Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7	6.14e-05	3	91	2	GO:0008389
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A7 CYP2J2	1.73e-04	24	91	3	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A7 CYP2J2	2.47e-04	27	91	3	GO:0008391
Domain	NPIP	NPIPB13 NPIPB3 NPIPB5	4.18e-05	14	93	3	IPR009443
Domain	POU	POU4F1 POU4F2 POU4F3	6.39e-05	16	93	3	SM00352
Domain	POU_2	POU4F1 POU4F2 POU4F3	6.39e-05	16	93	3	PS00465
Domain	POU_dom	POU4F1 POU4F2 POU4F3	6.39e-05	16	93	3	IPR000327
Domain	POU_3	POU4F1 POU4F2 POU4F3	6.39e-05	16	93	3	PS51179
Domain	Pou	POU4F1 POU4F2 POU4F3	6.39e-05	16	93	3	PF00157
Domain	POU_1	POU4F1 POU4F2 POU4F3	6.39e-05	16	93	3	PS00035
Domain	POU	POU4F1 POU4F2 POU4F3	7.73e-05	17	93	3	IPR013847
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7	1.46e-04	4	93	2	IPR008067
Domain	-	POU4F1 POU4F2 POU4F3	3.21e-04	27	93	3	1.10.260.40
Domain	Lambda_DNA-bd_dom	POU4F1 POU4F2 POU4F3	3.98e-04	29	93	3	IPR010982
Domain	Interfer-bind	CSF2RB IL20RB	1.08e-03	10	93	2	PF09294
Domain	Interferon/interleukin_rcp_dom	CSF2RB IL20RB	1.08e-03	10	93	2	IPR015373
Domain	PX	PIK3C2G NISCH SNX10	1.37e-03	44	93	3	SM00312
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A7 CYP2J2	1.46e-03	45	93	3	IPR002401
Domain	PX	PIK3C2G NISCH SNX10	1.87e-03	49	93	3	PF00787
Domain	PX	PIK3C2G NISCH SNX10	1.98e-03	50	93	3	PS50195
Domain	-	PIK3C2G NISCH SNX10	2.09e-03	51	93	3	3.30.1520.10
Domain	Phox	PIK3C2G NISCH SNX10	2.21e-03	52	93	3	IPR001683
Domain	Cyt_P450_CS	CYP2A6 CYP2A7 CYP2J2	2.34e-03	53	93	3	IPR017972
Domain	CYTOCHROME_P450	CYP2A6 CYP2A7 CYP2J2	2.88e-03	57	93	3	PS00086
Domain	-	CYP2A6 CYP2A7 CYP2J2	3.03e-03	58	93	3	1.10.630.10
Domain	p450	CYP2A6 CYP2A7 CYP2J2	3.03e-03	58	93	3	PF00067
Domain	Cyt_P450	CYP2A6 CYP2A7 CYP2J2	3.33e-03	60	93	3	IPR001128
Domain	RhoGEF	ARHGEF33 DNMBP FGD6	4.74e-03	68	93	3	SM00325
Domain	RhoGEF	ARHGEF33 DNMBP FGD6	5.14e-03	70	93	3	PF00621
Domain	DH_2	ARHGEF33 DNMBP FGD6	5.14e-03	70	93	3	PS50010
Domain	DH-domain	ARHGEF33 DNMBP FGD6	5.35e-03	71	93	3	IPR000219
Domain	-	ARHGEF33 DNMBP FGD6	5.35e-03	71	93	3	1.20.900.10
Domain	Calcineurin-like_PHP_ApaH	TMPPE PPP5C	8.52e-03	28	93	2	IPR004843
Domain	Metallophos	TMPPE PPP5C	8.52e-03	28	93	2	PF00149
Domain	FYVE	ZFYVE26 FGD6	9.13e-03	29	93	2	PF01363
Domain	FYVE	ZFYVE26 FGD6	9.13e-03	29	93	2	SM00064
Domain	Metallo-depent_PP-like	TMPPE PPP5C	9.75e-03	30	93	2	IPR029052
Domain	-	TMPPE PPP5C	9.75e-03	30	93	2	3.60.21.10
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	KMT2C AARS1 BCORL1 EPC1 TRPS1 MAML1 LARP1 MECOM PLK1 KDM6A RSU1 RBM20 CASZ1	8.13e-11	398	96	13	35016035
Pubmed	Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems.	POU4F1 POU4F2 POU4F3	2.04e-08	3	96	3	9598366
Pubmed	Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse.	POU4F1 POU4F2 POU4F3	2.04e-08	3	96	3	21935940
Pubmed	Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a.	POU4F1 POU4F2 POU4F3	2.04e-08	3	96	3	8290353
Pubmed	The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons.	POU4F1 POU4F2 POU4F3	2.04e-08	3	96	3	7623109
