Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalcohol binding

NPC1 NPC1L1 ITPR2

3.46e-04102273GO:0043178
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP6V0D2 ABCA13 ABCB5

4.21e-04109273GO:0042626
GeneOntologyCellularComponentlysosomal membrane

NPC1 TMEM106B ATP6V0D2 CUBN ABCA13

3.33e-04462285GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

NPC1 TMEM106B ATP6V0D2 CUBN ABCA13

3.33e-04462285GO:0098852
GeneOntologyCellularComponentvacuolar membrane

NPC1 TMEM106B ATP6V0D2 CUBN ABCA13

5.10e-04507285GO:0005774
GeneOntologyCellularComponentlysosome

NPC1 IFI30 TMEM106B ATP6V0D2 CUBN ABCA13

6.06e-04811286GO:0005764
GeneOntologyCellularComponentlytic vacuole

NPC1 IFI30 TMEM106B ATP6V0D2 CUBN ABCA13

6.06e-04811286GO:0000323
GeneOntologyCellularComponentendosome

NPC1 TMEM106B ATP6V0D2 CUBN GIT1 WDFY4 EXOC4

6.98e-041167287GO:0005768
GeneOntologyCellularComponentvacuole

NPC1 IFI30 TMEM106B ATP6V0D2 CUBN ABCA13

1.13e-03913286GO:0005773
GeneOntologyCellularComponentcytoplasmic vesicle membrane

NPC1 TMEM106B ATP6V0D2 CUBN ABCA13 NPC1L1 ITPR2

1.36e-031307287GO:0030659
GeneOntologyCellularComponentvesicle membrane

NPC1 TMEM106B ATP6V0D2 CUBN ABCA13 NPC1L1 ITPR2

1.47e-031325287GO:0012506
GeneOntologyCellularComponentcentrosome

WRAP73 ANKRD62 GIT1 PPP1R42 EXOC4

3.25e-03770285GO:0005813
DomainNPC1_N

NPC1 NPC1L1

2.17e-062282IPR032190
DomainNPC1_N

NPC1 NPC1L1

2.17e-062282PF16414
DomainNP_C_type

NPC1 NPC1L1

2.17e-062282IPR004765
DomainSterol-sensing

NPC1 NPC1L1

2.16e-055282PF12349
DomainPtc/Disp

NPC1 NPC1L1

7.75e-059282IPR003392
DomainPatched

NPC1 NPC1L1

7.75e-059282PF02460
DomainSSD

NPC1 NPC1L1

1.67e-0413282PS50156
DomainSSD

NPC1 NPC1L1

1.67e-0413282IPR000731
DomainABC_TRANSPORTER_2

ABCA13 ABCB5

2.34e-0348282PS50893
DomainABC_tran

ABCA13 ABCB5

2.34e-0348282PF00005
DomainABC_TRANSPORTER_1

ABCA13 ABCB5

2.44e-0349282PS00211
DomainABC_transporter-like

ABCA13 ABCB5

2.54e-0350282IPR003439
DomainARM-type_fold

USP34 WDFY4 ITPR2

1.39e-02339283IPR016024
DomainAAA+_ATPase

ABCA13 ABCB5

1.96e-02144282IPR003593
DomainAAA

ABCA13 ABCB5

1.96e-02144282SM00382
Pubmed

Human NPC1L1 and NPC1 can functionally substitute for the ncr genes to promote reproductive development in C. elegans.

NPC1 NPC1L1

6.25e-07228217662536
Pubmed

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins.

NPC1 NPC1L1

6.25e-07228232410728
Pubmed

Generation and function of astroglial lipoproteins from Niemann-Pick type C1-deficient mice.

NPC1 NPC1L1

6.25e-07228215544574
Pubmed

Presynaptic impairment in Niemann-Pick C1-deficient neurons: not dependent on presence of glial cells.

NPC1 NPC1L1

6.25e-07228221507342
Pubmed

Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain.

NPC1 NPC1L1

1.87e-06328216192643
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NPC1 USP34 MIA3 CUBN WDFY4 AHCTF1 NPAT

1.87e-05108428711544199
Pubmed

Defining the membrane proteome of NK cells.

NPC1 MIA3 EIF3H GIT1 IARS1 EXOC4 ITPR2

3.02e-05116828719946888
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

NPC1 IFI30 USP34 TMEM106B MIA3 ITPR2

3.28e-04120128635696571
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

USP34 TMEM106B MIA3 IARS1 AHCTF1 EXOC4

3.31e-04120328629180619
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

WRAP73 EIF3H GIT1 IARS1 RAD54B EXOC4

4.69e-04128428617353931
Pubmed

Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.

