Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	kidney mesenchyme development	SIX4 SIX1 SIX2	1.94e-05	16	69	3	GO:0072074
GeneOntologyBiologicalProcess	regulation of branch elongation involved in ureteric bud branching	SIX4 SIX1	3.30e-05	3	69	2	GO:0072095
GeneOntologyBiologicalProcess	positive regulation of ureteric bud formation	SIX4 SIX1	6.59e-05	4	69	2	GO:0072107
GeneOntologyBiologicalProcess	regulation of ureteric bud formation	SIX4 SIX1	6.59e-05	4	69	2	GO:0072106
GeneOntologyBiologicalProcess	myotome development	SIX4 SIX1	6.59e-05	4	69	2	GO:0061055
GeneOntologyBiologicalProcess	branch elongation involved in ureteric bud branching	SIX4 SIX1	6.59e-05	4	69	2	GO:0060681
GeneOntologyBiologicalProcess	regulation of morphogenesis of a branching structure	LRRK2 SIX4 SIX1 SIX2	6.66e-05	65	69	4	GO:0060688
GeneOntologyBiologicalProcess	regulation of branching involved in ureteric bud morphogenesis	SIX4 SIX1 SIX2	6.90e-05	24	69	3	GO:0090189
GeneOntologyBiologicalProcess	olfactory placode morphogenesis	SIX4 SIX1	1.10e-04	5	69	2	GO:0071699
GeneOntologyBiologicalProcess	olfactory placode development	SIX4 SIX1	1.10e-04	5	69	2	GO:0071698
GeneOntologyBiologicalProcess	trigeminal ganglion development	SIX4 SIX1	1.10e-04	5	69	2	GO:0061551
GeneOntologyBiologicalProcess	regulation of mesonephros development	SIX4 SIX1	1.10e-04	5	69	2	GO:0061217
GeneOntologyBiologicalProcess	olfactory placode formation	SIX4 SIX1	1.10e-04	5	69	2	GO:0030910
GeneOntologyBiologicalProcess	negative regulation of satellite cell differentiation	SIRT2 SIX4	1.10e-04	5	69	2	GO:1902725
GeneOntologyBiologicalProcess	regulation of skeletal muscle cell differentiation	SIRT2 SIX4 SIX1	1.11e-04	28	69	3	GO:2001014
GeneOntologyBiologicalProcess	cranial ganglion development	SIX4 SIX1	1.64e-04	6	69	2	GO:0061550
GeneOntologyBiologicalProcess	fungiform papilla morphogenesis	SIX4 SIX1	1.64e-04	6	69	2	GO:0061197
GeneOntologyBiologicalProcess	negative regulation of skeletal muscle cell differentiation	SIRT2 SIX4	2.29e-04	7	69	2	GO:2001015
GeneOntologyBiologicalProcess	ureteric bud formation	SIX4 SIX1	2.29e-04	7	69	2	GO:0060676
GeneOntologyBiologicalProcess	fungiform papilla development	SIX4 SIX1	2.29e-04	7	69	2	GO:0061196
GeneOntologyBiologicalProcess	regulation of synaptic assembly at neuromuscular junction	SIX4 SIX1	2.29e-04	7	69	2	GO:0008582
GeneOntologyBiologicalProcess	regulation of kidney development	SIX4 SIX1 SIX2	2.78e-04	38	69	3	GO:0090183
GeneOntologyBiologicalProcess	ureteric bud elongation	SIX4 SIX1	3.05e-04	8	69	2	GO:0060677
GeneOntologyBiologicalProcess	skeletal system morphogenesis	INPPL1 IFT80 SIX4 ACVR2B SIX1 SIX2	3.28e-04	277	69	6	GO:0048705
GeneOntologyBiologicalProcess	axonemal dynein complex assembly	SPAG1 CFAP57 DNAH1	3.49e-04	41	69	3	GO:0070286
GeneOntologyBiologicalProcess	regulation of epithelial tube formation	SIX4 SIX1	3.91e-04	9	69	2	GO:1905276
GeneOntologyBiologicalProcess	positive regulation of epithelial tube formation	SIX4 SIX1	3.91e-04	9	69	2	GO:1905278
GeneOntologyBiologicalProcess	protein-RNA complex disassembly	TFIP11 DYRK3	4.88e-04	10	69	2	GO:0032988
GeneOntologyBiologicalProcess	monoubiquitinated protein deubiquitination	USP9X USP1	4.88e-04	10	69	2	GO:0035520
GeneOntologyBiologicalProcess	regulation of neuromuscular junction development	SIX4 SIX1	4.88e-04	10	69	2	GO:1904396
GeneOntologyBiologicalProcess	kidney morphogenesis	LRRK2 SIX4 SIX1 SIX2	5.25e-04	111	69	4	GO:0060993
GeneOntologyBiologicalProcess	synaptic assembly at neuromuscular junction	SIX4 SIX1	5.95e-04	11	69	2	GO:0051124
GeneOntologyBiologicalProcess	embryonic cranial skeleton morphogenesis	SIX4 SIX1 SIX2	7.04e-04	52	69	3	GO:0048701
GeneOntologyBiologicalProcess	tongue morphogenesis	SIX4 SIX1	7.12e-04	12	69	2	GO:0043587
GeneOntologyBiologicalProcess	regulation of skeletal muscle satellite cell proliferation	SIX5 SIX1	8.40e-04	13	69	2	GO:0014842
GeneOntologyBiologicalProcess	metanephric mesenchyme development	SIX4 SIX1	8.40e-04	13	69	2	GO:0072075
GeneOntologyBiologicalProcess	regulation of anatomical structure morphogenesis	KIF13B VIM SPARC DSCAM LRRK2 MKLN1 KNDC1 SIX4 SIX1 SIX2 AMIGO1	9.28e-04	1090	69	11	GO:0022603
GeneOntologyBiologicalProcess	mesonephric tubule formation	SIX4 SIX1	9.78e-04	14	69	2	GO:0072172
GeneOntologyBiologicalProcess	negative regulation of muscle organ development	SFMBT1 SIRT2	9.78e-04	14	69	2	GO:0048635
GeneOntologyBiologicalProcess	skeletal system development	SPARC INPPL1 IFT80 SIX4 ACVR2B SIX1 USP1 SIX2	1.01e-03	615	69	8	GO:0001501
HumanPheno	Hypoplasia of the cochlea	HAAO SIX5 SIX1	1.97e-05	12	24	3	HP:0008586
HumanPheno	Aplasia/Hypoplasia of the cochlea	HAAO SIX5 SIX1	2.55e-05	13	24	3	HP:0011395
