Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glutathione hydrolase activity	GGTLC3 GGTLC1	3.05e-04	9	59	2	GO:0036374
GeneOntologyMolecularFunction	calcium ion binding	UNC13B FLG HSPG2 DCHS2 PPP2R3A CELSR1 HMCN2 CELSR3 FLG2	3.28e-04	749	59	9	GO:0005509
GeneOntologyCellularComponent	keratohyalin granule	FLG FLG2	8.06e-05	5	60	2	GO:0036457
Domain	Filaggrin	FLG FLG2	9.48e-06	2	58	2	IPR003303
Domain	WD40	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	1.50e-05	259	58	7	PF00400
Domain	WD40	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	1.86e-05	268	58	7	SM00320
Domain	WD40_repeat	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	2.05e-05	272	58	7	IPR001680
Domain	WD_REPEATS_1	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	2.36e-05	278	58	7	PS00678
Domain	WD_REPEATS_2	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	2.41e-05	279	58	7	PS50082
Domain	WD_REPEATS_REGION	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	2.41e-05	279	58	7	PS50294
Domain	DUF3446	EGR2 EGR3	2.84e-05	3	58	2	IPR021849
Domain	DUF3446	EGR2 EGR3	2.84e-05	3	58	2	PF11928
Domain	WD40_repeat_dom	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	3.60e-05	297	58	7	IPR017986
Domain	-	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	4.06e-05	679	58	10	3.30.160.60
Domain	zf-C2H2	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	4.83e-05	693	58	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	4.89e-05	694	58	10	IPR013087
Domain	zf-C2H2_6	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 ZNF184 ZNF69	5.12e-05	314	58	7	PF13912
Domain	-	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	7.41e-05	333	58	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	7.69e-05	335	58	7	IPR015943
Domain	EGF_LAM_2	HSPG2 CELSR1 CELSR3	1.09e-04	30	58	3	PS50027
Domain	EGF_LAM_1	HSPG2 CELSR1 CELSR3	1.09e-04	30	58	3	PS01248
Domain	KRAB	ZNF765 ZNF136 ZFP90 ZNF607 ZNF184 ZNF69 ZNF565	1.16e-04	358	58	7	PS50805
Domain	KRAB	ZNF765 ZNF136 ZFP90 ZNF607 ZNF184 ZNF69 ZNF565	1.16e-04	358	58	7	PF01352
Domain	ZINC_FINGER_C2H2_2	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	1.22e-04	775	58	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	1.25e-04	777	58	10	PS00028
Domain	KRAB	ZNF765 ZNF136 ZFP90 ZNF607 ZNF184 ZNF69 ZNF565	1.40e-04	369	58	7	SM00349
Domain	KRAB	ZNF765 ZNF136 ZFP90 ZNF607 ZNF184 ZNF69 ZNF565	1.43e-04	370	58	7	IPR001909
Domain	Znf_C2H2-like	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	1.52e-04	796	58	10	IPR015880
Domain	Znf_C2H2	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	1.67e-04	805	58	10	IPR007087
Domain	ZnF_C2H2	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	1.72e-04	808	58	10	SM00355
Domain	Laminin_EGF	HSPG2 CELSR1 CELSR3	1.73e-04	35	58	3	PF00053
Domain	EGF_Lam	HSPG2 CELSR1 CELSR3	1.73e-04	35	58	3	SM00180
Domain	LAM_G_DOMAIN	HSPG2 CELSR1 CELSR3	2.22e-04	38	58	3	PS50025
Domain	Laminin_EGF	HSPG2 CELSR1 CELSR3	2.22e-04	38	58	3	IPR002049
Domain	Laminin_G_2	HSPG2 CELSR1 CELSR3	2.59e-04	40	58	3	PF02210
Domain	LamG	HSPG2 CELSR1 CELSR3	3.44e-04	44	58	3	SM00282
Domain	Cadherin	DCHS2 CELSR1 CELSR3 FREM3	4.94e-04	118	58	4	IPR002126
Domain	GAIN_dom_N	CELSR1 CELSR3	5.12e-04	11	58	2	IPR032471
Domain	GAIN	CELSR1 CELSR3	5.12e-04	11	58	2	PF16489
Domain	EGF_CA	HSPG2 CELSR1 HMCN2 CELSR3	5.60e-04	122	58	4	SM00179
