Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cell cortex region	PKD2 BSN UNC13A	1.81e-04	45	51	3	GO:0099738
MousePheno	achlorhydria	EZR SLC4A2	4.53e-05	4	39	2	MP:0008003
Domain	PNMA	ZCCHC18 ZCCHC12	3.51e-04	11	48	2	PF14893
Domain	PNMA	ZCCHC18 ZCCHC12	3.51e-04	11	48	2	IPR026523
Domain	Acyltransferase	AGPAT3 GNPAT	7.58e-04	16	48	2	PF01553
Domain	PlsC	AGPAT3 GNPAT	8.58e-04	17	48	2	SM00563
Domain	DUF1605	DHX16 DHX37	8.58e-04	17	48	2	IPR011709
Domain	Plipid/glycerol_acylTrfase	AGPAT3 GNPAT	8.58e-04	17	48	2	IPR002123
Domain	OB_NTP_bind	DHX16 DHX37	8.58e-04	17	48	2	PF07717
Domain	HA2	DHX16 DHX37	9.64e-04	18	48	2	SM00847
Domain	HA2	DHX16 DHX37	9.64e-04	18	48	2	PF04408
Domain	Helicase-assoc_dom	DHX16 DHX37	9.64e-04	18	48	2	IPR007502
Domain	-	ZCCHC18 ZCCHC12	2.02e-03	26	48	2	4.10.60.10
Domain	ZF_CCHC	ZCCHC18 ZCCHC12	3.65e-03	35	48	2	PS50158
Domain	DNA/RNA_helicase_DEAH_CS	DHX16 DHX37	3.65e-03	35	48	2	IPR002464
Domain	DEAH_ATP_HELICASE	DHX16 DHX37	4.29e-03	38	48	2	PS00690
Domain	ZnF_C3H1	ZRSR2P1 ZC3H18	6.77e-03	48	48	2	SM00356
Domain	ZnF_C2HC	ZCCHC18 ZCCHC12	8.81e-03	55	48	2	SM00343
Domain	Znf_CCHC	ZCCHC18 ZCCHC12	8.81e-03	55	48	2	IPR001878
Domain	Znf_CCCH	ZRSR2P1 ZC3H18	9.76e-03	58	48	2	IPR000571
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	DHX16 EZR SAFB RBM33 SUPT6H DROSHA GIGYF2 ZC3H18 EIF3A LARP1B DYNC1H1	2.49e-08	807	52	11	22681889
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX16 ERBB3 ZNF609 DROSHA DHX37 GIGYF2 SIN3A CLSPN SLC4A2 GNPAT	3.79e-08	650	52	10	38777146
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX16 ZNF512B EZR SAFB SUPT6H DROSHA DHX37 CECR2 FNBP4 ZC3H18 UNC13A DYNC1H1	5.07e-08	1082	52	12	38697112
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	DHX16 SAFB PHF3 SUPT6H GIGYF2 ZC3H18 HDGFL2	9.51e-08	251	52	7	28077445
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	DHX16 SAFB RBM33 SUPT6H FNBP4 HDGFL2	1.65e-07	163	52	6	22113938
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	SUPT6H EIF3A CLSPN DYNC1H1	5.25e-07	43	52	4	34672947
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	ZNF512B ZNF609 SAFB RBM33 PHF3 FNBP4 GIGYF2 ZDBF2 ZC3H18 HDGFL2	1.28e-06	954	52	10	36373674
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DHX16 SAFB PHF3 FNBP4 GIGYF2 ZC3H18 SIN3A PPL CLASRP	2.00e-06	774	52	9	15302935
Pubmed	Identification of proteins that interact with murine cytomegalovirus early protein M112-113 in brain.	ZCCHC18 ZCCHC12	2.19e-06	2	52	2	22340173
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ZNF512B SAFB PHF3 DROSHA DHX37 FNBP4 GIGYF2 ZC3H18 EIF3A	4.16e-06	847	52	9	35850772
Pubmed	SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA.	SAFB DROSHA	6.57e-06	3	52	2	38722021
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DHX16 EZR RBM33 PHF3 FNBP4 HDGFL2 DYNC1H1	1.01e-05	506	52	7	30890647
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	ZCCHC18 ZRSR2P1 SAFB ZCCHC12 SUPT6H GPANK1	1.31e-05	347	52	6	16033648
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	SAFB FNBP4 GIGYF2 ZC3H18 EIF3A	1.31e-05	202	52	5	24639526
