Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	prostaglandin transmembrane transporter activity	SLCO1B3 SLCO1B1	3.87e-04	14	42	2	GO:0015132
GeneOntologyMolecularFunction	icosanoid transmembrane transporter activity	SLCO1B3 SLCO1B1	4.46e-04	15	42	2	GO:0071714
GeneOntologyMolecularFunction	oligopeptide transmembrane transporter activity	SLCO1B3 SLCO1B1	5.09e-04	16	42	2	GO:0035673
GeneOntologyMolecularFunction	ribosomal large subunit binding	OLA1 LTN1	5.76e-04	17	42	2	GO:0043023
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO1B3 SLCO1B1	6.47e-04	18	42	2	GO:0015347
GeneOntologyBiologicalProcess	oligopeptide transport	SLCO1B3 SLCO1B1 CDH17	1.26e-05	23	41	3	GO:0006857
GeneOntologyBiologicalProcess	cellular response to metal ion	CYP1A2 KCNQ2 SLC13A5 P2RX4 CPNE3	7.08e-05	219	41	5	GO:0071248
GeneOntologyBiologicalProcess	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PCDHB2 CDH17 PCDHB14	1.59e-04	53	41	3	GO:0016339
GeneOntologyBiologicalProcess	determination of adult lifespan	KCNQ2 PRDM2 CGAS	1.69e-04	54	41	3	GO:0008340
GeneOntologyBiologicalProcess	pigment catabolic process	SLCO1B3 SLCO1B1	2.10e-04	11	41	2	GO:0046149
GeneOntologyBiologicalProcess	heme catabolic process	SLCO1B3 SLCO1B1	2.10e-04	11	41	2	GO:0042167
GeneOntologyBiologicalProcess	porphyrin-containing compound metabolic process	CYP1A2 SLCO1B3 SLCO1B1	2.66e-04	63	41	3	GO:0006778
GeneOntologyBiologicalProcess	porphyrin-containing compound catabolic process	SLCO1B3 SLCO1B1	2.97e-04	13	41	2	GO:0006787
GeneOntologyBiologicalProcess	tetrapyrrole catabolic process	SLCO1B3 SLCO1B1	3.46e-04	14	41	2	GO:0033015
GeneOntologyBiologicalProcess	sodium-independent organic anion transport	SLCO1B3 SLCO1B1	3.98e-04	15	41	2	GO:0043252
GeneOntologyBiologicalProcess	tetrapyrrole metabolic process	CYP1A2 SLCO1B3 SLCO1B1	4.12e-04	73	41	3	GO:0033013
HumanPheno	Bilirubinuria	SLCO1B3 SLCO1B1	6.01e-06	2	13	2	HP:0031811
HumanPheno	Storage in hepatocytes	DOCK2 SLCO1B3 SLCO1B1 DNAJC19 CYP19A1	7.26e-05	192	13	5	HP:0031137
HumanPheno	Abnormal liver metabolite concentration	DOCK2 SLCO1B3 SLCO1B1 DNAJC19 CYP19A1	9.48e-05	203	13	5	HP:0034644
HumanPheno	Conjunctival icterus	SLCO1B3 SLCO1B1	1.25e-04	7	13	2	HP:0032106
HumanPheno	Porphyrinuria	SLCO1B3 SLCO1B1	1.67e-04	8	13	2	HP:0010473
HumanPheno	Intermittent jaundice	SLCO1B3 SLCO1B1	2.14e-04	9	13	2	HP:0001046
Domain	Transcription_factor_COE	EBF1 EBF3	2.95e-05	4	42	2	IPR003523
Domain	COE1_HLH	EBF1 EBF3	2.95e-05	4	42	2	PF16423
Domain	COE1_DBD	EBF1 EBF3	2.95e-05	4	42	2	PF16422
Domain	COE_HLH	EBF1 EBF3	2.95e-05	4	42	2	IPR032201
Domain	COE_DBD	EBF1 EBF3	2.95e-05	4	42	2	IPR032200
Domain	COE	EBF1 EBF3	2.95e-05	4	42	2	PS01345
Domain	Transcription_factor_COE_CS	EBF1 EBF3	2.95e-05	4	42	2	IPR018350
Domain	OA_transporter	SLCO1B3 SLCO1B1	3.21e-04	12	42	2	IPR004156
Domain	OATP	SLCO1B3 SLCO1B1	3.21e-04	12	42	2	PF03137
Domain	Chromo_domain	CDYL CHD4	1.32e-03	24	42	2	IPR023780
Domain	Chromo	CDYL CHD4	1.55e-03	26	42	2	PF00385
Domain	IPT	EBF1 EBF3	1.67e-03	27	42	2	SM00429
Domain	CHROMO_2	CDYL CHD4	1.80e-03	28	42	2	PS50013
Domain	CHROMO_1	CDYL CHD4	1.80e-03	28	42	2	PS00598
