Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction5-methylcytosine dioxygenase activity

TET1 TET3

4.98e-053822GO:0070579
GeneOntologyMolecularFunctionU2 snRNA binding

SF3B3 RO60

2.47e-046822GO:0030620
GeneOntologyCellularComponentpresynaptic cytoskeleton

FAM107A PCLO RIMS2

1.98e-0514813GO:0099569
GeneOntologyCellularComponentESCRT-0 complex

STAM2 STAM

4.44e-053812GO:0033565
GeneOntologyCellularComponentcytoskeleton of presynaptic active zone

PCLO RIMS2

4.09e-048812GO:0048788
GeneOntologyCellularComponentGABA-ergic synapse

SLC6A6 MAGI2 PCLO RPS27 RIMS2

4.43e-04164815GO:0098982
Domain-

STAM2 STAM SCAF4

1.70e-04267831.25.40.90
DomainENTH_VHS

STAM2 STAM SCAF4

2.37e-0429783IPR008942
DomainVHS

STAM2 STAM

6.08e-049782PF00790
DomainVHS

STAM2 STAM

6.08e-049782PS50179
DomainVHS

STAM2 STAM

6.08e-049782SM00288
DomainVHS_dom

STAM2 STAM

6.08e-049782IPR002014
Domain-

ZC3H8 ZC3H15 HELZ

6.19e-04407834.10.1000.10
DomainITAM_1

STAM2 STAM

7.58e-0410782PS51055
DomainPhos_immunorcpt_sig_ITAM

STAM2 STAM

7.58e-0410782IPR003110
DomainCENP-B_N

TIGD2 JRKL

7.58e-0410782PF04218
DomainZnF_C3H1

ZC3H8 ZC3H15 HELZ

1.06e-0348783SM00356
DomainCENPB

TIGD2 JRKL

1.11e-0312782SM00674
DomainHTH_Psq

TIGD2 JRKL

1.11e-0312782IPR007889
DomainDDE_1

TIGD2 JRKL

1.11e-0312782PF03184
DomainHTH_PSQ

TIGD2 JRKL

1.11e-0312782PS50960
DomainDDE_SF_endonuclease_dom

TIGD2 JRKL

1.11e-0312782IPR004875
Domainzf-CCCH

ZC3H8 ZC3H15 HELZ

1.12e-0349783PF00642
DomainHTH_CENPB

TIGD2 JRKL

1.30e-0313782PS51253
DomainHTH_Tnp_Tc5

TIGD2 JRKL

1.30e-0313782PF03221
DomainHTH_CenpB_DNA-bd_dom

TIGD2 JRKL

1.30e-0313782IPR006600
DomainZnf_CCCH

ZC3H8 ZC3H15 HELZ

1.83e-0358783IPR000571
DomainZF_C3H1

ZC3H8 ZC3H15 HELZ

1.83e-0358783PS50103
DomainC2

DOC2A CPNE2 PCLO RIMS2

2.21e-03131784PF00168
DomainUIM

STAM2 STAM

2.52e-0318782PF02809
DomainC2

DOC2A CPNE2 PCLO RIMS2

2.60e-03137784SM00239
DomainC2

DOC2A CPNE2 PCLO RIMS2

2.96e-03142784PS50004
DomainSynaptotagmin

DOC2A PCLO

3.12e-0320782IPR001565
Domain-

DOC2A CPNE2 PCLO RIMS2

3.43e-031487842.60.40.150
DomainUIM

STAM2 STAM

3.43e-0321782SM00726
DomainPDZ

MAGI2 PCLO RIMS2 PDLIM5

3.68e-03151784PS50106
DomainPDZ

MAGI2 PCLO RIMS2 PDLIM5

3.77e-03152784IPR001478
DomainNUDIX_BOX

DCP2 TRPM2

4.48e-0324782PS00893
DomainUIM

STAM2 STAM

4.48e-0324782PS50330
DomainUIM_dom

STAM2 STAM

4.85e-0325782IPR003903
DomainC2_dom

DOC2A CPNE2 PCLO RIMS2

4.94e-03164784IPR000008
DomainNUDIX

DCP2 TRPM2

5.24e-0326782PS51462
Domain-

DCP2 TRPM2

6.07e-03287823.90.79.10
DomainNUDIX_hydrolase_dom-like

DCP2 TRPM2

6.07e-0328782IPR015797
DomainNUDIX_hydrolase_dom

DCP2 TRPM2

6.50e-0329782IPR000086
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

STAM2 FAM193A ATAD5 ABCE1 ZC3H15 ANKRD26 SENP6 HELZ RPS27 STAM THOC2 TASOR PDLIM5 SCAF4

3.72e-08934821433916271
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZBTB7A SF3B3 TIGD2 ATAD5 ZC3H8 DNAJA2 RBM42 BEND3 THOC2 TTF1 TASOR TET3 JRKL SCAF4

