Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

9.17e-099604GO:0015379
GeneOntologyMolecularFunctionammonium channel activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

3.58e-0812604GO:0008519
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.25e-0723604GO:0015377
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.05e-0626604GO:0015296
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

4.52e-04119604GO:0015294
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

5.44e-04125604GO:0015108
GeneOntologyMolecularFunctionsymporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.08e-03150604GO:0015293
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.10e-03151604GO:0008509
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

AASS MTHFD2L

1.32e-0318602GO:0016646
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.60e-03167604GO:0015079
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.74e-03171604GO:0015103
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC12A6 SLC12A4 NDUFA9 SLC12A7 SLC12A5

2.09e-03301605GO:0022853
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH group of donors

AASS MTHFD2L

3.66e-0330602GO:0016645
GeneOntologyMolecularFunctionspectrin binding

NPHS1 ANK2

4.68e-0334602GO:0030507
GeneOntologyMolecularFunctionchannel activity

SLC12A6 SLC12A4 TMC6 CACNA1I SLC12A7 SLC12A5

4.84e-03525606GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

SLC12A6 SLC12A4 TMC6 CACNA1I SLC12A7 SLC12A5

4.88e-03526606GO:0022803
GeneOntologyMolecularFunctioncytoskeletal motor activity

CENPE MYO6 KIF13A

5.39e-03118603GO:0003774
GeneOntologyBiologicalProcessammonium transmembrane transport

SLC12A6 SLC12A4 SLC12A7 SLC12A5

3.95e-0813584GO:0072488
GeneOntologyBiologicalProcessammonium import across plasma membrane

SLC12A6 SLC12A4 SLC12A7

8.42e-084583GO:0140157
GeneOntologyBiologicalProcesschloride ion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.81e-0725584GO:0055064
GeneOntologyBiologicalProcessmonoatomic anion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.10e-0628584GO:0055081
GeneOntologyBiologicalProcesspotassium ion homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

3.47e-0637584GO:0055075
GeneOntologyBiologicalProcesscell volume homeostasis

SLC12A6 SLC12A4 SLC12A7 SLC12A5

5.82e-0642584GO:0006884
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.27e-0551584GO:1990573
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

SLC12A6 SLC12A4 CACNA1I SLC12A7 SLC12A5

4.92e-05142585GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

SLC12A6 SLC12A4 CACNA1I SLC12A7 SLC12A5

4.92e-05142585GO:0098659
GeneOntologyBiologicalProcessneuron development

ABLIM1 DPYSL3 KANK1 MYO6 SPHK1 EIF2AK4 TSC22D4 PBX1 PBX2 TNXB TOP2B SLC12A5 WDR47

1.69e-0414635813GO:0048666
GeneOntologyBiologicalProcessimport into cell

SLC12A6 TGM2 ANK2 SLC12A4 LMBR1L MYO6 SPHK1 RIN2 CACNA1I SLC12A7 SLC12A5

1.73e-0410745811GO:0098657
GeneOntologyBiologicalProcesschloride transmembrane transport

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.79e-04112584GO:1902476
DomainKCL_cotranspt

SLC12A6 SLC12A4 SLC12A7 SLC12A5

8.98e-114594IPR000076
DomainSLC12A_fam

SLC12A6 SLC12A4 SLC12A7 SLC12A5

3.12e-097594IPR004842
DomainSLC12_C

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.23e-098594IPR018491
DomainSLC12

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.23e-098594PF03522
DomainAA-permease/SLC12A_dom

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.30e-0722594IPR004841
DomainAA_permease

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.30e-0722594PF00324
DomainKCC1

SLC12A6 SLC12A4

9.81e-062592IPR000622
DomainPBC

PBX1 PBX2

5.86e-054592PF03792
DomainPBX

PBX1 PBX2

5.86e-054592IPR005542
DomainTPR-like_helical_dom

TTC7A ATR TTC28 TRAPPC10

6.28e-03233594IPR011990
DomainKinesin_motor_CS

CENPE KIF13A

7.43e-0341592IPR019821
DomainKinesin-like_fam

CENPE KIF13A

8.15e-0343592IPR027640
DomainKINESIN_MOTOR_1

CENPE KIF13A

8.52e-0344592PS00411
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.87e-097444M27339
PathwayREACTOME_CATION_COUPLED_CHLORIDE_COTRANSPORTERS

SLC12A6 SLC12A4 SLC12A7 SLC12A5

2.87e-097444MM15081
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC12A6 SLC12A4 SLC12A7 SLC12A5

3.49e-04108444M823
PathwayREACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES

SLC12A6 SLC12A4 SLC12A7 SLC12A5

3.62e-04109444MM15074
Pubmed

Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

9.15e-12462412637262
Pubmed

Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.37e-10862411395011
Pubmed

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.37e-10862424393035
Pubmed

Similar effects of all WNK3 variants on SLC12 cotransporters.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.37e-10862421613606
Pubmed

Cation-chloride cotransporters and neuronal function.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.15e-09962419323993
Pubmed

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.

SLC12A6 SLC12A4 SLC12A7

5.39e-09362311551954
Pubmed

Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.