Pubmed	Paralog Studies Augment Gene Discovery: DDX and DHX Genes.	DHX16 DHX37	1.31e-05	4	52	2	31256877
Pubmed	Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator.	ZCCHC18 ZCCHC12	1.31e-05	4	52	2	19578717
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF512B ZNF609 SUPT6H CECR2 KIF16B FNBP4 BSN	1.34e-05	529	52	7	14621295
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ERBB3 SAFB PHF3 ZC3H18 EIF3A CLASRP	1.63e-05	361	52	6	26167880
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ZNF512B ZNF609 SAFB PHF3 SUPT6H FNBP4 ZC3H18 SIN3A HDGFL2 CLASRP	1.87e-05	1294	52	10	30804502
Pubmed	DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.	RBM33 EIF3A SIN3A	1.99e-05	35	52	3	24515614
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DHX16 EPS15 RBM33 DROSHA GIGYF2 CLSPN CLASRP GNPAT NUFIP1	2.11e-05	1038	52	9	26673895
Pubmed	Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling.	ZCCHC18 ZCCHC12	2.19e-05	5	52	2	18160706
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	EPS15 KIF16B FNBP4 PPL	2.36e-05	111	52	4	22558309
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RBM33 SUPT6H DROSHA ZDBF2 ZC3H18 BSN CLSPN	2.64e-05	588	52	7	38580884
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZNF512B EPS15 DROSHA FNBP4 SDK1 DYNC1H1 PPL	2.72e-05	591	52	7	15231748
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ZNF512B SAFB SUPT6H FNBP4 ZC3H18 EIF3A HDGFL2	3.16e-05	605	52	7	28977666
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	DHX16 ZNF512B PHF3 DHX37 ZC3H18 SIN3A HDGFL2	3.26e-05	608	52	7	36089195
Pubmed	Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.	BSN UNC13A	3.28e-05	6	52	2	14734538
Pubmed	XLMR candidate mouse gene, Zcchc12 (Sizn1) is a novel marker of Cajal-Retzius cells.	ZCCHC18 ZCCHC12	3.28e-05	6	52	2	21172456
Pubmed	A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1.	BSN UNC13A	3.28e-05	6	52	2	19812333
Pubmed	The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting.	BSN UNC13A	3.28e-05	6	52	2	31787876
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	ZRSR2P1 SAFB SUPT6H ZC3H18 HDGFL2	3.71e-05	251	52	5	31076518
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF512B ZNF609 TCHH DROSHA CECR2 ZC3H18 SIN3A CLSPN NUFIP1	3.71e-05	1116	52	9	31753913
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	DHX37 GIGYF2 EIF3A	4.00e-05	44	52	3	26471122
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	EPS15 ZNF609 SIN3A BSN CLSPN DYNC1H1	4.34e-05	430	52	6	35044719
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	DHX16 DHX37 FNBP4 UNC13A	4.39e-05	130	52	4	12421765
Pubmed	Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation.	ZCCHC18 ZCCHC12	4.58e-05	7	52	2	28819210
Pubmed	SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation.	ZCCHC18 ZCCHC12	4.58e-05	7	52	2	19416967
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	ZNF512B ZNF609 RBM33 PHF3 SIN3A	5.06e-05	268	52	5	33640491
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 PHF3 SUPT6H DHX37 GIGYF2 ZC3H18 DYNC1H1	5.12e-05	653	52	7	22586326
