Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 GMEB2 ZNF658B TFAP2B TFDP1 BMI1 ZNF430 SP8 ZNF668 ZNF117 ZNF100 ZBTB32 ZNF644 ZNF432 SMARCA4 ZNF727 SP9 ZNF615 SUZ12

2.10e-06127113024GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 GMEB2 ZNF658B TFAP2B BMI1 ZNF430 SP8 ZNF668 ZNF117 ZNF100 ZBTB32 ZNF644 ZNF432 SMARCA4 ZNF727 SP9 ZNF615 SUZ12

5.04e-06124413023GO:0000978
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 GMEB2 ZNF658B TFAP2B TFDP1 BMI1 ZNF430 SP8 ZNF668 ZNF117 ZNF100 ZBTB32 ZNF644 ZNF432 SMARCA4 ZNF398 ZNF727 SP9 ZNF615 SUZ12

6.98e-06145913025GO:0000977
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 GMEB2 ZNF658B TFAP2B TFDP1 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZNF432 ZNF398 ZNF727 SP9 ZNF615

3.84e-05141213023GO:0000981
GeneOntologyMolecularFunctiondiphosphoinositol tetrakisphosphate kinase activity

IP6K3 IP6K1

1.26e-0431302GO:0052839
GeneOntologyMolecularFunctioninositol 5-diphosphate pentakisphosphate 5-kinase activity

IP6K3 IP6K1

1.26e-0431302GO:0052836
GeneOntologyMolecularFunctioninositol hexakisphosphate 3-kinase activity

IP6K3 IP6K1

2.50e-0441302GO:0052724
GeneOntologyMolecularFunctioninositol hexakisphosphate 1-kinase activity

IP6K3 IP6K1

2.50e-0441302GO:0052723
GeneOntologyMolecularFunctiondiphosphoinositol pentakisphosphate kinase activity

IP6K3 IP6K1

4.15e-0451302GO:0000829
GeneOntologyMolecularFunctioninositol hexakisphosphate kinase activity

IP6K3 IP6K1

4.15e-0451302GO:0000828
GeneOntologyMolecularFunctioninositol-1,3,4,5,6-pentakisphosphate kinase activity

IP6K3 IP6K1

4.15e-0451302GO:0000827
GeneOntologyMolecularFunctioninositol hexakisphosphate 5-kinase activity

IP6K3 IP6K1

4.15e-0451302GO:0000832
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

ATAD5 WRNIP1 INO80 FBH1 SMARCA4

1.46e-031271305GO:0008094
GeneOntologyMolecularFunctionhistone H3K14 acetyltransferase activity

KAT7 KAT6B

1.47e-0391302GO:0036408
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ATAD5 WRNIP1 INO80 FBH1 SMARCA4 DKC1 NIPBL

1.66e-032621307GO:0140097
GeneOntologyCellularComponentchromatin

BNC2 SP3 INO80 GMEB2 TFAP2B TFDP1 KAT7 BMI1 SP8 ATXN7L3 ZBTB46 ZBTB32 FBH1 FAM111A BAZ2A PRAMEF14 RNF20 SMARCA4 SP9 SUZ12 KAT6B TAF12 NIPBL SLX4

3.60e-05148013824GO:0000785
GeneOntologyCellularComponentintracellular protein-containing complex

LEO1 UBE4B CNTRL ZNFX1 KAT7 BMI1 ATXN7L3 FBXO24 FBH1 PRAMEF14 RNF20 TRAPPC10 ARIH1 KAT6B TAF12 DCAF4 SLX4

2.33e-0497213817GO:0140535
GeneOntologyCellularComponentfibrillar center

LEO1 EXOSC8 IP6K1 FAM111A SMARCA4 DKC1

6.00e-041561386GO:0001650
GeneOntologyCellularComponenttransferase complex

LEO1 UBE4B ZNFX1 KAT7 BMI1 ATXN7L3 FBXO24 FBH1 PRAMEF14 RNF20 UGT3A2 SUZ12 ARIH1 KAT6B TAF12 DCAF4

6.27e-0496313816GO:1990234
DomainNPIP

NPIPB15 NPIPB9 NPIPB3 NPIPB5 NPIPB2 NPIPB8 NPIPB13 NPIPB6

1.37e-14141318IPR009443
DomainZnf_C2H2-like

BNC2 SP3 ZNF136 RNF166 ZNF157 ZSCAN4 ZNF652 ZNF254 KAT7 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615 SUZ12

2.48e-1079613125IPR015880
DomainZnF_C2H2

BNC2 SP3 ZNF136 RNF166 ZNF157 ZSCAN4 ZNF652 ZNF254 KAT7 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615 SUZ12