Domain	EGF-like_Ca-bd_dom	HSPG2 CELSR1 HMCN2 CELSR3	5.95e-04	124	58	4	IPR001881
Domain	Quinoprotein_ADH-like_supfam	GEMIN5 WDR90 EML3	5.96e-04	53	58	3	IPR011047
Domain	Laminin_G	HSPG2 CELSR1 CELSR3	7.77e-04	58	58	3	IPR001791
Domain	Growth_fac_rcpt_	HSPG2 CELSR1 HMCN2 PCSK4	1.40e-03	156	58	4	IPR009030
Domain	WD40_repeat_CS	GEMIN5 WDR90 CDC20 WDR59	1.68e-03	164	58	4	IPR019775
Domain	Apc4_WD40_dom	GEMIN5 CDC20	1.74e-03	20	58	2	IPR024977
Domain	ANAPC4_WD40	GEMIN5 CDC20	1.74e-03	20	58	2	PF12894
Domain	HormR	CELSR1 CELSR3	2.72e-03	25	58	2	SM00008
Domain	S100_CABP	FLG FLG2	3.16e-03	27	58	2	PS00303
Domain	S_100	FLG FLG2	3.16e-03	27	58	2	PF01023
Domain	-	HSPG2 CELSR1 CELSR3	3.21e-03	95	58	3	2.60.120.200
Domain	S100_Ca-bd_sub	FLG FLG2	3.40e-03	28	58	2	IPR013787
Domain	S100/CaBP-9k_CS	FLG FLG2	3.40e-03	28	58	2	IPR001751
Domain	HRM	CELSR1 CELSR3	3.40e-03	28	58	2	PF02793
Domain	S_100	FLG FLG2	3.40e-03	28	58	2	SM01394
Domain	ASX_HYDROXYL	CELSR1 HMCN2 CELSR3	3.71e-03	100	58	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CELSR1 HMCN2 CELSR3	4.37e-03	106	58	3	IPR000152
Domain	Cadherin_CS	DCHS2 CELSR1 CELSR3	4.73e-03	109	58	3	IPR020894
Domain	GPS	CELSR1 CELSR3	4.99e-03	34	58	2	SM00303
Domain	Cadherin	DCHS2 CELSR1 CELSR3	5.23e-03	113	58	3	PF00028
Domain	CADHERIN_1	DCHS2 CELSR1 CELSR3	5.23e-03	113	58	3	PS00232
Domain	GPS	CELSR1 CELSR3	5.28e-03	35	58	2	PF01825
Domain	CADHERIN_2	DCHS2 CELSR1 CELSR3	5.35e-03	114	58	3	PS50268
Domain	-	DCHS2 CELSR1 CELSR3	5.35e-03	114	58	3	2.60.40.60
Domain	CA	DCHS2 CELSR1 CELSR3	5.49e-03	115	58	3	SM00112
Domain	GPS	CELSR1 CELSR3	5.58e-03	36	58	2	PS50221
Domain	Cadherin-like	DCHS2 CELSR1 CELSR3	5.62e-03	116	58	3	IPR015919
Domain	GPS	CELSR1 CELSR3	5.89e-03	37	58	2	IPR000203
Domain	EGF_3	HSPG2 CELSR1 HMCN2 CELSR3	6.09e-03	235	58	4	PS50026
Domain	G_PROTEIN_RECEP_F2_1	CELSR1 CELSR3	6.85e-03	40	58	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	CELSR1 CELSR3	6.85e-03	40	58	2	PS50227
Domain	GPCR_2_extracellular_dom	CELSR1 CELSR3	6.85e-03	40	58	2	IPR001879
Domain	EGF	HSPG2 CELSR1 CELSR3	7.06e-03	126	58	3	PF00008
Domain	EGF-like_dom	HSPG2 CELSR1 HMCN2 CELSR3	7.45e-03	249	58	4	IPR000742
Domain	EGF_1	HSPG2 CELSR1 HMCN2 CELSR3	8.09e-03	255	58	4	PS00022
Domain	EGF-like_CS	HSPG2 CELSR1 HMCN2 CELSR3	8.76e-03	261	58	4	IPR013032
Domain	EGF_2	HSPG2 CELSR1 HMCN2 CELSR3	9.23e-03	265	58	4	PS01186
Pubmed	Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice.	CELSR1 CELSR3 EGR2	1.06e-06	12	60	3	20631168
Pubmed	The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes.	EGR3 FMN2	2.93e-06	2	60	2	24722338
Pubmed	EGR3 as a potential susceptibility gene for schizophrenia in Korea.	EGR2 EGR3	2.93e-06	2	60	2	20687139
Pubmed	The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells.	EGR2 EGR3	2.93e-06	2	60	2	23021953
Pubmed	The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.	CLK2 CLK3	2.93e-06	2	60	2	9637771
Pubmed	Egr-2 and Egr-3 are negative regulators of T cell activation.	EGR2 EGR3	2.93e-06	2	60	2	15834410
Pubmed	Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.	EGR2 EGR3	2.93e-06	2	60	2	29314730
Pubmed	Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.	EGR2 EGR3	2.93e-06	2	60	2	28487311
Pubmed	NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.	EGR2 EGR3	2.93e-06	2	60	2	23485457
Pubmed	Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.	EGR2 EGR3	2.93e-06	2	60	2	27856665
