Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sialic acid binding	SELP SIGLEC9 SIGLEC16 SIGLEC11	3.29e-07	25	47	4	GO:0033691
GeneOntologyMolecularFunction	poly(G) binding	HNRNPDL PATL2	2.41e-04	10	47	2	GO:0034046
Domain	PSI	SEMA4F MEGF8 PLXNC1	7.50e-05	32	48	3	PF01437
Domain	Plexin_repeat	SEMA4F MEGF8 PLXNC1	7.50e-05	32	48	3	IPR002165
Domain	PSI	SEMA4F MEGF8 PLXNC1	1.96e-04	44	48	3	IPR016201
Domain	PSI	SEMA4F MEGF8 PLXNC1	2.24e-04	46	48	3	SM00423
Domain	Gal_Oxase/kelch_b-propeller	MEGF8 WDR6 KLHDC8B	4.68e-04	59	48	3	IPR011043
Pubmed	Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.	SIGLEC9 SIGLEC16 SIGLEC11	9.16e-08	7	49	3	28100677
Pubmed	CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder.	SIGLEC9 SIGLEC16 SIGLEC11	7.44e-07	13	49	3	35921817
Pubmed	A human-specific gene in microglia.	SIGLEC16 SIGLEC11	1.94e-06	2	49	2	16151003
Pubmed	SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.	SIGLEC16 SIGLEC11	1.94e-06	2	49	2	18629938
Pubmed	Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform.	SELP IRAK1	1.94e-06	2	49	2	18050247
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	SIGLEC9 SIGLEC16 SIGLEC11	5.21e-06	24	49	3	15331780
Pubmed	SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.	SIGLEC16 SIGLEC11	5.83e-06	3	49	2	24859880
Pubmed	Characterisation of transcription factor profiles in polycystic kidney disease (PKD): identification and validation of STAT3 and RUNX1 in the injury/repair response and PKD progression.	PKD1 RUNX1	5.83e-06	3	49	2	31773180
Pubmed	The role of Siglec-G on B cells in autoimmune disease and leukemia.	SIGLEC16 SIGLEC11	5.83e-06	3	49	2	38042621
Pubmed	The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.	SIGLEC16 SIGLEC11	5.83e-06	3	49	2	24790146
Pubmed	Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population.	SIGLEC16 SIGLEC11	5.83e-06	3	49	2	17572677
Pubmed	Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.	SIGLEC16 SIGLEC11	5.83e-06	3	49	2	23836061
Pubmed	Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation.	SIGLEC16 SIGLEC11	1.16e-05	4	49	2	17912374
Pubmed	Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.	SIGLEC16 SIGLEC11	1.16e-05	4	49	2	20038598
Pubmed	CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity.	SIGLEC16 SIGLEC11	1.16e-05	4	49	2	20200274
Pubmed	Siglec-G regulates B1 cell survival and selection.	SIGLEC16 SIGLEC11	1.16e-05	4	49	2	20729333
Pubmed	MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation.	IRAK1 MMP13	1.16e-05	4	49	2	17905570
Pubmed	Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction.	SIGLEC16 SIGLEC11	1.16e-05	4	49	2	30143587
Pubmed	Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.	SIGLEC16 SIGLEC11	1.16e-05	4	49	2	24695850
Pubmed	Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.	SIGLEC16 SIGLEC11	1.16e-05	4	49	2	25252961
Pubmed	Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.	SIGLEC16 SIGLEC11	1.16e-05	4	49	2	24600033
Pubmed	Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.	SIGLEC16 SIGLEC11	1.94e-05	5	49	2	36969253
Pubmed	CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.	SIGLEC16 SIGLEC11	1.94e-05	5	49	2	19264983
