Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	presynaptic active zone	GABRB1 PPFIA1 GRM3 ADORA2A TENM3 OTOF SCN8A CACNA2D3	2.63e-05	141	176	8	GO:0048786
GeneOntologyCellularComponent	dendrite	GABRB1 SHANK1 KIF21B CASC3 RPL28 ZFYVE27 NTF3 PPFIA1 ROR2 CKAP5 GRM3 CHRM1 CHRM3 DICER1 PRR7 ADORA2A PPARGC1A SCN8A PLK3	1.18e-04	858	176	19	GO:0030425
GeneOntologyCellularComponent	dendritic tree	GABRB1 SHANK1 KIF21B CASC3 RPL28 ZFYVE27 NTF3 PPFIA1 ROR2 CKAP5 GRM3 CHRM1 CHRM3 DICER1 PRR7 ADORA2A PPARGC1A SCN8A PLK3	1.22e-04	860	176	19	GO:0097447
GeneOntologyCellularComponent	presynaptic membrane	GABRB1 IL31RA GRM3 CHRM1 CHRM3 ADORA2A TENM3 OTOF SCN8A CACNA2D3	1.25e-04	277	176	10	GO:0042734
GeneOntologyCellularComponent	heterochromatin	EME1 MBD1 DAXX MORC2 BAZ2A TOP2B	2.14e-04	101	176	6	GO:0000792
GeneOntologyCellularComponent	presynaptic active zone membrane	GABRB1 TENM3 OTOF SCN8A CACNA2D3	5.14e-04	78	176	5	GO:0048787
GeneOntologyCellularComponent	Sec61 translocon complex	SEC61A2 SEC61A1	6.93e-04	5	176	2	GO:0005784
Domain	SecY_su_dom	SEC61A2 SEC61A1	8.53e-05	2	173	2	IPR023201
Domain	SECY_1	SEC61A2 SEC61A1	8.53e-05	2	173	2	PS00755
Domain	SECY_2	SEC61A2 SEC61A1	8.53e-05	2	173	2	PS00756
Domain	-	SEC61A2 SEC61A1	8.53e-05	2	173	2	1.10.3370.10
Domain	Translocon_Sec61/SecY_plug_dom	SEC61A2 SEC61A1	8.53e-05	2	173	2	IPR019561
Domain	TF_homeodomain_male	PHTF2 PHTF1	8.53e-05	2	173	2	IPR021980
Domain	Phtf-FEM1B_bdg	PHTF2 PHTF1	8.53e-05	2	173	2	PF12129
Domain	SecY_CS	SEC61A2 SEC61A1	8.53e-05	2	173	2	IPR030659
Domain	Otx_TF	OTX1 OTX2	8.53e-05	2	173	2	IPR003025
Domain	Plug_translocon	SEC61A2 SEC61A1	8.53e-05	2	173	2	PF10559
Domain	SecY	SEC61A2 SEC61A1	8.53e-05	2	173	2	PF00344
Domain	SecY/SEC61-alpha	SEC61A2 SEC61A1	8.53e-05	2	173	2	IPR002208
Domain	Otx_TF_C	OTX1 OTX2	2.54e-04	3	173	2	IPR013851
Domain	TF_Otx	OTX1 OTX2	2.54e-04	3	173	2	PF03529
Domain	Tox-GHH_dom	TENM3 TENM1	5.06e-04	4	173	2	IPR028916
Domain	Tox-GHH	TENM3 TENM1	5.06e-04	4	173	2	PF15636
Domain	Ten_N	TENM3 TENM1	5.06e-04	4	173	2	IPR009471
Domain	Ten_N	TENM3 TENM1	5.06e-04	4	173	2	PF06484
Domain	TENEURIN_N	TENM3 TENM1	5.06e-04	4	173	2	PS51361
Domain	Musac_Ach_rcpt	CHRM1 CHRM3	8.38e-04	5	173	2	IPR000995
Domain	YD	TENM3 TENM1	8.38e-04	5	173	2	IPR006530
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CASC3 RBM15 SHROOM3 NUMBL DSP INPP5E ATG13 PPFIA1 MATR3 ROR2 MBD1 CKAP5 KDM3B TBC1D22B PFKFB2 MELK CIC C2CD3 CASKIN2 PLEKHG3 SVIL OSBPL10 IRS2	1.61e-10	861	181	23	36931259
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RPL28 EME1 RBM15 SRSF4 INO80C DSP MATR3 MBD1 CKAP5 NOL9 SIX4 PAF1 CREB1 CIC XAB2 NOP58 OTX1 MTA1 SF3B3 BAZ2A CDK13 MACO1 PRPF38A KAT14 TOP2B RPL18	4.01e-09	1294	181	26	30804502
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	MRPS31 CASC3 SHROOM3 BMP2K NUMBL PIEZO1 PPFIA1 MBD1 RBM26 CKAP5 DAXX NOL9 SIX4 MORC2 DICER1 CIC XAB2 CRACD MTA1 BAZ2A CDK13 PLEKHG3 MACO1 PRPF38A UTP3 VARS1 MOV10	1.88e-08	1497	181	27	31527615
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	MPP3 SPATA7 INPP5E ADAM9 WDR81 PCARE DICER1 OTX2 IRS2 TOP2B CRB2	4.46e-08	233	181	11	32290105
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	RBM15 SRSF4 DSP PPFIA1 MATR3 PCARE DAXX SF3B3 OTOF VARS1 TOP2B	4.65e-08	234	181	11	36243803
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	SRSF4 CKAP5 NOL9 PAF1 DICER1 XAB2 MTA1 BAZ2A PRPF38A TOP2B MOV10	9.48e-08	251	181	11	28077445
