Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	protein-DNA complex organization	KDM5B MLLT6 CDY2A JADE1 PER2 BCOR CABIN1 TDRD1 CENPF BAP1 TDRD12	5.73e-06	999	44	11	GO:0071824
GeneOntologyBiologicalProcess	chromatin organization	KDM5B MLLT6 CDY2A JADE1 PER2 BCOR CABIN1 TDRD1 BAP1 TDRD12	1.47e-05	896	44	10	GO:0006325
GeneOntologyBiologicalProcess	chromatin remodeling	KDM5B CDY2A JADE1 PER2 BCOR CABIN1 TDRD1 BAP1 TDRD12	2.18e-05	741	44	9	GO:0006338
GeneOntologyBiologicalProcess	regulation of glutamate uptake involved in transmission of nerve impulse	PER2 ITGB1	2.66e-05	4	44	2	GO:0051946
GeneOntologyBiologicalProcess	regulation of amino acid uptake involved in synaptic transmission	PER2 ITGB1	2.66e-05	4	44	2	GO:0051941
GeneOntologyBiologicalProcess	germ-line stem cell division	ZBTB16 TDRD12	6.64e-05	6	44	2	GO:0042078
GeneOntologyBiologicalProcess	glutamate reuptake	PER2 ITGB1	6.64e-05	6	44	2	GO:0051935
GeneOntologyBiologicalProcess	excretion	MLLT6 PSAP STC1	6.69e-05	37	44	3	GO:0007588
GeneOntologyBiologicalProcess	regulation of L-glutamate import across plasma membrane	PER2 ITGB1	1.98e-04	10	44	2	GO:0002036
GeneOntologyBiologicalProcess	amino acid neurotransmitter reuptake	PER2 ITGB1	1.98e-04	10	44	2	GO:0051933
GeneOntologyBiologicalProcess	developmental process involved in reproduction	KDM5B CDY2A ZBTB16 PSAP TDRD1 ADAM28 CRTAP TBC1D20 STC1 TDRD12	2.18e-04	1235	44	10	GO:0003006
GeneOntologyBiologicalProcess	siRNA-mediated heterochromatin formation	TDRD1 TDRD12	2.42e-04	11	44	2	GO:0141194
GeneOntologyBiologicalProcess	transposable element silencing by siRNA-mediated heterochromatin formation	TDRD1 TDRD12	2.42e-04	11	44	2	GO:0141007
GeneOntologyBiologicalProcess	NK T cell differentiation	ZBTB16 PSAP	3.98e-04	14	44	2	GO:0001865
Domain	COS_domain	TRIM63 TRIM54	3.53e-04	12	44	2	IPR017903
Domain	COS	TRIM63 TRIM54	3.53e-04	12	44	2	PS51262
Domain	Znf_FYVE_PHD	KDM5B MLLT6 JADE1 HGS	3.92e-04	147	44	4	IPR011011
Domain	Zinc_finger_PHD-type_CS	KDM5B MLLT6 JADE1	4.81e-04	65	44	3	IPR019786
Domain	TUDOR	TDRD1 TDRD12	4.85e-04	14	44	2	PF00567
Domain	-	TRIM63 TRIM54 KDM5B MLLT6 JADE1 HGS	6.08e-04	449	44	6	3.30.40.10
Domain	Znf_RING/FYVE/PHD	TRIM63 TRIM54 KDM5B MLLT6 JADE1 HGS	6.82e-04	459	44	6	IPR013083
Domain	PHD	KDM5B MLLT6 JADE1	7.32e-04	75	44	3	PF00628
Domain	Znf_PHD-finger	KDM5B MLLT6 JADE1	8.51e-04	79	44	3	IPR019787
Domain	BRCT	PARP4 REV1	9.04e-04	19	44	2	PF00533
Domain	PHD	KDM5B MLLT6 JADE1	1.20e-03	89	44	3	SM00249
Domain	EPHD	MLLT6 JADE1	1.22e-03	22	44	2	PS51805
Domain	BRCT	PARP4 REV1	1.22e-03	22	44	2	SM00292
Domain	Znf_PHD	KDM5B MLLT6 JADE1	1.28e-03	91	44	3	IPR001965
Domain	TUDOR	TDRD1 TDRD12	1.33e-03	23	44	2	PS50304
Domain	-	PARP4 REV1	1.33e-03	23	44	2	3.40.50.10190
