
ToppCellFibroblasts|World / lung cells shred on cell class, cell subclass, sample id

COL5A3 MMP2 SGCD WNT2 RYR2

1.06e-06199415e2b6752fcabd5249a166486ae6796f2c97c1fcaf
ToppCell(5)_Fibroblast-G|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

LRP1 MMP2 SGCD SGCG WNT2

1.06e-06199415b4a737575be9f8c65771832dd8cd25328d5dae0d
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1 COL5A3 BRINP3 MMP2 SGCD

1.09e-06200415747c61d4e0b746278ae1f45ca4cd556c6961c76a
ToppCelldistal-mesenchymal-Myofibroblast-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ANGPTL6 BRINP3 MMP2 MMP11 SGCD

1.09e-06200415069c8949b33ecfdb6da32992002d4060ff6082bc
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MMP2 MMP11 MMP16 SGCD SGCG

1.09e-0620041516a7c398626b6e82b394eb3ef013bda3a788659d
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MMP2 SGCD SGCG WNT2 RYR2

1.09e-062004158c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1 COL5A3 BRINP3 MMP2 SGCD

1.09e-06200415de1d193f773f4e2927baa6fc38d29754b015c6e6
ToppCellFrontal_cortex-Endothelial-MURAL|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ATP13A5 COL5A3 VTN SGCG

1.12e-051514147570372a315bc312ff57bb5f483375c401ae8787
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ATP13A5 COL5A3 VTN SGCG

1.12e-05151414527059e47e381b2f6d63c1abb39bc0795ee3829d
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

1.67e-05167414805129f887078340b260aa136b0ba19f2bd6ea03
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

1.67e-0516741431cf8bf2eb523f6e7e319620648ff37fc09e2601
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

1.67e-051674143acb18428d1d33ad430c2fd031b1a91baee3c01d
ToppCell-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

MMP2 SGCD SGCG WNT2

1.75e-051694148ebe9a88111c53a09c25a7b6a164a0a17880458d
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 COL5A3 MMP17 RYR2

1.79e-051704145570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellfacs-Heart-RV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 WNT2

1.79e-05170414d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCellPericytes-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

COL5A3 MMP16 NXPH4 RYR2

1.83e-05171414bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BRINP3 MMP16 SGCD RYR2

1.91e-05173414cb6389536195443633adb06e5f1b7483530773d1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MMP2 MMP17 ANGPTL7

1.96e-051744149c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MMP2 MMP17 ANGPTL7

1.96e-05174414bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A5 FCER2 RYR2 PTPRQ

2.00e-05175414887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellfacs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 WNT2

2.05e-05176414c0a084f7a8645262d61971f094689e02bf15b113
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A5 FCER2 RYR2 PTPRQ

2.05e-05176414c6484334187f64cd00cd35e77d8ae436556b4260
ToppCellfacs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 WNT2

2.05e-05176414cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|390C / Donor, Lineage, Cell class and subclass (all cells)

BRINP3 MMP2 SGCD RYR2

2.05e-05176414852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|390C / Donor, Lineage, Cell class and subclass (all cells)

BRINP3 MMP2 SGCD RYR2

2.05e-05176414d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 MMP2 MMP16 SGCD

2.14e-0517841427497dbfcf9bb4dd0bf7caa0bd78c7e85f5c18ee
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

LRP1 ADAMTS10 MMP2 MMP19

2.14e-05178414142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellfacs-Lung-EPCAM-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 MMP2 MMP16 SGCD

2.14e-05178414d348a9550db940d204706529759dc51e30506b5f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MMP2 MMP11 ANGPTL7

2.19e-0517941468ccfe66474d049a926afc21bffa231446becc69
ToppCell-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

MMP2 SGCD SGCG WNT2

2.19e-0517941410fadbaa1b6d21cbf9f354d717cc4c225619f4fd
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

2.24e-05180414935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 SGCD WNT2 RYR2

2.24e-0518041408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell5'-Airway_Nasal-Mesenchymal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

