Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	premeiotic DNA replication	MCM4 MCM6	3.94e-05	6	34	2	GO:0006279
GeneOntologyCellularComponent	MCM complex	MCM4 MCM6	1.40e-04	11	34	2	GO:0042555
GeneOntologyCellularComponent	CMG complex	MCM4 MCM6	1.40e-04	11	34	2	GO:0071162
GeneOntologyCellularComponent	DNA replication preinitiation complex	MCM4 MCM6	1.98e-04	13	34	2	GO:0031261
Domain	Coagulation_fac_subgr_Gla_dom	PRRG3 F9 F10	1.09e-06	12	33	3	IPR017857
Domain	-	PRRG3 F9 F10	1.09e-06	12	33	3	4.10.740.10
Domain	GLA	PRRG3 F9 F10	1.81e-06	14	33	3	SM00069
Domain	Gla	PRRG3 F9 F10	1.81e-06	14	33	3	PF00594
Domain	GLA_1	PRRG3 F9 F10	1.81e-06	14	33	3	PS00011
Domain	GLA_domain	PRRG3 F9 F10	1.81e-06	14	33	3	IPR000294
Domain	GLA_2	PRRG3 F9 F10	1.81e-06	14	33	3	PS50998
Domain	Rubredoxin-type_fold	MCM4 MCM6	1.81e-05	4	33	2	IPR004039
Domain	-	MCM4 MCM6	1.81e-05	4	33	2	2.20.28.10
Domain	Pept_S1A_FX	F9 F10	3.02e-05	5	33	2	IPR012224
Domain	MCM_N	MCM4 MCM6	4.52e-05	6	33	2	PF14551
Domain	MCM_CS	MCM4 MCM6	4.52e-05	6	33	2	IPR018525
Domain	MCM_N	MCM4 MCM6	4.52e-05	6	33	2	IPR027925
Domain	EGF	LRP2 MALRD1 F9 F10	6.94e-05	126	33	4	PF00008
Domain	MCM_OB	MCM4 MCM6	8.42e-05	8	33	2	PF17207
Domain	MCM_OB	MCM4 MCM6	8.42e-05	8	33	2	IPR033762
Domain	MCM_2	MCM4 MCM6	8.42e-05	8	33	2	PS50051
Domain	MCM_1	MCM4 MCM6	8.42e-05	8	33	2	PS00847
Domain	MCM	MCM4 MCM6	1.08e-04	9	33	2	SM00350
Domain	MCM_dom	MCM4 MCM6	1.08e-04	9	33	2	IPR001208
Domain	MCM	MCM4 MCM6	1.08e-04	9	33	2	PF00493
Domain	MCM	MCM4 MCM6	1.08e-04	9	33	2	IPR031327
Domain	EGF_Ca-bd_CS	LRP2 F9 F10	6.62e-04	97	33	3	IPR018097
Domain	EGF_CA	LRP2 F9 F10	7.02e-04	99	33	3	PS01187
Domain	ASX_HYDROXYL	LRP2 F9 F10	7.23e-04	100	33	3	PS00010
Domain	EGF_3	LRP2 MALRD1 F9 F10	7.51e-04	235	33	4	PS50026
Domain	EGF	LRP2 MALRD1 F9 F10	7.51e-04	235	33	4	SM00181
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP2 F9 F10	8.57e-04	106	33	3	IPR000152
Domain	EGF-like_dom	LRP2 MALRD1 F9 F10	9.31e-04	249	33	4	IPR000742
Domain	EGF_1	LRP2 MALRD1 F9 F10	1.02e-03	255	33	4	PS00022
Domain	EGF-like_CS	LRP2 MALRD1 F9 F10	1.11e-03	261	33	4	IPR013032
Domain	EGF_2	LRP2 MALRD1 F9 F10	1.17e-03	265	33	4	PS01186
Domain	EGF_CA	LRP2 F9 F10	1.29e-03	122	33	3	SM00179
Domain	EGF-like_Ca-bd_dom	LRP2 F9 F10	1.35e-03	124	33	3	IPR001881
Domain	LDLR_class-A_CS	LRP2 MALRD1	2.26e-03	40	33	2	IPR023415
Domain	Ldl_recept_a	LRP2 MALRD1	2.86e-03	45	33	2	PF00057
Domain	-	LRP2 MALRD1	2.98e-03	46	33	2	4.10.400.10
Domain	LDLRA_1	LRP2 MALRD1	3.25e-03	48	33	2	PS01209
Domain	LDrepeatLR_classA_rpt	LRP2 MALRD1	3.38e-03	49	33	2	IPR002172
Domain	LDLa	LRP2 MALRD1	3.38e-03	49	33	2	SM00192
Domain	LDLRA_2	LRP2 MALRD1	3.38e-03	49	33	2	PS50068
Domain	NA-bd_OB-fold	MCM4 MCM6	9.42e-03	83	33	2	IPR012340
Pathway	REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS	RAD9B MCM4 MCM6	2.28e-05	36	22	3	MM14687
Pathway	REACTOME_EXTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F9 F10	2.32e-05	5	22	2	M26948
