Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLCO1B3 SLC25A21 CTNS SLC16A5 SLCO1B1 SLC37A4 SLC6A14	3.84e-06	293	45	7	GO:0008514
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLCO1B3 SLC25A21 CTNS SLC16A5 SLCO1B1 SLC37A4 SLC6A14	4.10e-06	296	45	7	GO:0015291
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLCO1B3 SLC25A21 CTNS SLC16A5 SLCO1B1 SLC6A14	6.71e-06	207	45	6	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLCO1B3 SLC25A21 CTNS SLC16A5 SLCO1B1 SLC6A14	6.90e-06	208	45	6	GO:0005342
GeneOntologyMolecularFunction	transporter activity	PEX1 SLCO1B3 SLC25A21 TMEM120A CTNS HTR3A SLC16A5 RASA3 SLCO1B1 SLC37A4 ATP10D SLC6A14	1.95e-05	1289	45	12	GO:0005215
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLCO1B3 SLC25A21 CTNS SLC16A5 SLCO1B1 SLC37A4 SLC6A14	8.79e-05	477	45	7	GO:0022804
GeneOntologyMolecularFunction	transmembrane transporter activity	SLCO1B3 SLC25A21 TMEM120A CTNS HTR3A SLC16A5 RASA3 SLCO1B1 SLC37A4 SLC6A14	2.39e-04	1180	45	10	GO:0022857
GeneOntologyMolecularFunction	prostaglandin transmembrane transporter activity	SLCO1B3 SLCO1B1	4.44e-04	14	45	2	GO:0015132
GeneOntologyMolecularFunction	icosanoid transmembrane transporter activity	SLCO1B3 SLCO1B1	5.12e-04	15	45	2	GO:0071714
GeneOntologyMolecularFunction	oligopeptide transmembrane transporter activity	SLCO1B3 SLCO1B1	5.84e-04	16	45	2	GO:0035673
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO1B3 SLCO1B1	7.43e-04	18	45	2	GO:0015347
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLCO1B3 SLC16A5 SLCO1B1	1.10e-03	90	45	3	GO:0008028
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	GBA2 EDEM2 KLB	1.62e-03	103	45	3	GO:0004553
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	CTNS SLC6A14	2.51e-03	33	45	2	GO:0072349
GeneOntologyMolecularFunction	bile acid transmembrane transporter activity	SLCO1B3 SLCO1B1	2.66e-03	34	45	2	GO:0015125
GeneOntologyMolecularFunction	steroid binding	NR3C2 STARD3NL PTCH1	3.34e-03	133	45	3	GO:0005496
GeneOntologyBiologicalProcess	organic anion transport	SLCO1B3 SLC25A21 CTNS SLC16A5 SLCO1B1 SLC37A4 SLC6A14	9.99e-05	515	44	7	GO:0015711
GeneOntologyBiologicalProcess	angiotensin maturation	ENPEP ATP6AP2	1.59e-04	9	44	2	GO:0002003
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by hormone	NR3C2 ENPEP ATP6AP2	1.76e-04	51	44	3	GO:0001990
GeneOntologyBiologicalProcess	carboxylic acid transport	SLCO1B3 SLC25A21 CTNS SLC16A5 SLCO1B1 SLC6A14	2.22e-04	410	44	6	GO:0046942
GeneOntologyBiologicalProcess	organic acid transport	SLCO1B3 SLC25A21 CTNS SLC16A5 SLCO1B1 SLC6A14	2.27e-04	412	44	6	GO:0015849
GeneOntologyBiologicalProcess	regulation of angiotensin levels in blood	ENPEP ATP6AP2	2.42e-04	11	44	2	GO:0002002
GeneOntologyBiologicalProcess	pigment catabolic process	SLCO1B3 SLCO1B1	2.42e-04	11	44	2	GO:0046149
GeneOntologyBiologicalProcess	heme catabolic process	SLCO1B3 SLCO1B1	2.42e-04	11	44	2	GO:0042167
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure mediated by a chemical signal	NR3C2 ENPEP ATP6AP2	2.99e-04	61	44	3	GO:0003044
GeneOntologyBiologicalProcess	porphyrin-containing compound catabolic process	SLCO1B3 SLCO1B1	3.42e-04	13	44	2	GO:0006787
GeneOntologyBiologicalProcess	tetrapyrrole catabolic process	SLCO1B3 SLCO1B1	3.98e-04	14	44	2	GO:0033015
GeneOntologyBiologicalProcess	carbohydrate metabolic process	CHST11 G6PC2 GBA2 SLC37A4 GNPTAB EDEM2 KLB	4.00e-04	646	44	7	GO:0005975