HumanPheno	Aplasia/Hypoplasia of the inner ear	HAAO SIX5 SIX1	3.23e-05	14	24	3	HP:0008774
HumanPheno	Abnormal lateral semicircular canal morphology	SIX5 SIX1	6.36e-05	3	24	2	HP:0040106
HumanPheno	Enlarged cochlear aqueduct	SIX5 SIX1	1.27e-04	4	24	2	HP:0011388
Domain	SIX1_SD	SIX5 SIX4 SIX1 SIX2	5.92e-09	7	69	4	PF16878
Domain	SIX1_SD	SIX5 SIX4 SIX1 SIX2	5.92e-09	7	69	4	IPR031701
Domain	SAM_2	SFMBT1 SAMD9 INPPL1 SAMHD1	1.89e-05	43	69	4	PF07647
Domain	SAM	SFMBT1 SAMD9 INPPL1 SAMHD1	3.15e-04	88	69	4	SM00454
Domain	SAM_DOMAIN	SFMBT1 SAMD9 INPPL1 SAMHD1	4.22e-04	95	69	4	PS50105
Domain	SAM	SFMBT1 SAMD9 INPPL1 SAMHD1	4.56e-04	97	69	4	IPR001660
Domain	Hydrolase_3	ATP8B3 ATP10D	5.94e-04	10	69	2	PF08282
Domain	-	SFMBT1 SAMD9 INPPL1 SAMHD1	6.38e-04	106	69	4	1.10.150.50
Domain	Fol_N	SPARC FCGBP	7.24e-04	11	69	2	IPR003645
Domain	FOLN	SPARC FCGBP	7.24e-04	11	69	2	SM00274
Domain	SAM/pointed	SFMBT1 SAMD9 INPPL1 SAMHD1	9.24e-04	117	69	4	IPR013761
Domain	P_typ_ATPase_c	ATP8B3 ATP10D	1.19e-03	14	69	2	IPR032630
Domain	P-type_ATPase_N	ATP8B3 ATP10D	1.19e-03	14	69	2	IPR032631
Domain	P-type_ATPase_IV	ATP8B3 ATP10D	1.19e-03	14	69	2	IPR006539
Domain	PhoLip_ATPase_C	ATP8B3 ATP10D	1.19e-03	14	69	2	PF16212
Domain	PhoLip_ATPase_N	ATP8B3 ATP10D	1.19e-03	14	69	2	PF16209
Domain	SAM_1	SFMBT1 SAMD9 INPPL1	2.04e-03	68	69	3	PF00536
Domain	WD40	WDR75 LRRK2 IFT80 CFAP57 DENND3	3.12e-03	268	69	5	SM00320
Domain	WD40_repeat	WDR75 LRRK2 IFT80 CFAP57 DENND3	3.32e-03	272	69	5	IPR001680
Domain	WD40_repeat_dom	WDR75 LRRK2 IFT80 CFAP57 DENND3	4.82e-03	297	69	5	IPR017986
Domain	Homeobox_CS	SIX5 SIX4 SIX1 SIX2	4.97e-03	186	69	4	IPR017970
Domain	Galactose-bd-like	MKLN1 NGLY1 F8	5.09e-03	94	69	3	IPR008979
Domain	FYVE	ZFYVE16 ZFYVE26	5.12e-03	29	69	2	PF01363
Domain	FYVE	ZFYVE16 ZFYVE26	5.12e-03	29	69	2	SM00064
Domain	-	ATP8B3 ATP10D	6.21e-03	32	69	2	3.40.1110.10
Domain	-	ATP8B3 ATP10D	6.21e-03	32	69	2	2.70.150.10
Domain	Znf_FYVE-rel	ZFYVE16 ZFYVE26	6.99e-03	34	69	2	IPR017455
Pubmed	Six family genes control the proliferation and differentiation of muscle satellite cells.	SIX5 SIX4 SIX1 SIX2	1.50e-11	4	70	4	20696153
Pubmed	Tissue and developmental distribution of Six family gene products.	SIX5 SIX4 SIX1 SIX2	7.51e-11	5	70	4	9551859
Pubmed	Identification and expression of six family genes in mouse retina.	SIX5 SIX4 SIX1 SIX2	7.51e-11	5	70	4	8814301
Pubmed	Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site.	SIX5 SIX4 SIX1 SIX2	2.25e-10	6	70	4	9826681
Pubmed	Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis.	SIX5 SIX4 SIX1 SIX2	2.25e-10	6	70	4	20074369
Pubmed	The expression profile and clinic significance of the SIX family in non-small cell lung cancer.	SIX5 SIX4 SIX1 SIX2	2.25e-10	6	70	4	27821176
Pubmed	Dynamic expression of Six family genes in the dental mesenchyme and the epithelial ameloblast stem/progenitor cells during murine tooth development.	SIX5 SIX4 SIX1 SIX2	2.25e-10	6	70	4	19900183
Pubmed	Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.	SIX5 SIX4 SIX1 SIX2	5.24e-10	7	70	4	12215533
Pubmed	Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins.	SIX5 SIX4 SIX1 SIX2	1.05e-09	8	70	4	11950062
Pubmed	Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.	SIX5 SIX4 SIX1 SIX2	1.05e-09	8	70	4	15634706
Pubmed	Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development.	SIX5 SIX4 SIX1 SIX2	1.05e-09	8	70	4	11313460
Pubmed	Pleiotropic effects in Eya3 knockout mice.	SIX5 SIX4 SIX1 SIX2	1.88e-09	9	70	4	19102749
Pubmed	Dachshund homologues play a conserved role in islet cell development.	VIM SIX5 SIX4 SIX1 SIX2	2.23e-09	27	70	5	20869363
Pubmed	Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders.	SIX4 SIX1 SIX2	7.79e-08	5	70	3	26034287
Pubmed	Overlapping functions of SIX homeoproteins during embryonic myogenesis.	SIX5 SIX4 SIX1 SIX2	1.55e-07	24	70	4	37267426
Pubmed	Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base.	SIX4 SIX1 SIX2	2.72e-07	7	70	3	20515681
Pubmed	Six3 and Six6 activity is modulated by members of the groucho family.	SIX4 SIX1 SIX2	4.34e-07	8	70	3	12441302
Pubmed	Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele.	SIX5 SIX4 SIX1	4.34e-07	8	70	3	30237319
Pubmed	Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis.	SIX4 SIX1 SIX2	9.28e-07	10	70	3	16938278
Pubmed	Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.	SIX1 SIX2	3.99e-06	2	70	2	33281191
Pubmed	The secreted protein acidic and rich in cysteine is a critical mediator of cell death program induced by WIN/TRAIL combined treatment in osteosarcoma cells.	SPARC TNFSF10	3.99e-06	2	70	2	26698404
Pubmed	Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.	LRRK2 PPM1H	3.99e-06	2	70	2	34658337
