Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium-dependent protein serine/threonine kinase activity	MKNK2 PRKCG MKNK1	7.85e-06	10	82	3	GO:0009931
GeneOntologyMolecularFunction	potassium channel inhibitor activity	WNK1 WNK4 WNK3	1.08e-05	11	82	3	GO:0019870
GeneOntologyMolecularFunction	potassium channel regulator activity	FLNA WNK1 WNK4 WNK3	8.84e-05	57	82	4	GO:0015459
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	BMPR2 MKNK2 FER PRKCG PIPSL WNK1 WNK4 WNK3 MKNK1 PTK7	6.37e-04	709	82	10	GO:0016773
GeneOntologyMolecularFunction	molecular condensate scaffold activity	LAT WNK1 WNK3	6.83e-04	42	82	3	GO:0140693
GeneOntologyMolecularFunction	protein kinase activity	BMPR2 MKNK2 FER PRKCG WNK1 WNK4 WNK3 MKNK1 PTK7	7.83e-04	600	82	9	GO:0004672
GeneOntologyMolecularFunction	ion channel inhibitor activity	WNK1 WNK4 WNK3	1.01e-03	48	82	3	GO:0008200
GeneOntologyMolecularFunction	kinase activity	BMPR2 MKNK2 FER PRKCG PIPSL WNK1 WNK4 WNK3 MKNK1 PTK7	1.13e-03	764	82	10	GO:0016301
GeneOntologyMolecularFunction	channel inhibitor activity	WNK1 WNK4 WNK3	1.14e-03	50	82	3	GO:0016248
GeneOntologyMolecularFunction	transporter inhibitor activity	WNK1 WNK4 WNK3	1.21e-03	51	82	3	GO:0141110
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	MAGI2 PTPN11 LAT	1.42e-03	54	82	3	GO:0030159
GeneOntologyMolecularFunction	D1 dopamine receptor binding	PTPN11 GNAS	1.47e-03	14	82	2	GO:0031748
GeneOntologyBiologicalProcess	negative regulation of pancreatic juice secretion	WNK1 WNK4 WNK3	6.02e-07	5	82	3	GO:0090188
GeneOntologyBiologicalProcess	negative regulation of sodium ion transport	HECW1 WNK1 WNK4 WNK3	1.61e-06	22	82	4	GO:0010766
GeneOntologyBiologicalProcess	positive regulation of potassium ion import across plasma membrane	WNK1 WNK4 WNK3	2.10e-06	7	82	3	GO:1903288
GeneOntologyBiologicalProcess	regulation of potassium ion import	WNK1 WNK4 WNK3	5.00e-06	9	82	3	GO:1903286
GeneOntologyBiologicalProcess	regulation of pancreatic juice secretion	WNK1 WNK4 WNK3	5.00e-06	9	82	3	GO:0090186
GeneOntologyBiologicalProcess	pancreatic juice secretion	WNK1 WNK4 WNK3	2.14e-05	14	82	3	GO:0030157
GeneOntologyBiologicalProcess	positive regulation of potassium ion transmembrane transport	FLNA WNK1 WNK4 WNK3	2.31e-05	42	82	4	GO:1901381
GeneOntologyBiologicalProcess	regulation of sodium ion transport	HECW1 GNAS WNK1 WNK4 WNK3	5.16e-05	101	82	5	GO:0002028
GeneOntologyBiologicalProcess	positive regulation of potassium ion transport	FLNA WNK1 WNK4 WNK3	6.31e-05	54	82	4	GO:0043268
GeneOntologyBiologicalProcess	negative regulation of digestive system process	WNK1 WNK4 WNK3	6.58e-05	20	82	3	GO:0060457
GeneOntologyBiologicalProcess	positive regulation of phosphate metabolic process	RGMA MAGI2 BMPR2 PTPN11 VTN PPP2R5D LAT GAPDHS GNAS WNK4 WNK3 HSP90AA1	1.77e-04	879	82	12	GO:0045937
GeneOntologyBiologicalProcess	positive regulation of phosphorus metabolic process	RGMA MAGI2 BMPR2 PTPN11 VTN PPP2R5D LAT GAPDHS GNAS WNK4 WNK3 HSP90AA1	1.77e-04	879	82	12	GO:0010562
GeneOntologyBiologicalProcess	regulation of protein modification process	RGMA MAGI2 BMPR2 PTPN11 VTN PPP2R5D LAT PTPRO FER PRKCG GNAS WNK1 NXN WNK4 WNK3 HSP90AA1	2.19e-04	1488	82	16	GO:0031399
GeneOntologyBiologicalProcess	negative regulation of protein localization to plasma membrane	WNK1 WNK4 WNK3	2.51e-04	31	82	3	GO:1903077
GeneOntologyBiologicalProcess	glomerular filtration	PTPRO TMEM63C TBC1D8B	3.03e-04	33	82	3	GO:0003094
