Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alkaline phosphatase activity	CILP2 CILP	1.91e-04	6	72	2	GO:0004035
GeneOntologyMolecularFunction	C3HC4-type RING finger domain binding	KCNH2 PINK1	1.91e-04	6	72	2	GO:0055131
GeneOntologyMolecularFunction	dinucleotide phosphatase activity	CILP2 CILP	4.54e-04	9	72	2	GO:0004551
GeneOntologyBiologicalProcess	negative regulation of potassium ion transport	KCNH2 GNAQ AGRN NOS3	1.99e-05	46	72	4	GO:0043267
GeneOntologyBiologicalProcess	regulation of hydrogen peroxide metabolic process	ZNF205 STAT3 PINK1	6.87e-05	23	72	3	GO:0010310
GeneOntologyBiologicalProcess	hydrogen peroxide metabolic process	LPO ZNF205 STAT3 PINK1	8.86e-05	67	72	4	GO:0042743
GeneOntologyBiologicalProcess	positive regulation of purine nucleotide biosynthetic process	NOS3 STAT3 PINK1	8.88e-05	25	72	3	GO:1900373
GeneOntologyBiologicalProcess	positive regulation of nucleotide biosynthetic process	NOS3 STAT3 PINK1	8.88e-05	25	72	3	GO:0030810
Domain	TIL	FCGBP ZAN SSPOP OTOG	9.82e-08	12	72	4	PF01826
Domain	C8	FCGBP ZAN SSPOP OTOG	9.82e-08	12	72	4	PF08742
Domain	Unchr_dom_Cys-rich	FCGBP ZAN SSPOP OTOG	1.41e-07	13	72	4	IPR014853
Domain	C8	FCGBP ZAN SSPOP OTOG	1.41e-07	13	72	4	SM00832
Domain	TIL_dom	FCGBP ZAN SSPOP OTOG	1.97e-07	14	72	4	IPR002919
Domain	VWD	FCGBP ZAN SSPOP OTOG	3.57e-07	16	72	4	SM00216
Domain	VWF_type-D	FCGBP ZAN SSPOP OTOG	3.57e-07	16	72	4	IPR001846
Domain	VWFD	FCGBP ZAN SSPOP OTOG	3.57e-07	16	72	4	PS51233
Domain	VWD	FCGBP ZAN SSPOP OTOG	3.57e-07	16	72	4	PF00094
Domain	VWC_out	FCGBP ZAN SSPOP OTOG	7.53e-07	19	72	4	SM00215
Domain	VWF_dom	FCGBP ZAN SSPOP OTOG	2.03e-05	42	72	4	IPR001007
Domain	EGF_3	ZAN CUBN VWA2 SSPOP AGRN LDLR OTOG	3.36e-05	235	72	7	PS50026
Domain	TILa	FCGBP ZAN	4.39e-05	3	72	2	PF12714
Domain	TILa_dom	FCGBP ZAN	4.39e-05	3	72	2	IPR025615
Domain	EGF-like_dom	FCGBP ZAN CUBN VWA2 AGRN LDLR OTOG	4.85e-05	249	72	7	IPR000742
Domain	LRRC37AB_C	LRRC37A LRRC37A2	8.75e-05	4	72	2	PF14914
Domain	Gprotein_alpha_Q	GNA14 GNAQ	8.75e-05	4	72	2	IPR000654
Domain	LRRC37_N	LRRC37A LRRC37A2	8.75e-05	4	72	2	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A2	8.75e-05	4	72	2	IPR029423
Domain	LRRC37	LRRC37A LRRC37A2	8.75e-05	4	72	2	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A2	8.75e-05	4	72	2	IPR015753
Domain	TSP_1	CILP2 CILP ADAMTS8 SSPOP	1.02e-04	63	72	4	PF00090
Domain	TSP1	CILP2 CILP ADAMTS8 SSPOP	1.15e-04	65	72	4	SM00209
Domain	TSP1_rpt	CILP2 CILP ADAMTS8 SSPOP	1.15e-04	65	72	4	IPR000884
Domain	TSP1	CILP2 CILP ADAMTS8 SSPOP	1.15e-04	65	72	4	PS50092
Domain	WxxW_domain	CILP2 CILP	2.18e-04	6	72	2	IPR025155
Domain	Mucin2_WxxW	CILP2 CILP	2.18e-04	6	72	2	PF13330
Domain	EGF	FCGBP ZAN CUBN VWA2 AGRN LDLR	2.91e-04	235	72	6	SM00181