2.24e-051804143dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SGCD SGCG WNT2 RYR2

2.28e-051814149ede19228ba5c0668a9c06c915510b95585216ef
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

2.38e-051834146d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

2.38e-05183414cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

2.38e-05183414803376f5260de83c48d4f7301278d078a32b3e6e
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 VTN MMP2 MMP19

2.44e-05184414fe4d3def3da4ffdea5ae6bb059f5397efd58fef3
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-4|TCGA-Bladder / Sample_Type by Project: Shred V9

ADAMTS10 MMP2 SGCD WNT2

2.49e-05185414e1f3f0e974eb3fe1c05018beb9e124c7fb0cbe50
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A3 MMP2 MMP17 ZRANB3

2.49e-05185414ca69499ba8c39b7ed6717d05685d6f70066a77bd
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL5A3 MMP2 MMP11 SGCD

2.49e-0518541487c416d14ca6255bee39b16e7571553e36ee3069
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 ADAMTS10 MMP19 SGCD

2.54e-05186414f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BRINP3 MMP2 SGCD RYR2

2.54e-051864147def03dd856b765bd3f493288641981c4f7fd26e
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

BRINP3 MMP16 SGCD RYR2

2.59e-05187414bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellfacs-Bladder-nan-24m-Epithelial-bladder_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MMP2 ANGPTL7 WNT2

2.59e-051874142c145e9d11424939dd99012a8cedf5d998b966e9
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MMP2 MMP19 WNT2

2.65e-05188414c32d023a69b6da79687ff8fa7485e7499db57046
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 MMP2 MMP19 WNT2

2.65e-051884141cd5a4d744bd3777246958ea5eb94388a5cbad81
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-Oligodendrocyte_progenitor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 BRINP3 MMP2 MMP16

2.65e-05188414053c251d3ddbeb866f34565aefca4535517b4387
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 BRINP3 MMP2 MMP16

2.65e-051884147471c194276161422326647f09022e94f3d1640c
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 MMP19

2.71e-05189414544d95df910f1b276995624509a7e41b219baca0
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MMP2 SGCG RYR2

2.71e-051894142a5fda73d38bdc23cf47e5335ffd4e086e990245
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 WNT2

2.71e-05189414bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP16 MMP17 SGCD GABRA1

2.76e-05190414ff3dec5b45c6ea9b5319fb51a0198c6773b7be26
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 WNT2

2.76e-05190414f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 BRINP3 MMP2 MMP16

2.76e-051904149b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A3 MMP2 WNT2

2.76e-05190414c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 MMP2 SGCD WNT2