GeneOntologyBiologicalProcess	negative regulation of protein localization to cell periphery	WNK1 WNK4 WNK3	3.03e-04	33	82	3	GO:1904376
GeneOntologyBiologicalProcess	regulation of blood pressure	BMPR2 ERAP2 PTPRO GNAS WNK1 WNK4	3.65e-04	237	82	6	GO:0008217
GeneOntologyBiologicalProcess	renal filtration	PTPRO TMEM63C TBC1D8B	3.93e-04	36	82	3	GO:0097205
GeneOntologyCellularComponent	Golgi-associated vesicle	ACTR1A SCFD1 GNAS RASSF9 DOP1A RHO	4.63e-06	114	79	6	GO:0005798
GeneOntologyCellularComponent	cell-cell junction	MAGI2 FLNA BMPR2 LAT FER PRKCG WNK4 WNK3 RHO PTK7	7.54e-05	591	79	10	GO:0005911
GeneOntologyCellularComponent	dendrite	MAGI2 CNNM4 FLNA BMPR2 KLHL1 SACS PTPRO FAT3 PRKCG GNAS HSP90AA1 GABRA5	8.62e-05	858	79	12	GO:0030425
GeneOntologyCellularComponent	dendritic tree	MAGI2 CNNM4 FLNA BMPR2 KLHL1 SACS PTPRO FAT3 PRKCG GNAS HSP90AA1 GABRA5	8.82e-05	860	79	12	GO:0097447
GeneOntologyCellularComponent	cilium	CEP104 MAGI2 RPGRIP1 KIF9 C2CD3 GAPDHS CTSH HYDIN HSP90AA1 RHO CC2D2B	5.41e-04	898	79	11	GO:0005929
GeneOntologyCellularComponent	somatodendritic compartment	MAGI2 CNNM4 FLNA BMPR2 KLHL1 SACS PTPRO FAT3 PRKCG GNAS HSP90AA1 PTK7 GABRA5	6.55e-04	1228	79	13	GO:0036477
Domain	Kinase_OSR1/WNK_CCT	WNK1 WNK4 WNK3	1.44e-06	6	79	3	IPR024678
Domain	OSR1_C	WNK1 WNK4 WNK3	1.44e-06	6	79	3	PF12202
Domain	Prot_kinase_dom	BMPR2 MKNK2 FER PRKCG WNK1 WNK4 WNK3 MKNK1 PTK7	2.18e-04	489	79	9	IPR000719
Domain	PROTEIN_KINASE_DOM	BMPR2 MKNK2 FER PRKCG WNK1 WNK4 WNK3 MKNK1 PTK7	2.31e-04	493	79	9	PS50011
Domain	BTB	KLHL6 KLHL1 RCBTB1 RCBTB2 SLX4	2.34e-04	131	79	5	PF00651
Domain	Kinase-like_dom	BMPR2 MKNK2 FER PRKCG WNK1 WNK4 WNK3 MKNK1 PTK7	4.62e-04	542	79	9	IPR011009
Domain	BTB	KLHL6 KLHL1 RCBTB1 RCBTB2 SLX4	5.86e-04	160	79	5	PS50097
Domain	PROTEIN_KINASE_ATP	BMPR2 MKNK2 FER PRKCG WNK1 WNK4 WNK3 MKNK1	7.10e-04	459	79	8	PS00107
Domain	DUF4939	RTL8B RTL8A	7.78e-04	10	79	2	PF16297
Domain	DUF4939	RTL8B RTL8A	7.78e-04	10	79	2	IPR032549
Domain	Ser/Thr_kinase_AS	BMPR2 MKNK2 PRKCG WNK1 WNK4 WNK3 MKNK1	7.83e-04	357	79	7	IPR008271
Domain	PROTEIN_KINASE_ST	BMPR2 MKNK2 PRKCG WNK1 WNK4 WNK3 MKNK1	8.49e-04	362	79	7	PS00108
Domain	LDOC1-rel	RTL8B RTL8A	9.48e-04	11	79	2	IPR032567
Domain	BTB	KLHL6 KLHL1 RCBTB1 RCBTB2 SLX4	9.96e-04	180	79	5	SM00225
Domain	BTB/POZ_dom	KLHL6 KLHL1 RCBTB1 RCBTB2 SLX4	1.13e-03	185	79	5	IPR000210
Domain	Pkinase	BMPR2 MKNK2 PRKCG WNK1 WNK4 WNK3 MKNK1	1.14e-03	381	79	7	PF00069
Domain	SKP1/BTB/POZ	KLHL6 KLHL1 RCBTB1 RCBTB2 SLX4	1.24e-03	189	79	5	IPR011333
Domain	C2	RPGRIP1 C2CD3 HECW1 PRKCG	2.31e-03	131	79	4	PF00168
Domain	C2	RPGRIP1 C2CD3 HECW1 PRKCG	2.72e-03	137	79	4	SM00239
Domain	C2	RPGRIP1 C2CD3 HECW1 PRKCG	3.10e-03	142	79	4	PS50004
Domain	RCC1	RCBTB1 RCBTB2	3.19e-03	20	79	2	PF00415
Domain	-	SACS HSP90AA1	3.19e-03	20	79	2	3.30.565.10
Domain	RCC1_1	RCBTB1 RCBTB2	3.52e-03	21	79	2	PS00625
Domain	RCC1_2	RCBTB1 RCBTB2	3.52e-03	21	79	2	PS00626
Domain	RCC1_3	RCBTB1 RCBTB2	3.52e-03	21	79	2	PS50012
Domain	HATPase_C	SACS HSP90AA1	3.52e-03	21	79	2	IPR003594
Domain	-	RPGRIP1 C2CD3 HECW1 PRKCG	3.59e-03	148	79	4	2.60.40.150
Domain	Reg_chr_condens	RCBTB1 RCBTB2	3.86e-03	22	79	2	IPR000408
Domain	-	RCBTB1 RCBTB2	3.86e-03	22	79	2	2.130.10.30
Domain	S_TKc	MKNK2 PRKCG WNK1 WNK4 WNK3 MKNK1	4.14e-03	359	79	6	SM00220
Domain	RCC1/BLIP-II	RCBTB1 RCBTB2	4.22e-03	23	79	2	IPR009091
