Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of presynapse assembly

LRFN4 LRFN5 LRFN3

9.15e-0542433GO:1905606
GeneOntologyBiologicalProcesssynaptic membrane adhesion

LRFN4 LRFN5 LRFN3

9.15e-0542433GO:0099560
GeneOntologyBiologicalProcessregulation of presynapse organization

LRFN4 LRFN5 LRFN3

1.20e-0446433GO:0099174
DomainLRRNT

LINGO4 LRFN4 LGR6 LRFN5 LRFN3

2.04e-0698405IPR000372
DomainLRRNT

LINGO4 LRFN4 LGR6 LRFN5 LRFN3

2.04e-0698405SM00013
DomainLeu-rich_rpt_typical-subtyp

LINGO4 LRFN4 LGR6 LRFN5 LRFN3

3.63e-05177405IPR003591
DomainLRR_TYP

LINGO4 LRFN4 LGR6 LRFN5 LRFN3

3.63e-05177405SM00369
DomainCys-rich_flank_reg_C

LINGO4 LRFN4 LRFN5 LRFN3

4.04e-0590404IPR000483
DomainLRRCT

LINGO4 LRFN4 LRFN5 LRFN3

4.04e-0590404SM00082
DomainIg_I-set

LINGO4 LRFN4 LRFN5 OPCML LRFN3

5.09e-05190405IPR013098
DomainI-set

LINGO4 LRFN4 LRFN5 OPCML LRFN3

5.09e-05190405PF07679
DomainLRR_1

LINGO4 LRFN4 LGR6 LRFN5 LRFN3

9.97e-05219405PF00560
DomainIGc2

LINGO4 LRFN4 LRFN5 OPCML LRFN3

1.39e-04235405SM00408
DomainIg_sub2

LINGO4 LRFN4 LRFN5 OPCML LRFN3

1.39e-04235405IPR003598
DomainLeu-rich_rpt

LINGO4 LRFN4 LGR6 LRFN5 LRFN3

2.69e-04271405IPR001611
DomainLRR_8

LINGO4 LRFN4 LGR6 LRFN3

4.79e-04171404PF13855
Domain-

LINGO4 LRFN4 LGR6 LRFN5 LRFN3

5.84e-043214053.80.10.10
DomainL_dom-like

LINGO4 LRFN4 LGR6 LRFN5 LRFN3

6.44e-04328405IPR032675
DomainIG

LINGO4 LRFN4 LRFN5 OPCML LRFN3

1.95e-03421405SM00409
DomainIg_sub

LINGO4 LRFN4 LRFN5 OPCML LRFN3

1.95e-03421405IPR003599
DomainMFS_dom

SLC29A4 SLC2A7 SLCO2A1

2.94e-03134403IPR020846
DomainIG_LIKE

LINGO4 LRFN4 LRFN5 OPCML LRFN3

3.79e-03491405PS50835
DomainIg-like_dom

LINGO4 LRFN4 LRFN5 OPCML LRFN3

4.20e-03503405IPR007110
DomainFN3

LRFN4 LRFN5 LRFN3

8.81e-03199403PS50853
DomainLRR

LINGO4 LGR6 LRFN5

9.05e-03201403PS51450
DomainFN3_dom

LRFN4 LRFN5 LRFN3

1.01e-02209403IPR003961
Domain-

LINGO4 LRFN4 LRFN5 OPCML LRFN3

1.31e-026634052.60.40.10
DomainIg-like_fold

LINGO4 LRFN4 LRFN5 OPCML LRFN3

1.68e-02706405IPR013783
Pubmed

Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.

LRFN4 LRFN5 LRFN3

1.76e-09343320410109
Pubmed

Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins.

LRFN4 LRFN5 LRFN3

6.14e-08743316828986
Pubmed

Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.

LINGO4 LRFN4 LRFN5 LRFN3

9.14e-083443418848646
Pubmed

SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.

LRFN4 LRFN5 LRFN3

3.97e-062543327480238
Pubmed

Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth.

LRFN4 LRFN3

4.48e-06343218585462
Pubmed

The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules.