Pubmed	Systematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing.	POU4F1 POU4F2 POU4F3	2.04e-08	3	96	3	31286854
Pubmed	The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.	POU4F1 POU4F2 POU4F3	2.04e-08	3	96	3	7935408
Pubmed	Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes.	POU4F1 POU4F2 POU4F3	2.04e-08	3	96	3	8162704
Pubmed	miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning.	TNRC6A CNOT1 DDX6	2.04e-08	3	96	3	27009120
Pubmed	Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development.	POU4F1 POU4F2 POU4F3	8.14e-08	4	96	3	9256502
Pubmed	Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock-in allele.	POU4F1 POU4F2 POU4F3	8.14e-08	4	96	3	33135183
Pubmed	Morphologies of mouse retinal ganglion cells expressing transcription factors Brn3a, Brn3b, and Brn3c: analysis of wild type and mutant cells using genetically-directed sparse labeling.	POU4F1 POU4F2 POU4F3	8.14e-08	4	96	3	20826176
Pubmed	Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification.	POU4F1 POU4F2 POU4F3	8.14e-08	4	96	3	24116103
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MON2 SLF2 ZGRF1 BCORL1 TNRC6A MAML1 MECOM DNMBP DIS3 RBM20 KIF20B FAM83B	8.39e-08	588	96	12	38580884
Pubmed	Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development.	POU4F1 POU4F2 POU4F3	2.03e-07	5	96	3	8637595
Pubmed	The Wilms' tumor gene Wt1 is required for normal development of the retina.	POU4F1 POU4F2 POU4F3	4.05e-07	6	96	3	11889045
Pubmed	Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion.	POU4F1 POU4F2 POU4F3	4.05e-07	6	96	3	20533399
Pubmed	Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors.	POU4F1 POU4F2 POU4F3	4.05e-07	6	96	3	9630743
Pubmed	POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.	POU4F1 POU4F2 POU4F3	4.05e-07	6	96	3	8632990
Pubmed	Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.	POU4F1 POU4F2 POU4F3	4.05e-07	6	96	3	22262898
Pubmed	Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth.	POU4F1 POU4F2 POU4F3	4.05e-07	6	96	3	11807038
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NISCH EXOC6B DIP2C DNMBP CNOT1 DIS3	4.11e-07	102	96	6	10231032
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PALS1 TNRC6A NADK LARP1 PLK1 CSPP1 CNOT1 RSU1 DDX6 FAM83B	4.59e-07	446	96	10	24255178
Pubmed	Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells.	POU4F1 POU4F2 POU4F3	7.08e-07	7	96	3	9735355
Pubmed	A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.	TNRC6A CNOT1 DDX6	1.13e-06	8	96	3	24768540
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MON2 NUP155 PPP5C SEC24A UGGT1 TRPS1 TNRC6A EIF2AK4 HSD17B3 PLK1 CSPP1 CNOT1 KDM6A RBM20	1.14e-06	1049	96	14	27880917
Pubmed	RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.	POU4F1 POU4F2 POU4F3	2.41e-06	10	96	3	23805044
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZGRF1 BCORL1 TRPS1 TNRC6A MECOM CNOT1 RBM20 KIF20B SPDL1	2.48e-06	418	96	9	34709266
