Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	SETX CHD9 UPF1 FBH1 RECQL5 RAD54B POLQ RAD54L	7.67e-07	127	116	8	GO:0008094
GeneOntologyMolecularFunction	DNA helicase activity	SETX UPF1 FBH1 RECQL5 RAD54B POLQ	1.59e-06	62	116	6	GO:0003678
GeneOntologyMolecularFunction	DNA translocase activity	FBH1 RAD54B RAD54L	1.89e-06	5	116	3	GO:0015616
GeneOntologyMolecularFunction	helicase activity	SETX CHD9 UPF1 FBH1 RECQL5 RAD54B POLQ RAD54L	3.97e-06	158	116	8	GO:0004386
GeneOntologyMolecularFunction	ATP-dependent activity	MYO1G SETX IPO8 LONP2 MYO1H CHD9 UPF1 ATAD2 FBH1 RECQL5 RAD54B POLQ RAD54L	5.86e-05	614	116	13	GO:0140657
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR2	1.00e-04	3	116	2	GO:0005220
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	SETX CHD9 UPF1 FBH1 RECQL5 RAD54B POLQ RAD54L	1.48e-04	262	116	8	GO:0140097
GeneOntologyMolecularFunction	pyrophosphatase activity	LONP2 GBP2 GBP3 CHD9 UPF1 ATAD2 RHOB EEF2 CILP2 FBH1 GBP5 RECQL5 POLQ RAD54L	3.64e-04	839	116	14	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	LONP2 GBP2 GBP3 CHD9 UPF1 ATAD2 RHOB EEF2 CILP2 FBH1 GBP5 RECQL5 POLQ RAD54L	3.69e-04	840	116	14	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	LONP2 GBP2 GBP3 CHD9 UPF1 ATAD2 RHOB EEF2 CILP2 FBH1 GBP5 RECQL5 POLQ RAD54L	3.69e-04	840	116	14	GO:0016818
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	LONP2 GBP2 GBP3 CHD9 UPF1 ATAD2 RHOB EEF2 FBH1 GBP5 RECQL5 POLQ RAD54L	5.68e-04	775	116	13	GO:0017111
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD9 RAD54B RAD54L	1.29e-03	37	116	3	GO:0140658
GeneOntologyBiologicalProcess	positive regulation of AIM2 inflammasome complex assembly	GBP2 GBP3 GBP5	7.09e-07	4	117	3	GO:0140973
GeneOntologyBiologicalProcess	regulation of AIM2 inflammasome complex assembly	GBP2 GBP3 GBP5	3.51e-06	6	117	3	GO:0140971
GeneOntologyBiologicalProcess	DNA duplex unwinding	SETX UPF1 FBH1 RECQL5 RAD54B POLQ	5.39e-06	78	117	6	GO:0032508
GeneOntologyBiologicalProcess	DNA geometric change	SETX UPF1 FBH1 RECQL5 RAD54B POLQ	9.51e-06	86	117	6	GO:0032392
GeneOntologyBiologicalProcess	AIM2 inflammasome complex assembly	GBP2 GBP3 GBP5	9.76e-06	8	117	3	GO:0140970
GeneOntologyBiologicalProcess	cytolysis in another organism	GBP2 GBP3 GBP5	1.46e-05	9	117	3	GO:0051715
GeneOntologyBiologicalProcess	positive regulation of pyroptotic inflammatory response	GBP2 GBP3 GBP5	1.46e-05	9	117	3	GO:0140639
GeneOntologyBiologicalProcess	DNA conformation change	SETX UPF1 FBH1 RECQL5 RAD54B POLQ	1.59e-05	94	117	6	GO:0071103
GeneOntologyBiologicalProcess	DNA repair	USP45 SETX CHAF1A UPF1 ZBTB1 SETD2 ADPRS FBH1 UBR5 MORF4L1 RECQL5 RAD54B POLQ RAD54L	1.85e-05	648	117	14	GO:0006281
GeneOntologyBiologicalProcess	cytolysis	GBP2 GBP3 GBP5	3.77e-05	12	117	3	GO:0019835
GeneOntologyBiologicalProcess	positive regulation of neuron projection development	SETX DBNL ZNF804A ITPR1 FBXO38 PPP2R5B FUT9 EP300	8.86e-05	249	117	8	GO:0010976
GeneOntologyBiologicalProcess	double-strand break repair via homologous recombination	SETD2 FBH1 MORF4L1 RECQL5 RAD54B POLQ RAD54L	9.96e-05	188	117	7	GO:0000724
GeneOntologyBiologicalProcess	DNA damage response	USP45 SETX ACD CHAF1A UPF1 ZBTB1 SETD2 ADPRS FBH1 UBR5 MORF4L1 RECQL5 RAD54B POLQ EP300 RAD54L	1.03e-04	959	117	16	GO:0006974
GeneOntologyBiologicalProcess	regulation of double-strand break repair via homologous recombination	SETD2 FBH1 MORF4L1 RECQL5 POLQ	1.10e-04	83	117	5	GO:0010569
GeneOntologyBiologicalProcess	recombinational repair	SETD2 FBH1 MORF4L1 RECQL5 RAD54B POLQ RAD54L	1.21e-04	194	117	7	GO:0000725
GeneOntologyBiologicalProcess	DNA metabolic process	USP45 SETX ACD CHAF1A UPF1 ZBTB1 ESCO1 SETD2 ADPRS FBH1 UBR5 MORF4L1 RECQL5 RAD54B POLQ RAD54L IL7R	1.26e-04	1081	117	17	GO:0006259
GeneOntologyBiologicalProcess	regulation of DNA recombination	SETD2 FBH1 MORF4L1 RECQL5 POLQ IL7R	2.16e-04	150	117	6	GO:0000018
GeneOntologyBiologicalProcess	DNA recombination	SETX SETD2 FBH1 MORF4L1 RECQL5 RAD54B POLQ RAD54L IL7R	2.52e-04	368	117	9	GO:0006310
GeneOntologyCellularComponent	symbiont cell surface	GBP2 GBP3 GBP5	9.87e-06	8	119	3	GO:0106139
GeneOntologyCellularComponent	other organism part	GBP2 GBP3 GBP5	1.47e-05	9	119	3	GO:0044217
GeneOntologyCellularComponent	Mon1-Ccz1 complex	CCZ1B CCZ1	3.18e-04	5	119	2	GO:0035658
GeneOntologyCellularComponent	intracellular protein-containing complex	CCZ1B DET1 KBTBD8 POLR3A FBXL4 ITPR1 FBXO38 FBH1 CCZ1 LMO7 MORF4L1 MED17 PRAMEF26 EP300 NAA16	4.15e-04	972	119	15	GO:0140535
GeneOntologyCellularComponent	host cell part	GBP2 GBP3	4.75e-04	6	119	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP2 GBP3	4.75e-04	6	119	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP2 GBP3	4.75e-04	6	119	2	GO:0033655
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP2 GBP3	4.75e-04	6	119	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP2 GBP3	4.75e-04	6	119	2	GO:0020005
GeneOntologyCellularComponent	host intracellular region	GBP2 GBP3	4.75e-04	6	119	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP2 GBP3	4.75e-04	6	119	2	GO:0030430
GeneOntologyCellularComponent	ubiquitin ligase complex	DET1 KBTBD8 FBXL4 FBXO38 FBH1 LMO7 MED17 PRAMEF26	9.26e-04	352	119	8	GO:0000151
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR1 ITPR2	1.13e-03	9	119	2	GO:0031095
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	DET1 KBTBD8 FBXL4 FBXO38 FBH1 PRAMEF26	1.36e-03	212	119	6	GO:0031461
GeneOntologyCellularComponent	platelet dense tubular network	ITPR1 ITPR2	1.71e-03	11	119	2	GO:0031094
HumanPheno	Abnormal spinal cord physiology	MPO ITPR1 PLAU	2.88e-05	9	37	3	HP:0034482
HumanPheno	Long-tract signs	MPO ITPR1 PLAU	2.88e-05	9	37	3	HP:0002423
Domain	GBP_C	GBP2 GBP3 GBP5	2.71e-05	10	116	3	PF02841
Domain	G_GB1_RHD3_dom	GBP2 GBP3 GBP5	3.71e-05	11	116	3	IPR030386
Domain	Guanylate-bd_N	GBP2 GBP3 GBP5	3.71e-05	11	116	3	IPR015894
Domain	Guanylate-bd_C	GBP2 GBP3 GBP5	3.71e-05	11	116	3	IPR003191
Domain	GBP	GBP2 GBP3 GBP5	3.71e-05	11	116	3	PF02263
Domain	G_GB1_RHD3	GBP2 GBP3 GBP5	3.71e-05	11	116	3	PS51715
Domain	DUF1712	CCZ1B CCZ1	3.82e-05	2	116	2	PF08217
Domain	DUF1712_fun	CCZ1B CCZ1	3.82e-05	2	116	2	IPR013176
Domain	-	SETX LONP2 GBP2 GBP3 CHD9 UPF1 ATAD2 RHOB EEF2 FBH1 GBP5 RECQL5 RAD54B POLQ RAD54L	5.91e-05	746	116	15	3.40.50.300
