Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	5.76e-05	2	152	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	5.76e-05	2	152	2	GO:0047783
GeneOntologyMolecularFunction	phospholipid binding	AGAP5 APOA4 GAB2 RPS6KC1 RASA4 TLN1 SVIL SYT14 CLN6 RASA4B AGAP7P AGAP4 SNX2	2.94e-04	548	152	13	GO:0005543
MousePheno	abnormal circulating alkaline phosphatase level	TANC2 USP53 AGAP5 KATNAL2 BAZ2B SGSH LMTK2 LBR PHKB FAM120A AKAP9 COG6 PKD1 SERPING1 KIF3C AGAP7P AGAP4 ELMOD1	1.47e-05	639	125	18	MP:0000202
MousePheno	increased circulating alkaline phosphatase level	TANC2 USP53 AGAP5 KATNAL2 BAZ2B SGSH LMTK2 PHKB FAM120A AKAP9 COG6 KIF3C AGAP7P AGAP4 ELMOD1	7.03e-05	526	125	15	MP:0002968
MousePheno	abnormal ductus venosus valve morphology	DMXL2 CRIM1 COG6 SETD5 EXOC3L2	7.34e-05	49	125	5	MP:0013877
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	7.93e-05	2	125	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	7.93e-05	2	125	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	7.93e-05	2	125	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	7.93e-05	2	125	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	7.93e-05	2	125	2	MP:0011546
MousePheno	disproportionate dwarf	ERCC2 TRPS1 GGT1 TG PKD1	1.52e-04	57	125	5	MP:0002427
MousePheno	abnormal ductus venosus morphology	DMXL2 CRIM1 COG6 SETD5 EXOC3L2	1.65e-04	58	125	5	MP:0013873
Domain	PH_dom-like	DOK1 AGAP5 FRS2 PTPN21 GAB2 SPTBN5 RASA4 NBEAL2 TLN1 GAB3 RASA4B AGAP7P ARHGAP20 AGAP4	7.63e-06	426	148	14	IPR011993
Domain	ANK	TANC2 AGAP5 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP7P AGAP4	3.23e-05	251	148	10	SM00248
Domain	ANK_REPEAT	TANC2 AGAP5 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP7P AGAP4	3.45e-05	253	148	10	PS50088
Domain	Ankyrin_rpt-contain_dom	TANC2 AGAP5 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP7P AGAP4	3.57e-05	254	148	10	IPR020683
Domain	ANK_REP_REGION	TANC2 AGAP5 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP7P AGAP4	3.57e-05	254	148	10	PS50297
Domain	Ankyrin_rpt	TANC2 AGAP5 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP7P AGAP4	4.64e-05	262	148	10	IPR002110
Domain	Ank_2	TANC2 AGAP5 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP4	5.52e-05	215	148	9	PF12796
Domain	ARM-like	STK36 CLASP1 RANBP6 HUWE1 TRIP12 NALF1 MROH6 AP1B1 NBEAL2 TANGO6	5.97e-05	270	148	10	IPR011989
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	6.24e-05	2	148	2	IPR002399
Domain	-	DOK1 AGAP5 FRS2 PTPN21 GAB2 SPTBN5 RASA4 TLN1 GAB3 RASA4B ARHGAP20 AGAP4	6.76e-05	391	148	12	2.30.29.30
Domain	PH	DOK1 AGAP5 GAB2 SPTBN5 RASA4 GAB3 RASA4B AGAP7P ARHGAP20 AGAP4	7.62e-05	278	148	10	SM00233
Domain	PH_DOMAIN	DOK1 AGAP5 GAB2 SPTBN5 RASA4 GAB3 RASA4B AGAP7P ARHGAP20 AGAP4	7.85e-05	279	148	10	PS50003
Domain	PH_domain	DOK1 AGAP5 GAB2 SPTBN5 RASA4 GAB3 RASA4B AGAP7P ARHGAP20 AGAP4	8.08e-05	280	148	10	IPR001849
Domain	Ank	TANC2 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP7P AGAP4	8.67e-05	228	148	9	PF00023
Domain	-	TANC2 AGAP5 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP4	1.64e-04	248	148	9	1.25.40.20
Domain	IRS	DOK1 FRS2 TLN1	1.66e-04	14	148	3	PF02174
Domain	IRS_PTB	DOK1 FRS2 TLN1	1.66e-04	14	148	3	IPR002404
Domain	-	PKHD1L1 B4GALNT3	1.86e-04	3	148	2	3.90.182.10
Domain	PA14	PKHD1L1 B4GALNT3	1.86e-04	3	148	2	SM00758
Domain	PA14	PKHD1L1 B4GALNT3	1.86e-04	3	148	2	PF07691
Domain	PA14_dom	PKHD1L1 B4GALNT3	1.86e-04	3	148	2	IPR011658
Domain	-	RASA4 RASA4B	1.86e-04	3	148	2	4.10.1130.10
Domain	PH	DOK1 GAB2 SPTBN5 RASA4 GAB3 RASA4B AGAP7P AGAP4	4.89e-04	229	148	8	PF00169
Domain	ArfGap	AGAP5 AGAP7P AGAP4	1.53e-03	29	148	3	SM00105
Domain	ARFGAP	AGAP5 AGAP7P AGAP4	1.53e-03	29	148	3	PS50115
Domain	ArfGap	AGAP5 AGAP7P AGAP4	1.53e-03	29	148	3	PF01412
Domain	ArfGAP	AGAP5 AGAP7P AGAP4	1.53e-03	29	148	3	IPR001164
Domain	ARM-type_fold	STK36 CLASP1 RANBP6 HUWE1 TRIP12 MROH6 AP1B1 NBEAL2 TANGO6	1.55e-03	339	148	9	IPR016024
Domain	-	STK36 CLASP1 RANBP6 TRIP12 MROH6 AP1B1 TANGO6	1.98e-03	222	148	7	1.25.10.10
Domain	Cadherin	PCDHA6 RET PCDH17 CELSR2 PCDH8	2.06e-03	113	148	5	PF00028
Domain	CADHERIN_2	PCDHA6 RET PCDH17 CELSR2 PCDH8	2.15e-03	114	148	5	PS50268
Domain	-	PCDHA6 RET PCDH17 CELSR2 PCDH8	2.15e-03	114	148	5	2.60.40.60
Domain	BTK	RASA4 RASA4B	2.16e-03	9	148	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	2.16e-03	9	148	2	IPR001562
Domain	BTK	RASA4 RASA4B	2.16e-03	9	148	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	2.16e-03	9	148	2	PS51113
Domain	CA	PCDHA6 RET PCDH17 CELSR2 PCDH8	2.23e-03	115	148	5	SM00112
Domain	Cadherin-like	PCDHA6 RET PCDH17 CELSR2 PCDH8	2.31e-03	116	148	5	IPR015919
Domain	GPS	ADGRV1 CELSR2 PKD1	2.44e-03	34	148	3	SM00303
Domain	Cadherin	PCDHA6 RET PCDH17 CELSR2 PCDH8	2.49e-03	118	148	5	IPR002126
Domain	GPS	ADGRV1 CELSR2 PKD1	2.65e-03	35	148	3	PF01825
Domain	GPS	ADGRV1 CELSR2 PKD1	2.87e-03	36	148	3	PS50221
Domain	GPS	ADGRV1 CELSR2 PKD1	3.11e-03	37	148	3	IPR000203
Domain	PTBI	DOK1 FRS2	3.27e-03	11	148	2	SM00310
Domain	IRS_PTB	DOK1 FRS2	3.91e-03	12	148	2	PS51064
Domain	WWE	HUWE1 TRIP12	3.91e-03	12	148	2	PF02825
Domain	WWE-dom	HUWE1 TRIP12	3.91e-03	12	148	2	IPR004170
Domain	WWE	HUWE1 TRIP12	3.91e-03	12	148	2	PS50918
Domain	TTL	TTLL4 TTLL10	4.59e-03	13	148	2	PS51221
Domain	TTL/TTLL_fam	TTLL4 TTLL10	4.59e-03	13	148	2	IPR004344
Domain	6-hairpin_glycosidase-like	SPATA20 PHKB	4.59e-03	13	148	2	IPR008928
Domain	TTL	TTLL4 TTLL10	4.59e-03	13	148	2	PF03133
Domain	RasGAP	RASA4 RASA4B	5.33e-03	14	148	2	SM00323