Domain	Cadherin_CS	PCDHB2 CDH17 PCDHB14	1.88e-03	109	42	3	IPR020894
Domain	Cadherin	PCDHB2 CDH17 PCDHB14	2.08e-03	113	42	3	PF00028
Domain	CADHERIN_1	PCDHB2 CDH17 PCDHB14	2.08e-03	113	42	3	PS00232
Domain	CADHERIN_2	PCDHB2 CDH17 PCDHB14	2.14e-03	114	42	3	PS50268
Domain	-	PCDHB2 CDH17 PCDHB14	2.14e-03	114	42	3	2.60.40.60
Domain	CA	PCDHB2 CDH17 PCDHB14	2.19e-03	115	42	3	SM00112
Domain	TIG	EBF1 EBF3	2.20e-03	31	42	2	PF01833
Domain	Cadherin-like	PCDHB2 CDH17 PCDHB14	2.25e-03	116	42	3	IPR015919
Domain	IPT	EBF1 EBF3	2.35e-03	32	42	2	IPR002909
Domain	Chromodomain-like	CDYL CHD4	2.35e-03	32	42	2	IPR016197
Domain	Cadherin	PCDHB2 CDH17 PCDHB14	2.36e-03	118	42	3	IPR002126
Domain	CHROMO	CDYL CHD4	2.49e-03	33	42	2	SM00298
Domain	Chromo/shadow_dom	CDYL CHD4	2.49e-03	33	42	2	IPR000953
Domain	Kazal_2	SLCO1B3 SLCO1B1	2.96e-03	36	42	2	PF07648
Domain	Cadherin_C_2	PCDHB2 PCDHB14	4.02e-03	42	42	2	PF16492
Domain	Cadherin_C	PCDHB2 PCDHB14	4.02e-03	42	42	2	IPR032455
Domain	Cyt_P450_E_grp-I	CYP1A2 CYP19A1	4.60e-03	45	42	2	IPR002401
Domain	KAZAL	SLCO1B3 SLCO1B1	4.80e-03	46	42	2	SM00280
Domain	DnaJ	SACS DNAJC19	5.43e-03	49	42	2	SM00271
Domain	DNAJ_1	SACS DNAJC19	5.43e-03	49	42	2	PS00636
Domain	DNAJ_2	SACS DNAJC19	5.43e-03	49	42	2	PS50076
Domain	-	SACS DNAJC19	5.43e-03	49	42	2	1.10.287.110
Domain	KAZAL_2	SLCO1B3 SLCO1B1	5.65e-03	50	42	2	PS51465
Domain	DnaJ_domain	SACS DNAJC19	5.87e-03	51	42	2	IPR001623
Domain	Kazal_dom	SLCO1B3 SLCO1B1	5.87e-03	51	42	2	IPR002350
Domain	Cyt_P450_CS	CYP1A2 CYP19A1	6.33e-03	53	42	2	IPR017972
Pathway	WP_SULFATASE_AND_AROMATASE_PATHWAY	SLCO1B3 SLCO1B1 CYP19A1	3.80e-06	14	32	3	M48085
Pathway	REACTOME_ATORVASTATIN_ADME	SLCO1B3 SLCO1B1	1.78e-04	9	32	2	M45020
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO1B3 SLCO1B1	2.71e-04	11	32	2	M930
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO1B3 SLCO1B1	3.25e-04	12	32	2	MM15476
Pathway	WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS	SLCO1B3 SLCO1B1	3.25e-04	12	32	2	M48096
Pathway	REACTOME_HEME_DEGRADATION	SLCO1B3 SLCO1B1	5.15e-04	15	32	2	M27060
Pathway	REACTOME_ATORVASTATIN_ADME	SLCO1B3 SLCO1B1	5.15e-04	15	32	2	MM15697
Pathway	REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS	SLCO1B3 SLCO1B1	7.47e-04	18	32	2	M4862
Pathway	REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS	SLCO1B3 SLCO1B1	8.33e-04	19	32	2	MM14612
Pathway	REACTOME_HEME_DEGRADATION	SLCO1B3 SLCO1B1	9.25e-04	20	32	2	MM14721
Pathway	WP_ESTROGEN_METABOLISM_WP5276	CYP1A2 CYP19A1	1.34e-03	24	32	2	M46445
Pathway	REACTOME_METABOLISM_OF_PORPHYRINS	SLCO1B3 SLCO1B1	1.69e-03	27	32	2	M1088
Pubmed	Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	18314419
Pubmed	OATP 1B1/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	21691816
Pubmed	Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	28063966
Pubmed	Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	22240838
Pubmed	Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	29944058
Pubmed	Association of CYP19A1 and CYP1A2 genetic polymorphisms with type 2 diabetes mellitus risk in the Chinese Han population.	CYP1A2 CYP19A1	1.42e-06	2	42	2	32814585
