Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	PMS2P1 RHOH ATP5PO ATP7B MYO19 GBP1 MACF1 GBP3 RAD54L	3.69e-04	775	58	9	GO:0017111
GeneOntologyMolecularFunction	GDP phosphatase activity	GBP1 GBP3	5.37e-04	12	58	2	GO:0004382
GeneOntologyMolecularFunction	pyrophosphatase activity	PMS2P1 RHOH ATP5PO ATP7B MYO19 GBP1 MACF1 GBP3 RAD54L	6.55e-04	839	58	9	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	PMS2P1 RHOH ATP5PO ATP7B MYO19 GBP1 MACF1 GBP3 RAD54L	6.61e-04	840	58	9	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	PMS2P1 RHOH ATP5PO ATP7B MYO19 GBP1 MACF1 GBP3 RAD54L	6.61e-04	840	58	9	GO:0016818
GeneOntologyCellularComponent	host cell part	GBP1 GBP3	1.13e-04	6	58	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP1 GBP3	1.13e-04	6	58	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP1 GBP3	1.13e-04	6	58	2	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP1 GBP3	1.13e-04	6	58	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP1 GBP3	1.13e-04	6	58	2	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP1 GBP3	1.13e-04	6	58	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP1 GBP3	1.13e-04	6	58	2	GO:0030430
GeneOntologyCellularComponent	symbiont cell surface	GBP1 GBP3	2.10e-04	8	58	2	GO:0106139
GeneOntologyCellularComponent	other organism part	GBP1 GBP3	2.69e-04	9	58	2	GO:0044217
GeneOntologyCellularComponent	host cellular component	GBP1 GBP3	7.76e-04	15	58	2	GO:0018995
Domain	-	AMT PDPR	4.90e-05	4	54	2	2.40.30.110
Domain	GcvT/YgfZ_C	AMT PDPR	4.90e-05	4	54	2	IPR029043
Domain	GCV_T_C	AMT PDPR	8.16e-05	5	54	2	IPR013977
Domain	GCV_T_C	AMT PDPR	8.16e-05	5	54	2	PF08669
Domain	GCV_T	AMT PDPR	8.16e-05	5	54	2	PF01571
Domain	GCV_T_N	AMT PDPR	8.16e-05	5	54	2	IPR006222
Domain	-	AMT PDPR	8.16e-05	5	54	2	3.30.1360.120
Domain	TrmE/GcvT_dom1	AMT PDPR	8.16e-05	5	54	2	IPR027266
Domain	-	DCDC1 RP1	1.71e-04	7	54	2	3.10.20.230
Domain	DC	DCDC1 RP1	2.27e-04	8	54	2	PS50309
Domain	Doublecortin_dom	DCDC1 RP1	2.27e-04	8	54	2	IPR003533
Domain	GBP_C	GBP1 GBP3	3.64e-04	10	54	2	PF02841
Domain	G_GB1_RHD3_dom	GBP1 GBP3	4.44e-04	11	54	2	IPR030386
Domain	Guanylate-bd_C	GBP1 GBP3	4.44e-04	11	54	2	IPR003191
Domain	GBP	GBP1 GBP3	4.44e-04	11	54	2	PF02263
Domain	Guanylate-bd_N	GBP1 GBP3	4.44e-04	11	54	2	IPR015894
Domain	G_GB1_RHD3	GBP1 GBP3	4.44e-04	11	54	2	PS51715
Domain	Actinin_actin-bd_CS	SYNE1 MACF1	2.00e-03	23	54	2	IPR001589
Domain	Spectrin	SYNE1 MACF1	2.00e-03	23	54	2	PF00435
Domain	ACTININ_2	SYNE1 MACF1	2.00e-03	23	54	2	PS00020
Domain	ACTININ_1	SYNE1 MACF1	2.00e-03	23	54	2	PS00019
Domain	Spectrin_repeat	SYNE1 MACF1	3.17e-03	29	54	2	IPR002017
Domain	Spectrin/alpha-actinin	SYNE1 MACF1	3.85e-03	32	54	2	IPR018159
Domain	SPEC	SYNE1 MACF1	3.85e-03	32	54	2	SM00150
Domain	WD40	PLAA CFAP52 STRAP WDR6	6.64e-03	259	54	4	PF00400
Domain	WD40	PLAA CFAP52 STRAP WDR6	7.47e-03	268	54	4	SM00320
Domain	Znf_C2H2-like	ZBTB38 ATXN7 ZNF875 GLI2 ZNF778 ZNF443 CASZ1	7.70e-03	796	54	7	IPR015880
Domain	WD40_repeat	PLAA CFAP52 STRAP WDR6	7.86e-03	272	54	4	IPR001680
Domain	Znf_C2H2	ZBTB38 ATXN7 ZNF875 GLI2 ZNF778 ZNF443 CASZ1	8.17e-03	805	54	7	IPR007087
Domain	ZnF_C2H2	ZBTB38 ATXN7 ZNF875 GLI2 ZNF778 ZNF443 CASZ1	8.33e-03	808	54	7	SM00355
