Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionP-type sodium transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

3.60e-1110565GO:0008554
GeneOntologyMolecularFunctionP-type sodium:potassium-exchanging transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

3.60e-1110565GO:0005391
GeneOntologyMolecularFunctionP-type potassium transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

6.59e-1111565GO:0008556
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

5.10e-0836565GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

5.10e-0836565GO:0015662
GeneOntologyMolecularFunctionsteroid hormone binding

ATP1A1 ATP1A2 ATP1A3

7.25e-077563GO:1990239
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

8.28e-0762565GO:0019829
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.35e-05109565GO:0042626
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.04e-04167565GO:0015079
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.17e-04171565GO:0015081
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.41e-04178565GO:0015399
GeneOntologyMolecularFunctionATP hydrolysis activity

CHD8 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 DDX41

2.23e-04441567GO:0016887
GeneOntologyMolecularFunctionpotassium ion binding

ATP1A1 ATP1A2

6.88e-0414562GO:0030955
GeneOntologyMolecularFunctionsodium ion binding

ATP1A1 ATP1A2

6.88e-0414562GO:0031402
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

EPHB2 CLK3 CLK4 EPHA3

7.31e-04145564GO:0004713
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHB2 EPHA3

7.92e-0415562GO:0005005
GeneOntologyMolecularFunctionneurexin family protein binding

NLGN4X NLGN4Y

9.04e-0416562GO:0042043
GeneOntologyMolecularFunctionchloride ion binding

NLGN4X NLGN4Y

9.04e-0416562GO:0031404
GeneOntologyMolecularFunctionprotein-folding chaperone binding

ATP1A1 ATP1A2 ATP1A3 SLC25A17

1.08e-03161564GO:0051087
GeneOntologyMolecularFunctionephrin receptor activity

EPHB2 EPHA3

1.28e-0319562GO:0005003
GeneOntologyMolecularFunctiontransmembrane transporter binding

TCAF1 ACTN2 ATP1A1 AGRN

1.38e-03172564GO:0044325
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.53e-03301565GO:0022853
GeneOntologyMolecularFunctionATP-dependent activity

CHD8 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 DDX41

1.58e-03614567GO:0140657
GeneOntologyMolecularFunctioncyclase activity

TKFC GUCY1A1

2.05e-0324562GO:0009975
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 SLC25A17

2.13e-03477566GO:0022804
GeneOntologyMolecularFunctionphosphorus-oxygen lyase activity

TKFC GUCY1A1

2.22e-0325562GO:0016849
GeneOntologyMolecularFunctionalkali metal ion binding

ATP1A1 ATP1A2

2.40e-0326562GO:0031420
GeneOntologyMolecularFunctionheparan sulfate proteoglycan binding

ATP1A3 AGRN

2.99e-0329562GO:0043395
GeneOntologyMolecularFunctionhormone binding

ATP1A1 ATP1A2 ATP1A3

3.03e-03103563GO:0042562
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

EPHB2 TKFC CLK3 CLK4 TUT1 LRRK1 PALS2 EPHA3

4.42e-03938568GO:0016772
GeneOntologyMolecularFunctionkinase activity

EPHB2 TKFC CLK3 CLK4 LRRK1 PALS2 EPHA3

5.31e-03764567GO:0016301
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

CHD8 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 DDX41

5.73e-03775567GO:0017111
GeneOntologyMolecularFunctionsteroid binding

ATP1A1 ATP1A2 ATP1A3

6.19e-03133563GO:0005496
GeneOntologyMolecularFunctionprotein serine/threonine/tyrosine kinase activity

CLK3 CLK4

7.70e-0347562GO:0004712
GeneOntologyMolecularFunctionpyrophosphatase activity

CHD8 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 DDX41

8.72e-03839567GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

CHD8 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 DDX41

8.77e-03840567GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

CHD8 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 DDX41

8.77e-03840567GO:0016818
GeneOntologyMolecularFunctionproteoglycan binding

ATP1A3 AGRN

9.02e-0351562GO:0043394
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

9.66e-03465565GO:0046873
GeneOntologyBiologicalProcesssodium ion export across plasma membrane

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 AGRN

4.11e-1217576GO:0036376
GeneOntologyBiologicalProcessestablishment or maintenance of transmembrane electrochemical gradient

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

6.14e-1111575GO:0010248
GeneOntologyBiologicalProcessintracellular potassium ion homeostasis

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

8.12e-1017575GO:0030007
GeneOntologyBiologicalProcessintracellular sodium ion homeostasis

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.82e-0830575GO:0006883
GeneOntologyBiologicalProcesspotassium ion homeostasis

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

5.49e-0837575GO:0055075
GeneOntologyBiologicalProcessexport across plasma membrane

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 AGRN

1.89e-0791576GO:0140115
GeneOntologyBiologicalProcessresponse to glycoside

ATP1A1 ATP1A2 ATP1A3

1.99e-075573GO:1903416
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

2.87e-0751575GO:1990573
GeneOntologyBiologicalProcesssodium ion homeostasis

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

2.87e-0751575GO:0055078
GeneOntologyBiologicalProcesspostsynaptic membrane assembly

EPHB2 NLGN4X NLGN4Y

3.25e-0611573GO:0097104
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

ACTN2 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 AGRN

3.41e-06232577GO:0071805
GeneOntologyBiologicalProcesspotassium ion transport

ACTN2 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 AGRN

9.67e-06272577GO:0006813
GeneOntologyBiologicalProcesspostsynaptic membrane organization

EPHB2 NLGN4X NLGN4Y AGRN

1.73e-0556574GO:0001941
GeneOntologyBiologicalProcessterritorial aggressive behavior

NLGN4X NLGN4Y

2.25e-053572GO:0002124
GeneOntologyBiologicalProcesssodium ion transmembrane transport

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 AGRN

2.31e-05208576GO:0035725
GeneOntologyBiologicalProcessmale courtship behavior

NLGN4X NLGN4Y

4.49e-054572GO:0008049
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

4.52e-05142575GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

4.52e-05142575GO:0098659
GeneOntologyBiologicalProcesscell communication by electrical coupling involved in cardiac conduction

ATP1A1 ATP1A2 ATP1A3

4.97e-0526573GO:0086064
GeneOntologyBiologicalProcesssocial behavior

NLGN4X NLGN4Y CHD8 ATP1A3

5.22e-0574574GO:0035176
GeneOntologyBiologicalProcessbiological process involved in intraspecies interaction between organisms

NLGN4X NLGN4Y CHD8 ATP1A3

5.80e-0576574GO:0051703
GeneOntologyBiologicalProcessregulation of monoatomic ion transmembrane transporter activity

EPHB2 TCAF1 AHNAK ACTN2 ATP1A2 AGRN

7.36e-05256576GO:0032412
GeneOntologyBiologicalProcessregulation of transmembrane transporter activity

EPHB2 TCAF1 AHNAK ACTN2 ATP1A2 AGRN

9.09e-05266576GO:0022898
GeneOntologyBiologicalProcessnegative regulation of ion transmembrane transporter activity

EPHB2 ACTN2 ATP1A2 AGRN

9.83e-0587574GO:0032413
GeneOntologyBiologicalProcessproton transmembrane transport

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.06e-04170575GO:1902600
GeneOntologyBiologicalProcesssodium ion transport

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 AGRN

1.09e-04275576GO:0006814
GeneOntologyBiologicalProcesscell communication by electrical coupling

ATP1A1 ATP1A2 ATP1A3

1.23e-0435573GO:0010644
GeneOntologyBiologicalProcesscourtship behavior

NLGN4X NLGN4Y

1.56e-047572GO:0007619
GeneOntologyBiologicalProcessregulation of transporter activity