GeneOntologyBiologicalProcess	sodium-independent organic anion transport	SLCO1B3 SLCO1B1	4.59e-04	15	44	2	GO:0043252
GeneOntologyBiologicalProcess	monoatomic ion transport	SLCO1B3 NR3C2 TMEM120A CTNS HTR3A DMPK SLCO1B1 ATP6AP2 ATP10D SLC6A14	5.12e-04	1374	44	10	GO:0006811
GeneOntologyCellularComponent	endoplasmic reticulum membrane	NR3C2 POMT1 G6PC2 STARD3NL DMPK PTCHD3 GBA2 SLC37A4 ATP6AP2 ATP10D	3.45e-04	1293	45	10	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	NR3C2 POMT1 G6PC2 STARD3NL DMPK PTCHD3 GBA2 SLC37A4 ATP6AP2 ATP10D	3.58e-04	1299	45	10	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	NR3C2 POMT1 G6PC2 STARD3NL DMPK PTCHD3 GBA2 SLC37A4 ATP6AP2 ATP10D	4.24e-04	1327	45	10	GO:0042175
HumanPheno	Bilirubinuria	SLCO1B3 SLCO1B1	1.62e-05	2	21	2	HP:0031811
Domain	Desmoglein	DSG4 DSG1	3.24e-05	4	44	2	IPR009123
Domain	Desmosomal_cadherin	DSG4 DSG1	1.13e-04	7	44	2	IPR009122
Domain	MFS	SLCO1B3 SLC16A5 SLCO1B1 SLC37A4	1.20e-04	108	44	4	PS50850
Domain	Ptc/Disp	PTCH1 PTCHD3	1.93e-04	9	44	2	IPR003392
Domain	Patched	PTCH1 PTCHD3	1.93e-04	9	44	2	PF02460
Domain	MFS_dom	SLCO1B3 SLC16A5 SLCO1B1 SLC37A4	2.75e-04	134	44	4	IPR020846
Domain	OA_transporter	SLCO1B3 SLCO1B1	3.53e-04	12	44	2	IPR004156
Domain	OATP	SLCO1B3 SLCO1B1	3.53e-04	12	44	2	PF03137
Domain	SSD	PTCH1 PTCHD3	4.16e-04	13	44	2	PS50156
Domain	SSD	PTCH1 PTCHD3	4.16e-04	13	44	2	IPR000731
Domain	Cadherin_C	DSG4 DSG1	1.57e-03	25	44	2	PF01049
Domain	Cadherin_cytoplasmic-dom	DSG4 DSG1	1.57e-03	25	44	2	IPR000233
Domain	Catenin_binding_dom	DSG4 DSG1	2.11e-03	29	44	2	IPR027397
Domain	-	DSG4 DSG1	2.11e-03	29	44	2	4.10.900.10
Domain	Cadherin_CS	DSG4 FAT2 DSG1	2.15e-03	109	44	3	IPR020894
Domain	Cadherin	DSG4 FAT2 DSG1	2.38e-03	113	44	3	PF00028
Domain	CADHERIN_1	DSG4 FAT2 DSG1	2.38e-03	113	44	3	PS00232
Domain	CADHERIN_2	DSG4 FAT2 DSG1	2.44e-03	114	44	3	PS50268
Domain	-	DSG4 FAT2 DSG1	2.44e-03	114	44	3	2.60.40.60
Domain	CA	DSG4 FAT2 DSG1	2.51e-03	115	44	3	SM00112
Domain	Cadherin-like	DSG4 FAT2 DSG1	2.57e-03	116	44	3	IPR015919
Domain	Cadherin	DSG4 FAT2 DSG1	2.70e-03	118	44	3	IPR002126
Domain	Kazal_2	SLCO1B3 SLCO1B1	3.25e-03	36	44	2	PF07648
Domain	Pkinase_C	LATS2 DMPK	4.40e-03	42	44	2	PF00433
Domain	KAZAL	SLCO1B3 SLCO1B1	5.26e-03	46	44	2	SM00280
Domain	KAZAL_2	SLCO1B3 SLCO1B1	6.18e-03	50	44	2	PS51465
Domain	Kazal_dom	SLCO1B3 SLCO1B1	6.43e-03	51	44	2	IPR002350
Domain	AGC-kinase_C	LATS2 DMPK	7.71e-03	56	44	2	IPR000961
Domain	AGC_KINASE_CTER	LATS2 DMPK	7.71e-03	56	44	2	PS51285
Domain	S_TK_X	LATS2 DMPK	7.71e-03	56	44	2	SM00133
Pathway	REACTOME_ATORVASTATIN_ADME	SLCO1B3 SLCO1B1	2.65e-04	9	39	2	M45020
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO1B3 SLCO1B1	4.04e-04	11	39	2	M930
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO1B3 SLCO1B1	4.84e-04	12	39	2	MM15476
Pathway	WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS	SLCO1B3 SLCO1B1	4.84e-04	12	39	2	M48096
Pathway	WP_SULFATASE_AND_AROMATASE_PATHWAY	SLCO1B3 SLCO1B1	6.65e-04	14	39	2	M48085
Pathway	REACTOME_HEME_DEGRADATION	SLCO1B3 SLCO1B1	7.65e-04	15	39	2	M27060
Pathway	REACTOME_ATORVASTATIN_ADME	SLCO1B3 SLCO1B1	7.65e-04	15	39	2	MM15697
Pathway	REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS	ENPEP ATP6AP2	7.65e-04	15	39	2	MM14797
Pathway	WP_ACE_INHIBITOR_PATHWAY	NR3C2 ATP6AP2	9.88e-04	17	39	2	M39680