Pubmed	Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.	POU4F1 POU4F2 POU4F3	3.31e-06	11	96	3	8876243
Pubmed	Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons.	POU4F1 POU4F2 POU4F3	3.31e-06	11	96	3	8955272
Pubmed	The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells.	POU4F1 POU4F2 POU4F3	3.31e-06	11	96	3	28009286
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MON2 AARS1 GLB1 NISCH EXOC6B MAML1 NADK LARP1 OCRL FERMT2 PLK1 CSPP1 FGD6 CNOT1 DIS3	3.33e-06	1321	96	15	27173435
Pubmed	Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina.	POU4F1 POU4F2 POU4F3	4.40e-06	12	96	3	21771810
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	AARS1 CARMIL2 SLF2 SEC24A NADK LARP1 PLK1 DNMBP CSPP1 FGD6 DDX6 FAM83B	4.57e-06	861	96	12	36931259
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	KMT2C NUP155 SEC24A RAVER2 TNRC6A MAML1 CNOT1 DIS3 RBM20	5.10e-06	457	96	9	32344865
Pubmed	Brn3a and Brn3b knockout mice display unvaried retinal fine structure despite major morphological and numerical alterations of ganglion cells.	POU4F1 POU4F2	7.54e-06	2	96	2	27391320
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	7.54e-06	2	96	2	12325023
Pubmed	Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding.	POU4F1 POU4F2	7.54e-06	2	96	2	8537352
Pubmed	Brn3 transcription factors control terminal osteoclastogenesis.	POU4F1 POU4F2	7.54e-06	2	96	2	17668438
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	7.54e-06	2	96	2	16636685
Pubmed	Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.	CNOT1 DDX6	7.54e-06	2	96	2	25035296
Pubmed	Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor.	POU4F1 POU4F2	7.54e-06	2	96	2	8995448
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	7.54e-06	2	96	2	2322567
Pubmed	RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.	TNRC6A DDX6	7.54e-06	2	96	2	37427791
Pubmed	Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.	POU4F1 POU4F2	7.54e-06	2	96	2	8234287
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	7.54e-06	2	96	2	7864805
Pubmed	The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).	LARP1 EIF2AK4	7.54e-06	2	96	2	35863436
Pubmed	POU4F3 Is Necessary for Normal Merkel Cell Formation, whereas POU4F1 Is Dispensable.	POU4F1 POU4F3	7.54e-06	2	96	2	39009281
Pubmed	A single amino acid change converts an inhibitory transcription factor into an activator.	POU4F1 POU4F2	7.54e-06	2	96	2	8662774
Pubmed	Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus.	POU4F1 POU4F2	7.54e-06	2	96	2	10414983
Pubmed	Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid.	POU4F1 POU4F2	7.54e-06	2	96	2	7904822
Pubmed	NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons.	POU4F1 POU4F2	7.54e-06	2	96	2	9582431
Pubmed	Differential expression and subcellular localization of Copines in mouse retina.	POU4F1 POU4F2	7.54e-06	2	96	2	30866042
Pubmed	Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs.	POU4F1 POU4F3	7.54e-06	2	96	2	8248179