EPHB2 TCAF1 AHNAK ACTN2 ATP1A2 AGRN

1.72e-04299576GO:0032409
GeneOntologyBiologicalProcessbrainstem development

NLGN4X NLGN4Y

2.08e-048572GO:0003360
GeneOntologyBiologicalProcessfatty acid alpha-oxidation

HAO1 SLC25A17

2.08e-048572GO:0001561
GeneOntologyBiologicalProcessrelaxation of muscle

GUCY1A1 ATP1A1 ATP1A2

2.13e-0442573GO:0090075
GeneOntologyBiologicalProcessnegative regulation of transporter activity

EPHB2 ACTN2 ATP1A2 AGRN

2.43e-04110574GO:0032410
GeneOntologyBiologicalProcesspeptidyl-tyrosine phosphorylation

EPHB2 CLK3 CLK4 LRRK1 AGRN EPHA3

2.79e-04327576GO:0018108
GeneOntologyBiologicalProcesspeptidyl-tyrosine modification

EPHB2 CLK3 CLK4 LRRK1 AGRN EPHA3

2.88e-04329576GO:0018212
GeneOntologyBiologicalProcesslearning

EPHB2 NLGN4X NLGN4Y ATP1A2 ATP1A3

2.97e-04212575GO:0007612
GeneOntologyBiologicalProcesspresynaptic membrane assembly

NLGN4X NLGN4Y

3.33e-0410572GO:0097105
GeneOntologyBiologicalProcessnegative regulation of monoatomic ion transmembrane transport

EPHB2 ACTN2 ATP1A2 AGRN

3.84e-04124574GO:0034766
GeneOntologyBiologicalProcessregulation of cardiac muscle cell membrane potential

ATP1A3 AGRN

4.06e-0411572GO:0086036
GeneOntologyBiologicalProcessimport across plasma membrane

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

4.31e-04230575GO:0098739
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

EPHB2 NLGN4X GUCY1A1 NLGN4Y CFL1 ATP1A2 ATP1A3 AGRN

4.49e-04663578GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

EPHB2 NLGN4X GUCY1A1 NLGN4Y CFL1 ATP1A2 ATP1A3 AGRN

4.54e-04664578GO:0099177
GeneOntologyBiologicalProcesspositive regulation of protein localization to membrane

EPHB2 TCAF1 AGRN EPHA3

4.60e-04130574GO:1905477
GeneOntologyBiologicalProcesspresynaptic membrane organization

NLGN4X NLGN4Y

5.74e-0413572GO:0097090
GeneOntologyBiologicalProcessaggressive behavior

NLGN4X NLGN4Y

5.74e-0413572GO:0002118
GeneOntologyBiologicalProcesscell communication involved in cardiac conduction

ATP1A1 ATP1A2 ATP1A3

5.83e-0459573GO:0086065
GeneOntologyBiologicalProcesspositive regulation of actin filament depolymerization

CFL1 ACTN2

6.68e-0414572GO:0030836
GeneOntologyBiologicalProcesspositive regulation of synaptic plasticity

EPHB2 CFL1

6.68e-0414572GO:0031915
GeneOntologyBiologicalProcessmembrane assembly

EPHB2 NLGN4X NLGN4Y

7.40e-0464573GO:0071709
GeneOntologyBiologicalProcessmale mating behavior

NLGN4X NLGN4Y

7.70e-0415572GO:0060179
GeneOntologyBiologicalProcessmuscle contraction

GUCY1A1 ACTN2 ATP1A1 ATP1A2 ATP1A3 AGRN

8.07e-04400576GO:0006936
GeneOntologyBiologicalProcessfear response

EPHB2 ATP1A2 ATP1A3

8.09e-0466573GO:0042596
GeneOntologyBiologicalProcessregulation of membrane potential

NLGN4X ACTN2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 AGRN

8.46e-04559577GO:0042391
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

EPHB2 TCAF1 AHNAK ACTN2 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 AGRN

8.67e-0411155710GO:0034220
GeneOntologyBiologicalProcessnegative regulation of sodium ion transmembrane transporter activity

ATP1A2 AGRN

8.78e-0416572GO:2000650
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NLGN4X NLGN4Y

8.78e-0416572GO:0007158
GeneOntologyBiologicalProcessL-ascorbic acid metabolic process

ATP1A2 ATP1A3

8.78e-0416572GO:0019852
GeneOntologyBiologicalProcesscell junction assembly

EPHB2 NLGN4X NLGN4Y CFL1 ACTN2 AGRN EPHA3

9.38e-04569577GO:0034329
GeneOntologyBiologicalProcessnegative regulation of sodium ion transmembrane transport

ATP1A2 AGRN

9.94e-0417572GO:1902306
GeneOntologyBiologicalProcessregulation of monoatomic ion transmembrane transport

EPHB2 TCAF1 AHNAK ACTN2 ATP1A2 AGRN

1.00e-03417576GO:0034765
GeneOntologyBiologicalProcessregulation of monoatomic ion transport

EPHB2 TCAF1 AHNAK ACTN2 ATP1A1 ATP1A2 AGRN

1.02e-03577577GO:0043269
GeneOntologyBiologicalProcessmembrane biogenesis

EPHB2 NLGN4X NLGN4Y

1.09e-0373573GO:0044091
GeneOntologyBiologicalProcesswater-soluble vitamin metabolic process

FPGS ATP1A2 ATP1A3

1.13e-0374573GO:0006767
GeneOntologyBiologicalProcesscardiac muscle contraction

ATP1A1 ATP1A2 ATP1A3 AGRN

1.17e-03167574GO:0060048
GeneOntologyBiologicalProcesscGMP metabolic process

GUCY1A1 PDE10A

1.24e-0319572GO:0046068
GeneOntologyBiologicalProcesslactone metabolic process

ATP1A2 ATP1A3

1.24e-0319572GO:1901334
GeneOntologyBiologicalProcessnegative regulation of monoatomic ion transport

EPHB2 ACTN2 ATP1A2 AGRN

1.28e-03171574GO:0043271
GeneOntologyBiologicalProcessnegative regulation of transmembrane transport

EPHB2 ACTN2 ATP1A2 AGRN

1.39e-03175574GO:0034763
GeneOntologyBiologicalProcessrelaxation of cardiac muscle

ATP1A1 ATP1A2

1.52e-0321572GO:0055119
GeneOntologyBiologicalProcesspositive regulation of protein depolymerization

CFL1 ACTN2

1.52e-0321572GO:1901881
GeneOntologyBiologicalProcessresponse to potassium ion

ATP1A2 ATP1A3

1.52e-0321572GO:0035864
GeneOntologyBiologicalProcessregulation of cell junction assembly

EPHB2 NLGN4X CFL1 AGRN EPHA3

1.62e-03309575GO:1901888
GeneOntologyBiologicalProcessnegative regulation of sodium ion transport

ATP1A2 AGRN

1.67e-0322572GO:0010766
GeneOntologyBiologicalProcesspostsynapse organization

EPHB2 NLGN4X NLGN4Y CFL1 AGRN

1.71e-03313575GO:0099173
GeneOntologyBiologicalProcessregulation of cardiac muscle contraction

ATP1A1 ATP1A2 AGRN

1.92e-0389573GO:0055117
GeneOntologyBiologicalProcessvocalization behavior

NLGN4X NLGN4Y

1.99e-0324572GO:0071625
GeneOntologyBiologicalProcesspostsynapse assembly

EPHB2 NLGN4X NLGN4Y

2.18e-0393573GO:0099068
GeneOntologyBiologicalProcesstrans-synaptic signaling, modulating synaptic transmission

EPHB2 GUCY1A1

2.34e-0326572GO:0099550
GeneOntologyBiologicalProcessregulation of muscle contraction

GUCY1A1 ATP1A1 ATP1A2 AGRN

2.35e-03202574GO:0006937
GeneOntologyBiologicalProcessfocal adhesion assembly

CFL1 ACTN2 EPHA3

2.45e-0397573GO:0048041
GeneOntologyBiologicalProcesspositive regulation of ion transmembrane transporter activity

