Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

3.05e-085303GO:0030156
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 RIMBP3C RIMBP2 RIMBP3B

2.07e-0736304GO:0007274
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

8.53e-0628303GO:0002177
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

RIMBP2 CTNND1

4.94e-0423302GO:0098831
GeneOntologyCellularComponentcatenin complex

CTNND1 CDH8

9.61e-0432302GO:0016342
GeneOntologyCellularComponentsynaptic cleft

EGFLAM CDH8

1.02e-0333302GO:0043083
GeneOntologyCellularComponentpresynaptic active zone

RIMBP2 EGFLAM CTNND1

1.07e-03141303GO:0048786
GeneOntologyCellularComponentdendrite

PCSK5 KCNQ3 EEF2K RBM8A JPH4 CTNND1

1.20e-03858306GO:0030425
GeneOntologyCellularComponentdendritic tree

PCSK5 KCNQ3 EEF2K RBM8A JPH4 CTNND1

1.21e-03860306GO:0097447
GeneOntologyCellularComponentcell cortex

RIMBP2 HAX1 ACTN3 CTNND1

1.86e-03371304GO:0005938
GeneOntologyCellularComponentcell cortex region

RIMBP2 CTNND1

1.90e-0345302GO:0099738
HumanPhenoFacial capillary hemangioma

RBM8A RECQL4

1.18e-041182HP:0000996
HumanPhenoRadial deviation of the hand

RBM8A RECQL4

1.41e-041282HP:0009486
HumanPhenoMetaphyseal sclerosis

DNAJC21 RECQL4

1.41e-041282HP:0004979
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

6.10e-0619273MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

8.35e-0621273MP:0008893
MousePhenodetached acrosome

RIMBP3 RIMBP3C RIMBP3B

8.07e-0544273MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C RIMBP3B

8.64e-0545273MP:0009376
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

1.66e-0456273MP:0009237
MousePhenoabnormal sperm nucleus morphology

RIMBP3 RIMBP3C RIMBP3B

3.80e-0474273MP:0009232
DomainSH3_9

RIMBP3 RIMBP3C RIMBP2 RIMBP3B

6.17e-0678294PF14604
DomainSH3_2

RIMBP3 RIMBP3C RIMBP2 RIMBP3B

9.11e-0686294IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP2 RIMBP3B

9.11e-0686294PF07653
DomainFN3

RIMBP3 RIMBP3C RIMBP2 EGFLAM RIMBP3B

1.26e-05199295PS50853
DomainFN3_dom

RIMBP3 RIMBP3C RIMBP2 EGFLAM RIMBP3B

1.60e-05209295IPR003961
DomainFN3

RIMBP3C RIMBP2 EGFLAM RIMBP3B

1.82e-04185294SM00060
DomainSH3

RIMBP3 RIMBP3C RIMBP2 RIMBP3B

3.29e-04216294PS50002
DomainSH3

RIMBP3 RIMBP3C RIMBP2 RIMBP3B

3.29e-04216294SM00326
DomainSH3_domain

RIMBP3 RIMBP3C RIMBP2 RIMBP3B

3.53e-04220294IPR001452
DomainHMG_box

PBRM1 SOX13

3.05e-0353292PF00505
DomainHMG_BOX_2

PBRM1 SOX13

3.17e-0354292PS50118
DomainHMG

PBRM1 SOX13

3.17e-0354292SM00398
Domain-

RIMBP3 RIMBP3C RIMBP2 EGFLAM RIMBP3B

3.25e-036632952.60.40.10
Domain-

PBRM1 SOX13

3.29e-03552921.10.30.10
DomainIg-like_fold

RIMBP3 RIMBP3C RIMBP2 EGFLAM RIMBP3B

4.25e-03706295IPR013783
DomainHMG_box_dom

PBRM1 SOX13

4.56e-0365292IPR009071
PathwayREACTOME_CDH11_HOMOTYPIC_AND_HETEROTYPIC_INTERACTIONS

CTNND1 CDH8

4.86e-057222M48038
PathwayREACTOME_REGULATION_OF_CDH11_FUNCTION

CTNND1 CDH8

1.27e-0411222M48015
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP2 RIMBP3B

2.25e-12530417855024
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

2.32e-09430319091768
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

2.09e-071430317662146
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

RTF1 RIMBP2 RBM8A PBRM1 L3MBTL2 TSR1

1.33e-0641730636537216
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

RTF1 DNAJC21 CTNND1 ZC3H4 ETF1 SAP30BP

3.67e-0649730636774506
Pubmed

Biological insights from 108 schizophrenia-associated genetic loci.