Pubmed	Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	17412826
Pubmed	SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	36964102
Pubmed	Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	23340295
Pubmed	Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	29777022
Pubmed	Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	26191226
Pubmed	Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	22771883
Pubmed	Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	24194513
Pubmed	Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	18180273
Pubmed	Structure of human drug transporters OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	37723174
Pubmed	Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	24855184
Pubmed	Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	26474710
Pubmed	Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	25578040
Pubmed	Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	23670789
Pubmed	Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	24989890
Pubmed	Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	17496208
Pubmed	Rotor Syndrome	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	23236639
Pubmed	Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	27098745
Pubmed	Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	24740327
Pubmed	Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	21719246
Pubmed	Organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3: genetic variability and haplotype analysis in white Canadians.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	20877131
Pubmed	CYP1A2--a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients.	CYP1A2 CYP19A1	1.42e-06	2	42	2	27029552
Pubmed	Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	16534140
Pubmed	UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	31299240
Pubmed	In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	23886114
Pubmed	OATP1B1/1B3 activity in plated primary human hepatocytes over time in culture.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	21787759
Pubmed	Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.	SLCO1B3 SLCO1B1	1.42e-06	2	42	2	18321482
Pubmed	Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	31047942
Pubmed	Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	26146841
Pubmed	SLCO1B1, SLCO2B1, and SLCO1B3 polymorphisms and susceptibility to bladder cancer risk.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	24762081
Pubmed	Contribution of CYP19A1, CYP1A1, and CYP1A2 polymorphisms in coronary heart disease risk among the Chinese Han population.	CYP1A2 CYP19A1	4.27e-06	3	42	2	35380334
Pubmed	Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	18296417
Pubmed	Interaction Between Sex and Organic Anion-Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib-N-Oxide and Regorafenib-Glucuronide in Mice.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	30955241
Pubmed	Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	20660695
Pubmed	Influence of drug formulation on OATP1B-mediated transport of paclitaxel.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	24755470
