Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	FAD binding	DDO MICAL3 MICAL2	4.73e-05	44	32	3	GO:0071949
Domain	FAD_binding_3	MICAL3 MICAL2	4.52e-05	6	33	2	PF01494
Domain	FAD-bd	MICAL3 MICAL2	4.52e-05	6	33	2	IPR002938
Domain	-	DDO MICAL3 MICAL2	1.31e-04	56	33	3	3.50.50.60
Domain	FAD/NAD-binding_dom	DDO MICAL3 MICAL2	1.38e-04	57	33	3	IPR023753
Domain	CH	MICAL3 MICAL2	5.87e-03	65	33	2	SM00033
Domain	LIM	MICAL3 MICAL2	6.60e-03	69	33	2	PF00412
Domain	-	MICAL3 MICAL2	6.78e-03	70	33	2	2.10.110.10
Domain	CH	MICAL3 MICAL2	6.78e-03	70	33	2	PF00307
Domain	LIM_DOMAIN_2	MICAL3 MICAL2	6.97e-03	71	33	2	PS50023
Domain	Znf_LIM	MICAL3 MICAL2	6.97e-03	71	33	2	IPR001781
Domain	LIM_DOMAIN_1	MICAL3 MICAL2	6.97e-03	71	33	2	PS00478
Domain	-	MICAL3 MICAL2	6.97e-03	71	33	2	1.10.418.10
Domain	LIM	MICAL3 MICAL2	6.97e-03	71	33	2	SM00132
Domain	CH	MICAL3 MICAL2	7.36e-03	73	33	2	PS50021
Domain	CH-domain	MICAL3 MICAL2	7.75e-03	75	33	2	IPR001715
Pubmed	Mutational profiling of poorly differentiated and anaplastic thyroid carcinoma by the use of targeted next-generation sequencing.	TERT PIK3CA	8.73e-07	2	33	2	31230400
Pubmed	High frequency of PIK3CA and TERT promoter mutations in fibromatosis-like spindle cell carcinomas.	TERT PIK3CA	8.73e-07	2	33	2	33952589
Pubmed	Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.	IFNAR1 FOXP3	8.73e-07	2	33	2	19319188
Pubmed	Mutations in the telomerase reverse transcriptase promoter and PIK3CA gene are common events in penile squamous cell carcinoma of Italian and Ugandan patients.	TERT PIK3CA	8.73e-07	2	33	2	35253909
Pubmed	Rapid expansion of Treg cells protects from collateral colitis following a viral trigger.	IFNAR1 FOXP3	2.62e-06	3	33	2	32251280
Pubmed	Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity.	IFNAR1 FOXP3	2.62e-06	3	33	2	34256015
Pubmed	Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism.	TERT PIK3CA	2.62e-06	3	33	2	23624506
Pubmed	[THE SOMATIC MUTATIONS AND ABERRANT METHYLATION AS POTENTIAL GENETIC MARKERS OF URINARY BLADDER CANCER].	TERT PIK3CA	2.62e-06	3	33	2	27455559
Pubmed	Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype.	IFNAR1 FOXP3	2.62e-06	3	33	2	20118405
Pubmed	PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies.	IFNAR1 FOXP3	5.23e-06	4	33	2	39019005
Pubmed	Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation.	IFNAR1 FOXP3	5.23e-06	4	33	2	37478855
Pubmed	IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections.	IFNAR1 FOXP3	5.23e-06	4	33	2	37182738
Pubmed	Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.	MICAL3 MICAL2	5.23e-06	4	33	2	24440334
Pubmed	The MICAL proteins and rab1: a possible link to the cytoskeleton?	MICAL3 MICAL2	5.23e-06	4	33	2	15694364
Pubmed	Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection.	IFNAR1 FOXP3	5.23e-06	4	33	2	24711580
Pubmed	Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation.	PIK3CA FOXP3	5.23e-06	4	33	2	32414808
Pubmed	Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.	IFNAR1 FOXP3	5.23e-06	4	33	2	21804557
Pubmed	Co-infection of mice with SARS-CoV-2 and Mycobacterium tuberculosis limits early viral replication but does not affect mycobacterial loads.	IFNAR1 FOXP3	5.23e-06	4	33	2	37720210
