Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

1.36e-174316920GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

1.00e-118846920GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 ROR2 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4 CHRNA4

4.35e-1013536922GO:0004888
GeneOntologyMolecularFunctionN-succinyltransferase activity

ALAS1 ALAS2

1.18e-052692GO:0016749
GeneOntologyMolecularFunction5-aminolevulinate synthase activity

ALAS1 ALAS2

1.18e-052692GO:0003870
GeneOntologyMolecularFunctionsuccinyltransferase activity

ALAS1 ALAS2

3.52e-053692GO:0016748
GeneOntologyMolecularFunctionodorant binding

OR11L1 OR6N2 OR5B12 OR14C36

9.80e-04127694GO:0005549
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

7.68e-184326920GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

3.20e-174656920GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

7.23e-174856920GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR11L1 EYS OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

1.54e-165826921GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

3.20e-165246920GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

7.27e-165476920GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus

OR11L1 EYS OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

1.11e-147226921GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR11L1 EYS OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4 CHRNA4

2.56e-1210726922GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR11L1 RNF113B OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

2.73e-0913956921GO:0007186
DomainOlfact_rcpt

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR1S1 OR13C2 OR1E1 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

1.23e-143936417IPR000725
DomainGPCR_Rhodpsn_7TM

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR1S1 OR13C2 OR1E1 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

6.31e-116706417IPR017452
Domain7tm_1

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR1S1 OR13C2 OR1E1 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

7.42e-116776417PF00001
DomainG_PROTEIN_RECEP_F1_1

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR1S1 OR13C2 OR1E1 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

8.90e-116856417PS00237
DomainG_PROTEIN_RECEP_F1_2

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR1S1 OR13C2 OR1E1 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

1.02e-106916417PS50262
DomainGPCR_Rhodpsn

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR1S1 OR13C2 OR1E1 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

1.04e-106926417IPR000276
DomainPreseq_ALAS

ALAS1 ALAS2

1.16e-052642PF09029
Domain4pyrrol_synth_NH2levulA_synth

ALAS1 ALAS2

1.16e-052642IPR010961
Domain5aminolev_synth_preseq

ALAS1 ALAS2

1.16e-052642IPR015118
DomainAA_TRANSFER_CLASS_2

ALAS1 ALAS2

1.72e-046642PS00599
DomainAminotrans_II_pyridoxalP_BS

ALAS1 ALAS2

1.72e-046642IPR001917
Domain-

ZC3H10 RNF113B UNKL

3.46e-04406434.10.1000.10
DomainZnF_C3H1

ZC3H10 RNF113B UNKL

5.95e-0448643SM00356
Domainzf-CCCH

ZC3H10 RNF113B UNKL

6.32e-0449643PF00642
DomainZnf_CCCH

ZC3H10 RNF113B UNKL

1.04e-0358643IPR000571
DomainZF_C3H1

ZC3H10 RNF113B UNKL

1.04e-0358643PS50103
DomainAminotransferase_I/II

ALAS1 ALAS2

1.52e-0317642IPR004839
DomainAminotran_1_2

ALAS1 ALAS2

1.52e-0317642PF00155
DomainEGF_1

EYS ADAM19 LAMB3 C1S SVEP1

1.80e-03255645PS00022
DomainEGF-like_CS

EYS ADAM19 LAMB3 C1S SVEP1

2.00e-03261645IPR013032
DomainEGF_2

EYS ADAM19 LAMB3 C1S SVEP1

2.13e-03265645PS01186
DomainhEGF

EYS SVEP1

4.13e-0328642PF12661
DomainEGF_Ca-bd_CS

EYS C1S SVEP1

4.50e-0397643IPR018097
DomainEGF_CA

EYS C1S SVEP1

4.76e-0399643PS01187
DomainASX_HYDROXYL

EYS C1S SVEP1

4.90e-03100643PS00010
DomainSerpin_CS

SERPINB3 SERPINB4

5.37e-0332642IPR023795
DomainEGF-type_Asp/Asn_hydroxyl_site

EYS C1S SVEP1

5.76e-03106643IPR000152
Domain-

ALAS1 ALAS2

6.39e-03356423.90.1150.10
DomainSerpin_dom

SERPINB3 SERPINB4

6.76e-0336642IPR023796
DomainPyrdxlP-dep_Trfase_major_sub2

ALAS1 ALAS2

6.76e-0336642IPR015422
DomainSERPIN

SERPINB3 SERPINB4

7.13e-0337642SM00093
DomainSERPIN

SERPINB3 SERPINB4

7.13e-0337642PS00284
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR11L1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