EPHB2 TCAF1 ACTN2

2.45e-0397573GO:0032414
GeneOntologyBiologicalProcesscardiac conduction

ATP1A1 ATP1A2 ATP1A3

2.68e-03100573GO:0061337
GeneOntologyBiologicalProcessneuron projection fasciculation

EPHB2 EPHA3

2.71e-0328572GO:0106030
GeneOntologyBiologicalProcessaxonal fasciculation

EPHB2 EPHA3

2.71e-0328572GO:0007413
GeneOntologyBiologicalProcessregulation of sodium ion transport

ATP1A1 ATP1A2 AGRN

2.75e-03101573GO:0002028
GeneOntologyCellularComponentsodium:potassium-exchanging ATPase complex

ATP1A1 ATP1A2 ATP1A3 ATP1A4

2.79e-0812594GO:0005890
GeneOntologyCellularComponentcation-transporting ATPase complex

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

2.61e-0749595GO:0090533
GeneOntologyCellularComponentATPase dependent transmembrane transport complex

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

4.70e-0755595GO:0098533
GeneOntologyCellularComponentsymmetric, GABA-ergic, inhibitory synapse

NLGN4X NLGN4Y

4.68e-054592GO:0098983
GeneOntologyCellularComponentphotoreceptor inner segment membrane

ATP1A1 ATP1A3

4.68e-054592GO:0060342
GeneOntologyCellularComponentsarcolemma

AHNAK ATP1A1 ATP1A2 ATP1A3 AGRN

1.98e-04190595GO:0042383
GeneOntologyCellularComponentcell-cell junction

EPPK1 MPP4 CFL1 AHNAK ATP1A1 ATP1A2 PALS2 PDZD2

2.42e-04591598GO:0005911
GeneOntologyCellularComponentanchoring junction

FLNB EPPK1 MPP4 CFL1 AHNAK ACTN2 ATP1A1 ATP1A2 PALS2 PDZD2

3.68e-049765910GO:0070161
GeneOntologyCellularComponentsomatodendritic compartment

EPHB2 FLNB NLGN4X NLGN4Y CFL1 ACTN2 ATP1A2 ATP1A3 PDE10A EPHA3 PMM2

5.68e-0412285911GO:0036477
GeneOntologyCellularComponentsymmetric synapse

NLGN4X NLGN4Y

5.99e-0413592GO:0032280
GeneOntologyCellularComponentdendritic spine

EPHB2 CFL1 ACTN2 ATP1A2 ATP1A3

6.00e-04242595GO:0043197
GeneOntologyCellularComponentneuron to neuron synapse

EPHB2 NLGN4X NLGN4Y CFL1 ACTN2 ATP1A1 ATP1A3

6.53e-04523597GO:0098984
GeneOntologyCellularComponentneuron spine

EPHB2 CFL1 ACTN2 ATP1A2 ATP1A3

6.58e-04247595GO:0044309
GeneOntologyCellularComponentmicrobody membrane

PEX14 HSD17B4 SLC25A17

9.80e-0469593GO:0031903
GeneOntologyCellularComponentperoxisomal membrane

PEX14 HSD17B4 SLC25A17

9.80e-0469593GO:0005778
GeneOntologyCellularComponentmicrobody

PEX14 HAO1 HSD17B4 SLC25A17

1.14e-03162594GO:0042579
GeneOntologyCellularComponentperoxisome

PEX14 HAO1 HSD17B4 SLC25A17

1.14e-03162594GO:0005777
GeneOntologyCellularComponentactin cytoskeleton

FLNB MPP4 CFL1 AHNAK ACTN2 ATP12A EPHA3

1.15e-03576597GO:0015629
GeneOntologyCellularComponentGABA-ergic synapse

NLGN4X GUCY1A1 NLGN4Y EPHA3

1.19e-03164594GO:0098982
GeneOntologyCellularComponentsynaptic membrane

EPHB2 NLGN4X MPP4 NLGN4Y CFL1 ACTN2 ATP1A3

1.23e-03583597GO:0097060
GeneOntologyCellularComponentglycinergic synapse

NLGN4X NLGN4Y

1.44e-0320592GO:0098690
GeneOntologyCellularComponentT-tubule

AHNAK ATP1A1 ATP1A2

1.45e-0379593GO:0030315
GeneOntologyCellularComponentglutamatergic synapse

EPHB2 NLGN4X GUCY1A1 NLGN4Y CFL1 ACTN2 PDE10A AGRN

2.00e-03817598GO:0098978
GeneOntologyCellularComponentasymmetric, glutamatergic, excitatory synapse

NLGN4X NLGN4Y

2.08e-0324592GO:0098985
GeneOntologyCellularComponentcell-cell contact zone

AHNAK ATP1A1 ATP1A2

2.39e-0394593GO:0044291
GeneOntologyCellularComponentdendrite

EPHB2 NLGN4X NLGN4Y CFL1 ACTN2 ATP1A2 ATP1A3 EPHA3

2.71e-03858598GO:0030425
GeneOntologyCellularComponentdendritic tree

EPHB2 NLGN4X NLGN4Y CFL1 ACTN2 ATP1A2 ATP1A3 EPHA3

2.75e-03860598GO:0097447
GeneOntologyCellularComponentinhibitory synapse

NLGN4X NLGN4Y

3.45e-0331592GO:0060077
GeneOntologyCellularComponenttransporter complex

PEX14 ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

4.47e-03550596GO:1990351
HumanPhenoIncreased circulating very long-chain fatty acid concentration

BCAP31 PEX14 HSD17B4

1.74e-0510283HP:0033643
HumanPhenoEpisodic quadriplegia

ATP1A2 ATP1A3

2.91e-052282HP:0200072
DomainP-type_ATPase_IIC

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.21e-126565IPR005775
Domain-

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

8.60e-10165651.20.1110.10
DomainATPase_P-typ_TM_dom

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

8.60e-1016565IPR023298
DomainATPase_P-typ_cation-transptr_C

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.22e-0917565IPR006068
DomainCation_ATPase_C

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.22e-0917565PF00689
DomainCation_ATPase_N

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.68e-0918565PF00690
DomainCation_ATPase_N

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.68e-0918565SM00831
DomainATPase_P-typ_cation-transptr_N