Pubmed	Integral bHLH factor regulation of cell cycle exit and RGC differentiation.	POU4F1 POU4F2 POU4F3	9.05e-06	15	96	3	29770538
Pubmed	Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.	ABCA13 POU4F1 POU4F2 POU4F3	1.05e-05	49	96	4	31609468
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	MON2 AARS1 RNF123 NUP155 PPP5C SEC24A UGGT1 LARP1 PLA2G4A FERMT2 DNMBP CNOT1 RSU1 DIS3 SPDL1	1.06e-05	1455	96	15	22863883
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PALS1 AARS1 NUP155 GLB1 NISCH DIAPH2 LARP1 EIF2AK4 DIS3 RBM20	1.29e-05	650	96	10	38777146
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KMT2C NUP155 TNRC6A MAML1 LARP1 EIF2AK4 DNMBP CNOT1 DIS3	1.63e-05	529	96	9	14621295
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	KMT2C TNRC6A EIF2AK4 CNOT1	2.21e-05	59	96	4	28813667
Pubmed	Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression.	POU4F1 POU4F2	2.26e-05	3	96	2	17145718
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7	2.26e-05	3	96	2	31645370
Pubmed	KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.	TNRC6A DDX6	2.26e-05	3	96	2	31400113
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	2.26e-05	3	96	2	11960914
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7	2.26e-05	3	96	2	3346244
Pubmed	Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.	CNOT1 DDX6	2.26e-05	3	96	2	24768538
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7	2.26e-05	3	96	2	2733794
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7	2.26e-05	3	96	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7	2.26e-05	3	96	2	8188299
Pubmed	No association between POU4F1, POU4F2, ISL1 polymorphisms and normal-tension glaucoma.	POU4F1 POU4F2	2.26e-05	3	96	2	32597291
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7	2.26e-05	3	96	2	8484736
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7	2.26e-05	3	96	2	8250953
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7	2.26e-05	3	96	2	2703500
Pubmed	Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors.	POU4F1 POU4F2	2.26e-05	3	96	2	15094508
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7	2.26e-05	3	96	2	1417950
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7	2.26e-05	3	96	2	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7	2.26e-05	3	96	2	32987105
Pubmed	Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.	POU4F1 POU4F2	2.26e-05	3	96	2	24736625
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7	2.26e-05	3	96	2	22217847
Pubmed	Pou4f2-GFP knock-in mouse line: A model for studying retinal ganglion cell development.	POU4F1 POU4F2	2.26e-05	3	96	2	27532212
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7	2.26e-05	3	96	2	2765478
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7	2.26e-05	3	96	2	2415518
Pubmed	POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.	POU4F1 POU4F2	2.26e-05	3	96	2	9448000
Pubmed	Divergent origins and concerted expansion of two segmental duplications on chromosome 16.	NPIPB3 NPIPB5	2.26e-05	3	96	2	11948212