PBRM1 CTNND1 L3MBTL2 TSR1 ETF1

5.79e-0630330525056061
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

RTF1 SPAG9 ARHGEF10 ZC3H4

4.10e-0522530412168954
Pubmed

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.

RBM8A ETF1

6.50e-051430216452507
Pubmed

Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.

RIMBP2 SPAG9

6.50e-051430216112646
Pubmed

Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.

KCNQ3 RIMBP2 SPAG9 HAX1 CRACR2A TSR1

6.69e-0583230636724073
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

RBM8A HAX1 PBRM1 CTNND1 TSR1 ZC3H4

7.38e-0584730635850772
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

RIMBP2 CTNND1 ARHGEF10

9.94e-051043039205841
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

RTF1 RBM8A HAX1 CTNND1 ZC3H4 SAP30BP

1.09e-0491030636736316
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

SPAG9 CTNND1 L3MBTL2 ZC3H4 ETF1 SAP30BP

1.26e-0493430633916271
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

RBM8A HAX1 ACTN3 PBRM1 CTNND1 TSR1 SAP30BP

1.34e-04137130736244648
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

RTF1 RBM8A HAX1 CTNND1 TSR1 ZC3H4 ETF1

1.62e-04141530728515276
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

RTF1 CTNND1 TSR1 ZC3H4 ETF1 SAP30BP

1.72e-0498930636424410
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

RBM8A PBRM1 SOX13 SAP30BP

1.80e-0433030433301849
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

RBM8A PBRM1 CTNND1 TSR1

1.84e-0433230425693804
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

RTF1 RBM8A PBRM1 CTNND1 TSR1 ETF1

1.97e-04101430632416067
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PCSK5 DNAJC21 TSR1 ZC3H4 RECQL4

2.17e-0465030538777146
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DNAJC21 EEF2K HAX1 CTNND1 L3MBTL2 ARHGEF10 TSR1

2.20e-04148730733957083
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

EEF2K HAX1 CTNND1 L3MBTL2 SOX13 ETF1

2.24e-04103830626673895
Pubmed

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.

RTF1 ZC3H4 SAP30BP

3.29e-0415630337108203
Pubmed

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.

TSR1 RECQL4

3.29e-043130232355176
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

SPAG9 PBRM1 L3MBTL2 TSR1 ZC3H4 RECQL4

3.97e-04115530620360068
Pubmed

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.

PBRM1 L3MBTL2

6.06e-044230235705031
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

DNAJC21 RBM8A CTNND1 TSR1 ETF1 SAP30BP

6.21e-04125730636526897
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

RTF1 DNAJC21 CTNND1 ZC3H4

6.94e-0447230438943005
Pubmed

Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.

SPAG9 HAX1 CTNND1

6.98e-0420230329540532
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

PBRM1 ETF1 SAP30BP

7.08e-0420330322083510
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

SPAG9 CTNND1 L3MBTL2 P3H4 RECQL4

7.67e-0485730525609649
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

PBRM1 TSR1 ZC3H4 RECQL4

7.74e-0448630430940648
Pubmed

UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.

RBM8A TSR1 RECQL4 SAP30BP

8.04e-0449130436273042
InteractionFBXO22 interactions

RTF1 DNAJC21 CTNND1 ZC3H4 RECQL4 ETF1 SAP30BP

8.92e-06540297int:FBXO22
InteractionRAD18 interactions

RBM8A JPH4 CTNND1 ZC3H4 RECQL4 SAP30BP

4.01e-05457296int:RAD18
InteractionPSMA1 interactions

SPAG9 RBM8A HAX1 UBXN11 RECQL4 ETF1

5.28e-05480296int:PSMA1
InteractionDNAJB1 interactions

HAX1 L3MBTL2 ARHGEF10 RECQL4 ETF1

5.97e-05297295int:DNAJB1
InteractionPLEKHG7 interactions

HAX1 CTNND1 ARHGEF10 RECQL4

6.06e-05150294int:PLEKHG7
InteractionKAT6A interactions

RTF1 RIMBP2 RBM8A PBRM1 L3MBTL2 TSR1

7.38e-05510296int:KAT6A
InteractionPOLR1C interactions

RIMBP3 RIMBP3C CRACR2A TSR1 RECQL4

7.42e-05311295int:POLR1C
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

5.33e-0511130322q11.21
Cytoband17p13.3

TSR1 LIAT1

1.53e-038830217p13.3
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 RIMBP3C RIMBP3B