9.21e-164175619M4072
PathwayREACTOME_SENSORY_PERCEPTION

OR11L1 PLB1 OR2T6 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

1.55e-136365620M41834
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR11L1 OR2T6 OR2T27 OR6N2 OR5B12 OR13C5 OR1Q1 OR1S1 OR13C2 OR1E1 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR1J4

1.27e-123895616M14091
PathwayWP_HEME_BIOSYNTHESIS

ALAS1 ALAS2

5.48e-049562M39470
PathwayKEGG_MEDICUS_REFERENCE_HEME_BIOSYNTHESIS

ALAS1 ALAS2

5.48e-049562M47606
PathwayWP_HEMESYNTHESIS_DEFECTS_AND_PORPHYRIAS

ALAS1 ALAS2

5.48e-049562M45555
PathwayWP_HEME_BIOSYNTHESIS

ALAS1 ALAS2

5.48e-049562MM15895
PathwayWP_GPCRS_OTHER

OR1E1 OR1E3 OR2T1 OR7A2P

5.66e-0496564MM15939
Pubmed

The human olfactory receptor gene family.

OR11L1 OR2T27 OR6N2 OR2T35 OR5B12 OR13C5 OR1Q1 OR2T7 OR1S1 OR13C2 OR1E1 OR1E3 OR1G1 OR2T1 OR2T2 OR14C36 OR2T10 OR7A2P OR1J4

7.28e-19541691914983052
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR11L1 OR2T6 OR6N2 OR2T35 OR5B12 OR1Q1 OR1S1 OR1E1 OR1E3 OR2T1 OR14C36 OR7A2P OR1J4

1.40e-13340691311875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR11L1 OR2T6 OR6N2 OR2T35 OR5B12 OR1Q1 OR1S1 OR1E1 OR1E3 OR2T1 OR14C36 OR7A2P OR1J4

1.40e-13340691311802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR11L1 OR2T6 OR6N2 OR2T35 OR5B12 OR1Q1 OR1S1 OR1E1 OR1E3 OR2T1 OR14C36 OR7A2P OR1J4

1.57e-13343691332295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR11L1 OR2T6 OR6N2 OR2T35 OR5B12 OR1Q1 OR1S1 OR1E1 OR1E3 OR2T1 OR14C36 OR7A2P OR1J4

1.75e-13346691314611657
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR2T6 OR5B12 OR1Q1 OR2T7 OR1E1 OR2T1 OR2T2 OR7A2P OR1J4

5.39e-1021969912213199
Pubmed

Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

OR1Q1 OR1E1 OR1E3 OR2T1 OR7A2P

1.09e-09246959119360
Pubmed

Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

OR1E1 OR1E3 OR1G1

1.22e-06116938004088
Pubmed

Evolution of odorant receptors expressed in mammalian testes.

OR1E1 OR1E3 OR7A2P

2.11e-061369311014824
Pubmed

Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.

OR2T27 OR2T35 OR2T7 OR2T2

2.17e-064669432126975
Pubmed

The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.

SERPINB3 SERPINB4

3.88e-06269215203214
Pubmed

Increased Th1 immune response in SERPINB3 transgenic mice during acute liver failure.

SERPINB3 SERPINB4

3.88e-06269223354406
Pubmed

Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis.

SERPINB3 SERPINB4

3.88e-06269222406480
Pubmed

Recurrent SERPINB3 and SERPINB4 mutations in patients who respond to anti-CTLA4 immunotherapy.

SERPINB3 SERPINB4

3.88e-06269227668655
Pubmed

Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites.

ALAS1 ALAS2

3.88e-0626922780318
Pubmed

Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome.

ALAS1 ALAS2

3.88e-0626922347585
Pubmed

INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells.

EIF3E ATM

3.88e-06269222508697
Pubmed

Two different genes encode delta-aminolevulinate synthase in humans: nucleotide sequences of cDNAs for the housekeeping and erythroid genes.

ALAS1 ALAS2

3.88e-0626922263504
Pubmed

Characterization of novel squamous cell carcinoma antigen-related molecules in mice.

SERPINB3 SERPINB4

3.88e-06269215504361
Pubmed

SCCA2-like serpins mediate genetic predisposition to skin tumors.

SERPINB3 SERPINB4

3.88e-06269212702576
Pubmed

Serpinb3 is overexpressed in the liver in presence of iron overload.

SERPINB3 SERPINB4

3.88e-06269228935635
Pubmed

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.

SERPINB3 SERPINB4

3.88e-06269235022507
Pubmed

Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice.

SERPINB3 SERPINB4

3.88e-06269221403642
Pubmed

SERPINB3/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis.

SERPINB3 SERPINB4

3.88e-06269225111616
Pubmed

Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter.