Pubmed	Cytosolic N-GlcNAc proteins are formed by the action of endo-β-N-acetylglucosaminidase.	ENGASE NGLY1	3.99e-06	2	70	2	32782141
Pubmed	Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells.	ENGASE NGLY1	3.99e-06	2	70	2	25605922
Pubmed	Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress.	ENGASE NGLY1	3.99e-06	2	70	2	31733337
Pubmed	Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.	LRRK2 PPM1H	3.99e-06	2	70	2	37889931
Pubmed	Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene.	ENGASE NGLY1	3.99e-06	2	70	2	28426790
Pubmed	Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation.	SIX4 SIX1	3.99e-06	2	70	2	20601407
Pubmed	Identification of roles for peptide: N-glycanase and endo-beta-N-acetylglucosaminidase (Engase1p) during protein N-glycosylation in human HepG2 cells.	ENGASE NGLY1	3.99e-06	2	70	2	20668520
Pubmed	Expression of three zebrafish Six4 genes in the cranial sensory placodes and the developing somites.	SIX5 SIX4	3.99e-06	2	70	2	11044620
Pubmed	Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors.	SIX4 SIX1 SIX2	6.23e-06	18	70	3	32243674
Pubmed	SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis.	SIX5 SIX4 SIX1	1.01e-05	21	70	3	32591430
Pubmed	[Analysis of GUCA1B,GNGT1 and RGS9 genes in patients with retinitis pigmentosa].	GUCA1B RGS9	1.20e-05	3	70	2	15901556
Pubmed	Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.	SIX5 SIX1	1.20e-05	3	70	2	11978764
Pubmed	Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4.	SIX4 SIX1	1.20e-05	3	70	2	32826305
Pubmed	Mutation screening of the EYA1, SIX1, and SIX5 genes in an East Asian cohort with branchio-oto-renal syndrome.	SIX5 SIX1	1.20e-05	3	70	2	22447252
Pubmed	Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes.	LRRK2 PPM1H	1.20e-05	3	70	2	37133994
Pubmed	Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice.	SIX5 SIX4	1.20e-05	3	70	2	27224259
Pubmed	Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.	SIX1 SIX2	1.20e-05	3	70	2	11734542
Pubmed	Branchiootorenal Spectrum Disorder	SIX5 SIX1	1.20e-05	3	70	2	20301554
Pubmed	Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss.	SIX1 SIX2	1.20e-05	3	70	2	15735644
Pubmed	MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis.	SIX4 SIX1	1.20e-05	3	70	2	27302134
Pubmed	PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.	LRRK2 PPM1H	1.20e-05	3	70	2	31663853
Pubmed	Branchio-oto-renal syndrome: comprehensive review based on nationwide surveillance in Japan.	SIX5 SIX1	1.20e-05	3	70	2	24730701
Pubmed	Mutation screening of the EYA1, SIX1, and SIX5 genes in a large cohort of patients harboring branchio-oto-renal syndrome calls into question the pathogenic role of SIX5 mutations.	SIX5 SIX1	1.20e-05	3	70	2	21280147
Pubmed	Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer.	SIX5 SIX4	1.20e-05	3	70	2	14966291
Pubmed	Phenotype-genotype correlation in patients with typical and atypical branchio-oto-renal syndrome.	SIX5 SIX1	1.20e-05	3	70	2	35046468
Pubmed	Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion.	NAMPT HAAO	1.20e-05	3	70	2	32390008
Pubmed	Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance.	ACLY SIX2	2.39e-05	4	70	2	38007516
Pubmed	Direct molecular regulation of the myogenic determination gene Myf5 by Pax3, with modulation by Six1/4 factors, is exemplified by the -111 kb-Myf5 enhancer.	SIX4 SIX1	2.39e-05	4	70	2	23384562
Pubmed	Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators.	SIX1 SIX2	2.39e-05	4	70	2	26884396
Pubmed	Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.	ENGASE NGLY1	2.39e-05	4	70	2	34215698
Pubmed	Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.	SIRT2 ACLY	2.39e-05	4	70	2	23932781
Pubmed	Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.	SIX1 SIX2	2.39e-05	4	70	2	25670082
Pubmed	A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.	SIX1 SIX2	2.39e-05	4	70	2	30894749
Pubmed	GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles.	GOLPH3L DIPK2A B4GALT4	3.71e-05	32	70	3	34473204
Pubmed	Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4.	SIX4 SIX1	3.98e-05	5	70	2	15955062
Pubmed	Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney.	VIM SIX2	3.98e-05	5	70	2	32017326
Pubmed	Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.	SIX5 SIX4	3.98e-05	5	70	2	10490620
Pubmed	Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors.	SIX1 SIX2	3.98e-05	5	70	2	25670083
Pubmed	Six1 and Six2 of the Sine Oculis Homeobox Subfamily are Not Functionally Interchangeable in Mouse Nephron Formation.	SIX1 SIX2	3.98e-05	5	70	2	35178390
Pubmed	Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs.	SIX4 SIX1	3.98e-05	5	70	2	17592144