3.39e-1080813125SM00355
DomainZnf_C2H2

BNC2 SP3 ZNF136 RNF166 ZNF157 ZSCAN4 ZNF652 ZNF254 KAT7 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615

1.68e-0980513124IPR007087
Domainzf-C2H2

BNC2 SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615

2.81e-0969313122PF00096
DomainZINC_FINGER_C2H2_2

BNC2 SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615 SUZ12

4.21e-0977513123PS50157
DomainZINC_FINGER_C2H2_1

BNC2 SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615 SUZ12

4.42e-0977713123PS00028
Domain-

SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615

1.06e-08679131213.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZNF644 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615

1.55e-0869413121IPR013087
DomainSp1_fam

SP3 SP8 SP9

3.90e-05101313IPR030450
DomainRibosomal_L44e

RPL36AL RPL36A

4.88e-0521312IPR000552
DomainRibosomal_L44

RPL36AL RPL36A

4.88e-0521312PF00935
DomainHECW_N

HECW1 HECW2

4.88e-0521312IPR032348
DomainRibosomal_L44e

RPL36AL RPL36A

4.88e-0521312PD002841
DomainRIBOSOMAL_L44E

RPL36AL RPL36A

4.88e-0521312PS01172
Domain-

RPL36AL RPL36A

4.88e-05213123.10.450.80
DomainHECW_N

HECW1 HECW2

4.88e-0521312PF16562
Domainzf-C2H2_6

ZNF136 ZNF157 ZNF652 ZNF668 ZNF117 ZNF100 ZFP64 ZNF432 ZNF727 ZNF615

7.50e-0531413110PF13912
DomainMOZ_SAS

KAT7 KAT6B

4.82e-0451312PF01853
DomainHAT_MYST-type

KAT7 KAT6B

4.82e-0451312IPR002717
DomainMYST_HAT

KAT7 KAT6B

4.82e-0451312PS51726
DomainKRAB

ZNF136 ZNF157 ZNF254 ZNF430 ZNF100 ZNF432 ZNF398 ZNF727 ZNF615

9.61e-043581319PS50805
DomainKRAB

ZNF136 ZNF157 ZNF254 ZNF430 ZNF100 ZNF432 ZNF398 ZNF727 ZNF615

9.61e-043581319PF01352
DomainIPK

IP6K3 IP6K1

1.00e-0371312PF03770
DomainIPK

IP6K3 IP6K1

1.00e-0371312IPR005522
DomainKRAB

ZNF136 ZNF157 ZNF254 ZNF430 ZNF100 ZNF432 ZNF398 ZNF727 ZNF615

1.19e-033691319SM00349
DomainKRAB

ZNF136 ZNF157 ZNF254 ZNF430 ZNF100 ZNF432 ZNF398 ZNF727 ZNF615

1.21e-033701319IPR001909
DomainRibosomal_zn-bd

RPL36AL RPL36A

1.70e-0391312IPR011332
Pubmed

The sequence and analysis of duplication-rich human chromosome 16.

NPIPB9 NPIPB11 NPIPB3 NPIPB2 NPIPB8 CACNA1H SLX4

1.06e-0790145715616553
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NPC1 IGIP ZNF652 CNTRL ZNF254 INO80 ANKRD50 SHROOM2 KAT7 KCNJ3 PRAMEF14 DIAPH1 TRAPPC10 MACF1 ADAM17 ASXL2 GFPT2 SLX4 SNX5

1.41e-0710841451911544199
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

RPL36A LEO1 ATAD5 INO80 POM121C THOC5 KAT7 ATXN7L3 ZNF668 BAZ2A ZNF644 ZFP64 RNF20 SMARCA4 DKC1 ASXL2 SUZ12 TAF12 NIPBL NOL8

4.73e-0712941452030804502
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ATAD5 WRNIP1 MCC INO80 POM121C TFDP1 KAT7 ATXN7L3 BAZ2A DIAPH1 SMARCA4 MACF1 TTC39A ADAM17 SUZ12 PDCL KAT6B TAF12

1.02e-0611161451831753913
Pubmed

Interaction network of human early embryonic transcription factors.

ZSCAN4 INO80 POM121C TFDP1 ZNF644 SMARCA4 ASXL2 TAF12 NIPBL SLX4

2.38e-063511451038297188
Pubmed

Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.