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK1 WNK4 WNK3	5.63e-08	4	85	3	34384519
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK1 WNK4 WNK3	5.63e-08	4	85	3	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK1 WNK4 WNK3	5.63e-08	4	85	3	11498583
Pubmed	SLC26A9 is a Cl(-) channel regulated by the WNK kinases.	WNK1 WNK4 WNK3	5.63e-08	4	85	3	17673510
Pubmed	Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.	WNK1 WNK4 WNK3	1.40e-07	5	85	3	24641320
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	KLHL6 KLHL1 RCBTB1 FER PRKCG RCBTB2 ASB4 WNK4 HSP90AA1	3.35e-07	372	85	9	22939624
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK1 WNK4 WNK3	4.90e-07	7	85	3	20525693
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK1 WNK4 WNK3	7.82e-07	8	85	3	23838290
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	WNK1 WNK4 WNK3	7.82e-07	8	85	3	23387299
Pubmed	IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.	WNK1 WNK4 WNK3	7.82e-07	8	85	3	21317537
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	TRIM42 SACS TMEM132D WNK1 HYDIN	1.61e-06	80	85	5	19389623
Pubmed	Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1.	RPGRIP1 TUBG2 RHO	1.67e-06	10	85	3	20592197
Pubmed	The DNA sequence and analysis of human chromosome 13.	KLHL1 BRCA2 SACS RCBTB1 RCBTB2 CCDC168	3.97e-06	170	85	6	15057823
Pubmed	New COL6A6 variant detected by whole-exome sequencing is linked to break points in intron 4 and 3'-UTR, deleting exon 5 of RHO, and causing adRP.	COL6A6 RHO	5.90e-06	2	85	2	26321861
Pubmed	Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.	MKNK2 MKNK1	5.90e-06	2	85	2	16162500
Pubmed	HSP90 is crucial for regulation of LAT expression in activated T cells.	LAT HSP90AA1	5.90e-06	2	85	2	21251717
Pubmed	Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa.	KIF9 HYDIN	5.90e-06	2	85	2	32072696
Pubmed	Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response.	WNK1 WNK4	5.90e-06	2	85	2	21704025
Pubmed	WNK kinases regulate thiazide-sensitive Na-Cl cotransport.	WNK1 WNK4	5.90e-06	2	85	2	12671053
Pubmed	WNKs are potassium-sensitive kinases.	WNK4 WNK3	5.90e-06	2	85	2	33439774
Pubmed	Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.	MKNK2 MKNK1	5.90e-06	2	85	2	28570642
Pubmed	Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.	MKNK2 MKNK1	5.90e-06	2	85	2	11463832
Pubmed	Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity.	MKNK2 MKNK1	5.90e-06	2	85	2	32712434
Pubmed	Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.	WNK1 WNK4	5.90e-06	2	85	2	22294159
Pubmed	Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene.	HSP90AA1 HSP90AA2P	5.90e-06	2	85	2	2591742
Pubmed	Expression of CLLD7 and CHC1L Proteins in Oral Epithelial Dysplasia in a Group of Thai Patients.	RCBTB1 RCBTB2	5.90e-06	2	85	2	38679985
Pubmed	Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.	WNK1 WNK4	5.90e-06	2	85	2	16899520
Pubmed	MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways.	MKNK2 MKNK1	5.90e-06	2	85	2	27087055
Pubmed	Regulation of Na+-K+-Cl- cotransporter type 2 by the with no lysine kinase-dependent signaling pathway.	WNK1 WNK3	5.90e-06	2	85	2	30917032
Pubmed	WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.	WNK4 WNK3	5.90e-06	2	85	2	18701621
Pubmed	Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis.	MKNK2 MKNK1	5.90e-06	2	85	2	17903173