SLC12A6 SLC12A4 SLC12A7

5.39e-09362315262997
Pubmed

K-Cl cotransporter gene expression during human and murine erythroid differentiation.

SLC12A6 SLC12A4 SLC12A7

5.39e-09362321733850
Pubmed

Rare independent mutations in renal salt handling genes contribute to blood pressure variation.

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.54e-082262418391953
Pubmed

Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).

SLC12A6 SLC12A4 SLC12A7

3.00e-07862312386165
Pubmed

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.

SLC12A6 SLC12A7 SLC12A5

4.50e-07962314532115
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ABLIM1 KANK1 TTC28 BAZ2A CUL9 BAIAP3 SLC12A5 WDR47

6.39e-0740762812693553
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SLC12A6 ABLIM1 DPYSL3 ANK2 SYN3 MYO6 TRAPPC10 OGDHL DDX3Y TSC22D4 NDUFA9 SLC12A5 WDR47

1.16e-061431621337142655
Pubmed

Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4.

SLC12A7 SLC12A5

3.13e-06262220516068
Pubmed

Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

SLC12A6 SLC12A4

3.13e-06262234031912
Pubmed

Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.

SLC12A7 SLC12A5

3.13e-06262212106695
Pubmed

Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.

PBX1 PBX2

3.13e-0626227910944
Pubmed

SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.

SLC12A6 SLC12A7

3.13e-06262231393094
Pubmed

Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.

SLC12A6 SLC12A4

3.13e-06262217510708
Pubmed

Pbx1 is required for adult subventricular zone neurogenesis.

PBX1 PBX2

3.13e-06262227226325
Pubmed

Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family.

SLC12A6 SLC12A7

3.13e-06262210347194
Pubmed

Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.

SLC12A6 SLC12A4

3.13e-06262231835175
Pubmed

Targeting SPHK1/PBX1 Axis Induced Cell Cycle Arrest in Non-Small Cell Lung Cancer.

SPHK1 PBX1

3.13e-06262236361531
Pubmed

Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca2+/CaM) and CaM Kinase II (CaMKII) Binding Partner.

ACTR1B ABLIM1 ANK2 MYO6 OGDHL TSC22D4

3.81e-0623362629518331
Pubmed

Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.

SLC12A6 SLC12A4

9.37e-06362231352162
Pubmed

The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.

PBX1 PBX2

9.37e-06362215169896
Pubmed

IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.

SLC12A6 SLC12A7

9.37e-06362217133354
Pubmed

Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.

SLC12A6 SLC12A4

9.37e-06362235274823
Pubmed

Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning.

SLC12A6 SLC12A5

9.37e-06362222252133
Pubmed

The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.

PBX1 PBX2

9.37e-06362211468159
Pubmed

Prep1, a novel functional partner of Pbx proteins.

PBX1 PBX2

9.37e-0636229482739
Pubmed

Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.

SLC12A6 SLC12A7

9.37e-06362224089410
Pubmed

Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.

SLC12A4 SLC12A5

9.37e-06362212739168
Pubmed

A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b.

PBX1 PBX2

9.37e-06362210679934
Pubmed

Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters.

SLC12A6 SLC12A7

9.37e-06362212657561
Pubmed

Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.

PBX1 PBX2

9.37e-06362212609849
Pubmed

Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

TTC7A LMBR1L CACNA1I SLC12A5

1.07e-057662410574461
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SLC12A6 ABLIM1 MYO6 RIN2 TMC6 ZG16B EIF2AK4 TSC22D4 PBX1 PBX2 BAIAP3 SH3RF3

1.08e-051489621228611215
Pubmed

PBX1 acts as terminal selector for olfactory bulb dopaminergic neurons.

PBX1 PBX2

1.87e-05462232156753
Pubmed

Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

PBX1 PBX2

1.87e-05462218723445
Pubmed

PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.

PBX1 PBX2

1.87e-0546221682799
Pubmed

Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci.

PBX1 PBX2

1.87e-0546228661110
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ATR MYO6 EIF2AK4 NEURL4 TOP2B

3.11e-0520262533005030
Pubmed

Sites of regulated phosphorylation that control K-Cl cotransporter activity.

SLC12A6 SLC12A5

3.12e-05562219665974
Pubmed

Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.

PBX1 PBX2

3.12e-05562210842069
Pubmed

HOX cofactors expression and regulation in the human ovary.

PBX1 PBX2

3.12e-05562218973687
Pubmed

Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.

PBX1 PBX2

3.12e-05562211335119
Pubmed

HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.

PBX1 PBX2

3.12e-05562210082572
Pubmed

Transcription factor PBX4 regulates limb development and haematopoiesis in mice.

PBX1 PBX2

3.12e-05562238230761
Pubmed

MEIS proteins as partners of the TLX1/HOX11 oncoprotein.

PBX1 PBX2

4.67e-05662219559479
Pubmed

The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse.

PBX1 PBX2

4.67e-05662210381567
Pubmed

A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.

PBX1 PBX2

4.67e-05662237414772
Pubmed

KCC3 loss-of-function contributes to Andermann syndrome by inducing activity-dependent neuromuscular junction defects.