Pathway	REACTOME_EXTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F9 F10	2.32e-05	5	22	2	MM14556
Pathway	REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS	RAD9B MCM4 MCM6	2.48e-05	37	22	3	M11153
Pathway	REACTOME_DEFECTIVE_FACTOR_VIII_CAUSES_HEMOPHILIA_A	F9 F10	4.86e-05	7	22	2	M39000
Pathway	KEGG_MEDICUS_REFERENCE_BREAK_INDUCED_REPLICATION	MCM4 MCM6	6.47e-05	8	22	2	M47840
Pathway	REACTOME_TRANSPORT_OF_GAMMA_CARBOXYLATED_PROTEIN_PRECURSORS_FROM_THE_ENDOPLASMIC_RETICULUM_TO_THE_GOLGI_APPARATUS	F9 F10	8.31e-05	9	22	2	MM14614
Pathway	REACTOME_GAMMA_CARBOXYLATION_OF_PROTEIN_PRECURSORS	F9 F10	8.31e-05	9	22	2	MM14613
Pathway	REACTOME_DEFECTIVE_FACTOR_IX_CAUSES_HEMOPHILIA_B	F9 F10	8.31e-05	9	22	2	M39001
Pathway	REACTOME_REMOVAL_OF_AMINOTERMINAL_PROPEPTIDES_FROM_GAMMA_CARBOXYLATED_PROTEINS	F9 F10	1.04e-04	10	22	2	M26977
Pathway	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	F9 F10	1.27e-04	11	22	2	M12484
Pathway	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	F9 F10	1.27e-04	11	22	2	MM14615
Pathway	REACTOME_UNWINDING_OF_DNA	MCM4 MCM6	1.52e-04	12	22	2	M3656
Pathway	BIOCARTA_MCM_PATHWAY	MCM4 MCM6	1.79e-04	13	22	2	MM1363
Pathway	WP_VITAMIN_K_METABOLISM_AND_ACTIVATION_OF_DEPENDENT_PROTEINS	F9 F10	1.79e-04	13	22	2	M45518
Pathway	REACTOME_DEFECTS_OF_CONTACT_ACTIVATION_SYSTEM_CAS_AND_KALLIKREIN_KININ_SYSTEM_KKS	F9 F10	2.75e-04	16	22	2	M38996
Pathway	KEGG_MEDICUS_REFERENCE_TRAIP_DEPENDENT_REPLISOME_DISASSEMBLY	MCM4 MCM6	2.75e-04	16	22	2	M47862
Pathway	BIOCARTA_MCM_PATHWAY	MCM4 MCM6	3.50e-04	18	22	2	M6682
Pathway	REACTOME_DISEASES_OF_HEMOSTASIS	F9 F10	3.91e-04	19	22	2	M48230
Pathway	KEGG_MEDICUS_REFERENCE_DNA_REPLICATION_TERMINATION	MCM4 MCM6	4.80e-04	21	22	2	M47861
Pathway	WP_BLOOD_CLOTTING_CASCADE	F9 F10	5.27e-04	22	22	2	M39480
Pathway	BIOCARTA_INTRINSIC_PATHWAY	F9 F10	5.77e-04	23	22	2	M15997
Pathway	REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F9 F10	5.77e-04	23	22	2	M14766
Pathway	BIOCARTA_INTRINSIC_PATHWAY	F9 F10	5.77e-04	23	22	2	MM1427
Pathway	WP_BLOOD_CLOTTING_CASCADE	F9 F10	5.77e-04	23	22	2	MM15936
Pathway	REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION	F9 F10	5.77e-04	23	22	2	MM14557
Pathway	KEGG_MEDICUS_REFERENCE_DNA_REPLICATION_LICENSING	MCM4 MCM6	6.28e-04	24	22	2	M47857
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	COP1 RAD9B MCM4 MCM6	7.44e-04	271	22	4	MM15388
Pathway	KEGG_MEDICUS_REFERENCE_PRE_IC_FORMATION	MCM4 MCM6	7.97e-04	27	22	2	M47858
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	COP1 RAD9B MCM4 MCM6	9.70e-04	291	22	4	M16647
Pathway	KEGG_MEDICUS_REFERENCE_ORIGIN_UNWINDING_AND_ELONGATION	MCM4 MCM6	9.85e-04	30	22	2	M47859
Pathway	REACTOME_DNA_STRAND_ELONGATION	MCM4 MCM6	1.12e-03	32	22	2	M19312
Pathway	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	MCM4 MCM6	1.12e-03	32	22	2	MM15368
Pathway	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	MCM4 MCM6	1.19e-03	33	22	2	M9694
