Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabnormal pancreatic acinar cell morphology

SLC39A5 BHLHA15 NEUROG3

1.55e-0541173MP:0009146
MousePhenoabnormal pancreatic acinus morphology

SLC39A5 BHLHA15 NEUROG3

1.79e-0543173MP:0009145
MousePhenoabnormal exocrine pancreas morphology

SLC39A5 BHLHA15 NEUROG3

4.42e-0558173MP:0005220
MousePhenoabnormal pancreatic acinar cell zymogen granule morphology

BHLHA15 NEUROG3

1.87e-0417172MP:0009160
MousePhenoimpaired passive avoidance behavior

ADRA1B DISC1

7.63e-0434172MP:0004000
MousePhenoimpaired smooth muscle contractility

ADRA1B NRTN

8.09e-0435172MP:0000740
MousePhenoabnormal gland physiology

ADRA1B GFRA4 NRTN SLC39A5 BHLHA15

1.09e-03691175MP:0002164
MousePhenoimpaired avoidance learning behavior

ADRA1B DISC1

1.16e-0342172MP:0012312
MousePhenoincreased eosinophil cell number

FBXL19 PTGDR2 RNF19B

1.21e-03178173MP:0005011
Domain-

PAPPA AGRN

6.04e-03952322.60.120.200
Domain-

BHLHA15 NEUROG3

7.88e-031092324.10.280.10
DomainHLH

BHLHA15 NEUROG3

8.16e-03111232PF00010
DomainHLH

BHLHA15 NEUROG3

8.89e-03116232SM00353
DomainBHLH

BHLHA15 NEUROG3

9.03e-03117232PS50888
DomainbHLH_dom

BHLHA15 NEUROG3

9.18e-03118232IPR011598
Domain-

FBXL19 ZNRF3 RNF19B

1.71e-024492333.30.40.10
PathwayREACTOME_NCAM1_INTERACTIONS

GFRA4 NRTN AGRN

1.95e-0542183M7169
PathwayWP_NEUROGENESIS_REGULATION_IN_THE_OLFACTORY_EPITHELIUM

AGRN DISC1 NEUROG3

4.90e-0557183M48326
PathwayREACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH

GFRA4 NRTN AGRN

6.62e-0563183M11187
PathwayKEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG

BHLHA15 NEUROG3

4.54e-0425182M18312
PathwayREACTOME_RET_SIGNALING

GFRA4 NRTN

1.05e-0338182MM15493
PathwayREACTOME_RET_SIGNALING

GFRA4 NRTN

1.17e-0340182M27746
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

ADRA1B F2RL3 PTGDR2

1.59e-03186183MM15994
Pubmed

A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation.

GFRA4 NRTN

1.78e-05925210331972
Pubmed

Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo.

GFRA4 NRTN

2.22e-051025211069590
Pubmed

Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems.

GFRA4 NRTN

3.85e-051325222855506
Pubmed

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.

BHLHA15 NEUROG3

7.54e-051825212921743
Pubmed

Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice.

BHLHA15 NEUROG3

8.42e-051925219022256
Pubmed

Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).

BHLHA15 NEUROG3

9.35e-052025226752640
Pubmed

Mind bomb 1 is required for pancreatic β-cell formation.

BHLHA15 NEUROG3

1.36e-042425222529374
Pubmed

Hippo signaling regulates pancreas development through inactivation of Yap.

BHLHA15 NEUROG3

1.60e-042625223071096
Pubmed

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease.

BHLHA15 NEUROG3

1.99e-042925233527355
Pubmed

Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas.

BHLHA15 NEUROG3

2.28e-043125222178591
Pubmed

Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas.

BHLHA15 NEUROG3

2.74e-043425226771085
Pubmed

The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.

BHLHA15 NEUROG3

3.08e-043625225063451
Pubmed

Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6.