SLC12A6 SLC12A5

4.67e-05662228647557
Pubmed

Characterization of TALE genes expression during the first lineage segregation in mammalian embryos.

PBX1 PBX2

4.67e-05662222987645
Pubmed

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.

TTC7A ACTR1B ABLIM1 DPYSL3 ANK2 MYO6 WDR47

6.04e-0555862735063084
Pubmed

Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon.

PBX1 PBX2

6.53e-05762217178831
Pubmed

Behavioural phenotypes of hypomorphic KCC2-deficient mice.

SLC12A4 SLC12A5

6.53e-05762215813942
Pubmed

PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.

PBX1 PBX2

6.53e-05762212397630
Pubmed

A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.

PBX1 PBX2

6.53e-05762215944191
Pubmed

Purification of the Prep1 interactome identifies novel pathways regulated by Prep1.

PBX1 PBX2

6.53e-05762217623278
Pubmed

GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis.

PBX1 CRTC2

8.69e-05862220541704
Pubmed

Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease.

PBX1 PBX2

8.69e-05862231625560
Pubmed

Bone morphology is regulated modularly by global and regional genetic programs.

PBX1 PBX2

1.12e-04962231221640
Pubmed

A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle.

PBX1 PBX2

1.12e-04962218676817
Pubmed

Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis.

PBX1 PBX2

1.12e-04962212183364
Pubmed

Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation.

PBX1 PBX2

1.12e-04962215087118
Pubmed

A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.

ABLIM1 ANK2 KIF13A

1.12e-045262322219177
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

SLC12A6 ACTR1B DPYSL3 MYO6 DDX3Y NDUFA9 SLC12A5

1.18e-0462162722794259
Pubmed

A protein interaction landscape of breast cancer.

TGM2 TTC28 MYO6 RIN2 ZG16B CUL9 TOP2B

1.34e-0463462734591612
Pubmed

Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.

PBX1 PBX2

1.39e-041062221497760
Pubmed

Hox cofactors in vertebrate development.

PBX1 PBX2

1.39e-041062216515781
Pubmed

Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface.

PBX1 PBX2

1.39e-041062229797482
Pubmed

A unique stylopod patterning mechanism by Shox2-controlled osteogenesis.

PBX1 PBX2

1.39e-041062227287812
Pubmed

Protein Binder Toolbox for Studies of Solute Carrier Transporters.

SLC12A6 SLC12A4 SLC12A7

1.40e-045662338878854
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ABLIM1 DPYSL3 TTC28 AASS TSC22D4 KIF13A SH3RF3 CRTC2

1.42e-0486162836931259
Pubmed

Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion.

PBX1 PBX2

1.70e-041162229437830
Pubmed

Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.

SLC12A6 SLC12A4

2.04e-041262227782176
Pubmed

A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm.

PBX1 PBX2

2.04e-041262234446717
Pubmed

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.

OGDHL SH3RF3

2.04e-041262225438054
Pubmed

Proliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium.

PBX1 PBX2

2.04e-041262220573694
Pubmed

Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.

PBX1 PBX2

2.04e-041262220627960
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

SLC12A4 MYO6 AASS RIN2 TRAPPC10 KIF13A BAIAP3 NEURL4

2.31e-0492562828986522
Pubmed

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.

PBX1 PBX2

2.41e-041362216847320
Pubmed

Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.

PBX1 PBX2

2.41e-041362217049510
Pubmed

Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon.

PBX1 PBX2

2.41e-041362216438966
Pubmed

Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.

TGM2 DSG1 MYO6 PBX2 TOP2B

2.73e-0432162532098917
Pubmed

Control of pelvic girdle development by genes of the Pbx family and Emx2.

PBX1 PBX2

2.81e-041462221455939
Pubmed

Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.

ABLIM1 DDX3Y

2.81e-041462215570572
Pubmed

Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.

PBX1 PBX2

3.23e-041562230071041
Pubmed

Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells.

PBX1 PBX2

3.23e-041562223756022
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

TTC7A ATR RIN2 NDUFA9

3.47e-0418662433637726
Pubmed

Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.

ANK2 SLC12A5

4.70e-041862231910261
Pubmed

Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.

PBX1 PBX2

4.70e-041862226904955
Pubmed

PBX transcription factors drive pulmonary vascular adaptation to birth.

PBX1 PBX2

5.24e-041962229251627
Pubmed

Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.

PBX1 PBX2

6.42e-042162223650387
Pubmed

The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.

PBX1 PBX2

7.06e-042262222748019
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

TTC7A ABLIM1 TTC28 BAIAP3

7.09e-0422562412168954
Pubmed

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.

DPYSL3 ANK2 OGDHL NDUFA9 SLC12A5

7.67e-0440362530562941
Pubmed

Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.

PBX1 PBX2

7.72e-042362230779601
Pubmed

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.