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF21B SHROOM3 USP28 INPP5E PIEZO1 MATR3 KDM3B MELK DICER1 ARHGEF10L FMNL3 SF3B3 CASKIN2 IPO13 EIF2AK4	1.36e-07	529	181	15	14621295
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MRPS31 RPL28 SHROOM3 NUMBL PIEZO1 PPFIA1 ROR2 NOL9 PAF1 DICER1 LGALS3BP SEC61A2 NOP58 SF3B3 ABCB10 BAZ2A CASKIN2 P3H1 MACO1 TUBGCP3 GHITM MTR SEC61A1 TOP2B RPL18	2.51e-07	1487	181	25	33957083
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FILIP1 EME1 RBM15 DSP MATR3 CKAP5 KDM3B DAXX MORC2 CIC MTA1 BAZ2A CDK13 SVIL IRS2 PRPF38A TOP2B	7.07e-07	774	181	17	15302935
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	COG2 COG7 SPTLC2 MATR3 RBM26 CKAP5 NOL9 PAF1 XAB2 MTA1 ABCB10 MOCS3 TUBGCP3 VARS1	1.59e-06	560	181	14	35241646
Pubmed	UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.	CASC3 RPL28 DAXX NOL9 CDK13 UTP3 MOV10 RPL18	1.65e-06	155	181	8	34921745
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	MRPS31 RAD51 KIF21B COG2 RBM15 SPTLC2 BICRA MATR3 RBM26 MORC2 CREB1 DICER1 XAB2 DPH6 CRACD NOP58 OTX2 SF3B3 CDK13 EIF2AK4 KAT14 RPL18	1.77e-06	1327	181	22	32694731
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	MRPS31 RBM15 SHROOM3 DAXX PFKFB2 LGALS3BP SPTBN5 NOP58 ATAD3C UTP3 PIPSL POLQ SEC61A1	2.27e-06	496	181	13	31343991
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	RPL28 RBM15 BMP2K DSP TPRN MATR3 DAXX ADORA2A NOP58 SF3B3 CDK13 PLEKHG3 SVIL UTP3 SEC61A1 VARS1 MOV10 RPL18	2.63e-06	949	181	18	36574265
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	EME1 RBM15 RBM26 DAXX PAF1 MORC2 NOP58 POLQ KAT14	2.72e-06	222	181	9	37071664
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	DSP USP28 MBD1 RBM26 CKAP5 NOL9 SIX4 MORC2 CREB1 CIC LGALS3BP CRACD DES MTA1 VARS1 TOP2B MOV10	2.80e-06	857	181	17	25609649
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RPL28 RBM15 DSP USP28 TPRN DAXX PAF1 CREB1 CIC SF3B3 MACO1 MTR CFAP44 KAT14	2.80e-06	588	181	14	38580884
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	CASC3 RBM15 INO80C DSP PPFIA1 MATR3 RBM26 NOL9 MORC2 DICER1 XAB2 LGALS3BP APOBEC3F NOP58 CDK13 SVIL TUBGCP3 EIF2AK4 PRPF38A PIPSL VARS1 MOV10	2.99e-06	1371	181	22	36244648
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	RPL28 SRSF4 DICER1 XAB2 NOP58 SF3B3 TUBGCP3 PRPF38A SEC61A1 RPL18	4.33e-06	300	181	10	28561026
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	MRPS31 RPL28 RBM15 DSP USP28 MATR3 RBM26 DAXX NOL9 PAF1 XAB2 NOP58 SF3B3 UTP3 SEC61A1 VARS1 TOP2B RPL18	4.65e-06	989	181	18	36424410
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	MRPS31 CASC3 RPL28 SRSF4 MATR3 XAB2 DES NOP58 SF3B3 DDA1 PRPF38A VARS1 TOP2B MOV10 RPL18	5.59e-06	714	181	15	28302793
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RAD51 MPP3 SEMA6B TPRA1 SHROOM3 BICRA INPP5E PIEZO1 DOCK9 MYOM3 KDM3B TEP1 CIC ARHGEF10L C2CD3 CDK13 SCN8A IRS2 PLK3	5.63e-06	1105	181	19	35748872
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	MRPS31 CASC3 RPL28 RBM15 SRSF4 BMP2K MATR3 KDM3B NOL9 PAF1 XAB2 NOP58 SF3B3 ABCB10 BAZ2A PRPF38A SEC61A1 VARS1 TOP2B MOV10 RPL18	5.69e-06	1318	181	21	30463901
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MRPS31 RPL28 EME1 DSP PPFIA1 MATR3 DNAH2 SEC61A2 DES C2CD3 SF3B3 ATAD3C CDK13 TENM1 EIF2AK4 ABCC2 POLQ SEC61A1 VARS1 TOP2B PHTF1 RPL18	6.66e-06	1442	181	22	35575683
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	RBM15 CKAP5 NOL9 PAF1 XAB2 BAZ2A SVIL PRPF38A UTP3 TOP2B	1.05e-05	332	181	10	25693804
