Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	MOZ/MORF histone acetyltransferase complex	ING5 KAT6B	8.22e-05	7	42	2	GO:0070776
GeneOntologyCellularComponent	H3 histone acetyltransferase complex	ING5 KAT6B	1.10e-04	8	42	2	GO:0070775
Domain	DUF1220	NBPF4 NBPF15 NBPF6 NBPF7P NBPF11 NBPF9 NBPF1	1.91e-18	9	36	7	SM01148
Domain	NBPF	NBPF4 NBPF15 NBPF6 NBPF7P NBPF11 NBPF9 NBPF1	1.74e-17	11	36	7	PS51316
Domain	DUF1220	NBPF4 NBPF15 NBPF6 NBPF7P NBPF11 NBPF9 NBPF1	1.74e-17	11	36	7	PF06758
Domain	NBPF_dom	NBPF4 NBPF15 NBPF6 NBPF7P NBPF11 NBPF9 NBPF1	1.74e-17	11	36	7	IPR010630
Domain	SANT_dom	NCOR1 MYSM1	1.14e-03	26	36	2	IPR017884
Domain	SANT	NCOR1 MYSM1	1.32e-03	28	36	2	PS51293
Domain	Myb_DNA-binding	NCOR1 MYSM1	2.07e-03	35	36	2	PF00249
Domain	MYB_LIKE	NCOR1 MYSM1	2.43e-03	38	36	2	PS50090
Domain	SANT	NCOR1 MYSM1	4.18e-03	50	36	2	SM00717
Domain	SANT/Myb	NCOR1 MYSM1	4.51e-03	52	36	2	IPR001005
Domain	KRAB	ZNF267 ZNF98 ZNF529 ZNF254	4.82e-03	358	36	4	PS50805
Domain	KRAB	ZNF267 ZNF98 ZNF529 ZNF254	4.82e-03	358	36	4	PF01352
Domain	KRAB	ZNF267 ZNF98 ZNF529 ZNF254	5.36e-03	369	36	4	SM00349
Domain	KRAB	ZNF267 ZNF98 ZNF529 ZNF254	5.41e-03	370	36	4	IPR001909
Domain	PHD	ING5 KAT6B	9.18e-03	75	36	2	PF00628
Domain	zf-C2H2	ZNF267 ZSCAN5DP ZNF98 ZNF529 ZNF254	1.01e-02	693	36	5	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF267 ZSCAN5DP ZNF98 ZNF529 ZNF254	1.01e-02	694	36	5	IPR013087
Domain	Znf_PHD-finger	ING5 KAT6B	1.01e-02	79	36	2	IPR019787
Domain	PHD	ING5 KAT6B	1.27e-02	89	36	2	SM00249
Domain	Znf_PHD	ING5 KAT6B	1.33e-02	91	36	2	IPR001965
Domain	ZF_PHD_2	ING5 KAT6B	1.44e-02	95	36	2	PS50016
Domain	ZF_PHD_1	ING5 KAT6B	1.47e-02	96	36	2	PS01359
Domain	ZINC_FINGER_C2H2_2	ZNF267 ZSCAN5DP ZNF98 ZNF529 ZNF254	1.58e-02	775	36	5	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF267 ZSCAN5DP ZNF98 ZNF529 ZNF254	1.59e-02	777	36	5	PS00028
Domain	Znf_C2H2-like	ZNF267 ZSCAN5DP ZNF98 ZNF529 ZNF254	1.75e-02	796	36	5	IPR015880
Domain	Znf_C2H2	ZNF267 ZSCAN5DP ZNF98 ZNF529 ZNF254	1.83e-02	805	36	5	IPR007087
Domain	ZnF_C2H2	ZNF267 ZSCAN5DP ZNF98 ZNF529 ZNF254	1.86e-02	808	36	5	SM00355
Pubmed	A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.	NBPF10 NBPF8 NBPF4 NBPF19 NBPF15 NBPF6 NBPF7P NBPF12 NBPF5P NBPF11 NBPF9 NBPF1	6.86e-31	21	43	12	16079250
Pubmed	Evolutionary history and genome organization of DUF1220 protein domains.	NBPF8 NBPF15 NBPF6 NBPF12 NBPF9 NBPF1	5.19e-16	10	43	6	22973535
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	NBPF10 NBPF8 NBPF12 NBPF11 NBPF9 NBPF1	6.55e-08	170	43	6	23314748
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NBPF10 NBPF8 NBPF15 NBPF12 NBPF11 NBPF9 HSP90AA1 NBPF1	1.96e-07	513	43	8	25798074
Pubmed	Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.	NBPF11 NBPF1	1.49e-06	2	43	2	7700633
Pubmed	Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.	TBK1 HSP90AA1	4.48e-06	3	43	2	31189704
Pubmed	Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation.	RB1CC1 TBK1	4.48e-06	3	43	2	34903812
