Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionMAP kinase kinase kinase activity

TAOK2 MAP3K19

5.61e-0427262GO:0004709
GeneOntologyMolecularFunctiondelayed rectifier potassium channel activity

KCNC1 KCNC3

6.04e-0428262GO:0005251
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

KLF18 EVX1 DLX6 ZNF875 AR EVX2 TBX2

1.73e-031412267GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

KLF18 EVX1 DLX6 ZNF875 AR EVX2 TBX2

2.10e-031459267GO:0000977
GeneOntologyCellularComponentaxolemma

KCNC1 KCNC3

3.32e-0421272GO:0030673
GeneOntologyCellularComponentcalyx of Held

KCNC1 KCNC3

9.85e-0436272GO:0044305
GeneOntologyCellularComponentneuronal cell body membrane

KCNC1 KCNC3

1.40e-0343272GO:0032809
GeneOntologyCellularComponentcell body membrane

KCNC1 KCNC3

1.68e-0347272GO:0044298
GeneOntologyCellularComponentdendrite membrane

KCNC1 KCNC3

2.37e-0356272GO:0032590
DomainK_chnl_volt-dep_Kv3

KCNC1 KCNC3

1.03e-054252IPR003974
DomainHTH_motif

EVX1 DLX6 EVX2

1.05e-0469253IPR000047
DomainHomeobox_metazoa

EVX1 DLX6 EVX2

2.30e-0490253IPR020479
DomainK_chnl_volt-dep_Kv

KCNC1 KCNC3

5.92e-0427252IPR003968
DomainVG_K_chnl

KCNC1 KCNC3

8.85e-0433252IPR028325
DomainHomeobox_CS

EVX1 DLX6 EVX2

1.90e-03186253IPR017970
DomainBTB_2

KCNC1 KCNC3

2.27e-0353252PF02214
DomainT1-type_BTB

KCNC1 KCNC3

2.27e-0353252IPR003131
DomainChannel_four-helix_dom

KCNC1 KCNC3

2.62e-0357252IPR027359
Domain-

KCNC1 KCNC3

2.62e-03572521.20.120.350
DomainHomeobox

EVX1 DLX6 EVX2

3.64e-03234253PF00046
DomainHOMEOBOX_1

EVX1 DLX6 EVX2

3.73e-03236253PS00027
DomainHOX

EVX1 DLX6 EVX2

3.78e-03237253SM00389
DomainHomeobox_dom

EVX1 DLX6 EVX2

3.87e-03239253IPR001356
DomainHOMEOBOX_2

EVX1 DLX6 EVX2

3.87e-03239253PS50071
Domain-

EVX1 DLX6 EVX2

6.19e-032832531.10.10.60
DomainHomeodomain-like

EVX1 DLX6 EVX2

9.58e-03332253IPR009057
DomainIon_trans_dom

KCNC1 KCNC3

1.01e-02114252IPR005821
DomainIon_trans

KCNC1 KCNC3

1.01e-02114252PF00520
DomainSer/Thr_kinase_AS

TAOK2 TAOK3 MAP3K19

1.17e-02357253IPR008271
DomainS_TKc

TAOK2 TAOK3 MAP3K19

1.18e-02359253SM00220
DomainPROTEIN_KINASE_ST

TAOK2 TAOK3 MAP3K19

1.21e-02362253PS00108
DomainProtein_kinase_ATP_BS

TAOK2 TAOK3 MAP3K19

1.37e-02379253IPR017441
DomainPkinase

TAOK2 TAOK3 MAP3K19

1.39e-02381253PF00069
DomainPROTEIN_KINASE_ATP

TAOK2 TAOK3 MAP3K19

2.27e-02459253PS00107
DomainBTB

KCNC1 KCNC3

2.40e-02180252SM00225
DomainBTB/POZ_dom

KCNC1 KCNC3

2.52e-02185252IPR000210
Pubmed

Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.

KCNC1 KCNC3

6.25e-07228233508244
Pubmed

Subcellular localization of the voltage-gated potassium channels Kv3.1b and Kv3.3 in the cerebellar dentate nucleus of glutamic acid decarboxylase 67-green fluorescent protein transgenic mice.