SERPINB3 SERPINB4

3.88e-06269211267667
Pubmed

Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours.

SERPINB3 SERPINB4

3.88e-06269229491058
Pubmed

Squamous cell carcinoma antigen production in nasal inverted papilloma.

SERPINB3 SERPINB4

3.88e-06269223168150
Pubmed

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.

SERPINB3 SERPINB4

3.88e-06269211863458
Pubmed

The solution structure and heme binding of the presequence of murine 5-aminolevulinate synthase.

ALAS1 ALAS2

3.88e-06269211566198
Pubmed

Serine 254 enhances an induced fit mechanism in murine 5-aminolevulinate synthase.

ALAS1 ALAS2

3.88e-06269219917609
Pubmed

IgM-linked SerpinB3 and SerpinB4 in sera of patients with chronic liver disease.

SERPINB3 SERPINB4

3.88e-06269222808225
Pubmed

Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.

SERPINB3 SERPINB4

3.88e-06269214970861
Pubmed

Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas.

SERPINB3 SERPINB4

3.88e-06269210653592
Pubmed

Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer.

SERPINB3 SERPINB4

3.88e-06269229112685
Pubmed

Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.

SERPINB3 SERPINB4

3.88e-06269210956412
Pubmed

Tumor-related protein, the squamous cell carcinoma antigen binds to the intracellular protein carbonyl reductase.

SERPINB3 SERPINB4

3.88e-06269220428762
Pubmed

SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease.

SERPINB3 SERPINB4

3.88e-06269235874657
Pubmed

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

OR1E1 OR1E3 OR1G1

4.11e-061669310673334
Pubmed

TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target.

TRIM25 TNFAIP3 TRIP12

5.97e-061869334729304
Pubmed

Serpin B3/B4, activated by STAT3, promote survival of squamous carcinoma cells.

SERPINB3 SERPINB4

1.16e-05369219070595
Pubmed

A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases.

SERPINB3 SERPINB4

1.16e-0536929828132
Pubmed

Anti-apoptotic effects of SERPIN B3 and B4 via STAT6 activation in macrophages after infection with Toxoplasma gondii.

SERPINB3 SERPINB4

1.16e-05369222451727
Pubmed

A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.

SERPINB3 SERPINB4

1.16e-0536927724531
Pubmed

Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibition.

ALAS1 ALAS2

1.16e-05369216234850
Pubmed

Differentially expressed proteins in human breast cancer cells sensitive and resistant to paclitaxel.

SERPINB3 SERPINB4

1.16e-05369224898082
Pubmed

A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.

SERPINB3 SERPINB4

1.16e-05369221126757
Pubmed

Porcine odorant-binding protein selectively binds to a human olfactory receptor.

OR1E3 OR1G1

1.16e-05369212379593
Pubmed

Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC).

SERPINB3 SERPINB4

1.16e-05369224635038
Pubmed

Heparin enhances serpin inhibition of the cysteine protease cathepsin L.

SERPINB3 SERPINB4

1.16e-05369219959474
Pubmed

Uteroglobin suppresses SCCA gene expression associated with allergic asthma.

SERPINB3 SERPINB4

1.16e-05369215677460
Pubmed

Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization.

PHEX TCIRG1

1.16e-05369223174213
Pubmed

The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.

OR1E1 OR1E3 OR7A2P

1.29e-052369310706615
Pubmed

A genomic analysis of rat proteases and protease inhibitors.

SPINK13 SERPINB3 SERPINB4

1.29e-052369315060002
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR2T35 OR1E1 OR1E3 OR14C36

1.47e-057469415081110
Pubmed

Functional proteomics mapping of a human signaling pathway.

DGCR2 KMT2B EIF3E TNFAIP3 DAAM1 FHL2 TRIP12 SVEP1

2.23e-0559169815231748
Pubmed

Comprehensive analysis of differential gene expression profiles on D-galactosamine-induced acute mouse liver injury and regeneration.

PRIM2 ATM

2.32e-05469216962228
Pubmed

Odorant receptors govern the formation of a precise topographic map.

OR1E1 OR1E3

2.32e-0546929546391
Pubmed

Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase.

SERPINB3 SERPINB4

2.32e-05469216549498
Pubmed

Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1.

SERPINB3 SERPINB4

2.32e-05469212949073
Pubmed

Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.

SERPINB3 SERPINB4

2.32e-05469221576355
Pubmed

Distribution of olfactory receptor genes in the human genome.

OR1E1 OR1G1 OR2T1

2.36e-05286939500546
Pubmed

Allelic inactivation regulates olfactory receptor gene expression.