Pubmed	Development of gustatory papillae in the absence of Six1 and Six4.	SIX4 SIX1	3.98e-05	5	70	2	21978088
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	VIM MCMBP ZFYVE16 USP9X BMS1 PRPF38A SIX4 USP1 SIX2 PPM1H	4.59e-05	1049	70	10	27880917
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	VIM NAMPT ZFYVE16 ACLY USP9X DYRK3	5.22e-05	327	70	6	15592455
Pubmed	Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.	SIX4 SIX1	5.96e-05	6	70	2	29897331
Pubmed	Pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer.	TNFSF10 SIX1	5.96e-05	6	70	2	27780136
Pubmed	Eya-six are necessary for survival of nephrogenic cord progenitors and inducing nephric duct development before ureteric bud formation.	SIX4 SIX1	5.96e-05	6	70	2	25903664
Pubmed	Expression of Six1 and Six4 in mouse taste buds.	SIX4 SIX1	5.96e-05	6	70	2	20668922
Pubmed	Altered myogenesis in Six1-deficient mice.	SIX4 SIX1	5.96e-05	6	70	2	12668636
Pubmed	The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.	SIX4 SIX1	5.96e-05	6	70	2	10906137
Pubmed	A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance.	SIX1 USP1	8.33e-05	7	70	2	34079090
Pubmed	Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia.	SIX1 SIX2	1.11e-04	8	70	2	10471511
Pubmed	Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets.	SIX1 SIX2	1.11e-04	8	70	2	15183306
Pubmed	Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo.	SIX4 SIX1	1.42e-04	9	70	2	17098221
Pubmed	Six1 is required for the early organogenesis of mammalian kidney.	SIX1 SIX2	1.42e-04	9	70	2	12783782
Pubmed	Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme.	SIX1 SIX2	1.78e-04	10	70	2	16442091
Pubmed	The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.	INPPL1 SAMHD1	1.78e-04	10	70	2	17314030
Pubmed	Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.	SIRT2 USP9X	1.78e-04	10	70	2	34758305
Pubmed	Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.	VIM LRRK2	1.78e-04	10	70	2	19826009
Pubmed	Regulation of metanephric kidney development by growth/differentiation factor 11.	ACVR2B SIX2	1.78e-04	10	70	2	12729564
Pubmed	USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription.	VIM USP9X	2.17e-04	11	70	2	33558705
Pubmed	Embryonic origin and remodeling of the urinary and digestive outlets.	SIX1 SIX2	2.17e-04	11	70	2	23390542
Pubmed	Endofin acts as a Smad anchor for receptor activation in BMP signaling.	ZFYVE16 ACVR2B	2.17e-04	11	70	2	17356069
Pubmed	Homeobox genes and connective tissue patterning.	SIX1 SIX2	2.17e-04	11	70	2	7720577
Pubmed	Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects.	SIX4 SIX1	2.17e-04	11	70	2	17300925
Pubmed	Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape.	VIM SIX2	2.17e-04	11	70	2	39009564
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	NAMPT FCGBP TNFSF10 CD163L1 BLNK IRAG2 SAMHD1 F8	2.48e-04	824	70	8	20237496
Pubmed	Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein.	SPARC ACLY	2.60e-04	12	70	2	8070621
Pubmed	Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation.	SIX4 SIX1	2.60e-04	12	70	2	22987639
Pubmed	Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.	SIX1 SIX2	3.07e-04	13	70	2	30905259
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	SFMBT1 ACLY KTN1 BMS1 SIX5 SIX4 SIX1 XPO7	3.23e-04	857	70	8	25609649
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	VIM NAMPT ACLY USP9X BMS1 TFB2M XPO7	3.56e-04	657	70	7	36180527
Pubmed	Enzymology of NAD+ homeostasis in man.	NAMPT HAAO	3.58e-04	14	70	2	14704851
Pubmed	Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates.	SIX4 SIX1	3.58e-04	14	70	2	24885223
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	VIM SPAG1 MCMBP NAMPT FCGBP USP9X KTN1 BMS1 NGLY1 XPO7	3.95e-04	1367	70	10	32687490
Pubmed	Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1.	SIX4 SIX1	4.12e-04	15	70	2	16530750
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP9X USP1	4.12e-04	15	70	2	9827704
Pubmed	Identification of potential protein interactors of Lrrk2.	VIM LRRK2	4.12e-04	15	70	2	17400507
Pubmed	Muscle contraction is necessary to maintain joint progenitor cell fate.	SIX4 SIX1	4.12e-04	15	70	2	19460349
Interaction	EYA3 interactions	DSCAM SIX5 SIX4 SIX1 SIX2	5.09e-06	73	69	5	int:EYA3
Interaction	ASB15 interactions	VIM ACLY USP9X ZFYVE26	7.63e-06	37	69	4	int:ASB15
GeneFamily	SINE class homeoboxes	SIX5 SIX4 SIX1 SIX2	5.48e-10	6	46	4	525
GeneFamily	Sterile alpha motif domain containing	SFMBT1 SAMD9 INPPL1 SAMHD1	7.31e-05	88	46	4	760
GeneFamily	ATPase phospholipid transporting	ATP8B3 ATP10D	6.51e-04	15	46	2	1210
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE16 ZFYVE26	2.81e-03	31	46	2	81
GeneFamily	WD repeat domain containing	WDR75 IFT80 CFAP57 DENND3	4.36e-03	262	46	4	362