KCNC1 KCNC3

6.25e-07228218682278
Pubmed

Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3.3 channels in Kcnc3-null mice requires Kcnc1.

KCNC1 KCNC3

6.25e-07228220016089
Pubmed

Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo.

KCNC1 KCNC3

6.25e-07228218495891
Pubmed

Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.

KCNC1 KCNC3

6.25e-07228218448641
Pubmed

Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7.

EVX1 EVX2

6.25e-0722821684419
Pubmed

Motor dysfunction and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in mice lacking potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

6.25e-07228212930807
Pubmed

Increased motor drive and sleep loss in mice lacking Kv3-type potassium channels.

KCNC1 KCNC3

6.25e-07228215005717
Pubmed

Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms.

KCNC1 KCNC3

6.25e-07228216553620
Pubmed

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse.

KCNC1 KCNC3

6.25e-07228235510987
Pubmed

Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

6.25e-07228215217387
Pubmed

Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice.

KCNC1 KCNC3

6.25e-07228216923152
Pubmed

Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

6.25e-07228211517255
Pubmed

Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface.

KCNC1 KCNC3

6.25e-07228223734863
Pubmed

Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons.

KCNC1 KCNC3

1.87e-06328222673617
Pubmed

TAO kinases mediate activation of p38 in response to DNA damage.

TAOK2 TAOK3

1.87e-06328217396146
Pubmed

Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex.

EVX1 EVX2

3.75e-0642827579515
Pubmed

Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway.

AR CYP27A1

3.75e-06428221134350
Pubmed

Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.

KCNC1 KCNC3

3.75e-06428221912965
Pubmed

Localization of Shaw-related K+ channel genes on mouse and human chromosomes.

KCNC1 KCNC3

3.75e-0642828111118
Pubmed

Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.

TAOK2 TAOK3

6.24e-06528213679851
Pubmed

Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak.

EVX1 EVX2

6.24e-0652821349539
Pubmed

Location of preganglionic neurons is independent of birthdate but is correlated to reelin-producing cells in the spinal cord.

EVX1 EVX2

2.24e-05928215236237
Pubmed

Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13.

KCNC1 KCNC3

3.42e-05112828020965
Pubmed

Commissural axonal corridors instruct neuronal migration in the mouse spinal cord.

EVX1 EVX2

3.42e-051128225960414
Pubmed

A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.

EVX1 EVX2

4.10e-05122821971786
Pubmed

Dbx1 triggers crucial molecular programs required for midline crossing by midbrain commissural axons.

EVX1 EVX2

4.10e-051228224553291
Pubmed

Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1.

EVX1 EVX2

7.45e-051628211239429
Pubmed

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.

EVX1 EVX2

9.49e-051828214723851
Pubmed

Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.

EVX1 EVX2

9.49e-051828212874134
Pubmed

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord.

EVX1 EVX2

9.49e-051828212435628
Pubmed

Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification.

EVX1 EVX2

1.06e-041928211567614
Pubmed

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression.

EVX1 EVX2

2.17e-042728220081190
Pubmed

Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains.

EVX1 EVX2

2.50e-042928230177510
Pubmed

Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.

EVX1 EVX2

3.25e-043328230917309
Pubmed

ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw.

DLX6 TBX2

3.66e-043528228069742
Pubmed

Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3Cre mouse.

EVX1 EVX2

4.78e-044028231152445
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNC1 KCNC3

4.78e-044028216382104
Pubmed

A census of human transcription factors: function, expression and evolution.

EVX1 DLX6 AR EVX2 TBX2

7.16e-0490828519274049
Pubmed

Poor replication of candidate genes for major depressive disorder using genome-wide association data.