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7	2.26e-05	3	96	2	22890016
Pubmed	CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.	CYP2A6 CYP2A7	2.26e-05	3	96	2	25710939
Pubmed	Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice.	POU4F1 POU4F2	2.26e-05	3	96	2	24608965
Pubmed	Distinct roles of transcription factors brn3a and brn3b in controlling the development, morphology, and function of retinal ganglion cells.	POU4F1 POU4F2	2.26e-05	3	96	2	19323995
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PALS1 NUP155 GLB1 TAMM41 NISCH OCRL FERMT2 FAM83B	2.26e-05	421	96	8	36976175
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	SEC24A TNRC6A MAML1 NADK OCRL FERMT2 PLK1 DNMBP CNOT1 RSU1 FAM83B	2.40e-05	853	96	11	28718761
Pubmed	Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.	POU4F1 POU4F2 POU4F3	3.02e-05	22	96	3	22326227
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	TAMM41 TNRC6A OCRL FERMT2 PLK1 CSPP1 CNOT1	3.22e-05	322	96	7	39098523
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	AARS1 TRPS1 KCTD20 LARP1 BMP8A APOL2 CNOT1	3.91e-05	332	96	7	37433992
Pubmed	Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.	POU4F1 POU4F2 POU4F3	4.49e-05	25	96	3	22411557
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7	4.51e-05	4	96	2	9408084
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7	4.51e-05	4	96	2	10490589
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7	4.51e-05	4	96	2	1970547
Pubmed	The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.	TNRC6A CNOT1	4.51e-05	4	96	2	23172285
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7	4.51e-05	4	96	2	7565685
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C BCORL1 EPC1 TRPS1 MAML1 MECOM KDM6A	5.55e-05	351	96	7	38297188
Interaction	SOX7 interactions	KMT2C BCORL1 TRPS1 MAML1 KDM6A RBM20 CASZ1	1.09e-07	82	94	7	int:SOX7
Interaction	GSC interactions	KMT2C BCORL1 TRPS1 MECOM KDM6A LRRC15	3.26e-06	87	94	6	int:GSC
Interaction	CEP128 interactions	PALS1 PCBP3 LZTS3 MECOM OCRL FERMT2 PLK1 CSPP1 FAM83B	1.03e-05	297	94	9	int:CEP128
Interaction	TBR1 interactions	KMT2C RNF123 TRPS1 MAML1 KDM6A SPDL1	1.48e-05	113	94	6	int:TBR1
Interaction	EGR2 interactions	KMT2C BCORL1 EPC1 TRPS1 MAML1 MECOM KDM6A	1.54e-05	171	94	7	int:EGR2
Interaction	FAM120C interactions	RNF123 NUP155 NISCH TNRC6A CSPP1 CNOT1 RBM20	3.14e-05	191	94	7	int:FAM120C
Interaction	KLF5 interactions	KMT2C EPC1 TRPS1 MAML1 LARP1 KDM6A RBM20	3.59e-05	195	94	7	int:KLF5
Interaction	CEP135 interactions	NUP155 LZTS3 TNRC6A PLK1 CSPP1 CNOT1 KIF20B FAM83B	4.06e-05	272	94	8	int:CEP135
Interaction	CYP2A7 interactions	CYP2A6 CYP2A7	6.44e-05	3	94	2	int:CYP2A7
Cytoband	16p12.2	NPIPB4 NPIPB3 NPIPB5 PLK1	1.12e-06	37	96	4	16p12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	NPIPB4 TNRC6A NPIPB3 NPIPB5 PLK1	3.23e-05	172	96	5	chr16p12
Cytoband	16p11.2	NPIPB13 NPIPB12 NPIPB11 TNRC6A	7.15e-04	191	96	4	16p11.2
GeneFamily	POU class homeoboxes and pseudogenes	POU4F1 POU4F2 POU4F3	5.58e-05	23	59	3	523