BAZ2A MACF1 CACNA1H SUZ12

4.72e-0627145419026994
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NPC1 LEO1 UBE4B ZNFX1 SHROOM2 ITGB3BP FBH1 COG1 NEMF NGEF SMARCA4 MACF1 TTC17 GFPT2 TAF12 NIPBL SLX4 SNX5

7.24e-0612851451835914814
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

BNC2 SP3 ZNF254 TFDP1 KAT7 ZNF668 ZBTB46 BAZ2A PLXNC1 ZNF644 ZFP64 ZNF398 KAT6B TAF12

7.86e-068081451420412781
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF136 ATAD5 EXOSC8 INO80 TFDP1 KAT7 BMI1 BAZ2A ZNF644 SMARCA4 SUZ12 NIPBL

1.00e-056081451236089195
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

RPL36A ATAD5 INO80 TFDP1 KAT7 BMI1 SMARCA4 DKC1 TTC17 SUZ12 NIPBL

1.58e-055331451130554943
Pubmed

Brahma-related gene 1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up-regulating Ras-related associated with diabetes in the pathophysiologic processes of aortic dissection.

RRAD SMARCA4

1.73e-052145226344687
Pubmed

Inositol hexakisphosphate kinases differentially regulate trafficking of vesicular glutamate transporters 1 and 2.

IP6K3 IP6K1

1.73e-052145235936490
Pubmed

ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20.

ZSCAN4 RNF20

1.73e-052145229477841
Pubmed

INO80 requires a polycomb subunit to regulate the establishment of poised chromatin in murine spermatocytes.

INO80 SUZ12

1.73e-052145235006254
Pubmed

Shedding of klotho by ADAMs in the kidney.

KL ADAM17

1.73e-052145226155844
Pubmed

A Common Variant of NGEF Is Associated with Abdominal Visceral Fat in Korean Men.

RGS6 NGEF

1.73e-052145226340433
Pubmed

Decreased ADAM17 expression in the lungs of α-Klotho reduced mouse.

KL ADAM17

1.73e-052145231951006
Pubmed

Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.

HECW1 BMI1 ZBTB32 ARIH1 DCAF4 SLX4

2.59e-05138145628786561
Pubmed

Identification and characterization of a novel inositol hexakisphosphate kinase.

IP6K3 IP6K1

5.16e-053145211502751
Pubmed

Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17.

PLA2R1 ADAM17

5.16e-053145238897568
Pubmed

Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer.

BMI1 SUZ12

5.16e-053145225243792
Pubmed

Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases.

FBH1 RNF20

5.16e-053145237230987
Pubmed

Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.

BMI1 SUZ12

5.16e-053145222843710
Pubmed

Divergent origins and concerted expansion of two segmental duplications on chromosome 16.

NPIPB3 NPIPB5

5.16e-053145211948212
Pubmed

Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein.

RPL36AL RPL36A

5.16e-05314523542712
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

INO80 KAT7 BMI1 BAZ2A SMARCA4 KAT6B

5.33e-05157145630186101
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UBE4B WDR7 PPM1E BAZ2A ZNF644 MACF1 CACNA1H ASXL2 SUZ12

5.63e-05407145912693553
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

RPL36AL RPL36A HECW1 DAPK2 KAT7 BMI1 HECW2 RNF20 SMARCA4 GFPT2 ARIH1 KAT6B

5.95e-057301451234857952
Pubmed

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

TFDP1 BMI1 SMARCA4 SUZ12

6.22e-0551145422770845
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

INO80 GMEB2 ANKRD50 ZNF644 MACF1

7.41e-05103145510574462
Pubmed

A protein interaction landscape of breast cancer.

RRAD THOC5 TFDP1 MTMR14 RNF20 COPS7B SMARCA4 DKC1 MACF1 SUZ12 SNX5

7.57e-056341451134591612
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

LEO1 ATAD5 WRNIP1 INO80 THOC5 KAT7 RNF20 DIAPH1 SMARCA4 DKC1 SUZ12 ARIH1 TAF12 NIPBL

9.31e-0510141451432416067
Pubmed

Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression.

BMI1 SUZ12

1.03e-044145218453536
Pubmed

Klotho is a substrate for alpha-, beta- and gamma-secretase.

KL ADAM17

1.03e-044145219737556
Pubmed

Constitutive expression of the brg1 gene requires GC-boxes near to the transcriptional start site.

SP3 SMARCA4

1.03e-044145221149256
Pubmed

Additional sex combs-like 2 is required for polycomb repressive complex 2 binding at select targets.

ASXL2 SUZ12

1.03e-044145224040135
Pubmed

Expression and relevance of the G protein-gated K+ channel in the mouse ventricle.

RGS6 KCNJ3

1.03e-044145229352184
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

LEO1 UBE4B WRNIP1 BAZ2A ZNF644 RNF20 SMARCA4 TRAPPC10 DKC1 SUZ12 KAT6B NIPBL

1.03e-047741451215302935
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF136 ZNF430 ZNF100 ZNF644 ZNF432 ZNF615

1.17e-04181145637372979
Pubmed

Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.