Coexpression	GSE17721_0.5H_VS_8H_GARDIQUIMOD_BMDC_DN	NAMPT GOLPH3L ZFYVE16 TNFSF10 INPPL1 RGS9	1.43e-05	199	69	6	M4142
Coexpression	GSE17580_UNINFECTED_VS_S_MANSONI_INF_TEFF_UP	SLC37A1 MCMBP GUCA1B LRRK2 BLNK HAAO	1.47e-05	200	69	6	M3675
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM LRRK2 BLNK HAAO DENND3	7.63e-06	172	70	5	356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM LRRK2 BLNK HAAO DENND3	7.63e-06	172	70	5	46fadeee483fdf8402df92ec98575a09c6c15b16
ToppCell	facs-Thymus-Flowthrough-3m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSCAM LRRK2 BLNK HAAO DENND3	7.63e-06	172	70	5	438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCell	facs-Skin-Telogen-3m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIM TNFSF10 CD163L1 IRAG2 DENND3	8.52e-06	176	70	5	3d372c1d527fcc118d1e5809f2524fc387682472
ToppCell	facs-Skin-Telogen-3m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIM TNFSF10 CD163L1 IRAG2 DENND3	8.52e-06	176	70	5	7b3f3d9b33770edf294cee0eccaf8a46f9331461
ToppCell	facs-Skin-Telogen-3m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIM TNFSF10 CD163L1 IRAG2 DENND3	8.52e-06	176	70	5	9c0fb2c6ae84febdf7c3d4e648985f597dcffe7a
ToppCell	(5)_Epithelial_cells-(5)_Glands_mucous\|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	VIM FCGBP SIX1 PPM1H MYBPC3	9.51e-06	180	70	5	a4118adaf4b09e2ca01b662ed60e7bbf32a24d58
ToppCell	Control-Lymphoid-B\|World / Disease state, Lineage and Cell class	SFMBT1 NETO1 BLNK IRAG2 NGLY1	9.76e-06	181	70	5	9124f1a610cfc3355ad87921cd3eb5346956475d
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC37A1 NETO1 PLEKHG7 BLNK ATP10D	1.06e-05	184	70	5	d18e94839a62fca536ae1630c154e5d0aafc44c5
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENGASE CD163L1 F8 DENND3 DYRK3	1.09e-05	185	70	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	Influenza_Severe\|World / Disease group and Cell class	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.43e-05	196	70	5	6a8ecb524f55212a91060d45ab8612f3f677e543
ToppCell	Influenza_Severe-Classical_Monocyte\|World / Disease group and Cell class	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.47e-05	197	70	5	e9a01f0fbbeaf6b23bce4603f62053c003848da4
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-classical_monocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.47e-05	197	70	5	94e2cc7ec531e58b8ed7e5601fdf8c4bbc3582c8
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-classical_monocyte-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.51e-05	198	70	5	c79c1738560d78b63dbed5f2f9621dbc1c2363cb
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-classical_monocyte\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.51e-05	198	70	5	1d1c80569f1e307285ba0ebaf5c72e0b5b538864
ToppCell	Influenza_Severe-Classical_Monocyte\|Influenza_Severe / Disease group and Cell class	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.54e-05	199	70	5	077ace6e0faedb8c701fcb227427204678867237
ToppCell	mild-Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	NAMPT GUCA1B TNFSF10 DENND3 ATP10D	1.54e-05	199	70	5	ca319976a7d2576186d0a98cdc93e4c2d5fe8a05
ToppCell	Transverse-T_cell-Tfh\|T_cell / Region, Cell class and subclass	SFMBT1 GOLPH3L AMIGO1 ADGRG6 B4GALT4	1.54e-05	199	70	5	33ffea12b8228e0b5bd8942531c3b21d24224725
ToppCell	severe_influenza-Classical_Monocyte\|World / disease group, cell group and cell class (v2)	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.54e-05	199	70	5	b8adbd6ff5e5602259118a69fd7c77e8348a27e4
ToppCell	severe_influenza-Classical_Monocyte\|severe_influenza / disease group, cell group and cell class (v2)	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.54e-05	199	70	5	899d9fa9e3d97e876da27674de89c33bff1affe9
ToppCell	severe_influenza\|World / disease group, cell group and cell class (v2)	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.58e-05	200	70	5	2c965ec0c33a797c227a06dac90b5ecb959816f6
ToppCell	Influenza-Influenza_Severe-Myeloid\|Influenza_Severe / Disease, condition lineage and cell class	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.58e-05	200	70	5	2bf931ec2c6165698ba600b151fd30d8dd921d95
ToppCell	Sepsis-Leuk-UTI-Myeloid\|Leuk-UTI / Disease, condition lineage and cell class	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.58e-05	200	70	5	175cd0abb24f9f4b9cd5425fede5a8da97d238d0
ToppCell	Influenza-Influenza_Severe-Myeloid-CD14+_Monocyte\|Influenza_Severe / Disease, condition lineage and cell class	VIM NAMPT TNFSF10 LRRK2 SAMHD1	1.58e-05	200	70	5	7add63fb6235ddb928aa9482a1dd9d62638bb3d9
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	ZFYVE16 SIX4 ACVR2B SIX1	8.94e-05	149	70	4	768877bade04ca0321593b8470b5011ad8270431