OR1E1 OR1E3

3.86e-0556928087849
Pubmed

Fine genetic mapping of the Hyp mutation on mouse chromosome X.

PHEX ALAS2

8.09e-0576928833143
Pubmed

Mouse-human orthology relationships in an olfactory receptor gene cluster.

OR1E1 OR1E3

1.08e-04869211170746
Pubmed

Identification of potential regulatory motifs in odorant receptor genes by analysis of promoter sequences.

OR1E1 OR1E3

1.08e-04869216902085
Pubmed

Sensitivity-dependent hierarchical receptor codes for odors.

OR1E1 OR1E3

1.38e-04969212588732
Pubmed

Gene-expression profiles of peripheral blood mononuclear cell subpopulations in acute graft-vs-host disease following cord blood transplantation.

TNFAIP3 KLF2

1.73e-041069218814951
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

SERPINB3 SERPINB4 ROR2 TRIP12 ZNF654

2.11e-0427269531010829
Pubmed

Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.

SERPINB3 SERPINB4

2.11e-041169215203215
Pubmed

Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding.

OR1E1 OR1E3

2.11e-041169226361056
Pubmed

Erythropoietin contributes to implantation: ectopic hemoglobin synthesis in decidual cells of mice.

ALAS1 ALAS2

2.11e-041169217300687
Pubmed

Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.

OR13C5 OR13C2

2.53e-041269212906860
Pubmed

HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?

PRKCH ATM

2.53e-041269218577246
Pubmed

Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse.

SERPINB3 SERPINB4

2.98e-041369211863365
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DGCR2 KMT2B ZNF827 CHCHD5 MTMR3 LAMB3 UNKL TNFAIP3 ZNF236

3.27e-04110569935748872
Pubmed

Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.

OR1E1 OR1E3

3.48e-04146927528109
Pubmed

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.

TRIM25 TRIP12

3.48e-041469227626314
Pubmed

Quantitative trait loci for steady-state platelet count in mice.

OR1E1 OR1E3

4.01e-041569215520881
Pubmed

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.

SERPINB3 SERPINB4

4.01e-041569230704515
Pubmed

Olfactory receptors and signalling elements in the Grueneberg ganglion.

OR1E1 OR1E3

5.18e-041769216805845
Pubmed

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis.

TRIM25 TRIP12

5.18e-041769237080995
Pubmed

LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5.

TRIM25 SERPINB3

7.95e-042169232939012
Pubmed

Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones.

LAMB3 DNPEP

1.04e-032469224583261
Pubmed

Expression of members of the putative olfactory receptor gene family in mammalian germ cells.

OR1E1 OR1J4

1.13e-03256921370859
Pubmed

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

TNFAIP3 DNPEP

1.32e-032769223740937
Pubmed

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.

OR14C36 OR7A2P

1.32e-032769232061665
Pubmed

Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.

ADAM19 TRIM42

1.42e-032869224322204
Pubmed

Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.

TRIM25 TRIP12

1.42e-032869235474067
Pubmed

Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling.

SERPINB3 SERPINB4

1.74e-033169236971701
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

KMT2B EIF3E ATM FHL2

1.85e-0326269436880596
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

ZC3H10 ZNF827 TNFAIP3 ZNF236

1.93e-0326569419240061
Cytoband1q44

OR11L1 OR2T6 OR2T27 OR2T35 OR2T7 OR2T1 OR2T2 OR14C36 OR2T10

9.37e-141106991q44
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR11L1 OR2T6 OR2T27 OR2T35 OR2T7 OR2T1 OR2T2 OR14C36 OR2T10

3.76e-13128699chr1q44
Cytoband18q21.3

SERPINB3 SERPINB4

1.21e-041169218q21.3
Cytoband17p13.3

OR1E1 OR1E3 OR1G1

3.25e-048869317p13.3
CytobandEnsembl 112 genes in cytogenetic band chr9q31

OR13C5 OR13C2 SVEP1

1.18e-03137693chr9q31
Cytoband9q31.1

OR13C5 OR13C2

1.76e-03416929q31.1
CytobandEnsembl 112 genes in cytogenetic band chr17p13

CFAP52 OR1E1 OR1E3 OR1G1

1.86e-03346694chr17p13
Cytoband14q23.1

PRKCH DAAM1

2.30e-034769214q23.1
GeneFamilyOlfactory receptors, family 1

OR1Q1 OR1S1 OR1E1 OR1E3 OR1G1 OR1J4

2.65e-0940576147
GeneFamilyOlfactory receptors, family 2

OR2T6 OR2T27 OR2T35 OR2T7 OR2T1 OR2T2 OR2T10

6.31e-08113577149
GeneFamilyOlfactory receptors, family 13

OR13C5 OR13C2

2.37e-0323572162
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-2|TCGA-Endometrium / Sample_Type by Project: Shred V9