RRAD BAZ2A SMARCA4 ASXL2

1.43e-0463145417672918
Pubmed

Mammalian SP/KLF transcription factors: bring in the family.

SP3 SP8 SP9

1.53e-0425145315820306
Pubmed

Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication.

KAT7 KAT6B

1.71e-045145217182677
Pubmed

NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.

HECW1 HECW2

1.71e-045145214684739
Pubmed

RGS6/Gβ5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate.

RGS6 KCNJ3

1.71e-045145220884879
Pubmed

Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.

SP8 SP9

1.71e-045145215358670
Pubmed

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

RNF20 NIPBL

1.71e-045145218299561
Pubmed

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.

FBH1 SLX4

1.71e-045145223361013
Pubmed

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

BMI1 SUZ12

2.56e-046145223982173
Pubmed

Human transcription factor protein interaction networks.

RPL36AL RPL36A ATAD5 INO80 GMEB2 POM121C TFDP1 ATXN7L3 ZNF644 SMARCA4 SP9 ASXL2 GFPT2 TAF12 NIPBL SLX4

3.22e-0414291451635140242
Pubmed

ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

DIAPH1 MACF1

3.58e-047145220937854
Pubmed

TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein.

BMI1 SUZ12

3.58e-047145225470042
Pubmed

Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation.

LEO1 RNF20

3.58e-047145222252316
Pubmed

RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins.

RNF166 WRNIP1

3.58e-047145234837535
Pubmed

Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.

SMARCA4 SUZ12

3.58e-047145222668559
Pubmed

Regulation of the Polycomb protein RING1B ubiquitination by USP7.

BMI1 SUZ12

3.58e-047145220800574
Pubmed

Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9.

BMI1 SUZ12

3.58e-047145225391650
Pubmed

Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

IPO8 SMARCA4 SUZ12 NIPBL

4.13e-0483145420562864
Pubmed

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

BMI1 BAZ2A SMARCA4 SUZ12 NIPBL

4.28e-04150145528242625
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

ZNFX1 COG1 HECW2 ZNF398 ARHGAP20

4.69e-04153145510718198
Pubmed

Genome-wide population-based association study of extremely overweight young adults--the GOYA study.

TFAP2B RGS6

4.75e-048145221935397
Pubmed

A long noncoding RNA protects the heart from pathological hypertrophy.

SMARCA4 SUZ12

4.75e-048145225119045
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

RPL36AL RPL36A GMEB2 KAT7 BAZ2A DKC1 SUZ12

4.91e-04330145733301849
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

RPL36A EXOSC8 POM121C KAT7 BAZ2A NEMF DKC1

5.09e-04332145725693804
Pubmed

Tagging genes with cassette-exchange sites.

BNC2 WDR7 ZNF254 KAT7 MACF1 KAT6B SNX5

5.36e-04335145715741177
Pubmed

HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.

HECW1 UBE4B HECW2 ARIH1

5.61e-0490145435671810
Pubmed

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

ZSCAN4 INO80 KAT7 SMARCA4

5.85e-0491145420362542
Pubmed

Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning.

SP8 SP9

6.10e-049145217509151
Pubmed

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.

BMI1 SUZ12

6.10e-049145220956546
Pubmed

The dynamics of polycomb group proteins in early embryonic nervous system in mouse and human.

BMI1 SUZ12

6.10e-049145223727134
Pubmed

Mapping the Genetic Landscape of Human Cells.

RPL36A LEO1 WDR7 NEMF RNF20 ZNF511 ARIH1 NOL8

6.38e-04451145830033366
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

IPO8 NPIPB11 THOC5 TFDP1 ZNF668 FAM111A RNF20 ASXL2 GFPT2 NOL8

6.56e-046891451036543142
Pubmed

Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.

KL RGS6 PLXNC1 TPH2 GPR156

6.78e-04166145519906978
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

BMI1 HECW2 RNF20 ARIH1

6.88e-0495145429643511
Pubmed

CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.

ZNF644 SMARCA4

7.60e-0410145219061646
Pubmed

EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis.

SMARCA4 SUZ12

7.60e-0410145235210568
Pubmed

Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.

BMI1 SUZ12

7.60e-0410145216687444
Pubmed

The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells.

ZBTB46 ADAM17

7.60e-0410145233357409
Pubmed

Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.

IP6K3 IP6K1

9.26e-0411145230718399
Pubmed

NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling.

HECW1 HECW2

9.26e-0411145225555806
Pubmed

Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos.

BMI1 SMARCA4

9.26e-0411145224670652
Pubmed

Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells.

BMI1 SUZ12

9.26e-0411145221498568
Pubmed

Acetylation of HIV-1 integrase by p300 regulates viral integration.