Pubmed	WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.	WNK1 WNK4	5.90e-06	2	85	2	25113964
Pubmed	WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.	WNK1 WNK4	5.90e-06	2	85	2	16820787
Pubmed	The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation.	PRKCG HSP90AA1	5.90e-06	2	85	2	24117238
Pubmed	Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC.	WNK1 WNK4	5.90e-06	2	85	2	29846116
Pubmed	MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.	MKNK2 MKNK1	5.90e-06	2	85	2	36764601
Pubmed	Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion.	MKNK2 MKNK1	1.77e-05	3	85	2	27618366
Pubmed	Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E.	MKNK2 MKNK1	1.77e-05	3	85	2	29941989
Pubmed	Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.	MKNK2 MKNK1	1.77e-05	3	85	2	22544393
Pubmed	WNK kinases influence TRPV4 channel function and localization.	WNK1 WNK4	1.77e-05	3	85	2	16403833
Pubmed	The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.	MKNK2 MKNK1	1.77e-05	3	85	2	28674170
Pubmed	A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916).	RTL8B RTL8A	1.77e-05	3	85	2	9403077
Pubmed	The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.	WNK4 WNK3	1.77e-05	3	85	2	17975670
Pubmed	Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4.	WNK1 WNK4	1.77e-05	3	85	2	29459793
Pubmed	The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis.	HSP90AA1 HSP90AA2P	1.77e-05	3	85	2	20937816
Pubmed	Circadian activities of the brain MNK-eIF4E signalling axis contribute to diurnal rhythms of some cognitive functions.	MKNK2 MKNK1	1.77e-05	3	85	2	35481869
Pubmed	Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.	MKNK2 MKNK1	1.77e-05	3	85	2	26668315
Pubmed	Interaction with BRCA2 suggests a role for filamin-1 (hsFLNa) in DNA damage response.	FLNA BRCA2	1.77e-05	3	85	2	11602572
Pubmed	Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness.	HSP90AA1 HSP90AA2P	1.77e-05	3	85	2	15146192
Pubmed	Roles of mitogen-activated protein kinase signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation.	MKNK2 MKNK1	1.77e-05	3	85	2	17689282
Pubmed	Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.	WNK1 WNK4	1.77e-05	3	85	2	24821705
Pubmed	Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.	MKNK2 MKNK1	1.77e-05	3	85	2	21149447
Pubmed	Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.	WNK1 WNK4	1.77e-05	3	85	2	29667910
Pubmed	Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells.	EML4 HSP90AA1	1.77e-05	3	85	2	24952482
Pubmed	BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1.	MKNK2 MKNK1	1.77e-05	3	85	2	25609615
Pubmed	Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development.	MKNK2 MKNK1	1.77e-05	3	85	2	15254222
Pubmed	Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment.	C2CD3 CC2D2B	1.77e-05	3	85	2	22983010
Pubmed	Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.	WNK1 WNK4	1.77e-05	3	85	2	16788137
Pubmed	Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses.	MKNK2 MKNK1	1.77e-05	3	85	2	19574459
Pubmed	Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.	MKNK2 MKNK1	1.77e-05	3	85	2	20679220
Pubmed	Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.	MKNK2 MKNK1	1.77e-05	3	85	2	25527453
Pubmed	CDK7/GRP78 signaling axis contributes to tumor growth and metastasis in osteosarcoma.	FLNA BMPR2 ANKRD11 PSMD4 GAPDHS GNAS HSP90AA1 HSP90AA2P	1.97e-05	468	85	8	36042349