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

2.27e-0919565IPR004014
Domain-

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

3.82e-08325653.40.1110.10
Domain-

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

3.82e-08325652.70.150.10
DomainATPase_P-typ_cyto_domN

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

6.12e-0835565IPR023299
DomainP_typ_ATPase

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

7.09e-0836565IPR001757
DomainATPase_P-typ_P_site

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

7.09e-0836565IPR018303
DomainATPASE_E1_E2

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

7.09e-0836565PS00154
DomainATPase_P-typ_transduc_dom_A

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

8.18e-0837565IPR008250
DomainE1-E2_ATPase

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

8.18e-0837565PF00122
DomainHAD-like_dom

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4 PMM2

1.30e-0779566IPR023214
DomainNLGN4

NLGN4X NLGN4Y

8.83e-062562IPR030025
DomainNlgn

NLGN4X NLGN4Y

8.78e-055562IPR000460
DomainL27_C

MPP4 PALS2

3.91e-0410562IPR014775
DomainL27

MPP4 PALS2

3.91e-0410562PF02828
DomainEphrin_rec_like

EPHB2 EPHA3

4.77e-0411562PF07699
DomainL27

MPP4 PALS2

6.74e-0413562SM00569
DomainL27

MPP4 PALS2

6.74e-0413562PS51022
DomainL27_dom

MPP4 PALS2

6.74e-0413562IPR004172
DomainCarboxylesterase_B_CS

NLGN4X NLGN4Y

6.74e-0413562IPR019819
DomainRECEPTOR_TYR_KIN_V_2

EPHB2 EPHA3

7.85e-0414562PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB2 EPHA3

7.85e-0414562PS00790
DomainEph_TM

EPHB2 EPHA3

7.85e-0414562IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHB2 EPHA3

7.85e-0414562IPR001426
DomainCARBOXYLESTERASE_B_2

NLGN4X NLGN4Y

7.85e-0414562PS00941
DomainEPH_lbd

EPHB2 EPHA3

7.85e-0414562SM00615
DomainEphrin_lbd

EPHB2 EPHA3

7.85e-0414562PF01404
DomainEphA2_TM

EPHB2 EPHA3

7.85e-0414562PF14575
DomainTyr_kinase_ephrin_rcpt

EPHB2 EPHA3

7.85e-0414562IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHB2 EPHA3

7.85e-0414562IPR001090
DomainEPH_LBD

EPHB2 EPHA3

7.85e-0414562PS51550
DomainCOesterase

NLGN4X NLGN4Y

7.85e-0414562PF00135
DomainCarbesteraseB

NLGN4X NLGN4Y

7.85e-0414562IPR002018
DomainPDZ

MPP4 AHNAK PALS2 PDZD2

8.43e-04141564PF00595
DomainPDZ

MPP4 AHNAK PALS2 PDZD2

1.01e-03148564SM00228
DomainGuanylate_kinase_CS

MPP4 PALS2

1.03e-0316562IPR020590
Domain-

MPP4 AHNAK PALS2 PDZD2

1.06e-031505642.30.42.10
DomainPDZ

MPP4 AHNAK PALS2 PDZD2

1.09e-03151564PS50106
DomainPDZ

MPP4 AHNAK PALS2 PDZD2

1.11e-03152564IPR001478
DomainActinin_actin-bd_CS

FLNB ACTN2

2.15e-0323562IPR001589
DomainGUANYLATE_KINASE_2

MPP4 PALS2

2.15e-0323562PS50052
DomainGUANYLATE_KINASE_1

MPP4 PALS2

2.15e-0323562PS00856
DomainACTININ_2

FLNB ACTN2

2.15e-0323562PS00020
DomainACTININ_1

FLNB ACTN2

2.15e-0323562PS00019
DomainSAM

EPHB2 SAMD12 EPHA3

2.34e-0388563SM00454
DomainEphrin_rec_like

EPHB2 EPHA3

2.53e-0325562SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB2 EPHA3

2.53e-0325562IPR011641
DomainGuanylate_kin

MPP4 PALS2

2.74e-0326562PF00625
DomainGK/Ca_channel_bsu

MPP4 PALS2

2.74e-0326562IPR008145
DomainGuanylate_kin-like_dom

MPP4 PALS2

2.74e-0326562IPR008144
DomainGuKc

MPP4 PALS2

2.74e-0326562SM00072
DomainSAM_DOMAIN

EPHB2 SAMD12 EPHA3

2.91e-0395563PS50105
DomainSAM

EPHB2 SAMD12 EPHA3

3.08e-0397563IPR001660
DomainAden_trnslctor

SLC25A44 SLC25A17

3.17e-0328562IPR002113
Domain-

EPHB2 SAMD12 EPHA3

3.96e-031065631.10.150.50
DomainMit_carrier

SLC25A44 SLC25A17

4.13e-0332562IPR002067
DomainSAM/pointed

EPHB2 SAMD12 EPHA3

5.22e-03117563IPR013761
PathwayKEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION

ATP1A1 ATP1A2 ATP1A3 ATP1A4

7.00e-0723444M4361
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

7.26e-0755445M971
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

8.70e-0757445MM15643
PathwayKEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION

ATP1A1 ATP1A2 ATP1A3 ATP1A4

8.47e-0642444M16473
PathwayREACTOME_MUSCLE_CONTRACTION

GUCY1A1 ACTN2 ATP1A1 ATP1A2 ATP1A3 ATP1A4

1.15e-05165446MM15026
PathwayREACTOME_ION_HOMEOSTASIS

ATP1A1 ATP1A2 ATP1A3 ATP1A4

2.33e-0554444M27460
PathwayREACTOME_ION_HOMEOSTASIS

ATP1A1 ATP1A2 ATP1A3 ATP1A4

2.33e-0554444MM15202
PathwayREACTOME_MUSCLE_CONTRACTION

GUCY1A1 ACTN2 ATP1A1 ATP1A2 ATP1A3 ATP1A4

3.71e-05203446M5485
PathwayKEGG_PEROXISOME

PEX14 HAO1 HSD17B4 SLC25A17

9.95e-0578444M6391
PathwayKEGG_CARDIAC_MUSCLE_CONTRACTION

ATP1A1 ATP1A2 ATP1A3 ATP1A4

1.05e-0479444M17673
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

2.10e-04176445MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

2.51e-04183445M997
PathwayREACTOME_CARDIAC_CONDUCTION

ATP1A1 ATP1A2 ATP1A3 ATP1A4

2.91e-04103444MM15196
PathwayREACTOME_PROTEIN_LOCALIZATION

PEX14 HAO1 HSD17B4 SLC25A17

2.91e-04103444MM15653
PathwayREACTOME_CARDIAC_CONDUCTION

ATP1A1 ATP1A2 ATP1A3 ATP1A4

7.04e-04130444M27454
PathwayREACTOME_PEROXISOMAL_PROTEIN_IMPORT

PEX14 HAO1 HSD17B4

9.89e-0463443M27915
PathwayREACTOME_PEROXISOMAL_PROTEIN_IMPORT

PEX14 HAO1 HSD17B4

1.08e-0365443MM15628
PathwayREACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS

ATP1A1 ATP1A2 ATP1A3 ATP1A4

1.32e-03154444M39007
PathwayREACTOME_VIRAL_INFECTION_PATHWAYS

GTF2B BCAP31 TKFC PSMB4 ATP1A1 ATP1A2 ATP1A3 ATP1A4 AGRN

1.44e-03888449M48034
PathwayREACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT

PEX14 SLC25A17

1.57e-0319442MM15651
PathwayREACTOME_PROTEIN_LOCALIZATION

PEX14 HAO1 HSD17B4 SLC25A17

1.67e-03164444M27932
PathwayREACTOME_CLASS_I_PEROXISOMAL_MEMBRANE_PROTEIN_IMPORT

PEX14 SLC25A17

1.75e-0320442M27930
Pubmed

Multiple genes encode the human Na+,K+-ATPase catalytic subunit.

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.18e-1455953035563
Pubmed

The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

7.08e-1465953036582
Pubmed

Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction.

ATP1A1 ATP1A2 ATP1A3 AGRN

7.47e-12459419376779
Pubmed

Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.

ATP1A1 ATP1A2 ATP1A3 ATP1A4

7.47e-12459421849490
Pubmed

Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse.

ATP1A1 ATP1A2 ATP1A3 ATP1A4

2.60e-10759410837135
Pubmed

Molecular genetics of Na,K-ATPase.

ATP1A1 ATP1A2 ATP1A3 ATP1A4

2.60e-1075942158121
Pubmed

Biology, structure and mechanism of P-type ATPases.

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.36e-092959515071553
Pubmed

Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression.

ATP1A1 ATP1A2 ATP1A3

4.64e-0935938203495
Pubmed

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.

ATP1A1 ATP1A2 ATP1A3

4.64e-0935932822726
Pubmed

Na+/K+-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes.

ATP1A1 ATP1A2 ATP1A3

4.64e-09359330819023
Pubmed

Na,K-ATPase and the role of alpha isoforms in behavior.

ATP1A1 ATP1A2 ATP1A3

4.64e-09359318044013
Pubmed

Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase.

ATP1A1 ATP1A3 ATP1A4

4.64e-09359326373354
Pubmed

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.

ATP1A1 ATP1A2 ATP1A3

4.64e-09359326911348
Pubmed

Differential expression of Na+/K+-ATPase alpha-subunits in mouse hippocampal interneurones and pyramidal cells.

ATP1A1 ATP1A2 ATP1A3

4.64e-09359317947306
Pubmed

Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase.