Pathway	REACTOME_G2_M_CHECKPOINTS	RAD9B MCM4 MCM6	1.37e-03	143	22	3	MM15383
Pathway	KEGG_DNA_REPLICATION	MCM4 MCM6	1.42e-03	36	22	2	M16853
Pathway	REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE	F9 F10	1.66e-03	39	22	2	M2844
Pathway	REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE	F9 F10	1.66e-03	39	22	2	MM14559
Pathway	WP_DNA_REPLICATION	MCM4 MCM6	1.93e-03	42	22	2	M39335
Pathway	REACTOME_G2_M_CHECKPOINTS	RAD9B MCM4 MCM6	2.13e-03	167	22	3	M19381
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP11C UNC79 RYR3	2.47e-03	176	22	3	MM15718
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	ATP11C UNC79 RYR3	2.76e-03	183	22	3	M997
Pathway	REACTOME_GAMMA_CARBOXYLATION_HYPUSINYLATION_HYDROXYLATION_AND_ARYLSULFATASE_ACTIVATION	F9 F10	3.52e-03	57	22	2	MM14634
Pathway	WP_COMPLEMENT_AND_COAGULATION_CASCADES	F9 F10	3.65e-03	58	22	2	M39649
Pathway	REACTOME_CELL_CYCLE	COP1 RAD9B MCM4 MCM6 PCNT	3.73e-03	694	22	5	M543
Pathway	WP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES	F9 F10	3.77e-03	59	22	2	M48343
Pathway	REACTOME_GAMMA_CARBOXYLATION_HYPUSINYLATION_HYDROXYLATION_AND_ARYLSULFATASE_ACTIVATION	F9 F10	4.02e-03	61	22	2	M26993
Pathway	WP_G1_TO_S_CELL_CYCLE_CONTROL	MCM4 MCM6	4.02e-03	61	22	2	MM15912
Pathway	WP_G1_TO_S_CELL_CYCLE_CONTROL	MCM4 MCM6	4.42e-03	64	22	2	M39627
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	F9 F10	5.12e-03	69	22	2	M16894
Pathway	REACTOME_ORC1_REMOVAL_FROM_CHROMATIN	MCM4 MCM6	5.12e-03	69	22	2	MM15366
Pathway	REACTOME_ORC1_REMOVAL_FROM_CHROMATIN	MCM4 MCM6	5.41e-03	71	22	2	M4138
Pathway	REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX	MCM4 MCM6	6.99e-03	81	22	2	MM15360
Pathway	WP_RETINOBLASTOMA_GENE_IN_CANCER	MCM4 MCM6	8.57e-03	90	22	2	M39678
Pathway	REACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE	MCM4 MCM6	8.57e-03	90	22	2	MM15371
Pathway	REACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE	MCM4 MCM6	8.94e-03	92	22	2	M27666
Pathway	WP_COMPLEMENT_SYSTEM	LRP2 F10	9.70e-03	96	22	2	M39581
Pathway	REACTOME_DNA_REPLICATION_PRE_INITIATION	MCM4 MCM6	9.90e-03	97	22	2	MM15369
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	UNC79 RYR3	1.03e-02	99	22	2	MM14910
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	RIF1 NKD1 GRSF1	1.10e-02	301	22	3	MM15983
Pathway	REACTOME_CARDIAC_CONDUCTION	KCND2 RYR3	1.11e-02	103	22	2	MM15196
Pathway	REACTOME_G1_S_TRANSITION	MCM4 MCM6	1.13e-02	104	22	2	MM15376
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	UNC79 RYR3	1.17e-02	106	22	2	M27200
Pubmed	Coagulation factors IX and X enhance binding and infection of adenovirus types 5 and 31 in human epithelial cells.	F9 F10	9.28e-07	2	34	2	19158249
Pubmed	Allosteric activation of antithrombin critically depends upon hinge region extension.	F9 F10	9.28e-07	2	34	2	15326167
Pubmed	Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa.	F9 F10	9.28e-07	2	34	2	16517611