2.76e-05190414841cd55861b43578d704418b9bc0af2e8b88323a
DrugAC1L9M3B

MMP2 MMP11 MMP16 MMP17 MMP19 SGCD SGCG

1.21e-1161407CID000448562
Drugdiacerein

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 WNT2

1.53e-1163407CID000026248
Drugmalolactomycin D

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

1.74e-1132406CID006449115
DrugDA-125

MMP2 MMP11 MMP16 MMP17 MMP19

8.27e-1026405CID000114758
Drugmercuric acetate

MMP2 MMP11 MMP16 MMP17 MMP19

1.78e-0930405CID000015337
DrugAC1L1GXT

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

3.37e-0974406CID000003890
Drugperoxynitrite

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 ATP2A1 FCN2 RYR2

1.35e-08373409CID000104806
Drugtitanium

MMP25 VTN MMP2 MMP11 MMP16 MMP17 MMP19

1.73e-08170407CID000023963
DrugAC1L1DD6

MMP25 MMP2 FCER2 MMP11 MMP16 MMP17 MMP19

2.47e-08179407CID000002299
Drug4-aminophenyl

MMP2 MMP11 MMP16 MMP17 MMP19

7.77e-0862405CID000181201
Drugpirfenidone

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

1.44e-07138406CID000040632
Drugnitric oxide

MMP25 MMP2 FCER2 MMP11 MMP16 MMP17 MMP19 ATP2A1 FCN2 SGCG WNT2 RYR2

1.89e-0710754012CID000145068
DrugA0395

MMP2 MMP11 MMP16 MMP17 MMP19

2.04e-0775405CID009906466
DrugAC1NSU5S

MMP2 MMP11 MMP16 MMP17 MMP19

2.04e-0775405CID005316299
Drugenantio-PAF-C16

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 FCN2

2.05e-07244407CID000002499
Drugisoflavone

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

2.86e-07155406CID000072304
Drugcarvedilol

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

3.58e-07161406CID000002585
Drugaldosterone

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 MALL RYR2

3.76e-07397408CID000005839
Druglatanoprost acid

MMP2 MMP11 MMP16 MMP17

7.13e-0740404CID006441636
Drugacetate

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 ATP2A1 FCN2 SGCG

7.51e-07599409CID000000175
Drugquercetin

MMP25 MMP2 HCFC2 MMP11 MMP16 MMP17 MMP19 ATP2A1

1.61e-06482408CID005280343
Drugoxidized glutathione

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

2.66e-06227406CID000000975
DrugAC1L1HMM

MMP25 OSBP VTN MMP2 MMP11 MMP16 MMP17 MMP19

2.68e-06516408CID000004196
Druglosartan

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 SGCG

3.82e-06378407CID000003961
Drugquinacrine

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

3.94e-06243406CID000000237
DrugMMI270

MMP2 MMP16 MMP17

4.02e-0618403CID000446504
Drug2,2',3,5',6-pentachlorobiphenyl

WNT2 RYR2 GABRA1

5.61e-0620403ctd:C032904
Drugnoradrealine

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 SGCD RYR2

5.94e-06575408CID000000951
Drug1,10-phenanthroline

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

6.75e-06267406CID000001318
Drugdioxane

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

8.50e-06278406CID000031275
Druggluconate

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

1.02e-05287406CID000000604
DrugPro-leu-gly

MMP2 MMP16 MMP17

1.27e-0526403CID000169533
DrugIopromide [73334-07-3]; Up 200; 5uM; MCF7; HT_HG-U133A

MMP25 MMP2 MMP16 MMP19 ATP2A1

2.37e-051974056842_UP
DrugPF-01378883-00 [351320-41-7]; Down 200; 10uM; MCF7; HT_HG-U133A

NUP188 FCER2 MMP11 MMP17 MMP19

2.43e-051984056363_DN
DrugTranexamic acid [1197-18-8]; Up 200; 25.4uM; MCF7; HT_HG-U133A