Pubmed	Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis.	IFNAR1 FOXP3	8.72e-06	5	33	2	23913971
Pubmed	MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.	MICAL3 MICAL2	8.72e-06	5	33	2	12110185
Pubmed	Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome.	IFNAR1 FOXP3	8.72e-06	5	33	2	37406138
Pubmed	Interferon-β acts directly on T cells to prolong allograft survival by enhancing regulatory T cell induction through Foxp3 acetylation.	IFNAR1 FOXP3	8.72e-06	5	33	2	35148827
Pubmed	IDO activates regulatory T cells and blocks their conversion into Th17-like T cells.	IFNAR1 FOXP3	1.31e-05	6	33	2	19635913
Pubmed	Association of signaling proteins with a nonmitogenic heterodimeric complex composed of epidermal growth factor receptor and kinase-inactive p185c-neu.	PIK3CA RAPGEF5	1.83e-05	7	33	2	8561895
Pubmed	Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.	IFNAR1 FOXP3	1.83e-05	7	33	2	23791647
Pubmed	Type III interferon drives thymic B cell activation and regulatory T cell generation.	IFNAR1 FOXP3	2.44e-05	8	33	2	36802427
Pubmed	N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations.	TENM4 AQP11	2.44e-05	8	33	2	10224267
Pubmed	Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice.	IFNAR1 FOXP3	2.44e-05	8	33	2	38085267
Pubmed	STING-induced regulatory B cells compromise NK function in cancer immunity.	IFNAR1 FOXP3	3.13e-05	9	33	2	36198789
Pubmed	Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation.	IFNAR1 FOXP3	3.91e-05	10	33	2	24216477
Pubmed	TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells.	IFNAR1 FOXP3	6.77e-05	13	33	2	35417681
Pubmed	Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease.	IFNAR1 FOXP3	6.77e-05	13	33	2	28978474
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PLEKHH1 CACNA1E UNKL YTHDC2	6.90e-05	233	33	4	37704626
Pubmed	Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.	TENM4 TARBP1	1.04e-04	16	33	2	17903297
Pubmed	Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia.	TENM4 GDF10	1.18e-04	17	33	2	15944189
Pubmed	Genetic associations of brain structural networks in schizophrenia: a preliminary study.	PIK3CA DDC	3.99e-04	31	33	2	20691427
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PLEKHH1 MICAL3 TENM4 RAPGEF5	5.78e-04	407	33	4	12693553
Cytoband	11q14.1	TENM4 AQP11	4.24e-04	42	33	2	11q14.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q14	TENM4 AQP11	5.65e-03	156	33	2	chr11q14
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	DNHD1 OR52E5 MICAL2	7.65e-03	564	33	3	chr11p15
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	PLEKHH1 ACOT6	9.12e-03	200	33	2	chr14q24
Cytoband	11p15.4	DNHD1 OR52E5	9.12e-03	200	33	2	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr15q26	RLBP1 DET1	9.65e-03	206	33	2	chr15q26
GeneFamily	LIM domain containing	MICAL3 MICAL2	2.11e-03	59	21	2	1218
Coexpression	OHGUCHI_LIVER_HNF4A_TARGETS_DN	SLC22A25 DDC AQP11 SLC3A1	5.45e-05	171	32	4	M2194
Coexpression	GSE25677_MPL_VS_R848_STIM_BCELL_UP	CACNA1E NDST1 MICAL3 DSE	5.83e-05	174	32	4	M8186