Pubmed	Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III.	F9 F10	9.28e-07	2	34	2	14963035
Pubmed	Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets.	F9 F10	9.28e-07	2	34	2	15328360
Pubmed	Processive DNA helicase activity of the minichromosome maintenance proteins 4, 6, and 7 complex requires forked DNA structures.	MCM4 MCM6	9.28e-07	2	34	2	11136247
Pubmed	Kinetics of coagulation factor X activation by platelet-bound factor IXa.	F9 F10	2.78e-06	3	34	2	2110473
Pubmed	Binding studies of the enzyme (factor IXa) with the cofactor (factor VIIIa) in the assembly of factor-X activating complex on the activated platelet surface.	F9 F10	2.78e-06	3	34	2	14629468
Pubmed	MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.	MCM4 MCM6	2.78e-06	3	34	2	31476594
Pubmed	Physiological levels of blood coagulation factors IX and X control coagulation kinetics in an in vitro model of circulating tissue factor.	F9 F10	2.78e-06	3	34	2	23585459
Pubmed	G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.	MCM4 MCM6	2.78e-06	3	34	2	25661590
Pubmed	An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.	MCM4 MCM6	2.78e-06	3	34	2	27794528
Pubmed	Localization of an antithrombin exosite that promotes rapid inhibition of factors Xa and IXa dependent on heparin activation of the serpin.	F9 F10	2.78e-06	3	34	2	14532267
Pubmed	Mouse MCM proteins: complex formation and transportation to the nucleus.	MCM4 MCM6	2.78e-06	3	34	2	9077461
Pubmed	Function of the amino-terminal region of human MCM4 in helicase activity.	MCM4 MCM6	2.78e-06	3	34	2	30184107
Pubmed	DNA binding and helicase actions of mouse MCM4/6/7 helicase.	MCM4 MCM6	2.78e-06	3	34	2	15917436
Pubmed	The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D.	F9 F10	2.78e-06	3	34	2	24068708
Pubmed	A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.	MCM4 MCM6	2.78e-06	3	34	2	9305914
Pubmed	Intrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque.	F9 F10	2.78e-06	3	34	2	12036878
Pubmed	Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.	RAD9B MCM4 MCM6	5.00e-06	34	34	3	12791985
Pubmed	Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.	MCM4 MCM6	5.56e-06	4	34	2	20421204
Pubmed	Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity.	MCM4 MCM6	5.56e-06	4	34	2	10567526
Pubmed	Cdt1 forms a complex with the minichromosome maintenance protein (MCM) and activates its helicase activity.	MCM4 MCM6	5.56e-06	4	34	2	18606811
Pubmed	UBE3A and MCM6 synergistically regulate the proliferation and migration of lung adenocarcinoma cells.	MCM4 MCM6	5.56e-06	4	34	2	37454373
Pubmed	IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus.	PER2 KCND2	5.56e-06	4	34	2	26152125
Pubmed	Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.	MCM4 MCM6	5.56e-06	4	34	2	12207017
Pubmed	The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII--tissue factor complex.	F9 F10	5.56e-06	4	34	2	15634274