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A7 CYP2J2	2.01e-04	35	59	3	1001
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF33 DNMBP FGD6	1.31e-03	66	59	3	722
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	MON2 KMT2C TRPS1 TNRC6A EXOC6B DIP2C MECOM KDM6A	1.21e-08	199	96	8	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Mid-temporal_gyrus_(MTG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAVER2 DIAPH2 NPIPB3 GRM1 NPIPB5 DNAH6	2.43e-06	178	96	6	ad187db4c40b9078d54dd915c143e0172b2f47b8
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCBP3 PIK3C2G MECOM SLITRK3 CASZ1 FAM83B	2.68e-06	181	96	6	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KMT2C NPIPB4 DIAPH2 NPIPB3 NPIPB5 KDM6A	3.88e-06	193	96	6	779276e775cb2492e8dd36436295a536084a6415
Disease	adenoid cystic carcinoma (is_implicated_in)	KMT2C KDM6A	9.35e-05	5	91	2	DOID:0080202 (is_implicated_in)
Disease	phosphatidylcholine measurement	CBLIF GLB1 ZGRF1 TRPS1 OVCH1 FRMD3	2.53e-04	284	91	6	EFO_0010226
Disease	malaria	CHST15 NISCH EXOC6B DIP2C	2.86e-04	102	91	4	EFO_0001068
Disease	Cancer of Nasopharynx	CYP2A6 MECOM	3.34e-04	9	91	2	C0238301
Disease	Liver Diseases, Parasitic	CYP2A6 KMT2C	3.34e-04	9	91	2	C0023897
Disease	Nasopharyngeal Neoplasms	CYP2A6 MECOM	3.34e-04	9	91	2	C0027439
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	6.08e-04	12	91	2	EFO_0007794
Disease	response to carboplatin, methylcobalamin deficiency type cblE, response to antineoplastic agent	APOL2 FGD6	6.08e-04	12	91	2	GO_0097327, GO_0097328, MONDO_0009354
Disease	migraine disorder	DIP2C PLA2G4A POU4F3 RSU1 RBM20 CASZ1	8.45e-04	357	91	6	MONDO_0005277
Disease	neutrophil collagenase measurement	ABCA13 DNMBP	1.10e-03	16	91	2	EFO_0008248
Disease	response to haloperidol	EIF2AK4 NPVF	1.10e-03	16	91	2	GO_1905119
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	1.55e-03	19	91	2	EFO_0007872
Disease	otitis media (implicated_via_orthology)	NISCH MECOM	2.09e-03	22	91	2	DOID:10754 (implicated_via_orthology)
Disease	urinary albumin to creatinine ratio	CYP2A6 CYP2A7 RSU1 CASZ1	2.32e-03	179	91	4	EFO_0007778

Protein segments in the cluster

Peptide	Gene	Start	Entry
MPKQLIHIQPFSLDA	EPC1	96	Q9H2F5
PLSVQKFMNSHLQKP	DDX6	281	P26196
LNFLTKIHEMLQPGQ	APOL2	321	Q9BQE5
VMKHLPGPQQQAFQL	CYP2A6	226	P11509
QQLLKHSFINPQPKM	EIF2AK4	531	Q9P2K8
IMKFLPGPHQTLFSN	CYP2J2	236	P51589
PFKNNMSFVVLVPTH	SERPINF2	291	P08697
ILPLPSHSSVQMQNL	CASZ1	291	Q86V15
LEQNHSLKAMPLPLN	CARMIL2	661	Q6F5E8
MSHELVLATPQNLPK	BCORL1	991	Q5H9F3
ITHLMPPVKKSQQQQ	ARHGEF33	511	A8MVX0
LMTFTQHPNNLLKTI	ABCA13	2761	Q86UQ4
PLNQLLSMFTGPHKL	DNMBP	1106	Q6XZF7
KPLIQHPIDSQVAMS	DIAPH2	71	O60879
FLAMLLQNSPTKNHL	ENTPD3	271	O75355
NIKTPAFHPQRMIIS	NPIPB3	571	Q92617
LPFHPQLHPQQMIIS	NPIPB3	636	Q92617
SSLPFHPQLHPQQMI	NPIPB3	676	Q92617
SLPFHPQLHPQQMII	NPIPB3	761	Q92617
MNPSISPAFLHLNKA	RAVER2	381	Q9HCJ3
NLSHIPLAQQQLMKF	RAVER2	411	Q9HCJ3
KVAMSQPLFNQLRHP	RBM20	126	Q5T481
EPHPLMFQKLQDQIF	RGS10	121	O43665