Domain	P-loop_NTPase	MYO1G SETX LONP2 GBP2 GBP3 CHD9 UPF1 ATAD2 RHOB EEF2 FBH1 GBP5 RECQL5 RAD54B POLQ RAD54L	6.99e-05	848	116	16	IPR027417
Domain	Ferritin-like_SF	SETD2 MOB3C MOB3B	8.08e-05	14	116	3	IPR009078
Domain	InsP3_rcpt-bd	ITPR1 ITPR2	1.14e-04	3	116	2	IPR000493
Domain	Helicase_C	CHD9 RECQL5 RAD54B POLQ RAD54L	5.44e-04	107	116	5	PF00271
Domain	HELICc	CHD9 RECQL5 RAD54B POLQ RAD54L	5.44e-04	107	116	5	SM00490
Domain	RIH_assoc-dom	ITPR1 ITPR2	5.64e-04	6	116	2	IPR013662
Domain	Ins145_P3_rec	ITPR1 ITPR2	5.64e-04	6	116	2	PF08709
Domain	RIH_assoc	ITPR1 ITPR2	5.64e-04	6	116	2	PF08454
Domain	RIH_dom	ITPR1 ITPR2	5.64e-04	6	116	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR2	5.64e-04	6	116	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR2	5.64e-04	6	116	2	IPR015925
Domain	-	ITPR1 ITPR2	5.64e-04	6	116	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR2	5.64e-04	6	116	2	PF01365
Domain	Helicase_C	CHD9 RECQL5 RAD54B POLQ RAD54L	5.68e-04	108	116	5	IPR001650
Domain	HELICASE_CTER	CHD9 RECQL5 RAD54B POLQ RAD54L	5.92e-04	109	116	5	PS51194
Domain	HELICASE_ATP_BIND_1	CHD9 RECQL5 RAD54B POLQ RAD54L	5.92e-04	109	116	5	PS51192
Domain	DEXDc	CHD9 RECQL5 RAD54B POLQ RAD54L	5.92e-04	109	116	5	SM00487
Domain	Helicase_ATP-bd	CHD9 RECQL5 RAD54B POLQ RAD54L	6.17e-04	110	116	5	IPR014001
Domain	Mob1_phocein	MOB3C MOB3B	7.87e-04	7	116	2	PF03637
Domain	MOB_kinase_act_fam	MOB3C MOB3B	7.87e-04	7	116	2	IPR005301
Domain	-	MOB3C MOB3B	7.87e-04	7	116	2	1.20.140.30
Domain	Mob1_phocein	MOB3C MOB3B	7.87e-04	7	116	2	SM01388
Domain	SNF2_N	CHD9 RAD54B RAD54L	1.02e-03	32	116	3	IPR000330
Domain	SNF2_N	CHD9 RAD54B RAD54L	1.02e-03	32	116	3	PF00176
Domain	BROMODOMAIN_1	ATAD2 EP300 SP140	1.56e-03	37	116	3	PS00633
Domain	MIR	ITPR1 ITPR2	1.67e-03	10	116	2	PF02815
Domain	MIR_motif	ITPR1 ITPR2	1.67e-03	10	116	2	IPR016093
Domain	MIR	ITPR1 ITPR2	1.67e-03	10	116	2	PS50919
Domain	MIR	ITPR1 ITPR2	1.67e-03	10	116	2	SM00472
Domain	Bromodomain	ATAD2 EP300 SP140	1.68e-03	38	116	3	PF00439
Domain	BROMODOMAIN_2	ATAD2 EP300 SP140	2.10e-03	41	116	3	PS50014
Domain	Bromodomain	ATAD2 EP300 SP140	2.25e-03	42	116	3	IPR001487
Domain	BROMO	ATAD2 EP300 SP140	2.25e-03	42	116	3	SM00297
Domain	-	ATAD2 EP300 SP140	2.25e-03	42	116	3	1.20.920.10
Domain	Ras_G-nucl-exch_fac_CS	RASGRF1 RASGRF2	3.31e-03	14	116	2	IPR019804
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	RDM1 UPF1 ESCO1 FBH1 LMO7 RECQL5 POLQ EP300	1.02e-07	157	124	8	30686591
Pubmed	Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection.	GBP2 GBP3 GBP5	1.76e-07	4	124	3	38404575
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	MPO NR2C2 SETX IPO8 CHD9 UPF1 PPWD1 EEF2 UBR5 CCZ1 MORF4L1 SNRNP40 MED17 EIF2A EP300 PRRC2B ZNF292	4.18e-07	1103	124	17	34189442
Pubmed	Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.	GBP2 GBP3 GBP5	4.40e-07	5	124	3	12396730
Pubmed	Unique features of different members of the human guanylate-binding protein family.	GBP2 GBP3 GBP5	4.40e-07	5	124	3	17266443
Pubmed	Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.	GBP2 GBP3 GBP5	4.40e-07	5	124	3	21151871
Pubmed	BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor.	ITPR1 ITPR2 BANK1	4.40e-07	5	124	3	11782428
Pubmed	Insulin-like growth factors II exon 9 and E-cadherin-Pml I but not myeloperoxidase promoter-463, urokinase-ApaL I nor xeroderma pigmentosum polymorphisms are associated with higher susceptibility to leiomyoma.	MPO PLAU CDH1	8.78e-07	6	124	3	20651370
Pubmed	In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.	GBP2 GBP3 GBP5	2.45e-06	8	124	3	16689661
Pubmed	Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.	GBP2 GBP3 GBP5	3.66e-06	9	124	3	24739961
Pubmed	Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.	GBP2 GBP3 GBP5	3.66e-06	9	124	3	33479228
Pubmed	Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.	GBP2 GBP3 GBP5	7.15e-06	11	124	3	24715728
Pubmed	Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling.	UNC5B SLC16A3 ADGRE1	7.15e-06	11	124	3	28576770
Pubmed	IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.	GBP2 GBP3 GBP5	7.15e-06	11	124	3	27693356
Pubmed	Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.	GBP2 GBP3 GBP5	7.15e-06	11	124	3	18025219
Pubmed	Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.	GBP2 GBP3 GBP5	9.51e-06	12	124	3	35906252
Pubmed	LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.	GBP2 GBP3 GBP5	9.51e-06	12	124	3	29459437
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	NR2C2 SETX CHAF1A CHD9 ATAD2 FBXO38 MORF4L1 RECQL5 RAD54B SCAF11 ZNF292	1.21e-05	608	124	11	36089195
Pubmed	RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.	RASGRF1 RASGRF2	1.26e-05	2	124	2	26743081
Pubmed	Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice.	GBP2 GBP5	1.26e-05	2	124	2	29467757
Pubmed	Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.	RASGRF1 RASGRF2	1.26e-05	2	124	2	16467520
Pubmed	Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice.	ITPR1 ITPR2	1.26e-05	2	124	2	15201137
Pubmed	Homology-driven chromatin remodeling by human RAD54.	RAD54B RAD54L	1.26e-05	2	124	2	17417655
Pubmed	Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer.	ITGB2 PLAU	1.26e-05	2	124	2	18076013
Pubmed	Sulphide signalling potentiates apoptosis through the up-regulation of IP3 receptor types 1 and 2.	ITPR1 ITPR2	1.26e-05	2	124	2	23582047
Pubmed	The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.	RASGRF1 RASGRF2	1.26e-05	2	124	2	17141611
Pubmed	Genetic probing of homologous recombination and non-homologous end joining during meiotic prophase in irradiated mouse spermatocytes.	RAD54B RAD54L	1.26e-05	2	124	2	20167225
Pubmed	Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.	RASGRF1 RASGRF2	1.26e-05	2	124	2	19193896
Pubmed	Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination.	RAD54B RAD54L	1.26e-05	2	124	2	12548566
Pubmed	Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.	RASGRF1 RASGRF2	1.26e-05	2	124	2	14749369
Pubmed	β2 integrin-mediated cell-cell contact transfers active myeloperoxidase from neutrophils to endothelial cells.	MPO ITGB2	1.26e-05	2	124	2	23532856
Pubmed	Type 1 and 2 IP3 receptors respond differently to catecholamines and stress.	ITPR1 ITPR2	1.26e-05	2	124	2	19120126