Pubmed	Mammalian Mcm2/4/6/7 complex forms a toroidal structure.	MCM4 MCM6	5.56e-06	4	34	2	12694531
Pubmed	Inhibition of tissue factor:factor VIIa-catalyzed factor IX and factor X activation by TFPI and TFPI constructs.	F9 F10	9.26e-06	5	34	2	25163770
Pubmed	Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.	MCM4 MCM6	9.26e-06	5	34	2	20838603
Pubmed	Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2.	MCM4 MCM6	9.26e-06	5	34	2	10748114
Pubmed	Tissue factor pathway inhibitor and the revised theory of coagulation.	F9 F10	9.26e-06	5	34	2	7598447
Pubmed	A new member of the MCM protein family encoded by the human MCM8 gene, located contrapodal to GCD10 at chromosome band 20p12.3-13.	MCM4 MCM6	9.26e-06	5	34	2	12771218
Pubmed	Pairwise interactions of the six human MCM protein subunits.	MCM4 MCM6	1.39e-05	6	34	2	15236977
Pubmed	Human Mcm proteins at a replication origin during the G1 to S phase transition.	MCM4 MCM6	1.39e-05	6	34	2	12364596
Pubmed	Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload.	MCM4 MCM6	1.39e-05	6	34	2	21220507
Pubmed	The eukaryotic Mcm2-7 replicative helicase.	MCM4 MCM6	1.39e-05	6	34	2	22918583
Pubmed	In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.	MCM4 MCM6	1.39e-05	6	34	2	9099751
Pubmed	O-GlcNAc transferase associates with the MCM2-7 complex and its silencing destabilizes MCM-MCM interactions.	MCM4 MCM6	1.94e-05	7	34	2	30069701
Pubmed	VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.	F9 F10	1.94e-05	7	34	2	29321368
Pubmed	Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma.	MCM4 MCM6	1.94e-05	7	34	2	11248027
Pubmed	Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.	MCM4 MCM6	1.94e-05	7	34	2	24038355
Pubmed	Identification and characterization of a novel component of the human minichromosome maintenance complex.	MCM4 MCM6	1.94e-05	7	34	2	17296731
Pubmed	Interaction of chromatin-associated Plk1 and Mcm7.	MCM4 MCM6	1.94e-05	7	34	2	15654075
Pubmed	Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.	MCM4 MCM6	1.94e-05	7	34	2	23764002
Pubmed	A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.	LRP2 PCNT	1.94e-05	7	34	2	15314648
Pubmed	Binding of human minichromosome maintenance proteins with histone H3.	MCM4 MCM6	1.94e-05	7	34	2	8798650
Pubmed	Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.	MCM4 MCM6	2.59e-05	8	34	2	16899510
Pubmed	A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden.	F9 F10	2.59e-05	8	34	2	23472758
Pubmed	Female-biased embryonic death from inflammation induced by genomic instability.	MCM4 MCM6	2.59e-05	8	34	2	30787433
Pubmed	FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.	MCM4 MCM6	2.59e-05	8	34	2	23993743
Pubmed	Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.	MCM4 MCM6	3.33e-05	9	34	2	10846177
Pubmed	The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.	MCM4 MCM6	3.33e-05	9	34	2	25049228