Pubmed	Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex.	TBK1 HSP90AA1	8.94e-06	4	43	2	29743370
Pubmed	Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells.	TBK1 HSP90AA1	8.94e-06	4	43	2	16394098
Pubmed	Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.	NBPF11 NBPF1	1.49e-05	5	43	2	20096688
Pubmed	MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway.	MYSM1 TBK1	1.49e-05	5	43	2	33086059
Pubmed	Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.	RB1CC1 TBK1	3.12e-05	7	43	2	28877469
Pubmed	Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.	ING5 KAT6B	3.12e-05	7	43	2	18794358
Pubmed	Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.	NCOR1 HSP90AA1	3.12e-05	7	43	2	17210713
Pubmed	Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy.	RB1CC1 TBK1	4.16e-05	8	43	2	30853401
Pubmed	Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.	RB1CC1 TBK1 HSP90AA1	4.66e-05	56	43	3	27103069
Pubmed	Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.	TBK1 HSP90AA1	5.35e-05	9	43	2	20628368
Pubmed	Autophagy Is Required for Maturation of Surfactant-Containing Lamellar Bodies in the Lung and Swim Bladder.	RB1CC1 HSP90AA1	5.35e-05	9	43	2	33296658
Pubmed	A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.	ING5 CHEK2 HSP90AA1	7.29e-05	65	43	3	27453043
Pubmed	Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.	CHEK2 HSP90AA1	8.15e-05	11	43	2	15001356
Pubmed	Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.	MYSM1 TBK1	9.78e-05	12	43	2	26474655
Pubmed	The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling.	CD99 HSP90AA1	1.15e-04	13	43	2	20374249
Pubmed	LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.	CYBB RB1CC1	1.55e-04	15	43	2	30245008
Pubmed	Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.	NDNF ARID1B	2.80e-04	20	43	2	34220450
Pubmed	Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic-Like Behaviors.	DNAH6 TBK1	3.40e-04	22	43	2	33304758
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	CHEK2 NCOR1 TBK1	3.46e-04	110	43	3	37219487
Pubmed	A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.	CYBB HSP90AA1	6.79e-04	31	43	2	32245826
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	EIF5B NCOR1 ARID1B KAT6B	8.29e-04	341	43	4	32971831
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	RB1CC1 TBK1 HSP90AA1	8.55e-04	150	43	3	32423001
Pubmed	Global Proximity Interactome of the Human Macroautophagy Pathway.	RB1CC1 TBK1	8.66e-04	35	43	2	34524948
Pubmed	Interaction network of human early embryonic transcription factors.	NCOR1 ARID1B SOBP TBK1	9.23e-04	351	43	4	38297188
Pubmed	Systematic and quantitative assessment of the ubiquitin-modified proteome.	NBPF12 NBPF11 MYSM1	9.94e-04	158	43	3	21906983
Cytoband	1q21.1	NBPF10 NBPF8 NBPF11 NBPF9	3.58e-07	62	43	4	1q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	NBPF10 NBPF19 NBPF15 NBPF12 NBPF11 NBPF9	2.07e-06	404	43	6	chr1q21