Domain	RasGAP_CS	RASA4 RASA4B	5.33e-03	14	148	2	IPR023152
Domain	RasGAP	RASA4 RASA4B	6.12e-03	15	148	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	6.12e-03	15	148	2	PS00509
Domain	Galectin_CRD	LGALS12 LGALS7	6.12e-03	15	148	2	IPR001079
Domain	Gal-bind_lectin	LGALS12 LGALS7	6.12e-03	15	148	2	PF00337
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	6.12e-03	15	148	2	PS50018
Domain	Gal-bind_lectin	LGALS12 LGALS7	6.12e-03	15	148	2	SM00908
Domain	GALECTIN	LGALS12 LGALS7	6.12e-03	15	148	2	PS51304
Domain	GLECT	LGALS12 LGALS7	6.12e-03	15	148	2	SM00276
Domain	HEAT	STK36 CLASP1 RANBP6	6.50e-03	48	148	3	PF02985
Domain	-	LGALS12 ADGRV1 LGALS7 CELSR2	6.90e-03	95	148	4	2.60.120.200
Domain	-	RASA4 RASA4B	6.96e-03	16	148	2	1.10.506.10
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 STK36 CRYBG2 ERCC2 LMTK2 SPATA20 SLC10A3 ANKLE1 HUWE1 PCNX2 CDR2L MST1R INTS5 HEG1 KMT2D CELSR2 ZBED4 MROH6 SETD5 NBEAL2 TTLL4 TLN1 PKD1 NPRL3	1.52e-10	1105	155	24	35748872
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TANC2 DLGAP2 DMXL2 CLASP1 WDR7 SPTAN1 SPATA20 HUWE1 SHISA7 CEP170 FAM120A AKAP9 CELSR2 AP1B1 PTPRN2 SVIL PPP1R9B LAMTOR1 PCDH8	6.63e-08	963	155	19	28671696
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP5 DTNBP1 AGAP7P AGAP4	2.63e-07	13	155	4	27713690
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TANC2 USP53 CLASP1 SPTAN1 LMTK2 GIGYF1 LBR PTPN21 TRIP12 ENKD1 GAB2 CDR2L CEP170 AKAP9 SVIL CEP152 SNX2	3.38e-07	861	155	17	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 PLIN4 STK36 DMXL2 BAZ2B GRAMD1A CEP170 SHROOM4 FAM120A AARS2 EEPD1 CEP152 TANGO6	3.66e-07	493	155	13	15368895
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLGAP2 AGAP5 DMXL2 WDR7 SPTAN1 SHISA7 AP1B1 PPP1R9B AGAP7P AGAP4	5.92e-07	281	155	10	28706196
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	UBQLNL BAZ2B ZC3H13 FRS2 HUWE1 TRIP12 CXXC1 PCDH17 RPS6KC1 ZBED4 PTPRN2 TLN1 PKD1 EEF1AKMT1 ARHGAP20	1.17e-06	736	155	15	29676528
Pubmed	Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice.	PNMT CYP11B1 CYP11B2	1.72e-06	6	155	3	22580128
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	DOK1 STK36 PLB1 FRS2 HUWE1 ANKRD50 GABPB2 PARD6A ASB9 LNX1 CCDC33	2.54e-06	410	155	11	25814554
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	TANC2 ERCC2 CLASP1 BMP2K GIGYF1 ANKRD50 DTNBP1 ENKD1 GAB2 CLASRP LGALS7 CEP170 MROH6 AP1B1 TTLL4 LTV1 TRAK2	4.26e-06	1038	155	17	26673895
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	SGSH SPTAN1 CEP170 FAM120A AKAP9 AARS2 SVIL	6.81e-06	156	155	7	29961565
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP7P AGAP4	7.15e-06	9	155	3	12640130
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP7P AGAP4	1.02e-05	10	155	3	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP7P AGAP4	1.40e-05	11	155	3	15381706
Pubmed	Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog.	PNMT CYP11B1 CYP11B2	1.85e-05	12	155	3	20118198
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	1.97e-05	2	155	2	23150505
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	1.97e-05	2	155	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	1.97e-05	2	155	2	21164264
Pubmed	Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.	FRS2 RET	1.97e-05	2	155	2	11390647
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	1.97e-05	2	155	2	8645611
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	1.97e-05	2	155	2	11448776
Pubmed	TMEM16A drives renal cyst growth by augmenting Ca2+ signaling in M1 cells.	ANO1 PKD1	1.97e-05	2	155	2	32185407
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	1.97e-05	2	155	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	1.97e-05	2	155	2	20634641
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	1.97e-05	2	155	2	1303253
Pubmed	How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex.	PDHX DLD	1.97e-05	2	155	2	16263718
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	1.97e-05	2	155	2	1741400
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	1.97e-05	2	155	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	1.97e-05	2	155	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	1.97e-05	2	155	2	26324851
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	1.97e-05	2	155	2	7669222
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	1.97e-05	2	155	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	1.97e-05	2	155	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	1.97e-05	2	155	2	2256920
Pubmed	Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells.	FRS2 PKD1	1.97e-05	2	155	2	28077787
Pubmed	Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.	PDHX DLD	1.97e-05	2	155	2	16442803
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	1.97e-05	2	155	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	1.97e-05	2	155	2	22217843
Pubmed	Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease.	LCN2 PKD1	1.97e-05	2	155	2	28341240
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	1.97e-05	2	155	2	16396990
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	1.97e-05	2	155	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	1.97e-05	2	155	2	1518866
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	1.97e-05	2	155	2	23761669
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	1.97e-05	2	155	2	2592361
Pubmed	Cell migration by a FRS2-adaptor dependent membrane relocation of ret receptors.	FRS2 RET	1.97e-05	2	155	2	18189271