Coexpression	GSE24574_BCL6_LOW_TFH_VS_TCONV_CD4_TCELL_UP	YTHDC2 TENM4 USP9Y IFNAR1	8.90e-05	194	32	4	M8340
Coexpression	GSE40666_UNTREATED_VS_IFNA_STIM_CD8_TCELL_90MIN_DN	PLEKHH1 NDST1 PIK3CA KLHDC3	9.81e-05	199	32	4	M9227
Coexpression	OHGUCHI_LIVER_HNF4A_TARGETS_DN	SLC22A25 DDC AQP11 SLC3A1	1.02e-04	201	32	4	MM1294
Coexpression	HOEK_NK_CELL_2011_2012_TIV_ADULT_1DY_UP	DSE ARL17A	1.30e-04	14	32	2	M41030
Coexpression	JARDIM_PERASSI_TRIPLE_NEGATIVE_BREAST_CANCER_MOUSE_XENOGRAFT_MELATONIN_DN	MICAL2 TARBP1	1.30e-04	14	32	2	MM453
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM4 SYNJ1 TARBP1 AQP11	8.29e-06	175	33	4	1d8aab491dcc27ea5dbfb6462d18ee280b21a05e
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM4 SYNJ1 TARBP1 AQP11	8.29e-06	175	33	4	427a7ee92fe16a90625946492062d37aa0f7235b
Disease	Malformations of Cortical Development	NDST1 PIK3CA	1.03e-04	14	32	2	C1955869
Disease	Cortical Dysplasia	NDST1 PIK3CA	1.03e-04	14	32	2	C0431380
Disease	Malignant neoplasm of breast	DDO MAN2C1 GDF10 TERT MAP3K6 PIK3CA FOXP3	1.26e-04	1074	32	7	C0006142
Disease	Mammary Carcinoma, Human	MAN2C1 GDF10 TERT PIK3CA FOXP3	2.37e-04	525	32	5	C4704874
Disease	Mammary Neoplasms, Human	MAN2C1 GDF10 TERT PIK3CA FOXP3	2.37e-04	525	32	5	C1257931
Disease	Mammary Neoplasms	MAN2C1 GDF10 TERT PIK3CA FOXP3	2.41e-04	527	32	5	C1458155
Disease	Breast Carcinoma	MAN2C1 GDF10 TERT PIK3CA FOXP3	2.65e-04	538	32	5	C0678222
Disease	antiphospholipid antibody measurement	CACNA1E MICAL3	3.37e-04	25	32	2	EFO_0005200
Disease	Pigmented Basal Cell Carcinoma	TERT PIK3CA	4.23e-04	28	32	2	C1368275
Disease	Mental deterioration	TENM4 IFNAR1	4.54e-04	29	32	2	HP_0001268
Disease	Carcinoma, Basal Cell	TERT PIK3CA	4.54e-04	29	32	2	C4721806
Disease	Parkinsonism, Juvenile	SYNJ1 DDC	4.86e-04	30	32	2	C0752105
Disease	hepatitis C (is_marker_for)	TERT FOXP3	6.63e-04	35	32	2	DOID:1883 (is_marker_for)
Disease	hepatocellular carcinoma	DET1 TERT	9.10e-04	41	32	2	EFO_0000182
Disease	Thyroid carcinoma	TERT PIK3CA	1.05e-03	44	32	2	C0549473

Protein segments in the cluster

Peptide	Gene	Start	Entry
PQNRHTFQYRVWHFV	CACNA1E	1461	Q15878
VDAWQQIQTFFHKHL	ACOT6	396	Q3I5F7
HFKIRPLWQHFFQNT	ARL17A	71	Q8IVW1
HCVLWQQLQFIPFFK	DNHD1	351	Q96M86
WHQVRVFHQNVFPNF	DET1	36	Q7L5Y6
SFNFNPHKWLLVNFD	DDC	296	P20711
FSRNNVLHLWPFTIH	MICAL3	121	Q7RTP6
FAFFRNHPATWKNAI	FOXP3	371	Q9BZS1
LAHPFFWSRAKQLQF	ERN2	776	Q76MJ5
QHFHKHQLWPSPFRA	GDF10	316	P55107
AHFWLHFLLQSCQPF	MAP3K6	501	O95382
TFQVQWLHAFLKRNP	IFNAR1	256	P17181
FGNNLNFWLHKLVFV	NDST1	281	P52848
VQRHFNINHFGHPWL	DSE	276	Q9UL01
KALTNQRIGHFFFWH	PIK3CA	656	P42336
IHTQKQWFRETFNHL	DDO	61	Q99489
KLSWNLVNSFPHHTF	MAN2C1	396	Q9NTJ4
LNRHFHDLWKFNPVS	KLHDC3	261	Q9BQ90
FVHPQWKLIHLNGTF	SLC22A25	91	Q6T423
FSRNNVLHLWPFTIH	MICAL2	121	O94851
FWHFDPKRIFHNNSV	OR52E5	311	Q8NH55
NRFFWNQSLHLHLKH	SYNJ1	156	O43426
FHQFSLKENWLQHRG	RAPGEF5	221	Q92565
FIPNHTSDKHIWFQL	SLC3A1	211	Q07837
ILMFSFFLPWLHNNH	AQP11	251	Q8NBQ7
FWRSQVFIDHPVHLK	TENM4	451	Q6N022
FPARFKAIHFIHQPW	RLBP1	231	P12271
HSKNVRFWFTHNVLF	USP9Y	2081	O00507
PQHHFLWYVKQQLQR	PLEKHH1	931	Q9ULM0
QHRPFTCFHWHFLNQ	UNKL	46	Q9H9P5
FQFAHHLLNPWNDNK	YTHDC2	1381	Q9H6S0
WQRIQEHFFFATFHP	TARBP1	1336	Q13395
FHQQVWKNPTFFLRV	TERT	1021	O14746