Cytoband	1p13.3	NBPF4 NBPF6 NBPF5P	3.84e-05	69	43	3	1p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1p13	NBPF4 NBPF6 NBPF5P	1.03e-03	211	43	3	chr1p13
Cytoband	19p12	ZNF98 ZNF254	3.26e-03	90	43	2	19p12
Cytoband	1q21	CASQ1 NBPF12	3.33e-03	91	43	2	1q21
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF98 ZNF254	5.89e-03	122	43	2	chr19p12
GeneFamily	Neuroblastoma breakpoint family	NBPF10 NBPF8 NBPF4 NBPF19 NBPF15 NBPF6 NBPF7P NBPF12 NBPF5P NBPF11 NBPF9 NBPF1	1.87e-28	23	33	12	662
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR1 MYSM1	4.20e-03	53	33	2	532
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF267 ZSCAN5DP ZNF98 ZNF529 ZNF254	9.19e-03	718	33	5	28
GeneFamily	PHD finger proteins	ING5 KAT6B	1.17e-02	90	33	2	88
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	BCLAF3 NBPF10 NBPF15 NBPF11 NBPF1	2.34e-07	143	42	5	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	Control-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF10 NBPF15 NBPF12 NBPF11 NBPF1	2.42e-07	144	42	5	984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF10 NBPF15 NBPF12 NBPF11 NBPF1	5.05e-07	167	42	5	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	Severe-B_intermediate-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	BCLAF3 NBPF10 NBPF11 NBPF1	6.04e-06	126	42	4	42a0bdbe18ef85146cac4e86b2b27d0b3b20d8a2
ToppCell	Control-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF10 NBPF15 NBPF11 NBPF1	1.37e-05	155	42	4	0a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CYBB NBPF10 NBPF15 NBPF1	1.51e-05	159	42	4	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	Control-B_naive-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NBPF10 NBPF15 NBPF11 NBPF1	2.01e-05	171	42	4	d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell	COVID-19_Convalescent\|World / Disease Group and Platelet Clusters	ZNF267 NBPF11 ZNF529 NBPF9	2.21e-05	175	42	4	e9b1faa4c85537f30306619a2f3ada6c8ef0ac6c
ToppCell	COVID-19_Mild-CD4+_T_activated\|COVID-19_Mild / Disease condition and Cell class	NBPF10 NBPF15 NBPF11 NBPF1	2.57e-05	182	42	4	877b6e611626628e709568747512f2827ebb2795
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB ZNF267 LCP2 HSP90AA1	3.04e-05	190	42	4	a5c64d024f2908d30d1e2897a45baf3a67b103b5
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Trm_gut_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	LCP2 MSMO1 CD99 HSP90AA1	3.57e-05	198	42	4	aedd91e734bd919cf6b8c1586ad0cbd6e6d0f2ed
ToppCell	(00)_Basal-(2)_GFP_FOXI1\|(00)_Basal / shred by cell type by condition	EIF5B RB1CC1 SOBP HSP90AA1	3.64e-05	199	42	4	19674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	EIF5B RB1CC1 SOBP HSP90AA1	3.64e-05	199	42	4	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
Drug	Pesticides	NBPF10 NBPF8 NBPF15 NBPF7P NBPF12 NBPF11 NBPF9 NBPF1	1.89e-10	150	40	8	ctd:D010575
Disease	Breast adenocarcinoma	CHEK2 NCOR1 ARID1B	1.72e-05	41	36	3	C0858252
Disease	Neoplasm of uncertain or unknown behavior of breast	CHEK2 NCOR1 ARID1B	1.72e-05	41	36	3	C0496956