OR2T6 TRIM42 OR2T35 OR2T7 OR2T2

5.83e-07105685744be8b4255bef3a973db7e4306e52387852e502
ToppCellCOPD-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

SERPINB3 SERPINB4 LAMB3 PRKCH FHL2

7.81e-06178685441d1dba720141891b11f404744c59834d80e6c5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 C1S FHL2 CPED1 SVEP1

7.81e-0617868578a0c6340001a77f5b2d890b6263f574af2e72da
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 C1S FHL2 CPED1 SVEP1

1.04e-0518968571397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 C1S FHL2 CPED1 SVEP1

1.04e-051896854eea4759520c312bd17a681034d8074e47093d2b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND6A EIF3E PRKCH TNFAIP3 ZNF654

1.10e-051916859bb6a6b88f351217455765ba07a6acf11fda98f4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 C1S FHL2 CPED1 SVEP1

1.13e-051926855105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellLPS_only-Stromal_mesenchymal|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S CPED1 SVEP1

1.13e-05192685162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S CPED1 SVEP1

1.13e-051926853d0cb19f037f604253d7d728689aeaa94251e92b
ToppCellLPS-IL1RA-Stromal_mesenchymal|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S CPED1 SVEP1

1.13e-051926854e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S CPED1 SVEP1

1.15e-05193685fb28717fadd06c3840636d25409ce80c9254bd34
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S CPED1 SVEP1

1.18e-051946856e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM19 ROR2 FHL2 CPED1 SVEP1

1.21e-0519568549c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM19 ROR2 FHL2 CPED1 SVEP1

1.21e-05195685dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCellCOVID-19-kidney-Fibroblast-2|kidney / Disease (COVID-19 only), tissue and cell type

ROR2 C1S FHL2 CPED1 SVEP1

1.31e-05198685ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCellBronchial_Biopsy-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

SERPINB3 SERPINB4 EIF3E C1S FHL2

1.37e-052006855ed450e65edff713ad5feba4f6c46209bf471f6e
ToppCell367C-Lymphocytic-ILC-ILC-2|ILC / Donor, Lineage, Cell class and subclass (all cells)

ZNF131 ATM DNPEP

8.19e-05556837916216b3a24f9c6b966aa5392fc2bc43b3d2c4c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

1.30e-04169684a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3-4_RORB_FOLH1B|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OR2T6 OR2T27 OR2T7 OR2T2

1.39e-04172684bbbd013ce554b2f93e463438fed20ec03fe87780
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SERPINB3 SERPINB4 LAMB3 FHL2

1.55e-04177684cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 CPED1 SVEP1

1.65e-0418068408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

OR2T6 TNFAIP3 OR2T10 KLF2

1.65e-04180684cf7d8bf9eee2dfab2c8a6780e296b05ad42041bf
ToppCellCOPD-Epithelial-Basal|World / Disease state, Lineage and Cell class

SERPINB3 SERPINB4 LAMB3 FHL2

1.69e-041816846d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCellControl-Epithelial-Basal|World / Disease state, Lineage and Cell class

SERPINB3 SERPINB4 LAMB3 FHL2

1.72e-04182684759390dde9b18757f7675d13d44c89d0e32f8d93
ToppCellControl-Epithelial-Basal|Control / Disease state, Lineage and Cell class

SERPINB3 SERPINB4 LAMB3 FHL2

1.72e-04182684caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCellCOPD-Epithelial-Basal|COPD / Disease state, Lineage and Cell class

SERPINB3 SERPINB4 LAMB3 FHL2

1.76e-041836840f760e393edc91009bf6c7e02eeac039a1dfb4ed
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

1.80e-04184684c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell3'-Adult-LargeIntestine-Hematopoietic-T_cells-ILC3|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DAPP1 PRKCH TNFAIP3 KLF2

1.80e-041846842f9c5887635185dc1c6ec4e959b6d8a28b0bd020
ToppCellCF|World / Disease state, Lineage and Cell class

ADAM19 LAMB3 TNFAIP3 KLF2

1.91e-04187684eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

1.99e-04189684a153b83314cf52808f685296cff8c95af3f4983d
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

1.99e-04189684e9d5e858e320c6e9913c1ea6a54967d21eda605f
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

PRKCH ATM TNFAIP3 KLF2

1.99e-041896840e8d1be3c406d1a393e18faccfe89116a8f82bcf
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

1.99e-041896842a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

SERPINB3 SERPINB4 LAMB3 FHL2

2.03e-04190684ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPINK13 ROR2 C1S SVEP1