Domain	STAT_TF_prot_interaction	STAT3 STAT4	3.04e-04	7	72	2	IPR013799
Domain	STAT_TF_DNA-bd_sub	STAT3 STAT4	3.04e-04	7	72	2	IPR012345
Domain	STAT	STAT3 STAT4	3.04e-04	7	72	2	IPR001217
Domain	STAT_TF_coiled-coil	STAT3 STAT4	3.04e-04	7	72	2	IPR015988
Domain	-	STAT3 STAT4	3.04e-04	7	72	2	2.60.40.630
Domain	STAT_int	STAT3 STAT4	3.04e-04	7	72	2	SM00964
Domain	STAT_TF_DNA-bd	STAT3 STAT4	3.04e-04	7	72	2	IPR013801
Domain	STAT_bind	STAT3 STAT4	3.04e-04	7	72	2	PF02864
Domain	STAT_int	STAT3 STAT4	3.04e-04	7	72	2	PF02865
Domain	-	STAT3 STAT4	3.04e-04	7	72	2	1.10.532.10
Domain	STAT_alpha	STAT3 STAT4	3.04e-04	7	72	2	PF01017
Domain	-	STAT3 STAT4	3.04e-04	7	72	2	1.20.1050.20
Domain	STAT_TF_alpha	STAT3 STAT4	4.04e-04	8	72	2	IPR013800
Domain	VWC	FCGBP ZAN SSPOP	4.21e-04	38	72	3	SM00214
Domain	EGF_1	ZAN CUBN VWA2 SSPOP AGRN LDLR	4.49e-04	255	72	6	PS00022
Domain	EGF_2	ZAN CUBN VWA2 SSPOP AGRN LDLR	5.50e-04	265	72	6	PS01186
Domain	Fol_N	FCGBP AGRN	7.88e-04	11	72	2	IPR003645
Domain	FOLN	FCGBP AGRN	7.88e-04	11	72	2	SM00274
Domain	EGF_CA	CUBN VWA2 AGRN LDLR	1.27e-03	122	72	4	SM00179
Domain	EGF-like_Ca-bd_dom	CUBN VWA2 AGRN LDLR	1.34e-03	124	72	4	IPR001881
Domain	EGF	ZAN CUBN VWA2 AGRN	1.43e-03	126	72	4	PF00008
Domain	G-alpha	GNA14 GNAQ	1.70e-03	16	72	2	PF00503
Domain	GproteinA_insert	GNA14 GNAQ	1.70e-03	16	72	2	IPR011025
Domain	-	GNA14 GNAQ	1.70e-03	16	72	2	1.10.400.10
Domain	G_alpha	GNA14 GNAQ	1.70e-03	16	72	2	SM00275
Domain	CarboxyPept-like_regulatory	CILP2 CILP	1.92e-03	17	72	2	IPR008969
Domain	Gprotein_alpha_su	GNA14 GNAQ	1.92e-03	17	72	2	IPR001019
Domain	EGF-like_CS	ZAN CUBN VWA2 AGRN LDLR	3.35e-03	261	72	5	IPR013032
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1 OTOG	1.51e-06	11	74	3	31776257
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	VPS11 SMCHD1 NLRX1 LSS GNAQ CCDC9 LDLR TARBP2 TBL2 ABHD16A PLXNA1 NUBP2	2.35e-06	1061	74	12	33845483
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CRYBG2 EFNA2 MROH6 KCNH2 PPP1R15B NLRX1 SBF2 BCR AGRN LDLR RNF43 PLXNA1	3.56e-06	1105	74	12	35748872
Pubmed	Intronic microRNA suppresses endothelial nitric oxide synthase expression and endothelial cell proliferation via inhibition of STAT3 signaling.	NOS3 STAT3	4.47e-06	2	74	2	21611796
Pubmed	eNOS phosphorylation and translocation are altered in male but not female mice by increased activation of the Gαq protein.	GNAQ NOS3	4.47e-06	2	74	2	20237586
Pubmed	STAT4 Regulates the CD8+ Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr-/- Mice.	LDLR STAT4	4.47e-06	2	74	2	29055004
Pubmed	Recurrent GNA14 mutations in anastomosing haemangiomas.	GNA14 GNAQ	4.47e-06	2	74	2	29574926
Pubmed	STAT3 but not STAT4 is critical for γδT17 cell responses and skin inflammation.	STAT3 STAT4	4.47e-06	2	74	2	31549795
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	4.47e-06	2	74	2	34910522