NPC1 CUBN

5.03e-044128219878569
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

NPC1 IARS1 NPC1L1

5.68e-0420228324639526
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

USP34 MIA3 ITPR2

6.54e-0421228333853758
CytobandEnsembl 112 genes in cytogenetic band chr7p21

TMEM106B ABCB5

1.36e-0389282chr7p21
GeneFamilyAnkyrin repeat domain containing

ANKRD62 GIT1

2.37e-02242182403
GeneFamilyWD repeat domain containing

WRAP73 WDFY4

2.75e-02262182362
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFI30 WDFY4 ABCA13 PPP1R42

2.67e-06156284c841faa1695ff577b0774f531adf1343d05dce9e
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFI30 WDFY4 ABCA13 PPP1R42

2.67e-0615628421baf8c6e62bb7fd1530c2c100f73c0cecee092e
ToppCellcontrol-Epithelial-Ionocyte|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ATP6V0D2 DMRT2 WDFY4 ITPR2

3.33e-061652845cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCellNS-control-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ATP6V0D2 DMRT2 WDFY4 ITPR2

3.41e-061662846d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCellcontrol-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ATP6V0D2 DMRT2 WDFY4 ITPR2

3.58e-06168284327b02f19f4a8607c033203824fdc60a1254331f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 ATP6V0D2 DMRT2 ITPR2

4.60e-06179284e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSIP2 ATP6V0D2 DMRT2 ITPR2

4.81e-061812842b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSIP2 ATP6V0D2 DMRT2 ITPR2

4.81e-061812846aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSIP2 ATP6V0D2 DMRT2 ITPR2

4.81e-0618128440df0afcb6848202da54670e84f22d7c3a515d01
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FSIP2 ATP6V0D2 DMRT2 ITPR2

4.81e-0618128440d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

NPC1 AHCTF1 EXOC4 ITPR2

5.36e-061862848571956890fc9894d766ba294a28e376b4aba428
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANKRD62 ATP6V0D2 DMRT2

1.10e-04149283cc911b454fe4e4b489885b9920baa7eb01a027ba
ToppCellIonocyte|World / shred by cell class for nasal brushing

ATP6V0D2 DMRT2 ITPR2

1.21e-041542836b78fb0c96fc7b5e901c39b3424f4aa8d0a6b9cf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.28e-04157283c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP6V0D2 CUBN WDFY4

1.31e-041582836811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCellIPF-Epithelial-Ionocyte|Epithelial / Disease state, Lineage and Cell class

ATP6V0D2 DMRT2 ITPR2

1.31e-0415828367adf625a959444762d32268b3b7441f6f8b3b8c
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IFI30 ATP6V0D2 WDFY4

1.33e-041592830c2437da5443fc3aff66f8ef311f02aa434a1fb0
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFI30 ATP6V0D2 ABCB5

1.33e-04159283d9e535cf9a0a2302268f2897b010dcecc6426e41
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFI30 ATP6V0D2 ABCB5

1.33e-0415928329999c87f5823f734e5cbf8ea8b729ec017db9b3
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFI30 ATP6V0D2 ABCB5

1.33e-041592834b840da854390f8285c219314cff4434d7ffcacc
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.35e-04160283174a4ab27114efcc63be36929b80680be3c35c9b
ToppCellPND01-03-samps-Myeloid-Macrophage-macrophage-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

IFI30 ATP6V0D2 WDFY4

1.38e-041612835925ee646aa040550e3f8a164a13c8a5c0353319
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

1.41e-041622839522af31f6b2f3cb81b6b84bd08353eea504d1d6
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

1.41e-041622839a18286e361e1dd18e6f943ce27db58b199fb6e4
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP6V0D2 CUBN WDFY4

1.41e-04162283d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

1.41e-0416228340265af9b36fd144a8577b8dacccd4fc0888a593
ToppCell3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

1.41e-041622833395e4dffdb9304d157c325e1fc0f12b433c7bd3
ToppCellPND01-03-samps-Myeloid-Macrophage|PND01-03-samps / Age Group, Lineage, Cell class and subclass

IFI30 ATP6V0D2 WDFY4

1.46e-0416428349733a9d3d95f05056b5b01916060ff20a8de3cf
ToppCellIonocyte|World / shred by cell class for turbinate

ATP6V0D2 DMRT2 ITPR2

1.48e-041652830cb2199b87f17ece743fb2652b2f448dfa78ae0b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD62 KRT40 ITPR2

