Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbon-sulfur lyase activity	CENPVL2 CENPVL3 CENPVL1	1.55e-05	16	62	3	GO:0016846
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	3.52e-08	12	56	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	3.52e-08	12	56	4	IPR027970
Domain	2pore_dom_K_chnl	KCNK10 KCNK12	9.04e-04	15	56	2	IPR003280
Domain	K_chnl_dom	KCNK10 KCNK12	1.79e-03	21	56	2	IPR013099
Domain	Ion_trans_2	KCNK10 KCNK12	1.79e-03	21	56	2	PF07885
Domain	Ricin_B_lectin	GALNT2 GALNT13	2.53e-03	25	56	2	PF00652
Domain	RICIN	GALNT2 GALNT13	3.17e-03	28	56	2	SM00458
Domain	RICIN_B_LECTIN	GALNT2 GALNT13	3.17e-03	28	56	2	PS50231
Domain	Ricin_B_lectin	GALNT2 GALNT13	3.64e-03	30	56	2	IPR000772
Domain	Glycos_transf_2	GALNT2 GALNT13	3.64e-03	30	56	2	PF00535
Domain	Glyco_trans_2-like	GALNT2 GALNT13	3.64e-03	30	56	2	IPR001173
Domain	PH	TIAM1 KIF1A SPATA13 MPRIP	4.91e-03	229	56	4	PF00169
Domain	bHLH_dom	ATOH7 FERD3L SIRT7	5.34e-03	118	56	3	IPR011598
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.36e-13	6	67	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.36e-13	6	67	5	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	9.41e-10	24	67	5	32212159
Pubmed	Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.	CENPVL2 CENPVL3 CENPVL1	1.36e-07	6	67	3	27250503
Pubmed	Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication.	AKAP8 MCM2	1.10e-05	3	67	2	12740381
Pubmed	A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.	MCM2 PRKDC	2.19e-05	4	67	2	19058849
Pubmed	Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation.	CXCR3 PRKDC	2.19e-05	4	67	2	22392992
Pubmed	Gene expression of TWEAK/Fn14 and IP-10/CXCR3 in glomerulus and tubulointerstitium of patients with lupus nephritis.	CXCR3 TNFSF12	2.19e-05	4	67	2	21303425
Pubmed	MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.	PRKDC PTGER4	2.19e-05	4	67	2	15265935
Pubmed	FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells.	CXCR3 PRKDC	2.19e-05	4	67	2	36759517
Pubmed	Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.	CXCR3 PRKDC	2.19e-05	4	67	2	26831100
Pubmed	Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family.	GALNT2 GALNT13	3.64e-05	5	67	2	12651884
Pubmed	UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity.	UBR5 MCM2	5.46e-05	6	67	2	31586398
Pubmed	Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina.	ATOH7 L3MBTL3	5.46e-05	6	67	2	29977079
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	JAG2 AMPD2 ESYT2 GALNT2 AKAP8 KIF1A UBR5 TCF25 PRKDC	7.91e-05	942	67	9	31073040
Pubmed	A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.	TIAM1 UBR5 PRKDC	1.67e-04	55	67	3	34237211
Pubmed	MRE11 complex links RECQ5 helicase to sites of DNA damage.	UBR5 PRKDC	1.99e-04	11	67	2	19270065
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SMG8 ERCC3 AKAP8 UBR5 MCM2 MPRIP	2.06e-04	440	67	6	34244565
Pubmed	Potassium leak channels and the KCNK family of two-P-domain subunits.	KCNK10 KCNK12	2.38e-04	12	67	2	11256078
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	ZC3H13 TCF25 MCM2 PRKDC PIWIL3 MPRIP	3.17e-04	477	67	6	31300519
Pubmed	Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human.	GALR3 MPRIP	3.28e-04	14	67	2	10384052