Pathway	REACTOME_METABOLISM_OF_ANGIOTENSINOGEN_TO_ANGIOTENSINS	ENPEP ATP6AP2	9.88e-04	17	39	2	M27104
Pathway	REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS	SLCO1B3 SLCO1B1	1.11e-03	18	39	2	M4862
Pathway	REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS	SLCO1B3 SLCO1B1	1.24e-03	19	39	2	MM14612
Pathway	REACTOME_HEME_DEGRADATION	SLCO1B3 SLCO1B1	1.37e-03	20	39	2	MM14721
Pubmed	Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	18314419
Pubmed	OATP 1B1/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	21691816
Pubmed	Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	28063966
Pubmed	Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	22240838
Pubmed	Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	29944058
Pubmed	Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	17412826
Pubmed	SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	36964102
Pubmed	Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	23340295
Pubmed	Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	29777022
Pubmed	Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	26191226
Pubmed	Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	22771883
Pubmed	Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	24194513
Pubmed	Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	18180273
Pubmed	Structure of human drug transporters OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	37723174
Pubmed	Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	24855184
Pubmed	Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	26474710
Pubmed	Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	25578040
Pubmed	Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	23670789
Pubmed	Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	24989890
Pubmed	Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	17496208
Pubmed	Rotor Syndrome	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	23236639
Pubmed	Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	27098745
Pubmed	Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	24740327
Pubmed	Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	21719246
Pubmed	Organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3: genetic variability and haplotype analysis in white Canadians.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	20877131
Pubmed	Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	16534140
Pubmed	UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	31299240
Pubmed	In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	23886114
Pubmed	OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	21787759
Pubmed	Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	1.64e-06	2	45	2	18321482
Pubmed	Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	31047942
Pubmed	Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	26146841
Pubmed	SLCO1B1, SLCO2B1, and SLCO1B3 polymorphisms and susceptibility to bladder cancer risk.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	24762081
Pubmed	Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	18296417
Pubmed	Interaction Between Sex and Organic Anion-Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib-N-Oxide and Regorafenib-Glucuronide in Mice.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	30955241
Pubmed	Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	20660695