Pubmed	Stat3 and Stat4 direct development of IL-17-secreting Th cells.	STAT3 STAT4	4.47e-06	2	74	2	17404271
Pubmed	Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.	CILP2 CILP	4.47e-06	2	74	2	21880736
Pubmed	Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr-/- mice.	LDLR STAT4	4.47e-06	2	74	2	37396582
Pubmed	Association of STAT3 and STAT4 polymorphisms with susceptibility to chronic hepatitis B virus infection and risk of hepatocellular carcinoma: a meta-analysis.	STAT3 STAT4	4.47e-06	2	74	2	31160486
Pubmed	Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm.	GNA14 GNAQ	4.47e-06	2	74	2	29975248
Pubmed	Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model.	NOS3 STAT3	4.47e-06	2	74	2	29581793
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	4.47e-06	2	74	2	11687802
Pubmed	Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations.	STAT3 STAT4	4.47e-06	2	74	2	22753649
Pubmed	Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.	BCR STAT3	4.47e-06	2	74	2	12821944
Pubmed	Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease.	STAT3 STAT4	4.47e-06	2	74	2	12615922
Pubmed	GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas.	GNA14 GNAQ	4.47e-06	2	74	2	38917801
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1 OTOG	6.15e-06	17	74	3	20856818
Pubmed	A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.	CILP2 LDLR TBL2	8.74e-06	19	74	3	19656773
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	1.34e-05	3	74	2	30801007
Pubmed	Arginine 313 of the putative 8th helix mediates Gαq/14 coupling of human CC chemokine receptors CCR2a and CCR2b.	GNA14 GNAQ	1.34e-05	3	74	2	30321592
Pubmed	Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation.	LDLR NOS3	1.34e-05	3	74	2	31154825
Pubmed	Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.	BCR STAT3	1.34e-05	3	74	2	25134459
Pubmed	High frequency of GNA14, GNAQ, and GNA11 mutations in cherry hemangioma: a histopathological and molecular study of 85 cases indicating GNA14 as the most commonly mutated gene in vascular neoplasms.	GNA14 GNAQ	1.34e-05	3	74	2	31189994
Pubmed	Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene.	STAT3 STAT4	1.34e-05	3	74	2	23555662
Pubmed	Influence of genetic polymorphisms of IL23R, STAT3, IL12B, and STAT4 on the risk of aplastic anemia and the effect of immunosuppressive therapy.	STAT3 STAT4	1.34e-05	3	74	2	29330562
Pubmed	Associations between STAT Gene Polymorphisms and Psoriasis in Northeastern China.	STAT3 STAT4	1.34e-05	3	74	2	28420002
Pubmed	Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice.	LDLR STAT3	1.34e-05	3	74	2	17109863
Pubmed	IL-23R-activated STAT3/STAT4 is essential for Th1/Th17-mediated CNS autoimmunity.	STAT3 STAT4	1.34e-05	3	74	2	28878115