PBX1 PBX2

7.72e-042362216672333
InteractionMS4A15 interactions

SLC12A6 SLC12A4 PCNX3 SLC12A7

5.40e-0639604int:MS4A15
InteractionFAM222A interactions

CUL9 PBX1 PBX2

7.02e-0613603int:FAM222A
InteractionLGALS9B interactions

SLC12A6 SLC12A4 DDX3Y SLC12A7

9.65e-0645604int:LGALS9B
InteractionGPM6A interactions

DPYSL3 ANK2 SYN3 OGDHL SLC12A5 WDR47

1.06e-05168606int:GPM6A
InteractionSLC17A2 interactions

SLC12A6 SLC12A4 PCNX3 SLC12A7

2.32e-0556604int:SLC17A2
InteractionSLC12A5 interactions

SLC12A4 SLC12A7 SLC12A5

3.21e-0521603int:SLC12A5
InteractionZDHHC12 interactions

SLC12A6 SLC12A4 PCNX3 TMC6 SLC12A7

3.26e-05123605int:ZDHHC12
InteractionPOPDC2 interactions

ANK2 PCNX3 SLC12A7

4.26e-0523603int:POPDC2
InteractionLYN interactions

NPHS1 SLC12A6 ABLIM1 ANK2 SLC12A4 DSG1 MYO6 SPHK1 SLC12A7 TOP2B

4.77e-057206010int:LYN
InteractionOR10H2 interactions

SLC12A6 SLC12A4 PCNX3 SLC12A7

6.28e-0572604int:OR10H2
InteractionCLRN2 interactions

SLC12A6 SLC12A4 PCNX3 SLC12A7

7.76e-0576604int:CLRN2
InteractionRGS14 interactions

ACTR1B ABLIM1 ANK2 MYO6 OGDHL TSC22D4

7.84e-05240606int:RGS14
InteractionTMC4 interactions

SLC12A6 SLC12A4 SLC12A7

9.62e-0530603int:TMC4
InteractionPIGH interactions

SLC12A6 SLC12A4 PCNX3 TMC6 SLC12A7

1.17e-04161605int:PIGH
InteractionRAB39A interactions

SLC12A6 EGLN3 LMBR1L

1.28e-0433603int:RAB39A
InteractionRXFP1 interactions

SLC12A6 SLC12A4 PCNX3 SLC12A7

1.50e-0490604int:RXFP1
InteractionLGALS9C interactions

SLC12A6 SLC12A4 SLC12A7

1.53e-0435603int:LGALS9C
GeneFamilyTALE class homeoboxes and pseudogenes

PBX1 PBX2

1.50e-0326402526
GeneFamilyKinesins|Pleckstrin homology domain containing

CENPE KIF13A

4.64e-0346402622
GeneFamilySolute carriers

SLC12A6 SLC12A4 SLC12A7 SLC12A5

1.10e-02395404752
GeneFamilyPHD finger proteins

BAZ2A PHF7

1.69e-029040288
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPYSL3 ANK2 TTC28 AASS PBX1 TNXB

3.08e-07195626ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

DPYSL3 ANK2 TTC28 PBX1 TNXB

5.96e-06185625a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABLIM1 SYN3 SPHK1 RIN2 SH3RF3

6.28e-06187625e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS TMC6 TSC22D4 KIF13A

6.44e-06188625d9692b6048d9b85524a07a1807bdd4757731c151
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TMC6 TSC22D4

6.61e-0618962542ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TMC6 TSC22D4

6.61e-0618962537ecbd73408d462b47d7e5611f203143e08a2689
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TMC6 TSC22D4

6.78e-0619062507f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TMC6 TSC22D4

6.78e-06190625ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TMC6 TSC22D4

6.96e-061916252b056cbe2e82e056e1f798974999378460eb1d16
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TMC6 TSC22D4

6.96e-06191625a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DPYSL3 ANK2 SYN3 PBX1 TNXB

6.96e-061916256688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DPYSL3 ANK2 SYN3 PBX1 TNXB

7.14e-0619262599ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCellControl-PLT_1|World / Disease Group and Platelet Clusters

EGLN3 SPHK1 MYEOV TSC22D4 PBX1

7.14e-06192625f595eba81911eb860dce964f1d8269287f50d3ea
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DPYSL3 ANK2 SYN3 PBX1 TNXB

7.89e-061966257d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellnucseq-Endothelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABLIM1 DPYSL3 SYN3 TTC28 SH3RF3

8.08e-06197625ebf9be068eaa658493fa7884fd19f34642922acb
ToppCell(5)_Fibroblasts-(5)_Fibroblast-D|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

ABLIM1 DPYSL3 ANK2 DDX3Y TNXB

8.28e-06198625fd14efd8e6c74a04bde985c08dc34217c0ef1bab
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DPYSL3 ANK2 SYN3 PBX1 TNXB

8.28e-061986258f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

DPYSL3 ANK2 TTC28 PBX1 TOP2B

8.28e-06198625de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-2,_SCARA5|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

ABLIM1 DPYSL3 ANK2 PBX1 TNXB

8.70e-06200625ef30f9b68bfdb8d947ed399603e4dd0d5ff0144d
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ABLIM1 DPYSL3 ANK2 PBX1 TNXB

8.70e-06200625b28bfe6eb96b4db9cb27f0fc8fc39259c125f05e
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ABLIM1 DPYSL3 ANK2 PBX1 TNXB