BHLHA15 NEUROG3

5.04e-044625223684747
GeneFamilyBasic helix-loop-helix proteins

BHLHA15 NEUROG3

5.27e-03110182420
CoexpressionGSE17721_0.5H_VS_12H_CPG_BMDC_DN

CCDC71L AGRN KMT5A RNF19B

3.60e-05199254M4122
CoexpressionGSE22935_WT_VS_MYD88_KO_MACROPHAGE_12H_MBOVIS_BCG_STIM_DN

CCDC71L ADRA1B PTGDR2 RNF19B

3.67e-05200254M7751
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Sst_(Reticular_formation)-|Thalamus / BrainAtlas - Mouse McCarroll V32

KCNS1 PAPPA F2RL3

1.26e-0581253e58f07266b7bad0af9a9856c678b4e0850c9f6c9
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Sst_(Reticular_formation)|Thalamus / BrainAtlas - Mouse McCarroll V32

KCNS1 PAPPA F2RL3

1.26e-0581253717751c7a6af08cec7d0e561869e4b292d1f83a5
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3|Thalamus / BrainAtlas - Mouse McCarroll V32

KCNS1 PAPPA F2RL3

1.30e-058225347b131333ab84b70d2abe3fc17e63de504214b1b
DrugDipyridamole [58-32-2]; Up 200; 8uM; MCF7; HT_HG-U133A

C10orf95 HRK DISC1 PTGDR2

5.73e-051952541517_UP
Drug3-nitropropionic acid; Down 200; 10uM; MCF7; HT_HG-U133A

KCNS1 NRTN DISC1 RNF19B

5.85e-051962546402_DN
DrugSulindac [38194-50-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A

HRK AGRN DISC1 GPATCH2L

5.85e-051962545528_DN
DrugBenfotiamine [22457-89-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A

C10orf95 KCNS1 HRK DISC1

5.96e-051972543837_DN
DrugMyosmine [532-12-7]; Up 200; 27.4uM; PC3; HT_HG-U133A

C10orf95 ADRA1B NRTN AGRN

6.08e-051982544293_UP
DrugGliquidone [33342-05-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A

C10orf95 HRK GPATCH2L RNF19B

6.20e-051992546004_DN
DrugBendroflumethiazide [73-48-3]; Up 200; 9.4uM; HL60; HT_HG-U133A

KCNS1 PAPPA PTGDR2 GPATCH2L

6.20e-051992542555_UP
DrugLomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; MCF7; HT_HG-U133A

KCNS1 HRK GPATCH2L RNF19B

6.20e-051992542310_DN
Diseasehippocampal CA1 volume

PAPPA HRK

6.41e-0448232EFO_0009394

Protein segments in the cluster

PeptideGeneStartEntry
QRRIRLLSRGPCGSR

AGRN

231

O00468
ARAAARAPGEGRRRR

BHLHA15

46

Q7RTS1
RILGCQCRGRGRRRR

ADRA1B

361

P35368
GRRRRRRRRRLGGCA

ADRA1B

371

P35368
AACFRRRRLARRPGY

DISC1

31

Q9NRI5
RGPGAGARRRRTRCR

FBXL19

26

Q6PCT2
GPSGRRPSARCARRR

KIAA1549

26

Q9HCM3
RPSARCARRRRPGLL

KIAA1549

31

Q9HCM3
RAGPRRRRARARLGA

NRTN

86

Q99748
RRRARARLGARPCGL

NRTN

91

Q99748
RRLGRRARCHGPGRA

KMT5A

31

Q9NQR1
EGGCRGAPRKLRARR

NEUROG3

51

Q9Y4Z2
LARYGAARCGRLRRR

KCNS1

191

Q96KK3
LARARGCPRGPRLLR

MROH6

671

A6NGR9
ALGCGLAERPRRARR

PAPPA

16

Q13219
RGRRRPGRFVRLVAA

PTGDR2

236

Q9Y5Y4
PLRARALRGRRLALG

F2RL3

181

Q96RI0
RRGDEARGAPCRRRR

BTBD19

261

C9JJ37
ARGAPCRRRRGTLPR

BTBD19

266

C9JJ37
RGLRSRASRCRPRSL

FAM189A2

311

Q15884
QGGCPRARCRRALRR

GFRA4

56

Q9GZZ7
PGAAARCLRKGRRRL

GPATCH2L

311

Q9NWQ4
PRAAARRRRRGARAA

CCDC71L

126

Q8N9Z2
RRRARSRRAPAPGAL

HRK

51

O00198
RDRQRLRFGPRRALA

RASL10A

131

Q92737
DPKCRSGGRRRRLTL

RNF19B

21

Q6ZMZ0
GLLRHRGLRPRCCRR

SLC39A5

306

Q6ZMH5
RDCRCRRPRRWPRAG

C10orf95

141

Q9H7T3
RRRLRRRPRGLRCSR

ZNRF3

16

Q9ULT6
RSPAVARRCGRPRRR

WWC2-AS2

81

Q96NR7