PVKLNNLIHTLAQMS	PIK3C2G	1166	O75747
SLPFHPQLHSQQMII	NPIPB12	471	F8W0I5
LPFHPQLHPQQMIIS	NPIPB12	556	F8W0I5
SSLPFHPQLHPQQMI	NPIPB12	596	F8W0I5
TNKSQSPLMTHPQIL	MECOM	521	Q03112
KPALMAYLPQQLSHI	MAML1	536	Q92585
TLSHNNMIALKPILQ	POU4F1	316	Q01851
HLTSLPQQLPSQQLM	LARP1	581	Q6PKG0
MLNVLPQLLQHNKPS	KPNA7	326	A9QM74
LLPQQMQAFHSPKAL	KMT2C	4561	Q8NEZ4
PVVPKNFHSMQNLCP	LZTS3	166	O60299
SQPANLQFPHIMPLA	KCTD20	61	Q7Z5Y7
MKTDLLLVNHKPSPQ	KDM6A	866	O15550
GPQLTLFVPQHILMT	GLB1	596	P16278
KLPLQSEAPKMHTLQ	FAM83B	601	Q5T0W9
PKACVLQNPQTIMHI	NADK	76	O95544
KHMRQPSPIVPALQN	CSPP1	876	Q1MSJ5
QFTPLQPNKMAVKHP	KIF20B	1626	Q96Q89
SSLPFHPQLHPQQMI	NPIPB5	591	A8MRT5
SLPFHPQLHPQQMII	NPIPB5	676	A8MRT5
LPFHPQLHPQQMIIS	NPIPB5	761	A8MRT5
SSLPFHPQLHPQQMI	NPIPB5	801	A8MRT5
KQARLVLQPPSNMHE	EXOC6B	321	Q9Y2D4
LNPLKEMSNINHPDI	MON2	866	Q7Z3U7
SLPFHPQLHPQQMII	NPIPB4	681	C9JG80
LPFHPQLHPQQMIIS	NPIPB4	766	C9JG80
SSLPFHPQLHPQQMI	NPIPB4	806	C9JG80
PAPQNLSVLSTNMKH	IL20RB	36	Q6UXL0
QQHMLPPKKFVLLSA	NUP155	491	O75694
PHPDQLTKLHQLAMQ	PCBP3	236	P57721
LTKLHQLAMQQTPFP	PCBP3	241	P57721
SSLPFHPQLHPQQMI	NPIPB11	606	E5RHQ5
SLPFHPQLHPQQMII	NPIPB11	691	E5RHQ5
LPFHPQLHPQQMIIS	NPIPB11	776	E5RHQ5
SSLPFHPQLHPQQMI	NPIPB11	816	E5RHQ5
VHMNKASPPFPLISN	PALS1	171	Q8N3R9
SHSLNKQLIINMEPL	FRMD3	366	A2A2Y4
PMPSEHSLKQIFQAI	DNAH6	2236	Q9C0G6
HIKSSVNIQMAPPSL	CSF2RB	331	P32927
KFHNPMSIAQILPSL	CBLIF	261	P27352
CFILKMDHQNIPPLN	GKN2	81	Q86XP6
PQMPLQKLLFSATLT	DDX51	421	Q8N8A6
VMKHLPGPQQQAFKL	CYP2A7	226	P20853
QSLVHLMKPNAVPKA	BMP8A	351	Q7Z5Y6
HPQNIATTLPTVKMI	DIP2C	1061	Q9Y2E4
NILSFLKMQHLNPDP	FERMT2	491	Q96AC1
PPQHLQMLPLQLSTF	GRM1	1071	Q13255
KTVGQQMLSFPHLLQ	SLC31A1	121	O15431
NVGMLPNLLPSHFLN	HSD17B3	131	P37058
SLPFHPQLHPQQMII	NPIPB13	681	A6NJU9
MKNVSHNPLLLLTPQ	PLA2G4A	256	P47712
VLSHNKLTMVPPNIA	RSU1	46	Q15404
QVPHILCSPSMKNIN	HPS3	641	Q969F9
HISQLPPSVFMQLPQ	LRRC15	256	Q8TF66
KNQPLVYLMLTTHPS	SEC24A	931	O95486
NHIIQLNIINFPMKP	OVCH1	1016	Q7RTY7
TLSHNNMIALKPILQ	POU4F2	306	Q12837
HPNVKPMAYANTLLQ	PPP5C	481	P53041
NDNLIPMLPTNLFKA	SLITRK3	181	O94933
VVSLSPHKNLPVDMQ	SPDL1	511	Q96EA4
MQKPHLPLSQEKSAI	SLF2	436	Q8IX21
LSHNNMIALKPVLQA	POU4F3	236	Q15319
HQPFSQAVLSFLPKM	DIS3	441	Q9Y2L1
LVHNLNFKMPFPIDQ	SGSH	386	P51688
VPNQTLPQLNIMKHE	OCRL	401	Q01968
LPLKNQMKHPQQFSF	SLC36A3	271	Q495N2
LHMFSVIPNKFLPNS	CHST15	181	Q7LFX5
LMPIFLGNHPNSAII	CNOT1	506	A5YKK6
RMQPLHIQIKSPQES	TRPS1	1031	Q9UHF7
AHNPNMTHLKINLPV	ZWILCH	116	Q9H900
PAVNKMPHSFANLPL	NPVF	76	Q9HCQ7
MNQFKPIFLNTIDPS	AARS1	46	P49588
SLQKPCPSTLLQQHM	RNF123	1001	Q5XPI4
ALIHQMPPFISAQKH	FGD6	186	Q6ZV73
HLNVIKADFNPMPNR	NISCH	916	Q9Y2I1
QKPRPLQSNLLHQMC	MYCBPAP	756	Q8TBZ2
LPKTLQQQINHIMDP	TAMM41	251	Q96BW9
VQLPELPSKNLFFNM	SNX10	71	Q9Y5X0
KMALKEAHQPQTQPL	UBL4B	76	Q8N7F7
ALPPNKSKGINMNLH	ZGRF1	676	Q86YA3
LDTQQSIPMVKRPHN	ZFP2	61	Q6ZN57
TTLPLPTLFGNNHMK	ZFYVE26	2356	Q68DK2
QPLHQPAMKSFLDNV	TNRC6A	1476	Q8NDV7
PNNMIHQVPIKSLPQ	UGGT1	1456	Q9NYU2
NQITNHKPLPRATMA	VWA5B1	661	Q5TIE3
PKHINPVAASLIQKM	PLK1	271	P53350
PIHQLPASMNNLKIV	TMPPE	196	Q6ZT21
IFKLMIPNITQYSPH	LDHAL6A	116	Q6ZMR3