Pubmed	L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.	MCM4 MCM6	3.33e-05	9	34	2	21149733
Pubmed	Keap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa.	MCM4 MCM6	3.33e-05	9	34	2	30108253
Pubmed	A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.	MCM4 MCM6	4.15e-05	10	34	2	21055985
Pubmed	Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication.	MCM4 MCM6	4.15e-05	10	34	2	16902406
Pubmed	USP7 is a novel Deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis.	MCM4 MCM6	5.07e-05	11	34	2	31730000
Pubmed	Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex.	MCM4 MCM6	5.07e-05	11	34	2	30100344
Pubmed	Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7.	MCM4 MCM6	6.08e-05	12	34	2	24299456
Pubmed	Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.	MCM4 MCM6	6.08e-05	12	34	2	22474384
Pubmed	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression.	MCM4 MCM6	6.08e-05	12	34	2	30479348
Pubmed	Protein interaction and cellular localization of human CDC45.	MCM4 MCM6	7.19e-05	13	34	2	23364835
Pubmed	Interactions of the human MCM-BP protein with MCM complex components and Dbf4.	MCM4 MCM6	7.19e-05	13	34	2	22540012
Pubmed	The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.	MCM4 MCM6 RIF1	7.70e-05	84	34	3	26299517
Pubmed	The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.	MCM4 MCM6	9.66e-05	15	34	2	10436018
Pubmed	MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.	MCM4 MCM6	9.66e-05	15	34	2	19696745
Pubmed	Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply.	MCM4 MCM6	9.66e-05	15	34	2	22407294
Pubmed	The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.	MCM4 MCM6	1.10e-04	16	34	2	11095689
Pubmed	Identification of proteins that may directly interact with human RPA.	MCM4 MCM6	1.25e-04	17	34	2	20679368
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	MCM4 MCM6 PCNT	1.37e-04	102	34	3	20508983
Pubmed	DNA replication in eukaryotic cells.	MCM4 MCM6	1.41e-04	18	34	2	12045100
Pubmed	Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.	MCM4 MCM6	1.41e-04	18	34	2	28191891
Pubmed	Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.	MCM4 MCM6	1.57e-04	19	34	2	15226314
Pubmed	Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.	MCM4 MCM6	1.74e-04	20	34	2	18162579
Pubmed	Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.	MCM4 MCM6	1.74e-04	20	34	2	12614612
Pubmed	Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.	COP1 PER2	1.74e-04	20	34	2	31155351
Pubmed	PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates.	KCND2 RYR3	1.93e-04	21	34	2	39304345
Pubmed	RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.	MCM4 MCM6	1.93e-04	21	34	2	21113133
Pubmed	Programmed cell senescence during mammalian embryonic development.	NKD1 PCNT	1.93e-04	21	34	2	24238962
Pubmed	A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus.	MCM4 MCM6	1.93e-04	21	34	2	20808282