Pubmed	The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development.	EBF1 EBF3	4.27e-06	3	42	2	9151732
Pubmed	OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	29337310
Pubmed	Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	22136368
Pubmed	Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	31967785
Pubmed	Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	28013215
Pubmed	The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	19890249
Pubmed	HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	20051929
Pubmed	Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	19620935
Pubmed	Identification of novel cell-impermeant fluorescent substrates for testing the function and drug interaction of Organic Anion-Transporting Polypeptides, OATP1B1/1B3 and 2B1.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	29422623
Pubmed	Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	24825069
Pubmed	Adenomyosis: genetics of estrogen metabolism.	CYP1A2 CYP19A1	4.27e-06	3	42	2	30878995
Pubmed	Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	22695893
Pubmed	Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	18492796
Pubmed	Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	28389619
Pubmed	Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	26383540
Pubmed	Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	23986199
Pubmed	Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	18413659
Pubmed	Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	22203093
Pubmed	Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	20949553
Pubmed	Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake of Glucuronide Metabolites of Androgens.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	32587096
Pubmed	Comparison of genetic variations of the SLCO1B1, SLCO1B3, and SLCO2B1 genes among five ethnic groups.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	26409184
Pubmed	Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	19400585
Pubmed	Synergistic interaction between genetics and disease on pravastatin disposition.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	24613363
Pubmed	OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	30218633
Pubmed	Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	25391605
Pubmed	Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1).	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	10833452
Pubmed	Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.	SLCO1B3 SLCO1B1	4.27e-06	3	42	2	10779507
Pubmed	Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.	SLCO1B3 SLCO1B1	8.53e-06	4	42	2	22294745
Pubmed	Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.	CYP1A2 CYP19A1	8.53e-06	4	42	2	18941913
Pubmed	Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.	SLCO1B3 SLCO1B1	8.53e-06	4	42	2	20644253
Pubmed	Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development.	EBF1 EBF3	8.53e-06	4	42	2	9151733
Pubmed	Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.	SLCO1B3 SLCO1B1	8.53e-06	4	42	2	17906856