2.55e-03419303chr22q11
CytobandEnsembl 112 genes in cytogenetic band chr5p13

DNAJC21 EGFLAM

3.75e-03139302chr5p13
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RIMBP3 RIMBP3C RIMBP3B SOX13

5.99e-0617830439889db130216655a34796e7030ffeb372465500
Diseasenon-high density lipoprotein cholesterol measurement

PCSK5 HAX1 PBRM1 ZC3H4 P3H4

4.22e-04713275EFO_0005689
Diseasebody fat distribution

PCSK5 PBRM1 ZC3H4

8.19e-04202273EFO_0004341
DiseaseAlzheimer's disease biomarker measurement

PCSK5 ARHGEF10

8.86e-0448272EFO_0006514
Diseasenon-alcoholic fatty liver disease, cirrhosis of liver

PCSK5 CRACR2A

1.08e-0353272EFO_0001422, EFO_0003095
Diseaserisk-taking behaviour

PBRM1 TSR1 CDH8 ETF1

4.87e-03764274EFO_0008579
DiseaseCCL2 measurement

CRACR2A ZC3H4

5.92e-03126272EFO_0004749
Diseasemosquito bite reaction itch intensity measurement

RTF1 SOX13

6.20e-03129272EFO_0008377
Diseaseautism spectrum disorder (implicated_via_orthology)

CTNND1 ARHGEF10

8.50e-03152272DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PDEMIYDDVENGDEG

ARHGEF10

251

O15013
YITDMGAGEDDEGFE

EGFLAM

251

Q63HQ2
YLSRGDEDLGDMGED

CRACR2A

141

Q9BSW2
GGEDFAMDEDGDESI

RBM8A

11

Q9Y5S9
MDEDGFYEGELDDGR

RIMBP3B

871

A6NNM3
MDEDGFYEGELDDGR

RIMBP3C

871

A6NJZ7
EGYIDFRMGDEGGES

SPAG9

1276

O60271
FAELEGGDDDIEEMG

PBRM1

1316

Q86U86
DPFFGGMTRDEDDDE

HAX1

21

O00165
MEEEEDDDLELFGGY

L3MBTL2

16

Q969R5
MAEDRGYGNDFPIED

KCNQ3

496

O43525
AEELAGYEAEDEAGM

JPH4

506

Q96JJ6
DEDDDDDIVYMGQDG

PCSK5

1816

Q92824
MEARYEKEFGDGSDE

DNAJC21

271

Q5F1R6
DEGGEYDGMQDEPRY

EEF2K

651

O00418
RYDDEGGGEEDTEAF

CDH8

666

P55286
GLEDDQRSMGYDDLD

CTNND1

281

O60716
EEFHDGYGEDLMGDE

RTF1

176

Q92541
GYGEDLMGDEEDRAR

RTF1

181

Q92541
MDEDGFYEGELLDGQ

RIMBP2

206

O15034
MGYKDNDGEEEEREG

LIAT1

46

Q6ZQX7
MDEDGFYEGELEDGR

RIMBP3

871

Q9UFD9
RYFEEEEGQEPGGME

RECQL4

1106

O94761
GGGGEYMEQEEDWDR

ACTN3

21

Q08043
GEMYRYSEDEDSEGE

SOX13

596

Q9UN79
QSGGEGDEYEYDDME

TSR1

411

Q2NL82
AEFEGEGDYEEGMYA

P3H4

401

Q92791
FSRLGGDEDGYEEEE

SAP30BP

51

Q9UHR5
YGEYEGDEEEDMGKE

ZC3H4

201

Q9UPT8
GDEEEDMGKEDYDDF

ZC3H4

206

Q9UPT8
YGESEEPMGDDDYDE

ZC3H4

291

Q9UPT8
YGDEDEVDMLSDGCG

UBXN11

31

Q5T124
GMEYQGGDDEFFDLD

ETF1

421

P62495