1.88e-061294821430804502
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZBTB7A SF3B3 TRAFD1 ATAD5 ZNF43 ZC3H15 DNAJA2 CAPRIN2 BEND3 HELZ KAT6B ZNF518A BRWD1

2.05e-061116821331753913
Pubmed

MANF delivery improves retinal homeostasis and cell replacement therapies in ageing mice.

MANF CX3CR1

5.49e-06282232119994
Pubmed

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.

TET1 TET3

5.49e-06282226703470
Pubmed

Hypoxia Drives Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis.

TET1 TET3

5.49e-06282226294212
Pubmed

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage.

MANF CX3CR1

5.49e-06282231489403
Pubmed

Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation.

TET1 TET3

5.49e-06282226711116
Pubmed

Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.

STAM2 STAM

5.49e-06282212446783
Pubmed

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

ATAD5 SENP6 NCKAP5 ZMIZ1 ADAMTSL3 TASOR

7.71e-0619882620881960
Pubmed

Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss.

TET1 TET3

1.64e-05382230074219
Pubmed

Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter.

TET1 TET3

1.64e-05382224194590
Pubmed

TET proteins in malignant hematopoiesis.

TET1 TET3

1.64e-05382219923888
Pubmed

Infrequent occurrence of TET1, TET3, and ASXL2 mutations in myelodysplastic/myeloproliferative neoplasms.

TET1 TET3

1.64e-05382229531217
Pubmed

Hybrid structural model of the complete human ESCRT-0 complex.

STAM2 STAM

1.64e-05382219278655
Pubmed

Selective targeting of TET catalytic domain promotes somatic cell reprogramming.

TET1 TET3

1.64e-05382232024762
Pubmed

Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs.

TET1 TET3

1.64e-05382227184841
Pubmed

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

TET1 TET3

1.64e-05382221778364
Pubmed

Tet family proteins and 5-hydroxymethylcytosine in development and disease.

TET1 TET3

1.64e-05382222569552
Pubmed

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.

TET1 TET3

1.64e-05382219372391
Pubmed

Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK/mTOR pathway.

TRPM2 CX3CR1

1.64e-05382237648036
Pubmed

MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2.

MAGI2 TET1

1.64e-05382232730644
Pubmed

Association with Hrs is required for the early endosomal localization, stability, and function of STAM.

STAM2 STAM

1.64e-05382215113837
Pubmed

Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development.

TET1 TET3

1.64e-05382225608811
Pubmed

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.

TET1 TET3

1.64e-05382219420352
Pubmed

Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.

TET1 TET3

1.64e-05382228218476
Pubmed

Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.

TET1 TET3

1.64e-05382223548903
Pubmed

5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function.

TET1 TET3

1.64e-05382234919053
Pubmed

Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.

STAM2 STAM

1.64e-05382213679051
Pubmed

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.

TET1 TET3

1.64e-05382224958354
Pubmed

Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer.

TET1 TET3

1.64e-05382226207381
Pubmed

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.

TET1 TET3

1.64e-05382223643243
Pubmed

Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.

TET1 TET3

1.64e-05382234879277
Pubmed

Oxygen regulation of TET enzymes.

TET1 TET3

1.64e-05382233410283
Pubmed

Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.

TET1 TET3

1.64e-05382222445327
Pubmed

Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.

TET1 TET3

1.64e-05382224735881
Pubmed

Differential expression of ten-eleven translocation genes in endometrial cancers.

TET1 TET3

1.64e-05382228349832
Pubmed

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.

TET1 TET3

1.64e-05382220639862
Pubmed

Ten-Eleven Translocation Genes are Downregulated in Endometriosis.

TET1 TET3

1.64e-05382226917261
Pubmed

Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility.

TET1 TET3

1.64e-05382230130982
Pubmed

Regulation of DNA methylation signatures on NF-κB and STAT3 pathway genes and TET activity in cigarette smoke extract-challenged cells/COPD exacerbation model in vitro.