Pubmed	Influence of drug formulation on OATP1B-mediated transport of paclitaxel.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	24755470
Pubmed	OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	29337310
Pubmed	Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	22136368
Pubmed	Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	31967785
Pubmed	Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	28013215
Pubmed	The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	19890249
Pubmed	HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	20051929
Pubmed	Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	19620935
Pubmed	Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	29422623
Pubmed	Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	24825069
Pubmed	Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	22695893
Pubmed	Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	18492796
Pubmed	Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	28389619
Pubmed	Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	26383540
Pubmed	Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	23986199
Pubmed	Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	18413659
Pubmed	Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	22203093
Pubmed	Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	20949553
Pubmed	Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake of Glucuronide Metabolites of Androgens.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	32587096
Pubmed	Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	26409184
Pubmed	Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	19400585
Pubmed	Synergistic interaction between genetics and disease on pravastatin disposition.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	24613363
Pubmed	OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	30218633
Pubmed	Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	25391605
Pubmed	Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1).	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	10833452
Pubmed	Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.	SLCO1B3 SLCO1B1	4.91e-06	3	45	2	10779507
Pubmed	Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.	SLCO1B3 SLCO1B1	9.81e-06	4	45	2	22294745
Pubmed	Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.	SLCO1B3 SLCO1B1	9.81e-06	4	45	2	20644253
Pubmed	Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.	SLCO1B3 SLCO1B1	9.81e-06	4	45	2	17906856
Pubmed	Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.	SLCO1B3 SLCO1B1	9.81e-06	4	45	2	21849517
Pubmed	Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.	SLCO1B3 SLCO1B1	9.81e-06	4	45	2	25280775
Pubmed	Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6.	DSG4 DSG1	9.81e-06	4	45	2	12787123
Pubmed	Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.	SLCO1B3 SLCO1B1	9.81e-06	4	45	2	19442037
Pubmed	Desmoglein as a target in skin disease and beyond.	DSG4 DSG1	9.81e-06	4	45	2	22189787
Pubmed	Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris.	DSG4 DSG1	9.81e-06	4	45	2	12705872
Pubmed	Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.	SLCO1B3 SLCO1B1	9.81e-06	4	45	2	27777271
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE LATS2 PTCH1 SLC16A5 ZNRF3 RASA3 GBA2 ARHGAP44 CCDC3	1.01e-05	1105	45	9	35748872