2.03e-04190684efb757f11c2809e66ddb48a5c84f5433f111cb7c
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.03e-0419068445df8fee00f8949937863159d7aa042e72748d9b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.07e-04191684a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.07e-04191684b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 CPED1 SVEP1

2.07e-0419168414057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

2.07e-0419168439092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPINK13 ROR2 CPED1 SVEP1

2.07e-04191684107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCellBasal_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

SERPINB3 SERPINB4 LAMB3 FHL2

2.07e-04191684a98915bad9a4a61dd4cbca798914849b805f4a19
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAM19 EIF3E TNFAIP3 KLF2

2.07e-04191684e94dfd2d8da81bfd16f2f1a4f3ac27b078eeb3ca
ToppCellbackground-B_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ADAM19 DAPP1 C1S KLF2

2.07e-04191684a189fdc9c739bb0801e2f38af0932a1ea615cb34
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SPINK13 ROR2 CPED1 SVEP1

2.07e-04191684bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.07e-041916848f6d592edc32fdb901af30501d4360512334e8c2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

2.07e-04191684ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.11e-041926846f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.11e-04192684bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 C1S CPED1 SVEP1

2.11e-04192684d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCellPND14-Mesenchymal-Mesenchymal_structural|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHEX C1S CPED1 SVEP1

2.11e-0419268425492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.11e-04192684f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.11e-04192684df1545670370fb1010c567cd059c2783eab315f7
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.11e-04192684dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHEX C1S CPED1 SVEP1

2.11e-04192684de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCellIPF-Epithelial-Basal|World / Disease state, Lineage and Cell class

SERPINB3 SERPINB4 LAMB3 FHL2

2.11e-041926849b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.11e-04192684ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.11e-041926840ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.11e-04192684deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SERPINB3 SERPINB4 DAPP1 FHL2

2.16e-04193684463274f394757fb2570ae885d58e1f9fa7e60c4a
ToppCellcellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SERPINB3 SERPINB4 LAMB3 FHL2

2.16e-041936847c34abdcb8839b9fb25457a79af6c5e7b9714b21
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.16e-04193684c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

PHEX ROR2 C1S SVEP1

2.16e-04193684ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.16e-041936845b602b1702283184bd3943c2a6f2290b7c37e407
ToppCellfacs-Bladder-nan-18m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1S TNFAIP3 CPED1 SVEP1

2.20e-04194684f4c9fc53ae31d58096906d9305b0b4082512a7e9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

2.20e-0419468481713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellCOVID-19_Mild-CD4+_Tcm|COVID-19_Mild / Disease condition and Cell class

ADAM19 EIF3E TNFAIP3 KLF2

2.20e-041946843be2b1c81e668ffdf593ff41d3ba211c26d77671
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

2.20e-04194684cf0244a29934e515446ac917d3c30672b460fb04
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.20e-0419468460622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

C1S DAAM1 CPED1 SVEP1

2.20e-0419468490efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.20e-04194684e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

C1S DAAM1 CPED1 SVEP1

2.20e-04194684df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PHEX ROR2 C1S SVEP1

2.20e-0419468489b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

2.20e-04194684ba7f971fb9a19423602da60770f23d9fead4a451
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

2.20e-04194684627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHEX C1S CPED1 SVEP1

2.24e-04195684cbe518b465b4ef32797ae6b608219207c08493df
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells-SELL+_CD8_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EIF3E PRKCH TNFAIP3 KLF2

2.24e-0419568482561f6ed75ee33c2581fb25bd0997a9f0538cd8
ToppCelldistal-Epithelial-Differentiating_Basal-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SERPINB3 SERPINB4 LAMB3 FHL2

2.24e-041956843fe6e49a9161fc9e5160251e6932cb5378175a54
ToppCellPND03-Mesenchymal-Mesenchymal_structural|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PHEX C1S CPED1 SVEP1

2.24e-04195684136b06b0931a69b1241101f68c01c44c70365fd9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.24e-04195684cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.24e-041956843c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.24e-04195684783bfa8110161cbd6def50ce849cae676c39c458
ToppCellCOVID-19-kidney-Fibroblast-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ROR2 FHL2 CPED1 SVEP1

2.24e-041956843d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCelldroplet-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1S CPED1 SVEP1 KLF2

2.24e-04195684095b8e0be385b6390420589124a95fa4ba3682ab
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

SERPINB3 SERPINB4 LAMB3 FHL2

2.29e-041966843b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

2.29e-04196684fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 FHL2 CPED1 SVEP1

2.29e-04196684802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.29e-041966843a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD8-Tnaive/CM_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