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	1.97e-05	2	155	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	1.97e-05	2	155	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	1.97e-05	2	155	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	1.97e-05	2	155	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	1.97e-05	2	155	2	15731365
Pubmed	Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo.	LCN2 PKD1	1.97e-05	2	155	2	18974761
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	1.97e-05	2	155	2	17651452
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	1.97e-05	2	155	2	34743356
Pubmed	Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domain.	DOK1 RET	1.97e-05	2	155	2	14607833
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	1.97e-05	2	155	2	20339375
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	1.97e-05	2	155	2	20808686
Pubmed	Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.	ANO1 PKD1	1.97e-05	2	155	2	32859916
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	1.97e-05	2	155	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	1.97e-05	2	155	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	1.97e-05	2	155	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	1.97e-05	2	155	2	26066897
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	1.97e-05	2	155	2	18651133
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	1.97e-05	2	155	2	22083159
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	1.97e-05	2	155	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	1.97e-05	2	155	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	1.97e-05	2	155	2	38341019
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	1.97e-05	2	155	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	1.97e-05	2	155	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	1.97e-05	2	155	2	19820005
Pubmed	Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok.	DOK1 RET	1.97e-05	2	155	2	18353552
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	1.97e-05	2	155	2	22622494
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	1.97e-05	2	155	2	15062555
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	1.97e-05	2	155	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	1.97e-05	2	155	2	17075029
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	1.97e-05	2	155	2	15507509
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	1.97e-05	2	155	2	16041389
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	1.97e-05	2	155	2	17296872
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	1.97e-05	2	155	2	18039983
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	1.97e-05	2	155	2	19029289
Pubmed	Pyruvate dehydrogenase E3 binding protein deficiency.	PDHX DLD	1.97e-05	2	155	2	11935326
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	1.97e-05	2	155	2	15522937
Pubmed	Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.	SPAG5 CEP170 CEP152	2.40e-05	13	155	3	26297806
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	DLGAP2 AGAP5 CLASP1 BMP2K ADGRV1 AP1B1 PTPRN2 PPP1R9B AGAP7P AGAP4	2.51e-05	430	155	10	32581705
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	STK36 TRIP12 AARS2 PTPRN2 CEP152 TANGO6	2.69e-05	130	155	6	12421765
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP53 AGAP5 LMTK2 ADGRV1 ANKRD50 INTS5 NBEAL2 TTLL4 AGAP7P ARHGAP20 AGAP4	2.74e-05	529	155	11	14621295
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP5 AGAP7P AGAP4	3.05e-05	14	155	3	22453919
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	CLASP1 SPAG5 FAM120A CEP152 LTV1 TRAK2 SNX2	4.49e-05	209	155	7	36779422
Pubmed	Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.	CYP11B1 CYP11B2 APOA4	4.66e-05	16	155	3	10391210
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TANC2 DLGAP2 DMXL2 SPTAN1 GRAMD1A ETFA LMTK2 HUWE1 SHISA7 PDHX RPS6KC1 CEP170 CELSR2 DLD PPP1R9B PCDH8	5.31e-05	1139	155	16	36417873
Pubmed	Molecular detection of maturation stages in the developing kidney.	SEMA3G RET LCN2	5.64e-05	17	155	3	33197428
Pubmed	Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage.	PNMT CHGB RET	5.64e-05	17	155	3	18094025
Pubmed	Role of Dok1 in cell signaling mediated by RET tyrosine kinase.	DOK1 RET	5.90e-05	3	155	2	12087092
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	5.90e-05	3	155	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	5.90e-05	3	155	2	16118390
Pubmed	Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals.	ANO1 PKD1	5.90e-05	3	155	2	34199520
Pubmed	Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality.	PDHX DLD	5.90e-05	3	155	2	9405644
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	5.90e-05	3	155	2	17984374
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	5.90e-05	3	155	2	25637021
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	5.90e-05	3	155	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	5.90e-05	3	155	2	33271253
Interaction	TOP3B interactions	TANC2 STK36 CRYBG2 ERCC2 SPTAN1 ETFA LMTK2 SPATA20 SLC10A3 ANKLE1 HUWE1 PCNX2 CDR2L MST1R INTS5 HEG1 KMT2D FAM120A CELSR2 ZBED4 MROH6 SETD5 NBEAL2 TTLL4 TLN1 SVIL PKD1 NPRL3 PPP1R9B	1.32e-06	1470	151	29	int:TOP3B
Interaction	YWHAH interactions	TANC2 USP53 CLASP1 ZC3H13 SPTAN1 LMTK2 GIGYF1 LBR HUWE1 PTPN21 TRIP12 ENKD1 GAB2 CDR2L CEP170 MST1R AKAP9 AARS2 PARD6A SVIL DLD PPP1R9B CEP152 SNX2	2.34e-06	1102	151	24	int:YWHAH
Interaction	SCNM1 interactions	TRAF1 GIGYF1 LCN2 CDR2L AKAP9 COG6 USH1G BEND7 LNX1 CCDC33	2.41e-06	197	151	10	int:SCNM1