TET1 TET3

1.64e-05382232342329
Pubmed

The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.

STAM2 STAM

3.28e-05482226601948
Pubmed

Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.

TET1 TET3

3.28e-05482235235365
Pubmed

STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif.

STAM2 STAM

3.28e-05482212972556
Pubmed

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.

TET1 TET3

3.28e-05482221321204
Pubmed

Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.

TET1 TET3

3.28e-05482231371502
Pubmed

HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly.

ABCE1 DCP2

3.28e-05482222851315
Pubmed

Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).

TET1 TET3

3.28e-05482224394411
Pubmed

Immune modulation by MANF promotes tissue repair and regenerative success in the retina.

MANF CX3CR1

3.28e-05482227365452
Pubmed

Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.

TET1 TET3

3.28e-05482223028748
Pubmed

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.

TET1 TET3

3.28e-05482230554962
Pubmed

TET1 Directs Chondrogenic Differentiation by Regulating SOX9 Dependent Activation of Col2a1 and Acan In Vitro.

TET1 TET3

3.28e-05482233134768
Pubmed

Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).

TET1 TET3

3.28e-05482225568311
Pubmed

A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors.

TET1 TET3

3.28e-05482225089631
Pubmed

STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.

STAM2 STAM

3.28e-05482212551915
Pubmed

STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking.

STAM2 STAM

3.28e-05482219054391
Pubmed

The intrinsic and extrinsic effects of TET proteins during gastrulation.

TET1 TET3

3.28e-05482235908548
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SF3B3 PSME4 TET1 CAPRIN2 SENP6 KAT6B RIMS2 FRMD4B

3.61e-0552982814621295
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

RANBP17 ZBTB7A TMEM120B MAOA ZC3H8 TRPM2 AFF3 STYXL1 ZMIZ1 PPM1K KAT6B TTF1 TET3

4.38e-051489821328611215
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

NRDE2 SF3B3 FAM193A ATAD5 ZC3H15 DNAJA2 ANKRD26 HELZ PDLIM5

5.29e-0572482936232890
Pubmed

DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.

TET1 TET3

5.47e-05582236880575
Pubmed

Structure and ubiquitin binding of the ubiquitin-interacting motif.

STAM2 STAM

5.47e-05582212750381
Pubmed

Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.

STAM2 STAM

5.47e-05582217235283
Pubmed

Dynamic expression of TET1, TET2, and TET3 dioxygenases in mouse and human placentas throughout gestation.

TET1 TET3

5.47e-05582229108636
Pubmed

Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis.

PCLO RIMS2

5.47e-05582212401793
Pubmed

Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.

STAM2 STAM

5.47e-05582222275353
Pubmed

Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex.

STAM2 STAM

5.47e-05582220736164
Pubmed

Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.

STAM2 STAM

5.47e-05582211687594
Pubmed

CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.

TET1 TET3

5.47e-05582235304452
Pubmed

Lineage-specific functions of TET1 in the postimplantation mouse embryo.

TET1 TET3

5.47e-05582228504700
Pubmed

PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.

STAM2 STAM

5.47e-05582220504764
Pubmed

Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.

TET1 TET3

5.47e-05582235737830
Pubmed

CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.

TET1 TET3

5.47e-05582225557551
Pubmed

TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis.

TET1 TET3

5.47e-05582228923852
Pubmed

Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a.

TET1 TET3

5.47e-05582223820384
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

PPP1R3C TET1 ZMIZ1 STAM KAT6B IFIT2 CHUK

5.77e-0541582716385451
Pubmed

Piccolo, a presynaptic zinc finger protein structurally related to bassoon.

PCLO RIMS2

8.19e-05682210707984
Pubmed

Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development.

TET1 TET3

8.19e-05682239262804
Pubmed

TET1 contributes to neurogenesis onset time during fetal brain development in mice.

TET1 TET3

8.19e-05682226902115
Pubmed

DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons.

TET1 TET3

8.19e-05682232147726
Pubmed

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.

STAM2 STAM

8.19e-05682210982817
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SF3B3 ATAD5 ZC3H15 MANF SENP6 BEND3 RPS27 THOC2 TASOR SCAF4

8.26e-05954821036373674
Pubmed

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.

SLC6A6 FAM228B SF3B3 TRAFD1 ZC3H8 ZC3H15 DNAJA2 RBM42 RO60 RPS27

9.55e-05971821033306668
Pubmed

Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development.