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	KLHL6 KLHL1 HECW1 ASB4 SLX4	2.32e-05	138	85	5	28786561
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CNNM4 HECW1 AARS2 SACS WNK1 REXO1L1P SLX4 DOP1A	2.85e-05	493	85	8	15368895
Pubmed	Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.	WNK1 WNK4	3.53e-05	4	85	2	23576762
Pubmed	The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha.	HSP90AA1 HSP90AA2P	3.53e-05	4	85	2	19234166
Pubmed	Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors.	MKNK2 MKNK1	3.53e-05	4	85	2	23814052
Pubmed	Structural insights into the recognition of substrates and activators by the OSR1 kinase.	WNK1 WNK4	3.53e-05	4	85	2	17721439
Pubmed	Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14.	HSP90AA1 HSP90AA2P	3.53e-05	4	85	2	1740332
Pubmed	MNK2 inhibits eIF4G activation through a pathway involving serine-arginine-rich protein kinase in skeletal muscle.	MKNK2 MKNK1	3.53e-05	4	85	2	22337810
Pubmed	MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.	MKNK2 MKNK1	3.53e-05	4	85	2	25403230
Pubmed	GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.	PTPN11 GAREM1	3.53e-05	4	85	2	19509291
Pubmed	WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.	WNK1 WNK4	3.53e-05	4	85	2	16832045
Pubmed	Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase.	HSP90AA1 HSP90AA2P	3.53e-05	4	85	2	23589305
Pubmed	Pseudohypoaldosteronism Type II	WNK1 WNK4	3.53e-05	4	85	2	22073419
Pubmed	Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2.	WNK1 WNK4	3.53e-05	4	85	2	29392534
Pubmed	Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a).	MKNK2 MKNK1	3.53e-05	4	85	2	23831578
Pubmed	A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.	PTPN11 GAREM1	3.53e-05	4	85	2	24003223
Pubmed	Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.	PTPN11 LAT	3.53e-05	4	85	2	15477348
Pubmed	Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.	MKNK2 MKNK1	3.53e-05	4	85	2	26147685
Pubmed	eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.	MKNK2 MKNK1	3.53e-05	4	85	2	20679199
Pubmed	BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis.	FLNA BRCA2	3.53e-05	4	85	2	22771033
Pubmed	Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.	PSMD4 PIPSL HSP90AA1 HSP90AA2P	4.13e-05	78	85	4	27114451
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	ACTR1A FLNA PSMD4 EIF3H PIPSL WNK1 WNK4 HSP90AA1 DOP1A HSP90AA2P	4.19e-05	847	85	10	35235311
Pubmed	Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.	RGMA BMPR2	5.87e-05	5	85	2	17472960
Pubmed	Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis.	MKNK2 MKNK1	5.87e-05	5	85	2	23269249
Pubmed	Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.	WNK1 WNK4	5.87e-05	5	85	2	19008908
Pubmed	The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.	MKNK2 MKNK1	5.87e-05	5	85	2	11154262
Pubmed	Phosphorylation of vitronectin on Ser362 by protein kinase C attenuates its cleavage by plasmin.	VTN PRKCG	5.87e-05	5	85	2	9030777
Pubmed	Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.	LAT SKAP2	5.87e-05	5	85	2	10942756
Pubmed	MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.	MKNK2 MKNK1	5.87e-05	5	85	2	33564073
Pubmed	WNK kinases sense molecular crowding and rescue cell volume via phase separation.	WNK1 WNK3	5.87e-05	5	85	2	36318922
Pubmed	The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.	MKNK2 MKNK1	5.87e-05	5	85	2	25588502