Pubmed	A murine CDC25/ras-GRF-related protein implicated in Ras regulation.	RASGRF1 RASGRF2	1.26e-05	2	124	2	8293576
Pubmed	The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction.	RHOB CDH1	1.26e-05	2	124	2	25630770
Pubmed	Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.	GBP2 GBP5	1.26e-05	2	124	2	33876762
Pubmed	Oxidative modifications of extracellular matrix promote the second wave of inflammation via β2 integrins.	MPO ITGB2	1.26e-05	2	124	2	29724896
Pubmed	Inhibition of p300 histone acetyltransferase activity in palate mesenchyme cells attenuates Wnt signaling via aberrant E-cadherin expression.	CDH1 EP300	1.26e-05	2	124	2	26921506
Pubmed	An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown.	ITPR1 ITPR2	1.26e-05	2	124	2	18708078
Pubmed	Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus.	RASGRF1 RASGRF2	1.26e-05	2	124	2	28966131
Pubmed	The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.	RASGRF1 RASGRF2	1.26e-05	2	124	2	31182637
Pubmed	Characterization and expression analysis of the murine rck gene: a protein kinase with a potential function in sensory cells.	MAK CDH1	1.26e-05	2	124	2	8359591
Pubmed	DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation.	RAD54B RAD54L	1.26e-05	2	124	2	18353795
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	MPO IPO8 GBP2 CASP10 UPF1 ITPR1 SETD2 SLC16A3 UBR5 SSU72 SNRNP40 EP300	1.72e-05	754	124	12	35906200
Pubmed	Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.	GBP2 GBP3 GBP5	1.95e-05	15	124	3	17114464
Pubmed	Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.	GBP2 GBP3 GBP5	1.95e-05	15	124	3	25774716
Pubmed	Hereditary Ataxia Overview	SETX OPHN1 POLR3A ITPR1 EEF2	2.04e-05	92	124	5	20301317
Pubmed	The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.	GBP2 GBP3 GBP5	2.90e-05	17	124	3	25774715
Pubmed	EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300.	ZBTB1 MED17 EP300	3.47e-05	18	124	3	24740910
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	NR2C2 SETX ACD ZBTB1 SETD2 UBR5 RECQL5 MED17 EP300	3.77e-05	453	124	9	29656893
Pubmed	DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4).	SETX UPF1	3.77e-05	3	124	2	15106121
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR2	3.77e-05	3	124	2	10874040
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR2	3.77e-05	3	124	2	20395455
Pubmed	RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.	RASGRF1 RASGRF2	3.77e-05	3	124	2	21685891
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR2	3.77e-05	3	124	2	17437169
Pubmed	The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.	UPF1 CDH1	3.77e-05	3	124	2	18427545
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	3.77e-05	3	124	2	32160108
Pubmed	GTPase properties of the interferon-induced human guanylate-binding protein 2.	GBP2 GBP3	3.77e-05	3	124	2	8706832
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR2	3.77e-05	3	124	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR2	3.77e-05	3	124	2	36350267
Pubmed	Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.	GBP2 GBP3	3.77e-05	3	124	2	32620042
Pubmed	[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].	GBP2 GBP3	3.77e-05	3	124	2	29089068
Pubmed	Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability.	ITPR1 ITPR2	3.77e-05	3	124	2	32320395
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR2	3.77e-05	3	124	2	11413485
Pubmed	Snail acetylation by histone acetyltransferase p300 in lung cancer.	CDH1 EP300	3.77e-05	3	124	2	28296173
Pubmed	MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress.	SETD2 MORF4L1	3.77e-05	3	124	2	28673974
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	3.77e-05	3	124	2	26009177
Pubmed	Rad54/Rad54B deficiency is associated to increased chromosome breakage in mouse spermatocytes.	RAD54B RAD54L	3.77e-05	3	124	2	30204892
Pubmed	Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations.	SLC16A3 CDH1	3.77e-05	3	124	2	32792680
Pubmed	Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.	GBP2 GBP3	3.77e-05	3	124	2	1715024
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR2	3.77e-05	3	124	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR2	3.77e-05	3	124	2	23955339
Pubmed	Two families of GTPases dominate the complex cellular response to IFN-gamma.	GBP2 GBP3	3.77e-05	3	124	2	9862701
Pubmed	Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.	RASGRF1 RASGRF2	3.77e-05	3	124	2	11909944
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR2	3.77e-05	3	124	2	31979185
Pubmed	The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.	GBP2 GBP3	3.77e-05	3	124	2	11726669
Pubmed	GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.	GBP2 GBP3	3.77e-05	3	124	2	38636926
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR2	3.77e-05	3	124	2	24904548
Pubmed	Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair.	RAD54B RAD54L	3.77e-05	3	124	2	19061978
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR2	3.77e-05	3	124	2	9858485
Pubmed	Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.	GBP2 GBP5	3.77e-05	3	124	2	31091448
Pubmed	RhoB controls the Rab11-mediated recycling and surface reappearance of LFA-1 in migrating T lymphocytes.	ITGB2 RHOB	3.77e-05	3	124	2	29233918
Pubmed	Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain.	GBP2 GBP3	3.77e-05	3	124	2	15717119
Pubmed	Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.	GBP2 GBP3	3.77e-05	3	124	2	35383115
Pubmed	Role of GTP binding, isoprenylation, and the C-terminal α-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2.	GBP2 GBP3	3.77e-05	3	124	2	20950129
Pubmed	Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.	RASGRF1 RASGRF2	3.77e-05	3	124	2	15029245
Pubmed	RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.	RAD54B RAD54L	3.77e-05	3	124	2	25765654
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR2	3.77e-05	3	124	2	9808793
Pubmed	Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.	GBP2 GBP3	3.77e-05	3	124	2	30062052
Pubmed	Effects of UPF1 expression on EMT process by targeting E‑cadherin, N‑cadherin, Vimentin and Twist in a hepatocellular carcinoma cell line.	UPF1 CDH1	3.77e-05	3	124	2	30628676