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	LIMK1 STRAP WDR6 GLI2 MACF1 STIL CASZ1	2.21e-06	358	58	7	32460013
Pubmed	The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1.	GBP1 GBP3	2.73e-06	2	58	2	7518790
Pubmed	A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.	ATXN7 PIP5KL1 CASZ1	4.92e-06	20	58	3	34127677
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLGAP1 SYNE1 PIP5KL1 MACF1 AKAP11 LRRC7	7.50e-06	281	58	6	28706196
Pubmed	The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.	GBP1 GBP3	8.19e-06	3	58	2	11726669
Pubmed	GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.	GBP1 GBP3	8.19e-06	3	58	2	38636926
Pubmed	Assignment of the human GLI2 gene to 2q14 by fluorescence in situ hybridization.	ZNF875 GLI2	8.19e-06	3	58	2	8812445
Pubmed	Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.	GBP1 GBP3	8.19e-06	3	58	2	30062052
Pubmed	Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.	GBP1 GBP3	8.19e-06	3	58	2	36639389
Pubmed	Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.	GBP1 GBP3	8.19e-06	3	58	2	26416908
Pubmed	Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.	GBP1 GBP3	8.19e-06	3	58	2	32354743
Pubmed	GTPase properties of the interferon-induced human guanylate-binding protein 2.	GBP1 GBP3	8.19e-06	3	58	2	8706832
Pubmed	The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.	GBP1 GBP3	8.19e-06	3	58	2	16914101
Pubmed	Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.	GBP1 GBP3	8.19e-06	3	58	2	32620042
Pubmed	[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].	GBP1 GBP3	8.19e-06	3	58	2	29089068
Pubmed	The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.	GBP1 GBP3	8.19e-06	3	58	2	22730319
Pubmed	Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain.	GBP1 GBP3	8.19e-06	3	58	2	15717119
Pubmed	Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.	GBP1 GBP3	8.19e-06	3	58	2	35383115
Pubmed	Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.	GBP1 GBP3	8.19e-06	3	58	2	23248289
Pubmed	Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.	GBP1 GBP3	8.19e-06	3	58	2	1715024
Pubmed	Role of GTP binding, isoprenylation, and the C-terminal α-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2.	GBP1 GBP3	8.19e-06	3	58	2	20950129
Pubmed	Two families of GTPases dominate the complex cellular response to IFN-gamma.	GBP1 GBP3	8.19e-06	3	58	2	9862701
Pubmed	Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family.	GBP1 GBP3	1.64e-05	4	58	2	10386861
Pubmed	Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection.	GBP1 GBP3	1.64e-05	4	58	2	38404575
Pubmed	Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon.	GBP1 GBP3	1.64e-05	4	58	2	7823961
Pubmed	Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.	GBP1 GBP3	1.64e-05	4	58	2	36609599
Pubmed	cDNA for the beta 1 subunit of guanyl nucleotide-binding regulatory proteins from mouse adrenal glands.	GBP1 GBP3	1.64e-05	4	58	2	8917111
Pubmed	The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.	GBP1 GBP3	1.64e-05	4	58	2	39337476
Pubmed	Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.	GBP1 GBP3	2.72e-05	5	58	2	21151871
Pubmed	Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection.	GBP1 GBP3	2.72e-05	5	58	2	31964735