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	EZR EPS15 ZNF609 SAFB PHF3 CCDC102A	5.19e-05	444	52	6	34795231
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	DHX16 RBM33 PHF3 ZC3H18 HDGFL2	6.55e-05	283	52	5	30585729
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	SUPT6H CECR2 ZC3H18 SIN3A HDGFL2 CLASRP	7.01e-05	469	52	6	27634302
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	SAFB RBM33 ZC3H18 HDGFL2	7.27e-05	148	52	4	32538781
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DHX16 EZR SAFB PHF3 DHX37 ZC3H18 EIF3A DYNC1H1 PPL	9.27e-05	1257	52	9	36526897
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RBM33 DHX37 FNBP4 GIGYF2 CCDC57 HDGFL2	9.64e-05	497	52	6	36774506
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	EPS15 ZNF609 RBM33 PHF3 ZDBF2 CLSPN SLC4A2	1.05e-04	733	52	7	34672954
Pubmed	Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium.	ZCCHC18 ZCCHC12	1.20e-04	11	52	2	29661797
Pubmed	A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells.	EZR PPL	1.20e-04	11	52	2	14625392
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DHX16 SAFB PHF3 SUPT6H ZC3H18 EIF3A SIN3A HDGFL2	1.23e-04	1014	52	8	32416067
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	TCHH LARP1B SDK1 PPL	1.24e-04	170	52	4	23314748
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DHX16 ZNF512B EZR SAFB SUPT6H GIGYF2 EIF3A DYNC1H1	1.31e-04	1024	52	8	24711643
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EZR SAFB PHF3 SIN3A DYNC1H1	1.38e-04	332	52	5	32786267
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	DHX16 SAFB PHF3 ZC3H18	1.65e-04	183	52	4	28186131
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	EZR PHF3 FNBP4 GIGYF2 SIN3A DYNC1H1	1.66e-04	549	52	6	38280479
Pubmed	The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.	EIF3A SIN3A	1.69e-04	13	52	2	12124384
Pubmed	Large-scale concatenation cDNA sequencing.	EPS15 SUPT6H PKD2 CCDC57 SDK1 GNPAT	1.99e-04	568	52	6	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	EPS15 SUPT6H PKD2 CCDC57 SDK1 GNPAT	2.10e-04	574	52	6	8619474
Pubmed	Huntingtin interacting proteins are genetic modifiers of neurodegeneration.	EZR FNBP4 DYNC1H1 PPL	2.19e-04	197	52	4	17500595
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	EZR SUPT6H FNBP4 GIGYF2 ZC3H18 EIF3A SIN3A HDGFL2 DYNC1H1	2.26e-04	1415	52	9	28515276
Pubmed	Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.	EIF3A SIN3A	2.27e-04	15	52	2	9804427
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DHX16 EZR SAFB SUPT6H DHX37 GIGYF2 EIF3A BSN DYNC1H1	2.38e-04	1425	52	9	30948266
Pubmed	Human transcription factor protein interaction networks.	ZNF512B ZNF609 RBM33 DHX37 GIGYF2 ZC3H18 EIF3A SIN3A DYNC1H1	2.43e-04	1429	52	9	35140242
Pubmed	Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.	EIF3A SIN3A	2.60e-04	16	52	2	11102443
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	DHX16 EZR EPS15 ZNF609 EIF3A DYNC1H1 PPL NUFIP1	2.97e-04	1155	52	8	20360068