Pubmed	Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells.	EGR2 EGR3	2.93e-06	2	60	2	32709717
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	2.93e-06	2	60	2	24813994
Pubmed	Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.	EGR2 EGR3	2.93e-06	2	60	2	36342511
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG FLG2	8.77e-06	3	60	2	23403047
Pubmed	Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint.	EGR2 EGR3	8.77e-06	3	60	2	35045301
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	8.77e-06	3	60	2	28928464
Pubmed	Early growth response transcriptional regulators are dispensable for macrophage differentiation.	EGR2 EGR3	8.77e-06	3	60	2	17312150
Pubmed	The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.	CELSR1 CELSR3	8.77e-06	3	60	2	11677057
Pubmed	CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway.	DPP4 EGR2	8.77e-06	3	60	2	25548232
Pubmed	Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.	EGR2 EGR3	8.77e-06	3	60	2	15173177
Pubmed	Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.	EGR2 EGR3	8.77e-06	3	60	2	28455436
Pubmed	Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.	EGR2 EGR3	8.77e-06	3	60	2	27911796
Pubmed	Early Growth Response Genes 2 and 3 Regulate the Expression of Bcl6 and Differentiation of T Follicular Helper Cells.	EGR2 EGR3	8.77e-06	3	60	2	25979336
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	8.77e-06	3	60	2	32437351
Pubmed	Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1- CD4+ NKG2D+ T cells.	EGR2 EGR3	8.77e-06	3	60	2	33011290
Pubmed	Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.	EGR2 EGR3	8.77e-06	3	60	2	19706684
Pubmed	An amphioxus Krox gene: insights into vertebrate hindbrain evolution.	EGR2 EGR3	1.75e-05	4	60	2	11180801
Pubmed	Immediate early genes krox-24 and krox-20 are rapidly up-regulated after wounding in the embryonic and adult mouse.	EGR2 EGR3	1.75e-05	4	60	2	11891986
Pubmed	The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.	CELSR1 CELSR3	1.75e-05	4	60	2	37224017
Pubmed	Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.	CLK2 CLK3	1.75e-05	4	60	2	7990150
Pubmed	Chromosomal mapping of three human LAMMER protein-kinase-encoding genes.	CLK2 CLK3	1.75e-05	4	60	2	9856501
Pubmed	Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.	CLK2 CLK3	1.75e-05	4	60	2	9307018
Pubmed	Developmental expression profiles of Celsr (Flamingo) genes in the mouse.	CELSR1 CELSR3	1.75e-05	4	60	2	11850187
Pubmed	EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.	EGR2 EGR3	1.75e-05	4	60	2	20506119
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	UNC13B HSPG2 CELSR1 CELSR3 GEMIN5 PCNX1 WDR90 EML3 WDR59 AP3D1	1.79e-05	1105	60	10	35748872
Pubmed	Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.	EGR2 EGR3	2.92e-05	5	60	2	30012846
Pubmed	Integrated analysis of DNA methylation and RNA‑sequencing data in Down syndrome.	EGR2 EGR3	2.92e-05	5	60	2	27667480
Pubmed	Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells.	EGR2 EGR3	2.92e-05	5	60	2	29728568
Pubmed	The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.	EGR2 EGR3	2.92e-05	5	60	2	19169262
Pubmed	Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.	EGR2 EGR3	2.92e-05	5	60	2	18203138
Pubmed	[Expression of cell cycle molecules in human azoospermic testes].	CLK3 CDC20	2.92e-05	5	60	2	19426592