Pubmed	Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages.	GBP1 GBP3	2.72e-05	5	58	2	9858320
Pubmed	TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.	GBP1 GBP3	2.72e-05	5	58	2	30858199
Pubmed	Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.	GBP1 GBP3	2.72e-05	5	58	2	12396730
Pubmed	Unique features of different members of the human guanylate-binding protein family.	GBP1 GBP3	2.72e-05	5	58	2	17266443
Pubmed	Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene.	GBP1 GBP3	4.08e-05	6	58	2	17293456
Pubmed	Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.	GBP1 GBP3	4.08e-05	6	58	2	21757726
Pubmed	The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase.	GBP1 GBP3	5.71e-05	7	58	2	20505078
Pubmed	The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.	GBP1 GBP3	5.71e-05	7	58	2	21502320
Pubmed	The GLI-Kruppel family of human genes.	ZNF875 GLI2	5.71e-05	7	58	2	2850480
Pubmed	TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis.	GBP1 GBP3	5.71e-05	7	58	2	30587103
Pubmed	In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.	GBP1 GBP3	7.60e-05	8	58	2	16689661
Pubmed	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	AMT AHCY BHMT2	7.68e-05	49	58	3	19161160
Pubmed	Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.	GBP1 GBP3	9.77e-05	9	58	2	24739961
Pubmed	Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.	GBP1 GBP3	9.77e-05	9	58	2	33479228
Pubmed	The doublecortin gene family and disorders of neuronal structure.	DCDC1 RP1	1.22e-04	10	58	2	20236041
Pubmed	Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.	GBP1 GBP3	1.22e-04	10	58	2	28334111
Pubmed	The evolving doublecortin (DCX) superfamily.	DCDC1 RP1	1.22e-04	10	58	2	16869982
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	GLI2 SYNE1	1.49e-04	11	58	2	27621083
Pubmed	Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.	GBP1 GBP3	1.49e-04	11	58	2	24715728
Pubmed	IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.	GBP1 GBP3	1.49e-04	11	58	2	27693356
Pubmed	Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals.	SYNE1 CREB3	1.49e-04	11	58	2	26939788
Pubmed	Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.	GBP1 GBP3	1.49e-04	11	58	2	18025219
Pubmed	Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors.	MACF1 LRRC7	1.49e-04	11	58	2	39256359
Pubmed	Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.	GBP1 GBP3	1.78e-04	12	58	2	35906252
Pubmed	LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.	GBP1 GBP3	1.78e-04	12	58	2	29459437
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	LIMK1 AMT GLI2 AHCY BHMT2	2.30e-04	331	58	5	20634891
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	STRAP ACLY AHCY SF3B2	2.37e-04	180	58	4	30110629
Pubmed	Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.	AHCY BHMT2	2.46e-04	14	58	2	30753104
Pubmed	Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.	GBP1 GBP3	2.83e-04	15	58	2	25774716
Pubmed	Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.	GBP1 GBP3	2.83e-04	15	58	2	17114464
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	KANK1 STRAP GLI2 CREB3	2.97e-04	191	58	4	24146773
Pubmed	Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.	AHCY BHMT2	3.66e-04	17	58	2	20458436