ATP1A1 ATP1A2 ATP1A3

4.64e-09359325994790
Pubmed

Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.

ATP1A1 ATP1A2 ATP1A3

4.64e-09359319058785
Pubmed

Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.

ATP1A1 ATP1A2 ATP1A3

4.64e-09359328465228
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

FLNB BCAP31 CFL1 AHNAK BOD1L1 ACTN2 ATP1A1 ATP1A2 ATP1A3 PDE10A ATP12A HSD17B4 ATP1A4 RAI1 VAT1

1.22e-081442591535575683
Pubmed

Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.

ATP1A1 ATP1A2 ATP1A3

1.85e-08459321731499
Pubmed

The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.

ATP1A1 ATP1A2 ATP1A3

1.85e-08459312458206
Pubmed

Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1.

ATP1A1 ATP1A2 ATP1A3

1.85e-08459319751721
Pubmed

Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.

ATP1A1 ATP1A2 ATP1A3

1.85e-08459317446412
Pubmed

Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice.

ATP1A1 ATP1A2 ATP1A3

1.85e-08459317234593
Pubmed

Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.

ATP1A1 ATP1A3 ATP1A4

1.85e-0845932887455
Pubmed

Ouabain inhibits tubuloglomerular feedback in mutant mice with ouabain-sensitive alpha1 Na,K-ATPase.

ATP1A1 ATP1A2 ATP12A

4.63e-08559316870707
Pubmed

Transport and pharmacological properties of nine different human Na, K-ATPase isozymes.

ATP1A1 ATP1A2 ATP1A3

9.24e-08659310636900
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

FLNB BCAP31 EPPK1 CFL1 AHNAK PSMB4 CNDP2 CHD8 ATP1A1 PALS2 VAT1

9.96e-08807591130575818
Pubmed

Expression and distribution of Na, K-ATPase isoforms in the human uterus.

ATP1A1 ATP1A2 ATP1A3

1.62e-07759320065300
Pubmed

Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.

ATP1A1 ATP1A2 ATP1A3 ATP12A

1.98e-07305942842249
Pubmed

Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of Na,K-ATPase beta1-subunit.

ATP1A1 ATP1A2 ATP1A3

2.58e-07859319683723
Pubmed

Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.

ATP1A1 ATP1A2 ATP1A3

2.58e-0785932885848
Pubmed

Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.

ATP1A1 ATP1A2 ATP1A3

2.58e-07859323652595
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

TCAF1 EPPK1 CTCF AHNAK CHD8 ATP1A1 DDX41 RAI1

3.38e-0739459827248496
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

EPHB2 FLNB TCAF1 BCAP31 EPPK1 CFL1 AHNAK PSMB4 PEX14 ATP1A1 HSD17B4 VAT1 PMM2

3.79e-071367591332687490
Pubmed

The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.

ATP1A1 ATP1A2 ATP1A3

3.87e-07959315253893
Pubmed

Retinal pigment epithelial integrity is compromised in the developing albino mouse retina.

ATP1A1 ATP1A2 ATP1A3

1.01e-061259327097562
Pubmed

ZBTB20 is essential for cochlear maturation and hearing in mice.

ATP1A1 ATP1A2 ATP1A3 TECTA

1.26e-064759437279265
Pubmed

Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by Southern blot analysis of rat x mouse somatic cell hybrid clones.

ATP1A1 ATP1A2 ATP1A3

1.67e-06145931572638
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

FLNB TKFC CFL1 CNDP2 ATP1A1 ATP1A2 ATP1A3 HSD17B4 VAT1 PMM2

2.05e-06878591037223481
Pubmed

Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.

ATP1A1 ATP1A2

2.83e-06259215781423
Pubmed

Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.

NLGN4X NLGN4Y

2.83e-06259229106499
Pubmed

Agrin-signaling is necessary for the integration of newly generated neurons in the adult olfactory bulb.

ATP1A3 AGRN

2.83e-06259222423096
Pubmed

DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase.

ATP1A1 ATP1A2

2.83e-06259222258333
Pubmed

Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.

NLGN4X NLGN4Y

2.83e-06259226456829
Pubmed

Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.

NLGN4X NLGN4Y

2.83e-06259224104404
Pubmed

Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes.

ATP1A1 ATP1A2

2.83e-06259222739122
Pubmed

CTCF-dependent chromatin insulator is linked to epigenetic remodeling.

CTCF CHD8

2.83e-06259216949368
Pubmed

Alpha3Na+/K+-ATPase is a neuronal receptor for agrin.

ATP1A3 AGRN

2.83e-06259216630822
Pubmed

Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas.

ATP1A1 ATP1A3

2.83e-06259221498719
Pubmed

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart.

ATP1A1 ATP1A2

2.83e-06259210360172
Pubmed

Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons.

ATP1A1 ATP1A3

2.83e-06259223761886
Pubmed

Molecular cloning of the mouse ouabain-resistance gene.

ATP1A1 ATP1A2

2.83e-0625926324196
Pubmed

A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.

NLGN4X NLGN4Y

2.83e-06259232243781
Pubmed

Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive alpha1 Na+-K+-ATPase.

ATP1A1 ATP1A2

2.83e-06259219376809
Pubmed

A real-time PCR method to genotype mutant mouse models with altered affinity for cardiotonic steroids on the Na,K-ATPase.

ATP1A1 ATP1A2

2.83e-06259235446892
Pubmed

Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.

NLGN4X NLGN4Y

2.83e-06259222989184
Pubmed

Unusually rapid evolution of Neuroligin-4 in mice.

NLGN4X NLGN4Y

2.83e-06259218434543
Pubmed

New molecular determinants controlling the accessibility of ouabain to its binding site in human Na,K-ATPase alpha isoforms.

ATP1A1 ATP1A2

2.83e-06259214742675
Pubmed

Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases.

ATP1A1 ATP1A2

2.83e-06259211404365
Pubmed

Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.

ATP1A1 ATP1A2

2.83e-06259220952666
Pubmed

Interaction of the alpha subunit of Na,K-ATPase with cofilin.

CFL1 ATP1A1

2.83e-06259211139403
Pubmed

The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit.

ATP1A1 ATP1A3

2.83e-0625923030810
Pubmed

ATP1A2- and ATP1A3-associated early profound epileptic encephalopathy and polymicrogyria.

ATP1A2 ATP1A3

2.83e-06259233880529
Pubmed

Ouabain-Sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load.

ATP1A1 ATP1A2

2.83e-06259218667729
Pubmed

Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the α1 or α2 Na-K-ATPase ouabain-binding site.

ATP1A1 ATP1A2

2.83e-06259221632957
Pubmed

Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease.

ATP1A2 ATP1A3

2.83e-06259224356962
Pubmed

Genetic suppression of agrin reduces mania-like behavior in Na+ , K+ -ATPase α3 mutant mice.

ATP1A3 AGRN

2.83e-06259222520507
Pubmed

The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility.

ATP1A1 ATP1A2

2.83e-06259211507009
Pubmed

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.

NLGN4X NLGN4Y

2.83e-06259223183221
Pubmed

The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1.

ATP1A2 ATP1A4

2.83e-06259210555956
Pubmed

Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.

NLGN4X NLGN4Y

2.83e-06259224855039
Pubmed

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations.

ATP1A2 ATP1A3

2.83e-06259218957371
Pubmed

Expression of alpha isoforms of the Na,K-ATPase in human heart.

ATP1A1 ATP1A2

2.83e-0625928391840
Pubmed

All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.

ATP1A1 ATP1A3

2.83e-06259211546672
Pubmed

Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.

NLGN4X NLGN4Y

2.83e-06259237001827
Pubmed

Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.

NLGN4X NLGN4Y

2.83e-06259237080762
Pubmed

Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance.

ATP1A1 ATP1A3

2.83e-06259224391932
Pubmed

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction.

ACTN2 ATP1A1 ATP1A2 ATP1A3 PDE10A

2.99e-0613159528634551
Pubmed

PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes.