Pubmed	Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-γ and STAT3 protein signaling pathways.	FBLIM1 STAT3	1.34e-05	3	74	2	22843679
Pubmed	Stat3 and Stat4: members of the family of signal transducers and activators of transcription.	STAT3 STAT4	1.34e-05	3	74	2	7545930
Pubmed	DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.	BCR STAT3	1.34e-05	3	74	2	34941574
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	CILP2 ADAMTS8 CUBN SSPOP	2.05e-05	75	74	4	20637190
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	AGRN LDLR PLXNA1	2.06e-05	25	74	3	17170699
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	2.67e-05	4	74	2	18849963
Pubmed	STATs as activators of apoptosis.	STAT3 STAT4	2.67e-05	4	74	2	9695817
Pubmed	Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.	STAT3 STAT4	2.67e-05	4	74	2	8140422
Pubmed	ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.	ADAMTS8 LDLR	2.67e-05	4	74	2	17606262
Pubmed	Promiscuous coupling of receptors to Gq class alpha subunits and effector proteins in pancreatic and submandibular gland cells.	GNA14 GNAQ	2.67e-05	4	74	2	9765251
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A2	2.67e-05	4	74	2	22419166
Pubmed	A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3.	STAT3 STAT4	2.67e-05	4	74	2	12426389
Pubmed	Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.	LDLR STAT3	2.67e-05	4	74	2	35440634
Pubmed	Immunity to retroviral infection: the Friend virus model.	APOBEC3D GNAQ	2.67e-05	4	74	2	9223268
Pubmed	Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR).	STAT3 STAT4	2.67e-05	4	74	2	15522880
Pubmed	Ligand-dependent serum response factor activation by the human CC chemokine receptors CCR2a and CCR2b is mediated by G proteins of the Gq family.	GNA14 GNAQ	2.67e-05	4	74	2	26823487
Pubmed	Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression.	NOS3 STAT3	2.67e-05	4	74	2	21183735
Pubmed	STATs and gene regulation.	STAT3 STAT4	2.67e-05	4	74	2	9287210
Pubmed	One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist.	CILP2 CILP	2.67e-05	4	74	2	12746903
Pubmed	Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.	GNA14 GNAQ	2.67e-05	4	74	2	9687499
Pubmed	Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells.	BCR STAT3	2.67e-05	4	74	2	18287094
Pubmed	Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells.	STAT3 STAT4	2.67e-05	4	74	2	19604309
Pubmed	Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase.	BCR STAT3	4.45e-05	5	74	2	9211920
Pubmed	BART is essential for nuclear retention of STAT3.	STAT3 STAT4	4.45e-05	5	74	2	18234692
Pubmed	Loss of gq/11 genes does not abolish melanopsin phototransduction.	GNA14 GNAQ	4.45e-05	5	74	2	24870805
Pubmed	STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells.	STAT3 STAT4	4.45e-05	5	74	2	24711622