Pubmed	The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.	GBP1 GBP3	3.66e-04	17	58	2	25774715
Pubmed	Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.	AHCY BHMT2	3.66e-04	17	58	2	18635682
Pubmed	High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism.	AHCY BHMT2	3.66e-04	17	58	2	18427977
Pubmed	Congenital Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	POMGNT2 SYNE1	3.66e-04	17	58	2	20301468
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	GALK1 STRAP ACLY SYNE1 AHCY MACF1 GBP3	3.79e-04	807	58	7	30575818
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GALK1 PLAA WDR6 ACLY MYO19 AHCY MACF1 RIC8A SF3B2	3.80e-04	1353	58	9	29467282
Pubmed	The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.	GBP1 GBP3	4.11e-04	18	58	2	27001747
Pubmed	Quantitative analysis of PPT1 interactome in human neuroblastoma cells.	ATP5PO STRAP ACLY STIL	4.25e-04	210	58	4	26217791
Pubmed	Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.	CRYGN GLI2	4.59e-04	19	58	2	23201579
Pubmed	A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.	GBP1 GBP3	4.59e-04	19	58	2	21551061
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	GALK1 ATP5PO MACF1 RIC8A ARIH1 SF3B2	4.91e-04	601	58	6	33658012
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	GALK1 ATP7B PLAA WDR6 ACLY	4.98e-04	392	58	5	33144569
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	PLAA ACLY SF3B2 CASZ1	5.06e-04	220	58	4	35785414
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GALK1 ATP7B DCDC1 ATXN7 WDR6 MACF1 RIC8A ABHD8	5.06e-04	1116	58	8	31753913
Pubmed	Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.	GBP1 GBP3	5.09e-04	20	58	2	32150572
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SYNE1 MACF1	5.09e-04	20	58	2	21689717
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	GALK1 POMGNT2 STRAP AHCY ARIH1 SF3B2	5.44e-04	613	58	6	22268729
Pubmed	An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.	GBP1 GBP3	5.62e-04	21	58	2	19158679
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KANK1 STARD9 SYNE1 MACF1 LRRC7	5.90e-04	407	58	5	12693553
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	ATXN7 STARD9 SYNE1 CASZ1	6.27e-04	233	58	4	37704626
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	ACLY SYNE1 MACF1 SF3B2	6.37e-04	234	58	4	36243803
Pubmed	A protein interaction landscape of breast cancer.	PLAA STRAP MYO19 AHCY MACF1 RIC8A	6.49e-04	634	58	6	34591612
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	GALK1 ATP5PO STRAP ACLY AHCY SF3B2	7.21e-04	647	58	6	26618866
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	DLGAP1 ATP5PO STARD9 MACF1 LRRC7	7.55e-04	430	58	5	32581705
Pubmed	Holoprosencephaly Overview	GLI2 STIL	8.00e-04	25	58	2	20301702
Pubmed	Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.	GBP1 GBP3	8.00e-04	25	58	2	35139355
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DLGAP1 SYNE1 MACF1 LRRC7	8.28e-04	251	58	4	27507650
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	STRAP ACLY AHCY SF3B2	9.17e-04	258	58	4	21081666
Pubmed	Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.	DCDC1 AKAP11	9.34e-04	27	58	2	19801982