Pubmed	Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.	WNK1 WNK4	5.87e-05	5	85	2	34315884
Pubmed	WNK regulates Wnt signalling and β-Catenin levels by interfering with the interaction between β-Catenin and GID.	WNK1 WNK4	5.87e-05	5	85	2	33184430
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	ACTR1A FLNA PSMD4 SCFD1 EIF3H NCLN HSP90AA1	6.53e-05	408	85	7	33766124
Pubmed	Specific protein kinase C isoforms are required for rod photoreceptor differentiation.	PRKCG RHO	8.80e-05	6	85	2	22171059
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	RTL8B RTL8A	8.80e-05	6	85	2	35247097
Pubmed	Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation.	PTPN11 FER	8.80e-05	6	85	2	16731527
Pubmed	Mouse models of human ocular disease for translational research.	RPGRIP1 RHO	8.80e-05	6	85	2	28859131
Interaction	RCBTB2 interactions	TMEM132D RCBTB1 RCBTB2 WNK1 HSP90AA1	2.34e-06	52	83	5	int:RCBTB2
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	TRIM42 SACS TMEM132D FER WNK1 HYDIN	1.29e-05	181	52	6	694
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL6 KLHL1 RCBTB1 RCBTB2 SLX4	4.08e-05	134	52	5	861
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RPGRIP1 C2CD3 HECW1	1.50e-04	36	52	3	823
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	TRIM42 WNK1 CTSH	4.24e-04	51	52	3	870
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	MKNK2 MKNK1	4.39e-04	11	52	2	1156
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	BRCA2 SLX4	1.49e-03	20	52	2	548
GeneFamily	Kelch like\|BTB domain containing	KLHL6 KLHL1	6.49e-03	42	52	2	617
Coexpression	IWANAGA_CARCINOGENESIS_BY_KRAS_DN	RPGRIP1 FLNA BMPR2 RCBTB2 TBC1D8B SKAP2 REXO1L1P	2.90e-07	135	85	7	MM753
Coexpression	IWANAGA_CARCINOGENESIS_BY_KRAS_DN	RPGRIP1 FLNA BMPR2 RCBTB2 TBC1D8B SKAP2	3.51e-06	126	85	6	M9362
Coexpression	HEVNER_CORTEX_ROSTRAL_CORTICAL_PLATE	BMPR2 PTPRO FAT3 GABRA5	1.05e-05	42	85	4	MM446
Drug	AC1L9ICX	PTPRO HSP90AA1 HSP90AA2P	7.82e-06	11	84	3	CID000445664
Drug	2qfo	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID000600769
Drug	3-amino-5-chlorobenzoic acid	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID010986726
Drug	3eko	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID011160307
Drug	monocillin III	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID006478910
Drug	pochonin A	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID006478909
Drug	1uyi	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID005289232
Drug	PU-H71	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID009549213
Drug	NSC683666	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID005469153
Drug	H 64	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID006914564
Drug	SureCN4151355	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID015942101
Drug	1uyc	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID000448969
Drug	PU-9	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID000448971
Drug	P u 0	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID000448974
Drug	2qf6	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID013373715
Drug	CHEBI:42139	HSP90AA1 HSP90AA2P	1.35e-05	2	84	2	CID011562562
Drug	AC1L85F0	VTN HSP90AA1 HSP90AA2P	1.35e-05	13	84	3	CID000372766
Drug	CMV423	TMEM132D HSP90AA1 HSP90AA2P	1.35e-05	13	84	3	CID000489128
Drug	FLT3 inhibitor	PTPN11 HSP90AA1 HSP90AA2P	1.71e-05	14	84	3	CID001048845
Drug	pochonin D	HSP90AA1 HSP90AA2P	4.03e-05	3	84	2	CID006478913