Pubmed	Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.	LATS2 PTCH1	1.63e-05	5	45	2	31474569
Pubmed	Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.	SLCO1B3 SLCO1B1	1.63e-05	5	45	2	38279097
Pubmed	OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.	SLCO1B3 SLCO1B1	1.63e-05	5	45	2	24194565
Pubmed	G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance.	G6PC2 SLC37A4	1.63e-05	5	45	2	27653037
Pubmed	Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk.	SLCO1B3 SLCO1B1	1.63e-05	5	45	2	20635135
Pubmed	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	SLCO1B3 SLCO1B1	2.45e-05	6	45	2	22232210
Pubmed	Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity.	SLCO1B3 SLCO1B1	2.45e-05	6	45	2	20212519
Pubmed	Analysis of DNA methylation and histone modification profiles of liver-specific transporters.	SLCO1B3 SLCO1B1	2.45e-05	6	45	2	19047482
Pubmed	Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.	SLCO1B3 SLCO1B1	4.56e-05	8	45	2	19129463
Pubmed	Pervasive translational regulation of the cell signalling circuitry underlies mammalian development.	LATS2 PTCH1	4.56e-05	8	45	2	28195124
Pubmed	Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers.	SLCO1B3 SLCO1B1	7.32e-05	10	45	2	18703564
Pubmed	Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.	DSG4 DSG1	7.32e-05	10	45	2	12724416
Pubmed	Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis.	CHST11 PTCH1	7.32e-05	10	45	2	16079159
Pubmed	Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients.	SLCO1B3 SLCO1B1	8.94e-05	11	45	2	18695635
Pubmed	Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.	SLCO1B3 SLCO1B1	8.94e-05	11	45	2	14579113
Pubmed	The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.	SLCO1B3 SLCO1B1	1.27e-04	13	45	2	11682476
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PRMT1 POMT1 SLC37A4 ATP6AP2 P3H4 GNPTAB TM9SF3 EDEM2	1.37e-04	1201	45	8	35696571
Pubmed	The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.	PIKFYVE PRMT1 PTCH1	1.92e-04	86	45	3	26885983
Pubmed	Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.	SLCO1B3 SLCO1B1	1.94e-04	16	45	2	35307651
Pubmed	Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity.	DSG4 DSG1	2.20e-04	17	45	2	18692037
Pubmed	Changes in thyroid status during perinatal development of MCT8-deficient male mice.	SLCO1B3 SLCO1B1	2.47e-04	18	45	2	23696569
Pubmed	Fgf21 regulates T-cell development in the neonatal and juvenile thymus.	ENPEP KLB	2.47e-04	18	45	2	28336912
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PIKFYVE FAT2 ZNF606 GBA2 GNPTAB	4.29e-04	493	45	5	15368895
Pubmed	Integral and associated lysosomal membrane proteins.	CTNS STARD3NL ENPEP	5.89e-04	126	45	3	17897319
Pubmed	JAWS coordinates chondrogenesis and synovial joint positioning.	CHST11 PTCH1	6.50e-04	29	45	2	18539921
Pubmed	Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.	DSG4 DSG1	6.96e-04	30	45	2	34905516
Pubmed	Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.	LATS2 PTCH1	7.43e-04	31	45	2	36362374
Interaction	ABHD3 interactions	RXFP1 HTR3A PTCHD3 GPR182	1.54e-07	22	45	4	int:ABHD3
Interaction	SYNGR2 interactions	RXFP1 SLCO1B1 ATP6AP2 GPR182	2.35e-05	75	45	4	int:SYNGR2
Interaction	DYM interactions	SLCO1B3 DSG4 SLCO1B1 GPR182	3.03e-05	80	45	4	int:DYM
Interaction	TAP2 interactions	RXFP1 HTR3A PTCHD3 GPR182	5.71e-05	94	45	4	int:TAP2
Cytoband	18q12.1	DSG4 DSG1	3.01e-04	26	45	2	18q12.1