Pubmed	Oocytes mount a noncanonical DNA damage response involving APC-Cdh1-mediated proteolysis.	SETX CDH1	3.77e-05	3	124	2	32328643
Pubmed	Mammalian orthologues of a yeast regulator of nonsense transcript stability.	ACD UPF1	3.77e-05	3	124	2	8855285
Pubmed	Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.	GBP2 GBP3	3.77e-05	3	124	2	26416908
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR2	3.77e-05	3	124	2	18194433
Pubmed	Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.	GBP2 GBP3	3.77e-05	3	124	2	32354743
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR2	3.77e-05	3	124	2	27777977
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR2	3.77e-05	3	124	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR2	3.77e-05	3	124	2	18241669
Pubmed	Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.	GBP2 GBP3	3.77e-05	3	124	2	23248289
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR2	3.77e-05	3	124	2	19068129
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR2	3.77e-05	3	124	2	17327232
Cytoband	1p22.2	GBP2 GBP3 GBP5	6.00e-05	28	124	3	1p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr6q16	USP45 FBXL4 FUT9	4.80e-04	56	124	3	chr6q16
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR2	5.78e-05	3	80	2	297
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB3C MOB3B	4.00e-04	7	80	2	647
GeneFamily	Myosins, class I	MYO1G MYO1H	5.32e-04	8	80	2	1097
GeneFamily	UPF1 like RNA helicases	SETX UPF1	1.04e-03	11	80	2	1169
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	MYO1G SETX LONP2 GBP2 GBP3 ITGB2 ZBTB1 GLCCI1 ITPR1 ITPR2 SETD2 GBP5 UBR5 GLS SCAF11 EP300 PRRC2B IL7R ZNF292 SP140	1.81e-05	1492	122	20	M40023
Coexpression	GSE14415_ACT_TCONV_VS_ACT_NATURAL_TREG_DN	MPO GBP3 SIVA1 ATAD2 GBP5 CCZ1 RAD54L	2.06e-05	178	122	7	M2950
Coexpression	GSE6259_CD4_TCELL_VS_CD8_TCELL_DN	MYO1G DBNL CHD9 ITPR1 MOB3B EP300 IL7R	2.54e-05	184	122	7	M6739
Coexpression	GSE22886_NAIVE_CD4_TCELL_VS_12H_ACT_TH1_UP	MPO DENND2A SETX LONP2 EEF2 IL7R ZNF292	4.19e-05	199	122	7	M4521
Coexpression	GSE26351_WNT_VS_BMP_PATHWAY_STIM_HEMATOPOIETIC_PROGENITORS_UP	DCDC2 ITGB2 SSU72 GLS FUT9 MOB3B LY75	4.19e-05	199	122	7	M8477
Coexpression	BLANCO_MELO_HUMAN_PARAINFLUENZA_VIRUS_3_INFECTION_A594_CELLS_UP	RASGRF2 GBP3 GLCCI1 GBP5 BMPER HERC5 EPHA4	4.91e-05	204	122	7	M34006
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#5_top-relative-expression-ranked_1000	B3GALT1 USP45 IPO8 WDR31 KBTBD8 PPWD1 ZNF518A LMO7 GLS LY75 EPHA4 ZNF292	1.93e-05	492	118	12	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_1000_k5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	MPO SETX ATAD2 ZBTB1 ESCO1 ZNF518A NDC80 UBR5 FUT9 MOB3B SCAF11 POLQ	4.15e-05	532	118	12	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_200	DCDC2 GRB7 FREM1 GXYLT2 BMPER CDH1 EPHA4	5.60e-05	175	118	7	gudmap_kidney_P4_CapMesRenVes_Crym_200
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHAF1A RDM1 ATAD2 NDC80 RAD54B POLQ RAD54L	7.14e-07	179	124	7	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHAF1A RDM1 ATAD2 NDC80 RAD54B POLQ RAD54L	7.41e-07	180	124	7	f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD9 ESCO1 ITPR2 EEF2 SCAF11 BANK1 SP140	7.98e-07	182	124	7	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETX CHD9 RHOB SETD2 SCAF11 EP300 IL7R	8.58e-07	184	124	7	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MPO CHAF1A ATAD2 LMLN RAD54B POLQ RAD54L	8.90e-07	185	124	7	47c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCell	droplet-Fat-Scat-21m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C2CD4B RASGRF1 DBNL GRB7 FUT9 TMPRSS2 CDH1	9.23e-07	186	124	7	59710cff3f6f7c318ee2524b44c1a909f312c25e
ToppCell	droplet-Fat-Scat-21m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C2CD4B RASGRF1 DBNL GRB7 FUT9 TMPRSS2 CDH1	9.23e-07	186	124	7	de88fafac51049ec1920695844d8ce8057940272
ToppCell	droplet-Fat-Scat-21m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C2CD4B RASGRF1 DBNL GRB7 FUT9 TMPRSS2 CDH1	9.23e-07	186	124	7	7ff73ab8fed5da779ee9c7bd2e14a8363edb7509
ToppCell	facs-Thymus-nan-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAF1A SIVA1 ATAD2 NDC80 RAD54B POLQ RAD54L	1.27e-06	195	124	7	93c345e70d6c8ff5d12fd63d73228c1700b804a0
ToppCell	356C-Lymphocytic-NK_cells-Proliferating_NK_cell\|356C / Donor, Lineage, Cell class and subclass (all cells)	CHAF1A SIVA1 RDM1 ATAD2 NDC80 POLQ RAD54L	1.45e-06	199	124	7	e3b69608c834bd8ce6bedde298a2763cc0d7d573
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHD9 ITGB2 RHOB EEF2 SCAF11 BANK1	7.18e-06	166	124	6	063d68f2ffb40770cb4601fa1cb6426ae26f7a37
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHD9 ITGB2 RHOB EEF2 SCAF11 BANK1	7.18e-06	166	124	6	417cfb207da08fa1a0fd5f2a13c8786628667a8e
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHD9 ITGB2 RHOB EEF2 SCAF11 BANK1	7.18e-06	166	124	6	f28d07715e6b00ca2a0df39273c5f569744be5a8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHAF1A ATAD2 NDC80 RAD54B POLQ RAD54L	7.95e-06	169	124	6	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo-Cycling_T\|Lung / Manually curated celltypes from each tissue	CHAF1A RDM1 NDC80 RAD54B POLQ RAD54L	8.51e-06	171	124	6	976361f67dd725870e0513ae7a92f2dcaee17148
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-Cycling_NK\|bone_marrow / Manually curated celltypes from each tissue	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	9.09e-06	173	124	6	8a9dd85f718564c07cf3120ad648daeb60c94fc5
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G ITGB2 ADGRE1 BANK1 IL7R SP140	1.14e-05	180	124	6	83f9060dcf1d0ff8d2b2edc1841b2624b81c0eb3
ToppCell	(3)_Chondrocytes-(32)_Chondro-prehyper-2\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	DPYD RARRES1 FOXA3 GXYLT2 LMO7 EPHA4	1.14e-05	180	124	6	708a5c89b9337e281fce4f482892a1c1766c7812
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHAF1A ATAD2 NDC80 RAD54B POLQ RAD54L	1.14e-05	180	124	6	401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell	NS-moderate-d_0-4-Lymphoid-CTL\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MYO1G RASGRF2 KBTBD8 GBP5 IL7R SP140	1.18e-05	181	124	6	7fb3c1d29c542a3cea7fa654432d501d82df138f