Pubmed	Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage.	MCM4 MCM6	2.12e-04	22	34	2	24780295
Pubmed	DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.	MCM4 MCM6	2.12e-04	22	34	2	15707391
Pubmed	Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.	LRP2 F9	2.12e-04	22	34	2	12768436
Pubmed	Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.	MCM4 MCM6	2.53e-04	24	34	2	34195792
Pubmed	Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.	MCM4 MCM6	2.74e-04	25	34	2	27621311
Pubmed	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.	MCM4 MCM6	2.97e-04	26	34	2	34162889
Pubmed	Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.	MCM4 MCM6	2.97e-04	26	34	2	11931757
Pubmed	Analysis of interaction partners of H4 histone by a new proteomics approach.	MCM4 MCM6	3.21e-04	27	34	2	19862764
Pubmed	TRAIP regulates replication fork recovery and progression via PCNA.	MCM4 MCM6	3.21e-04	27	34	2	27462463
Pubmed	Self-assembling protein microarrays.	MCM4 MCM6	3.97e-04	30	34	2	15232106
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	MCM4 MCM6 RIF1	4.52e-04	153	34	3	26365490
Pubmed	Atypical E2F repressors and activators coordinate placental development.	MCM4 MCM6	4.81e-04	33	34	2	22516201
Pubmed	Early embryonic expression of murine coagulation system components.	F9 F10	5.10e-04	34	34	2	11154109
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	LRP2 TSTD2 GRSF1 TRIM37 MADD PCNT	5.76e-04	1084	34	6	11544199
Pubmed	Large-scale identification of mammalian proteins localized to nuclear sub-compartments.	MCM6 PCNT	6.38e-04	38	34	2	11555636
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PER2 ZBED4 MADD PCNT	6.49e-04	407	34	4	12693553
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	MCM4 MCM6 RIF1	7.25e-04	180	34	3	30110629
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	MCM4 MCM6	7.79e-04	42	34	2	16387653
Interaction	HMGA1 interactions	MCM4 MCM6 RIF1 PER2 UNC79 GRSF1 TRIM37	4.28e-06	419	33	7	int:HMGA1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq27	ATP11C F9	2.09e-03	91	34	2	chrXq27
GeneFamily	MCM family	MCM4 MCM6	5.54e-05	9	23	2	1085
GeneFamily	Gla domain containing	F9 F10	1.20e-04	13	23	2	1250
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRP2 MCM6 PRRG3 PCNT	8.35e-06	170	34	4	4ce81608111b9ee7cb974dad2c182f38db3dcd79
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 SNX30 NKAIN3 UNC79	1.07e-05	181	34	4	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 SNX30 NKAIN3 UNC79	1.07e-05	181	34	4	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	droplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MORC1 MCM4 MCM6 UNC79	1.32e-05	191	34	4	c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
Drug	S 2160	F9 TRIM37 F10	3.11e-06	20	33	3	CID000189147
Drug	AC1NDU2A	F9 F10	1.22e-05	4	33	2	CID004631608
Drug	Gamma-Carboxy-Glutamic Acid	F9 F10	1.22e-05	4	33	2	DB03847
Drug	Pentosan Sulfuric Polyester	F9 F10	3.04e-05	6	33	2	ctd:D010426