Pubmed	Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.	SLCO1B3 SLCO1B1	8.53e-06	4	42	2	21849517
Pubmed	Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2.	SLCO1B3 SLCO1B1	8.53e-06	4	42	2	25280775
Pubmed	Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.	SLCO1B3 SLCO1B1	8.53e-06	4	42	2	19442037
Pubmed	Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection.	EBF1 EBF3	8.53e-06	4	42	2	12139918
Pubmed	Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk.	CYP1A2 CYP19A1	8.53e-06	4	42	2	16402077
Pubmed	Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.	SLCO1B3 SLCO1B1	8.53e-06	4	42	2	27777271
Pubmed	Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.	SLCO1B3 SLCO1B1	1.42e-05	5	42	2	38279097
Pubmed	OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.	SLCO1B3 SLCO1B1	1.42e-05	5	42	2	24194565
Pubmed	Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11.	EBF1 EBF3	1.42e-05	5	42	2	12917357
Pubmed	Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk.	SLCO1B3 SLCO1B1	1.42e-05	5	42	2	20635135
Pubmed	Stem cell niche-specific Ebf3 maintains the bone marrow cavity.	EBF1 EBF3	1.42e-05	5	42	2	29563184
Pubmed	Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia.	CYP1A2 CYP19A1	1.42e-05	5	42	2	18497059
Pubmed	Expression patterns of the coe/ebf transcription factor genes during chicken and mouse limb development.	EBF1 EBF3	1.42e-05	5	42	2	15261831
Pubmed	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	SLCO1B3 SLCO1B1	2.13e-05	6	42	2	22232210
Pubmed	Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity.	SLCO1B3 SLCO1B1	2.13e-05	6	42	2	20212519
Pubmed	Analysis of DNA methylation and histone modification profiles of liver-specific transporters.	SLCO1B3 SLCO1B1	2.13e-05	6	42	2	19047482
Pubmed	The transcription factor, Lmx1b, is necessary for the development of the principal trigeminal nucleus-based lemniscal pathway.	EBF1 EBF3	2.13e-05	6	42	2	20621716
Pubmed	Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system.	EBF1 EBF3	2.13e-05	6	42	2	9389446
Pubmed	Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.	EBF1 EBF3	2.98e-05	7	42	2	24786561
Pubmed	Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.	CYP1A2 CYP19A1	2.98e-05	7	42	2	17615053
Pubmed	Effect of hormone metabolism genotypes on steroid hormone levels and menopausal symptoms in a prospective population-based cohort of women experiencing the menopausal transition.	CYP1A2 CYP19A1	2.98e-05	7	42	2	20505544
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	OLA1 CEBPZ ATP13A1 DNAJC19 MRPS25 PRRC2B LTN1	3.05e-05	754	42	7	33060197
Pubmed	TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation.	EBF1 EBF3	3.97e-05	8	42	2	32179550
Pubmed	Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women.	CYP1A2 CYP19A1	3.97e-05	8	42	2	15241822
Pubmed	Mammalian chromodomain proteins: their role in genome organisation and expression.	CDYL CHD4	3.97e-05	8	42	2	10655032
Pubmed	Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.	SLCO1B3 SLCO1B1	3.97e-05	8	42	2	19129463
Pubmed	Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection.	EBF1 EBF3	3.97e-05	8	42	2	14993187