ATP1A1 ATP1A2 ATP1A3

3.10e-061759336230906
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

TCAF1 CTCF CFL1 PSMB4 CHD8 TUT1 ATP1A1 ATP1A2 ATP1A3 ATP1A4 DDX41

3.30e-061153591129845934
Pubmed

RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks.

ATP1A1 ATP1A2 ATP1A3

4.41e-061959320861386
Pubmed

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.

EPPK1 CFL1 ATP1A2 ATP1A3 ATP1A4 DDX41

4.87e-0625659635777956
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

FLNB GUCY1A1 NLGN4Y SAMD12 CNDP2 PEX14 BOD1L1 PDE10A PALS2 TECTA RAI1 PDZD2

6.27e-061489591228611215
Pubmed

Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling.

BCAP31 AHNAK ATP1A1 VAT1

7.86e-067459417255364
Pubmed

Analysis of the neuroligin 4Y gene in patients with autism.

NLGN4X NLGN4Y

8.48e-06359218628683
Pubmed

Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+,K+-ATPase-related neurologic disorders.

ATP1A2 ATP1A3

8.48e-06359233544780
Pubmed

Translationally controlled tumor protein interacts with the third cytoplasmic domain of Na,K-ATPase alpha subunit and inhibits the pump activity in HeLa cells.

ATP1A1 ATP1A2

8.48e-06359215383549
Pubmed

Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance.

ATP1A1 ATP1A2

8.48e-06359211557593
Pubmed

Purification of the human alpha2 Isoform of Na,K-ATPase expressed in Pichia pastoris. Stabilization by lipids and FXYD1.

ATP1A1 ATP1A2

8.48e-06359218052210
Pubmed

Isoform specificity of the Na/K-ATPase association and regulation by phospholemman.

ATP1A1 ATP1A2

8.48e-06359219638348
Pubmed

High glucose levels induce inhibition of Na,K-ATPase via stimulation of aldose reductase, formation of microtubules and formation of an acetylated tubulin/Na,K-ATPase complex.

ATP1A1 ATP1A2

8.48e-06359222565168
Pubmed

Simultaneously reduced NKCC1 and Na,K-ATPase expression in murine cochlear lateral wall contribute to conservation of endocochlear potential following a sensorineural hearing loss.

ATP1A1 ATP1A2

8.48e-06359221094218
Pubmed

Effect of resistance training on Na,K pump and Na+/H+ exchange protein densities in muscle from control and patients with type 2 diabetes.

ATP1A1 ATP1A2

8.48e-06359214685860
Pubmed

Na(+) pump alpha 2-isoform specifically couples to contractility in vascular smooth muscle: evidence from gene-targeted neonatal mice.

ATP1A1 ATP1A2

8.48e-06359214627611
Pubmed

Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.

ATP1A1 ATP1A3

8.48e-06359226988030
Pubmed

In situ localization of sodium-potassium ATPase mRNA in developing mouse lung epithelium.

ATP1A1 ATP1A2

8.48e-0635927573462
Pubmed

Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.

NLGN4X NLGN4Y

8.48e-06359232011705
Pubmed

Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.

ATP1A1 ATP1A3

8.48e-06359227836549
Pubmed

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart.

ATP1A1 ATP1A2

8.48e-06359215485817
Pubmed

Identification of ocular regulatory functions of core histone variant H3.2.

EPHB2 EPHA3

8.48e-06359236529279
InteractionATP4A interactions

BCAP31 AHNAK ATP1A1 ATP1A2 ATP1A3 VAT1

5.02e-07103586int:ATP4A
InteractionAGR2 interactions

FLNB BCAP31 EPPK1 CFL1 AHNAK PSMB4 CNDP2 CHD8 ATP1A1 PALS2 AGRN VAT1

1.14e-059345812int:AGR2
InteractionMAP1B interactions

EPPK1 CTCF CFL1 BOD1L1 ATP1A2 ATP1A3 ATP1A4 DDX41 AGRN

2.17e-05539589int:MAP1B
InteractionAPH1B interactions

ATP1A1 ATP1A3 PDE10A

2.90e-0521583int:APH1B
Cytoband11q12.2

TKFC AHNAK TUT1

1.78e-053959311q12.2
Cytoband1q23.2

ATP1A2 ATP1A4

9.40e-04355921q23.2
GeneFamilyATPase Na+/K+ transporting subunits

ATP1A1 ATP1A2 ATP1A3 ATP1A4

7.15e-1074041208
GeneFamilyCDC like kinases

CLK3 CLK4

2.86e-054402480
GeneFamilyPDZ domain containing

MPP4 AHNAK PALS2 PDZD2

3.47e-041524041220
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB2 EPHA3

4.27e-04144021095
GeneFamilySterile alpha motif domain containing

EPHB2 SAMD12 EPHA3

9.66e-0488403760
GeneFamilyCalcium voltage-gated channel subunits|Membrane associated guanylate kinases

MPP4 PALS2

1.50e-0326402904
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NLGN4X ACTN2 EYA1 ATP1A2 ATP1A3

4.07e-06180595c72f15763ba707189e29c85db533557f01c7fdb1
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

GUCY1A1 ATP1A2 PDE10A EPHA3 PDZD2

4.19e-0618159533cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLNB B4GALNT3 EYA1 PDE10A ATP12A

4.30e-061825953f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 FLNB B4GALNT3 EYA1 ATP1A1

5.17e-06189595e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellCOVID-19-Heart|COVID-19 / Disease (COVID-19 only), tissue and cell type

ACTN2 ATP1A2 PDE10A EPHA3 PDZD2

5.30e-06190595918ad5037881212008f9f69d5df5da91fd01422c
ToppCellHematolymphoid-Endothelial-NOSTRIN|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

AHNAK ACTN2 ATP1A2 EPHA3 PDZD2

6.80e-06200595032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCellHematolymphoid-Endothelial-NOSTRIN--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

AHNAK ACTN2 ATP1A2 EPHA3 PDZD2

6.80e-062005957fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCellHematolymphoid-Endothelial-NOSTRIN---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

AHNAK ACTN2 ATP1A2 EPHA3 PDZD2

6.80e-0620059568fce28690246895fd33354b30960ebcc31aa4cc
ToppCellHematolymphoid-Endothelial-NOSTRIN-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

AHNAK ACTN2 ATP1A2 EPHA3 PDZD2

6.80e-06200595376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCellHematolymphoid-Endothelial-NOSTRIN----L2-6|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

AHNAK ACTN2 ATP1A2 EPHA3 PDZD2

6.80e-06200595878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCellHematolymphoid-Endothelial|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

AHNAK ACTN2 ATP1A2 EPHA3 PDZD2

6.80e-062005957136936d05ab344a560cf159684c881063b5430d
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

B4GALNT3 EYA1 PDE10A ATP12A

6.17e-051615942d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellfacs-Liver-Non-hepatocytes-3m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB TKFC HAO1 HSD17B4

7.97e-05172594feaaf8ca7983d04a59ed0a7b3fb0e6d4b3a055f2
ToppCellfacs-Liver-Non-hepatocytes-3m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB TKFC HAO1 HSD17B4

7.97e-051725949adfb4a65669cc536343616637058d0a4728013f
ToppCellfacs-Liver-Non-hepatocytes-3m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB TKFC HAO1 HSD17B4

7.97e-051725948aed9c113f27d00401c272a3684495a4bc75bd0f
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

B4GALNT3 EYA1 PDE10A ATP12A

8.90e-05177594779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

B4GALNT3 EYA1 PDE10A ATP12A

8.90e-051775940f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SAMD12 B4GALNT3 ATP12A RAI1

9.29e-051795946e965e424eebef50f0202cff75f458be395cfca1
ToppCellPericytes-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