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	NAALAD2 CD163L1 KNDC1 ADGRG6	1.07e-04	156	70	4	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BLNK HAAO TFIP11 USP1	1.09e-04	157	70	4	6730b775308f45a2f3946016bdbb7f8e5b5efe49
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCA1B ABHD12B RGS9 DNAH1	1.15e-04	159	70	4	00a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIM LRRK2 RGS9 SAMHD1	1.18e-04	160	70	4	8dae9b0cf90a09acb196223f45a14680102630b2
ToppCell	facs-Thymus-Epithelium-3m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP KNDC1 SIX4 SIX1	1.23e-04	162	70	4	3dc39db0d5f6f3d7bcc312a6bce7aaeb914138d1
ToppCell	facs-Thymus-Epithelium-3m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP KNDC1 SIX4 SIX1	1.23e-04	162	70	4	0a7138266054ea5954649c8b61ef93905d56b068
ToppCell	facs-Thymus-Epithelium-3m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP KNDC1 SIX4 SIX1	1.23e-04	162	70	4	25323785dd33337bcefd05958a4a1a208a9ceb04
ToppCell	normal_Lymph_Node-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	WDR75 TNFSF10 SAMHD1 MYBPC3	1.39e-04	167	70	4	820472887f43b42ae7e44513ca3d5465fb4f71a7
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLEKHG7 IRAG2 PPM1H ADGRG6	1.42e-04	168	70	4	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PLEKHG7 SIX5 CFAP57 DNAH1	1.42e-04	168	70	4	9a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNFSF10 LRRK2 RGS9 ADGRG6	1.45e-04	169	70	4	8f397cf4f9fd7c6fa88d01a95289ce2a6bc6938d
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	1.49e-04	170	70	4	1f994b690e881106a5d54b3080ccce6260bc3ac5
ToppCell	droplet-Lung-21m-Epithelial-airway_epithelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FCGBP KNDC1 CFAP57 SIX1	1.59e-04	173	70	4	a809be2630d2b91b53b82b5e2bb99e05524597c1
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP IRAG2 HAAO DYRK3	1.59e-04	173	70	4	7c5e4809205ce1a0a301c15442af00a2e2b9b301
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC37A1 SPAG1 CD163L1 HAAO	1.62e-04	174	70	4	6987fe7959afce347282f632abc16d800ccab7c4
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 BLNK HAAO SAMHD1	1.62e-04	174	70	4	2f4bc0275cbcaa830d04a4c76e042456908d2277
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 BLNK HAAO SAMHD1	1.62e-04	174	70	4	01eff218e71a04201189a0313aaf91437fffed95
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Myeloid-macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 BLNK HAAO SAMHD1	1.62e-04	174	70	4	f0f6d135e1fb4c15022be103b00d8d5456515a18
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNFSF10 LRRK2 RGS9 ADGRG6	1.70e-04	176	70	4	33323c97afe509147956b8df9f92ca6b0537e604
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Neutrophil\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NAMPT ABHD12B DENND3 MYBPC3	1.70e-04	176	70	4	676839d07450b313222622e0ffd305c732cbad6d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SPARC DSCAM ABHD12B F8	1.70e-04	176	70	4	64e426f5e84884ce2c29acf6f4b958962a63927f
ToppCell	Severe-CD4+_T_activated\|Severe / Disease group and Cell class	SAMD9 TNFSF10 PLEKHG7 SAMHD1	1.73e-04	177	70	4	a08f170f1143fcdd7d0842a54d9b807a4548f8b7
ToppCell	Fetal_29-31_weeks-Epithelial-lung_goblet_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FCGBP TNFSF10 SIX1 PPM1H	1.73e-04	177	70	4	a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCell	Fetal_29-31_weeks-Epithelial-lung_goblet_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FCGBP TNFSF10 SIX1 PPM1H	1.73e-04	177	70	4	363e07b0f347f3716d530a28ead854b98e27d37c
ToppCell	Severe-CD4+_T_activated\|World / Disease group and Cell class	SAMD9 TNFSF10 PLEKHG7 SAMHD1	1.77e-04	178	70	4	ef6111238703579a34bd6948bd9d4ca6b7e16063
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLEKHG7 IRAG2 CFAP57 ADGRG6	1.81e-04	179	70	4	906555ce2ca264a0215b120c7ff7c9b411de6a34
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KTN1 LRRK2 F8 DENND3	1.85e-04	180	70	4	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KTN1 LRRK2 F8 DENND3	1.85e-04	180	70	4	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NETO1 PLEKHG7 BLNK ATP10D	1.93e-04	182	70	4	ccd729388d997cc45071175cb0c3db6d0790eaf8
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SAMD9 TNFSF10 USP9X SAMHD1	1.97e-04	183	70	4	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	Epithelial-lung_goblet_cell\|World / Lineage, Cell type, age group and donor	FCGBP TNFSF10 PLEKHG7 SIX1	1.97e-04	183	70	4	940cbe298e9c53b5622af09264586ed823d3141f
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a7-Slc17a8.Fezf2-Slc17a8_(Layer_5,_Retrosplenial_cortex_(RSG)_and_Subiculum,_Tshz2+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ATP8B3 HAAO ACVR2B	1.99e-04	72	70	3	e3f4d1df43cc41b0424f27485a00ddca9e905f95