ToppCell	droplet-Heart-4Chambers-21m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 WDR31 DBNL GRB7 TMPRSS2 CDH1	1.18e-05	181	124	6	3fd16229a63de0971db5d48860c01173d7db518f
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHAF1A KBTBD8 ATAD2 NDC80 LY75 POLQ	1.21e-05	182	124	6	21dcab170ffeef89faa9fee5008568cb6e15c694
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G ITGB2 ADGRE1 BANK1 IL7R SP140	1.21e-05	182	124	6	cf32603ad9b9882b0bb873327d58b50dd26a5bd3
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO CHAF1A ATAD2 RAD54B POLQ RAD54L	1.21e-05	182	124	6	11494a66d986297b837332ee9d382b71b9f22591
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G ITGB2 ADGRE1 BANK1 IL7R SP140	1.21e-05	182	124	6	71cfd0b6d464e3e1b1cca34f423abdf699cda48a
ToppCell	droplet-Spleen-nan-18m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESCO1 ITPR2 EEF2 SCAF11 BANK1 SP140	1.25e-05	183	124	6	28cbf909424f3be4491d49832f0aca0386560814
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	GBP2 GBP3 CHD9 SETD2 HERC5 ZNF292	1.25e-05	183	124	6	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	COVID-19-kidney-CD-IC-A\|kidney / Disease (COVID-19 only), tissue and cell type	GLCCI1 FREM1 ITPR2 LMO7 TMPRSS2 CDH1	1.25e-05	183	124	6	5c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MPO CHAF1A ATAD2 RAD54B POLQ RAD54L	1.25e-05	183	124	6	6c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESCO1 ITPR2 EEF2 SCAF11 BANK1 SP140	1.25e-05	183	124	6	3fa608aa6b119869ec3280dc388dfee57160e63a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A FBXL4 ITPR1 LMO7 MOB3B NOS1	1.41e-05	187	124	6	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.41e-05	187	124	6	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DCDC2 GLCCI1 LMO7 GLS TMPRSS2 CDH1	1.46e-05	188	124	6	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	GBP2 GBP3 GBP5 IL7R HERC5 SP140	1.46e-05	188	124	6	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A GLCCI1 FBXL4 CASD1 LMO7 NOS1	1.50e-05	189	124	6	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHAF1A ATAD2 NDC80 POLQ RAD54L HERC5	1.50e-05	189	124	6	fd8834d1feb7f63911c5fa51efb1f679a8baddeb
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PPWD1 ESCO1 SETD2 IL7R ZNF292 SP140	1.55e-05	190	124	6	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2A ITPR1 LMO7 PLAU NOS1 EPHA4	1.55e-05	190	124	6	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DPYD ITPR1 LMO7 GLS BMPER EPHA4	1.55e-05	190	124	6	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD9 ESCO1 ZNF518A ITPR2 SCAF11 CDH1	1.59e-05	191	124	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	DENND2A CHD9 VIT OPHN1 CATSPERB BMPER	1.59e-05	191	124	6	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD9 ESCO1 ZNF518A ITPR2 SCAF11 CDH1	1.59e-05	191	124	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	MON2 DCDC2 ITPR2 UBR5 SCAF11 ZNF292	1.64e-05	192	124	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	DENND2A RARRES1 VIT OPHN1 CATSPERB BMPER	1.64e-05	192	124	6	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DCDC2 GRB7 LMO7 FUT9 TMPRSS2 CDH1	1.64e-05	192	124	6	1aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-Cycling_T\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	RDM1 ATAD2 NDC80 POLQ RAD54L IL7R	1.69e-05	193	124	6	81e6240cffb094b2aa3684fd0889b6497f47c4f0
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	MON2 DCDC2 ITPR2 UBR5 SCAF11 ZNF292	1.69e-05	193	124	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.74e-05	194	124	6	f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCell	Control-Lymphoid_T/NK-T/NK_proliferative\|Control / Disease group, lineage and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.74e-05	194	124	6	9bbb124001fba7450f4639f47f9b720a483e7242
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DCDC2 GRB7 LMO7 FUT9 TMPRSS2 CDH1	1.74e-05	194	124	6	acd5ba9a097595d4caab4f05440531c65a4aa7bc
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.74e-05	194	124	6	a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.74e-05	194	124	6	17744fd6645cf5a447a01a83f07e8d305c2bcd9c
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.74e-05	194	124	6	e14f66f7584909621b776292fbd52808273fd2ee
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DCDC2 GRB7 LMO7 TMPRSS2 CATSPERB CDH1	1.79e-05	195	124	6	d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DCDC2 GLCCI1 LMO7 TMPRSS2 CATSPERB CDH1	1.79e-05	195	124	6	d673f8844896d5c7b76a7bc7f6b88a039f1bc263
ToppCell	COVID-19-kidney-Proliferating_T_cell\|kidney / Disease (COVID-19 only), tissue and cell type	MYO1G ATAD2 NDC80 POLQ RAD54L SP140	1.79e-05	195	124	6	7e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCell	PCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DCDC2 GRB7 LMO7 FUT9 TMPRSS2 CDH1	1.79e-05	195	124	6	b78db0d929be6b04055805ea5ffecc56c47ba956
ToppCell	PCW_10-12-Epithelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DCDC2 GRB7 LMO7 TMPRSS2 CATSPERB CDH1	1.85e-05	196	124	6	9bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DCDC2 RASGRF1 GRB7 TMPRSS2 CATSPERB CDH1	1.85e-05	196	124	6	0a34a0009f479384f1994c6f977f942699a132c8
ToppCell	Control-T/NK_proliferative\|Control / Disease condition and Cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.85e-05	196	124	6	7b7bc25aef49bfd64f79303a92d527bf8188f7a6
ToppCell	COVID-19-kidney-Macrophages\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DPYD DCSTAMP ITGB2 ZNF804A ITPR2 GBP5	1.90e-05	197	124	6	3912301018d0863144dcfac8d1fa8adc081748d7
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RDM1 ATAD2 NDC80 GBP5 POLQ RAD54L	1.90e-05	197	124	6	7eb4c1cffd0366204af7e63adc8f751685601a94
ToppCell	Control_saline-Epithelial_alveolar-AT_2\|Control_saline / Treatment groups by lineage, cell group, cell type	DCDC2 GRB7 GXYLT2 LMO7 TMPRSS2 CDH1	1.90e-05	197	124	6	b8f62fcd6eb8f47b3cc41f616126f82c68a36e87
ToppCell	COVID-19_Moderate-T/NK_proliferative\|COVID-19_Moderate / disease group, cell group and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.95e-05	198	124	6	166c000fb0e19602ffdd8bf2b2f19be2c6df96a6
ToppCell	COVID-19_Moderate-T/NK_proliferative\|World / disease group, cell group and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.95e-05	198	124	6	bf0131fbca6032e1aab4aa807f8c1d3be689cb7f