Pubmed	Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.	SMG8 GALNT2	3.28e-04	14	67	2	23620142
Pubmed	Identification of potential protein interactors of Lrrk2.	AKAP8 PRKDC	3.78e-04	15	67	2	17400507
Pubmed	The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression.	PKN1 PRKDC MPRIP	4.02e-04	74	67	3	35102251
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	AMPD2 AKAP8 UBR5 ZNRD2 PKN1 SPATA13 MTSS2 MPRIP	5.16e-04	963	67	8	28671696
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	ERCC3 GALNT2 AKAP8 UBR5 ZNRD2 TCF25 PBXIP1	6.16e-04	754	67	7	33060197
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK5 TIAM1 PRKDC MPRIP	6.36e-04	202	67	4	33005030
Pubmed	Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis.	ATOH7 HS6ST1	6.79e-04	20	67	2	24753163
Pubmed	A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus.	MCM2 PRKDC	7.50e-04	21	67	2	20808282
Pubmed	Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.	ZNRD2 ATOH7	8.24e-04	22	67	2	25241763
Pubmed	p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.	SPATA31A3 PRKDC	8.24e-04	22	67	2	25331947
Pubmed	Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.	GALNT2 GALNT13	8.24e-04	22	67	2	25107907
Pubmed	A "double adaptor" method for improved shotgun library construction.	TIAM1 KIF1A ALDH16A1 KCNK10 TXNDC11 C2orf72	8.38e-04	574	67	6	8619474
Pubmed	Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development.	JAG2 ATOH7	9.01e-04	23	67	2	19191219
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	UBR5 ZC3H13 MPRIP	9.67e-04	100	67	3	10048485
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT2 GALNT13	9.82e-04	24	67	2	31882545
Pubmed	OTUB1 modulates c-IAP1 stability to regulate signalling pathways.	UBR5 TNFSF12	9.82e-04	24	67	2	23524849
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT2 GALNT13	9.82e-04	24	67	2	31740596
Pubmed	Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.	JAG2 ATOH7	1.24e-03	27	67	2	24148613
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	AMPD2 ESYT2 AKAP8 TIAM1 SPATA13 MTSS2 MPRIP	1.33e-03	861	67	7	36931259
Pubmed	Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells.	CXCR3 PRKDC	1.44e-03	29	67	2	34678150
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	SMG8 PRKDC	1.44e-03	29	67	2	20371770
Pubmed	Genome-wide association study of smoking behaviours in patients with COPD.	SOCS5 SLC24A3	1.44e-03	29	67	2	21685187
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	UBR5 PRKDC	1.54e-03	30	67	2	32867711
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	JAG2 TXNDC11 MPRIP	1.56e-03	118	67	3	21078624
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DOCK5 SMG8 GALNT2 TCF25 PBXIP1 PLXNB1	1.58e-03	650	67	6	38777146
Pubmed	Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.	KIF1A ATOH7 PANO1	1.63e-03	120	67	3	21697133
Pubmed	Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.	ERCC3 PRKDC	1.64e-03	31	67	2	20813000
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	DOCK5 SOCS5 PRKDC	1.67e-03	121	67	3	31900314
Pubmed	Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.	ESYT2 PRKDC MPRIP	1.79e-03	124	67	3	35516420