Drug	azaquinone	HSP90AA1 HSP90AA2P	4.03e-05	3	84	2	CID000099132
Drug	d 1 v	HSP90AA1 HSP90AA2P	4.03e-05	3	84	2	CID000683940
Drug	HM-9	HSP90AA1 HSP90AA2P	4.03e-05	3	84	2	CID000433437
Drug	Glyoxylspermidine	HSP90AA1 HSP90AA2P	4.03e-05	3	84	2	CID000133564
Drug	AC1MD0RC	HSP90AA1 HSP90AA2P	4.03e-05	3	84	2	CID002829073
Drug	PKR inhibitor	PTPN11 TMEM132D HSP90AA1 HSP90AA2P	4.08e-05	52	84	4	CID006490494
Drug	CL-387,785	EML4 HSP90AA1 HSP90AA2P	5.28e-05	20	84	3	CID000002776
Drug	uranyl chloride	HSP90AA1 HSP90AA2P	8.03e-05	4	84	2	CID000082259
Drug	methoxyhydroquinone	HSP90AA1 HSP90AA2P	8.03e-05	4	84	2	CID000069988
Drug	11p110	HSP90AA1 HSP90AA2P	8.03e-05	4	84	2	CID002382787
Drug	NSC290205	TMEM132D GNAS	8.03e-05	4	84	2	CID000359501
Drug	Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; PC3; HT_HG-U133A	BMPR2 ERAP2 EML4 FER RCBTB2 WNK1	8.77e-05	196	84	6	2108_DN
Drug	1uy7	HSP90AA1 HSP90AA2P	1.34e-04	5	84	2	CID005289227
Drug	1uyd	HSP90AA1 HSP90AA2P	1.34e-04	5	84	2	CID000448970
Drug	Org 31806	HSP90AA1 HSP90AA2P	1.34e-04	5	84	2	CID000164147
Drug	CRT0044876	HSP90AA1 HSP90AA2P	1.34e-04	5	84	2	CID000081409
Drug	HCV-796	HSP90AA1 HSP90AA2P	1.34e-04	5	84	2	CID011561383
Drug	chaetochromin	HSP90AA1 HSP90AA2P	1.34e-04	5	84	2	CID000053277
Drug	1,1-diphenyl-2-propyn-1-ol	HSP90AA1 HSP90AA2P	1.34e-04	5	84	2	CID000092976
Drug	SC-10	PRKCG HSP90AA1 HSP90AA2P	1.48e-04	28	84	3	CID000005175
Drug	TM02	HSP90AA1 RHO HSP90AA2P	1.48e-04	28	84	3	CID000012902
Drug	AC1O5WLA	PTPN11 HSP90AA1 HSP90AA2P	1.83e-04	30	84	3	CID006442113
Drug	Hantzsch ester	HSP90AA1 HSP90AA2P	2.00e-04	6	84	2	CID000070849
Drug	3-aminocoumarin	HSP90AA1 HSP90AA2P	2.00e-04	6	84	2	CID000074217
Drug	Pu x	HSP90AA1 HSP90AA2P	2.00e-04	6	84	2	CID000448976
Drug	AC1L8SKE	FLNA HSP90AA1 HSP90AA2P	2.02e-04	31	84	3	CID000386852
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK1 WNK4 WNK3	3.96e-07	6	81	3	DOID:4479 (implicated_via_orthology)
Disease	Pseudohypoaldosteronism, Type I	GNAS WNK1 WNK4	2.36e-06	10	81	3	C0268436
Disease	Pseudohypoaldosteronism	GNAS WNK1 WNK4	2.36e-06	10	81	3	C0033805
Disease	Hyperpotassemia and Hypertension, Familial	GNAS WNK1 WNK4	2.36e-06	10	81	3	C2713447
Disease	Pseudohypoaldosteronism, Type I, Autosomal Recessive	GNAS WNK1 WNK4	2.36e-06	10	81	3	C1449843
Disease	Pseudohypoaldosteronism, Type II	GNAS WNK1 WNK4	2.36e-06	10	81	3	C1449844
Disease	Pseudohypoaldosteronism, Type I, Autosomal Dominant	GNAS WNK1 WNK4	2.36e-06	10	81	3	C1449842
Disease	Pseudohypoaldosteronism type 2A	WNK1 WNK4	4.45e-05	4	81	2	cv:C1840389
Disease	Pseudohypoaldosteronism, type 2	WNK1 WNK4	4.45e-05	4	81	2	cv:C1449844
Disease	Neurodevelopmental Disorders	PTPN11 PPP2R5D ANKRD11 PTK7	1.28e-04	93	81	4	C1535926
Disease	pseudohypoaldosteronism (is_implicated_in)	WNK1 WNK4	2.06e-04	8	81	2	DOID:4479 (is_implicated_in)
Disease	Fanconi anemia	BRCA2 SLX4	6.63e-04	14	81	2	cv:C0015625
Disease	superior parietal cortex volume measurement	C3P1 GALNT1	7.64e-04	15	81	2	EFO_0010330
Disease	MYELODYSPLASTIC SYNDROME	PTPN11 BRCA2 SLX4	8.41e-04	67	81	3	C3463824
Disease	idiopathic scoliosis (implicated_via_orthology)	PTPN11 PTK7	8.71e-04	16	81	2	DOID:0060250 (implicated_via_orthology)
Disease	Bone marrow hypocellularity	BRCA2 SLX4	1.11e-03	18	81	2	C1855710
Disease	disease free survival	ICE1 CCDC168	1.11e-03	18	81	2	EFO_0000409
Disease	diet measurement, HOMA-B	KLHL1 FAT3	1.23e-03	19	81	2	EFO_0004469, EFO_0008111
