Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainKeratin_I

KRT27 KRT24

1.00e-0344202IPR002957
DomainFilament

KRT27 KRT24

2.59e-0371202SM01391
DomainIF

KRT27 KRT24

2.66e-0372202PS00226
DomainFilament

KRT27 KRT24

2.74e-0373202PF00038
DomainIF

KRT27 KRT24

2.96e-0376202IPR001664
DomainRING

MKRN4P ZNRF1 CHD3

4.00e-03305203SM00184
DomainZnf_RING

MKRN4P ZNRF1 CHD3

4.82e-03326203IPR001841
Pubmed

Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome.

MYOD1 HIC1

1.04e-06321210072440
Pubmed

Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.

HIC1 CHD3

5.20e-06621220547755
Pubmed

Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo.

MYOD1 MYH13

7.28e-06721219319192
Pubmed

Epaxial-adaxial-hypaxial regionalisation of the vertebrate somite: evidence for a somitic organiser and a mirror-image duplication.

MYOD1 HIC1

2.70e-051321211455436
Pubmed

Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis.

MYOD1 HIC1

4.15e-051621233482080
Pubmed

Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates.

MYOD1 MYH13

6.55e-052021219531352
Pubmed

TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.

MYOD1 HIC1

6.55e-052021236542062
Pubmed

Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.

MKRN4P NUFIP2

4.52e-045221226265008
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

RBM15 NUFIP2 MYH13

4.86e-0425821337794589
InteractionKRT4 interactions

KRT27 CHD3 KRT24

3.54e-0562213int:KRT4
InteractionKRT6C interactions

KRT27 CHD3 KRT24

6.53e-0576213int:KRT6C
InteractionKRT78 interactions

KRT27 CHD3 KRT24

9.77e-0587213int:KRT78
InteractionKRT3 interactions

KRT27 CHD3 KRT24

1.01e-0488213int:KRT3
InteractionMEGF6 interactions

CACNA1A NUFIP2

1.23e-0416212int:MEGF6
InteractionAARD interactions

KRT27 KRT24

1.39e-0417212int:AARD
InteractionEXOC3L1 interactions

KRT27 MYOD1

1.39e-0417212int:EXOC3L1
Cytoband4q23

DNAJB14 C4orf54

3.77e-05202124q23
CytobandEnsembl 112 genes in cytogenetic band chr4q23

DNAJB14 C4orf54

1.31e-0437212chr4q23
Cytoband17q21.2

KRT27 KRT24

4.72e-047021217q21.2
CytobandEnsembl 112 genes in cytogenetic band chr17p13

HIC1 CHD3 MYH13

5.10e-04346213chr17p13
CytobandEnsembl 112 genes in cytogenetic band chr17q21

KRT27 KRT24

1.95e-02473212chr17q21
GeneFamilyKeratins, type I

KRT27 KRT24

2.40e-0428152608
GeneFamilyRing finger proteins

MKRN4P ZNRF1

2.12e-0227515258
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT27 C4orf54 MYH13

7.58e-068221315bc417aaace2b1d680904a622fe76e95083c9ff
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT27 C4orf54 MYH13

7.58e-0682213697e1da3095c8483b8181b290fa5417bdc9cee54
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT27 C4orf54 MYH13

7.58e-068221373349906bcc8d1a40dc03df7a490a963e85564f2
ToppCellBAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 HIC1 BRSK1

6.25e-05166213bb93db4613c067c56614ab1ca39e73ee46484387
ToppCellBAL-Mild-Lymphocyte-T/NK-CD8+_T-MAIT|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNRF1 HIC1 BRSK1

6.25e-05166213c1f17a028bb27b8f202bcfffa7de7373b1cdd990
ToppCellCTRL-Myeloid-cDC|Myeloid / Disease state, Lineage and Cell class

ZNRF1 HIC1 CHD3

8.21e-05182213ee137574b8f0e684a4a7cb26226877c471cae433
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A GRIP2 BRSK1

9.03e-05188213ec0e241de2c8310b4417b9d4e2420d7a1662f1c0
ToppCellmLN-B_cell-B_cell_IgG_Plasma|B_cell / Region, Cell class and subclass

TMEFF1 ZNRF1 BRSK1

1.04e-04197213bd1d01d6c49f68f5c85d84df96c90dd04b9de09b
ToppCelldistal-1-Endothelial-Lymphatic|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

F2RL3 KRT27 HIC1

1.05e-04198213b6fea363463c8dd7e6780c085ece4900266a6286
Diseasemigraine disorder

MKRN4P CACNA1A AMBRA1

1.47e-03357193MONDO_0005277
Diseasestroke

C4orf54 CHD3

3.83e-03144192EFO_0000712

Protein segments in the cluster

PeptideGeneStartEntry
RGSDYDEADGPGSGG

CACNA1A

2411

O00555
PGSGGGEEAMAGAYD

CACNA1A

2421

O00555
GTAASGPGEGEGSEY

AMBRA1

1126

Q9C0C7
DGSGGRGDSGAYDGS

MKRN4P

56

Q13434
AASSAPGGGDGAEYK

RBM15

156

Q96T37
GPGAGGDGDDYKSSS

HIC1

386

Q14526
DVDGKSESSYSGGGG

NHSL1

536

Q5SYE7
ADAGSSGGTGPTEGY

FAM104A

6

Q969W3
PGRGGEHYSGDSDAS

MYOD1

186

P15172
PGSGDGGSGRDYSKY

KRT24

181

Q2M2I5
DGSCSKSKGYGGPGN

KRT27

396

Q7Z3Y8
YDESGSTGGGDDSTP

F2RL3

26

Q96RI0
GDGRYGSNDDPGSGM

CD99L2

166

Q8TCZ2
STSGSGEGGKGYTKD

DNAJB14

81

Q8TBM8
EKSESGGSEYGTGPG

CHD3

86

Q12873
MSSGAKEGGGGSPAY

BRSK1

1

Q8TDC3
GPYSKGGKDAGGADV

GRIP2

16

Q9C0E4
GKGPGSAYTDDGSET

C4orf54

776

D6RIA3
GYMGKGADNDGSGSE

NUFIP2

201

Q7Z417
YAGAETGDSGGSKKG

MYH13

626

Q9UKX3
LSTSGGSGYKNDGPG

ZCCHC18

321

P0CG32
GPCYSDNGSGSGEGE

TMEFF1

141

Q8IYR6
PGGGGSASDSTYAHG

ZNRF1

86

Q8ND25