Interaction	SPAG5 interactions	CLASP1 DTNBP1 ENKD1 SPAG5 CEP170 TTC23 COG6 ZNF385C CCDC33	1.67e-05	195	151	9	int:SPAG5
Interaction	C2CD4B interactions	ADGRV1 PHKB CELSR2 SVIL ALPK2	1.90e-05	44	151	5	int:C2CD4B
Interaction	WHAMMP3 interactions	DMXL2 DTNBP1 SPAG5 CDR2L AKAP9 COG6 CEP152	3.20e-05	119	151	7	int:WHAMMP3
Interaction	KXD1 interactions	DTNBP1 SPAG5 CDR2L PPP1R9B TRAK2 LAMTOR1 LNX1 CCDC33	4.34e-05	170	151	8	int:KXD1
Interaction	AP3S2 interactions	TCIRG1 HUWE1 DTNBP1 LAMTOR1	5.39e-05	28	151	4	int:AP3S2
GeneFamily	Ankyrin repeat domain containing	TANC2 AGAP5 ANKLE1 ANKRD50 ANKRD53 GABPB2 ASB9 USH1G AGAP7P AGAP4	7.66e-07	242	98	10	403
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	8.69e-05	3	98	2	1007
GeneFamily	EF-hand domain containing\|Spectrins	SPTAN1 SPTBN5	6.00e-04	7	98	2	1113
GeneFamily	ArfGAPs	AGAP5 AGAP7P AGAP4	7.49e-04	33	98	3	395
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AGAP5 GAB2 GAB3 RASA4B AGAP7P AGAP4	8.97e-04	206	98	6	682
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	1.27e-03	10	98	2	830
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	LMTK2 RET MST1R	1.32e-03	40	98	3	321
GeneFamily	Non-clustered protocadherins	PCDH17 PCDH8	1.85e-03	12	98	2	21
GeneFamily	Tubulin tyrosine ligase family	TTLL4 TTLL10	2.54e-03	14	98	2	779
GeneFamily	Galectins	LGALS12 LGALS7	2.92e-03	15	98	2	629
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP4	3.75e-03	17	98	2	1291
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 GRAMD1A PCDH17 HEG1 RASA4 SERPING1 CLN6 EXOC3L2	5.02e-07	199	155	8	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPS1 DACT2 ANO1 RET HEG1 SVIL PCDH8	2.84e-06	176	155	7	95d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPS1 DACT2 ANO1 RET HEG1 SVIL PCDH8	3.18e-06	179	155	7	3b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|metastatic_Brain / Location, Cell class and cell subclass	CRIM1 SEMA3G SHROOM4 HEG1 ASB9 KIF3C ARHGAP20	3.95e-06	185	155	7	ad52970e88e8947ef256095bd4b40229b912d58a
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRIM1 GRAMD1A PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	5.22e-06	193	155	7	c0f0052c24b7fe9e21d2bc6c38047a8e755f87b6
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGFAC PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1 RASA4	5.22e-06	193	155	7	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRIM1 GRAMD1A PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	5.22e-06	193	155	7	682ce63b73a7d02eef240673db67058d7507f744
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	DMXL2 BMP2K TRPS1 GAB2 CEP170 AP1B1 EEPD1	5.58e-06	195	155	7	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	TANC2 USP53 CRIM1 ZC3H13 TRIP12 FAM120A AKAP9	6.37e-06	199	155	7	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	TANC2 CRIM1 BAZ2B ZC3H13 TRIP12 FAM120A AKAP9	6.37e-06	199	155	7	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	TANC2 USP53 CRIM1 BAZ2B ZC3H13 FAM120A AKAP9	6.37e-06	199	155	7	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	TANC2 USP53 CRIM1 ZC3H13 ETFA FAM120A AKAP9	6.37e-06	199	155	7	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPS1 DACT2 ANO1 RET HEG1 SVIL PCDH8	6.59e-06	200	155	7	2441a36d363b799a4692aa697f969cda056c2d60
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPS1 DACT2 ANO1 RET HEG1 SVIL PCDH8	6.59e-06	200	155	7	c7bca638229bd4fd2414171e73fa949e36a10a92
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SCUBE3--L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPS1 DACT2 ANO1 RET HEG1 SVIL PCDH8	6.59e-06	200	155	7	d841dbe2297c3bf62f49bae5921662cd6a47e5c2
ToppCell	TCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3\|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9	TANC2 FRS2 CHGB KMT2D COG6 SVIL	7.90e-06	135	155	6	ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-5\|TCGA-Brain / Sample_Type by Project: Shred V9	CHGB ADGRV1 NALF1 SYT14 INSYN2B SMCR5	8.60e-06	137	155	6	a7c76201b8901b2ef7ebbb4dfe0cec0dc4534ef5
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1-41\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	WDR7 FRS2 CLASRP LRRN3 TTC23 CTU1	1.93e-05	158	155	6	6d2709b387945c015faa223c20d22b52a4082140
ToppCell	ICU-SEP-Myeloid-cDC2\|ICU-SEP / Disease, Lineage and Cell Type	RPS6KC1 RASA4B ARHGAP20 LNX1 ELMOD1 PROC	3.44e-05	175	155	6	c44fd1cc827296de7300d4a60399bb945089a170
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PNMT CHGB LGALS7 RASA4B TTLL10 PROC	4.02e-05	180	155	6	d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCDH17 SPAG5 NALF1 ASB9 UBAP1L TANGO6	4.02e-05	180	155	6	40d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPS1 DACT2 ANO1 RET SVIL PCDH8	4.15e-05	181	155	6	7704f236831cffe4f2a75d4c461eb88b4177e206
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRPS1 DACT2 ANO1 RET SVIL PCDH8	4.15e-05	181	155	6	153709b4dd3d81e09f251fa8765b58bed1932fda
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PCDHA6 INSYN2B ALPK2 PROC	4.64e-05	57	155	4	5ae53d915bee8a5fc7936d2a46517da1b6abbf79
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2-Inhibitory_Gad1Gad2_Htr3a.Chrm2_(Interneuron,__(candidate_CGE-derived_10))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PCDHA6 INSYN2B ALPK2 PROC	4.64e-05	57	155	4	e61b10212685e5217550db0812141a1f3f6567c8