Pubmed	Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice.	SIGLEC16 SIGLEC11	1.94e-05	5	49	2	25987743
Pubmed	B Lymphocyte-Derived CCL7 Augments Neutrophil and Monocyte Recruitment, Exacerbating Acute Kidney Injury.	SIGLEC16 SIGLEC11	1.94e-05	5	49	2	32737150
Pubmed	The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation.	SIGLEC16 SIGLEC11	1.94e-05	5	49	2	27548433
Pubmed	Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells.	SIGLEC16 SIGLEC11	1.94e-05	5	49	2	26947073
Pubmed	A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.	SIGLEC16 SIGLEC11	1.94e-05	5	49	2	21623346
Pubmed	Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G).	SIGLEC16 SIGLEC11	2.91e-05	6	49	2	14559209
Pubmed	Genome-wide association study of suicide attempts in mood disorder patients.	IGSF5 SORBS1	2.91e-05	6	49	2	21041247
Pubmed	Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.	SIGLEC16 SIGLEC11	2.91e-05	6	49	2	11986327
Pubmed	Hand2 regulates chondrogenesis in vitro and in vivo.	MMP13 AXIN2	4.07e-05	7	49	2	19932774
Pubmed	Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair.	RUNX1 MMP13	4.07e-05	7	49	2	26923596
Pubmed	Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.	SIGLEC16 SIGLEC11	6.96e-05	9	49	2	23374343
Pubmed	Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.	SIGLEC9 SIGLEC11	8.69e-05	10	49	2	25320078
Pubmed	Runx1-Stat3-Tgfb3 signaling network regulating the anterior palatal development.	RUNX1 MMP13	1.06e-04	11	49	2	30046048
Pubmed	Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.	TMEM131 RUNX1	1.27e-04	12	49	2	27100087
Pubmed	Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis.	AAAS PKD1 BAZ1B	1.46e-04	72	49	3	33106477
Pubmed	Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid.	RUNX1 MMP13	1.50e-04	13	49	2	31171577
Pubmed	Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development.	MMP13 AXIN2	2.02e-04	15	49	2	28520221
Pubmed	The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.	SIGLEC16 SIGLEC11	2.02e-04	15	49	2	22496360
Pubmed	Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development.	MMP13 AXIN2	2.02e-04	15	49	2	23188710
Pubmed	Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm.	SELP ARL4A	2.30e-04	16	49	2	12781685
Pubmed	Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.	RUNX1 MMP13	2.61e-04	17	49	2	17199045
Pubmed	Cbfb regulates bone development by stabilizing Runx family proteins.	RUNX1 MMP13	2.61e-04	17	49	2	25262822
Pubmed	Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.	HIVEP3 RUNX1	2.93e-04	18	49	2	26091038
Pubmed	A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.	SELP BAZ1B	3.27e-04	19	49	2	19656773
Pubmed	Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.	MMP13 AXIN2	4.01e-04	21	49	2	34172578
Pubmed	Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.	PKD1 AXIN2	4.01e-04	21	49	2	16291790
Pubmed	Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary.	SOHLH1 AXIN2	4.41e-04	22	49	2	24899573
Pubmed	Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.	MMP13 AXIN2	4.83e-04	23	49	2	29981310