TET1 TET3

1.14e-04782230185805
Pubmed

Osteoclasts adapt to physioxia perturbation through DNA demethylation.

TET3 CX3CR1

1.14e-04782234661337
Pubmed

Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy.

CX3CR1 CHUK

1.14e-04782233523920
Pubmed

AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.

STAM2 STAM

1.14e-04782220159979
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

FAM193A IRAK4 HELZ STAM PDLIM5 CHUK

1.17e-0432282639098523
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

CAPRIN2 SENP6 RPS27 THOC2 HELQ

1.37e-0420882533230847
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

DOC2A SF3B3 FAM161A PCLO CAPRIN2 MANF RBM42 ANKRD26 BEND3 RIMS2 TASOR CHUK

1.39e-041442821235575683
Pubmed

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.

TET1 TET3

1.52e-04882226199412
Pubmed

Downregulation of ten-eleven translocation-2 triggers epithelial differentiation during organogenesis.

TET1 TET3

1.52e-04882235569195
Pubmed

STAM2, a new member of the STAM family, binding to the Janus kinases.

STAM2 STAM

1.52e-04882210899310
Pubmed

DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.

TET1 TET3

1.52e-04882228614801
Pubmed

Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice.

MAOA TET1 TET3

1.90e-044782332892421
Pubmed

TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons.

TET1 TET3

1.96e-04982231361780
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NRDE2 PSME4 FAM107A ABCE1 TET1 ZNF254 IRAK4 THOC2 TASOR BRWD1

2.33e-041084821011544199
Pubmed

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

TET1 TET3

2.44e-041082229276034
Pubmed

DYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release.

MAGI2 DNAJA2

2.44e-041082236585413
Pubmed

Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies.

TET1 TET3

2.44e-041082231467060
CytobandEnsembl 112 genes in cytogenetic band chr4q22

TIGD2 PPM1K PDLIM5

3.25e-0474823chr4q22
Cytoband4q22.1

TIGD2 PPM1K

9.96e-04268224q22.1
Cytoband21q22.2

LCA5L BRWD1

1.61e-033382221q22.2
CytobandEnsembl 112 genes in cytogenetic band chr3p14

FAM107A TASOR FRMD4B

2.06e-03140823chr3p14
Cytoband3p21.1

FAM107A MANF

2.59e-03428223p21.1
GeneFamilyESCRT-0

STAM2 STAM

3.03e-0535821115
GeneFamilyZinc fingers CCCH-type

ZC3H8 ZC3H15 HELZ

1.91e-043558373
GeneFamilyZinc fingers CXXC-type

TET1 TET3

6.54e-0412582136
GeneFamilyHelix-turn-helix CENPB type domain containing

TIGD2 JRKL

7.71e-0413582533
GeneFamilyPDZ domain containing

MAGI2 PCLO RIMS2 PDLIM5

1.43e-031525841220
GeneFamilyNudix hydrolase family

DCP2 TRPM2

2.67e-0324582667
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_1000

PPP1R3C SLC6A6 ZNF43 TET1 AFF3 RO60 STAM FRMD4B

9.85e-06281798gudmap_developingGonad_e18.5_epididymis_1000_k3
CoexpressionAtlasDevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000

SLC6A6 ZNF43 TET1 ANKRD26 RO60 CHORDC1 THOC2 FRMD4B

2.68e-05323798gudmap_developingGonad_e11.5_ovary + mesonephros_k2_1000
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000

PPP1R3C SLC6A6 MAOA ZNF43 TET1 AFF3 RO60 ZMIZ1 PPM1K THOC2 FRMD4B CX3CR1

3.36e-057907912gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000

RANBP17 SF3B3 SWT1 ZC3H8 TET1 CAPRIN2 ANKRD26 HELZ RIMS2 ZNF518A CHUK BRWD1

4.82e-058207912gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NRDE2 SWT1 GUCY2C ZC3H8 RPS27 TASOR

1.49e-06192826fcdb2e924800457d21e4aaeeedd81dbf80216eed
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

NRDE2 CAPRIN2 ANKRD26 THOC2 RIMS2 TTF1

1.73e-061978260fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell356C-Lymphocytic-ILC-ILC-3|ILC / Donor, Lineage, Cell class and subclass (all cells)

FAM228B ZNF570 KAT6B CX3CR1

4.94e-0661824d0b33a48ee2faf68b270f9279c630437f3e8b20b
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DDX59 SWT1 ABCE1 AFF3 STAM