ToppCell	medial-2-Hematologic-Proliferating_Macrophage\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RDM1 ATAD2 NDC80 POLQ RAD54L HERC5	1.95e-05	198	124	6	64a2bcf5a9ba66a4fe08fbde33f1886c136cde8f
ToppCell	medial-Hematologic-Proliferating_Macrophage-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RDM1 ATAD2 NDC80 POLQ RAD54L HERC5	1.95e-05	198	124	6	fcc14ac3eb5088b9d6cd6af5a34dee5b81c0ece8
ToppCell	distal-1-Hematologic-Proliferating_Macrophage\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RDM1 ATAD2 NDC80 POLQ RAD54L HERC5	1.95e-05	198	124	6	df3f5559ecd1f3cd1fd60e39dbad8741309e83a3
ToppCell	distal-Hematologic-Proliferating_Macrophage-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RDM1 ATAD2 NDC80 POLQ RAD54L HERC5	1.95e-05	198	124	6	2b0716e900bce54ad1825d6dcdaf4ebf31f355c4
ToppCell	COVID-19_Severe-T/NK_proliferative\|World / disease group, cell group and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	1.95e-05	198	124	6	48045689d0969ff0a14eee7086b8e19b0d6b6065
ToppCell	CV-Mild-1\|CV / Virus stimulation, Condition and Cluster	GBP2 GBP3 GBP5 IL7R HERC5 SP140	1.95e-05	198	124	6	4b078714c49e7befb7b113d72485e712236d35fa
ToppCell	medial-Hematologic-Proliferating_Macrophage\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	RDM1 ATAD2 NDC80 POLQ RAD54L HERC5	1.95e-05	198	124	6	da6963184c32761c896a9b91a5321ad84b583736
ToppCell	severe_influenza-T/NK_proliferative\|severe_influenza / disease group, cell group and cell class (v2)	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.01e-05	199	124	6	638b1491c47f2884daf1c1d38a779ad8e0f59c52
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.01e-05	199	124	6	36c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating-Cycling_Progenitors\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.01e-05	199	124	6	a99516a5760f49a69b0fe45a9b2316e393252966
ToppCell	COVID-19_Mild-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Mild / Disease group, lineage and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.01e-05	199	124	6	ddea0e5c1cb6a096ab8e09a8c3c37c1bff381d9c
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.01e-05	199	124	6	7beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP45 RASGRF2 ZBTB1 GBP5 GLS IL7R	2.01e-05	199	124	6	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	COVID-19_Severe-T/NK_proliferative\|COVID-19_Severe / disease group, cell group and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.01e-05	199	124	6	af78837f3a7641a5bd98765eef9cb4f86034048c
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Mild / Disease, condition lineage and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	6126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCell	Control-Control-Lymphocyte-T/NK-T/NK_proliferative\|Control / Disease, condition lineage and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	6cf63dd57f6bc0c42e7182322dd24ff9afbe9186
ToppCell	healthy_donor-Lymphocytic-Proliferative_Lymphocyte\|healthy_donor / Disease condition, Lineage, Cell class and subclass	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	e4eb915c29909cf8535a3603c68976545c05e54b
ToppCell	healthy_donor-Lymphocytic-Proliferative_Lymphocyte-\|healthy_donor / Disease condition, Lineage, Cell class and subclass	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	415e7556b5ac45688e2c6c30a52bd40e0eb27c7d
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-T/NK_proliferative\|Multiple_Sclerosis / Disease, condition lineage and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	7faf1e37364203a08d2b2544979e848b41e36b1c
ToppCell	3'_v3-Lung-Lymphocytic_NK-Cycling_NK\|Lung / Manually curated celltypes from each tissue	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	381bafdde6492f020ae93ab8fffa6215c631c570
ToppCell	356C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CHAF1A SIVA1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	5d11a2c0021805e78d97dc1638bf73ca1faede66
ToppCell	LAM-Myeloid-pMacrophage\|LAM / Condition, Lineage and Cell class	RDM1 ATAD2 NDC80 POLQ RAD54L HERC5	2.07e-05	200	124	6	7e233d037165c9d3607604aaaf0f368e266567d3
ToppCell	tumor_Lung-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	CHAF1A SIVA1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	a1ef1b4824b2d56f6b2af15d698f58fc5590c392
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CHAF1A ATAD2 NDC80 RAD54B POLQ RAD54L	2.07e-05	200	124	6	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	Biopsy_IPF-Immune-Proliferating_Macrophages\|Biopsy_IPF / Sample group, Lineage and Cell type	RDM1 ATAD2 NDC80 POLQ RAD54L HERC5	2.07e-05	200	124	6	8abb2c25422717e994468ac02d8260344341467f
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-T/NK_proliferative\|Leuk-UTI / Disease, condition lineage and cell class	CHAF1A RDM1 ATAD2 NDC80 POLQ RAD54L	2.07e-05	200	124	6	093e97395be23092229521cc55aaaee8befbc149
ToppCell	mild-T/NK_proliferative\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CHAF1A ATAD2 NDC80 RAD54B POLQ RAD54L	2.07e-05	200	124	6	63cc57b9331459efbb73051d174d198a3568b938
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GBP3 GBP5 RAD54B LY75 SP140	3.31e-05	131	124	5	308ddb7fe113eac5dbeb9cb0b688d9e09275ce5e
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GBP3 GBP5 RAD54B LY75 SP140	3.43e-05	132	124	5	06e7337de35bd7120655a22b6020604ad004c4e1
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	VIT GXYLT2 CILP2 TMPRSS2 CDH1	3.82e-05	135	124	5	4451c44f3ad788437f4e2ae81049fbbab53f967e
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	VIT GXYLT2 CILP2 TMPRSS2 CDH1	3.82e-05	135	124	5	45f67f33c8320d9fb6dbceae603b564f6a8ffd1e
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GBP2 GLCCI1 GBP5 MOB3C PNPLA3	4.70e-05	141	124	5	b5e85f89b930a0ec70cc95733c5ab76ac3e9497f
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MPO MYO1G ITGB2 SLC16A3 IL7R	6.11e-05	149	124	5	5a5e9660f7d9b527f50a92d94d4c0c8aedb82c0b
ToppCell	P28-Hematopoietic\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MYO1G ITGB2 ADGRE1 BANK1 IL7R	7.14e-05	154	124	5	13980ae1957b05350c11171c9c118decfe998d3d