1.48e-04165283fee7f2f8d0e25c0d067adc73f8913721bd709a3e
ToppCellPND01-03-samps-Myeloid|PND01-03-samps / Age Group, Lineage, Cell class and subclass

IFI30 ATP6V0D2 WDFY4

1.51e-0416628399dc8a186ec12d3563e81fa4618a814740332c73
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD62 KRT40 ITPR2

1.51e-04166283739dfbe927f409821ff23aca6e47ebe78f57e859
ToppCelldroplet-Lung-3m-Hematologic-myeloid|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IFI30 ATP6V0D2 WDFY4

1.54e-041672836f6f654d10cff83203415685f7707409626990ab
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.59e-041692834b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.59e-04169283a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.59e-041692832a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD62 KRT40 ITPR2

1.62e-0417028384d49a1f2989d98bd0acf9ec2d59f1042fc0f55b
ToppCelldroplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFI30 CUBN WDFY4

1.62e-0417028329deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCelldroplet-Thymus-nan-21m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFI30 CUBN WDFY4

1.62e-04170283dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCellNasal_Brush-Epithelial-Ionocytes|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

ATP6V0D2 DMRT2 ITPR2

1.68e-04172283dd3a23dc78dc6939f41126f8d7bd23a2e4713647
ToppCellNasal_Brush-Epithelial-Ionocytes|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ATP6V0D2 DMRT2 ITPR2

1.68e-0417228304fabb40fa9357d8902f3b04adc15231626cd9f8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.71e-041732830bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.73e-041742835f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.76e-041752831d8da48236549c01381f777ce5b2937f9f86acc2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.76e-0417528377c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IFI30 ATP6V0D2 WDFY4

1.79e-04176283e74ad0db3b05897edcfabeb11008ede2b9eeb638
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.79e-04176283c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IFI30 ATP6V0D2 WDFY4

1.79e-041762836548797336c9f4ca0f38e74a2c629e2a4defa252
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_CTXN3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD62 RAD54B ITPR2

1.82e-0417728396d639407f79669f3990138793d157b94273581c
ToppCellNS-moderate-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ATP6V0D2 DMRT2 ITPR2

1.82e-0417728399500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IFI30 ATP6V0D2 WDFY4

1.82e-0417728371919b5c9bfa87fdd2cd44dfa057b66ea081be5d
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

1.82e-041772836d89042bda8e244babb68929e84b25edcb545a77
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

1.82e-04177283daaccf1249dcf816df4caca695a944f53078291a
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

1.82e-04177283c5a16f984c836dbf7d0faf061677844167ab612a
ToppCell3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

1.82e-04177283338bdda26796bf4e16072878c070212d1006cf57
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IFI30 ATP6V0D2 WDFY4

1.89e-04179283ae9d90a4eac2cfa545a764df84914c5801544278
ToppCellNS-moderate-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ATP6V0D2 DMRT2 ITPR2

1.92e-041802838af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IFI30 ATP6V0D2 WDFY4

1.95e-04181283090e89b506d945e123e647d08947e9649a65ce7c
ToppCellNS-critical-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ATP6V0D2 DMRT2 ITPR2

1.95e-04181283cfc3ed541d93158ce26641ea30b7573d93600a11
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

1.95e-0418128330729f0364f719c044712a51453e22dc2c1a232b
ToppCellcellseq2-Immune-Immune_Myeloid-AM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IFI30 WDFY4 ABCB5

1.95e-04181283d4ab8ab41bf3e6f1937e919662456d7c9551eeab
ToppCellcellseq2-Immune-Immune_Myeloid-AM-AM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IFI30 WDFY4 ABCB5

1.95e-0418128345fc9c27ea60312a118a2a6c1eb635d776fde295
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ATP6V0D2 DMRT2 ITPR2

1.98e-041822836e7dac78dc030f74e546b9f6db07556e9bb13ac2
ToppCellcellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ATP6V0D2 DMRT2 ITPR2

1.98e-04182283cd972d30519db706477c6b0c901165b81b74abed
ToppCellPND10-Immune-Immune_Myeloid-Dendritic-cDC1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM106B WDFY4 RAD54B

2.01e-04183283ab38264daddccdf5ffb75ff2210b27423eca6bc0
ToppCellPND10-Immune-Immune_Myeloid-Dendritic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM106B WDFY4 RAD54B

2.01e-04183283e4911601dca2c0ecb448cdb6b222dedfc0c8bf6c
ToppCellCOVID-19-kidney-CD-IC-A|kidney / Disease (COVID-19 only), tissue and cell type

ATP6V0D2 DMRT2 ITPR2

2.01e-041832835c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCellPND10-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM106B WDFY4 RAD54B