Drug	Gla 40	F9 F10	3.04e-05	6	33	2	CID000160340
Drug	heparin pentasaccharide	MCM4 RIF1 F9 F10	5.44e-05	144	33	4	CID000444410
Drug	dihydroxyacetophenone	F9 F10	5.67e-05	8	33	2	CID000099611
Drug	Pradax	F9 F10	9.10e-05	10	33	2	CID006445226
Drug	CI-1031	F9 F10	1.11e-04	11	33	2	CID005353802
Drug	Antihemophilic Factor	F9 F10	1.11e-04	11	33	2	DB00025
Drug	S 2288	F9 F10	1.33e-04	12	33	2	CID000122006
Drug	5-amidinoindole	F9 F10	1.33e-04	12	33	2	CID000122670
Drug	Menadione	F9 F10	1.57e-04	13	33	2	DB00170
Drug	dansylphosphatidylethanolamine	F9 F10	1.57e-04	13	33	2	CID000169871
Drug	dabigatran	F9 F10	1.83e-04	14	33	2	CID000216210
Drug	C4 m	LRP2 F9 F10	2.04e-04	79	33	3	CID009543487
Drug	Contraceptives, Oral	F9 F10	2.11e-04	15	33	2	ctd:D003276
Drug	AC1LAFI2	F9 F10	2.11e-04	15	33	2	CID000467477
Drug	CID6326984	COP1 F10	2.11e-04	15	33	2	CID006326984
Drug	Xyl-Glc	F9 F10	2.11e-04	15	33	2	CID003083150
Disease	Thrombus	F9 F10	1.14e-03	46	32	2	C0087086
Disease	alcohol use disorder (implicated_via_orthology)	UNC79 RYR3 MADD	1.22e-03	195	32	3	DOID:1574 (implicated_via_orthology)
Disease	Thrombosis	F9 F10	1.30e-03	49	32	2	C0040053
Disease	lung adenocarcinoma, family history of lung cancer	MALRD1 SASH1	1.41e-03	51	32	2	EFO_0000571, EFO_0006953
Disease	response to cranial radiation therapy, short-term memory	MALRD1 SASH1	1.94e-03	60	32	2	EFO_0004335, EFO_0010950
Disease	disease progression measurement	NKAIN3 RYR3	2.00e-03	61	32	2	EFO_0008336
Disease	Major Depressive Disorder	MORC1 GMIP PCNT	2.29e-03	243	32	3	C1269683
Disease	Unipolar Depression	MORC1 GMIP PCNT	2.75e-03	259	32	3	C0041696
Disease	unipolar depression, alcohol dependence	RIF1 SASH1	3.25e-03	78	32	2	EFO_0003761, MONDO_0007079

Protein segments in the cluster

Peptide	Gene	Start	Entry
SNDFVCPICFDMIEE	COP1	131	Q8NHY2
QMCEARDSVPLEFEC	CPNE2	251	Q96FN4
MERFCNDLCVDPTEF	DCUN1D3	111	Q8IWE4
FEELQCDVSMEEDSR	NKD1	121	Q969G9
CTMEDVLNFFSDCRI	GRSF1	161	Q12849
EETMTCVFFSQTFCE	MORC1	121	Q86VD1
DSEEDMNNVCCRKEF	RAD9B	401	Q6WBX8
CCIDEFDKMNESTRS	MCM4	571	P33991
VCCIDEFDKMDVRDQ	MCM6	456	Q14566
SMEEEDTYSCDLQVC	NKAIN3	171	Q8N8D7
TNGDIFFMEVCDDCV	MADD	1451	Q8WXG6
FFMEVCDDCVVLRSN	MADD	1456	Q8WXG6
RECEAFMVSGTECEE	GMIP	506	Q9P107
TQECMEEKSFFCRVS	PER2	261	O15055
ERECMEEKCSFEEAR	F9	61	P00740
HEFVDEQVFEESCME	KCND2	491	Q9NZV8
VDIDECTEMPFVCSQ	LRP2	3151	P98164
EQRGMFTKECEQECE	PCNT	206	O95613
CFIFQRTCSEEMEEE	OR5H6	6	Q8NGV6
DEASCVMEVCSFEKR	MALRD1	1081	Q5VYJ5
YQECCTIAMTEEVED	CCDC82	486	Q8N4S0
ECMEETCSYEEAREV	F10	56	P00742
VESIAEVFRCFICME	TRIM37	6	O94972
IVNFREEICDMDSSE	RIF1	1831	Q5UIP0
CQAEAAFMEEECVDT	SIK2	406	Q9H0K1
FDKQELEERMSRCCF	HERC2P3	1111	Q9BVR0
TLTENSMEFIECCID	ATP11C	416	Q8NB49
SEMFTQCVFCRIDTR	WDR88	431	Q6ZMY6
DVEKCQDRMECFNAD	SNX30	371	Q5VWJ9
EQVREDMETKCFICG	RYR3	4781	Q15413
NTCFSDVCERMEELR	SASH1	71	O94885
MQDSFKEECECTARR	TSTD2	471	Q5T7W7
TIERECMEEICSYEE	PRRG3	31	Q9BZD7
TIDFDCEDDEMNLNC	UNC79	786	Q9P2D8
EMSVECNFRELISCD	ZBED4	911	O75132