ToppCell	E16.5-samps-Myeloid\|E16.5-samps / Age Group, Lineage, Cell class and subclass	MYO1G GBP3 ITGB2 ADGRE1 SP140	7.59e-05	156	124	5	c7c73cef5700b0ae75280e62c94728434c712537
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	CHD9 ATAD2 SETD2 NDC80 UBR5 RAD54B SCAF11 CDH1 EPHA4	6.43e-07	183	122	9	7498_DN
Drug	ICI182,780; Up 200; 1uM; PC3; HT_HG-U133A	NR2C2 DPYD PPWD1 ITGB2 ITPR1 FBXO38 SLC16A3 RECQL5 GLS	1.09e-06	195	122	9	6918_UP
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A	SETX CHD9 SETD2 NDC80 RAD54B EP300 ZNF292 NAA16	5.84e-06	180	122	8	4541_DN
Drug	CPG-oligonucleotide	SETX CHAF1A RDM1 FBH1 MORF4L1 RAD54B POLQ RAD54L	6.86e-06	184	122	8	ctd:C408982
Disease	LYMPHOMA, NON-HODGKIN, FAMILIAL	CASP10 RAD54B RAD54L	6.20e-07	5	118	3	605027
Disease	Lymphoma, non-Hodgkin, familial	CASP10 RAD54B RAD54L	6.20e-07	5	118	3	cv:C4721532
Disease	Non-Hodgkin lymphoma	CASP10 RAD54B RAD54L	6.20e-07	5	118	3	cv:C0024305
Disease	Hypoxic Brain Damage	ITPR1 ITPR2	1.59e-05	2	118	2	C1140716
Disease	Anoxic Encephalopathy	ITPR1 ITPR2	1.59e-05	2	118	2	C0003132
Disease	Brain Hypoxia	ITPR1 ITPR2	1.59e-05	2	118	2	C1527348
Disease	Anoxia of brain	ITPR1 ITPR2	1.59e-05	2	118	2	C0995195
Disease	Benign neoplasm of stomach	CASP10 UBR5 CDH1	4.07e-05	17	118	3	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	CASP10 UBR5 CDH1	4.07e-05	17	118	3	C0496905
Disease	Carcinoma in situ of stomach	CASP10 UBR5 CDH1	4.07e-05	17	118	3	C0154060
Disease	non-Hodgkin lymphoma (is_implicated_in)	CASP10 RAD54B RAD54L	4.07e-05	17	118	3	DOID:0060060 (is_implicated_in)
Disease	lifestyle measurement	DPYD IPO8 ZNF804A GLCCI1 FREM1 CFAP74 EPHA4	4.63e-05	235	118	7	EFO_0010724
Disease	thrombin activatable fibrinolysis inhibitor activation peptide measurement	OTOA KBTBD8 ITPR1	5.77e-05	19	118	3	EFO_0008582
Disease	Lymphoma, Diffuse	CASP10 RAD54B RAD54L	7.87e-05	21	118	3	C3714542
Disease	Stomach Carcinoma	CASP10 UBR5 CDH1	7.87e-05	21	118	3	C0699791
Disease	Low Grade Lymphoma (neoplasm)	CASP10 RAD54B RAD54L	7.87e-05	21	118	3	C0079747
Disease	Lymphoma, Intermediate-Grade	CASP10 RAD54B RAD54L	7.87e-05	21	118	3	C0079741
Disease	High Grade Lymphoma (neoplasm)	CASP10 RAD54B RAD54L	7.87e-05	21	118	3	C0079740
Disease	Diffuse Mixed-Cell Lymphoma	CASP10 RAD54B RAD54L	7.87e-05	21	118	3	C0079757
Disease	Lymphoma, Undifferentiated	CASP10 RAD54B RAD54L	7.87e-05	21	118	3	C0024306
Disease	Reticulosarcoma	CASP10 RAD54B RAD54L	7.87e-05	21	118	3	C0024302
Disease	Lymphoma, Mixed-Cell	CASP10 RAD54B RAD54L	7.87e-05	21	118	3	C0024304
Disease	Lymphoma, Non-Hodgkin, Familial	CASP10 RAD54B RAD54L	9.08e-05	22	118	3	C4721532
Disease	Lymphoma, Small Noncleaved-Cell	CASP10 RAD54B RAD54L	9.08e-05	22	118	3	C0079770
Disease	Alzheimer disease type 1	MPO PLAU	9.46e-05	4	118	2	cv:C1863052
Disease	ALZHEIMER DISEASE, FAMILIAL, 1	MPO PLAU	9.46e-05	4	118	2	104300
Disease	Alzheimer's disease 1 (is_implicated_in)	MPO PLAU	9.46e-05	4	118	2	DOID:0080348 (is_implicated_in)
Disease	Stomach Neoplasms	DPYD RARRES1 CASP10 SLC16A3 UBR5 PLAU CDH1	1.98e-04	297	118	7	C0038356
Disease	Malignant neoplasm of stomach	DPYD RARRES1 CASP10 SLC16A3 UBR5 PLAU CDH1	2.11e-04	300	118	7	C0024623
Disease	viral load, disease progression measurement, CD4-positive T-lymphocyte count, HIV infection	DPYD IPO8	2.35e-04	6	118	2	EFO_0000764, EFO_0008336, EFO_0010105, EFO_0010125
Disease	Lymphoma, Non-Hodgkin	CASP10 RAD54B RAD54L	2.84e-04	32	118	3	C0024305
Disease	Early-onset autosomal dominant Alzheimer disease	MPO PLAU	3.29e-04	7	118	2	cv:CN043596
Disease	Alzheimer disease	MPO PLAU	4.37e-04	8	118	2	cv:C0002395
Disease	Endometrioma	NR2C2 DCSTAMP MED17 IL7R HERC5	4.84e-04	161	118	5	C0269102
Disease	Endometriosis	NR2C2 DCSTAMP MED17 IL7R HERC5	4.84e-04	161	118	5	C0014175
Disease	Alzheimer's disease (is_marker_for)	ITPR1 EEF2 PLAU NOS1 EP300 EPHA4	6.01e-04	257	118	6	DOID:10652 (is_marker_for)
Disease	alpha fetoprotein measurement	SETX CHD9 PNPLA3 POLQ	7.09e-04	100	118	4	EFO_0010583
Disease	Adenoid Cystic Carcinoma	SETD2 MORF4L1 CDH1 EP300	7.09e-04	100	118	4	C0010606
Disease	Pancreatic Neoplasm	DPYD PLAU CDH1 EP300	7.09e-04	100	118	4	C0030297
Disease	granulocyte percentage of myeloid white cells	MPO MYO1G CHD9 GLCCI1 SETD2 ZNF292	7.48e-04	268	118	6	EFO_0007997
Disease	Malignant neoplasm of pancreas	DPYD PLAU CDH1 EP300	7.64e-04	102	118	4	C0346647
Disease	Prostatic Neoplasms	MPO GRB7 FOXA3 ITPR1 SETD2 TMPRSS2 PLAU CDH1 ZNF292	8.46e-04	616	118	9	C0033578
Disease	Malignant neoplasm of prostate	MPO GRB7 FOXA3 ITPR1 SETD2 TMPRSS2 PLAU CDH1 ZNF292	8.46e-04	616	118	9	C0376358
Disease	urokinase-type plasminogen activator measurement	PLAU LY75	8.52e-04	11	118	2	EFO_0010803
Disease	urate measurement, bone density	NR2C2 GBP3 FREM1 FBXL4 ITPR1 ITPR2 GXYLT2 GBP5 PRRC2B	8.75e-04	619	118	9	EFO_0003923, EFO_0004531
Disease	neutrophil-to-lymphocyte ratio	MPO GRB7 ZBTB1 IL7R ZNF292	9.06e-04	185	118	5	EFO_0008447
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR2	1.02e-03	12	118	2	DOID:1441 (implicated_via_orthology)
Disease	rotator cuff tear	ZNF804A GLCCI1	1.02e-03	12	118	2	EFO_1001250
Disease	Hereditary Diffuse Gastric Cancer	DPYD RARRES1 CASP10 SLC16A3 PLAU CDH1	1.18e-03	293	118	6	C1708349
Disease	Mammary Carcinoma, Human	DPYD GRB7 SETD2 EEF2 SLC16A3 CDH1 EP300 RAD54L	1.26e-03	525	118	8	C4704874
Disease	Mammary Neoplasms, Human	DPYD GRB7 SETD2 EEF2 SLC16A3 CDH1 EP300 RAD54L	1.26e-03	525	118	8	C1257931
Disease	Mammary Neoplasms	DPYD GRB7 SETD2 EEF2 SLC16A3 CDH1 EP300 RAD54L	1.29e-03	527	118	8	C1458155
Disease	malignant pleural mesothelioma (is_marker_for)	SETD2 IL7R	1.40e-03	14	118	2	DOID:7474 (is_marker_for)
Disease	thyroid gland papillary carcinoma (is_marker_for)	PLAU CDH1	1.40e-03	14	118	2	DOID:3969 (is_marker_for)
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	1.40e-03	14	118	2	DOID:3753 (implicated_via_orthology)
Disease	Breast Carcinoma	DPYD GRB7 SETD2 EEF2 SLC16A3 CDH1 EP300 RAD54L	1.47e-03	538	118	8	C0678222
Disease	alcohol use disorder measurement	DPYD UNC5B ZNF804A BANK1 IL7R	1.73e-03	214	118	5	EFO_0009458
Disease	Sarcomatoid Renal Cell Carcinoma	GRB7 ZNF804A SETD2 EEF2	1.77e-03	128	118	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	GRB7 ZNF804A SETD2 EEF2	1.77e-03	128	118	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	GRB7 ZNF804A SETD2 EEF2	1.77e-03	128	118	4	C1266044