1.57e-05170825070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCellSevere-CD4+_T_activated|Severe / Disease group and Cell class

TRAFD1 PPM1K CHORDC1 IFIT2 FRMD4B

1.90e-05177825a08f170f1143fcdd7d0842a54d9b807a4548f8b7
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATAD5 TET1 SENP6 RPS27 TASOR

2.17e-05182825e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATAD5 TET1 SENP6 RPS27 TASOR

2.17e-051828251710eab3037a87609d21838be2d2d29c3bc36651
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_3|390C / Donor, Lineage, Cell class and subclass (all cells)

CPNE2 DCP2 IRAK4 LINGO2 FRMD4B

2.23e-05183825228092290dbb08785c4eda224e3ad03e99e10fab
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SLC6A6 FAM193A SENP6 STAM SCAF4

2.41e-0518682576cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB7A PSME4 SENP6 TASOR ZNF518A

2.74e-0519182560c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB7A PSME4 SENP6 TASOR ZNF518A

2.74e-0519182509db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB7A PSME4 SENP6 TASOR ZNF518A

2.74e-05191825973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

MAOA FAM107A RHOJ PPP1R17 PDLIM5

2.95e-051948257c6c0376603e5fcb64814fd6204d153629c2fbf5
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PPP1R3C MAGI2 MAOA AFF3 RPS27

2.95e-05194825a3e5a15cf6c1361207f661ee15eb634f77daf1cb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO AFF3 LINGO2 RIMS2 SRRM3

3.10e-05196825676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellIPF-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

SLC6A6 MAOA FAM107A AFF3 NCKAP5

3.10e-051968258f0f72ead06abe02b575e443552eacc2151077ef
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TRPM2 AFF3 NCKAP5 FRMD4B CX3CR1

3.10e-05196825e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCellCV-Moderate-1|CV / Virus stimulation, Condition and Cluster

TRAFD1 LPIN2 PPM1K IFIT2 CX3CR1

3.18e-05197825e3d00d850b4d191f9592ef993c0eaadfe5710b5f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCLO AFF3 LINGO2 RIMS2 SRRM3

3.25e-051988250ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-Treg|Leuk-UTI / Disease, condition lineage and cell class

CPNE2 FAM161A MTRFR RPS27 STAM

3.33e-05199825100f45e04f284551b29ef0406476bdc347ddbf7e
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

PCLO AFF3 LINGO2 RIMS2 SRRM3

3.41e-0520082548d801219bc771d6c7e151dc88ca4c179988de85
DrugSuccimer

CPNE2 MAGI2 ZBTB7A MAOA ATAD5 ABCE1 ZC3H15 ANKRD26 HELZ RO60 THOC2 RIMS2 FRMD4B PDLIM5 CX3CR1 ZNF518A CHUK BRWD1

4.39e-0712648218ctd:D004113
DrugMagnetite Nanoparticles

CPNE2 MAGI2 ZBTB7A ATAD5 ABCE1 ZC3H15 ANKRD26 HELZ RO60 THOC2 RIMS2 FRMD4B PDLIM5 CX3CR1 ZNF518A CHUK BRWD1

3.44e-0613108217ctd:D058185
Drug5-Methylcytosine

TET1 TET3

3.84e-053822ctd:D044503
DrugThioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A

TRAFD1 PSME4 ANKRD26 SENP6 TASOR PDLIM5

6.46e-051908262619_DN
DrugSanguinarine [2447-54-3]; Down 200; 12uM; MCF7; HT_HG-U133A

SF3B3 ATAD5 PCLO LPIN2 RO60 BRWD1

6.65e-051918264168_DN
DrugNafronyl oxalate [3200-06-4]; Down 200; 8.4uM; HL60; HT_HG-U133A

ZBTB7A STAM2 RBM42 KAT6B SCAF4 BRWD1

7.45e-051958261267_DN
DrugMetrizamide [31112-62-6]; Down 200; 5uM; MCF7; HT_HG-U133A

SLC6A6 TRAFD1 TRPM2 RO60 RIMS2 SCAF4

7.45e-051958264156_DN
DrugRiluzole hydrochloride; Down 200; 14.8uM; MCF7; HT_HG-U133A

DOC2A PPP1R3C MAOA ATAD5 PDLIM5 SCAF4

7.67e-051968264689_DN
DrugCondelphine [7633-69-4]; Down 200; 8.8uM; HL60; HT_HG-U133A