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Chrm2-Inhibitory_Gad1Gad2_Htr3a.Chrm2_(Interneuron,__(candidate_CGE-derived_10))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PCDHA6 INSYN2B ALPK2 PROC	4.64e-05	57	155	4	f5edb5e8eddc51e0b8040e88baa5d8971871f9ea
ToppCell	PCW_05-06-Neuronal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CHGB ADGRV1 RET PCDH17 SYT14 KIAA1755	4.97e-05	187	155	6	03a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RET PKHD1L1 SPAG5 INTS5 UBAP1L ELMOD1	5.28e-05	189	155	6	0739baad9a7da511dd3d7249f84299aee88370a1
ToppCell	human_hepatoblastoma-Inflammatory_Monocytes\|World / Sample and Cell Type and Tumor Cluster (all cells)	TANC2 DMXL2 TRPS1 GAB2 GAB3 INSYN2B	5.59e-05	191	155	6	3b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	CRIM1 PKHD1L1 PCDH17 SHROOM4 NALF1 LNX1	5.59e-05	191	155	6	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HGFAC LGALS12 PTPRN2 RASA4 EEPD1 PROC	5.93e-05	193	155	6	6a9bce5064938b5b84ad57b4fd4a7841afe100c8
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	FRS2 ADGRV1 HUWE1 ANKRD50 FAM120A AKAP9	5.93e-05	193	155	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 BAZ2B TCIRG1 NBEAL2 TLN1 PPP1R9B	5.93e-05	193	155	6	1db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCell	IPF-Endothelial-VE_Arterial\|IPF / Disease state, Lineage and Cell class	CRIM1 PNMT SEMA3G PCDH17 SHROOM4 HEG1	5.93e-05	193	155	6	bf83b1fe9d38408f30eee4eb634341c04ef82791
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	5.93e-05	193	155	6	9ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCell	IPF-Endothelial-VE_Arterial\|World / Disease state, Lineage and Cell class	CRIM1 PNMT SEMA3G PCDH17 SHROOM4 HEG1	5.93e-05	193	155	6	70a9aadda83a97e06e9bc2d1327ce60dd3c58767
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TANC2 PLB1 TRPS1 ANO1 LGALS7 CELSR2	5.93e-05	193	155	6	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KATNAL2 LCN2 PTPRN2 EEPD1 CLN6 CCDC33	6.10e-05	194	155	6	e0228f593c3493175962a4817500d4337ddc4e88
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 BAZ2B TCIRG1 NBEAL2 TLN1 PPP1R9B	6.10e-05	194	155	6	a94f9f7179a5733e3c378ff8b337e288785433a1
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DMXL2 BMP2K TRPS1 CEP170 EEPD1 TTLL4	6.27e-05	195	155	6	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR7 RET NALF1 AP1B1 PTPRN2 CLN6	6.27e-05	195	155	6	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP2 DACT2 PCNX2 PTPRN2 ARHGAP20 ELMOD1	6.27e-05	195	155	6	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRIM1 GRAMD1A PCDH17 SHROOM4 HEG1 NALF1	6.27e-05	195	155	6	53b83e16b350100b1d5791a9c42bd98e37cbc0af
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRIM1 PKHD1L1 PCDH17 HEG1 RASA4 RASA4B	6.27e-05	195	155	6	81a98ebb0d43f416f9a8bba580531dc0cfea8f74
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3G PKHD1L1 PCDH17 HEG1 INSYN2B EXOC3L2	6.45e-05	196	155	6	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA3G PKHD1L1 PCDH17 HEG1 INSYN2B EXOC3L2	6.45e-05	196	155	6	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHGB RET GAB2 LRRN3 NALF1 SYT14	6.64e-05	197	155	6	27c044833e471a312a572e0b1c83e4bc8a36e896
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 RASA4	6.64e-05	197	155	6	0542badae77d2f606c13cfaf361319495c354351
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHGB RET GAB2 LRRN3 NALF1 SYT14	6.64e-05	197	155	6	f7eaac1c321710a55e09ffb047a7db2baf7b7e28
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DMXL2 BMP2K TRPS1 CEP170 AP1B1 EEPD1	6.64e-05	197	155	6	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DMXL2 BMP2K TRPS1 CEP170 AP1B1 EEPD1	6.64e-05	197	155	6	304044ace926943b8eb588f686ecbe5d1689a809
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CRIM1 PCDH17 HEG1 NALF1 RASA4 SVIL	6.64e-05	197	155	6	7a1a3839b2c965136663241b0d4e96c64cfb656a
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 RASA4	6.64e-05	197	155	6	a6a64581699cfcb9607b288976fa3b09648725b7
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	6.83e-05	198	155	6	3ae1e2b4ca77b94eaa24a8c990780aff47dface6
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	TANC2 ZC3H13 ETFA CEP170 AKAP9 TRAK2	6.83e-05	198	155	6	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	6.83e-05	198	155	6	fb70a649e4e2edb32967328c1085dc5999c29a33
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 EXOC3L2	7.02e-05	199	155	6	53b6a661d381b1ed3ea96e61e8bd1750de7d9fda
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	7.02e-05	199	155	6	3a4deea6e11a0555d27497b7c9983350797aac69
ToppCell	(00)_Basal-(2)_GFP_FOXI1\|(00)_Basal / shred by cell type by condition	CRIM1 ZC3H13 ETFA FAM120A AKAP9 SERPING1	7.02e-05	199	155	6	19674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell	(06)_OLFM4+\|World / shred by cell type by condition	TANC2 USP53 CRIM1 LCN2 AKAP9 PCDH8	7.02e-05	199	155	6	c773b9180dbfec9c19d4098dd43332e6f6050372
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPTAN1 GIGYF1 AKAP9 TLN1 SERPING1 ALPK2	7.02e-05	199	155	6	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 EXOC3L2	7.02e-05	199	155	6	9c753043024871b1f1436fc39defac4da85e10cd
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TANC2 CEP170 SVIL SERPING1 ELMOD1 SNX2	7.02e-05	199	155	6	fde8e3ba19d19069a4d3b8db55bfe6220cf634d5
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Bronchial_vessel-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 EXOC3L2	7.02e-05	199	155	6	d017dd91f9b10038f1f83753a766e534da2dbe89