Pubmed	HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.	EGR2 EGR3	2.92e-05	5	60	2	11909874
Pubmed	Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.	CLK2 CLK3	2.92e-05	5	60	2	19168442
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	UNC13B AHI1 CLK2 CLK3 POLR2M AP3D1	3.58e-05	358	60	6	32460013
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	FLG FLG2	4.37e-05	6	60	2	27304082
Pubmed	Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system.	EGR2 EGR3	4.37e-05	6	60	2	37443284
Pubmed	Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses.	EGR2 EGR3	4.37e-05	6	60	2	14560009
Pubmed	No association between EGR gene family polymorphisms and schizophrenia in the Chinese population.	EGR2 EGR3	4.37e-05	6	60	2	20144677
Pubmed	Dystroglycan is a scaffold for extracellular axon guidance decisions.	CELSR1 CELSR3	4.37e-05	6	60	2	30758284
Pubmed	Early embryonic expression patterns of the mouse Flamingo and Prickle orthologues.	CELSR1 CELSR3	6.11e-05	7	60	2	17937400
Pubmed	Regulation of low affinity neurotrophin receptor (p75(NTR)) by early growth response (Egr) transcriptional regulators.	EGR2 EGR3	6.11e-05	7	60	2	17916431
Pubmed	Celsr1 suppresses Wnt5a-mediated chemoattraction to prevent incorrect rostral migration of facial branchiomotor neurons.	CELSR1 EGR2	6.11e-05	7	60	2	36325991
Pubmed	The atypical cadherin Celsr1 functions non-cell autonomously to block rostral migration of facial branchiomotor neurons in mice.	CELSR1 EGR2	1.05e-04	9	60	2	27395006
Pubmed	KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle.	PPP6R2 SEC13	1.31e-04	10	60	2	36995092
Pubmed	Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.	EGR2 EGR3	1.59e-04	11	60	2	23792428
Pubmed	A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.	WDR59 SEC13	1.59e-04	11	60	2	23723238
Pubmed	A dual role for planar cell polarity genes in ciliated cells.	CELSR1 CELSR3	1.59e-04	11	60	2	25024228
Pubmed	Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development.	CELSR1 CELSR3	1.91e-04	12	60	2	11891983
Pubmed	The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.	WDR59 SEC13	1.91e-04	12	60	2	25263562
Pubmed	EGR1 and EGR2 involvement in vertebrate tendon differentiation.	EGR2 EGR3	2.26e-04	13	60	2	21173153
Pubmed	Structure of the nutrient-sensing hub GATOR2.	WDR59 SEC13	2.26e-04	13	60	2	35831510
Pubmed	A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea.	CELSR1 CELSR3	2.63e-04	14	60	2	29784671
Pubmed	Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.	CELSR1 CELSR3	2.63e-04	14	60	2	39225402
Pubmed	The human gamma-glutamyltransferase gene family.	GGTLC3 GGTLC1	2.63e-04	14	60	2	18357469
Pubmed	CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.	FLG FLG2 SEC13	2.67e-04	72	60	3	36123327
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCAPD3 ZFP90 CELSR3 PLPPR4 PCNX1 WDR90	3.01e-04	529	60	6	14621295
Pubmed	Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.	CELSR1 CELSR3	3.03e-04	15	60	2	20473291
Pubmed	Ring domains are essential for GATOR2-dependent mTORC1 activation.	WDR59 SEC13	3.03e-04	15	60	2	36528027
Pubmed	SZT2 dictates GATOR control of mTORC1 signalling.	WDR59 SEC13	3.46e-04	16	60	2	28199315
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	HSPG2 FREM3	3.46e-04	16	60	2	15878328
Pubmed	Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.	EGR2 EGR3	4.40e-04	18	60	2	9858769