LRFN4 LRFN5

8.94e-06443221736948
Pubmed

A novel family of adhesion-like molecules that interacts with the NMDA receptor.

LRFN4 LRFN3

3.12e-05743216495444
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

LRFN4 LRFN5 OPCML LRFN3

4.86e-0516243425826454
Pubmed

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.

HELZ2 MED24

9.78e-051243212189208
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

MED24 RPAP1 SLC30A9 ESPL1 KIAA2013 SLC27A3 FANCA

1.44e-0494243731073040
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HELZ2 LIME1 PIGG RPAP1 ESPL1 KIAA2013 FANCA

3.80e-04110543735748872
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ALG3 PIGG CSGALNACT2 MRC2 KIAA2013 SLC27A3 FANCA

6.25e-04120143735696571
Pubmed

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors.

SLC30A9 KIAA2013 DMAC1 FANCA

1.00e-0335943435559673
Cytoband20q13.3

LIME1 RTEL1

1.61e-042043220q13.3
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LINGO4 LRFN4 LRFN5 OPCML LRFN3

6.26e-06161305593
GeneFamilySynaptotagmins

SYT15 SYT17

3.56e-0417302765
GeneFamilySolute carriers

SLC30A9 SLC29A4 SLC2A7 SLCO2A1 SLC27A3

4.41e-04395305752
GeneFamilyFibronectin type III domain containing

LRFN4 LRFN5 LRFN3

2.32e-03160303555
GeneFamilyG protein-coupled receptors, Class A orphans

LGR6 MRGPRE

7.39e-0378302262
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

TMEM207 SYT17 SLCO2A1 PRIMA1 MRGPRE

5.53e-071664356a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3|lymph-node_spleen / Manually curated celltypes from each tissue

LINGO4 LST1 MRC2 SLCO2A1 OPCML

9.19e-07184435479e60f76c191253e23699c9dd7ef7efc08c59ad
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH12 OPCML MRGPRE SLC27A3

1.88e-051644340853e75b60b2a78257b660910c3ee15b09c5f5b0
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

LINGO4 LST1 MRC2 PRIMA1

2.27e-05172434200b2e63313b110b8ca59ee5b72c02cc8ed907cd
ToppCell10x3'2.3-week_14-16-Lymphocytic_NK-T_NK-ILC_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LINGO4 CXCR5 LST1 SLCO2A1

2.71e-0518043427672ac6a02172a31851f18decb9acffa8f5a703
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LINGO4 CXCR5 LST1 SLCO2A1

2.71e-05180434ca7c316027e31559103b2cab1a2c0de993e42e95
ToppCell5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LINGO4 CXCR5 LST1 SLCO2A1

2.71e-05180434eb26ba86fba26899e54c448afc25382ddc853013
ToppCellT_cells-CD56_bright_CD16-_NK_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

LINGO4 LST1 MRC2 SLCO2A1

3.55e-05193434826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SYT17 SLCO2A1 OPCML FANCA

3.55e-05193434bbdfda6665941cfa1965418bb91ef9ff43b1326f
Diseasechronic obstructive pulmonary disease

MED24 TUT1 RPAP1 PRDM15 MRC2 PRIMA1

3.53e-04688416EFO_0000341
Diseaseosteonecrosis

LRFN5 DMAC1

5.54e-0425412EFO_0004259
Diseasecolorectal cancer, overall survival

LRFN5 UNC5CL

7.47e-0429412EFO_0000638, MONDO_0005575
DiseaseMalignant neoplasm of salivary gland

ESPL1 FANCA

1.80e-0345412C0220636
DiseaseSalivary Gland Neoplasms

ESPL1 FANCA

1.96e-0347412C0036095
Diseasealcohol dependence

LRFN5 SYT17 OPCML

2.10e-03183413MONDO_0007079
Diseaseovarian cancer (is_implicated_in)