GeneFamily	Solute carriers	SLCO1B3 SLC25A21 SLC16A5 SLCO1B1 SLC37A4 SLC6A14	4.85e-05	395	31	6	752
GeneFamily	Desmosomal cadherins	DSG4 DSG1	5.94e-05	7	31	2	1188
Coexpression	GSE7831_UNSTIM_VS_CPG_STIM_PDC_1H_DN	PEX1 PTCH1 ZNRF3 MIER1 EDEM2	2.35e-05	200	45	5	M6945
Coexpression	GUILLAUMOND_KLF10_TARGETS_DN	SLCO1B3 SLCO1B1 ENPEP	3.24e-05	36	45	3	MM953
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ROS1 NR3C2 SLC16A5 ZNRF3 SLC6A14 ARHGAP44	3.28e-08	186	45	6	acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ROS1 NR3C2 ZNRF3 SLC6A14 ARHGAP44	1.43e-06	192	45	5	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NR3C2 SLC16A5 SLC6A14 ARHGAP44	3.32e-05	181	45	4	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ROS1 NR3C2 ZNRF3 ARHGAP44	4.01e-05	190	45	4	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ROS1 NR3C2 ZNRF3 ARHGAP44	4.09e-05	191	45	4	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ROS1 NR3C2 ZNRF3 ARHGAP44	4.09e-05	191	45	4	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	ROS1 ZNRF3 SLC6A14 ARHGAP44	4.09e-05	191	45	4	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	ROS1 NR3C2 ZNRF3 ARHGAP44	4.18e-05	192	45	4	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ROS1 NR3C2 ZNRF3 ARHGAP44	4.18e-05	192	45	4	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	ROS1 NR3C2 ZNRF3 SLC6A14	4.18e-05	192	45	4	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ROS1 NR3C2 ZNRF3 SLC6A14	4.26e-05	193	45	4	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ROS1 NR3C2 ZNRF3 SLC6A14	4.26e-05	193	45	4	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	STARD3NL PTCH1 RASA3 GNPTAB	4.35e-05	194	45	4	a8dc3336aa4ef497f6d26cede02ddac425e7c655
Drug	demethylphalloin	SLCO1B3 DMPK SLCO1B1	2.51e-07	7	45	3	CID000114793
Drug	(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid	SLCO1B3 SLCO1B1	3.82e-06	2	45	2	ctd:C561635
Drug	rifamycin SV	SLCO1B3 SLCO1B1	2.29e-05	4	45	2	ctd:C023808
Drug	microcystin-LF	SLCO1B3 SLCO1B1	2.29e-05	4	45	2	ctd:C524165
Drug	Dihydromicrocystin Lr	SLCO1B3 SLCO1B1	2.29e-05	4	45	2	CID006441227
Drug	PHA-00846566E [724718-26-7]; Down 200; 10uM; PC3; HT_HG-U133A	NR3C2 CTNS POMT1 ZNF606 PTCH1	3.67e-05	191	45	5	7086_DN
Drug	2-propylpentanoic acid; Up 200; 1000uM; PC3; HT_HG-U133A	PEX1 CHST11 CTNS PTCH1 RASA3	3.76e-05	192	45	5	1209_UP
Drug	2,2',4,4',5,6'-hexabromodiphenyl ether	SLCO1B3 SLCO1B1	3.81e-05	5	45	2	ctd:C555859
Drug	Zuclopenthixol hydrochloride [633-59-0]; Up 200; 9.2uM; HL60; HT_HG-U133A	CTNS HTR3A SLC16A5 RASA3 ENPEP	4.46e-05	199	45	5	2936_UP
Drug	3alpha, 7beta-dihydroxy-5beta-cholan-24-oic acid	SLCO1B3 ROS1 NR3C2 SLCO1B1 GBA2	5.26e-05	206	45	5	CID000005645
Drug	trospium chloride	SLCO1B3 SLCO1B1	5.70e-05	6	45	2	ctd:C003330
Drug	prednisolone phosphate	SLCO1B3 SLCO1B1	5.70e-05	6	45	2	CID000004896
Drug	AC1L3M3Y	ROS1 GBA2 ATP6AP2	7.85e-05	42	45	3	CID000091455
Drug	liquiritin	HTR3A ENPEP	7.97e-05	7	45	2	CID000503737
Drug	21-deoxyaldosterone	NR3C2 CTNS	7.97e-05	7	45	2	CID000170778
Drug	nateglinide	SLCO1B3 SLCO1B1	7.97e-05	7	45	2	ctd:C060142
Drug	AC1L31WU	HTR3A DMPK	7.97e-05	7	45	2	CID000132964
Drug	BQ 123	SLCO1B3 SLCO1B1 GPR182	1.03e-04	46	45	3	CID000123632
Drug	TAK-875	SLCO1B3 SLCO1B1	1.06e-04	8	45	2	ctd:C557331
Drug	Fusidic Acid	SLCO1B3 SLCO1B1	1.06e-04	8	45	2	ctd:D005672
Drug	NSC263652	SLCO1B3 SLCO1B1	1.06e-04	8	45	2	CID000429721