Pubmed	Defining the membrane proteome of NK cells.	EZR EPS15 AGPAT3 GIGYF2 EIF3A DYNC1H1 SLC4A2 GNPAT	3.20e-04	1168	52	8	19946888
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	EIF3A SIN3A	3.30e-04	18	52	2	10444591
Pubmed	The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.	EIF3A SIN3A	3.30e-04	18	52	2	9790534
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	PHF3 GIGYF2	3.30e-04	18	52	2	25363768
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TMX2 EPS15 RBM33 PHF3 SUPT6H DROSHA WHAMM EIF3A HDGFL2	3.42e-04	1497	52	9	31527615
Pubmed	Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice.	ZCCHC18 ZCCHC12	3.69e-04	19	52	2	37389991
Pubmed	mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.	BSN UNC13A	4.09e-04	20	52	2	23791195
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	SAFB RBM33 CECR2 FNBP4 HDGFL2	4.31e-04	425	52	5	24999758
Pubmed	LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5.	EZR GOLGA6L2	4.52e-04	21	52	2	32939012
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZNF512B EPS15 SAFB GIGYF2 EIF3A SIN3A HDGFL2	4.60e-04	934	52	7	33916271
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	SAFB SUPT6H GPANK1 DYNC1H1 CLASRP GNPAT	4.79e-04	670	52	6	22990118
Pubmed	ISL1 controls pancreatic alpha cell fate and beta cell maturation.	ZCCHC18 ZCCHC12	4.97e-04	22	52	2	36899442
Pubmed	Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.	ZCCHC18 ZCCHC12	5.44e-04	23	52	2	37071993
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF512B EZR ERBB3 ZCCHC12 DROSHA WHAMM DYNC1H1 NUFIP1	6.02e-04	1285	52	8	35914814
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	EZR SAFB RBM33 FNBP4 EIF3A CLASRP	6.08e-04	701	52	6	30196744
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	SAFB PHF3 SUPT6H DHX37 EIF3A SIN3A CLSPN	6.46e-04	989	52	7	36424410
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	EZR SAFB DROSHA EIF3A LARP1B DYNC1H1	6.69e-04	714	52	6	28302793
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	ZNF609 SAFB RBM33 PHF3 HDGFL2	6.93e-04	472	52	5	38943005
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ZNF609 RBM33 PHF3 DHX37 GIGYF2 LARP1B	7.19e-04	724	52	6	36232890
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	EZR ZNF609 GOLGA6L2 AGPAT3 PKD2 GIGYF2 DYNC1H1 CLASRP	7.22e-04	1321	52	8	27173435
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	DHX16 EZR DROSHA EIF3A DYNC1H1	7.27e-04	477	52	5	31300519
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	SAFB EIF3A SIN3A DYNC1H1	7.28e-04	271	52	4	25737280
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	SAFB GIGYF2 EIF3A LARP1B	7.58e-04	274	52	4	34244482
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	SUPT6H PKD2	8.08e-04	28	52	2	24462114
Pubmed	Novel genes differentially expressed in cortical regions during late neurogenesis.	ZCCHC18 ZCCHC12	8.08e-04	28	52	2	17614941
Pubmed	Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons.	ZCCHC18 ZCCHC12	8.67e-04	29	52	2	31491374
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	EZR EPS15 SAFB ZC3H18 EIF3A SIN3A HDGFL2 PPL	9.01e-04	1367	52	8	32687490