ToppCell	Control-Lymphoid-B\|Control / Disease state, Lineage and Cell class	SFMBT1 NETO1 BLNK IRAG2	2.01e-04	184	70	4	de0294f879268bfd68e91adcc2adba211d221b7a
ToppCell	P28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NAALAD2 SPARC DIPK2A ADGRG6	2.01e-04	184	70	4	23c24ab5786af33d605bc445d06117b9da6c6331
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAMD9 TNFSF10 LRRK2 SAMHD1	2.05e-04	185	70	4	f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	SFMBT1 PLEKHG7 BLNK NGLY1	2.05e-04	185	70	4	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VIM SPARC SAMHD1 ADGRG6	2.05e-04	185	70	4	dd17025d8c423aa0a451ac7f1f301c93528e0229
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NAMPT TNFSF10 LRRK2 PPM1H	2.10e-04	186	70	4	3dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B KTN1 TFIP11 F8	2.10e-04	186	70	4	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B KTN1 TFIP11 F8	2.10e-04	186	70	4	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF13B KTN1 TFIP11 F8	2.10e-04	186	70	4	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPARC TNFSF10 F8 DENND3	2.18e-04	188	70	4	0aa8747c2931b0c91f6d78bb2db8fd8ede6dd559
ToppCell	LAM-Endothelial-VasEndo-1\|Endothelial / Condition, Lineage and Cell class	VIM SPARC TNFSF10 RGS9	2.18e-04	188	70	4	f24c33d960ca93459584a79ff8f0ec20db6a34d5
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.18e-04	188	70	4	a906c29e3fda22eecfec3e5cac706c417bf2b7a4
ToppCell	P28-Mesenchymal-developing_mesenchymal_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NAALAD2 SPARC DIPK2A ADGRG6	2.18e-04	188	70	4	e7681efb4d2de7f1d8a89552fff76a829376bf1b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NAMPT TNFSF10 LRRK2 PPM1H	2.23e-04	189	70	4	1ecf9911ff82e0ca0f0c101b735d3b1f3b339d57
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-classical_monocyte-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NAMPT TNFSF10 LRRK2 SAMHD1	2.23e-04	189	70	4	cce6602ad68c177985a5e43cfb2776d615cfbca0
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.23e-04	189	70	4	ca3a04c202afc32aa11d17154066ef7dc6d01405
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPARC TNFSF10 F8 DENND3	2.27e-04	190	70	4	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.27e-04	190	70	4	7e4d80a3a7f83b6a50f1d0fe82fb6c242c39d5b0
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.27e-04	190	70	4	1004e89d99c9d46c78b7d3532d8d4aadb81a96fd
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.27e-04	190	70	4	106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPARC TNFSF10 F8 DENND3	2.27e-04	190	70	4	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.27e-04	190	70	4	951e067d14412db67dc3babcdf61e41717d7b429
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.27e-04	190	70	4	10b02c62e72bfea9767e3e751011436925da823e
ToppCell	B_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PLEKHG7 BLNK IRAG2 DENND3	2.32e-04	191	70	4	72e3191990973440e4f91427208df360f73e4f41
ToppCell	proximal-Hematologic-Platelet/Megakaryocyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF527 PLEKHG7 SIX4 PPM1H	2.36e-04	192	70	4	522d1bb15edf1d6006b80289bd3baadb99584ae8
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.36e-04	192	70	4	430ef714bf2544d32f3fd96a55af010f79aa9be0
ToppCell	proximal-3-Hematologic-Platelet/Megakaryocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF527 PLEKHG7 SIX4 PPM1H	2.36e-04	192	70	4	f5f83dec37dff32a0c471cb05d23d13b0b0ad0c9
ToppCell	Ciliated-cil-3\|World / Class top	KNDC1 CFAP57 DYRK3 DNAH1	2.36e-04	192	70	4	4989ebb8812b8af1870599acd932849122c05a29
ToppCell	proximal-Hematologic-Platelet/Megakaryocyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZNF527 PLEKHG7 SIX4 PPM1H	2.36e-04	192	70	4	57899a905ca3e336bb7f31edc6418a2546b9891a
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.36e-04	192	70	4	158cc5736f154da1cb3186ffbf186eae10483e48
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.36e-04	192	70	4	f4ff62ac9c53eafbe917706de9af8b2d4bded4d4
ToppCell	PCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_neutrophils_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CD163L1 LRRK2 IRAG2 SAMHD1	2.41e-04	193	70	4	c9e3fefa8d68d0e2b954f85ce37813185ff98d84
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF13B VIM ABHD12B ADGRG6	2.41e-04	193	70	4	d5930f7bd9b299f792212d40a3272a37adf64a82
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP GOLPH3L ACLY IRAG2	2.41e-04	193	70	4	5a92697430f16c49e19a5f727d289d7bd1ece31c
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP GOLPH3L ACLY IRAG2	2.41e-04	193	70	4	64bcdbb422f8da6fc3275e82f6aaf562f546a180