STAM2 ATAD5 CAPRIN2 SENP6 STAM IFIT2

7.67e-051968262976_DN
DrugScoulerine [6451-73-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

SLC6A6 STAM2 ATAD5 PCLO LPIN2 SENP6

7.67e-051968265111_DN
DrugCyanocobalamin [68-19-9]; Down 200; 3uM; HL60; HT_HG-U133A

TRAFD1 PSME4 LPIN2 SENP6 SCAF4 BRWD1

7.67e-051968261315_DN
DrugDioxybenzone [131-53-3]; Down 200; 16.4uM; HL60; HT_HG-U133A

STAM2 MTMR12 PCLO RBM42 SENP6 IFIT2

7.67e-051968263101_DN
DrugPyrimethamine [58-14-0]; Down 200; 16uM; MCF7; HT_HG-U133A

DOC2A SLC6A6 ZBTB7A ATAD5 CAPRIN2 SENP6

7.67e-051968261474_DN
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; HL60; HT_HG-U133A

STAM2 ZNF43 ZNF254 RBM42 KAT6B BRWD1

7.67e-051968261326_UP
Drugaspirin, USP; Up 200; 100uM; MCF7; HT_HG-U133A

ATAD5 LPIN2 ANKRD26 KAT6B RIMS2 SCAF4

7.89e-051978261629_UP
DrugCP-319743 [172078-87-4]; Down 200; 10uM; MCF7; HT_HG-U133A

NRDE2 ZBTB7A STAM2 ATAD5 JRKL PDLIM5

7.89e-051978267486_DN
DrugAzaperone [1649-18-9]; Down 200; 12.2uM; HL60; HT_HG-U133A

MTMR12 TMEM120B TRAFD1 MAOA ANKRD26 RO60

7.89e-051978266151_DN
Drug(+,-)-Synephrine [94-07-5]; Down 200; 24uM; PC3; HT_HG-U133A

RANBP17 STAM2 DCP2 ANKRD26 SCAF4 BRWD1

7.89e-051978267150_DN
DrugCortisone [53-06-5]; Down 200; 11uM; MCF7; HT_HG-U133A

PPP1R3C STAM2 ZNF254 LPIN2 SENP6 KAT6B

8.11e-051988267416_DN
DrugTadjakonine [11087-94-8]; Down 200; 7.4uM; HL60; HT_HG-U133A

DOC2A PPP1R3C RANBP17 TRAFD1 RO60 PDLIM5

8.34e-051998262165_DN
DrugSC 19220; Down 200; 10uM; MCF7; HT_HG-U133A

PPP1R3C SLC6A6 LPIN2 ANKRD26 RO60 PDLIM5

8.34e-051998267090_DN
Drugchlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A_EA

ZBTB7A STAM2 PSME4 ATAD5 ZNF43 PDLIM5

8.34e-051998261055_DN
DrugTetracaone hydrochloride [136-47-0]; Up 200; 13.2uM; HL60; HG-U133A

STAM2 MAOA CAPRIN2 RIMS2 IFIT2 SCAF4

8.34e-051998261739_UP
DrugMoxisylyte hydrochoride [964-52-3]; Up 200; 12.6uM; PC3; HT_HG-U133A

STAM2 ZNF254 LPIN2 IFIT2 SCAF4 BRWD1

8.34e-051998261804_UP
DrugFinasteride [98319-26-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A

SLC6A6 TRPM2 RIMS2 ADAMTSL3 FRMD4B PDLIM5

8.34e-051998263641_DN
DrugDiphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A

TMEM120B ATAD5 PCLO RIMS2 PDLIM5 BRWD1

8.34e-051998264765_DN
DrugAcenocoumarol [152-72-7]; Up 200; 11.4uM; PC3; HT_HG-U133A

ZBTB7A STAM2 TMEM120B TRAFD1 LPIN2 IRAK4

8.57e-052008262077_UP
DiseaseGrowth abnormality

ZMIZ1 TET3

2.23e-053812C0262361
DiseaseCCL24 measurement

MAGI2 STYXL1 SRRM3

2.96e-0522813EFO_0009418
DiseaseNADPH--cytochrome P450 reductase measurement

STYXL1 SRRM3

4.45e-054812EFO_0008242
Diseaserevision of total knee arthroplasty

SLC6A6 MAGI2 LINGO2

4.95e-0526813EFO_0020972
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

RANBP17 MAGI2 AFF3 HELZ LINGO2 TET3 ZNF518A SCAF4 BRWD1

3.49e-04801819EFO_0003888, EFO_0007052, MONDO_0002491
Diseasemammographic density measurement