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SPTAN1 PCDH17 HEG1 RASA4 CLN6 EXOC3L2	7.22e-05	200	155	6	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	SPTAN1 PCDH17 RASA4 SERPING1 CLN6 EXOC3L2	7.22e-05	200	155	6	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	7.22e-05	200	155	6	84e145619a500530f42ed0fe72468ae95f4cbf1e
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1 EXOC3L2	7.22e-05	200	155	6	cb00760ae75c30b1cb8526534aabd4ffc7c21000
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	TRAF1 CRIM1 SHROOM4 HEG1 TLN1 SVIL	7.22e-05	200	155	6	a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3G PCDH17 SHROOM4 HEG1 NALF1 RASA4	7.22e-05	200	155	6	cd3c638961144a2fc91c437a173cc37c7452fa74
ToppCell	Biopsy_Control_(H.)-Endothelial\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	PNMT SEMA3G PKHD1L1 PCDH17 SHROOM4 HEG1	7.22e-05	200	155	6	6a9b6a4b4f204598290ae21c87ddb42ac95dfc4c
ToppCell	distal-Endothelial-Vein-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	7.22e-05	200	155	6	ff88d28162e0231d5dac0e0c6bec98fa8da58a23
ToppCell	medial-Endothelial-Vein-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	7.22e-05	200	155	6	3f689029f5bc7db0af50a405f1e252aeec529077
ToppCell	distal-2-Endothelial-Vein\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	7.22e-05	200	155	6	2785225956d2422acab90e99b7debe3709cf3308
ToppCell	medial-Endothelial-Vein\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	7.22e-05	200	155	6	1163e5f6dfb304c94bf8885629350454f4b6bee8
ToppCell	distal-Endothelial-Vein\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	7.22e-05	200	155	6	6acf7afe122f81a95c4c66f4d0878d997b57127a
ToppCell	medial-2-Endothelial-Vein\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CRIM1 PKHD1L1 PCDH17 SHROOM4 HEG1 NALF1	7.22e-05	200	155	6	49da4e3ff10262a492c2cf566a7f2e35e418bfda
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_alveolar-Dividing_AT2\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PLIN4 WDR7 LCN2 CELSR2 BEND7 AGAP4	7.22e-05	200	155	6	befc25cbcbac2c02e5fd33d6e78e59979050090c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	CLASP1 FBXL8 LMTK2 AARS2 ZNF385C	1.39e-04	142	155	5	ae495c8dd733f0fde66bddc281606543f21c0d4b
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LGALS12 NALF1 KIF3C MTFR2 PROC	1.44e-04	143	155	5	d0ed8c25da1327085e042c2e03cb7503e2c52ce0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LGALS12 NALF1 KIF3C MTFR2 PROC	1.44e-04	143	155	5	8900b92a24289204b9ec7baccc11594fec7694f1
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|367C / Donor, Lineage, Cell class and subclass (all cells)	TRAF1 BMP2K AARS2 PKD1 TRAK2	1.75e-04	149	155	5	41f28138bde45d0b814e116837e5a32b5e80d54a
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	STMND1 SPTBN5 SYT14 CFAP99 CCDC33	1.92e-04	152	155	5	854c841c1fc6300b7e9be9c98cbf9b0ce2678690
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AP1B1 RASA4 MTFR2 LAMTOR1 SNX2	2.10e-04	155	155	5	93bfcf5c12cbb61a1e0444312afd2aa411a8bf50
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP53 ENKD1 CLASRP LNX1 SNX2	2.23e-04	157	155	5	6730b775308f45a2f3946016bdbb7f8e5b5efe49
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	STK36 KATNAL2 PLB1 TG COG6	2.36e-04	159	155	5	b9d34b9ed8db798f5ea93c44b469cae499403cb8
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM4 PHKB LRRN3 RASA4 CCDC62	2.36e-04	159	155	5	4000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DOK1 SEMA3G ANKRD53 CDR2L TTC23	2.36e-04	159	155	5	b05fda31b77536a1878f55d3199563b53f9420b2
ToppCell	facs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHROOM4 PHKB LRRN3 RASA4 CCDC62	2.36e-04	159	155	5	7619d0d49738dd08daf01b42664691a5323aa793
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRYBG2 LBR LGALS7 TG SYT14	2.43e-04	160	155	5	ec81814f3a475ba9bc049cb793bf93bc0b650d37
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma\|TCGA-Brain / Sample_Type by Project: Shred V9	CHGB NALF1 PTPRN2 SYT14 SMCR5	2.50e-04	161	155	5	5f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCell	facs-Heart-LV-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPATA20 APOA4 LCN2 IRX4 PTPRN2	2.65e-04	163	155	5	648d5439811b64412bc4678646f216105b90b9a1
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXC9 GAB3 SMCR5 AGAP4 PCDH8	2.72e-04	164	155	5	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|356C / Donor, Lineage, Cell class and subclass (all cells)	DLGAP2 TG AARS2 PROC ZNF697	2.80e-04	165	155	5	35a6de30438de364ccca948fc932da541a69ef89
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-im_megakaryocyte2_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LGALS12 LCN2 PKHD1L1 NBEAL2 EXOC3L2	2.80e-04	165	155	5	d2ab667ff53f538b12ee4e07ea4b4d118600a228
ToppCell	facs-Trachea-nan-18m-Epithelial-mucus_secreting_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GIGYF1 GGT1 TG BEND7 ALPK2	2.80e-04	165	155	5	7e7643834ed483aec04f513cca38d6367fda9ff8
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l22\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SHROOM4 PHKB LRRN3 RASA4 CCDC62	2.88e-04	166	155	5	bcdaab49bde5beba750b76fdcc3781a3c12c4fff
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-mature_NK_T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SHROOM4 PHKB LRRN3 RASA4 CCDC62	2.88e-04	166	155	5	5e3b998d740b24f790fad37350d704ca0ea10b77
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANO1 PKHD1L1 LGALS7 PCNX2 SERPING1	2.96e-04	167	155	5	c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANO1 PKHD1L1 SHISA7 LGALS7 PCNX2	2.96e-04	167	155	5	743df5908c1ceb43b34b240d9f9649f30f4142fa