Domain	ZF_PHD_2	KDM5B MLLT6 JADE1	1.45e-03	95	44	3	PS50016
Domain	ZF_PHD_1	KDM5B MLLT6 JADE1	1.50e-03	96	44	3	PS01359
Domain	BRCT	PARP4 REV1	1.70e-03	26	44	2	PS50172
Domain	BRCT_dom	PARP4 REV1	1.97e-03	28	44	2	IPR001357
Domain	Tudor	TDRD1 TDRD12	2.26e-03	30	44	2	IPR002999
Domain	Znf-RING_LisH	TRIM63 TRIM54	2.90e-03	34	44	2	IPR027370
Domain	zf-RING_UBOX	TRIM63 TRIM54	2.90e-03	34	44	2	PF13445
Pubmed	CEP152 is a genome maintenance protein disrupted in Seckel syndrome.	CEP152 CINP	1.64e-06	2	45	2	21131973
Pubmed	Genomic structure of the human BCCIP gene and its expression in cancer.	BCCIP DHX32	1.64e-06	2	45	2	12527204
Pubmed	New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.	TRIM63 TRIM54	1.64e-06	2	45	2	25801283
Pubmed	Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice.	CENPF RHOT1	4.91e-06	3	45	2	30856164
Pubmed	Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.	CENPF RHOT1	4.91e-06	3	45	2	26259702
Pubmed	Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.	TRIM63 TRIM54	4.91e-06	3	45	2	18222470
Pubmed	Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.	TRIM63 TRIM54	9.81e-06	4	45	2	17786241
Pubmed	Testicular expression of TDRD1, TDRD5, TDRD9 and TDRD12 in azoospermia.	TDRD1 TDRD12	9.81e-06	4	45	2	32059713
Pubmed	Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2.	BCCIP DHX32	9.81e-06	4	45	2	11313963
Pubmed	Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis.	KDM5B ZBTB16	9.81e-06	4	45	2	38287116
Pubmed	Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.	TRIM63 TRIM54	9.81e-06	4	45	2	11243782
Pubmed	A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate.	TRIM63 TRIM54 BAP1	1.40e-05	36	45	3	22626734
Pubmed	E3-ligase knock down revealed differential titin degradation by autopagy and the ubiquitin proteasome system.	TRIM63 TRIM54	2.45e-05	6	45	2	34702928
Pubmed	Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.	TRIM63 TRIM54	3.42e-05	7	45	2	11927605
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	TRIM63 TRIM54 PARP4 ZBTB16 PSAP ITGB1	4.20e-05	497	45	6	23414517
Pubmed	The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.	ITGB1 REV1	4.56e-05	8	45	2	10906324
Pubmed	Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration.	ITGB1 HGS	5.86e-05	9	45	2	26456826
Pubmed	Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover.	TRIM63 TRIM54	5.86e-05	9	45	2	21185285
Pubmed	Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse.	UTP6 RHOT1	1.27e-04	13	45	2	12696059
Pubmed	Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases.	TRIM63 TRIM54	1.94e-04	16	45	2	23695783
Pubmed	TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts.	MAP2K4 ITGB1	2.47e-04	18	45	2	23041440
Pubmed	Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.	TDRD1 TDRD12	4.44e-04	24	45	2	24067652