2.01e-04183283263bfa1d8a7314bc3156c735c403c3bab8ea4dac
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

2.04e-04184283a60802e11dcc5f932811260b08a95a32f60f6b19
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

2.04e-0418428339c230d32e4259bc784e0edfd9e2884c96898564
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

2.04e-041842832a2fb691cc9414ef5b06c26239d2da03d6d7e5c2
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPC1 ATP6V0D2 DMRT2

2.08e-041852839438097e94219c1db922b8507e3a29106d32a923
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

NPC1 AHCTF1 EXOC4

2.08e-04185283a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA13 KRT40 ITPR2

2.08e-04185283686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

2.11e-04186283a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCellmoderate-Epithelial-Ionocyte|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ATP6V0D2 DMRT2 ITPR2

2.14e-041872833e3fe2d5712a0ac477cddefe56705d4b8d8f7eac
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP6V0D2 DMRT2 ITPR2

2.18e-041882831f912ea015f50570e848259d948a0ba682d64bb4
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

2.18e-04188283e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCellmoderate-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ATP6V0D2 DMRT2 ITPR2

2.21e-041892836011b747e27d61d222380a7bffdd921a68e9b657
ToppCellcritical-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ATP6V0D2 DMRT2 ITPR2

2.25e-0419028305a2c3549b68f49081723bf35db14974274419d5
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ATP6V0D2 DMRT2 ITPR2

2.28e-041912838f4637e801554e2343b974fe7794f01dd2151418
ToppCellMyeloid-Myeloid-B_(Activated_Macrophage)|Myeloid / shred on cell class and cell subclass (v4)

NPC1 ATP6V0D2 ITPR2

2.28e-041912837bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D175|Adult / Lineage, Cell type, age group and donor

ATP6V0D2 WDFY4 ABCB5

2.32e-04192283733491e932350e3c216a626cc49c3cd3fe970a82
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IFI30 WDFY4 ITPR2

2.35e-04193283697518bab1338dc441b2d93b410d957e692f20e6
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IFI30 ATP6V0D2 ITPR2

2.39e-0419428344a90be1d2b2ae08f8c523bee65dd1e536ec0f95
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP6V0D2 DMRT2 ITPR2

2.42e-04195283f7d9adadd37209ce1a38e5d621607b9c9270fed8
ToppCellproximal-Epithelial-Ionocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP6V0D2 DMRT2 ITPR2

2.50e-04197283e5d5accefaacea5ed2e22f906f5bcbc75083f287
ToppCellproximal-Epithelial-Ionocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP6V0D2 DMRT2 ITPR2

2.50e-04197283f65c35761da7c168d5c6e4d7edf5dafa26652fe4
ToppCellproximal-3-Epithelial-Ionocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP6V0D2 DMRT2 ITPR2

2.50e-04197283288492fc67d8e81349d38e82caf1f1890276b299
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IFI30 ATP6V0D2 WDFY4

2.54e-04198283243109377d62d20c69e9d1fedc252156e90cda1e
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

USP34 EXOC4 ITPR2

2.57e-0419928394b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellParenchymal-10x5prime-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IFI30 ATP6V0D2 ABCB5

2.57e-04199283f987f48970aec46156b80656e49b9f3604f3758c
ToppCell(07)_Ionocytes|World / shred by cell type by condition

ATP6V0D2 DMRT2 ITPR2

2.57e-041992838194777d367405a7840787e977854b5c07e3bd6b
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD62 KRT40 ITPR2

2.61e-04200283501cd2b4e55444fc5fdd93ebbcfc0616442b110b
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)---L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD62 KRT40 ITPR2

2.61e-04200283046a3a4d7e4d84ee4252a695ffd4a6aee8b77070
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)-|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD62 KRT40 ITPR2

2.61e-04200283893cc7f6b9794da90aa0c9d721b8647dc97201cd
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD62 KRT40 ITPR2

2.61e-042002833d677f13e429abc805a52ec2b8f36c703f511569
ToppCell390C-Myeloid-Dendritic|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

IFI30 EIF3H WDFY4

2.61e-042002833935b6ff3ae32d170a268538c756ee34ed2308d4
ToppCellNeuronal-Excitatory-eE(FEZF2_SLC17A7)-eE_1(EFTUD1P1)--|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD62 KRT40 ITPR2

2.61e-0420028312518f4a8d01fc66b72878cdf0ba124b37cff3d8
ToppCellBronchus_Control_(B.)-Immune-TX-DCs|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