8.70e-0620062587953ea65ff2a01485e13dd49d993ae6ae679cbf
ToppCellControl-Fibroblasts-Mesothelial_FB|Control / group, cell type (main and fine annotations)

NPHS1 ANK2 WDR87 ADGRD2

4.23e-05139624e769beb031b262dd92c9605b07dbf3c29fb82520
ToppCellLymphoid-Lymphoid-T_cells_(Cd4+_Tnaive-Tcm)|Lymphoid / shred on cell class and cell subclass (v4)

ABLIM1 LMBR1L MYO6 SLC12A7

6.15e-05153624ffb8ac88513e83d3ba01574e60beb5476154372b
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

LMBR1L SPHK1 DDX3Y PHF7

6.63e-05156624029ba0832ee9c4a2c85620e4df2260e02d86b45c
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Junb_(Mural,_IEG+)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

LMBR1L SPHK1 DDX3Y PHF7

6.63e-051566245df19a235843829f5a1a90ca21b0964ef8b4e115
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EGLN3 KANK1 MTHFD2L SLC12A7

8.64e-05167624f01b96173deda0239fa482989873cf308e49d48c
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EGLN3 KANK1 MTHFD2L SLC12A7

8.64e-051676245fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCellcontrol-Myeloid-pDC|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

EGLN3 KANK1 CCDC168 SH3RF3

8.84e-05168624affc39c7568b7df4b36af6f5b0e3702a18b6268c
ToppCelldroplet-Pancreas-Exocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM2 EGLN3 SPHK1 XDH

9.04e-0516962453690d6f9712b54aa99a0408aae930d64ae478e5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPYSL3 SPHK1 ADGRD2 TNXB

9.25e-051706246035c92cd39c5ac54e7ec57d94888ee19f574639
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPYSL3 SPHK1 ADGRD2 TNXB

9.25e-05170624c8c42eda44b61440c96b202e7f54650046eb95d3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DPYSL3 SPHK1 ADGRD2 TNXB

9.25e-05170624dcc64b73134e89ae37990d4878813b86ce91dae9
ToppCellnormal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

LMBR1L MIPEP LRP5L PBX1

9.68e-051726240657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCellMonocytes-IFN-activated_Monocytes|Monocytes / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

TGM2 EGLN3 BAZ2A ZG16B

1.06e-041766246a4b403ee3e4dc4f23fbd7a154011e41fd429a9e
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL3 ANK2 SYN3 OGDHL

1.06e-04176624bfea433544c6d6b8ad55e50ca94c5574460c2e0b
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL3 ANK2 SYN3 OGDHL

1.06e-041766243c78dee7e1111a579fde6d401b9ecb4d5b8e782f
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TGM2 SYN3 SPHK1 TNXB

1.08e-04177624227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TGM2 SYN3 SPHK1 TNXB

1.08e-0417762466ffa279147961080c104242a08b176e301d80e3
ToppCellkidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TGM2 SYN3 SPHK1 TNXB

1.08e-041776240cbf54608d2ba0a0500af142f2029fe5e118c3c2
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPYSL3 AASS PBX1 SH3RF3

1.15e-0418062401f2e5d96016823482f89ba503d007d4bd88eeac
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABLIM1 SYN3 RIN2 SH3RF3

1.15e-0418062427e8bbee388e64dd79d70b160b76d45b1f398006
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 KIF13A

1.20e-041826243cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 KIF13A

1.20e-041826245d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 KIF13A

1.28e-04185624efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 RIN2 TMC6 TSC22D4

1.28e-04185624b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 KIF13A

1.28e-041856242e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 KIF13A

1.28e-041856247aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 KIF13A

1.28e-04185624fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TGM2 CENPE ZG16B MYEOV

1.28e-041856244d0f3d86fab02c80093e62cb0c79c586c13c5412
ToppCellControl-Fibroblasts-Alveolar_FB|Control / group, cell type (main and fine annotations)

DPYSL3 SYN3 PBX1 TNXB

1.34e-0418762492d468dde81125d51daf7abd4703741abe1ab91c
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 RIN2 TMC6 TSC22D4

1.34e-0418762497e520705491c8f52a32025311a9fa7b9176979a
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Adult / Lineage, Cell type, age group and donor

ABLIM1 DPYSL3 RIN2 SH3RF3

1.36e-04188624e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCellControl-Fibroblasts-Adventitial_FB|Control / group, cell type (main and fine annotations)

DPYSL3 ANK2 SH3RF3 TNXB

1.36e-04188624706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TSC22D4

1.36e-04188624505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANK2 SYN3 BAIAP3 SLC12A5

1.36e-04188624c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellControl-Endothelial_cells|Control / group, cell type (main and fine annotations)

SYN3 TTC28 RIN2 SH3RF3

1.36e-041886243953b08abfea93468fc8d177bdb16ca7c6ffa1ab
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYN3 MYO6 RIN2 SH3RF3

1.39e-04189624b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TSC22D4

1.39e-04189624784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D175|Adult / Lineage, Cell type, age group and donor