PDE10A AR

7.78e-045128220351714
Cytoband17q23.2

EFCAB3 TBX2

2.01e-043329217q23.2
Cytoband7p22.1

RSPH10B2 RSPH10B

4.09e-04472927p22.1
CytobandEnsembl 112 genes in cytogenetic band chr17q23

EFCAB3 TBX2

2.63e-03120292chr17q23
CytobandEnsembl 112 genes in cytogenetic band chr7p22

RSPH10B2 RSPH10B

3.26e-03134292chr7p22
Cytoband7q34

FAM131B TRBV6-9

5.01e-031672927q34
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

TAOK2 TAOK3 MAP3K19

2.69e-0624213654
GeneFamilyPotassium voltage-gated channels

KCNC1 KCNC3

9.76e-0440212274
GeneFamilyHOXL subclass homeoboxes

EVX1 EVX2

1.65e-0352212518
DrugXylazine [7361-61-7]; Up 200; 18.2uM; PC3; HT_HG-U133A

TAOK2 PDE10A AR TBX2

8.00e-051962744066_UP
Drugnaphthol AS-E phosphate

KCNC3 AR

1.41e-0415272ctd:C495860
Drugcarbonyl sulfide

TIA1 AR CYP27A1

3.45e-04116273CID000010039
DrugEmetine

TIA1 AR

6.57e-0432272ctd:D004640
Drugharmaline

KCNC1 KCNC3

7.42e-0434272CID000022381
Drugm262

KCNC1 KCNC3

1.13e-0342272CID000009012
Diseasecentral nervous system disease (implicated_via_orthology)

TAOK2 TAOK3

8.89e-0516262DOID:331 (implicated_via_orthology)
DiseaseAntihypertensive use measurement

PDE10A AR TBX2

1.60e-03265263EFO_0009927
DiseaseAlcoholic Intoxication, Chronic

GGH PDE10A AR

1.65e-03268263C0001973
Diseasediastolic blood pressure, alcohol drinking

EVX1 PDE10A

4.84e-03118262EFO_0004329, EFO_0006336
Diseaseautism spectrum disorder (implicated_via_orthology)

TAOK2 TAOK3

7.90e-03152262DOID:0060041 (implicated_via_orthology)
Diseasemean arterial pressure

TAOK3 PDE10A TBX2

9.36e-03499263EFO_0006340

Protein segments in the cluster

PeptideGeneStartEntry
FMTGPMGFYWRSSPS

BRI3BP

196

Q8WY22
TWPHPADPAFYTYMM

EVX1

246

P49640
SWPHPADPSFYTYMM

EVX2

251

Q03828
VSMPPNSYMPGYSHW

DLX6

146

P56179
MATPGMSWQQHYYGG

FAM184A

1

Q8NB25
MMSGQYWPEGDEVYH

ABHD8

341

Q96I13
WEPWNMNGHVPYMYP

MSANTD5

181

A0A3B3IT52
PMNHGVYTWPDGSMY

RSPH10B

141

P0C881
PMNHGVYTWPDGSMY

RSPH10B2

141

B2RC85
SEMVGYDGPIYMTHP

INTS11

81

Q5TA45
PFENMWPGIFVYMVH

PDE10A

471

Q9Y233
KSEMGPWMDSYSGPY

AR

521

P10275
APMDGWPHSYVSQGM

FAM131B

181

Q86XD5
LGYGDMYPQTWSGML

KCNC1

401

P48547
MEGYKYPVYGVQWHP

GGH

231

Q92820
KYGPMWMSYLGPQMH

CYP27A1

91

Q02318
GYMMSHQFSSLPYPG

KLF18

916

A0A0U1RQI7
HTGPGMLWSPYTMGY

EFCAB3

171

Q8N7B9
SMHGTPYWMAPEVIN

MAP3K19

1226

Q56UN5
QRYWPMYHPSMASTQ

SLC26A8

926

Q96RN1
MAPANSFVGTPYWMA

TAOK2

176

Q9UL54
MASPANSFVGTPYWM

TAOK3

171

Q9H2K8
GHSPYPSVGWMLYDS

SPEM2

296

Q0P670
MYIHPDSPATGEQWM

TBX2

186

Q13207
TPYMYTEWGDSFGSM

ZNF875

271

P10072
SGQYWPSIYHTMASP

WDFY1

56

Q8IWB7
QYMPNGWQVPAYGMY

TIA1

321

P31483
MNHGYLSWYRQDPGM

TRBV6-9

46

A0A0J9YX75
YGDMYPKTWSGMLVG

KCNC3

506

Q14003