Pubmed	KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.	WDR59 SEC13	5.45e-04	20	60	2	28199306
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	FLG FLG2	6.02e-04	21	60	2	19601998
Pubmed	Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.	CELSR1 EGR2	6.02e-04	21	60	2	18701545
Pubmed	Schwann cell myelination requires integration of laminin activities.	HSPG2 EGR2	6.02e-04	21	60	2	22767514
Pubmed	The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.	CELSR1 GGTLC1 FREM3	6.04e-04	95	60	3	20843830
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	EGR2 EGR3 TNS2 CDC20	6.47e-04	227	60	4	26410627
Pubmed	The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification.	ZNF765 ZNF136	6.61e-04	22	60	2	31403225
Pubmed	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	EGR2 EGR3	7.23e-04	23	60	2	20379146
Pubmed	An unappreciated role for RNA surveillance.	CLK2 CLK3 CSNK1G1	7.42e-04	102	60	3	14759258
Pubmed	Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.	ZNF184 CDC20	7.88e-04	24	60	2	25043184
Pubmed	Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.	HSPG2 EGR2	8.56e-04	25	60	2	19056886
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	UNC13B NDRG3 EML3	9.24e-04	110	60	3	27889896
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	CELSR1 CELSR3	9.26e-04	26	60	2	37228654
Pubmed	Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain.	CELSR3 EGR2	9.99e-04	27	60	2	19208226
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	HSPG2 GGTLC3 CLK2 SEC13	1.03e-03	257	60	4	30945288
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CA12 ZNF765 NCAPD3 ZFP90 ZNF184 GEMIN5 CDC20 AP3D1	1.04e-03	1203	60	8	29180619
Pubmed	Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.	DPP4 GGTLC1	1.15e-03	29	60	2	22424930
Pubmed	Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.	NFE2L3 PCNX1	1.32e-03	31	60	2	27321927
Pubmed	Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.	UNC13B AHI1	1.32e-03	31	60	2	25838543
Pubmed	Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.	CELSR1 CELSR3	1.40e-03	32	60	2	23177622
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	AHI1 CHGB NDRG3	1.43e-03	128	60	3	30995482
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	PCNX1 CDC20	1.49e-03	33	60	2	19336002
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	CELSR1 CELSR3	1.49e-03	33	60	2	25713288
Pubmed	The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.	WDR59 SEC13	1.49e-03	33	60	2	33452816
Pubmed	Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints.	PCSK4 AP3D1	1.68e-03	35	60	2	10984455
Cytoband	15q24	CLK3 CEMIP	3.59e-04	21	61	2	15q24
GeneFamily	WD repeat domain containing	AHI1 GEMIN5 WDR90 CDC20 EML3 WDR59 SEC13	4.09e-06	262	46	7	362
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF765 ZNF136 ZFP90 ZSCAN22 ZNF607 EGR2 EGR3 ZNF184 ZNF69 ZNF565	1.02e-05	718	46	10	28
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3	1.90e-05	3	46	2	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR3	1.90e-05	3	46	2	1189
GeneFamily	CDC like kinases	CLK2 CLK3	3.79e-05	4	46	2	480
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG FLG2	1.32e-04	7	46	2	1350
GeneFamily	CD molecules\|Gamma-glutamyltransferases	GGTLC3 GGTLC1	4.85e-04	13	46	2	564
GeneFamily	EF-hand domain containing	FLG PPP2R3A FLG2	1.82e-02	219	46	3	863