AFF3 ADAMTSL3 TET3

3.56e-0450813EFO_0005941
Diseasemean platelet volume

MSANTD1 SLC6A6 TMEM120B ATAD5 AFF3 STYXL1 ZMIZ1 SRRM3 TASOR PDLIM5

4.74e-0410208110EFO_0004584
Diseaseheat shock protein beta-1 measurement

STYXL1 SRRM3

4.83e-0412812EFO_0010595
Diseasepolycystic kidney disease (implicated_via_orthology)

STAM2 STAM

6.63e-0414812DOID:0080322 (implicated_via_orthology)
Diseaseanthropometric measurement

ATAD5 ZMIZ1 ADAMTSL3 PDLIM5

1.20e-03168814EFO_0004302
Diseaseage at menarche

MSANTD1 MAGI2 AFF3 SENP6 HELQ ZNF518A BRWD1

1.24e-03594817EFO_0004703
Diseaseairway responsiveness measurement

CAPRIN2 LINGO2

1.98e-0324812EFO_0006897
Diseasealcohol consumption measurement

MSANTD1 RANBP17 MAGI2 PCLO AFF3 SENP6 NCKAP5 LINGO2 RIMS2 TET3

2.10e-0312428110EFO_0007878
Diseasevisceral adipose tissue measurement

RANBP17 MAGI2 ZBTB7A HELZ LINGO2 PDLIM5

2.11e-03481816EFO_0004765
Diseasebody fat percentage

RANBP17 MAGI2 TET1 TRPM2 LINGO2 ADAMTSL3

2.26e-03488816EFO_0007800
DiseasePR interval

MAGI2 LPIN2 NCKAP5 ZMIZ1 FRMD4B PDLIM5

2.43e-03495816EFO_0004462
DiseasePsychotic Disorders

MAOA TET1 TRPM2

2.74e-03101813C0033975

Protein segments in the cluster

PeptideGeneStartEntry
DKKKKKCSIHKERPQ

TTF1

16

Q15361
EKALPKSKRKRKCDN

AFF3

811

P51826
RLCKKSKPIKKQQDV

ADAM29

696

Q9UKF5
VKDCEIEPCKKRKKD

ATAD5

16

Q96QE3
PKNTKKKRVDLPKCD

ATAD5

1441

Q96QE3
KIIEKVCSHKKIKKR

FAM228B

91

P0C875
LEFECINPKKQRKKK

CPNE2

261

Q96FN4
CKNHKKAKAIKLILL

CX3CR1

221

P49238
NSLMKCEKKLHPRKL

DCP2

346

Q8IU60
LKKNHCELLTVKIKK

ANKRD26

741

Q9UPS8
RAVKKKKKERPSKDC

FAM193A

931

P78312
KHIAKEGKKPLRCRE

RANBP17

946

Q9H2T7
EDKKKGKPEKLKRCI

RBM42

346

Q9BTD8
HTPERKDEKERIKKC

PPM1K

226

Q8N3J5
KKKKEELEAKRLQCP

FAM107A

81

O95990
CKYDKKRVILKDLKH

GUCY2C

506

P25092
VCRPKKKGRKLLHEK

KAT6B

316

Q8WYB5
RPNRKKCDILKKAKK

BEND3

811

Q5T5X7
LAKLHKEIRKKKICE

MAOA

361

P21397
KKRKVQSCHLQKKQL

MSANTD1

206

Q6ZTZ1
IKHCKDPLRLKCVKQ

MAGI2

86

Q86UL8
QLKKYPEKLIIHCKD

MTMR12

131

Q9C0I1
HEKIKKKDPKCIFAC

CHUK

231

O15111
CKAKHLLQVKEKEEK

DDX59

131

Q5T1V6
QKKVIKKKTRVCRHD

PCLO

5061

Q9Y6V0
KNCKKLAKNLLKEPE

NRDE2

761

Q9H7Z3
HCVNKLPKQEDSKRK

LCA5L

411

O95447