KAT7 KAT6B

9.26e-0411145216096645
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

BAZ2A ZNF644 SMARCA4 DKC1

9.31e-04103145432744500
Pubmed

Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.

ATAD5 SUZ12

1.11e-0312145217632510
Pubmed

Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.

BMI1 SUZ12

1.11e-0312145220543829
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

INO80 TFDP1 BMI1 FBH1 ZNF644 DIAPH1 ASXL2 SUZ12

1.16e-03495145827705803
Pubmed

Transcription Factors Sp8 and Sp9 Regulate Medial Ganglionic Eminence-Derived Cortical Interneuron Migration.

SP8 SP9

1.31e-0313145231001083
Pubmed

Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.

SP8 SP9

1.31e-0313145231070778
Pubmed

Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons.

SP8 SP9

1.31e-0313145234014554
Pubmed

The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.

SMARCA4 NIPBL

1.31e-0313145215882967
Pubmed

PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification.

BMI1 SUZ12

1.31e-0313145229727681
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

IPO8 ATAD5 EXOSC8 ZNF668 NEMF SMARCA4 DKC1 MACF1 SUZ12 NOL8

1.36e-037591451035915203
Pubmed

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

BNC2 ATAD5 ZNF652 ZNFX1 GFPT2

1.49e-03198145520881960
Pubmed

NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.

HECW1 HECW2

1.52e-0314145227119228
Pubmed

The sperm-associated antigen 6 interactome and its role in spermatogenesis.

NPC1 C8orf48 NIPBL SNX5 NOL8

1.52e-03199145531146259
Pubmed

A census of human transcription factors: function, expression and evolution.

SP3 ZNF157 ZNF254 ZNFX1 GMEB2 TFAP2B TFDP1 THAP2 ZNF644 ZNF398 SP9

1.54e-039081451119274049
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

RPL36AL THOC5 RAB18 FAM111A BAZ2A SUZ12 NIPBL

1.73e-03410145726949251
Pubmed

Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18.

RAB18 COPS7B

1.75e-0315145237091236
Pubmed

Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency.

RPL36AL RPL36A

1.75e-0315145218400104
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SANBR INO80 GMEB2 ANKRD50 ANKH HECW2 ARHGAP20 KAT6B

1.76e-03529145814621295
InteractionCBX3 interactions

ZNF136 ATAD5 WRNIP1 TFDP1 BMI1 BAZ2A HECW2 ZNF644 DIAPH1 SMARCA4 MACF1 ASXL2 ZNF615 SUZ12 NIPBL SLX4 NOL8

1.39e-0664613417int:CBX3
Cytoband16p11.2

NPIPB7 NPIPB12 NPIPB11 ZNF668 NPIPB8 NPIPB13 NPIPB6

2.75e-06191145716p11.2
Cytoband16p12.2

OTOA NPIPB4 NPIPB3 NPIPB5

5.81e-0637145416p12.2
CytobandEnsembl 112 genes in cytogenetic band chr16p12

OTOA NPIPB7 NPIPB4 NPIPB3 NPIPB5 NPIPB6

1.92e-051721456chr16p12
CytobandEnsembl 112 genes in cytogenetic band chr16p11

NPIPB12 NPIPB9 NPIPB11 ZNF668 NPIPB8 NPIPB13

2.69e-042781456chr16p11
Cytoband12q21.1

THAP2 TPH2

1.15e-0316145212q21.1
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

BNC2 SP3 ZNF136 ZNF157 ZSCAN4 ZNF652 ZNF254 ZNF430 SP8 ZNF668 ZBTB46 ZNF117 ZNF100 ZBTB32 ZFP64 ZNF432 ZNF398 ZNF727 ZNF511 SP9 ZNF615 SUZ12

9.25e-12718932228
GeneFamilyZinc fingers C2H2-type|Sp transcription factors

SP3 SP8 SP9

1.08e-059933755
GeneFamilyZinc fingers C2HC-type|PHD finger proteins|Lysine acetyltransferases

KAT7 KAT6B

3.00e-031693266
GeneFamilyDNA helicases

INO80 FBH1

3.39e-03179321167
GeneFamilyLysine acetyltransferases|ATAC complex|SAGA complex|GCN5 related N-acetyltransferases

ATXN7L3 TAF12

3.39e-03179321059
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT7 KAT6B

3.39e-0317932486
ComputationalNeighborhood of PPM1D

PPM1E ANKRD50 KAT7 KAT6B

2.91e-0526754GCM_PPM1D
DiseaseC-reactive protein measurement

NPC1 BNC2 SP3 UBE4B NTSR1 CCDC168 ZBTB46 HSPA12A RGS6 ZNF644 SMARCA4 SP9 MACF1 DCAF4

7.66e-04120612814EFO_0004458
DiseaseMalignant neoplasm of breast

GFRAL PPM1E RRAD SHROOM2 THOC5 WDR53 ZNF668 ZNF644 ZFP64 ZNF432 MACF1 KAT6B NIPBL

8.13e-04107412813C0006142
Diseaserenal Wilms' tumor (is_implicated_in)