DPYSL3 ANK2 PBX1 TNXB

1.42e-041906247dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TSC22D4

1.42e-041906242de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCellIPF-Endothelial-VE_Capillary_A|IPF / Disease state, Lineage and Cell class

ABLIM1 SYN3 RIN2 SH3RF3

1.42e-04190624b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DPYSL3 ANK2 TTC28 TNXB

1.42e-041906240fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

DPYSL3 ANK2 SH3RF3 TNXB

1.42e-041906243a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPYSL3 ANK2 SPHK1 TNXB

1.45e-04191624f5ce33af56178333730be308253943c54a0724cf
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

EGLN3 MYO6 RIN2 SH3RF3

1.45e-041916241de0bdfd13bd930691564c2673f2e66393bc0255
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS TMC6 TSC22D4

1.45e-041916242110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABLIM1 DPYSL3 MYO6 RIN2

1.45e-04191624f229abf69a1217194f74b0502486907e07dba989
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KANK1 AASS RIN2 TSC22D4

1.45e-04191624f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK2 TTC28 DDX3Y BAIAP3

1.45e-04191624a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCellEndothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|World / Lineage, Cell type, age group and donor

ABLIM1 MYO6 RIN2 SH3RF3

1.48e-041926241e156bab5ecf64627890d2de9b27603d9a01f28d
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPYSL3 ANK2 SPHK1 TNXB

1.48e-04192624a8b7c539dc3037071bf068f372e4215563e11de4
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TGM2 ZG16B MYEOV NDUFA9

1.48e-04192624612be3f861bd2f71a31c57f48c8b10930c3471ea
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABLIM1 MYO6 SH2D3A MTHFD2L

1.48e-041926242510f22197502f60fd266b7f42eff040f25b8ae7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABLIM1 MYO6 SH2D3A MTHFD2L

1.48e-04192624e8e316f396834bcd34843e56e1d86f310fd6aada
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TGM2 ZG16B MYEOV NDUFA9

1.48e-04192624f627a3f43e2340c8ba502211940171f25c7ff436
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell|Adult / Lineage, Cell type, age group and donor

DPYSL3 ANK2 PBX1 TNXB

1.48e-04192624d21f0f577156f17c899b08871046a26b88aea011
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPYSL3 ANK2 SPHK1 TNXB

1.48e-041926242143e1fad2e88b90d668e12af37b2092d379090f
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DPYSL3 ANK2 SPHK1 TNXB

1.48e-04192624904c003c4f73b1dfc8243cee02aad2676c515e50
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYN3 TTC28 RIN2 SH3RF3

1.51e-04193624f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCellLAM-Endothelial-LymEndo|LAM / Condition, Lineage and Cell class

EGLN3 DPYSL3 SPHK1 TNXB

1.51e-0419362468eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYN3 AASS PBX1 TNXB

1.51e-0419362499525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CYP2A13 ATR RIN2 ZG16B

1.51e-041936240ef076417ffe2dd1cbc2c3d1e35c7f8522af143b
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYN3 AASS PBX1 TNXB

1.51e-04193624b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellCOPD-Endothelial|COPD / Disease state, Lineage and Cell class

ABLIM1 DPYSL3 SYN3 SH3RF3

1.51e-04193624093b28dcccb5841c995d0b33fae0efd6b88f97e0
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

DPYSL3 TTC28 PBX1 SH3RF3

1.51e-04193624e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABLIM1 KANK1 MYO6 OGDHL

1.51e-0419362482e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPYSL3 ANK2 PBX1 TNXB

1.51e-041936249ab47b360bee1d4f1092c2269e58acebe9584021
ToppCellPND01|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYN3 SPHK1 RIN2 XDH

1.51e-04193624c291345c11cfcbceacbdc001a5851f67478a2779
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYN3 AASS PBX1 TNXB

1.54e-04194624e93de9428c986b8943fc169258847c650cfab0e5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TGM2 PBX1 SH3RF3 TNXB

1.54e-04194624b490fffc94f005dff9a34ce34d80ca776e3a1387
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TGM2 PBX1 SH3RF3 TNXB

1.54e-04194624fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABLIM1 CYP2A13 ZG16B XDH

1.57e-04195624d7e92bcbd05b93e86a1e1397e44ad27a9e2e637a
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

TGM2 TTC28 PBX1 TNXB

1.57e-04195624603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TGM2 EGLN3 CYP2A13 ZG16B

1.57e-041956246095bb237d7bc75cbaeaeb492f6948f3c3fa4848
ToppCellnucseq-Endothelial-Endothelial_Vascular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYN3 TTC28 RIN2 SH3RF3

1.60e-04196624686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCellNS-critical-d_16-33-Epithelial-Squamous|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MYO6 ZG16B XDH MYEOV

1.60e-0419662497e16d9833e4083d719ca7058d5fc9b11edb37e3
ToppCell368C|World / Donor, Lineage, Cell class and subclass (all cells)

DPYSL3 ANK2 DDX3Y TNXB

1.63e-04197624f41211923938e5d7bfe6bf24f604ab386f17ef10
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|Epithelial / Condition, Lineage and Cell class