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	6.02e-05	8	68	2	chr9q12
Cytoband	Xp11.22	CENPVL2 CENPVL3 CENPVL1	7.30e-05	54	68	3	Xp11.22
Cytoband	2q21	ERCC3 HS6ST1	1.94e-04	14	68	2	2q21
Cytoband	Ensembl 112 genes in cytogenetic band chrXp11	CENPVL2 CENPVL3 MAGEH1 H2AL3 CENPVL1	2.48e-04	377	68	5	chrXp11
Cytoband	9p13.1	SPATA31A1 SPATA31A3	5.84e-04	24	68	2	9p13.1
Cytoband	9p11.2	SPATA31A6 FAM27D1	9.15e-04	30	68	2	9p11.2
Cytoband	17q22	SMG8 MKS1	1.96e-03	44	68	2	17q22
Cytoband	19p13.12	DCAF15 PKN1	2.53e-03	50	68	2	19p13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr2q23	EPC2 GALNT13	2.84e-03	53	68	2	chr2q23
GeneFamily	Potassium two pore domain channel subfamily K	KCNK10 KCNK12	4.21e-04	15	37	2	277
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT2 GALNT13	7.56e-04	20	37	2	433
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TIAM1 KIF1A SPATA13 MPRIP	8.05e-04	206	37	4	682
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TIAM1 SPATA13	8.05e-03	66	37	2	722
GeneFamily	Basic helix-loop-helix proteins	ATOH7 FERD3L	2.13e-02	110	37	2	420
ToppCell	COVID-CD4-CD4_Treg\|COVID / Condition, Cell_class and T cell subcluster	AMPD2 RTL5 KCNK12 PTGER4 L3MBTL3	4.51e-06	159	68	5	037cd97c41eb2f91fd3f69bbb3ffdfd6c0158410
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	KIF1A RTL5 KCNK10 CPE KCNK12	7.19e-06	175	68	5	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	KIF1A RTL5 KCNK10 CPE KCNK12	7.19e-06	175	68	5	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	COPD-Epithelial-PNEC\|Epithelial / Disease state, Lineage and Cell class	KIF1A KCNK10 CPE KCNK12 GALNT13	8.02e-06	179	68	5	988d0853c391da1e5004f73f3678047418d3f6d3
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF1A KCNK10 CPE KCNK12 GALNT13	9.17e-06	184	68	5	d5e44c9085da2a46531ed6db1249bdd88c41b45c
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF1A KCNK10 CPE KCNK12 GALNT13	9.41e-06	185	68	5	a34663974868e267495240c0d5c06e390f57b08b
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF1A KCNK10 CPE KCNK12 GALNT13	9.41e-06	185	68	5	b52e6adfecac93210c27c1d321a5951d54846c40
ToppCell	3'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF1A KCNK10 CPE KCNK12 GALNT13	9.41e-06	185	68	5	522030941687a268ec2520248df1817b57744a19
Computational	Genes in the cancer module 486.	JAG2 KIF1A PLXNB1 MPRIP	1.83e-04	100	31	4	MODULE_486
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; HL60; HT_HG-U133A	DCAF15 MAGEH1 SLC24A3 PBXIP1 MTSS2 C2orf72	1.02e-05	195	58	6	2386_UP
Drug	Corynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	RPH3AL TIAM1 KIF1A PBXIP1 PLXNB1 MTSS2	1.05e-05	196	58	6	4227_DN
Disease	renal sinus adipose tissue measurement	TIAM1 L3MBTL3	2.82e-04	13	57	2	EFO_0004864
Disease	myocarditis (implicated_via_orthology)	CXCR3 PTGER4	3.29e-04	14	57	2	DOID:820 (implicated_via_orthology)
Disease	albumin:globulin ratio measurement	GALNT2 TNFSF12 MPRIP	3.86e-04	73	57	3	EFO_0005128
Disease	nicotine dependence symptom count, depressive symptom measurement	KCNK10 SLC24A3 GALNT13	4.18e-04	75	57	3	EFO_0007006, EFO_0009262