Pubmed	Early Th1 cell differentiation is marked by a Tfh cell-like transition.	STAT3 STAT4	4.45e-05	5	74	2	22195747
Pubmed	Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities.	STAT3 STAT4	4.45e-05	5	74	2	19020307
Pubmed	The Current STATus of lymphocyte signaling: new roles for old players.	STAT3 STAT4	4.45e-05	5	74	2	19362457
Pubmed	Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways.	BCR STAT3	4.45e-05	5	74	2	28300289
Pubmed	Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.	STAT3 STAT4	4.45e-05	5	74	2	21953641
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	4.45e-05	5	74	2	24920589
Pubmed	A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.	RNF43 AKAP8L	4.45e-05	5	74	2	18313049
Pubmed	Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.	CILP2 LDLR TBL2	4.82e-05	33	74	3	18193044
Pubmed	Newly identified loci that influence lipid concentrations and risk of coronary artery disease.	CILP2 LDLR TBL2	5.76e-05	35	74	3	18193043
Pubmed	Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice.	LDLR STAT3	6.66e-05	6	74	2	24255059
Pubmed	N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.	STAT3 STAT4	6.66e-05	6	74	2	14704793
Pubmed	Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis.	LDLR STAT3	6.66e-05	6	74	2	24687132
Pubmed	Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke.	LDLR NOS3	6.66e-05	6	74	2	18622260
Pubmed	Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells.	GNA14 GNAQ	6.66e-05	6	74	2	8982657
Pubmed	Using siRNA to define functional interactions between melanopsin and multiple G Protein partners.	GNA14 GNAQ	6.66e-05	6	74	2	24958088
Pubmed	Association of STATs with relatives and friends.	STAT3 STAT4	6.66e-05	6	74	2	10675904
Pubmed	Polymorphisms in innate immunity genes and risk of childhood leukemia.	LPO NOS3 ABHD16A STAT3 STAT4	8.03e-05	206	74	5	20438785
Pubmed	Risk of meningioma and common variation in genes related to innate immunity.	LPO NOS3 ABHD16A STAT3 STAT4	8.21e-05	207	74	5	20406964
Pubmed	Common variation in genes related to innate immunity and risk of adult glioma.	LPO NOS3 ABHD16A STAT3 STAT4	8.40e-05	208	74	5	19423540
Pubmed	Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.	FCGBP KCNH2 LDLR NOS3	8.56e-05	108	74	4	19956635
Pubmed	Mechanisms of type-I- and type-II-interferon-mediated signalling.	STAT3 STAT4	9.31e-05	7	74	2	15864272
Pubmed	The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).	STAT3 STAT4	9.31e-05	7	74	2	9342212
Pubmed	MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23.	STAT3 STAT4	9.31e-05	7	74	2	33657395
Pubmed	STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.	STAT3 STAT4	9.31e-05	7	74	2	23797472