Pubmed	Dose-dependent effects of Runx2 on bone development.	RUNX1 MMP13	7.18e-04	28	49	2	19419310
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 HIVEP3 SEMA4F MEGF8 KALRN PKD1 IRAK1	8.59e-04	1105	49	7	35748872
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC9 SIGLEC16 SIGLEC11	1.60e-05	28	32	3	745
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	KALRN SIGLEC16 IGSF5 SIGLEC11	1.79e-04	161	32	4	593
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SIGLEC16 SIGLEC11	2.27e-03	40	32	2	592
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP PKD1	2.38e-03	41	32	2	1298
GeneFamily	Adenosine receptors\|V-set domain containing	SIGLEC9 SIGLEC16 SIGLEC11	2.94e-03	163	32	3	590
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	SELP PLXNC1 CD27 SIGLEC9	4.93e-03	394	32	4	471
GeneFamily	WD repeat domain containing	AAAS WDR6 WDR73	1.09e-02	262	32	3	362
ToppCell	VE-CD4-CD8_1\|VE / Condition, Cell_class and T cell subcluster	DNHD1 PATL2 CD27 SORBS1 HSDL1	2.44e-07	123	49	5	bc0f509716bb71d6e3fa343f4920ecb80eb62794
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	MTMR11 KALRN SBSPON SORBS1	2.95e-05	161	49	4	64891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARL4A USP43 RUNX1 GLP2R	3.73e-05	171	49	4	fdd96c6fe850bd10e1e0d0f18c4401f8348b7d2c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARL4A USP43 RUNX1 GLP2R	3.82e-05	172	49	4	4b693f2ccb0577da09cb78415e937f82f12b5458
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	MTMR11 KALRN SBSPON SORBS1	3.91e-05	173	49	4	a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCell	facs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE6 KALRN SBSPON KLHDC8B	4.27e-05	177	49	4	1b153fbfe1323dc589de4af73a52149ea5ce6763
ToppCell	facs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPNE6 KALRN SBSPON KLHDC8B	4.27e-05	177	49	4	32fecefba1a55e1f418c9a055236fa11175c692d
ToppCell	droplet-Fat-SCAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1 IGSF5 RUNX1 RPUSD1	5.29e-05	187	49	4	5fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCell	droplet-Fat-SCAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1 IGSF5 RUNX1 RPUSD1	5.29e-05	187	49	4	766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCell	droplet-Fat-SCAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1 IGSF5 RUNX1 RPUSD1	5.29e-05	187	49	4	f49d06600060deeb2fc1b1da5b93496535f20104
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	HIVEP3 PKD1 RUNX1 KLHDC8B	5.29e-05	187	49	4	816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLXNC1 SIGLEC9 SOHLH1 KLHDC8B	5.40e-05	188	49	4	fcf1bebef7aa81b4a11c1f9e4319339c290ecd22
ToppCell	facs-MAT-Fat-3m-Endothelial-endothelial_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 SELP SBSPON SORBS1	5.98e-05	193	49	4	e164f6403a8b541ced08a6feec915d2e855036ea
ToppCell	facs-MAT-Fat-3m-Endothelial\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 SELP SBSPON SORBS1	5.98e-05	193	49	4	b32533afeff1905e188becaa09079e9699722e4b