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.41e-04	193	70	4	7386fadc13a437f3b0c99b5d116cd3c5f893529c
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SAMD9 IRAG2 LYAR F8	2.46e-04	194	70	4	6be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAALAD2 SPARC DIPK2A ADGRG6	2.46e-04	194	70	4	6a4e7f1bf67bad94cd8c472e7c66798b0c25ba01
ToppCell	control-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRK2 BLNK IRAG2 DENND3	2.46e-04	194	70	4	a5284adca931a78b1c4592925c4860853ebd24f1
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VIM TNFSF10 LRRK2 ADGRG6	2.46e-04	194	70	4	70185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	VIM NAMPT LRRK2 DENND3	2.46e-04	194	70	4	607b5d194ba56efa9b106f10f89368fc103712a0
ToppCell	COVID_vent-Myeloid-Monocytic-Neutrophil\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NAMPT TNFSF10 LRRK2 DENND3	2.46e-04	194	70	4	eb23b171e429165dd26a64377eae7fa2ce25f547
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	FCGBP CD163L1 IRAG2 ADGRG6	2.46e-04	194	70	4	58046894446cb250814252a23f60fdd59c114d77
Disease	branchiootorenal syndrome (implicated_via_orthology)	SIX5 SIX4 SIX1	4.07e-07	7	68	3	DOID:14702 (implicated_via_orthology)
Disease	Branchiootorenal Spectrum Disorders	SIX5 SIX1	1.57e-05	3	68	2	cv:CN043574
Disease	Branchio-Oto-Renal Syndrome	SIX5 SIX1	3.13e-05	4	68	2	C0265234
Disease	carbon monoxide exhalation measurement	SIX4 SIX1	3.13e-05	4	68	2	EFO_0006520
Disease	Branchio-Oculo-Facial Syndrome	SIX5 SIX1	3.13e-05	4	68	2	C0376524
Disease	Branchiootorenal Syndrome 2	SIX5 SIX1	3.13e-05	4	68	2	C1970479
Disease	Branchiootorenal Syndrome 1	SIX5 SIX1	3.13e-05	4	68	2	C4551702
Disease	myotonic dystrophy type 1 (implicated_via_orthology)	SIX5 SIX4	7.80e-05	6	68	2	DOID:11722 (implicated_via_orthology)
Disease	Down syndrome (implicated_via_orthology)	DSCAM DYRK3	5.39e-04	15	68	2	DOID:14250 (implicated_via_orthology)
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	TYW1B TNFSF10 USP1 DNAH1	1.19e-03	200	68	4	EFO_0004611, EFO_0020945
Disease	Liver Cirrhosis, Experimental	VIM SPARC ZFYVE16 INPPL1 KTN1 ATP10D DIPK2A	2.01e-03	774	68	7	C0023893
Disease	Bilateral Wilms Tumor	SIX1 SIX2	2.04e-03	29	68	2	C2930471

Protein segments in the cluster

Peptide	Gene	Start	Entry
SFLNCGEYKERAWEA	AMIGO1	266	Q86WK6
GDTMDVLFEKWFYCK	HAAO	121	P46952
VGYLEALKEENWDCF	B4GALT4	176	O60513
KESYGKEKGDEFCWI	ADGRG6	1001	Q86SQ4
EDAKGKDCCWYEAAL	ABHD12B	121	Q7Z5M8
FVGCLEWNDKKYSLD	ATP8B3	316	O60423
NESALWDCTYDGKAK	CD163L1	441	Q9NR16
PETFKDFYNCWKETE	DENND3	686	A2RUS2
DCFVTGKWEDDKDAA	BMS1	756	Q14692
KYIDRCWKDVTVGDF	ATP10D	166	Q9P241
EKYSIEPSWECKFDH	NETO1	86	Q8TDF5
FWEACEDLKYGDQSK	RGS9	331	O75916
LKWGAKEVEDHYCDA	NGLY1	271	Q96IV0
AAEDGCLFTWKVFDK	CFAP57	656	Q96MR6
KEALAAFLGWFDYCD	FHIP2B	336	Q86V87
EGEEDKLFWLEACYK	LRRK2	341	Q5S007
YGEWLHGFEKKAKEC	KTN1	1091	Q86UP2
KDEFDCKAWAYFSDV	F8	1846	P00451
CKAWAYFSDVDLEKD	F8	1851	P00451
KGELHKYCTAWDEAD	SLC37A1	46	P57057
KWCEVGVLDYDEEKK	DNAH1	301	Q9P2D7
DLILSAGEDCKYKVW	IFT80	201	Q9P2H3
WYAGACDRKSAEEAL	BLNK	346	Q8WV28
FASSWKLDDGDYLCE	FCGBP	636	Q9Y6R7
WDVWYESKFDDCDKE	DIPK2A	326	Q8NDZ4
GLKDKEGYTSFWNDC	GOLPH3L	56	Q9H4A5
WGDDYKNHVKCISED	LYAR	41	Q9NX58
YSWADAEEEKCELKT	IRAG2	426	Q12912
GAISEKFCDLYWDEK	KNDC1	936	Q76NI1
FAPGWVYECLEKKDF	ENGASE	361	Q8NFI3
KDWGTALKGCDDYLF	DYRK3	481	O43781
DWDCFKVNDILELYG	MCMBP	246	Q9BTE3
TGYDIECKNKSDSWD	DSCAM	916	O60469
CFWSMDESVKEKYAG	KIF13B	61	Q9NQT8
RWYKFDDGDVTECKM	USP9X	1896	Q93008
NGIDVDKWDYFARDC	SAMHD1	306	Q9Y3Z3
DDFWSLKLCRPSKDY	MKLN1	616	Q9UL63
WIFCNGRLDLDSEKY	SAMD9	491	Q5K651
WTFKIYDKDGNGCID	GUCA1B	96	Q9UMX6
YEWISIDKDEAGAKS	INPPL1	886	O15357
WDGEETVYCFKEKSR	SIX4	221	Q9UIU6
KTIWDGEETVYCFKE	SIX5	196	Q8N196
EDPSAAEAVECWKKY	SHCBP1L	326	Q9BZQ2
SKKAYRDVAWLGECD	SIRT2	311	Q8IXJ6
IWDGEETSYCFKEKS	SIX1	121	Q15475
KDCAYKWLYDETLED	TFB2M	381	Q9H5Q4
YDIYNACEKIWGEDL	NAMPT	281	P43490
VDATADYICKVKWGD	ACLY	221	P53396
ELVKKGCWLDDFNCY	ACVR2B	71	Q13705
DWLGVRDKCFYFSDD	CLEC2A	61	Q6UVW9
TGWAYKTIEDEDLKF	PPM1H	356	Q9ULR3
KDGYFKVWILTDDSD	WDR75	466	Q8IWA0
DNDKYIALDEWAGCF	SPARC	276	P09486
SDKAAGLDLPKCWDY	nan	21	Q6ZSR6
RDYAEWDKFDVEKEC	SPAG1	156	Q07617
EAEEWYKSKFADLSE	VIM	286	P08670
ESKYWKEECFGLTAE	PRPF38A	31	Q8NAV1
LGEKWYECDNSGKAF	ZNF705EP	251	A8MWA4
IWDGEETSYCFKEKS	SIX2	121	Q9NPC8
TKLGWFDCQKDDYVF	XPO7	116	Q9UIA9
FYGLKDKTWDEVLET	PLEKHG7	261	Q6ZR37
FDWADYLKQCGAEAA	SFMBT1	356	Q9UHJ3
KDFNCWESLGEAYLS	TTC37	596	Q6PGP7
TCEECGKDFKWYLIF	ZNF732	196	B4DXR9
KSGIACFLKEDDSYW	TNFSF10	51	P50591
ACDKEGWQYLFPVKD	ZFYVE26	1456	Q68DK2
FKEWDPLKDCTYGTE	TFIP11	436	Q9UBB9
CKWLEEASIDFRFGK	TYW1B	106	Q6NUM6
KEYEGKWLLFDDSEV	USP1	741	O94782
YVDICWVDAEEKGNK	ZFYVE16	1381	Q7Z3T8
LECSSFREAWKYKGE	ZNF527	121	Q8NB42
DGFESKSLYESWLEK	NAALAD2	476	Q9Y3Q0
GDSDEWVFDKKLLCE	MYBPC3	706	Q14896