Pubmed	Signaling through the JAK/STAT pathway, recent advances and future challenges.	STAT3 STAT4	9.31e-05	7	74	2	12039028
Pubmed	JAK/STAT signaling by cytokine receptors.	STAT3 STAT4	9.31e-05	7	74	2	9638363
Pubmed	Physical and functional interactions between STAT3 and KAP1.	STAT3 STAT4	9.31e-05	7	74	2	18037959
Pubmed	Expression and activation of STAT proteins during mouse retina development.	STAT3 STAT4	9.31e-05	7	74	2	12634107
Pubmed	STAT heterodimers in immunity: A mixed message or a unique signal?	STAT3 STAT4	9.31e-05	7	74	2	24058793
Pubmed	Minireview: estrogen and mouse models of atherosclerosis.	LDLR NOS3	9.31e-05	7	74	2	12446574
Pubmed	Physiological significance of STAT proteins: investigations through gene disruption in vivo.	STAT3 STAT4	9.31e-05	7	74	2	10526573
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	1.24e-04	8	74	2	21165971
Pubmed	NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.	NOTUM RNF43	1.24e-04	8	74	2	34079124
Pubmed	Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.	STAT3 STAT4	1.24e-04	8	74	2	9989503
Pubmed	Evolution of the mammalian G protein alpha subunit multigene family.	GNA14 GNAQ BCR	1.59e-04	49	74	3	1302014
Pubmed	Genetic variants influencing circulating lipid levels and risk of coronary artery disease.	CILP2 LDLR TBL2	1.59e-04	49	74	3	20864672
Pubmed	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	GAMT CUBN NOS3	1.59e-04	49	74	3	19161160
Pubmed	The Jak-STAT pathway.	STAT3 STAT4	1.59e-04	9	74	2	10781830
Pubmed	The composition and signaling of the IL-35 receptor are unconventional.	STAT3 STAT4	1.59e-04	9	74	2	22306691
Pubmed	Protease-activated receptors in hemostasis, thrombosis and vascular biology.	GNA14 GNAQ	1.59e-04	9	74	2	16102047
Pubmed	Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator.	GNA14 GNAQ	1.59e-04	9	74	2	1322796
Pubmed	IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.	STAT3 STAT4	1.59e-04	9	74	2	16493033
Cytoband	9q21	GNA14 GNAQ	1.40e-04	11	74	2	9q21
Cytoband	17q21.31	LRRC37A LRRC37A2 STAT3	3.25e-04	82	74	3	17q21.31
Cytoband	16p13.3	METRN PRSS27 ZNF205 NUBP2	6.69e-04	244	74	4	16p13.3
Cytoband	15q15.3	STRC STRCP1	7.51e-04	25	74	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	TSSK6 CILP2 EFNA2 GAMT LDLR AKAP8L	1.83e-03	797	74	6	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	KCNH2 SSPOP NOS3	2.21e-03	159	74	3	chr7q36
Coexpression	NABA_ECM_GLYCOPROTEINS	CILP2 CILP VWA2 SSPOP AGRN OTOG	1.70e-05	191	74	6	MM17059
Coexpression	NABA_ECM_GLYCOPROTEINS	CILP2 CILP VWA2 SSPOP AGRN OTOG	1.97e-05	196	74	6	M3008
Coexpression	DESCARTES_FETAL_ADRENAL_SCHWANN_CELLS	METRN ADAMTS8 CSMD1 AGRN C2orf72	3.40e-05	130	74	5	M40147