ToppCell	facs-MAT-Fat-3m-Endothelial-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCARF1 SELP SBSPON SORBS1	5.98e-05	193	49	4	2ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCell	Sepsis-URO-Lymphocyte-T/NK-Treg\|URO / Disease, condition lineage and cell class	SEMA4F KALRN CD27 AXIN2	6.35e-05	196	49	4	8812d7365fb2b33feff93782d60776e932499a43
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SBSPON IGSF5 SORBS1 ZNF692	6.60e-05	198	49	4	cbb63b255bdc92a557c5db1f08f7766ed9346607
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-dn_T\|ICU-SEP / Disease, condition lineage and cell class	KALRN CD27 PLEKHN1 KLHDC8B	6.86e-05	200	49	4	9ee3e18dc429b9c472e3e366d9bfdbb150daa369
Disease	alkaline phosphatase measurement	HIVEP3 AAAS SIGLEC9 PKD1 PRSS55 USP43 BAZ1B RUNX1	1.82e-04	1015	47	8	EFO_0004533
Disease	femoral neck bone geometry	HOOK2 RUNX1	2.23e-04	14	47	2	EFO_0004511
Disease	acute graft vs. host disease, donor genotype effect measurement	KALRN TMEM131	2.57e-04	15	47	2	EFO_0004599, EFO_0007892
Disease	hyperuricemia	BAZ1B SLC22A12	1.27e-03	33	47	2	EFO_0009104
Disease	urate measurement, bone density	ARL4A PLXNC1 PRSS55 RUNX1 GLP2R	2.96e-03	619	47	5	EFO_0003923, EFO_0004531
Disease	breast carcinoma	HIVEP3 ARL4A MTMR11 PLXNC1 ETFDH HOOK2	5.36e-03	1019	47	6	EFO_0000305
Disease	pulse pressure measurement	HIVEP3 MEGF8 PLXNC1 ETFDH PKD1 DELE1 SSPOP	6.17e-03	1392	47	7	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALCRWASSLHGSLFP	AAAS	116	Q9NRG9
RHLPCISLHPWLSSP	nan	231	Q9N2K0
ISLHPWLSSPCSSDS	nan	236	Q9N2K0
ARTLSTHWPPQRSLC	CD27	171	P26842
THWPPQRSLCSSDFI	CD27	176	P26842
SSLSSPLNPKLWCHV	BAZ1B	326	Q9UIG0
LSSSTPWHLQPTCAI	ARL4A	156	P40617
PDSPLTRWTKSLHSL	AXIN2	71	Q9Y2T1
LRSPTHYSSCRWPLL	DNHD1	3541	Q96M86
HYSSCRWPLLLDPSN	DNHD1	3546	Q96M86
NPSWEPFRLSLHSLC	CPNE6	201	O95741
AAPCSLLPRLRTWTS	NIPSNAP2	21	O75323
PSAPATLASRSLSHW	HNRNPDL	16	O14979
CPWRDSPSLLAVSSR	MTMR11	576	A4FU01
SLLTWLQTFHVPSPC	HOOK2	11	Q96ED9
IALPHCSLIFPATTW	PLXNC1	751	O60486
FLSWTHCRALPLPSG	MMP13	11	P45452
SCTSVILRWLPPSST	KALRN	2581	O60229
YSLHCPDRTWSLLAP	MEGF8	1706	Q7Z7M0
SAALRSWHLTPSCPL	IRAK1	596	P51617
LFCSLLTSWPPRFSH	PATL2	136	C9JE40
LPLCATRWSSTSTVP	ETFDH	26	Q16134
VTCLPSHWTRLPDIS	IGSF5	161	Q9NSI5
PWGTSPLSFHRKCSL	GLP2R	31	O95838
LRCIDSGHWSAPLPT	SELP	366	P16109
SHTWLALAPLPTARA	KLHDC8B	56	Q8IXV7
TAPSNFLHRCSWLVP	HSDL1	256	Q3SXM5
SAAVPSHRCWAPLLD	SLC22A12	41	Q96S37
RFFSSPLWHPCSSLR	DELE1	126	Q14154
LSTLCPAESWHLSPL	PKD1	4071	P98161
HLPAWDARPKALSTC	OR52E5	226	Q8NH55
DSPNFLCSVLPTHWR	RUNX1	66	Q01196
LPSLDACWSPHTLLQ	RPUSD1	231	Q9UJJ7
PHILASSRQWDPASC	SOHLH1	181	Q5JUK2
WDSGCLAPPSTRTSH	PLEKHN1	351	Q494U1
AHVVLPCSPSSAWAS	SEMA4F	581	O95754
PCTQHSLPWGLTLTL	SSPOP	4876	A2VEC9
TAFTPSHRCWVPLLD	SLC22A24	41	Q8N4F4
SLSWRGLTLCPSQPS	SIGLEC9	286	Q9Y336
LPCRSLSSHKLPWVT	SCARF1	481	Q14162
RGSLLSWSSAPCPSL	USP43	746	Q70EL4
SLTPHCALENWPLTR	SBSPON	176	Q8IVN8
HTWLDVCRLPATFPT	TEX52	96	A6NCN8
RASPSLSLSLPHLSW	SORBS1	1026	Q9BX66
LSLSLPHLSWSDRPT	SORBS1	1031	Q9BX66
TAELSWPSILSSPRH	TMEM131	821	Q92545
HKLLSRSPETCASPW	HIVEP3	2121	Q5T1R4
LPPSKQRWHTCSAFL	WDR6	486	Q9NNW5
GSPRSWLLLCPLSHV	PRSS55	331	Q6UWB4
HRASLSPTSASLPWA	VWA5B2	1096	Q8N398
CVTHSSPPARLSWTR	SIGLEC11	391	Q96RL6
THTWHPCRPRTLLSA	WDR73	346	Q6P4I2
PASLPHTTRRSWCSE	ZNF692	136	Q9BU19
LVCVTHSSPPARLSW	SIGLEC16	361	A6NMB1