Pubmed	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	AHCY BHMT2	1.08e-03	29	58	2	19048631
Pubmed	The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.	DLGAP1 LRRC7	1.08e-03	29	58	2	19208628
Pubmed	Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.	GBP1 GBP3	1.08e-03	29	58	2	33278357
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	KANK1 AHCY AKAP11	1.21e-03	125	58	3	29467281
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	AHCY SF3B2	1.23e-03	31	58	2	22323290
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	ATP5PO ACLY AHCY SF3B2	1.26e-03	281	58	4	30455355
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	GALK1 ATP5PO PLAA STRAP WDR6 SF3B2	1.30e-03	725	58	6	27025967
Pubmed	Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.	AHCY BHMT2	1.40e-03	33	58	2	34702858
Pubmed	Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.	ACLY AHCY	1.40e-03	33	58	2	29149599
Cytoband	1p32	STIL RAD54L	5.40e-04	27	58	2	1p32
Cytoband	1p22.2	GBP1 GBP3	5.81e-04	28	58	2	1p22.2
GeneFamily	Doublecortin superfamily	DCDC1 RP1	1.72e-04	10	36	2	1369
GeneFamily	WD repeat domain containing	PLAA CFAP52 STRAP WDR6	1.76e-03	262	36	4	362
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB38 ZNF875 GLI2 ZNF778 ZNF443 CASZ1	2.70e-03	718	36	6	28
Coexpression	GSE43955_1H_VS_60H_ACT_CD4_TCELL_DN	SLC22A9 RHOH PLAA IL17RA STIL RAD54L	5.18e-06	199	58	6	M9651
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Neurod2\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PRODH2 BHMT2 SLC5A12 QRICH2	2.82e-06	75	58	4	3bc5df14f21c1c93c2a0fd5fc47bc5d146ba87a2
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	DCDC1 CFAP52 SYNE1 MACF1 RP1	5.66e-06	196	58	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	DCDC1 CFAP52 SYNE1 MACF1 RP1	5.66e-06	196	58	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Deuterosomal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DCDC1 CFAP52 UMODL1 RP1 STIL	5.95e-06	198	58	5	f31790442ef142f1c0c49bf3daf2d0efb193d2c9
ToppCell	Leuk-UTI-Lymphocyte-T_NK-gdT\|Leuk-UTI / Disease, Lineage and Cell Type	SLC22A9 CFAP52 SYNE1 ZNF443	5.36e-05	158	58	4	c4b0af25608cee3d0d2b0193f5ff45d9dc87078b
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ATXN7 SYNE1 MACF1 ARIH1	7.28e-05	171	58	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDPR UMODL1 CRYGN GBP1	8.14e-05	176	58	4	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRODH2 BHMT2 LRRC7 SLC5A12	8.88e-05	180	58	4	f8bdfd7bf7b3d52c659a29d8f5f80858e79da83e
ToppCell	severe-multiplets\|severe / disease stage, cell group and cell class	AMT SYNE1 GRM6 RAD54L	9.47e-05	183	58	4	78af8df48f0fe49ac37ccec0ad7b2993883b1148
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Neurod2-Excitatory_Neuron.Slc17a7.Neurod2-Rorb_(Nucleus_of_the_lateral_olfactory_tract_(LOT))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PRODH2 BHMT2 QRICH2	9.60e-05	68	58	3	6945089858778301a05ecc5895310d768768758c
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Neurod2-Excitatory_Neuron.Slc17a7.Neurod2-Rorb_(Nucleus_of_the_lateral_olfactory_tract_(LOT))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PRODH2 BHMT2 QRICH2	9.60e-05	68	58	3	ac9d0f473c878b96a422bbdd7088eb8125574dde