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	EPS15 SAFB RBM33	9.86e-04	130	52	3	35545047
Pubmed	STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.	EPS15 DYNC1H1	9.92e-04	31	52	2	28089446
Pubmed	The synaptic vesicle cycle.	BSN UNC13A	9.92e-04	31	52	2	15217342
Pubmed	Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.	BSN DYNC1H1	1.19e-03	34	52	2	25915474
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	EZR RBM33 EIF3A HDGFL2 DYNC1H1	1.24e-03	538	52	5	28524877
Pubmed	Development and application of a DNA microarray-based yeast two-hybrid system.	TMX2 DHX37 SLC4A2	1.25e-03	141	52	3	23275563
Pubmed	eXPRESSION: an in silico tool to predict patterns of gene expression.	ZCCHC18 ZCCHC12	1.26e-03	35	52	2	15939374
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EZR SAFB EIF3A CFAP210 BSN CCDC57 HDGFL2 PPL	1.27e-03	1442	52	8	35575683
Interaction	DHX40 interactions	DHX16 SAFB RBM33 SUPT6H DROSHA ZDBF2 ZC3H18 CLSPN	1.95e-07	249	51	8	int:DHX40
Interaction	ITSN1 interactions	EZR EPS15 KIF16B FNBP4 WHAMM DYNC1H1 PPL	3.82e-06	259	51	7	int:ITSN1
Interaction	MECP2 interactions	DHX16 ZNF512B EZR SAFB SUPT6H DROSHA DHX37 CECR2 FNBP4 ZC3H18 SIN3A UNC13A DYNC1H1	1.34e-05	1287	51	13	int:MECP2
Interaction	DDX23 interactions	DHX16 ZNF512B SAFB PHF3 SUPT6H ZC3H18 HDGFL2 CLASRP	2.53e-05	480	51	8	int:DDX23
Interaction	PYHIN1 interactions	DHX16 SAFB PHF3 SUPT6H GIGYF2 ZC3H18 HDGFL2	3.11e-05	358	51	7	int:PYHIN1
Interaction	U2AF2 interactions	DHX16 EZR ZRSR2P1 SAFB GIGYF2 ZC3H18 EIF3A DYNC1H1 CLASRP	3.27e-05	651	51	9	int:U2AF2
Interaction	SNRPB interactions	SAFB PHF3 SUPT6H FNBP4 GIGYF2 ZC3H18 DYNC1H1 SERTAD3	4.29e-05	517	51	8	int:SNRPB
Interaction	KRTAP13-3 interactions	SUPT6H CCDC102B CCDC57 GPANK1	6.33e-05	85	51	4	int:KRTAP13-3
Interaction	PTH1R interactions	TMX2 AGPAT3 GPANK1 SLC4A2	7.25e-05	88	51	4	int:PTH1R
Interaction	ZFC3H1 interactions	ZC3H18 CARNMT1 LARP1B CCDC57 DYNC1H1	1.03e-04	185	51	5	int:ZFC3H1
Interaction	SNRPC interactions	DHX16 SAFB PHF3 SUPT6H GIGYF2 ZC3H18 GNPAT	1.14e-04	440	51	7	int:SNRPC
Interaction	ZNF330 interactions	DHX16 ZNF512B PHF3 SUPT6H DHX37 ZC3H18 SIN3A	1.24e-04	446	51	7	int:ZNF330
GeneFamily	Paraneoplastic Ma antigens	ZCCHC18 ZCCHC12	1.98e-04	11	35	2	671
GeneFamily	DEAH-box helicases	DHX16 DHX37	4.29e-04	16	35	2	500
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	ZCCHC18 ZCCHC12	1.06e-03	25	35	2	74
GeneFamily	Zinc fingers CCCH-type	ZRSR2P1 ZC3H18	2.08e-03	35	35	2	73
GeneFamily	RNA binding motif containing	ZRSR2P1 SAFB RBM33	8.00e-03	213	35	3	725
GeneFamily	EF-hand domain containing	EPS15 TCHH PKD2	8.62e-03	219	35	3	863
Coexpression	GSE40493_BCL6_KO_VS_WT_TREG_UP	EZR SUPT6H CECR2 EIF3A DYNC1H1 SERTAD3	1.37e-06	177	52	6	M9401
Coexpression	OCONNOR_PBMC_MENVEO_ACWYVAX_AGE_30_70YO_7DY_AFTER_SECOND_DOSE_VS_7DY_AFTER_FIRST_DOSE_UP	ZNF512B SUPT6H WHAMM DYNC1H1 CLASRP	1.05e-05	146	52	5	M41190