NUP188 CASD1 HCFC2 NXPH4 AGPAT2

2.43e-051984056238_UP
Drugvalerate

MMP2 MMP11 MMP16 MMP17

3.07e-05102404CID000007991
Drugraloxifene

OSBP MMP2 MMP11 MMP16 MMP17 MMP19

3.17e-05351406CID000005035
Drugglutathione reduced

MMP25 MMP2 HCFC2 MMP11 MMP16 MMP17 MMP19

3.58e-05534407CID000000745
Drugmag-fura-2

FCER2 ATP2A1 RYR2

3.74e-0537403CID000123839
DrugNSC236997

STK38 MMP2 MMP11 MMP16 MMP17 MMP19 RYR2

3.79e-05539407CID000005300
Drugbenzoxazolinate

SGCD SGCG

4.49e-056402CID005281925
DrugSer-Asp-Gly-Arg-Gly

VTN MMP2

4.49e-056402CID004640574
Drugdibutyryl cyclic 3',5'-AMP

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 FCN2

4.89e-05561407CID000002460
Drugpseudococaine

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19 ATP2A1

5.40e-05570407CID000002826
Drug17alpha-estradiol

MMP25 LRP1 OSBP MMP2 MMP11 MMP16 MMP17 MMP19 WNT2 GABRA1

6.37e-0513034010CID000000450
Drugpolyethylenimine

MMP2 MMP11 MMP17 RYR2

7.45e-05128404CID000009033
DrugAC1Q5TCI

SGCD SGCG

8.37e-058402CID000000116
DrugMarimastat

MMP2 MMP16

8.37e-058402DB00786
DrugCGS 27023A

MMP2 MMP16

1.08e-049402ctd:C097658
DrugAC1L1B55

MMP25 MMP2 MMP11 MMP16 MMP17 MMP19

1.31e-04454406CID000001287
Drugbacoside A

MMP2 GABRA1

1.34e-0410402ctd:C500175
DrugThalidomide

FGF8 VTN MMP2 ZRANB3 RYR2 PTPRQ

1.76e-04479406ctd:D013792
Drugtetrahydroneopterin

MMP2 NXPH4

2.32e-0413402CID000161510
DrugPhe-glu

VTN MMP2

2.32e-0413402CID000151134
DrugDB07883

MMP2 MMP16 MMP17

3.11e-0475403CID000446476
DrugMetoprolol

MMP2 SGCD RYR2

3.36e-0477403ctd:D008790
DrugAC1MQZ6I

MMP2 MMP11 MMP16 MMP17

3.39e-04190404CID003509873
Drugpentosan polysulfate

FGF8 VTN MMP2

3.62e-0479403CID000037720
Drug(-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A

MMP25 NUP188 MALL RYR2

3.67e-041944046833_UP
DrugXylazine [7361-61-7]; Up 200; 18.2uM; HL60; HT_HG-U133A

ATP2A1 SIGLEC9 SGCD RYR2

3.75e-041954042132_UP
DrugNefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; MCF7; HT_HG-U133A

NUP188 MMP11 MMP16 SGCD

3.82e-041964044752_UP
DrugPHA-00851261E [724719-49-7]; Down 200; 1uM; PC3; HT_HG-U133A

MMP2 SGCD RYR2 AGPAT2

3.82e-041964043776_DN
DrugDehydroisoandosterone 3-acetate [853-23-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

LRP1 MMP16 SGCD RYR2

3.82e-041964046673_DN
DrugKanamycin A sulfate [25389-94-0]; Up 200; 6.8uM; PC3; HT_HG-U133A

MMP11 SGCD WNT2 RYR2

3.89e-041974044625_UP
DrugEvoxine [522-11-2]; Up 200; 11.6uM; HL60; HT_HG-U133A

LRP1 NUP188 MMP19 RYR2

3.89e-041974042186_UP
DrugTiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Down 200; 6.4uM; MCF7; HT_HG-U133A

NUP188 MMP19 MALL SGCG

3.89e-041974042259_DN
Drug(+) -Levobunolol hydrochloride [47141-41-3]; Up 200; 12.2uM; MCF7; HT_HG-U133A

NUP188 MMP11 MMP17 SGCG

3.89e-041974043355_UP
Drugmagnesium

MMP25 MMP2 FCER2 MMP11 MMP16 MMP17 MMP19 ATP2A1 RYR2

3.95e-041325409CID000000888
DrugLaudanosine (R,S) [1699-51-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A

MMP2 ATP2A1 NXPH4 WNT2

3.97e-041984042890_UP
DrugAG-013608 [351320-38-2]; Down 200; 10uM; MCF7; HT_HG-U133A

MMP25 NUP188 MMP11 MALL

3.97e-041984045904_DN
DrugU-62066 [87151-85-7]; Up 200; 1uM; PC3; HT_HG-U133A

LRP1 NUP188 MMP2 MMP16

3.97e-041984044553_UP
DrugAcacetin [480-44-4]; Up 200; 14uM; MCF7; HT_HG-U133A

FCER2 MMP19 SGCD RYR2

3.97e-041984046044_UP
DrugTinidazole [19387-91-8]; Down 200; 16.2uM; MCF7; HT_HG-U133A

OSBP MMP16 ATP2A1 NXPH4

3.97e-041984044370_DN
DrugBudesonide [51333-22-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A