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP7P AGAP4	1.48e-05	10	149	3	DOID:1969 (implicated_via_orthology)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	2.53e-05	2	149	2	C1260386
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	2.53e-05	2	149	2	DOID:0050891 (is_marker_for)
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	7.57e-05	3	149	2	DOID:0050811 (implicated_via_orthology)
Disease	corpus callosum volume measurement	TG MST1R TLN1 PPP1R9B LNX1	1.57e-04	100	149	5	EFO_0010299
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	HGFAC PNMT TRPS1 ETFA CELSR2 RRN3 NPRL3 TANGO6	1.61e-04	303	149	8	EFO_0004612, EFO_0020945
Disease	free cholesterol to total lipids in medium HDL percentage	TRPS1 ETFA CELSR2 RRN3	2.44e-04	60	149	4	EFO_0022282
Disease	Pyruvate dehydrogenase complex deficiency	PDHX DLD	2.51e-04	5	149	2	cv:C0034345
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	2.51e-04	5	149	2	DOID:446 (is_implicated_in)
Disease	urate measurement, bone density	DLGAP2 KATNAL2 PLB1 WDR7 BAZ2B DTNBP1 PCDH17 TG RNF6 PTPRN2 KIAA1755	3.22e-04	619	149	11	EFO_0003923, EFO_0004531
Disease	Conn Syndrome	CYP11B1 CYP11B2	3.75e-04	6	149	2	C1384514
Disease	clubfoot (implicated_via_orthology)	TCIRG1 RET	3.75e-04	6	149	2	DOID:11836 (implicated_via_orthology)
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	3.75e-04	6	149	2	C0020428
Disease	resting heart rate, chronic obstructive pulmonary disease	PLB1 ADGRV1 GAB2	4.64e-04	30	149	3	EFO_0000341, EFO_0004351
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	5.23e-04	7	149	2	EFO_0801973
Disease	myocarditis (biomarker_via_orthology)	CYP11B1 LCN2	5.23e-04	7	149	2	DOID:820 (biomarker_via_orthology)
Disease	leucine-rich repeat-containing protein 15 measurement	CYP11B2 B4GALNT3	5.23e-04	7	149	2	EFO_0801761
Disease	stanniocalcin-1 measurement	CELSR2 B4GALNT3	6.95e-04	8	149	2	EFO_0020753
Disease	Leigh syndrome	PDHX DLD	6.95e-04	8	149	2	cv:C0023264
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	8.91e-04	9	149	2	EFO_0802936
Disease	androstenedione measurement	CYP11B1 CYP11B2	1.11e-03	10	149	2	EFO_0007972
Disease	C-reactive protein measurement	HGFAC DMXL2 ERCC2 TRPS1 ETFA TRIP12 PCDH17 CLASRP MST1R CELSR2 MROH6 SETD5 EEPD1 PKD1 EXOC3L2	1.20e-03	1206	149	15	EFO_0004458
Disease	Neurodevelopmental Disorders	TANC2 KATNAL2 TRIP12 SETD5	1.29e-03	93	149	4	C1535926
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	1.35e-03	11	149	2	EFO_0801461
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	1.35e-03	11	149	2	EFO_0021862
Disease	triacylglycerol 58:12 measurement	TRIP12 LNX1	1.62e-03	12	149	2	EFO_0010439
Disease	intracranial aneurysm (is_implicated_in)	KMT2D PKD1	1.62e-03	12	149	2	DOID:10941 (is_implicated_in)
Disease	toxic shock syndrome (is_implicated_in)	SERPING1 PROC	1.90e-03	13	149	2	DOID:14115 (is_implicated_in)
Disease	gamma-glutamylleucine measurement	GGT1 NALF1	1.90e-03	13	149	2	EFO_0021140
Disease	Diverticular Bleeding	ETFA NALF1	1.90e-03	13	149	2	C4505353
Disease	Diverticular Diseases	ETFA NALF1	1.90e-03	13	149	2	C4317009
Disease	Skin Abnormalities	ERCC2 AP1B1	1.90e-03	13	149	2	C0037268
Disease	breast carcinoma	CLASP1 TRPS1 ETFA LMTK2 ANKLE1 RPS6KC1 NALF1 AKAP9 PTPRN2 MARCHF5 SYT14 TRAK2 CCDC33	2.04e-03	1019	149	13	EFO_0000305
Disease	diastolic blood pressure, systolic blood pressure	HGFAC CRIM1 TRPS1 FRS2 ANO1 CCDC62 SVIL LNX1 SNX2 TANGO6	2.21e-03	670	149	10	EFO_0006335, EFO_0006336
Disease	autosomal dominant polycystic kidney disease (is_marker_for)	LCN2 SERPING1	2.21e-03	14	149	2	DOID:898 (is_marker_for)
Disease	phospholipids in medium VLDL measurement	HGFAC TRPS1 CELSR2	2.33e-03	52	149	3	EFO_0022154
Disease	serum gamma-glutamyl transferase measurement	HGFAC PLB1 CYP11B1 LMTK2 PDHX GGT1 CELSR2 NBEAL2 TLN1 SVIL PKD1 ALPK2	2.39e-03	914	149	12	EFO_0004532
Disease	reticulocyte count	CLASP1 BMP2K GRAMD1A TRPS1 TCIRG1 SPATA20 AP1B1 EEPD1 PKD1 NPRL3 EXOC3L2 ZNF385C HBM	2.54e-03	1045	149	13	EFO_0007986
Disease	3-hydroxyanthranilic acid measurement	TG PCNX2	2.55e-03	15	149	2	EFO_0010447
Disease	free cholesterol to total lipids in large HDL percentage	HGFAC CELSR2 RRN3	2.88e-03	56	149	3	EFO_0022279
Disease	peripheral arterial disease, traffic air pollution measurement	TANC2 DLGAP2 TRPS1 COG6 PCDH8	3.11e-03	194	149	5	EFO_0004265, EFO_0007908
Disease	health study participation	PCDH17 CEP170 MST1R FAM120A TANGO6	3.18e-03	195	149	5	EFO_0010130
Disease	response to homoharringtonine, cytotoxicity measurement	DACT2 RNF6	3.28e-03	17	149	2	EFO_0006952, EFO_0006996
Disease	cortical surface area measurement	TANC2 BAZ2B ZC3H13 ETFA LGALS12 ADGRV1 TG NALF1 PKD1 KIAA1755 PPP1R9B LNX1 PROC CCDC33 TANGO6	3.40e-03	1345	149	15	EFO_0010736
Disease	phospholipids in small VLDL measurement	HGFAC TRPS1 CELSR2	3.50e-03	60	149	3	EFO_0022146
Disease	FEV/FEC ratio	CRIM1 TRPS1 ANO1 PDHX GAB2 TG SPTBN5 NALF1 TTC23 SVIL SERPING1 ARHGAP20 LNX1 CTU1	3.82e-03	1228	149	14	EFO_0004713
Disease	hydrocephalus (implicated_via_orthology)	STK36 CELSR2	4.09e-03	19	149	2	DOID:10908 (implicated_via_orthology)
Disease	total lipids in very large HDL measurement	HGFAC ETFA CELSR2	4.58e-03	66	149	3	EFO_0022312
Disease	total lipids in small VLDL	HGFAC TRPS1 CELSR2	4.77e-03	67	149	3	EFO_0022148
Disease	gastric ulcer	PDHX GGT1	4.99e-03	21	149	2	EFO_0009454

Protein segments in the cluster

Peptide	Gene	Start	Entry
DSVSRATLAAEPAHS	USH1G	281	Q495M9