BMI1 SUZ12

8.21e-04101282DOID:5176 (is_implicated_in)
Diseaseurate measurement, bone density

UBE4B WDR7 MCC RGS6 PLXNC1 TPH2 DIAPH1 GFPT2 KAT6B

1.55e-036191289EFO_0003923, EFO_0004531
Diseasebeta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement

HECW1 ANKRD50

1.64e-03141282EFO_0004670, EFO_0006794
Diseasecoronary artery disease

NPC1 KCNH7 TTC41P ZNF652 INO80 ANKRD50 TFAP2B SP8 ZBTB46 ZNF100 SMARCA4 ZNF727 ARHGAP20

2.09e-03119412813EFO_0001645
Diseasefreckles

BNC2 HSPA12A

3.37e-03201282EFO_0003963
DiseaseHIV-1 infection, Susceptibility to viral and mycobacterial infections

GPR156 ADAM17

3.71e-03211282EFO_0000180, Orphanet_391311

Protein segments in the cluster

PeptideGeneStartEntry
TKSMNCLARKHSERE

ATAD5

1541

Q96QE3
AHELRLSCMERKKVQ

DCAF4

146

Q8WV16
DRLKAQLRHCMSKQA

CNTRL

2246

Q7Z7A1
NMRKKDAVLTKCFHV

RNF20

926

Q5VTR2
LKHLTIVSLASRMKC

COPS7B

96

Q9H9Q2
SCMLKHRLKLTNSEI

BRINP1

721

O60477
MSVKDFSKHNRTRCI

BNC2

686

Q6ZN30
RKKLLHSSQMLRAVS

BAZ2A

1101

Q9UIF9
CRQRPSMAKIKSHSQ

C1orf185

56

Q5T7R7
LIKCVSSRIKQFHMK

ERVV-2

481

B6SEH9
LLCSARKQSKAVTKM

ANKRD50

231

Q9ULJ7
SRNKHEIIRCLKAFM

DIAPH1

211

O60610
KRNGMCTDTHSLLSK

ETNPPL

481

Q8TBG4
VISEHTKKMCTRSLR

ATXN7L3

211

Q14CW9
LHTRQMKRTKCADID

ASXL2

256

Q76L83
HSRKNMLLATKQLCK

TFAP2B

351

Q92481
KVLASHKCQMDRSRE

GMEB2

296

Q9UKD1
EGLRSICMHTKKRVS

NPIPB3

116

Q92617
ICMHTKKRVSSFRGN

NPIPB3

121

Q92617
RKHSMLFIEASAKTC

RAB18

141

Q9NP72
MARSCREKTRHQKAT

ERAS

211

Q7Z444
QIDRHCLKMSKVAES

RGS6

271

P49758
AKLQDCMSRAVTRHK

EXOSC8

246

Q96B26
CMSRAVTRHKEVKKL

EXOSC8

251

Q96B26
NSRKLAHQCMKEVRR

INO80

306

Q9ULG1
EGLRSICMHTKKRVS

NPIPB12

116

F8W0I5
ICMHTKKRVSSFRGN

NPIPB12

121

F8W0I5
SHMEKLKTCSRANEL

KAT6B

966

Q8WYB5
RKMAFRAKSKSCHDL

RRAD

291

P55042
HSKRAVKKFVSCDVM

CAPN15

871

O75808
CHVINPSKKSRTRQM

ARIH1

161

Q9Y4X5
CTMKINLIHRRGDSK

C8orf48

126

Q96LL4
NNTCLKHMITKVRRD

HECW2

946

Q9P2P5
FCSMKRKDISQVLRS

OTOA

476

Q7RTW8
CLKYMKSQTILRRHM

KAT7

371

O95251
HRKMTLSLADRCSKT

LEO1

501

Q8WVC0
SHLRKIRTCTSIMEK

GPR82

226

Q96P67
MKCRKHLKSRRLVSA

NEMF

76

O60524
CHPFKAKTLMSRSRT

NTSR1

171

P30989
SKLQDLIHRSKMARC

MTMR14

111

Q8NCE2
RMHIDKRSHSCKDIT

KCNH7

976

Q9NS40
TCLKHMILKVRRDAR

HECW1

981

Q76N89
KILRTLMGHKANICS

KATNB1

96