MMP25 NUP188 FCER2 MMP11

3.97e-041984045431_UP
DrugRemoxipride Hydrochloride [73220-03-8]; Up 200; 9.8uM; MCF7; HT_HG-U133A

MMP25 FCER2 ATP2A1 MALL

3.97e-041984045443_UP
DrugClemizole hydrochloride [1163-36-6]; Up 200; 11uM; MCF7; HT_HG-U133A

NUP188 MMP11 SGCD SGCG

3.97e-041984044695_UP
DrugAzaguanine-8 [134-58-7]; Up 200; 26.2uM; MCF7; HT_HG-U133A

MMP25 ATP2A1 SGCD SGCG

3.97e-041984041670_UP
DrugMepenzolate bromide [76-90-4]; Up 200; 9.6uM; PC3; HT_HG-U133A

MMP25 NUP188 MMP16 ATP2A1

3.97e-041984043748_UP
DrugMeticrane [1084-65-7]; Up 200; 14.6uM; MCF7; HT_HG-U133A

MMP17 SGCG NXPH4 RYR2

3.97e-041984041671_UP
Drugrofecoxib; Up 200; 10uM; MCF7; HG-U133A

NUP188 MMP11 MMP17 MMP19

3.97e-04198404256_UP
DrugGlutethimide, para-amino [125-84-8]; Up 200; 17.2uM; MCF7; HT_HG-U133A

OSBP CASD1 MMP2 MMP16

3.97e-041984047421_UP
Drugthiirane

MMP2 SGCG

4.03e-0417402CID000009865
Drugbiopterin

SGCD SGCG NXPH4

4.04e-0482403CID000002380
DrugEtofylline [519-37-9]; Up 200; 17.8uM; PC3; HT_HG-U133A

MMP25 MMP11 MMP19 RYR2

4.05e-041994045048_UP
DrugCGX 0596987; Down 200; 20uM; MCF7; HT_HG-U133A

FCER2 MMP16 MMP19 MALL

4.05e-041994046364_DN
DrugHomosalate [118-56-9]; Down 200; 15.2uM; MCF7; HT_HG-U133A

MMP2 MMP17 MALL SGCG

4.05e-041994043879_DN
Drug0317956-0000 [391210-11-0]; Up 200; 10uM; PC3; HT_HG-U133A

MMP16 MMP17 SGCD RYR2

4.05e-041994043774_UP
DrugFluvastatin sodium salt [93957-55-2]; Up 200; 9.2uM; HL60; HT_HG-U133A

SIGLEC9 SGCD NXPH4 GABRA1

4.05e-041994043032_UP
Drugvaldecoxib; Up 200; 10uM; MCF7; HT_HG-U133A

MMP11 MMP16 MALL FCN2

4.12e-042004046403_UP
DrugDeferoxamine mesylate [138-14-7]; Up 200; 6uM; MCF7; HT_HG-U133A

MMP25 MMP11 SGCD WNT2

4.12e-042004043936_UP
DrugSpectinomycin dihydrochloride [21736-83-4]; Up 200; 9.8uM; HL60; HT_HG-U133A

LRP1 MMP16 MMP19 SIGLEC9

4.12e-042004042987_UP
Drugt5mvntj c2mvmr[wln]

VTN SGCD

5.05e-0419402CID000115176
DrugAC1L380G

ATP2A1 RYR2

5.05e-0419402CID000084698
Diseasedilated cardiomyopathy 1L (implicated_via_orthology)

SGCD SGCG

5.10e-063392DOID:0110436 (implicated_via_orthology)
Diseasedipeptidyl peptidase 2 measurement

VTN AGPAT2

3.56e-057392EFO_0020326
Diseasecardiomyopathy (implicated_via_orthology)

LRP1 SGCD SGCG

1.15e-0471393DOID:0050700 (implicated_via_orthology)
Diseasemannan-binding lectin serine protease 1 measurement

VTN FCN2

1.77e-0415392EFO_0008223
Diseasemuscular dystrophy (implicated_via_orthology)