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 DCDC1 SYNE1 RP1	1.01e-04	186	58	4	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PRODH2 BHMT2 SLC5A12	1.07e-04	189	58	4	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PRODH2 BHMT2 SLC5A12	1.07e-04	189	58	4	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 KANK1 DCDC1 SLC5A12	1.07e-04	189	58	4	28b502611829e4a24caff2562545c7db97686099
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	DCDC1 CFAP52 SYNE1 RP1	1.09e-04	190	58	4	9ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DCDC1 CFAP52 SYNE1 RP1	1.09e-04	190	58	4	833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LRRC7 STIL CASZ1 RAD54L	1.09e-04	190	58	4	e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 KANK1 BHMT2 SLC5A12	1.12e-04	191	58	4	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 KANK1 BHMT2 SLC5A12	1.12e-04	191	58	4	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	GBP1 STIL MMP12 RAD54L	1.14e-04	192	58	4	4e689bca7a242f8482e25f273656e2caba8821c0
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	DCDC1 CFAP52 SYNE1 RP1	1.14e-04	192	58	4	be592e661367affced9ebe80849b466e6adb3a34
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DCDC1 CFAP52 SYNE1 RP1	1.16e-04	193	58	4	0b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DCDC1 CFAP52 SYNE1 RP1	1.16e-04	193	58	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	DCDC1 CFAP52 SYNE1 RP1	1.19e-04	194	58	4	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	DCDC1 CFAP52 SYNE1 RP1	1.19e-04	194	58	4	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	DCDC1 CFAP52 SYNE1 RP1	1.21e-04	195	58	4	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DCDC1 CFAP52 RP1 CPLANE1	1.21e-04	195	58	4	79dc031258579ea328181dda33710dd897f1064a
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	DCDC1 CFAP52 SYNE1 RP1	1.21e-04	195	58	4	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRODH2 GALK1 AHCY BHMT2	1.21e-04	195	58	4	eb96439b59914954f684c4bfd9e9a6dbd3201a20
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DCDC1 CFAP52 SYNE1 RP1	1.21e-04	195	58	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	NS-control-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DCDC1 CFAP52 SYNE1 RP1	1.23e-04	196	58	4	d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell	COVID_non-vent-Lymphocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	RHOH ZBTB38 SYNE1 MACF1	1.26e-04	197	58	4	c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DCDC1 CFAP52 SYNE1 RP1	1.26e-04	197	58	4	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DCDC1 CFAP52 SYNE1 RP1	1.26e-04	197	58	4	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	T_cells-CTLs\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ZBTB38 SYNE1 GBP1 CASZ1	1.26e-04	197	58	4	28117cf300e169182571fbad0de1681a484a435a
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DCDC1 SYNE1 RP1 CPLANE1	1.26e-04	197	58	4	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DCDC1 CFAP52 SYNE1 RP1	1.26e-04	197	58	4	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DCDC1 CFAP52 SYNE1 RP1	1.26e-04	197	58	4	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DCDC1 CFAP52 SYNE1 RP1	1.28e-04	198	58	4	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	DLGAP1 GBP1 MACF1 AKAP11	1.28e-04	198	58	4	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	STIL ZNF443 CASZ1 RAD54L	1.31e-04	199	58	4	26bb93347e6722abd174dfa62cab692ce2b7eb23