Disease	Breast Carcinoma	CHEK2 NCOR1 ARID1B RB1CC1 HSP90AA1	4.67e-04	538	36	5	C0678222
Disease	Malignant tumor of breast	CHEK2 RB1CC1	4.98e-04	27	36	2	cv:C0006142
Disease	Breast neoplasm	CHEK2 RB1CC1	4.98e-04	27	36	2	cv:C1458155
Disease	Familial cancer of breast	CHEK2 RB1CC1	4.98e-04	27	36	2	cv:C0346153
Disease	breast cancer (is_implicated_in)	CHEK2 RB1CC1 KAT6B	8.13e-04	150	36	3	DOID:1612 (is_implicated_in)
Disease	Neuroblastoma	CHEK2 ARID1B	1.51e-03	47	36	2	C0027819
Disease	developmental disorder of mental health (implicated_via_orthology)	NCOR1 NAA16	1.64e-03	49	36	2	DOID:0060037 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	CHEK2 NCOR1 ARID1B RB1CC1 KAT6B HSP90AA1	1.75e-03	1074	36	6	C0006142
Disease	Mammary Neoplasms, Human	CHEK2 NCOR1 RB1CC1 HSP90AA1	3.72e-03	525	36	4	C1257931
Disease	Mammary Carcinoma, Human	CHEK2 NCOR1 RB1CC1 HSP90AA1	3.72e-03	525	36	4	C4704874
Disease	Mammary Neoplasms	CHEK2 NCOR1 RB1CC1 HSP90AA1	3.77e-03	527	36	4	C1458155

Protein segments in the cluster

Peptide	Gene	Start	Entry
EFYKFTQKYQKKLQD	CCDC148	231	Q8NFR7
LKKQYIQYLFAFECK	ARID1B	1211	Q8NFD5
IAYQKKKLCFKENAE	CD99	146	P14209
NKRLKEATCKLYFYQ	CHEK2	316	O96017
SLANQLKKYKCEEYK	NBPF4	51	Q96M43
GYFSKEKLCQQKYNV	KAT6B	841	Q8WYB5
SQYNAYNEKRKKFEK	MSMO1	276	Q15800
EKEYCQAKKAQNRFK	RB1CC1	1561	Q8TDY2
QKFIDDCKYYNDSKQ	MCMDC2	21	Q4G0Z9
FKKQQRKFQYGNYCK	MEPCE	406	Q7L2J0
YEQKQYKNGLKFCKM	NAA16	21	Q6N069
NKFCIYKKEVDDNYN	NDNF	476	Q8TB73
FNKFSKYYQKQKDID	KCNS3	406	Q9BQ31
LANRQKKYKYEECKD	NBPF1	51	Q3BBV0
FLANQQNKYKYEECK	NBPF1	321	Q3BBV0
QNKYKYEECKDLIKS	NBPF1	326	Q3BBV0
QKRAFQYKSYQKNFK	DNAH6	856	Q9C0G6
QKYCKEEDRKYSFQK	BCLAF3	301	A2AJT9
NVNAKNYKNVFKKYE	CASQ1	51	P31415
QKIQNAYSKCKEYSD	ING5	66	Q8WYH8
KYCNNATNLKLKKIY	CYBB	426	P04839
KENYKKFYEQFSKNI	HSP90AA1	431	P07900
YKEKRQNKSYVVACK	RNASE7	121	Q9H1E1
SLANQLKKYKCEEYK	NBPF5P	51	Q86XG9
SLANQLKKYKCEEYK	NBPF6	51	Q5VWK0
LANQQNKYKYEECKD	NBPF7P	71	P0C2Y1
FLAKQQNKYKYEECK	NBPF8	286	Q3BBV2
QNKYKYEECKDLIKS	NBPF8	291	Q3BBV2
LANRQKKYKYEECKD	NBPF9	51	P0DPF3
FLANQQNKYKYEECK	NBPF9	321	P0DPF3
QNKYKYEECKDLIKF	NBPF9	326	P0DPF3
LANRQKKYKYEECKD	NBPF10	51	Q6P3W6
FLANQQKKYKYEECK	NBPF10	321	Q6P3W6
LANRQKKYKYEECKD	NBPF11	51	Q86T75
FLAKQQNKYKYEECK	NBPF11	321	Q86T75
QNKYKYEECKDLIKS	NBPF11	326	Q86T75
LANRQKKYKYEECKD	NBPF12	51	Q5TAG4
FLAKQQNKYKYEECK	NBPF12	321	Q5TAG4
QNKYKYEECKDLIKS	NBPF12	326	Q5TAG4
CFLAKQQNKYKYEEC	NBPF12	591	Q5TAG4
QQNKYKYEECKDLLK	NBPF12	596	Q5TAG4
LANRQKKYKYEECKD	NBPF15	51	Q8N660
LANRQKKYKYEECKD	NBPF19	51	A0A087WUL8
KYRQDYKKQKQEEFK	EIF5B	1071	O60841
TKSEAQCKNFYFNYK	NCOR1	656	O75376
YKCKDCNQVFTYRKN	ZSCAN5DP	436	P0CG00
SAKCLNQYKMDIFYK	SOBP	251	A7XYQ1
ENYFLEKQYKCKEFE	ZNF267	236	Q14586
RKKYYTCNYCKKEFN	ZNF840P	301	A6NDX5
KNYFQKVILRTYKKC	ZNF98	101	A6NK75
QKIHNEKFYKCKEYR	ZNF529	246	Q6P280
SKVFQCDKYLKVFYK	ZNF254	151	O75437
CDKYLKVFYKFLNSN	ZNF254	156	O75437
LNCMTEIYYQFKKDK	TBK1	556	Q9UHD2
ADYFKKLNYKDCEKA	LCP2	21	Q13094
KSYARQYFKNKVKCG	MYSM1	156	Q5VVJ2