TGM2 CYP2A13 DPYSL3 ZG16B

1.63e-0419762478ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCellBronchial_Brush-Epithelial-Club|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

TGM2 CYP2A13 DPYSL3 ZG16B

1.66e-0419862461292a2b5aacb6080a679a31b70a211bdec59a3b
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Epithelial|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

ABLIM1 MYO6 ZG16B MYEOV

1.66e-04198624fb3965049cb1961de0d2e74370868e46aa5050c8
DrugPotassium Chloride

SLC12A6 SLC12A4 SLC12A7 SLC12A5

6.97e-106614DB00761
Drug8-bromoguanosine 3',5'-cyclic monophosphate

SLC12A6 ACTR1B SLC12A4 GUCY2F CACNA1I SLC12A7 TOP2B SLC12A5

1.62e-06308618CID000001915
DrugDCPIB

SLC12A6 SLC12A4 SLC12A5

2.97e-0611613CID010071166
Drug((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid

SLC12A4 SLC12A7

7.06e-062612ctd:C095651
DrugBumetanide

SLC12A6 SLC12A4 SLC12A7

1.00e-0516613ctd:D002034
DrugGanciclovir [82410-32-0]; Up 200; 15.6uM; MCF7; HT_HG-U133A

TGM2 SYN3 BAZ2A CUL9 PHF7 CACNA1I

1.41e-051966163368_UP
DrugCephalexin monohydrate [23325-78-2]; Up 200; 11uM; MCF7; HT_HG-U133A

OGDHL DDX3Y PHF7 CACNA1I KIF13A BAIAP3

1.45e-051976165250_UP
DrugViomycin sulfate [37883-00-4]; Up 200; 5.2uM; HL60; HT_HG-U133A

ABLIM1 SYN3 TMC6 LRP5L PBX1 SLC12A7

1.50e-051986162979_UP
DrugAsiaticoside [16830-15-2]; Down 200; 4.2uM; PC3; HT_HG-U133A

TGM2 ABLIM1 TTC28 TMC6 SH2D3A CUL9

1.50e-051986167244_DN
DrugNSC611747

SLC12A6 ACTR1B SLC12A4 EIF2AK4 SLC12A7 PPM1B SLC12A5

4.24e-05352617CID000002534
Diseaseepilepsy (implicated_via_orthology)

SLC12A6 ANK2 SLC12A4 SLC12A7 SLC12A5

2.43e-05163625DOID:1826 (implicated_via_orthology)
Diseaseurate measurement, bone density

DPYSL3 TTC28 MIPEP EIF2AK4 PBX1 SH3RF3 TNXB

3.13e-04619627EFO_0003923, EFO_0004531
Diseaselean mass-adjusted fat body mass

SYN3 RIN2

6.50e-0418622EFO_0009890
DiseaseChronic myeloproliferative disorder

ATR CENPE

7.26e-0419622C1292778
DiseaseSeckel syndrome

ATR CENPE

9.77e-0422622C0265202
Diseaseosteoporosis (biomarker_via_orthology)

CSHL1 LRP5L

9.77e-0422622DOID:11476 (biomarker_via_orthology)
Diseasemean reticulocyte volume

TTC7A SYN3 ATR SPHK1 TMC6 PBX1 SLC12A7

1.40e-03799627EFO_0010701
Diseaselean mass-adjusted fat body mass, femoral neck bone mineral density