Q9BVA0
CKRMKISHQRDGLTN

BMI1

231

P35226
HSKCMVKNVDSSREL

PLXNC1

531

O60486
RRKALSTCASHLMVV

OR4Q2

231

P0C623
MNRKDSKRKSHQECT

RASGRP4

1

Q8TDF6
SRQKGLRSICMHTKK

NPIPB8

131

E9PQR5
LRSICMHTKKRVSSF

NPIPB8

136

E9PQR5
KRAKCSTHKQRVIVM

NIPBL

1371

Q6KC79
EGLRSICMHTKKRVS

NPIPB5

116

A8MRT5
ICMHTKKRVSSFRGN

NPIPB5

121

A8MRT5
KERIRKLSMKASTCS

GLT8D1

226

Q68CQ7
CRKLRLHQMIELSSK

HSPA12A

246

O43301
KGLRSICMHTKKRVS

NPIPB7

116

O75200
ICMHTKKRVSSFRGN

NPIPB7

121

O75200
TTNLRMDCRKKHKDA

NOL8

1146

Q76FK4
EGLRSICMHTKKRVS

NPIPB4

116

C9JG80
ICMHTKKRVSSFRGN

NPIPB4

121

C9JG80
NCRSKRMLAIKRCKH

RPL36AL

76

Q969Q0
KKARHMRKCAQSTSA

IP6K3

231

Q96PC2
KGLRSICMHTKKRVS

NPIPB15

116

A6NHN6
ICMHTKKRVSSFRGN

NPIPB15

121

A6NHN6
CKLKETSSFRMRHLQ

MACF1

666

Q9UPN3
GVSLVRKKHMLSCFQ

MEI1

56

Q5TIA1
RKKHMLSCFQDALVR

MEI1

61

Q5TIA1
HKKAVLSPRNSRMVC

POM121C

231

A8CG34
SENMRKLRKTHDIPC

PPM1E

731

Q8WY54
HMKSCRRLLVDSKVS

NPC1

641

O15118
EGLRSICMHTKKRVS

NPIPB11

116

E5RHQ5
ICMHTKKRVSSFRGN

NPIPB11

121

E5RHQ5
HRVLSFKSDMKCVLQ

OSGIN2

381

Q9Y236
SCASHFLKREMQKTK

ITGB3BP

126

Q13352
TQMLKRAHDCRKTAE

MCC

496

P23508
MRRFKRKHLTAIDCQ

FBH1

1

Q8NFZ0
FRSTILHESKMLLKC

COG1

186

Q8WTW3
VKNICKTRMKRLDSS

GFPT2

231

O94808
KTRMKRLDSSACLHA

GFPT2

236

O94808
ESLCKIFQHMLHRKS

GFRAL

301

Q6UXV0
IVSLCNHLTRSLMKK

DAPK2

321

Q9UIK4
MSCKKQRSRKHSVNE

FAM111A

1

Q96PZ2
QRSRKHSVNEKCNMK

FAM111A

6

Q96PZ2
FVNSKRDRTKAVLCM

ANKH

76

Q9HCJ1
IHSCQTLQDRTEKMK

FBXO24

526

O75426
RCHKQQLSRMRSESK

IP6K1

186

Q92551
TIHCRKNRIVKMSSP

GPR156

71

Q8NFN8
RRMTDHSIKECQKSL

KL

306

Q9UEF7
MAKSKTKHRLCSQES

LAS2

1

Q8IYD9
HMKKRSVSGCNITIF

IGIP

6

A6NJ69
RRKELSCNLTTKMKE

CCDC168

1731

Q8NDH2
KSKKSPRSCMLHRTE

CCDC168

5386

Q8NDH2
NRFRVSCQKVITHKM

CACNA1H

1281

O95180
HKRLVMKDSAVNAIC

DKC1

296

O60832
RATKHKCRQLTKASL

SPACA9

191

Q96E40
SRQKGLRSICMHTKK

NPIPB6

131

E9PJ23
LRSICMHTKKRVSSF

NPIPB6

136

E9PJ23
NIRTRLSQKKTHMKC

MAP3K19

711

Q56UN5
KGLRSICMHTKKRVS

NPIPB9

131

F8W1W9
ICMHTKKRVSSFRGN

NPIPB9

136

F8W1W9
MCLRSHFKVAFTQRK

KLHL30-AS1

1

Q8NEE0
EGLRSICMHTKKRVS

NPIPB13

116

A6NJU9
ICMHTKKRVSSFRGN

NPIPB13

121

A6NJU9
MKDRKHIDVTNCNKR

NXPE1

286

Q8N323
RLIKKLSMTCRSHLD

PDCL

86

Q13371
ALGCRKAMKKFERHT

IL4I1

196

Q96RQ9