EIF3E ATM TNFAIP3 KLF2

2.29e-04196684e7fd508cb9a8a5b3d1c0247dabf486c4434b5e94
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.29e-04196684bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCelldistal-3-Epithelial-Differentiating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SERPINB3 SERPINB4 LAMB3 FHL2

2.29e-0419668477635a0f86910c4019d3370e9c8ba41de176bcf3
ToppCellcellseq-Epithelial-Epithelial_Airway|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SERPINB3 SERPINB4 LAMB3 FHL2

2.29e-04196684faa39c567f24403e511b240c1d1a654ffadd8473
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADAM19 DAPP1 OR2T10 CPED1

2.29e-04196684de43dd0697e1daf4d50800957cf0b27b54a7a333
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.33e-0419768409946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCellBasal_cells|World / lung cells shred on cell class, cell subclass, sample id

SERPINB3 SERPINB4 LAMB3 FHL2

2.33e-0419768424360b660000bdfb999d58fbf4e29585a97e1785
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.33e-04197684ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1S FHL2 CPED1 SVEP1

2.33e-0419768437f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell3'-Broncho-tracheal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SERPINB3 SERPINB4 LAMB3 FHL2

2.33e-041976845d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ROR2 C1S CPED1 SVEP1

2.33e-0419768444673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SERPINB3 SERPINB4 LAMB3 FHL2

2.33e-04197684de772bd2b4cda843777ac879b1087e6444199dfb
DrugAC1L9T6Z

ALAS1 ALAS2 ATM

3.95e-0611673CID000455606
Drug2-amino-3-ketoadipate

ALAS1 ALAS2

8.53e-062672CID000440714
Drugpregnanedione

ALAS1 ALAS2

8.53e-062672CID000135006
DrugMetformin hydrochloride [1115-70-4]; Up 200; 24.2uM; PC3; HT_HG-U133A

KMT2B C1S PRKCH ATM ZNF236 ZNF654

2.23e-051936761816_UP
DrugNadolol [42200-33-9]; Up 200; 13uM; PC3; HT_HG-U133A

PHEX ADAM19 OR1G1 ZNF236 SVEP1 DNPEP

2.30e-051946764021_UP
DiseaseDystonia, Limb

KMT2B CHRNA4

5.42e-0417602C0751093
DiseaseDystonia, Diurnal

KMT2B CHRNA4

5.42e-0417602C0393610
DiseaseDystonia, Paroxysmal

KMT2B CHRNA4

6.09e-0418602C0393588
DiseaseDystonia

KMT2B ATM CHRNA4

7.25e-0486603C0013421
Diseaseeosinophil percentage of leukocytes

PLB1 ADAM19 KMT2B C1S ATM TNFAIP3 KLF2

7.75e-04746607EFO_0007991
DiseaseGranulomatous Slack Skin

ATM TNFAIP3

9.15e-0422602C0376407
DiseaseAdenocarcinoma of large intestine

ROR2 PRKCH ATM

9.98e-0496603C1319315
DiseaseLymphoma, T-Cell, Cutaneous

ATM TNFAIP3

1.00e-0323602C0079773
Diseasetobacco smoke exposure measurement

FHL2 CHRNA4

1.09e-0324602EFO_0009115
Diseaselung small cell carcinoma (is_implicated_in)

LAMB3 ATM

1.49e-0328602DOID:5409 (is_implicated_in)
Diseasestimulant use measurement

EYS RCBTB2

1.49e-0328602EFO_0600076
DiseaseLymphoma

ATM TNFAIP3

3.02e-0340602C0024299
DiseaseAutoimmune Diseases

C1S TNFAIP3

3.32e-0342602C0004364
Diseasenasopharynx carcinoma (is_marker_for)

ATM TNFAIP3

3.48e-0343602DOID:9261 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
CSIDVTFFPFDQQNC