SYN3 RIN2

1.47e-0327622EFO_0007785, EFO_0009890
Diseasereticulocyte count

EEF1AKMT4-ECE2 ATR SPHK1 TMC6 ADGRD2 EIF2AK4 BAIAP3 SLC12A5

1.50e-031045628EFO_0007986
DiseaseDrug habituation

ABLIM1 MYO6 PBX1

1.84e-03115623C0013170
DiseaseSubstance-Related Disorders

ABLIM1 MYO6 PBX1

1.84e-03115623C0236969
DiseaseDrug abuse

ABLIM1 MYO6 PBX1

1.84e-03115623C0013146
DiseaseDrug Use Disorders

ABLIM1 MYO6 PBX1

1.84e-03115623C0013222
DiseaseDrug Dependence

ABLIM1 MYO6 PBX1

1.84e-03115623C1510472
DiseaseSubstance Dependence

ABLIM1 MYO6 PBX1

1.84e-03115623C0038580
DiseaseSubstance Use Disorders

ABLIM1 MYO6 PBX1

1.84e-03115623C0038586
DiseaseOrganic Mental Disorders, Substance-Induced

ABLIM1 MYO6 PBX1

1.84e-03115623C0029231
DiseasePrescription Drug Abuse

ABLIM1 MYO6 PBX1

1.84e-03115623C4316881
DiseaseSubstance abuse problem

ABLIM1 MYO6 PBX1

1.89e-03116623C0740858
Diseaseobsolete_red blood cell distribution width

SYN3 ATR TTC28 SPHK1 TMC6 ADGRD2 EIF2AK4 TSC22D4 SLC12A7

1.92e-031347629EFO_0005192
DiseaseSquamous cell carcinoma of lung

ATR GUCY2F

2.07e-0332622C0149782

Protein segments in the cluster

PeptideGeneStartEntry
DHSGMLVMLPFDLRI

EIF2AK4

1106

Q9P2K8
LPDGHMPAMRMDRGV

ABLIM1

691

O14639
PGDGVEFFAHMRLML

BAIAP3

81

O94812
EMLDAMLKALHPRGI

BAZ2A

1446

Q9UIF9
RMLEMGITGPEGHVL

DPYSL3

211

Q14195
LGLDPGLDHMLAMET

AASS

601

Q9UDR5
RPKHMRVMAGALEGD

ACTR1B

41

P42025
GIQMLMGRLEDGSHL

CSHL1

151

Q14406
MPLGHIMRLDLEKIA

EGLN3

1

Q9H6Z9
RHRLATMPPMVEGEG

ANK2

1011

Q01484
LLPMEETVMDGLHGG

NPHS1

381

O60500
MRLDNMLLAEGVAGP

PBX1

106

P40424
MRLDNMLLAEGVAGP

PBX2

116

P40425
DMDLLHRVVAPGVRM

PCNX3

1631

Q9H6A9
EMGIENVILGMPHRG

OGDHL

286

Q9ULD0
PLGMMTGLDHYIERI

KANK1

816

Q14678
PEEVHGRHGLSMEIM

MYEOV

181

Q96EZ4
MDEPRAIALHPEMGL

LRP5L

76

A4QPB2
IMHLRPMGDLGQLLF

NDUFA9

91

Q16795
DLHGMLEMPDLRDGS

DSG1

876

Q02413
LDYMEELGMLLGGRP

EEF1AKMT4-ECE2

396

P0DPD8
MGEHGLELASMIPAL

ATR

1

Q13535
PEGKNMLIHGRAMLL

ATR

1991

Q13535
IHEIQRFGDMLPMGL

CYP2A13

356

Q16696
RFGDMLPMGLAHRVN

CYP2A13

361

Q16696
DELRMEPLGLEGLNM

CRTC2

656

Q53ET0
MDAELELEMAHGLGP

CACNA1I

1746

Q9P0X4
MEMELLRFGGTPIHF

GUCY2F

426

P51841
MVGERHAGDLMVPLG

CUL9

1

Q8IWT3
IHMDMTEIDPAKGGR

CCDC168

5886

Q8NDH2
DSKEHLAMMERILGP

CLK4

381

Q9HAZ1
HLLVATPGRLVDMME

DDX3Y

316

O15523
IVHDGGMLMLLPFLL

SLC12A6

916

Q9UHW9
IVHDGGMLMLLPFLL

SLC12A7

851

Q9Y666
MMGSEDHLGVIPRAI

CENPE

96

Q02224
DTMHILVDGEDMGPA

NEURL4

1046

Q96JN8
HDGGMLMLLPFLLRH

SLC12A5

856

Q9H2X9
SMMGHAEQLGLIPRL

KIF13A

111

Q9H1H9
MPLIGEHVEEDRQLM

SYN3

371

O14994
NVRRMLDGLDPHPML

TOP2B

896

Q02880
RLRMELGAPEEMGQV

TSC22D4

241

Q9Y3Q8
ILELLIDEAAMPRGM

LMBR1L

321

Q6UX01
EMLRMGIHIPDRDAA

PHF7

216

Q9BWX1
PGRHMDMLTAADRLP

SPATA31E1

1131

Q6ZUB1
KSGEEGMPDLAHVMR

PPM1B

326

O75688
IVHDGGMLMLLPFLL

SLC12A4

851

Q9UP95
GLLEHVLAMEMAPLG

ADGRD2

411

Q7Z7M1
MVLAMLGALHPRAGL

C11orf94

1

C9JXX5
EEVKVRMDLLPLHMG

TGM2

646

P21980
MMELLDPSLLHGEGG

RIN2

721

Q8WYP3
MHDGTIRDLAFMEGP

WDR47

706

O94967
GESPGMHRPEAMLLL

ZG16B

26

Q96DA0
EMLAHGGGREPMLMV

MIPEP

666

Q99797
DLAHMGRSREDPAGM

SH2D3A

151

Q9BRG2
MGMEPLHRKAGSLDL

SH3RF3

786

Q8TEJ3
GEEVPTIEGMRMHLL

TNXB

746

P22105
EDMVGRPLPHLAADM

XDH

571

P47989
MPIAMLLHTDGEHER

MTHFD2L

221

Q9H903
LYDLLIAPMEGGLMH

TTC28

1396

Q96AY4
PDGVRIMHSLGLMLS

TTC7A

776

Q9ULT0
DGLMHEVVNGLMERP

SPHK1

81

Q9NYA1
RDHMLRGMPLSLAEK

TMC6

161

Q7Z403
LGGESDMLGMAEPHR

TRAPPC10

891

P48553
MIGEEPLDHLLGMRA

WDR87

1006

Q6ZQQ6
MKDPLLDDHGDFIRM

MYO6

306

Q9UM54