TCKKPKIREKKLQHL

LINGO2

406

Q7L985
HKLKLCVVGKAKKPR

JRKL

221

Q9Y4A0
KKDKPLCKKHAHSVN

PDLIM5

581

Q96HC4
KIVLKEKHKKACVHG

CHRDL2

241

Q6WN34
TCKHKQTPIKKKEQL

HELZ

1001

P42694
ILTIFHPKKKKKRCS

RHOJ

191

Q9H4E5
PVEKICEKLKKKDSQ

MANF

101

P55145
RQKKKVKEEHKPQLT

RIMS2

46

Q9UQ26
RCKKCEGKKVIKEVK

DNAJA2

201

O60884
ANEPDLCKTVKKKRK

FRMD4B

521

Q9Y2L6
TRIAIVNHDKCKPKK

ABCE1

6

P61221
RPDVDKKSKHKTCVK

DOC2A

296

Q14183
AKIRKLKEIKPVVHC

DCDC2C

106

A8MYV0
RKKPLHLACTTAKKK

BRWD1

1961

Q9NSI6
LICLKHKIRNIEKKK

CAPRIN2

126

Q6IMN6
RAKVCFEKALEKKPK

IFIT2

156

P09913
CLHEKKNKRPDIKKV

IRAK4

436

Q9NWZ3
LKHKEKEKCEVIKNL

HELQ

606

Q8TDG4
CPEQAVKLKCKHKVR

FAM161A

411

Q3B820
KHVVQIVEKFIKKCK

SCAF4

41

O95104
KPKKCVKCLQKTVKD

C9orf85

66

Q96MD7
CKRKEKNKEKKRPHT

SRRM3

231

A6NNA2
KLQCLKDFHKDILKP

SLC6A6

6

P31641
KPLKSCLNIKHKAKS

PPP1R3C

56

Q9UQK1
CNKKLEKRLLKKHEE

TRAFD1

66

O14545
KKHLKDLKLTLQRCK

TMEM120B

51

A0PK00
RKKEKKKPELQCETE

NCKAP5

1551

O14513
KKDIHKCVDFKPKDI

SWT1

121

Q5T5J6
EKLCNEKLLKKARIH

RO60

306

P10155
KVHCKFQKKLKELGR

TASOR

1366

Q9UK61
KKVPLSKGLEKQHDC

TET1

126

Q8NFU7
HQICKKRKCEELKKK

TET1

616

Q8NFU7
KRKCEELKKKPSVVV

TET1

621

Q8NFU7
EKKELCELKPKFQEH

CHORDC1

81

Q9UHD1
VKRCKNPSINEKLHK

CNK3/IPCEF1

806

G9CGD6
KDCDLKKKPRKGKNV

PPP1R17

36

O96001
HKLNLCVVGKAKKPR

TIGD2

221

Q4W5G0
PNKKKKEKERCTALQ

THOC2

921

Q8NI27
PVHKEKREAAKKKQE

MTRFR

126

Q9H3J6
ACDPKIQKDLKIKAH

STYXL1

176

Q9Y6J8
TPAKRHKQLKNKLEK

TRPM2

1101

O94759
KPVIKKMLNKKHCIA

SENP6

821

Q9GZR1
VLNKGHPKVCEKLKA

STAM

96

Q92783
VIKNKAHPKVCEKLK

STAM2

96

O75886
RKATLHRKCKEKAKP

ZNF518A

1291

Q6AHZ1
HQICKLRKCEVLKKK

TET3

81

O43151
IHFEQLCKTKLPKKR

PSME4

1726

Q14997
DLGKKKLLRKCENKH

SF3B3

971

Q15393
KKIHIEKKPYKCEEC

ZNF43

501

P17038
IKPKSVCAEKKLLKC

ZNF570

206

Q96NI8
KKKPKTQIVCKHFLE

ZC3H15

171

Q8WU90
SPEEEKRKHKKKRLV

RPS27

11

P42677
RPKIRHTEKKSFKCK

ZNF254

171

O75437
KVEKKIRAKAFQKCP

ZBTB7A

371

O95365
GNEEKERLKKCPKQK

ZNF785

116

A8K8V0
ERLKKCPKQKEVAHE

ZNF785

121

A8K8V0
KKRLLPAEHCITKIK

ZMIZ1

696

Q9ULJ6
KIKLECEQIPKKFRH

ZC3H8

41

Q8N5P1
KPVAKRHCVQKKKPI

ADAMTSL3

1631

P82987
KKPEKFKIECLNDIK

LPIN2

781

Q92539