OPCML FANCA

2.77e-0356412DOID:2394 (is_implicated_in)
Diseasepost-traumatic stress disorder

LGR6 LRFN5 OPCML

2.78e-03202413EFO_0001358
DiseaseHallux valgus

UNC5CL OPCML

3.17e-0360412HP_0001822
Diseasevenous thromboembolism

APCDD1 PRDM15 FRMD1 OPCML

3.74e-03460414EFO_0004286
Diseaseasparaginase hypersensitivity

LST1 LGR6

5.16e-0377412EFO_0004881
DiseaseCorneal astigmatism

SYT17 DMAC1

5.16e-0377412EFO_1002040
Diseasegastric carcinoma

UNC5CL OPCML

6.83e-0389412EFO_0000178
Diseasechildhood aggressive behaviour measurement

TMEM207 OPCML

6.83e-0389412EFO_0007663
Diseasenevus count, cutaneous melanoma

RTEL1 FANCA

7.13e-0391412EFO_0000389, EFO_0004632

Protein segments in the cluster

PeptideGeneStartEntry
HRLLKTCWSCRVLSG

DMAC1

41

Q96GE9
RRLLSIHITCGTIWL

CXCR5

161

P32302
LCRWHRTGESILSLL

ALG3

306

Q92685
GTHLRLRRCSCSSWL

EDN2

41

P20800
PLHCNCELLWLRRLS

LRFN5

241

Q96NI6
ELVRHSSLLCLLWRL

RDH12

236

Q96NR8
VLHLCALRSLRWQLL

SLC2A7

271

Q6PXP3
GLRALWLCAALCASR

LGR6

6

Q9HBX8
LLLHRCCQLWLLSLR

KCNK16

256

Q96T55
WPRHLLRCVLLLGCL

MRC2

11

Q9UBG0
LHCNCELVWLRRLAR

LRFN3

251

Q9BTN0
RHLCRTLWLVAAVLL

MRGPRE

171

Q86SM8
RALACLWLSGTLLAH

OPCML

326

Q14982
LLLAICLACRLLWRL

PORCN

31

Q9H237
TGCTWRSRHLLHLLR

FRMD1

311

Q8N878
RTHWLLLGLALLCSL

CSGALNACT2

11

Q8N6G5
LLELTLEHCRRFCWS

ESPL1

251

Q14674
SLEPVLLCRWRRHCQ

FANCA

1176

O15360
RHTWSLLLAALACLV

APCDD1

491

Q8J025
HLLLRCCPLWRSLLD

HELZ2

2611

Q9BYK8
TCDCRLLWLLRLRRH

LINGO4

361

Q6UY18
LLSACLCWLHRRVKR

LST1

26

O00453
CLLCTTLAWREHLRD

RTEL1

51

Q9NZ71
LLLLLLIGASCCLWR

SYT15

16

Q9BQS2
ELCLVQVGLLWHRCR

TDRD6

71

O60522
RISGLLLCRWTCRHC

SYT17

16

Q9BSW7
EWHCRRRVCLGLLAL

NKPD1

111

Q17RQ9
LPCRSTLTWGRLCHL

PRDM15

391

P57071
LVLRRGCCWSSLLLH

PRIMA1

6

Q86XR5
ECIGLCRALLSALHW

MED24

116

O75448
CRALLSALHWLLRCT

MED24

121

O75448
ACWRRLGLCHSRIFD

SPATA3

121

Q8NHX4
IDHSCIRWNSLCLGR

SLCO2A1

576

Q92959
LLHCLRSCGARALVL

SLC27A3

206

Q5K4L6
CVSCWDLRGSLLSLR

TUT1

501

Q9H6E5
LLAQCLRWHCPRRLL

UNC5CL

26

Q8IV45
LGSLWDSLRHCSLLC

RPAP1

841

Q9BWH6
HRCSWSSLCRLRLRC

SLC30A9

11

Q6PML9
DWRGTHLLACSCLRV

SLC29A4

411

Q7RTT9
LCLQCWLRRPRIDSH

TMEM207

71

Q6UWW9
ASPWLILACCRLLRS

PIGG

656

Q5H8A4
SSWARRLLCLLGLLL

KIAA2013

16

Q8IYS2
LHCNCELLWLRRLAR

LRFN4

236

Q6PJG9
LLSLWALCTACRRPE

LIME1

21

Q9H400