Disease	dilated cardiomyopathy (implicated_via_orthology)	JAG2 CXCR3 PTGER4	5.05e-04	80	57	3	DOID:12930 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	UBR5 PKN1 PRKDC	8.60e-04	96	57	3	C1319315
Disease	obsolete Mendelian syndromes with cleft lip/palate	PKN1 SPATA13	9.04e-04	23	57	2	MONDO_0015335
Disease	myeloperoxidase measurement	SMG8 GALNT2	1.16e-03	26	57	2	EFO_0005243
Disease	Squamous cell carcinoma	ERCC3 TIAM1 PRKDC	1.80e-03	124	57	3	C0007137
Disease	lysophosphatidylethanolamine 18:1 measurement	SLC24A3 GALNT13	1.98e-03	34	57	2	EFO_0010368
Disease	age at menopause	ESYT2 TCF25 PRKDC GALNT13	2.77e-03	302	57	4	EFO_0004704

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLLVSRGQRRLRAMR	CXCR3	241	P49682
RLGARRRAKTARGLR	ESYT2	56	A0FGR8
RRRIGRGGRVIMDRI	EPC2	451	Q52LR7
GRDDRGRLYRRTLMR	BEST2	116	Q8NFU1
PRRRLREMLRDVRGR	C2orf72	121	A6NCS6
REMLRDVRGRRRAGA	C2orf72	126	A6NCS6
RRLQERMGRLRSGRG	ALDH16A1	321	Q8IZ83
MRRLRHREVRGPVLG	B3GALT5-AS1	1	P59052
RMRDRDRPKRRGFDR	AKAP8	281	O43823
MRPARRRGGRRQLLL	C20orf204	151	A0A1B0GTL2
VVMGGRRRRRRRRRR	H2AL3	131	A0A3B3IU63
MGRVRNRATAQRRRR	CENPVL1	1	A0A0U1RR11
MRNRGQGLFRLRSRC	AMPD2	1	Q01433
RILRGSQRARRKRRG	L3MBTL3	201	Q96JM7
AMRQRDREAGRGLGR	MCM2	116	P49736
EQLRRRLARARRTAM	INKA1	231	Q96EL1
ARRREERRKRFGMLD	MPRIP	586	Q6WCQ1
MPRGRKSRRRRNARA	MAGEH1	1	Q9H213
MEAARRPRLGLSRRR	FAAP20	1	Q6NZ36
MRAQGRGRLPRRLLL	JAG2	1	Q9Y219
LRNDRREGLMRSRVR	GALNT2	196	Q10471
AMSERLRPRKRRRNG	FAM104A	66	Q969W3
SRMLQPSQGLGRRRR	PLXNB1	1291	O43157
MRACRERQLRRSGLL	KCNK12	176	Q9HB15
EDMLVAIRRGVRLRR	MTSS2	721	Q765P7
RRRSFRRIAGAEIQM	PTGER4	256	P35408
RDLCRQILFRRMRGR	CSNKA2IP	446	A0A1B0GTH6
TIRSMERRRLGLDQR	KCNK10	371	P57789
MRRRRAGGRTMVERA	HS6ST1	1	O60243
MRPSGDEDRARRRRR	SLC24A3	1	Q9HC58
RMEERSGLIRARLRG	GALNT13	181	Q8IUC8
TRMCGERARNRRGRA	PANO1	121	I0J062
RRRATGRAGRAMLAV	GALR3	226	O60755
RLLRRINRTVIGMNR	DOCK5	931	Q9H7D0
MGRVRNRATAQRRRR	CENPVL2	1	P0DPI3
LREGRPRRMARFEEG	FERD3L	46	Q96RJ6
MGRVRNRATAQRRRR	CENPVL3	1	A0A0U1RRI6
RRLAANARERRRMQG	ATOH7	41	Q8N100
RRMQGLNTAFDRLRR	ATOH7	51	Q8N100
GMRRRRRLQQEDGIS	CPE	36	P16870
EKYRRRGNGTRLIMR	GLYATL1B	236	A0A0U1RQE8
RRLGMQGPLEALRRR	HEPN1	21	Q6WQI6
GSRRQEAQRLGRVLR	ERCC3	631	P19447
MRLQLLRDRRISSRG	FAM27D1	11	Q5T7N8
MPGRARTRARGRARR	PIWIL3	1	Q7Z3Z3
QLRGTRQRMRRESRT	PKD1L1	2266	Q8TDX9
DLRGRNLRPMRERTA	DCAF15	421	Q66K64
GSPGMQRRRRRVLDT	KIF1A	1336	Q12756
QRIGRLVERLETMRR	RPH3AL	71	Q9UNE2
VVMGRGRRRDDIARA	SMG8	831	Q8ND04
LIRRTGRLGQRQVRR	RTL5	531	Q5HYW3
KFGRTRSGLQRRERR	SOCS5	141	O75159
VGRRRRPRGRMKNHS	SPATA31A6	66	Q5VVP1
ERARQGRLRATFMRE	IQCA1L	171	A6NCM1
RMSARNRCRGKRVRQ	HMGB4	171	Q8WW32
VGRRRRPRGRMKNHS	SPATA31A7	66	Q8IWB4
MRRLLRRNPERRLGS	PKN1	846	Q16512
LQGRSRRREGLKRRQ	SIRT7	61	Q9NRC8
IGLDRVGRRRQMRAS	SPATA13	81	Q96N96
VGRRRRPRGRMKNHS	SPATA31A3	66	Q5VYP0
KSLGRRRRRLARNRF	TIAM1	1441	Q13009
NVRRRRQDRRGMEGG	MKS1	161	Q9NXB0
DTDVDMEGLRRRRGR	PBXIP1	151	Q96AQ6
VGRRRRPRGRMKNHS	SPATA31A1	66	Q5TZJ5
VGRRRRPRGRMKNHS	SPATA31A5	66	Q5VU36
GRTDLLRLRRRFMRD	PRKDC	2721	P78527
ARRERQDRISRLMGD	ZNRD2	26	O60232
GRLRRGLRGAFLMAR	TXNDC11	46	Q6PKC3
MAARRSQRRRGRRGE	TNFSF12	1	O43508
MSRRALRRLRGEQRG	TCF25	1	Q9BQ70
RNDRMGRSRGRVPEL	ZC3H13	556	Q5T200
LMQRLRNRGERDRER	UBR5	2326	O95071
EREREMRRSSGLRAG	UBR5	2341	O95071
MRRSSGLRAGSRRDR	UBR5	2346	O95071