ToppCell	healthy_donor-Lymphocytic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	RHOH ZBTB38 SYNE1 MACF1	1.31e-04	199	58	4	2841e16d54acd344ba454f024e285c28abc37319
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	DCDC1 CFAP52 SYNE1 RP1	1.33e-04	200	58	4	6a2ccc71a0cbe04a542c379b28b5006de53981c3
Disease	uterine fibroid	KANK1 SYNE1 RIC8A CASZ1	6.41e-04	199	58	4	EFO_0000731
Disease	Hepatic Form of Wilson Disease	ATP7B AHCY	1.02e-03	24	58	2	C1527352
Disease	Hepatolenticular Degeneration	ATP7B AHCY	1.02e-03	24	58	2	C0019202
Disease	Acute kidney injury	GBP1 GBP3	1.11e-03	25	58	2	HP_0001919
Disease	Malignant neoplasm of breast	SLC22A9 ATP7B SYNE1 MACF1 RIC8A LRRC7 GRM6 RAD54L	1.14e-03	1074	58	8	C0006142
Disease	clear cell renal cell carcinoma (is_marker_for)	ATP5PO MMP12	1.93e-03	33	58	2	DOID:4467 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VRGSLPATMCQHMDA	UMODL1	826	Q5DID0
PATMCQHMDAGGVRM	UMODL1	831	Q5DID0
PGCRHTVVGMSQMDS	CASZ1	1576	Q86V15
AGMTCASCVHSIEGM	ATP7B	366	P35670
NQSHPSGMLCVMRVS	AKAP11	116	Q9UKA4
HAPSGVMTMGRCPDR	DLGAP1	216	O14490
ENMCPSMNLFSHGTR	ACRV1	236	P26436
MMSVHRGEVPCTVTS	ATP5PO	131	P48047
GSHMVMLECPETVNT	ABHD8	396	Q96I13
GPMCHLMVASHNEES	PRODH2	426	Q9UF12
QHGMTFPGTDQRSME	QRICH2	306	Q9H0J4
RRIPGSHGCIMADEM	RAD54L	171	Q92698
TSTLEMMHAPRCGVP	MMP12	81	P39900
MEEGMGQTISCPAHG	ARIH1	221	Q9Y4X5
DMVICVSMGHGFKTP	DCDC1	1726	M0R2J8
EHARMKVTTPCMSSG	IL17RA	186	Q96F46
ISPGHELHGMTCMMQ	PIP5KL1	46	Q5T9C9
GPEHGMSSMSRSQSV	LRRC7	986	Q96NW7
GDSAEAMPAPMHCGR	MYO19	726	Q96H55
RQSCMSVPGMSTGTV	ARNTL2	496	Q8WYA1
TVPNMTCHGIDFMRD	CFAP52	371	Q8N1V2
ANGIRVMSMTHTGEP	PDPR	661	Q8NCN5
SQPSGDMTEAHMPCV	FAM205A	996	Q6ZU69
QQAEHSFAGMPCGIM	GALK1	171	P51570
MVGSHMDLVDTCVGT	KANK1	526	Q14678
HMTGPMCLIENTNGR	GBP1	6	P32455
HMTGPMCLIENTNGE	GBP3	6	Q9H0R5
GSQCPGMTTTMSPHA	GLI2	1231	P10070
GMTTTMSPHACYGQV	GLI2	1236	P10070
MVTMCGGHRPENFLH	PMS2P1	1	A4D2B8
MEGGTHMVCTGRTHT	POMGNT2	61	Q8NAT1
RPCHLSQGPAMMSGN	POU2F3	61	Q9UKI9
ASGAMDPVCSMQSRQ	ATXN7	631	O15265
NSHSDHMGSCRPVGM	CRYGN	76	Q8WXF5
SPGMMHGIVDPENCR	MACF1	2616	Q9UPN3
HTGLCPAMEPTDGRM	GRM6	426	O15303
PVAVTMCIGPEGDMH	BHMT2	171	Q9H2M3
VHPMMMDRSENRCGG	CPZ	421	Q66K79
RHCVVKGPQTEEMMS	CPLANE1	1391	Q9H799
VGLMCEGAPMRAHSP	AMT	321	P48728
SCRKEGTQMTPQHME	CREB3	96	O43889
NLGCAMGHPSFVMSN	AHCY	346	P23526
NHLLRMSSENPGMCG	RP1	1751	P56715
DSMTFGGPSTINEMC	MOXD2P	451	A6NHM9
AHPSVVMMTAGRCHT	SYNE1	5841	Q8NF91
THRFQAMGITLGMCP	SLC22A9	226	Q8IVM8
REMGPHRASCVNAME	RHOH	121	Q15669
VRSMAMGSHSQSGVP	STARD9	2411	Q9P2P6
MSPRGHLTSLQDAMC	RIC8A	501	Q9NPQ8
MAMRQTPLTCSGHTR	STRAP	1	Q9Y3F4
EMCLMVTADHGPAVS	ACLY	891	P53396
RRPEMGDQAHMPCTT	CYP2D7	361	A0A087X1C5
RTATVGGAMMGSTHI	SF3B2	791	Q13435
TVCMHTPKTESDNGM	STIL	701	Q15468
HSMGCATPVEMHAVR	ZNF778	236	Q96MU6
PNRSFTEMHCMSGHS	PLAA	51	Q9Y263
GGRAEMHCFSIMVTP	WDR6	806	Q9NNW5
GPCESSMRGEKVMGH	ZNF443	101	Q9Y2A4
LPTCMVHRQTMSCSG	ZNF875	11	P10072
QICMRSSHMPIPGGN	ZBTB38	391	Q8NAP3
VQASLSIHGMCGGPM	SLC5A12	406	Q1EHB4
SHTVRVQGVDPGCMS	LIMK1	196	P53667