FLNB ACTN2 ATP1A2 PDE10A

9.70e-0518159435c470988a93381eefa300831aabb813fa1b90bd
ToppCellfacs-Marrow-T-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB AHNAK ATP1A1 ATP1A3

9.70e-051815947286700396676fdc41d9723979b8b408177aceb9
ToppCellRA-07._Pericyte|RA / Chamber and Cluster_Paper

GUCY1A1 PDE10A EPHA3 PDZD2

9.70e-051815948dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCellRA-07._Pericyte|World / Chamber and Cluster_Paper

GUCY1A1 PDE10A EPHA3 PDZD2

9.91e-051825942075efeae633550fb2eb026d0dfd741c8252482e
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

GUCY1A1 PDE10A EPHA3 PDZD2

9.91e-05182594e67f3234165199085c793915ebb1f9bbd845e933
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GUCY1A1 CFL1 LRRK1 EPHA3

9.91e-05182594fa16e194f04250149c82e86551270b244cbc8af4
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLIN4 GUCY1A1 ATP1A2 KLHDC8B

9.91e-05182594ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

SAMD12 B4GALNT3 EYA1 ATP12A

1.01e-04183594940cbe298e9c53b5622af09264586ed823d3141f
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLIN4 GUCY1A1 ATP1A2 KLHDC8B

1.03e-0418459494748f63947db79a6b4540e3090a63689fdd9452
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLIN4 GUCY1A1 ATP1A2 KLHDC8B

1.03e-04184594819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNB SAMD12 LRRK1 PDE10A

1.08e-041865942d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCelldroplet-Marrow-BM-1m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB AHNAK CNDP2 HSD17B4

1.10e-04187594028e7d6e1211e123879d2f353dc32fae1185dd8e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNB B4GALNT3 EYA1 ATP1A1

1.10e-04187594f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellRV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

ACTN2 B4GALNT3 EYA1 ATP1A2

1.10e-0418759478cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FLNB SAMD12 AGRN VAT1

1.12e-0418859459f276e23c8380bae57d7ecca3a8b83df4bc150b
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

FLNB SAMD12 B4GALNT3 EYA1

1.15e-0418959484d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 NLGN4Y SAMD12 ATP1A1

1.17e-04190594bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

ACTN2 B4GALNT3 ATP1A2 PDZD2

1.17e-04190594de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCelldroplet-Marrow-nan-21m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNB AHNAK CNDP2 HSD17B4

1.17e-041905946c6d3259e23ec90c08756f500ae8a7aff8b8a5b3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 NLGN4Y SAMD12 ATP1A1

1.17e-04190594b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNB SAMD12 LRRK1 PDE10A

1.17e-04190594aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

SAMD12 B4GALNT3 EYA1 ATP12A

1.17e-0419059451ca9ef4df3220487152fcf684147730637c7cc1
ToppCelldroplet-Kidney-nan-21m-Epithelial-Stroma____kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLIN4 GUCY1A1 ATP1A2 KLHDC8B

1.17e-04190594e04f47705851563515b6a66a2634cf7a574f7bda
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLIN4 GUCY1A1 ATP1A2 KLHDC8B

1.19e-041915948e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 NLGN4Y SAMD12 ATP1A1

1.19e-041915945a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 NLGN4Y SAMD12 ATP1A1

1.19e-0419159455ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLNB SAMD12 LRRK1 PDE10A

1.19e-041915944b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLIN4 GUCY1A1 ATP1A2 KLHDC8B

1.19e-0419159460bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 NLGN4Y SAMD12 ATP1A1

1.19e-041915942fa1b9e76a0ed2d2f0de74349e266cf4a5f51aad
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

SAMD12 ATP1A1 PDE10A PDZD2

1.22e-041925947e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCellNS-moderate-d_16-33-Epithelial-Secretory|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FLNB SAMD12 ATP12A AGRN

1.32e-0419659470384c1da9baed843f414cfd1403ddd586a2db07
ToppCell5'-Adult-Distal_Rectal-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNB B4GALNT3 ATP1A1 APOBR

1.34e-0419759482e83b4e4f54f9aa3a4a7bbf48b6dd603adeb69b
ToppCell5'-Adult-Distal_Rectal-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNB B4GALNT3 ATP1A1 APOBR

1.34e-041975948f894a4f0d34289f19d227788466b9fb4be15d54
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-mast_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

AHNAK HSD17B4 ATP1A4 VAT1

1.34e-0419759461f909737c5f630beffdd326c6844215643dbdde
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BCAP31 AHNAK ATP1A1 AGRN

1.34e-0419759438ddbfb6f6146fb9c27b2dade843a9a103e7991e
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLNB EYA1 PDE10A ATP12A

1.37e-04198594fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCellmetastatic_Brain-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

GUCY1A1 ATP1A2 AGRN KLHDC8B

1.37e-0419859486a4c8e859ce11a95875f8844963baeb1ba898ec
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Neuronal-Neurons|GW10 / Sample Type, Dataset, Time_group, and Cell type.

TCAF1 CFL1 ATP1A3 VAT1

1.40e-041995940c5a5fbb174a013be10961f0db65c65c797ab4af
ToppCellBiopsy_Other_PF-Epithelial-KRT5-/KRT17+|Biopsy_Other_PF / Sample group, Lineage and Cell type

EPHB2 EPPK1 B4GALNT3 AGRN

1.42e-04200594077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLNB EYA1 PDE10A ATP12A

1.42e-04200594b992eeddee38e6fe3564e9b1850f6b20b89bf47d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLNB CNDP2 DDX41 APOBR

1.42e-04200594851c57187db8bc91a393655bca5f13e787a723d4
Drugouabagenin

ATP1A1 ATP1A2 ATP1A3 ATP12A

1.23e-0811584CID000010497
Drug22,23-dihydrobufalin

ATP1A1 ATP1A2 ATP1A3

1.56e-075583CID000195392
Drug3-acetylstrophanthin

ATP1A1 ATP1A2 ATP1A3

1.56e-075583CID003082282
Drugthevetin A

ATP1A1 ATP1A2 ATP1A3

1.56e-075583CID000441873
DrugETH157

ATP1A1 ATP1A2 ATP1A3

3.12e-076583CID000563154
Drugdihydrodigitoxigenin

ATP1A1 ATP1A2 ATP1A3

5.45e-077583CID000107549
DrugA-32686

ATP1A1 ATP1A2 ATP1A3

4.41e-0613583CID000004951
DrugHDMA

ATP1A1 ATP1A2 ATP1A3

1.04e-0517583CID000131092
Drugacetylstrophanthidin

ATP1A1 ATP1A2 ATP1A3

1.25e-0518583CID000006062
DrugAC1L1F3Q

ATP1A1 ATP1A2 ATP1A3

1.25e-0518583CID000003068
DrugNSC 234205

ATP1A1 ATP1A2 ATP1A3

1.25e-0518583CID000010104
DrugNSC89595

ATP1A1 ATP1A2 ATP1A3 ATP12A

1.35e-0557584CID000002464
DrugCymarigenen

ATP1A1 ATP1A2 ATP1A3

1.73e-0520583CID000005303
DrugAC1NST54

ATP1A1 ATP1A2 ATP1A3

2.02e-0521583CID005315525
Drugcardenolide

ATP1A1 ATP1A2 ATP1A3

2.68e-0523583CID000016142
DrugAS701

ATP1A2 ATP1A3

3.81e-054582CID000133528
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

5.15e-137585DOID:0060178 (implicated_via_orthology)
Diseasenervous system disease (implicated_via_orthology)

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.93e-1112585DOID:863 (implicated_via_orthology)
Diseasecups of coffee per day measurement

CLK3 ATP1A1 ATP1A3 ATP1A4

1.16e-0640584EFO_0006782
DiseaseALTERNATING HEMIPLEGIA OF CHILDHOOD 1

ATP1A2 ATP1A3

3.80e-062582C3549447
Diseasealternating hemiplegia of childhood (is_implicated_in)