Disease	polycystic kidney disease (biomarker_via_orthology)	GNAS CTSH	1.23e-03	19	81	2	DOID:0080322 (biomarker_via_orthology)
Disease	Fanconi Anemia	BRCA2 SLX4	2.14e-03	25	81	2	C0015625
Disease	Pancytopenia	BRCA2 SLX4	2.32e-03	26	81	2	C0030312
Disease	retinitis pigmentosa (implicated_via_orthology)	RPGRIP1 RHO	2.50e-03	27	81	2	DOID:10584 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DTVVFYDNDLNPVMD	EP400	1986	Q96L91
EVSEVIPVMTNNYEE	C6orf62	51	Q9GZU0
NITFEYMFEEVPIVI	EIF3H	191	O15372
VNEVPSFYVPMVDVN	ANKRD11	2641	Q6UB99
SFYVPMVDVNDDFVL	ANKRD11	2646	Q6UB99
TVFEVEDENMVLASY	ASB4	46	Q9Y574
DVVTEAIYPEAVTMF	PPP2R5D	161	Q14738
VMTIPEENETGFDFV	DOP1A	1596	Q5JWR5
QPEEIIYFETDKSMV	CC2D2B	1296	Q6DHV5
VQDAYLMPSFSEVEQ	RASSF9	231	O75901
DMKEVIEIDQFSYPV	RCBTB1	406	Q8NDN9
NEDDIVEMSEFSYPV	RCBTB2	426	O95199
PEVNNESFVIYMFVV	RHO	196	P08100
MEAAAQFFVESPDVV	ISYNA1	1	Q9NPH2
AMETAVPVYFAVEDE	NCLN	136	Q969V3
DLYVTEEAQVFETVM	KLHL6	226	Q8WZ60
PGVDYIFITVEDFME	MAGI2	151	Q86UL8
YIPEVEGVEQVMDDE	NFU1	231	Q9UMS0
FEEEIMSYVPLQAAF	HECW1	1176	Q76N89
AFSMESIDDYVNVPE	LAT	191	O43561
DDMYMDFEEVISSPV	KIAA1109	756	Q2LD37
MVADYEPEEEEIQTV	TMEM63C	711	Q9P1W3
YMAPEVVEAFSEEAS	MKNK2	256	Q9HBH9
EVAKAFPERVYVMED	GAREM1	111	Q9H706
FPERVYVMEDITFNV	GAREM1	116	Q9H706
PVSDTEMEYTIDVFF	GABRA5	86	P31644
EELFQAIMEQTVTYP	PRKCG	561	P05129
FVTYDPMDEIQIAEI	KIF9	381	Q9HAQ2
YVLMVEDDAVPEEQI	PGAP4	206	Q9BRR3
VSDYINANIIMPEFE	PTPN11	301	Q06124
VPAAFVLEDVDFDQM	MFAP3	16	P55082
YDVMQDPEFLQSVLE	PIPSL	811	A2A3N6
DEFVSVLPMEYENNS	PTPRO	311	Q16827
QADDQDMVEPLFYTV	OR5H1	266	A6NKK0
PIIDVISDDTFEYMA	GALNT1	236	Q10472
YGEAVVEPEMSNADI	CEP104	391	O60308
VVQIENIMVFAEAYD	HYDIN	3026	Q4G0P3
PVMRDQEKEVVYEFS	ICE1	1946	Q9Y2F5
IVDDFLTPENDYEEM	GRID2IP	696	A4D2P6
VVAVDSYMPVIDVFS	C2CD3	926	Q4AC94
SMPNVLEDEVYETVV	BRCA2	286	P51587
EFLNMVPDTEAEVFI	C3P1	151	Q6ZMU1
EIQMSVEQIDPSTEY	FER	246	P16591
EIVDPNVDEHSVMTY	FLNA	246	P21333
LNEIDFYEAFMEEPV	CASQ1	226	P31415
VDENDNAPQFMTVEY	FAT3	2591	Q8TDW7
DMRVVYDTFVKPDNE	REXO1L1P	526	Q8IX06
GESVPEYQMAFQTEV	BMPR2	426	Q13873
TELMELQEFYDPDTV	DPY19L4	551	Q7Z388
MESYDVIANQPVVID	ACTR1A	1	P61163
EEAMVEAVALYNPVS	CTSH	236	P09668
ETPTQIQEMFDEVSY	ERAP2	441	Q6P179
ITMFIPSDVDNYDDI	EML4	236	Q9HC35
PMEEEEVETFAFQAE	HSP90AA1	11	P07900
VDYIMQPEGTIFEAE	CCDC168	4511	Q8NDH2
VVAVNDPFIDPEYMV	GAPDHS	101	O14556
YDVMQDPEFLQSVLE	PSMD4	326	P55036
DIPVQQITYTMDTED	SACS	2796	Q9NZJ4
PMEEEEVETFAFQAE	HSP90AA2P	11	Q14568
EEISGRPEMVFYVEN	COL6A6	766	A6NMZ7
EYMAPEVVEVFTDQA	MKNK1	261	Q9BUB5
QEEPVYIEMVGDVFR	NYAP1	211	Q6ZVC0
PEFIVQTSSYMFVDE	RTL8A	41	Q9BWD3
PEFIVQTSSYMFVDE	RTL8B	41	Q17RB0
PAEDVDSFEMEFYEV	TRIM42	626	Q8IWZ5
EIVSLAFYPEAEVMS	RPGRIP1	1121	Q96KN7
VDFYAPTAAVESMVE	MRPS6	66	P82932
ASYEVMQIDVEVEEP	TMEM132D	376	Q14C87
YVMDVEEITPAIVEA	NXN	406	Q6DKJ4
FVLQDMESDIIPEDY	SKAP2	216	O75563
VDYILSVMNVPDFDF	GNAS	771	Q5JWF2
VYQAEMDELPAAFVD	RGMA	231	Q96B86
EAVGQDEAVYMEEVP	AARS2	686	Q5JTZ9
VNEAEMEEIYEFAAT	SLX4	846	Q8IY92
MESGYTRIPVFEDEQ	CNNM4	401	Q6P4Q7
SVFVPVNDSVYAVVM	PLET1	61	Q6UQ28
PVYVESQLMDADLEV	TMEM210	101	A6NLX4
EASEFIVYVQEAMQP	ZFAT	1216	Q9P243
DMATNPDYYTEVVEQ	TBC1D8B	506	Q0IIM8
VPAVYFVMPTEENID	SCFD1	86	Q8WVM8
VFPYQDEMSDVVVQP	TUBG2	171	Q9NRH3
DVPEDVAQEMVESGY	WNK1	531	Q9H4A3
PQDVVVARYEEAMFH	PTK7	231	Q13308
QVTRGDVFTMPEDEY	VTN	61	P04004
SPEEIAAAMVYNEFI	WNK4	711	Q96J92
IYTIFQEMAKFEEPD	UNC79	956	Q9P2D8
APEDIADYMVEDNFV	WNK3	781	Q9BYP7
YVESLEEEVVPGMDF	KLHL1	121	Q9NR64