CHRNA4

161

P43681
EFIFAPRLDNLHSCF

DNPEP

266

Q9ULA0
TFHRCRFCFQLLTFD

CPED1

351

A4D0V7
HICFEGQCRNTSFFE

ADAM19

636

Q9H013
DLEEFCFRFCINHLT

RCBTB2

506

O95199
QLSFCTDLEIPHFFC

OR7A2P

166

Q8NGA2
HTFQNECFFCVEQRE

SPINK13

66

Q1W4C9
FCNHNTLPHFFCDLA

OR1S1

181

Q8NH92
FPFCNSREINHFFCE

OR2T1

216

O43869
SFPFCRSREINHFFC

OR2T2

166

Q6IF00
LTNRFFCNCEPEYHG

EYS

946

Q5T1H1
SAECNFCRRPLHFEV

ALAS1

606

P13196
ANTLFQCVCYHPEEF

CFAP52

501

Q8N1V2
FCRSNVIHQFFCDIP

OR14C36

166

Q8NHC7
LPFCASHQINHFFCE

OR2T6

166

Q8NHC8
QFPFCASREINHFFC

OR2T7

156

P0C7T2
QSFCDRFLNSPLFHA

CSNKA2IP

81

A0A1B0GTH6
ACFPFAFCRDCQFLE

PMS2P5

76

A8MQ11
CCFTLPRESAEAFHN

LACC1

341

Q8IV20
NAARFINHSCEPNCF

KMT2B

2646

Q9UMN6
LDFCGRNQINHFFCD

OR11L1

166

Q8NGX0
FPFCASREINHFFCE

OR2T27

166

Q8NH04
LPFCRNNIINHFTCE

OR13C5

166

Q8NGS8
FPFCRSREINHFFCE

OR2T35

166

Q8NGX2
LPFCRNNIINHFTCE

OR13C2

166

Q8NGS9
FCRSNVVEHFFCDAP

OR5B12

166

Q96R08
SVAACNFCRRPVHFE

ALAS2

551

P22557
LSFCADNTIPHFFCD

OR1J4

166

Q8NGS1
LSFCANHEIPHFFCD

OR1G1

166

P47890
FPFCRSHEIQHFFCE

OR2T10

166

Q8NGZ9
DCGFSLNHPNQFFCE

PRIM2

436

P49643
LPFCAYNEIQHIFCD

OR6N2

166

Q8NGY6
ISFIFCCFRNNDHPE

DAAM1

11

Q9Y4D1
PANLDSESEHFFRCC

ATM

1886

Q13315
QACAQPFEAFEECLR

CHCHD5

56

Q9BSY4
SQERVNCFCLVFPFR

DAPP1

221

Q9UN19
TDFVDVPCSHFCNNF

C1S

136

P09871
VHEVDIFRCFCPVFL

DENND6A

266

Q8IWF6
ARLFIFETFCRIHQC

EIF3E

336

P60228
FHCSQCRNSLVDKPF

FHL2

66

Q14192
VFCAQLQCFHFPTLR

DGCR2

231

P98153
CHPCFQTYDADLREQ

LAMB3

581

Q13751
AALFEACCSDRIQPF

PPP6R2

616

O75170
DCVHQLQRQFPCSFE

MTMR3

481

Q13615
LSFCAENVIPHFFCD

OR1E3

166

Q8WZA6
LCFCADNVIPHFFCD

OR1E1

166

P30953
LIFCADNRIPHFFCD

OR1Q1

166

Q15612
ENFFILICPVCDRSH

TRIM42

181

Q8IWZ5
EIPFRCFICRQAFQN

RNF113B

251

Q8IZP6
DQCSQFAIPSFCHFV

ROR2

221

Q01974
CDFCNDLVHYSPQNF

PLB1

516

Q6P1J6
SQVFHECFFNPCHNS

SVEP1

1191

Q4LDE5
EEFHCNHPFLFFIRQ

SERPINB3

361

P29508
FATVCQECTDFHFPR

C12orf4

346

Q9NQ89
PFICHVCNKAFRTNF

ZBTB21

936

Q9ULJ3
TNLHCILDFFCEFSE

NAA35

346

Q5VZE5
FRTCQFCPQFREIIH

TNFAIP3

51

P21580
KCSQHNRLREFFCPE

TRIM25

156

Q14258
NRLREFFCPEHSECI

TRIM25

161

Q14258
FCLHFNCNESFKLPF

ZNF654

816

Q8IZM8
IFQAQCSFPECHELF

ZNF654

841

Q8IZM8
NLSVDPCDNFFRFAC

PHEX

71

P78562
EEFCCNHPFLFFIRQ

SERPINB4

361

P48594
FRTEQCPLFSQHKCA

UNKL

31

Q9H9P5
HQDRGETFQCQLCPF

ZNF827

426

Q17R98
HRCDQCPQTFNVEFN

ZNF236

66

Q9UL36
QVEHCRQRDFLPFVC

ZFAND1

11

Q8TCF1
FECPNCHERFARNST

ZNF131

356

P52739
FIFCHDFQNKECSRP

ZC3H10

76

Q96K80
ANCCQSITPDEFHFV

TRIP12

586

Q14669
TDCFHCHVFPFLQQE

TCIRG1

236

Q13488
PFQCHLCDRAFSRSD

KLF2

331

Q9Y5W3
RNHPFLTQLFCCFQT

PRKCH

411

P24723