Pubmed	Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.	BCOR CENPF	4.82e-04	25	45	2	12522145
Pubmed	Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.	PTPRU ROR1	5.22e-04	26	45	2	36178190
Pubmed	DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells.	ZBTB16 TDRD1	6.06e-04	28	45	2	24850856
Pubmed	Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.	SECISBP2L RUBCNL	1.06e-03	37	45	2	12766061
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	MLLT6 JADE1 PSAP BCOR HGS	1.10e-03	608	45	5	16713569
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BCCIP MLLT6 BCOR CABIN1 BAP1	1.10e-03	608	45	5	36089195
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	PSAP ITGB1 CRTAP	1.26e-03	164	45	3	32409323
Cytoband	15q21.1	SECISBP2L CEP152	6.12e-04	37	45	2	15q21.1
Cytoband	17q11.2	UTP6 RHOT1	5.27e-03	110	45	2	17q11.2
GeneFamily	PHD finger proteins	KDM5B MLLT6 JADE1	3.57e-04	90	28	3	88
GeneFamily	Tudor domain containing	TDRD1 TDRD12	1.49e-03	37	28	2	780
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM63 TRIM54	9.45e-03	95	28	2	59
ToppCell	ICU-SEP-Lymphocyte-T_NK-MAIT\|ICU-SEP / Disease, Lineage and Cell Type	TRIM54 GPRASP1 DHX32 ZBTB16	2.26e-05	164	45	4	db863a44fc0dad5518c47fdbf64ea21d6f36f089
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPRASP1 ZBTB16 ITGB1 NDUFS5	2.97e-05	176	45	4	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	ICU-NoSEP-Myeloid-cDC1\|ICU-NoSEP / Disease, Lineage and Cell Type	TDRD1 ADAM28 RUBCNL ROR1	3.04e-05	177	45	4	33cd2c183ee8b597012efcbcae72131ac6beaf4e
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRIM63 TRIM54 POPDC2 ROR1	3.32e-05	181	45	4	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRIM63 TRIM54 POPDC2 ROR1	3.54e-05	184	45	4	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRIM63 TRIM54 POPDC2 ROR1	3.61e-05	185	45	4	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SECISBP2L ZBTB16 ADAM28 RUBCNL	3.85e-05	188	45	4	d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	TRIM63 TRIM54 POPDC2 CPEB4	4.01e-05	190	45	4	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	TRIM54 POPDC2 ROR1 CPEB4	4.26e-05	193	45	4	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM28 NDUFS5 ROR1 STC1	4.35e-05	194	45	4	fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM5B ZBTB16 PER2 ITGB1	4.35e-05	194	45	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CEP152 CENPF ADAM28 STC1	4.35e-05	194	45	4	590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	TRIM54 POPDC2 ROR1 CPEB4	4.44e-05	195	45	4	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	TRIM63 TRIM54 ROR1 CPEB4	4.44e-05	195	45	4	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	3'-GW_trimst-2\|3' / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIM63 PSAP ITGB1 ADAM28	4.71e-05	198	45	4	cf9861bc14737f2dc72e50222159e0180a6d3e5c