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#5_top-relative-expression-ranked_1000	EPS15 GIGYF2 CARNMT1 CFAP210 LARP1B AK7	2.03e-05	230	52	6	gudmap_developingGonad_e18.5_ovary_1000_k5
ToppCell	control-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PKD2 CLASRP CCDC102A NUFIP1	2.55e-05	146	52	4	69e9c1ec6eec1151290227902e75e77a4aecc8db
ToppCell	normal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|normal_Lung / Location, Cell class and cell subclass	EZR ZDBF2 CLSPN SLC4A2	4.21e-05	166	52	4	ff32422390852546e0cb216192452e9c47bd9509
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ERBB3 ZBED2 BSN AK7	5.41e-05	177	52	4	0417460bdb012bc43d7254377fa53d79cdab3f34
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZCCHC12 CCDC171 SDK1 UNC13A	5.90e-05	181	52	4	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	moderate-Epithelial-Ciliated-diff\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	EZR ANKRD66 CFAP210 AK7	7.27e-05	191	52	4	6cdc6a0c0a1ce5a1ef550832319847f62e718975
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated-diff\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EZR ANKRD66 CFAP210 AK7	7.27e-05	191	52	4	3e84c453e8a151c42808fe2935f1d732e180008c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	EZR PHF3 FNBP4 CFAP210	7.27e-05	191	52	4	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ERBB3 RBM33 PHF3 SDK1	7.41e-05	192	52	4	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ZCCHC12 ZDBF2 BSN UNC13A	7.41e-05	192	52	4	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZCCHC12 ZDBF2 BSN UNC13A	7.87e-05	195	52	4	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	critical-Epithelial-Ciliated-diff\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	EZR ANKRD66 CFAP210 AK7	8.19e-05	197	52	4	34fa5568eb5e5f1ee5d4c7e5d237997eaca573ae
ToppCell	NS-critical-d_0-4-Epithelial-Ciliated-diff\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EZR ANKRD66 CFAP210 AK7	8.19e-05	197	52	4	62e20ef825b92908d7732aa625dcff7b95ef6ca8
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated-diff\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EZR ANKRD66 CFAP210 AK7	8.19e-05	197	52	4	009dc732c43bfdc0d5a662b2c7d1a7a86b0d1d24
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RBM33 PHF3 EIF3A DYNC1H1	8.68e-05	200	52	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal\|6m / Sample Type, Dataset, Time_group, and Cell type.	ERBB3 ANKRD66 CFAP210 AK7	8.68e-05	200	52	4	13ec8afea86e4a10599c924871ba4e325b0a8013
Disease	anxiety disorder, stress-related disorder	GIGYF2 SDK1	1.62e-04	12	47	2	EFO_0006788, EFO_0010098
Disease	Microcephaly	TMX2 SIN3A DYNC1H1	1.69e-04	67	47	3	C0025958
Disease	Severe Congenital Microcephaly	SIN3A DYNC1H1	1.12e-03	31	47	2	C3853041
Disease	Microlissencephaly	SIN3A DYNC1H1	1.27e-03	33	47	2	C1956147
Disease	Degenerative Diseases, Central Nervous System	AGPAT3 PKD2	1.77e-03	39	47	2	C0270715
Disease	Degenerative Diseases, Spinal Cord	AGPAT3 PKD2	1.77e-03	39	47	2	C0751733
Disease	Neurodegenerative Disorders	AGPAT3 PKD2	1.77e-03	39	47	2	C0524851