HFNLTDPERASESAL	ZNF280A	236	P59817
REPAHSELLDAASSS	ZNF385C	166	Q66K41
DADRSLSIPDEQLHS	AGAP4	156	Q96P64
ARALHPAAVSAAAEF	CEP170	1541	Q5SW79
PAREASASALDHVTR	EXOC3L2	151	Q2M3D2
EASARPSGTQDELHS	DCANP1	101	Q8TF63
RNDSLLQTLSPDSEH	AKAP9	3681	Q99996
ALNAIVAKDPASRHA	CDR2L	321	Q86X02
LLSDNGSESLPHSAA	CEP152	1481	O94986
PAGADSLRAQSHRAE	ENKD1	306	Q9H0I2
DATAAQQVLSDSLHP	ELMOD1	191	Q8N336
ARSVEALTPLHVAAA	ANKLE1	71	Q8NAG6
SPLHAVARTASEELA	ASB9	201	Q96DX5
NLALLRASTDPTARH	CCDC33	166	Q8N5R6
SPASELIAIQDSHSL	CCDC62	566	Q6P9F0
AASHVDSSNALPRDE	B4GALNT3	301	Q6L9W6
SAAQEERNLVPTAHS	ALPK2	1161	Q86TB3
LAHSPEDAESALADS	ALPK2	1296	Q86TB3
ESSAHALERKSDNPL	BAZ2B	1856	Q9UIF8
AHINATLTVLASDDP	ADGRV1	1961	Q8WXG9
LETAAAQRHLPESQS	DLGAP2	676	Q9P1A6
VAALSEIAESHPSSN	AP1B1	181	Q10567
HTDNNGRTPLLAAAS	ANKRD50	776	Q9ULJ7
ATNSSSELFRLAAHP	DMXL2	2361	Q8TDJ6
EARDHGTPALTASAS	CELSR2	581	Q9HCU4
RASSDKNVDSLSAPH	BMP2K	656	Q9NSY1
SAQHSPSSLRRDLLA	EEPD1	106	Q7L9B9
VTPNLSRASSDADHG	GRAMD1A	276	Q96CP6
LQDLREAHSSSPAGS	RASA4	776	O43374
DSGAPAHLESNATVR	PCDH17	556	O14917
LQDLREAHSSSPAGS	RASA4B	776	C9J798
SGALDRHQDSPVTSL	IRX4	421	P78413
PKSARRSASASHQAD	LBR	91	Q14739
LSQAPASDVLARTHT	PTPRN2	161	Q92932
DREEAPAHNLFLTAT	PCDHA6	201	Q9UN73
DAALHFNPRLDTSEV	LGALS7	46	P47929
NADSLQASLRPHADE	APOA4	171	P06727
AERSRQAALLHVSAP	CFAP99	586	D6REC4
PDLADHLSAQATALA	ANKRD53	61	Q8N9V6
ISHDNEDLLASRFPA	HOXC9	16	P31274
VHRSQRDPLAADESA	LTV1	21	Q96GA3
SAAATALPLSHGAAR	GIGYF1	461	O75420
ADSDSPSTQLRAHEL	RPS6KC1	556	Q96S38
FSPDVRSHLAAATAL	KIAA1755	801	Q5JYT7
LLTAHAASSSLPRDD	GAB3	146	Q8WWW8
HASLASASLRPATVA	KIF3C	776	O14782
SARAASQATRHLSEP	PCNX2	2071	A6NKB5
QAAHAPVTLRASFAD	LGALS12	246	Q96DT0
PAARNILEKHSLDAS	PDHX	186	O00330
TPATLSADLAHFSEN	SLC10A3	176	P09131
LSVRVLDANDHSPAF	PCDH8	231	O95206
RAEAASAVLSNSPHS	MUC3A	36	Q02505
ALENHQSESSDLPRI	KATNAL2	486	Q8IYT4
ALATSHTDREATPDG	DTNBP1	331	Q96EV8
SEHERAAILSVPAAQ	NPRL3	491	Q12980
DDETPQLSAHALAAL	EEF1AKMT1	6	Q8WVE0
SPESAAHLIQASERR	LNX1	441	Q8TBB1
EANPLADHVSATRIL	MARCHF5	196	Q9NX47
SAARETDAHLANPVL	ERCC2	296	P18074
SALHNSSDLELRATP	LMTK2	1166	Q8IWU2
ALPVALVSSLEAASH	IL17C	61	Q9P0M4
LLRLHDPSRDAAESS	MROH6	536	A6NGR9
ATARASHLFDNPATV	ANO1	396	Q5XXA6
ARAPSHSESALNNDS	FAM120A	1071	Q9NZB2
NPHLNALSTDSACRR	FAM120A	1091	Q9NZB2
HAASDAPENLTLLAE	HEG1	151	Q9ULI3
ALSAQAVLRLSSHEA	OR52P1	221	Q8NH57
SSSLREALVPLVADH	HGFAC	551	Q04756
ADATLSAQATPLLHA	HUWE1	881	Q7Z6Z7
AVNSRLHSRELSPEA	CCDC167	31	Q9P0B6
SLQEVSEPLTAARHA	PTPN21	616	Q16825
LTNDDSLHRALASGP	PARD6A	71	Q9NPB6
LHAQAQDSTSDLIPA	LCN2	16	P80188
APLDSVFSSSERAHQ	PROC	21	P04070
HDSSVVPLDARQADF	COG6	456	Q9Y2V7
IQHDPLTTDLRSSAD	CXXC1	641	Q9P0U4
AVAPQESHRTSAQAL	DACT2	576	Q5SW24
LDTAQRSHLLAADAP	DOK1	91	Q99704
VSASDILQESAIHSP	CUSTOS	166	Q96C57
ASLSHAILEALAAPD	FBXL8	201	Q96CD0
SVHVPLEARVSNAES	FRS2	211	Q8WU20
EAARPSAVLDLVHSA	CTU1	256	Q7Z7A3
EDSQSPHLASVGSLR	CRYBG2	1196	Q8N1P7
RQESLAAAASISEHP	CYP11B1	341	P15538
DNRLHPSEDSSLDSI	CRIM1	926	Q9NZV1
DADRSLSIPDEQLHS	AGAP7P	156	Q5VUJ5
AHPTLSEAFREANLA	DLD	486	P09622
HSPDLAIRDTFVNAS	SERPING1	226	P05155
HSLPSARTDEQALLS	LAMTOR1	41	Q6IAA8
SALQAAEHTSPEESR	BEND7	251	Q8N7W2
RQESLAAAASISEHP	CYP11B2	341	P19099
QHVDNLRAALSPLAD	HBM	71	Q6B0K9
LRDPADASEAHESSS	CHGB	86	P05060
SLLPRESRSHNTDAA	PHKB	281	Q93100
PADATALDVSHNLLR	PKD1	66	P98161
SPAELSSSSQHLLRE	GAB2	141	Q9UQC2
LAEASVPLSNSHRAT	GABPB2	231	Q8TAK5
VANAHSSARARPAAD	PLIN4	21	Q96Q06
PSRLAAAQQLSDSGH	ARHGAP20	311	Q9P2F6
LHTRLPGDAAASSSA	RRN3	6	Q9NYV6
DHTALSRALSQLAEV	SNX2	356	O60749
EALSRTHNSRLPLAD	SYT14	101	Q8NB59
STALAADFRVNHVDP	SPAG5	251	Q96R06
LSATRQAHDLSPAAE	SVIL	211	O95425
ENSHAAQSARIPSDV	LRRN3	561	Q9H3W5
STLVIAEHANDSLAP	ETFA	21	P13804
AEHANDSLAPITLNT	ETFA	26	P13804
APGRHSSSLSNVLED	NBEAL2	1401	Q6ZNJ1
AAHRLARLDTNSPSI	NBEAL2	2351	Q6ZNJ1
VDERSPLLSASHSGN	PIP4P2	6	Q8N4L2
DIPLSDSNRDHTANR	RNF6	171	Q9Y252
ADRPSLLNSGHSDLA	SETD5	931	Q9C0A6
RARSSECLSQAPESH	SHROOM4	661	Q9ULL8
PTARASLAASHSNLL	SHISA7	441	A6NL88
AAADHSRTPSLLASS	SMCR5	61	Q8TEV8
PNSVAATSSAHLEDL	TANC2	266	Q9HCD6
ASLLDTNRRHTAAVP	INTS5	726	Q6P9B9
LHSEDPRLQDSTTLA	PLB1	291	Q6P1J6
DQEHPAIRTLSARAA	RANBP6	191	O60518
NNSAIATPHLDALAR	SGSH	41	P51688
AHALDPASQAALQTS	AARS2	731	Q5JTZ9
AAATHALSAPAEVRL	STK36	826	Q9NRP7
SHQLEELQEPARSTA	SPTBN5	546	Q9NRC6
DRSLSIPDEQLHSFA	AGAP5	181	A6NIR3
SVSADEAARTAPFHL	CLN6	31	Q9NWW5
AAEEAASTLASSIHP	CLASP1	1406	Q7Z460
HLDSAVALAAESPVN	CLASRP	51	Q8N2M8
KALPSDNIRHALAES	USP53	91	Q70EK8
AVSPDLASFQRALDH	PNMT	186	P11086
RQHASDALSPVLAEE	TRAK2	76	O60296
PSGDSDLATALHRLS	TRAK2	476	O60296
TLRDSPNVEAAHLAR	TRPS1	826	Q9UHF7
VQAADHLDSISPRGS	nan	236	Q6ZSR9
HLIEPLANAARAEAS	TLN1	1711	Q9Y490
AEPSANSVSAHNLLR	SPATA20	641	Q8TB22
AEADRLQQSHPLSAT	SPTAN1	316	Q13813
VRDPDGAHRASSLAN	TANGO6	966	Q9C0B7
EHAIDAFRPDLSSAS	TRAF1	356	Q13077
TNDDPNIELTAAHRS	PKHD1L1	3551	Q86WI1
SRSLAHSFRDLPTND	UBQLNL	106	Q8IYU4
LSSSRAAHLSVDPDQ	MTFR2	186	Q6P444
GSRNSSSLDHPDERA	RET	831	P07949
SHPDTAADLLSALSQ	UBAP1L	256	F5GYI3
HRLAEAAAAASLEPF	ZNF697	211	Q5TEC3
ALRSDSDQSLLHDPR	SEMA3G	211	Q9NS98
LRSDRLLPSANHSDS	STMND1	191	H3BQB6
RSPSQVEAADSAHIV	TTC23	261	Q5W5X9
AAADLGSPSLQHSRD	TRIP12	971	Q14669
GSPSLQHSRDDSLDL	TRIP12	976	Q14669
TVPADASAHIALSTA	TTLL4	276	Q14679
SALSPAAVISHERAQ	TG	2416	P01266
LLNSHRPADSDDTNA	TTLL10	116	Q6ZVT0
SPAADSARSARHALS	WDR7	1246	Q9Y4E6
DDPSALHTRLARLSA	MST1R	271	Q04912
AAAHTDGASERTPLL	TCIRG1	141	Q13488
LRSPSNDSAHRSGDD	ZC3H13	1206	Q5T200
ASSSPDRLTEDLQSH	ZBED4	386	O75132
AAQLRAQISDDTTHP	GGT1	351	P19440
SAEVSNSIHPLDDTR	INSYN2B	226	A6NMK8
HPKDAASARDSERAL	KMT2D	4651	O14686
GESSPAAQAHRLLSA	NALF1	111	B1AL88
PRASSLNENVDHSAL	PPP1R9B	96	Q96SB3