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN NAV3 ZNF488 CSMD1 SSPOP OTOG	6.34e-07	184	74	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN NAV3 ZNF488 CSMD1 SSPOP OTOG	6.34e-07	184	74	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN NAV3 ZNF488 CSMD1 SSPOP OTOG	6.34e-07	184	74	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TSSK6 KCNH2 SBF2 MAP3K10 PIF1	4.83e-06	148	74	5	c240d506151fa90c59f40008c5fb31984c6f6f8f
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocye.Tnr.Cspg5_(Cspg5)\|Striatum / BrainAtlas - Mouse McCarroll V32	CILP2 ZAN LPO OTOG	5.69e-06	70	74	4	c6d3f8cd3f79e2beb826b07a6b9f3ab35d4f23ea
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocye.Tnr.Cspg5_(Cspg5)-\|Striatum / BrainAtlas - Mouse McCarroll V32	CILP2 ZAN LPO OTOG	5.69e-06	70	74	4	823921f8bf585d45f24f627b2b77b228898eb85a
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P3-Tnr\|Striatum / BrainAtlas - Mouse McCarroll V32	CILP2 ZAN LPO OTOG	5.69e-06	70	74	4	d2be16550c572ba77261c978648e61dba3eab6bd
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P3\|Striatum / BrainAtlas - Mouse McCarroll V32	CILP2 ZAN LPO OTOG	5.69e-06	70	74	4	52bde49a05f2387fe3e4357422e155bee2e86ae6
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	NOTUM NLRX1 LRRC37A2 LRRC7 RNF43	9.47e-06	170	74	5	fefb07a7e308b620f946b9ff2b01e1796446fe38
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SMCHD1 PPP1R15B LDLR STAT3 STAT4	1.70e-05	192	74	5	47646d7e4990be85072987f92bf18d52f8da752e
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	5.71e-06	2	71	2	DOID:0110471 (implicated_via_orthology)
Disease	rectum adenocarcinoma (is_implicated_in)	STAT3 STAT4	1.71e-05	3	71	2	DOID:1996 (is_implicated_in)
Disease	Acute Q fever	LSS LDLR	5.68e-05	5	71	2	C0519066
Disease	Chronic Q Fever	LSS LDLR	5.68e-05	5	71	2	C1443892
Disease	Q Fever	LSS LDLR	5.68e-05	5	71	2	C0034362
Disease	Coxiella burnetii Infection	LSS LDLR	5.68e-05	5	71	2	C2973787
Disease	Behcet's disease (is_implicated_in)	NOS3 STAT3 STAT4	9.00e-05	36	71	3	DOID:13241 (is_implicated_in)
Disease	obesity (implicated_via_orthology)	GNA14 ADAMTS8 GNAQ STAT3 STAT4	1.73e-04	215	71	5	DOID:9970 (implicated_via_orthology)
Disease	psoriatic arthritis (is_implicated_in)	STAT3 STAT4	3.10e-04	11	71	2	DOID:9008 (is_implicated_in)
Disease	lymphangioleiomyomatosis (is_marker_for)	NOS3 STAT3	3.71e-04	12	71	2	DOID:3319 (is_marker_for)
Disease	Atherosclerosis	LDLR NOS3 STAT3	3.94e-04	59	71	3	C0004153
Disease	Atherogenesis	LDLR NOS3 STAT3	3.94e-04	59	71	3	C1563937
Disease	N-acetyl-isoputreanine measurement	MTG1 KCNH2	4.38e-04	13	71	2	EFO_0800107
Disease	Lipidemias	LDLR NOS3	7.58e-04	17	71	2	C1706412
Disease	Hyperlipidemia	LDLR NOS3	7.58e-04	17	71	2	C0020473
Disease	physical activity	CRYBG2 LRRC7 CSMD1	1.27e-03	88	71	3	EFO_0003940
Disease	albuminuria	SBF2 CUBN CSMD1	1.53e-03	94	71	3	EFO_0004285