Disease	epilepsy (implicated_via_orthology)	BSN UNC13A DYNC1H1	2.25e-03	163	47	3	DOID:1826 (implicated_via_orthology)
Disease	triacylglycerol 54:4 measurement	AGPAT3 SDK1	2.46e-03	46	47	2	EFO_0010422
Disease	developmental disorder of mental health (implicated_via_orthology)	GIGYF2 SIN3A	2.78e-03	49	47	2	DOID:0060037 (implicated_via_orthology)
Disease	Prostatic Neoplasms	EZR ERBB3 EIF3A PPL SLC4A2	2.90e-03	616	47	5	C0033578
Disease	Malignant neoplasm of prostate	EZR ERBB3 EIF3A PPL SLC4A2	2.90e-03	616	47	5	C0376358
Disease	hair morphology measurement	TCHH CCDC102B	3.37e-03	54	47	2	EFO_0007821
Disease	Nasal Cavity Polyp	ERBB3 GIGYF2	3.49e-03	55	47	2	EFO_1000391
Disease	fat body mass	ZC3H18 CCDC171 AK7	5.01e-03	217	47	3	EFO_0005409
Disease	smoking behaviour measurement	ERBB3 HDGFL2 SDK1	5.34e-03	222	47	3	EFO_0005671
Disease	Alzheimer disease, gastroesophageal reflux disease	ERBB3 SDK1 CLASRP	5.75e-03	228	47	3	EFO_0003948, MONDO_0004975
Disease	ceramide measurement	KIF16B CCDC171 SDK1	6.25e-03	235	47	3	EFO_0010222

Protein segments in the cluster

Peptide	Gene	Start	Entry
DRIKVRVWDEDDDIK	UNC13A	736	Q9UPW8
IDWRDIVRDRDAEIV	ERBB3	161	P21860
RETARWIKFEEDVEE	SLC4A2	341	P04920
EEEERLEREHFWKII	CARNMT1	56	Q8N4J0
WKEECRRFEHDLEER	CCDC171	141	Q6TFL3
DERDEDWDAKKRELE	ANKRD66	151	B4E2M5
EDEWERTERERLQDL	DHX16	161	O60231
TDEEFWIREDEKREK	CECR2	546	Q9BXF3
WVEEEKRDLEGIRES	KIF16B	786	Q96L93
RRRAADEDWDSELED	RBM33	31	Q96EV2
WREERRREEKDRAWE	GPANK1	331	O95872
LEEDEDSAEWRRRRE	BSN	781	Q9UPA5
EAWKIRKELDEETER	PPL	891	O60437
EERMWEQDERLREKE	GOLGA6L2	396	Q8N9W4
DSDEVDRISEWKRRD	HDGFL2	306	Q7Z4V5
RKQEEEAAKWAREEE	GIGYF2	841	Q6Y7W6
KWDEFEDILEERRHV	GNPAT	31	O15228
RPSEEREWDREKERD	EIF3A	1196	Q14152
EVSSWRRADDRKDDR	EIF3A	1306	Q14152
DGDWESREELRLREL	CCDC102A	66	Q96A19
AREWEEARRAEVSEL	CCDC57	81	Q2TAC2
RLVEDEERRWTDENI	DYNC1H1	2836	Q14204
IEWAKRESEREEEQR	EPS15	856	P42566
LEEARRRKEDEVEEW	EZR	431	P15311
RKRRRWPSAEEEEEE	DHX37	151	Q8IY37
DRLEREFTIEELEEW	SDK1	1231	Q7Z5N4
KWDICEELRLRELEE	CCDC102B	66	Q68D86
WKRDREKRDDQDDVS	LARP1B	121	Q659C4
RWEREHQEREPDETE	DROSHA	1356	Q9NRR4
EEEERWRRKVICKEE	FNBP4	336	Q8N3X1
QIEEENREREWEREV	SIN3A	916	Q96ST3
ALEKEAEEWTRRAEE	WHAMM	276	Q8TF30
QWEREERERLEIARE	SAFB	636	Q15424
KRKHSDLEEEEERWE	SERTAD3	6	Q9UJW9
DIAEAEAEWEKRERE	CFAP210	351	Q0VFZ6
DESEARWRKERIERE	CLSPN	1166	Q9HAW4
ERERREKEREEWERQ	CLASRP	626	Q8N2M8
WREEEREKKAQDIET	SUPT6H	821	Q7KZ85
IDEELERDKRVTWIV	TMX2	146	Q9Y320
AVEWRERAVEKRERA	ZBED2	166	Q9BTP6
RKWEEDRDTVVEGLR	AGPAT3	146	Q9NRZ7
DTPEEIARWREERRK	NUFIP1	231	Q9UHK0
DIKSEDERWKEERDR	ZNF609	1151	O15014
ISLWKDEEVDTEDRR	ZDBF2	1221	Q9HCK1
KRERHEKEWEQESER	PHF3	1931	Q92576
EKEWEQESERHRRRD	PHF3	1936	Q92576
ERLVREELERWESDD	PKD2	906	Q13563
EIAEDELARDWTKRR	ZNF512B	696	Q96KM6
IREEEDWDDAFIKRK	ZCCHC18	216	P0CG32
EKLLERERERLHEEW	ZRSR2P1	66	Q15695
RVFQEEEEKEWRKRE	TCHH	236	Q07283
QEERRDWLKREEETE	TCHH	451	Q07283
DWLKREEETERHEQE	TCHH	456	Q07283
EEERRERWLKLEEEE	TCHH	481	Q07283
ELIRMVREEEDWDDA	ZCCHC12	211	Q6PEW1
VREEEDWDDAFIKRK	ZCCHC12	216	Q6PEW1
EEWERERAKRDEKDR	ZC3H18	451	Q86VM9
EEWNKRLEEVKREER	AK7	656	Q96M32