SGCD SGCG

3.52e-0421392DOID:9884 (implicated_via_orthology)
DiseaseLimb-girdle muscular dystrophy

SGCD SGCG

5.42e-0426392cv:C0686353
DiseaseMuscular Dystrophies, Limb-Girdle

SGCD SGCG

8.23e-0432392C0686353
Diseasemetastasis measurement, disease progression measurement

BRINP3 SGCD

9.30e-0434392EFO_0007675, EFO_0008336
Diseaseheart disease (implicated_via_orthology)

ATP2A1 RYR2

1.16e-0338392DOID:114 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
FSTRYKIYREFGRWK

BRINP3

71

Q76B58
KREFGFYSKSQYRTW

ATP13A5

1146

Q4VNC0
YGYFAGLCRRLQKFW

ARMH2

16

H3BNL8
GVFNEYRTIWFKSYR

COQ3

51

Q9NZJ6
GSWFRGAIYYFKIAV

ATP2A1

286

O14983
FRGKFYKWKTYRGGG

ADAMTS10

621

Q9H324
RAKKIFGWGDFYFRV

NXPH4

101

O95158
YIFAGDKFWRYNEVK

MMP2

581

P08253
KCVVRYRGKTYSGYW

C9orf64

86

Q5T6V5
LVSFYRDWKQYKQGF

ANGPTL7

181

O43827
GKTYLVRGRQYWRYD

MMP25

426

Q9NPA2
RLYFWSGRDGYKKAL

HCFC2

326

Q9Y5Z7
SYLFGFYKRFESWRV

MALL

76

Q13021
VFWYKRRVQGAKGFQ

LRP1

4441

Q07954
RGKTYAFKGDYVWTV

MMP19

301

Q99542
QDGRVYFFKGKVYWR

MMP19

436

Q99542
KWINFQRKCYYFGKG

FCER2

166

P06734
YFTKRGYAWDGKSVV

GABRA1

336

P14867
YIKGYQRRWFVLSNG

OSBP

101

P22059
ETVYGLKKFRWYRFQ

PTPRQ

1541

Q9UMZ3
NAKYEGWYMAFTRKG

FGF8

161

P55075
FSYFWIKGDFGIYRV

CASD1

476

Q96PB1
YRDWATYKQGFGSRL

FCN2

156

Q15485
VYWAEFRGGAYSLRK

ANGPTL6

446

Q8NI99
FYKYSRAVRRFDWGA

FCRLB

236

Q6BAA4
FQQRGKKAFEWYGTY

METTL13

21

Q8N6R0
EKTYAVKAGRWYFEF

RYR2

1091

Q92736
GGWYSTFRRGKKFSY

COL5A3

1606

P25940
SIIGWFVRSFKYFYG

AGPAT2

61

O15120
EKNKIYFFRGRDYWR

MMP11

396

P24347
RYFGGMVWYFVNNKK

MRPS22

266

P82650
KDWVFINYTYKRFEG

STK38

436

Q15208
MRVRKGFEDWYSGYF

SLC16A14

291

Q7RTX9
QIRGEAFFFKGKYFW

MMP17

341

Q9ULZ9
AFFFKGKYFWRLTRD

MMP17

346

Q9ULZ9
RYFFRMEKGSIKWNY

SIGLEC9

116

Q9Y336
QYVYKIGIYGWRKRC

SGCG

21

Q13326
DFRKTGDYLWRKYNG

WNT2

226

P09544
EDVGKTYFFKGDRYW

MMP16

446

P51512
VYKVGIYGWRKRCLY

SGCD

21

Q92629
FSIEKRFAYWSGYVK

NUP188

1066

Q5SRE5
YVAARFYKSFGGEKW

TM9SF2

416

Q99805
QGKTYLFKGSQYWRF

VTN

216

P04004
SGRERVYFFKGKQYW

VTN

266

P04004
FPQKFGRWTDYAKRY

ZRANB3

206

Q5FWF4