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-MAIT\|ICU-SEP / Disease, condition lineage and cell class	TRIM54 GPRASP1 DHX32 ZBTB16	4.80e-05	199	45	4	2f10622319c6146dfed8cfe3844180c1e1d56e94
Drug	(S)-propranolol hydrochloride [4199-10-4]; Down 200; 13.6uM; PC3; HT_HG-U133A	TRMU BCCIP CINP CABIN1 ROR1 STC1	2.46e-06	198	45	6	6343_DN
Disease	uroporphyrinogen-III synthase measurement	BCCIP DHX32	6.51e-06	3	44	2	EFO_0802205
Disease	uveal melanoma (is_marker_for)	KDM5B BAP1	7.77e-05	9	44	2	DOID:6039 (is_marker_for)
Disease	Seckel syndrome	CEP152 CENPF	4.93e-04	22	44	2	C0265202
Disease	Primary microcephaly	CEP152 RTTN	4.93e-04	22	44	2	C0431350
Disease	Malignant neoplasm of breast	DHX32 MAP2K4 PER2 CENPF OTOGL ROR1 BAP1	9.79e-04	1074	44	7	C0006142
Disease	Colonic Neoplasms	KDM5B PARP4 BAP1	1.52e-03	152	44	3	C0009375
Disease	Kidney Neoplasm	BCOR BAP1	1.64e-03	40	44	2	C0022665
Disease	Breast adenocarcinoma	MAP2K4 BAP1	1.72e-03	41	44	2	C0858252
Disease	Neoplasm of uncertain or unknown behavior of breast	MAP2K4 BAP1	1.72e-03	41	44	2	C0496956

Protein segments in the cluster

Peptide	Gene	Start	Entry
QYCSIKIVDILEEEV	TDRD1	406	Q9BXT4
LQICYIGDCEISVEL	ESYT3	191	A0FGR9
CEEEVLEVDNVKYCG	MLLT6	161	P55198
YNAIVLEECKALVRC	CDY2A	486	Q9Y6F7
VTAVQECYLEVCREK	CEP152	726	O94986
ECYLEVCREKDNLEL	CEP152	731	O94986
VCINAECVDIEKAYK	ADAM28	611	Q9UKQ2
LKCVEAEIANYEACL	BAP1	636	Q92560
VVFLACEQDIEKVCE	DHX32	276	Q7L7V1
CEQDIEKVCETVYQG	DHX32	281	Q7L7V1
EEVVLYCLENKICDV	BCOR	1476	Q6W2J9
EERAVEVACYVCKIL	MAP2K4	371	P45985
EICKCDVDEFVILEL	RUBCNL	296	Q9H714
TEEVEVILQYICECE	ITGB1	451	P05556
DKDCEDAYRVCQILD	TRMU	51	O75648
CVEQIQELVLRFCEK	BCCIP	141	Q9P287
AAIDVAECVYCENKE	PER2	1201	O15055
EIICDVVCLVYDVSN	RHOT1	486	Q8IXI2
ENLYVVEEKDLCAAC	LRRC18	196	Q8N456
EKEDYICVRCTVKDA	KDM5B	1526	Q9UGL1
CFLEVKEEDEIVCIQ	PARP4	1551	Q9UKK3
ECEGVVDIYNCVKTL	PTPRU	1106	Q92729
KEELETALEQCFYCL	CABIN1	936	Q9Y6J0
ICEILQAEKYELVTE	CENPF	1306	P49454
HYVEVLECKIQCEEN	CRTAP	266	O75718
EVKPYVLDDQLCDEC	CPEB4	656	Q17RY0
IQYLCEKDDVCVFQE	OTOGL	2106	Q3ZCN5
NIIQTYICKVCEETL	GPRASP1	1231	Q5JY77
LCLIDKIIEYLNECV	RTTN	871	Q86VV8
EERCCAVYEEAVKTL	UTP6	306	Q9NYH9
LKEYEQCIDILLERC	HPS3	901	Q969F9
TLEEGQVCVVYCEEL	TDRD12	56	Q587J7
CKIEYDDFVECLLRQ	NDUFS5	56	O43920
EYCNQVLCKEIDECV	SECISBP2L	676	Q93073
LGIEYDEDVVCDVCQ	JADE1	196	Q6IE81
IAEVQEECYSKLNVC	STC1	121	P52823
CLEYNEELEKLCEEL	CINP	81	Q9BW66
EDEKINIYCLTCEVP	TRIM63	126	Q969Q1
ECEILENVLCQTEYI	ROR1	251	Q01973
CEEHEEEKINIYCLS	TRIM54	126	Q9BYV2
AEILEIEYLEEQCLK	ZBTB16	106	Q05516
DILQVVKYCTDLIEE	REV1	1186	Q9UBZ9
EKEVRVCEPCYEQLN	HGS	206	O14964
YKEIVHCCEEQVLTL	POPDC2	126	Q9HBU9
SDVYCEVCEFLVKEV	PSAP	311	P07602
VIVLYREQEVLDCDC	TBC1D20	256	Q96BZ9
ERELVAVICPYCEKN	ZFAND1	71	Q8TCF1