IFI30 WDFY4 ITPR2

2.61e-04200283e0beacb88bbdc353a3e883171613027feafcf1ef
DrugAC1MM84Q

NPC1 IFI30 NPAT

8.68e-0634273CID003256860
Drugo-chloromercuriphenol

NPC1 NPC1L1

1.35e-055272CID000006999
DiseaseNiemann-Pick disease type C1 (implicated_via_orthology)

NPC1 NPC1L1

8.06e-072272DOID:0070113 (implicated_via_orthology)
DiseaseNiemann-Pick disease (implicated_via_orthology)

NPC1 NPC1L1

4.83e-064272DOID:14504 (implicated_via_orthology)
Diseasetrimethylamine-N-oxide measurement

CUBN ITPR2

7.29e-0514272EFO_0010541
Diseasedigestive system infectious disorder

NPC1 ITPR2

2.59e-0426272MONDO_0043424
DiseaseColorectal Carcinoma

EIF3H CUBN ABCA13 ABCB5 EXOC4

3.93e-04702275C0009402
Diseaserectum cancer

EIF3H WDFY4

6.79e-0442272EFO_1000657
Diseasehealth study participation

NPC1 IFI30 EXOC4

7.40e-04195273EFO_0010130
DiseaseAlzheimer disease, educational attainment

NPC1 MRPS30 EXOC4

1.46e-03247273EFO_0011015, MONDO_0004975
DiseaseColorectal Neoplasms

EIF3H ABCA13 ABCB5

2.03e-03277273C0009404
Diseaseurate measurement, bone density

FSIP2 ABCB5 AHCTF1 ITPR2

2.29e-03619274EFO_0003923, EFO_0004531
Diseaseschizophrenia, intelligence, self reported educational attainment

NPC1 MRPS30 EXOC4

3.79e-03346273EFO_0004337, EFO_0004784, MONDO_0005090
Diseaseeosinophil measurement

IFI30 USP34

4.39e-03108272EFO_0803540
Diseaseage at first sexual intercourse measurement

MRPS30 RAD54B EXOC4

5.04e-03383273EFO_0009749
Diseasemood instability measurement

TMEM106B EXOC4

6.10e-03128272EFO_0008475
Diseasechronotype measurement

NPC1 USP34 EXOC4 CCDC87

8.05e-03882274EFO_0008328
Diseasecardiovascular disease

NPC1 USP34 NPC1L1

8.19e-03457273EFO_0000319

Protein segments in the cluster

PeptideGeneStartEntry
SLLIAGQINTYCQNI

EIF3H

316

O15372
LISGCLVQTNTTNYQ

ABCB5

76

Q2M3G0
LFQLQSQNLLYQQQC

ANKRD62

776

A6NC57
NQLSFVNQTFLCLLS

ABCA13

3701

Q86UQ4
QLLTQQVIQCAYDIA

GIT1

731

Q9Y2X7
QCSNLNLNYLIQLSR

CCDC87

221

Q9NVE4
VSNYTQTLNILQEVC

RAD54B

666

Q9Y620
CLDRQYLAINQISTQ

ITPR2

741

Q14571
VLGYLQQENLISTCQ

NPAT

11

Q14207
TEAQYSSQLAQIQCL

KRT40

336

Q6A162
NTVLQELYVTNNCNL

FSIP2

2776

Q5CZC0
QIQSQAISYSGCLLQ

OR1G1

86

P47890
NTNCTILSVLNYFQN

NPC1

476

O15118
CINSLLQYFQNNRTL

NPC1L1

486

Q9UHC9
QLTSQDCTQNYLQLQ

CUBN

3326

O60494
CRNIFVLQQNLTNIT

EXOC4

871

Q96A65
YQQCLLNATTSVQAL

DMRT2

356

Q9Y5R5
EDQTQLLTLVCQLYQ

IFI30

216

P13284
QTIQSIQQCYLLLSN

AHCTF1

616

Q8WYP5
CYQLNTLALTTQADQ

MRPS30

371

Q9NP92
TIYLNITNTLNITNN

TMEM106B

141

Q9NUM4
NINALTNCITQLNLL

MIA3

1401

Q5JRA6
CISQITNLNYATNLT

PPP1R42

61

Q7Z4L9
VNTLQILQLYTCLDQ

WRAP73

36

Q9P2S5
SSTLLCQYINLQLLN

IARS1

1166

P41252
QNLSIIQYLQATDCV

WDFY4

251

Q6ZS81
LITNLISQYQNLQSD

USP34

3261

Q70CQ2
SLLTQQDYINLVQCE

ATP6V0D2

26

Q8N8Y2