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	EBF1 OLA1 EBF3 DNAJC19 TECTB	3.99e-05	318	42	5	16919269
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	SACS DNAJC19	2.24e-03	49	26	2	584
GeneFamily	Clustered protocadherins	PCDHB2 PCDHB14	3.80e-03	64	26	2	20
GeneFamily	Mitochondrial ribosomal proteins	MRPS25 LACTB	5.72e-03	79	26	2	646
GeneFamily	Solute carriers	SLCO1B3 SLC13A5 SLCO1B1	1.85e-02	395	26	3	752
Drug	AC1Q7BBT	CYP1A2 SLCO1B3 SLCO1B1	2.09e-06	14	42	3	CID000086545
Drug	(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid	SLCO1B3 SLCO1B1	3.32e-06	2	42	2	ctd:C561635
Drug	Clarithromycin	CYP1A2 SLCO1B3 SLCO1B1	8.77e-06	22	42	3	ctd:D017291
Drug	CI-1034	CYP1A2 SLCO1B3 SLCO1B1	8.77e-06	22	42	3	CID000157574
Drug	estrone sulfate	CYP1A2 SLCO1B3 SLCO1B1 CYP19A1 PRDM2	1.21e-05	163	42	5	CID000000699
Drug	rifamycin SV	SLCO1B3 SLCO1B1	1.99e-05	4	42	2	ctd:C023808
Drug	thiacloprid	CYP1A2 CYP19A1	1.99e-05	4	42	2	ctd:C417209
Drug	microcystin-LF	SLCO1B3 SLCO1B1	1.99e-05	4	42	2	ctd:C524165
Drug	Dihydromicrocystin Lr	SLCO1B3 SLCO1B1	1.99e-05	4	42	2	CID006441227
Drug	2,2',4,4',5,6'-hexabromodiphenyl ether	SLCO1B3 SLCO1B1	3.31e-05	5	42	2	ctd:C555859
Drug	trospium chloride	SLCO1B3 SLCO1B1	4.96e-05	6	42	2	ctd:C003330
Drug	prednisolone phosphate	SLCO1B3 SLCO1B1	4.96e-05	6	42	2	CID000004896
Drug	naringenin	CYP1A2 SLCO1B3 SLCO1B1 CYP19A1	5.19e-05	111	42	4	ctd:C005273
Drug	nateglinide	SLCO1B3 SLCO1B1	6.94e-05	7	42	2	ctd:C060142
Drug	demethylphalloin	SLCO1B3 SLCO1B1	6.94e-05	7	42	2	CID000114793
Drug	TAK-875	SLCO1B3 SLCO1B1	9.24e-05	8	42	2	ctd:C557331
Drug	Fusidic Acid	SLCO1B3 SLCO1B1	9.24e-05	8	42	2	ctd:D005672
Drug	NSC263652	SLCO1B3 SLCO1B1	9.24e-05	8	42	2	CID000429721
Drug	5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid	SLCO1B3 SLCO1B1	1.19e-04	9	42	2	ctd:C000588958
Drug	7-hydroxyflavone	CYP1A2 CYP19A1	1.19e-04	9	42	2	CID005281894
Drug	AC1L1FXT	ACE2 EBF1 EBF3	1.28e-04	53	42	3	CID000003439
Drug	oxadiazon	CYP1A2 CYP19A1	1.48e-04	10	42	2	ctd:C012466
Drug	Y-S-H	SLCO1B3 SLCO1B1	1.48e-04	10	42	2	CID000449035
Drug	NSC 60593	SLCO1B1 CYP19A1	1.48e-04	10	42	2	CID000089340
Drug	obeticholic acid	CYP1A2 SLCO1B3 SLC13A5 SLCO1B1 CYP19A1	1.67e-04	283	42	5	ctd:C464660
Drug	nafcillin	CYP1A2 SLCO1B1	1.81e-04	11	42	2	CID000008982
Drug	7-hydroxyflavone	CYP1A2 CYP19A1	1.81e-04	11	42	2	ctd:C429845
Drug	repaglinide	SLCO1B3 SLCO1B1	1.81e-04	11	42	2	ctd:C072379
Drug	microcystin	SLCO1B3 SLCO1B1	1.81e-04	11	42	2	ctd:C078588
Drug	2-hydroxyestradiol	CYP1A2 SACS CYP19A1	2.15e-04	63	42	3	CID000009684
Drug	chloro-s-triazine	CYP1A2 CYP19A1	2.17e-04	12	42	2	CID005215566
Drug	glimepiride	SLCO1B3 SLCO1B1	2.17e-04	12	42	2	ctd:C057619
Drug	3-methyleneindolenine	CYP1A2 CYP19A1	2.17e-04	12	42	2	CID000170404
Drug	pentachlorobenzene	CYP1A2 CYP19A1	2.17e-04	12	42	2	ctd:C003060
Drug	2-C5	ACE2 CYP1A2 CYP19A1	2.25e-04	64	42	3	CID005287467
Drug	rifampicin	CYP1A2 SLCO1B3 OLA1 SLCO1B1 CYP19A1	2.40e-04	306	42	5	CID005381226
Drug	Pyrrolizidine Alkaloids	CYP1A2 SLCO1B3 SLCO1B1	2.46e-04	66	42	3	ctd:D011763
Drug	2-benzoxazolinone	CYP1A2 CYP19A1	2.56e-04	13	42	2	CID000006043
Drug	aprikalim	EBF1 SACS	2.56e-04	13	42	2	CID003034038