Disease	Papillary Renal Cell Carcinoma	GRB7 ZNF804A SETD2 EEF2	1.77e-03	128	118	4	C1306837
Disease	Renal Cell Carcinoma	GRB7 ZNF804A SETD2 EEF2	1.77e-03	128	118	4	C0007134
Disease	Schizoaffective disorder-bipolar type	MYO1G ZNF804A	1.83e-03	16	118	2	EFO_0009965
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	SETD2 EP300 IL7R	1.89e-03	61	118	3	C1961102
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	SETD2 ZNF292	2.07e-03	17	118	2	DOID:0060307 (is_implicated_in)
Disease	Ulcerative Colitis	MPO CDH1 IL7R	2.08e-03	63	118	3	C0009324
Disease	stomach cancer (is_marker_for)	SETD2 EEF2 NDC80 UBR5	2.58e-03	142	118	4	DOID:10534 (is_marker_for)
Disease	cortical surface area change measurement, age at assessment	VIT BMPER	2.59e-03	19	118	2	EFO_0008007, EFO_0021503
Disease	renovascular hypertension (biomarker_via_orthology)	MPO NOS1	2.59e-03	19	118	2	DOID:1591 (biomarker_via_orthology)
Disease	glomerulonephritis (is_marker_for)	MPO EP300	2.59e-03	19	118	2	DOID:2921 (is_marker_for)
Disease	congenital heart disease (implicated_via_orthology)	CHD9 ITPR1 NAA16	2.70e-03	69	118	3	DOID:1682 (implicated_via_orthology)
Disease	bipolar disorder, schizophrenia, response to lithium ion	MYO1H ZNF804A	2.87e-03	20	118	2	GO_0010226, MONDO_0004985, MONDO_0005090
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	GRB7 ZNF804A SETD2 EEF2	3.00e-03	148	118	4	C0279702
Disease	stomach cancer (is_implicated_in)	CASP10 EEF2 IL7R	3.04e-03	72	118	3	DOID:10534 (is_implicated_in)
Disease	BREAST CANCER	CDH1 RAD54L	3.17e-03	21	118	2	114480
Disease	myeloperoxidase (MPO)-DNA complex measurement	MPO CATSPERB	3.48e-03	22	118	2	EFO_0011039
Disease	prostate cancer (is_marker_for)	EEF2 PLAU CDH1 EP300	3.62e-03	156	118	4	DOID:10283 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLPQVKLFRPTFCLA	nan	106	Q75L30
KLPARPQVEKEFGFC	BANK1	766	Q8NDB2
FVKIQEPLFKQVARC	PPP2R5B	351	Q15173
GFIKCEKPFENDRPQ	FAM200B	71	P0CF97
CPVPFCLNIKQKLRQ	EP300	1801	Q09472
EVKLLPRKLQFFCDP	AGK	396	Q53H12
PRKLQFFCDPRKREQ	AGK	401	Q53H12
CEPKTANAFKPNILL	ARSD	31	P51689
DCREKVPRFKFPITQ	CATSPERB	936	Q9H7T0
LINEPNKCEKNIPFL	B3GALT1	66	Q9Y5Z6
NVAFSPLKRNCFIPK	DPYD	901	Q12882
PLFSCPDKNKVNFIP	GLCCI1	441	Q86VQ1
VFEKFKIQPPRGCLF	ATAD2	451	Q6PL18
CKDRPAFPVKKLIQA	CHAF1A	21	Q13111
TVVNVEKPPCFLRKF	DET1	51	Q7L5Y6
NKYLPPKIENVVFCR	RAD54B	536	Q9Y620
RKPFDVQREKPSNCA	NR2C2	191	P49116
TQIQECFLSPFRKPL	RAD54L	41	Q92698
QVQKLLNAFFDPKCP	OPHN1	416	O60890
VVKFLLEACKVNPFP	GLS	601	O94925
LANPPKKFRDCLFKV	ITPR2	46	Q14571
DPKPKFQEGERVLCF	MORF4L1	6	Q9UBU8
VPFPKNFLQICKKIL	MOB3B	141	Q86TA1
PLPKQSLKFFCALEV	RDM1	151	Q8NG50
FQPSAIKCLPDEIFK	OTOA	1051	Q7RTW8
CRFQIVQVLKEKPYP	LONP2	106	Q86WA8
LNNPPKKFRDCLFKL	ITPR1	46	Q14643
NFFCIRKKPKEPQPE	SLC16A3	406	O15427
NPFVFEVPSKEKLVC	FUT9	176	Q9Y231
RAVAVCNLQKFPKPL	LMLN	436	Q96KR4
FAKVLTPNRIPEFCI	C2CD4B	21	A6NLJ0
YKKCPLTVRNLAQFP	EPHA4	201	P54764
LPVFIKQLPFCRSNI	OR51E1	161	Q8TCB6
FPFVVKRLPFCKGNV	OR51I1	161	Q9H343
PRIKNQADCIPFFRS	MPO	301	P05164
DKFLRVNFSKGCPPL	NAA16	311	Q6N069
FRFLEEKGICNRPQP	PNPLA3	246	Q9NST1
FNISVFEPNCIPKPK	DCSTAMP	356	Q9H295
FFPESQLRAKLKCPG	FREM1	206	Q5H8C1
KKLFKPCAAQRLFLP	GXYLT2	186	A0PJZ3
RDPAPTNFPLKCQKQ	FAM157C	331	P0CG43
IGNSLEKFFQRCPKP	POU5F2	221	Q8N7G0
EKFFQRCPKPTPQQI	POU5F2	226	Q8N7G0
LPPEIQAKFLCVFER	LMO7	601	Q8WWI1
IPFQNKCFLKIKPVS	LY75	956	O60449
LGPKPQLAEVCAFFK	MIGA2	511	Q7L4E1
SFNDPRLCIRKFFPK	GBP2	216	P32456
NFNLPRLCIRKFFPK	GBP3	216	Q9H0R5
NFNLPRLCIQKFFPK	GBP5	216	Q96PP8
LCKKPRKNLNVSFNP	IL7R	286	P16871
FPRNQCKDLPKSDVL	MED17	596	Q9NVC6
CPLVIKLFSPNIKFR	MON2	276	Q7Z3U7
RKINSFFCDIPPLLA	OR5C1	176	Q8NGR4
SFLKIVPEPKQLECN	OVOS2	436	Q6IE36
PTDFGFCVKPNKLRN	GRB7	296	Q14451
CLKSNKIFKIPPQAF	LRRC66	201	Q68CR7
CIDPNPNFEKFLIKS	METTL7A	96	Q9H8H3
EKIPPQFAQAIAKSC	KBTBD8	251	Q8NFY9
DELRLPPCTIFQAFK	NOS1	1086	P29475
QPDCKIPLFLAFLVI	OR5H6	36	Q8NGV6
CNVANLPFPLALFKK	HERC5	781	Q9UII4
TKPQPFKDFLCISLR	FBXO38	221	Q6PIJ6
KECQPPFAFRHVLKL	ITGB2	196	P05107
IKCQLPKRFTAQGLP	UPF1	466	Q92900
FAPPLKDLCRFLKEN	CHD9	2576	Q3L8U1
SQRCIPEFFLAGKQP	FBH1	56	Q8NFZ0
CPKCLGQRKVFDLPF	BMPER	221	Q8N8U9
RPPVTLIQKLAACFF	CASD1	306	Q96PB1
SIDLQEPLQKKFCFP	GNE	376	Q9Y223
EPLQKKFCFPPVKEN	GNE	381	Q9Y223
KFCFPPVKENISQDI	GNE	386	Q9Y223
DQLKAIPQFCFPDAK	DENND2A	606	Q9ULE3
FKPCIKQINFPTNLI	FBXL4	191	Q9UKA2
NLKCFFENKRPDPFP	CALHM5	241	Q8N5C1
VFPLQREKCLNPFLG	POLQ	2211	O75417
DPDAKCRFPKIFVNT	CCZ1	291	P86791
DPDAKCRFPKIFVNT	CCZ1B	291	P86790
KLLNPKCRDVFEPAR	ADPRS	126	Q9NX46
FRFPQCVPINLKTLI	MAK	236	P20794
CPRLAEKPKLFFIQA	CASP10	386	Q92851
QCNRFFPSRKTKPVK	ESCO1	361	Q5FWF5
PRTFCQLILDPIFKV	EEF2	286	P13639
PAKATIFNLKCDPVF	EIF2A	296	Q9BY44
RAKDCKQNIPLPFLI	LINC01554	11	Q52M75
SPFVQPVCLPNIKFK	PRSS46P	141	E5RG02
ASCPIDRKPFQAVFK	SCAF11	76	Q99590
FLNAKRNKKPVQDCP	PRAMEF26	31	H0Y7S4
RFKVTFKNPQCPTLH	CFAP74	776	Q9C0B2
FRKPLQEPCTIFLIA	DCDC2	131	Q9UHG0
FCRVKDPNSGLPKFV	DBNL	66	Q9UJU6
FFCERNPKPQVINII	CDH1	601	P12830
VPFPKNFQQVCTKIL	MOB3C	141	Q70IA8
CYQILTDPNFDPRKK	IPO8	416	O15397
FCPNVPIILVANKKD	RHOB	106	P62745
KLRQSNPEFCPEKVA	TMEM248	296	Q9NWD8
PEELKFQCGQKTLRP	PLAU	161	P00749
RPVKQVRVQFCPFEK	MRPL53	11	Q96EL3
FKNLRETLKNCNPPA	RASGRF2	1136	O14827
FNDCFVKVARSPDKP	FOXA3	171	P55318
KLFPVECPKTVENFC	PPWD1	506	Q96BP3
FKRVLDNIKAVFPCP	POLR3A	921	O14802
PFAPKERCVKIFQGN	SNRNP40	266	Q96DI7
IIRNIKFKAPPCNTF	SETX	591	Q7Z333
RFKNLREALKNCDPP	RASGRF1	1171	Q13972
QKPSLEFKEFVGLPC	ACD	366	Q96AP0
LENIQPKQKFERPIC	ADGRE1	536	Q14246
PNPQEFRACFLKVKI	CILP2	931	Q8IUL8
KPVAIFKTPCFRANL	RECQL5	211	O94762
LQKPLTFNDLVKPVC	TMPRSS2	351	O15393
SPKVLFNQLCQKAPR	USP45	271	Q70EL2
VPVNEFNCPVTFCKK	ZNF292	676	O60281
RPKFTVPQINCDVKA	VIT	36	Q6UXI7
SRIPPRFAKKQNNLC	PRRC2B	1596	Q5JSZ5
PFSSKQLVKCPRRNQ	ZNF518A	1331	Q6AHZ1
KNKPVELRCRAFPAT	UNC5B	61	Q8IZJ1
FIVQCLNPYRKPDCK	SETD2	2481	Q9BYW2
QLGNFPEPLFDVCKK	ZBTB1	181	Q9Y2K1
QVCPEPIFRFFRENK	SP140	36	Q13342
CQLKQAPPQKVSFRF	WDR31	6	Q8NA23
CNFRQVEANPRKEPK	SMIM45	31	A0A590UK83
CSARVFFKNQKPRPT	RARRES1	126	P49788
FFKNQKPRPTINVTC	RARRES1	131	P49788
RNLASPNCVKPKIFF	PJA1	261	Q8NG27
FKPLGKVPCRFNISC	WDR87	101	Q6ZQQ6
CPFADVAPLQLKVRV	SIVA1	6	O15304
IKPRPERFQNCKDLF	SSU72	91	Q9NP77
NFIPQPIGKCKRVFQ	UBR5	1451	O95071
NFCKRQCEPFVPVLN	ZNF804A	416	Q7Z570
LASKEPFYVRCIKPN	MYO1G	591	B0I1T2
IKGFISRNKPLCPDN	MYO1H	761	Q8N1T3
KDPRPLNDKAFIQQC	NDC80	81	O14777