NAKHLEILFTMCRKV

IPO8

711

O15397
FSLVESRLKLCMKSH

ARHGAP20

1126

Q9P2F6
MKNLRKLVFSRCHHS

PRAMEF14

231

Q5SWL7
NCRSKRMLAIKRCKH

RPL36A

76

P83881
TKMKRRAVKIRHCNS

RPL37AP8

46

A6NKH3
CNKKVTLAKMRVHIS

RNF166

101

Q96A37
KACTTEAHKQRMALI

TAF12

141

Q16514
IRSQNLKECFRVHKM

NGEF

676

Q8N5V2
KLRATNHKVLLFCQM

SMARCA4

1091

P51532
MHRAKLQKSRSTVAL

SHROOM2

636

Q13796
TQLTKGCKVRDHMVT

SANBR

451

Q6NSI8
SCFKVFHSEKVLMKR

PLA2R1

676

Q13018
VCNKRFMRSDHLSKH

SP9

396

P0CG40
CNKRFMRSDHLSKHV

SP8

421

Q8IXZ3
LKSRTSHLKQCAVKM

SLX4

346

Q8IY92
MKNTCKLLVVADHRF

ADAM17

221

P78536
CTEKFKTSRDRKDHM

ZNF511

151

Q8NB15
CRKGFTMKSDLIVHQ

ZNF615

461

Q8N8J6
LRHFSMKVCEKVQRK

TFDP1

116

Q14186
TCSSNLIKHKRIHME

ZNF727

406

A8MUV8
EKSFCMLLHLTQHKR

ZNF100

211

Q8IYN0
SSSAMLICRRHQEIK

TRIM77

86

I1YAP6
KIFSMKKSLCQHRRT

ZNF157

421

P51786
AKRCFLSLLENMSKH

TTC30B

586

Q8N4P2
KAFTCITSVRRHMIK

ZNF136

231

P52737
CKETFSTMTLLRRHE

ZNF668

521

Q96K58
CSKRFMRSDHLAKHI

SP3

686

Q02447
THILVCRPKRTKASM

SUZ12

526

Q15022
ATRHREMLKRCKTQL

UBE4B

806

O95155
CSKSFMRKEHLLNHR

ZNF398

516

Q8TD17
KIKADQCHTMRKSGT

TTC41P

786

Q6P2S7
KRIMLECSQTKGHDR

TRBV24-1

36

A0A075B6N3
SCVKADKMTRSHKNV

SNX5

226

Q9Y5X3
KKVIRSLKRHSNICS

WDR53

126

Q7Z5U6
QTIQCHLMLKKGRRS

TTC17

1126

Q96AE7
RKISELDKCSHRVLM

TPH2

156

Q8IWU9
QEGLRSICMHTKKRV

NPIPB2

96

A6NJ64
LRKACSSKMDRQSVL

ZNFX1

191

Q9P2E3
SMCKKSFSHKTNLRS

ZSCAN4

371

Q8NAM6
TMHSALDCKQKKSRS

ZNF644

1226

Q9H582
VLARLSSRKMFCKKS

WRNIP1

451

Q96S55
DKSFCMLLHLTQHKR

ZNF430

211

Q9H8G1
AKRCFLSLLENMSKH

TTC30A

586

Q86WT1
CGKVFTMKSRLIEHQ

ZNF432

266

O94892
KTFCMLSHLTQHKRI

ZNF117

116

Q03924
SVCGKRFSLKHQMET

ZBTB32

376

Q9Y2Y4
YIRCKVRSRKHLTSM

TVP23B

171

Q9NYZ1
DFCTHIKSMKLKSRN

THAP2

81

Q9H0W7
KHKDKQRTGRCMVTT

TRAPPC10

906

P48553
CSHFLNRKDIMDSLK

UGT3A2

121

Q3SY77
ERRIQSCVHFMTLKK

THOC5

86

Q13769
SCVHFMTLKKLNRLA

THOC5

91

Q13769
SNMLKAHKEKCFRVT

ZNF652

481

Q9Y2D9
KRRTKDCNVISSKLM

UHRF1BP1

221

Q6BDS2
SLREKKCIMLASRHL

WDR7

546

Q9Y4E6
KEAQMLCQRHRRKSS

TTC39A

86

Q5SRH9
RKDKLKTHMRCHTGV

ZFP64

186

Q9NTW7
CTMKANLKSHIRIKH

ZFP64

451

Q9NTW7
KRVKLFCMLSHKTQH

ZNF254

186

O75437
CGKKFTRREHMKRHT

ZBTB46

451

Q86UZ6
TTLFNHMRTDKRGKC

ZNF658B

11

Q4V348
SHMVSAQIRCKLLKS

KCNJ3

221

P48549