Drug	Phalloidine	SLCO1B3 SLCO1B1	2.56e-04	13	42	2	ctd:D010590
Drug	estrone-d4	CYP1A2 EBF1 EBF3 CYP19A1	2.57e-04	168	42	4	CID000000698
Disease	Rotor syndrome	SLCO1B3 SLCO1B1	1.79e-06	2	40	2	cv:C0220991
Disease	HYPERBILIRUBINEMIA, ROTOR TYPE, DIGENIC	SLCO1B3 SLCO1B1	1.79e-06	2	40	2	C4016905
Disease	HYPERBILIRUBINEMIA, ROTOR TYPE	SLCO1B3 SLCO1B1	1.79e-06	2	40	2	237450
Disease	Rotor Syndrome	SLCO1B3 SLCO1B1	1.79e-06	2	40	2	C0220991
Disease	bilirubin metabolic disorder (implicated_via_orthology)	SLCO1B3 SLCO1B1	1.79e-05	5	40	2	DOID:2741 (implicated_via_orthology)
Disease	bilirubin metabolic disorder (is_implicated_in)	SLCO1B3 SLCO1B1	2.68e-05	6	40	2	DOID:2741 (is_implicated_in)
Disease	deoxycholic acid glucuronide measurement	SLCO1B3 SLCO1B1	4.99e-05	8	40	2	EFO_0800575
Disease	hexadecenedioate (C16:1-DC) measurement	SLCO1B3 SLCO1B1	6.41e-05	9	40	2	EFO_0800562
Disease	X-21467 measurement	SLCO1B3 SLCO1B1	6.41e-05	9	40	2	EFO_0020007
Disease	glycochenodeoxycholate glucuronide (1) measurement	SLCO1B3 SLCO1B1	1.38e-04	13	40	2	EFO_0800474
Disease	MAJOR AFFECTIVE DISORDER 2	KCNQ2 CDH17	2.41e-04	17	40	2	C1839839
Disease	urinary metabolite measurement	ARHGAP17 SLCO1B1 LACTB FAM209B	3.35e-04	245	40	4	EFO_0005116
Disease	Child Development Disorders, Specific	KCNQ2 CHD4	7.11e-04	29	40	2	C0085997
Disease	Child Development Deviations	KCNQ2 CHD4	7.11e-04	29	40	2	C0085996
Disease	Developmental Disabilities	KCNQ2 CHD4	7.61e-04	30	40	2	C0008073
Disease	endometrial cancer (is_implicated_in)	CYP1A2 CYP19A1	1.10e-03	36	40	2	DOID:1380 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
NFRNVKAVKFPTPLR	ADCK2	376	Q7Z695
KKQFLPVAFPVGNAF	ATP13A1	186	Q9HD20
IVQFVPFRQFQNAPK	CPNE3	486	O75131
RAVKVNFLKPPPNFN	ADCY10	211	Q96PN6
VKFKRNPKENPLSQF	CGAS	251	Q8N884
PKFNFSKRNILPNIT	P2RX4	196	Q99571
PNPALQRFKAFNQRF	CYP1A2	246	P05177
DIIFFKFNTPQQPKK	OLA1	381	Q9NTK5
FKFLKPIIPNFVAQG	PCDHB2	766	Q9Y5E7
PQSITNPKLDFFKNF	LTN1	371	O94822
RLFKNDPLFFKPGSQ	LACTB	306	P83111
KPPKRNAFYRKLQNF	KCNQ2	66	O43526
PFNKNNKFNALPRSI	KIAA1586	591	Q9HCI6
RGFPFRTPLKKNQNA	FAM209B	91	Q5JX69
NNLTTFFNFKPPKNL	LRGUK	181	Q96M69
QDNLPFFLKPTFKNF	PCDHB14	386	Q9Y5E9
TNEFKFLKPIIPNFQ	PCDHB14	761	Q9Y5E9
NVVNPDLKRFPQFRK	HSPBAP1	221	Q96EW2
FKNKPVPDQIINFYK	DOCK2	1421	Q92608
AIRNFVNTFIQFKKP	CDYL	426	Q9Y232
FFPKPNEFTLENFAK	CYP19A1	406	P11511
KPRISFNFFVTAPKN	ACE2	676	Q9BYF1
AVQAINKLNPKPKFF	CPPED1	71	Q9BRF8
KQPPSNLRKSNFFHF	EBF1	56	Q9UH73
KQPPSNLRKSNFFHF	EBF3	56	Q9H4W6
QIIFQFKANPPAVTF	CDH17	46	Q12864
FSQFVRPLIAAKNPK	CHD4	181	Q14839
LLFIVPSQKPKFNFR	SLC13A5	366	Q86YT5
LRKFPNQFKPFIDVF	SACS	1611	Q9NZJ4
KQLNKYDPFSRNPLF	CEBPZ	691	Q03701
RKVKAPAAAQFQGPF	PRDM2	1701	Q13029
VVKARQPKPFFAAGN	PTGFRN	551	Q9P2B2
KFVFFNIPQIQYKNP	MRPS25	46	P82663
KLPPQNFVNFRYLIK	ARHGAP17	366	Q68EM7
FNAFRFQNIPKLSKV	TECTB	246	Q96PL2
FFFLPQTPNKPQKER	SLCO1B1	276	Q9Y6L6
LPQKQKVLPVFYFAR	USP19	676	O94966
KKPVLFSFQPNHFFN	VPS13A	2241	Q96RL7
YRIFQKKPQFLSAAP	ZNF519	121	Q8TB69
FPQVQAFVRSDKPKL	SELENOF	101	O60613
FFFLPKNPNKPQKER	SLCO1B3	276	Q9NPD5
QEFKYQKSLPPRFQR	PRRC2B	616	Q5JSZ5
PQVKQVFQSLPKSAF	DNAJC19	31	Q96DA6
KQNFAPFNVLVPRFK	PIFO	106	Q8TCI5