Disease	cholesteryl ester 14:0 measurement	NAV3 LDLR	1.93e-03	27	71	2	EFO_0010340
Disease	hepatitis C (is_implicated_in)	IFNL4 LDLR	2.07e-03	28	71	2	DOID:1883 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WFCGNRLPANRRFQI	APOBEC3D	86	Q96AK3
RCQANGTWNIGDERP	CSMD1	2601	Q96PZ7
GPWSRRKNQDVAACR	C2orf72	231	A6NCS6
DRQRWGFRRAAQAPD	BCR	71	P11274
GWQRRTVECRDPSGQ	ADAMTS8	851	Q9UP79
ACLRGIGRWTNPQYR	ABHD16A	111	O95870
LRCDRCEPGFWNFRG	AGRN	821	O00468
RGNDTFGPRAQGWAR	AKAP8L	171	Q9ULX6
QCDRGWAPVFLDREQ	NUBP2	71	Q9Y5Y2
WAAVRARGCQFLGPA	RC3H2	181	Q9HBD1
WNDPGIQECYDRRRE	GNAQ	136	P50148
EQRRWLDGLFFPRAG	MAP3K10	701	Q02779
LPWRGCSSRRESQDG	LRRC37A2	1626	A6NM11
LPWRGCSSRRESQDG	LRRC37A	1626	A6NMS7
AGQREVCWEQQLRPG	NCKAP5L	151	Q9HCH0
WSRFGEARLGCAPRF	METRN	256	Q9UJH8
ELFCQPGGWQLSRER	SBF2	46	Q86WG5
CQAPWERGQRGITLQ	LRRC7	481	Q96NW7
LQCRRRQRGDAGSPW	MESP2	146	Q0VG99
WGDSRGRQYQELPRC	KCNH2	1001	Q12809
AAQAAWRENFPLCGR	MTG1	11	Q9BT17
PGFGENARVLDWICR	PCK2	546	Q16822
VGGRPCSFSWRNSRE	PLXNA1	996	Q9UIW2
LQRQFVVRAWGCAGP	PINK1	81	Q9BXM7
QRCRDHGQPGYNSWR	LPO	556	P22079
TWRLGQACPRLQAGD	NAV3	741	Q8IVL0
QFRVCARGDGRQEWS	CRLF3	246	Q8IUI8
FCRRQQRADGSWEGS	LSS	566	P48449
PFQRRSVAGRWGCSG	MROH6	701	A6NGR9
FARGALAWCRQRNPN	KLLN	91	B2CW77
SWGSGFRRALQRPDD	NLRX1	11	Q86UT6
FPQRCPGRGDFRIWN	NOS3	231	P29474
RYWNGVVPERCRRQF	NOTUM	296	Q6P988
GRGFTVRWETQQPEC	CUBN	576	O60494
QGFRAESRCWRYDPR	KLHL22	361	Q53GT1
VVGRQRYGRPVDCWA	CAMKV	191	Q8NCB2
VWCRNRIPVEGNFGQ	DCST1	301	Q5T197
ACQAAGAQLREWRRP	FCGBP	2316	Q9Y6R7
GAQLREWRRPDFCPF	FCGBP	2321	Q9Y6R7
AGAQLREWRRPDFCP	FCGBP	3521	Q9Y6R7
RNWGGPDFERVRCGL	CCDC9	221	Q9Y3X0
DQGRAPDARACELWQ	CRYBG2	316	Q8N1P7
SWGQRNCSFRPRRDP	IFNL4	56	K9M1U5
CNDGVFQRLRDWAPR	GAMT	91	Q14353
QRGFKRWECNRPAAP	EFNA2	106	O43921
RQAVCEARRGRPWEA	FBLIM1	31	Q8WUP2
ANDGWRCPRGNDRYR	SCAF11	971	Q99590
WCRFNLRVNPRLEAG	NEURL4	1396	Q96JN8
ARACAQAGRPLQGWR	OTOG	396	Q6ZRI0
LWQDPGIQECYDRRR	GNA14	131	O95837
ALAQRPGVRQGWLNC	PIF1	286	Q9H611
RGKRPIFECFWNGRL	SMCHD1	466	A6NHR9
VPCSGGFRLRWREAE	SSPOP	4631	A2VEC9
SDWCRGRLQDREGIF	SH3D19	696	Q5HYK7
FCWDRSQKRRRPSGQ	PIANP	201	Q8IYJ0
RRYQASCRQARGEWP	RNF43	246	Q68DV7
PWEEFARDGCRFQKR	PPP1R15B	661	Q5SWA1
NCSFWDAFRPEGRRS	STRC	656	Q7RTU9
GSPREGFWCLNREQR	CILP	111	O75339
NPTRGFWCLNREQPR	CILP2	116	Q8IUL8
ACGEAFAWRALRIPQ	ZNF837	201	Q96EG3
ENRWRLSEPELGRGC	ZNF488	31	Q96MN9
WNLEKRDGGNPLCTR	VPS11	116	Q9H270
VISWGEGCARQNRPG	PRSS27	246	Q9BQR3
ADWKRRQQIACIGGP	STAT3	241	P40763
QDWKRRQQIACIGGP	STAT4	236	Q14765
FSREEWGCLRPAQRA	ZNF747	46	Q9BV97
REFAGNAPCWRGSRR	VWA2	251	Q5GFL6
RNGNQDCRNRRPPWS	ZNFX1	106	Q9P2E3
VGRCSDPNLGLSWRQ	nan	136	Q8NA96
FRTRAGRVQWGVPQC	ZNF205	221	O95201
PSAGQVARNCWLRAG	TSSK6	256	Q9BXA6
NCSFWDAFRPEGRRS	STRCP1	656	A6NGW2
LRNRGPGCTWDSLRN	TARBP2	256	Q15633
WLRAGEERSGRPACQ	TBL2	31	Q9Y4P3
PWRCRAQEFCGQQDG	ZAN	1516	Q9Y493
GGRVNRCIPQFWRCD	LDLR	76	P01130