ATP1A2 ATP1A3

3.80e-062582DOID:0050635 (is_implicated_in)
Diseaseepilepsy (implicated_via_orthology)

ATP1A1 ATP1A2 ATP1A3 ATP12A ATP1A4

1.75e-05163585DOID:1826 (implicated_via_orthology)
DiseaseAlternating hemiplegia of childhood

ATP1A2 ATP1A3

2.27e-054582C0338488
Diseasealcohol use disorder (implicated_via_orthology)

CFL1 ATP1A1 ATP1A2 ATP1A3 ATP1A4

4.13e-05195585DOID:1574 (implicated_via_orthology)
Diseaseeye disease (implicated_via_orthology)

RP1L1 EYA1

5.67e-056582DOID:5614 (implicated_via_orthology)
Diseaseabdominal adipose tissue measurement

ATP1A1 ATP1A3 ATP1A4

1.57e-0453583EFO_0803316
Diseasecalcium measurement

FBXO3 CHD8 EYA1 ATP1A1 ATP1A3 ATP1A4 SLC25A17

2.25e-04628587EFO_0004838
Diseasehyperhomocysteinemia (biomarker_via_orthology)

ATP1A1 ATP1A2

2.47e-0412582DOID:9279 (biomarker_via_orthology)
DiseaseZellweger Spectrum

PEX14 HSD17B4

2.92e-0413582C3658299
DiseaseZellweger-Like Syndrome

PEX14 HSD17B4

2.92e-0413582C0751594
DiseaseAdrenoleukodystrophy, Neonatal

PEX14 HSD17B4

3.92e-0415582C0282525
DiseaseZellweger Syndrome

PEX14 HSD17B4

4.48e-0416582C0043459
Diseasemyeloid white cell count

FLNB GUCY1A1 CFL1 LRRK1 ATP1A1 ATP1A3 ATP1A4 VAT1

4.71e-04937588EFO_0007988
DiseaseAutism Spectrum Disorders

NLGN4X CHD8 RAI1

6.35e-0485583C1510586
Diseasehearing impairment

EYA1 HSD17B4 TECTA

9.60e-0498583C1384666
Diseasebone fracture

AHNAK SAMD12 B4GALNT3

1.41e-03112583EFO_0003931
DiseaseIntellectual Disability

CTCF CHD8 ATP1A1 RAI1 PMM2

1.85e-03447585C3714756
Diseasesensorineural hearing loss (is_implicated_in)

BCAP31 TECTA

1.93e-0333582DOID:10003 (is_implicated_in)
DiseaseChloracne

EPPK1 AHNAK

1.93e-0333582C0263454

Protein segments in the cluster

PeptideGeneStartEntry
VIGDQAEKVLGGAIA

CHD8

1591

Q9HCK8
EGKEILVGDVGQTVD

CFL1

51

P23528
GVKLVSIGAEEIVDG

ACTN2

111

P35609
PEGFQVVKVGANGEV

CTCF

161

P49711
VVKVGANGEVETLEQ

CTCF

166

P49711
EEVVAAAGQEGQVEG

B4GALNT3

591

Q6L9W6
TKVFQGVLELEGVEG

AGRN

1131

O00468
IVGNLGEGTFGKVVE

CLK3

306

P49761
TGVVKEGDQIVGATI

AHNAK

46

Q09666
VGVEEGLVNVGTGQK

RAI1

1376

Q7Z5J4
GAGVVVGKVRAVDAD

PCDHA9

586

Q9Y5H5
VLGVKFEGGVVIAAD

PSMB4

56

P28070
GQNKFEEVDVVERGG

HHIPL1

421

Q96JK4
GDVIVIGLEKDSGAQ

LRRK1

1926

Q38SD2
VVGDIVEVKGGDQIP

ATP12A

201

P54707
NAEEVVVGDLVEVKG

ATP1A1

181

P05023
MVGEIQDQGEAEVKG

FER1L4

1146

A9Z1Z3
AAVDGGKLDVGNAEV

BCAP31

161

P51572
VKIEQVIGAGEFGEV

EPHB2

621

P29323
AKGDVEEVQGPGVVG

FBXO3

336

Q9UK99
VGDIGVEVEDPQGKN

FLNB

386

O75369
TGKDLVVGFVAGVVN

SLC25A17

101

O43808
IEKGIAGQVARTGEV

PDE10A

326

Q9Y233
VTVAGFQPGGAVEKE

PDZD2

1166

O15018
YVVIGDGVEEEQGAK

EYA1

551

Q99502
AVEGKVEVFLDGGVR

HAO1

281

Q9UJM8
VEVFLDGGVRKGTDV

HAO1

286

Q9UJM8
AGDKLVEVNGVSVEG

MPP4

196

Q96JB8
VDKNVIEIGAGTGLV

METTL21EP

116

A6NDL7
GVEAVAIHGGKDQEE

DDX41

456

Q9UJV9
EAQGLVGVQVAEAEK

MAGEA13P

21

A6NCF6
VNQGEGLKFVDGIVD

NLGN4Y

371

Q8NFZ3
GLKFVDGIVDNEDGV

NLGN4Y

376

Q8NFZ3
VGDIIKEVNGHEVGN

PALS2

171

Q9NZW5
TGVIVENENITKEGG

BOD1L1

1391

Q8NFC6
EEVVVGDLVEVKGGD

ATP1A2

181

P50993
KGVGIISEGNETVED

ATP1A2

626

P50993
EAVVADVLDKGSGVV

HSD17B4

426

P51659
ISIDKVVGAGEFGEV

EPHA3

621

P29320
NAEEVVVGDLVEIKG

ATP1A3

171

P13637
QEKVDLAVVEVGIGG

FPGS

191

Q05932
VLGKQVLVVGGVDEV

KLHDC8B

76

Q8IXV7
IVDTLGEGAFGKVVE

CLK4

161

Q9HAZ1
VNQGEGLKFVDGIVD

NLGN4X

371

Q8N0W4
GLKFVDGIVDNEDGV

NLGN4X

376

Q8N0W4
IGVVGGSDFEKVQEQ

PMM2

41

O15305
VASVVDVAKGVVQGG

PLIN4

96

Q96Q06
FVKVQADVGTIGGTV

PARS2

241

Q7L3T8
EVGVKELQEFVAEGG

TCAF1

341

Q9Y4C2
AVAAGVVGGEIQEKL

EPPK1

2286

P58107
EAVAAGVVGGEIQEK

EPPK1

2821

P58107
GVVGGEIQEKLLSAE

EPPK1

2826

P58107
EEAVAAGVVGGEIQE

EPPK1

3351

P58107
EAVAAGVVGGEIQEK

EPPK1

3886

P58107
GVVGGEIQEKLLSAE

EPPK1

3891

P58107
AVAAGVVGGEIQEKL

EPPK1

4421

P58107
VEEAVAAGVVGGEIQ

EPPK1

4951

P58107
AEGIKLQIEGEGVES

SAMD12

21

Q8N8I0
EGQGVVAFGQTKDII

SLC25A44

156

Q96H78
QEEGEGVVDVKGQVR

PEX14

296

O75381
AEGAGKGEEVVVVEK

APOBR

241

Q0VD83
QEVVLGDLVEIKGGD

ATP1A4

191

Q13733
DVKQLGGSVELVDIG

CNDP2

51

Q96KP4
ILVADQEVKIGGIGA

TECTA

771

O75443
GLQEEGVQLEEVKEG

RP1L1

1366

Q8IWN7
QKEIGDIAGVADVTI

GTF2B

271

Q00403
LTQKAGEGEQVEVDG

TUT1

456

Q9H6E5
GVVIAVGEGVSDRKA

VAT1

116

Q99536
PEKADGVVEGIDVNG

UBXN7

396

O94888
GVGLEEIAKQVNVVA

TKFC

171

Q3LXA3
EEDENILGVVGGTLK

GUCY1A1

146

Q02108