Disease	Rotor syndrome	SLCO1B3 SLCO1B1	2.27e-06	2	45	2	cv:C0220991
Disease	HYPERBILIRUBINEMIA, ROTOR TYPE, DIGENIC	SLCO1B3 SLCO1B1	2.27e-06	2	45	2	C4016905
Disease	HYPERBILIRUBINEMIA, ROTOR TYPE	SLCO1B3 SLCO1B1	2.27e-06	2	45	2	237450
Disease	Rotor Syndrome	SLCO1B3 SLCO1B1	2.27e-06	2	45	2	C0220991
Disease	bilirubin metabolic disorder (implicated_via_orthology)	SLCO1B3 SLCO1B1	2.27e-05	5	45	2	DOID:2741 (implicated_via_orthology)
Disease	bilirubin metabolic disorder (is_implicated_in)	SLCO1B3 SLCO1B1	3.40e-05	6	45	2	DOID:2741 (is_implicated_in)
Disease	congenital disorder of glycosylation type II (is_implicated_in)	SLC37A4 ATP6AP2	4.75e-05	7	45	2	DOID:0050571 (is_implicated_in)
Disease	glycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement	GBA2 ATP10D	4.75e-05	7	45	2	EFO_0800551
Disease	glycosyl-N-behenoyl-sphingadienine (d18:2/22:0) measurement	GBA2 ATP10D	4.75e-05	7	45	2	EFO_0800520
Disease	deoxycholic acid glucuronide measurement	SLCO1B3 SLCO1B1	6.33e-05	8	45	2	EFO_0800575
Disease	hexadecenedioate (C16:1-DC) measurement	SLCO1B3 SLCO1B1	8.13e-05	9	45	2	EFO_0800562
Disease	X-21467 measurement	SLCO1B3 SLCO1B1	8.13e-05	9	45	2	EFO_0020007
Disease	glycochenodeoxycholate glucuronide (1) measurement	SLCO1B3 SLCO1B1	1.76e-04	13	45	2	EFO_0800474
Disease	Rolandic epilepsy	NR3C2 PTCHD3	2.69e-04	16	45	2	Orphanet_1945
Disease	ceramide measurement	SLCO1B3 SLCO1B1 GBA2 ATP10D	4.52e-04	235	45	4	EFO_0010222
Disease	aspartate measurement	ENPEP GNPTAB	6.14e-04	24	45	2	EFO_0010462
Disease	stroke outcome severity measurement	LATS2 PTCH1 SLCO1B1	7.08e-04	114	45	3	EFO_0009603
Disease	creatine measurement	SLCO1B3 ENPEP	1.39e-03	36	45	2	EFO_0010472

Protein segments in the cluster

Peptide	Gene	Start	Entry
PYFREFSMESSNYYA	HTR3A	216	P46098
SNMILYFFYKNVAYV	ATP10D	1111	Q9P241
DMTSKDYYFDSYAHF	PRMT1	46	Q99873
ASFKESYMATFYEFF	RASA3	531	Q14644
SYMATFYEFFNEQKY	RASA3	536	Q14644
VFNMVYFGFYYNVKN	SLC25A21	181	Q9BQT8
SYFSFMDDKDYYSLS	NR3C2	456	P08235
RHSEDMQFAFSYFYY	GNPTAB	986	Q3T906
LYYSFQDKDSLYFVM	LATS2	731	Q9NRM7
MAFLDSYFSEKAYAY	DSG4	776	Q86SJ6
AMFYHAYDSYLENAF	EDEM2	41	Q9BV94
AEFYYAFNTRSEMFA	FAT2	181	Q9NYQ8
TKSVFDYFEEYFAMN	ENPEP	326	Q07075
FAFQDENYLYLVMEY	DMPK	136	Q09013
MNFMESYFCQKAYAY	DSG1	691	Q02413
YYGQYISFYMKQIFF	POMT1	46	Q9Y6A1
AYKYNFEYSVVFNMV	ATP6AP2	296	O75787
DYHQYFSYNQMVASF	PIKFYVE	1366	Q9Y2I7
YSLYYFNRKTFSFVM	SLC37A4	21	O43826
YRMYNTYDVHFYASF	GBA2	531	Q9HCG7
QDYSYFFFLRMDENY	CCDC3	116	Q9BQI4
QKDYRAYYTFLNFMS	G6PC2	16	Q9NQR9
ETDEKDFYLYYFLMQ	DDX24	571	Q9GZR7
YATYCFQMFGDRVKY	KLB	221	Q86Z14
YFPQAYMNFYYKSTE	CTNS	281	O60931
SKFNMYRLYFGSSYE	PEX1	1121	O43933
MVYNQAFIYFDQYAA	PTCHD3	781	Q3KNS1
FYYMWKKSERYDFFA	MIER1	326	Q8N108
FSMYQSFVQFLQYYY	TMEM120A	226	Q9BXJ8
YFYFVNMYSSIFFLV	GPR182	131	O15218
IAAQFKYFSFYNMYI	PTCH1	791	Q13635
KYFSFYNMYIVTQKA	PTCH1	796	Q13635
MYSFVAKEIDYANYF	ARHGAP44	201	Q17R89
FFMGYYRYSKETNIN	SLCO1B1	116	Q9Y6L6
YEVYKLDFLMFNYSV	CHST11	331	Q9NPF2
YTFSNTFMEKLYPYF	TRIM69	466	Q86WT6
TNNFSYVFYMSSFFL	SLC16A5	391	O15375
KEVMQYDYYSSYFDI	STARD3NL	86	O95772
FVATMYHYLQFAYYK	P3H4	291	Q92791
DDNFYYQSMRYEVYQ	PSTK	151	Q8IV42
FTYVFKYMEQQYGQS	SLCO1B3	356	Q9NPD5
QFDKYFASYYKMTSQ	RXFP1	71	Q9HBX9
FASYYKMTSQYPFEA	RXFP1	76	Q9HBX9
EVSNFGYQMFYYSII	ROS1	1291	P08922
YYFFKTKMYGLFQTS	TM9SF3	536	Q9HD45
CFSQYETMYQHYYFQ	ZNRF3	461	Q9ULT6
IAYSLYYMFASFQSE	SLC6A14	136	Q9UN76
NYKEYENIFYFSSFM	ZNF606	346	Q8WXB4