GeneFamily	SH2 domain containing	TNS2 SH2D7	2.73e-02	101	46	2	741
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELSR3 EGR2 EGR3 LRRC53 CHGB	5.21e-06	183	61	5	49f3ddc1c7c04b4ca837dbd6dad995add82941d6
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B AHI1 ZNF184 CHGB TUFT1	5.64e-06	186	61	5	f5468e03321ea2083e223eb0d92c3a9307039569
Disease	aflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)	GGTLC3 GGTLC1	8.48e-05	7	60	2	DOID:5022 (biomarker_via_orthology)
Disease	alcohol dependence (biomarker_via_orthology)	GGTLC3 GGTLC1	1.13e-04	8	60	2	DOID:0050741 (biomarker_via_orthology)
Disease	cystatin-D measurement	CA12 GGTLC1	5.42e-04	17	60	2	EFO_0008103
Disease	selective IgA deficiency disease	AHI1 EGR2	3.97e-03	46	60	2	EFO_1001929

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASQVGEITGTHHHTR	nan	21	Q8N976
RVAEHHVATLSGHSQ	CDC20	296	Q12834
VHCERHHESSSVDTE	AHI1	561	Q8N157
ATFDHEHHSTIVSTR	CLK2	331	P49760
TGAITHHGHHTDVVR	ARMC6	226	Q6NXE6
SATFDHEHHTTIVAT	CLK3	471	P49761
AVTASDGTRSHTAHV	CELSR1	761	Q9NYQ6
VSTHEQSESAHGRTR	FLG	1121	P20930
SRHHEASTHADISRH	FLG	2856	P20930
SGDSSRHSVSRHHEA	FLG	3171	P20930
RHSVSRHHEASTHAD	FLG	3176	P20930
RHHEASTHADISRHS	FLG	3181	P20930
SIHHTFSRCVTVHGS	CEMIP	581	Q8WUJ3
SEHGSSKHTVAEHTS	ACRV1	71	P26436
SKHTVAEHTSGEHAE	ACRV1	76	P26436
AEHTSGEHAESEHAS	ACRV1	81	P26436
HHHFSVVERVDSCAS	AP3D1	1091	O14617
VTHATSHGRAHSVEE	HSPG2	716	P98160
RSDHLTTHIRTHTGE	EGR2	381	P11161
QEHDIETTHGVVHVT	NDRG3	31	Q9UGV2
SDSEVHSKVSHRHSE	FLG2	1276	Q5D862
QHGESESTVHERHET	FLG2	1376	Q5D862
HGESESIVHERHGTI	FLG2	1756	Q5D862
VDVSHHSTVDSSHLH	LYSMD3	246	Q7Z3D4
HGVTHDHEDSNESLS	GABRQ	491	Q9UN88
EAHSGVSSIHSSIRH	HMCN2	4421	Q8NDA2
TDAEHRHSHSQFSTE	LRRC53	846	A6NM62
HVDSGASAITRESHT	CSNK1G1	341	Q9HCP0
SEHTVSGQHFAAELH	CA12	131	O43570
ERGTDSEHTHKAHLV	PCNX1	651	Q96RV3
IVTTDLHHGCTDQHT	PCSK4	356	Q6UW60
ELSAVHSSHHEIGVN	DDIAS	321	Q8IXT1
DQEVTAALETRHHHT	GGTLC1	176	Q9BX51
TDHESSSHHDLEGAV	NFE2L3	451	Q9Y4A8
TDEDHGIASSTAHQH	DPP4	736	P27487
HTFTHGIDCIVVHHS	PPP2R3A	36	Q06190
DQAVTAALETRHHHT	GGTLC3	176	B5MD39
AALETRHHHTQIAST	GGTLC3	181	B5MD39
DVTVGSLVHHITAHD	DCHS2	1631	Q6V1P9
RSDHLTTHIRTHTGE	EGR3	316	Q06889
HGTEKISTARSEGHH	DEFB112	31	Q30KQ8
DVTLVVGTHGHSDHI	MBLAC1	106	A4D2B0
HVTSVRFTHDDSHLV	EML3	841	Q32P44
LVRHGSAADHTDHSL	CELSR3	2856	Q9NYQ7
SEASEHHPRHRVSSQ	POLR2M	166	P0CAP2
HHPRHRVSSQAEDTS	POLR2M	171	P0CAP2
TLTHTHTHRDTHTAS	FAM27D1	116	Q5T7N8
HSISTEFQTSHEHSV	FMN2	831	Q9NZ56
RSETHAAGHSQEKTH	CHGB	216	P05060
TVDLVSTHHLHSSSE	PPP6R2	531	O75170
VCTAFTAEHATHGHV	FADS6	126	Q8N9I5
TSDTFHLEVSDGVHH	FREM3	911	P0C091
SHEHAGHDSSVNSVC	SEC13	96	P55735
HLERHDSVFVAAHTS	SKIV2L	321	Q15477
ITAATHVHEASSRSH	STARD9	211	Q9P2P6
HVHEASSRSHAIFTI	STARD9	216	Q9P2P6
IRHHSHFHSGDDSQV	NCAPD3	651	P42695
DSNEHHHHGITTIRV	PLPPR4	691	Q7Z2D5
HSLASELVESHDGHE	TUFT1	61	Q9NNX1
HTAAAGTHVLTHESA	WDR90	326	Q96KV7
HSSEVTRHQRIHSGE	ZNF565	386	Q8N9K5
SHHSFRTHEIIHTGE	ZNF136	151	P52737
VGHTERVSGFTFSHH	GEMIN5	61	Q8TEQ6
SSHELSIHHRVHTGE	ZNF607	656	Q96SK3
GDTQSHSTLAELVHH	SH2D7	111	A6NKC9
DHRETDSIHSCHSSH	UNC13B	286	O14795
TEDTDHQHTASHGEE	WDR59	351	Q6PJI9
ESSHDHIAHSEAARL	ZSCAN22	36	P10073
SHERTQTHVRIHSGE	ZNF69	461	Q9UC07
REVFHAGTSQRHESH	ZNF765	66	Q7L2R6
SAHIVAHAAVASGRH	TTC23	271	Q5W5X9
QHHEDSVDGSLTHTR	TNS2	461	Q63HR2
RSTHLTEHQNTHTGE	ZNF184	681	Q99676
SFRHGTSLTQHEVTH	ZFP90	346	Q8TF47
HITDFTDHQRIHTAE	ZFP90	461	Q8TF47