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RBM15 SRSF4 DSP BICRA MATR3 RBM26 PAF1 CREB1 CIC XAB2 NOP58 MTA1 SF3B3 BAZ2A SIMC1 UTP3 TOP2B	1.14e-05	954	181	17	36373674
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 KIF21B CASC3 SHROOM3 NUMBL USP28 ADAM9 PPFIA1 MATR3 APC2 CKAP5 WDR81 MSANTD2 NOL9 PAF1 GRM3 SVIL	1.28e-05	963	181	17	28671696
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	DSP MATR3 MBD1 SIX4 PAF1 MORC2 CREB1 CIC NOP58 OTX1 MTA1 SF3B3 BAZ2A	1.29e-05	583	181	13	29844126
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	RBM15 DSP BICRA MATR3 ROR2 CKAP5 KDM3B SF3B3 TOP2B	1.40e-05	272	181	9	31010829
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	MRPS31 RPL28 RBM15 SRSF4 DSP MATR3 MELK XAB2 NOP58 SF3B3 CDK13 SEC61A1 MOV10 RPL18	1.40e-05	678	181	14	30209976
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MPP3 RPL28 SRSF4 SPTLC2 PPFIA1 MATR3 RBM26 CKAP5 SIX4 DICER1 THOP1 MACO1 GHITM IRS2 PIPSL SEC61A1 VARS1	1.48e-05	974	181	17	28675297
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	MRPS31 CASC3 RPL28 RBM15 SRSF4 MATR3 RBM26 XAB2 APOBEC3F NOP58 PRPF38A TOP2B MOV10 RPL18	2.44e-05	713	181	14	29802200
Pubmed	Elevated PAF1-RAD52 axis confers chemoresistance to human cancers.	RAD52 PAF1	2.69e-05	2	181	2	36709426
Pubmed	Cell type-specific dependence of muscarinic signalling in mouse hippocampal stratum oriens interneurones.	CHRM1 CHRM3	2.69e-05	2	181	2	16322052
Pubmed	Ventilatory pattern and chemosensitivity in M1 and M3 muscarinic receptor knockout mice.	CHRM1 CHRM3	2.69e-05	2	181	2	15122990
Pubmed	The putative nuclear localization signal of the human RAD52 protein is a potential sumoylation site.	RAD51 RAD52	2.69e-05	2	181	2	20190268
Pubmed	Daxx interacts with and modulates the activity of CREB.	DAXX CREB1	2.69e-05	2	181	2	22185778
Pubmed	Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.	OTX1 OTX2	2.69e-05	2	181	2	10068635
Pubmed	DAXX ameliorates metabolic dysfunction in mice with diet-induced obesity by activating the AMP-activated protein kinase-related kinase MPK38/MELK.	DAXX MELK	2.69e-05	2	181	2	34365141
Pubmed	Specific interactions between the human RAD51 and RAD52 proteins.	RAD51 RAD52	2.69e-05	2	181	2	8550550
Pubmed	Roles of C-Terminal Region of Yeast and Human Rad52 in Rad51-Nucleoprotein Filament Formation and ssDNA Annealing.	RAD51 RAD52	2.69e-05	2	181	2	27362509
Pubmed	Dicer knockdown inhibits endothelial cell tumor growth via microRNA 21a-3p targeting of Nox-4.	NOX4 DICER1	2.69e-05	2	181	2	24497637
Pubmed	From fly head to mammalian forebrain: the story of otd and Otx.	OTX1 OTX2	2.69e-05	2	181	2	7974744
Pubmed	Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors.	CHRM1 CHRM3	2.69e-05	2	181	2	24821386
Pubmed	Cholinergic modulation amplifies the intrinsic oscillatory properties of CA1 hippocampal cholecystokinin-positive interneurons.	CHRM1 CHRM3	2.69e-05	2	181	2	21115639
Pubmed	Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants.	OTX1 OTX2	2.69e-05	2	181	2	16611693
Pubmed	Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells.	CREB1 PPARGC1A	2.69e-05	2	181	2	25099937
Pubmed	Visualisation of human rad52 protein and its complexes with hRad51 and DNA.	RAD51 RAD52	2.69e-05	2	181	2	9837724
Pubmed	Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52.	RAD51 RAD52	2.69e-05	2	181	2	10438626
Pubmed	Otx genes in corticogenesis and brain development.	OTX1 OTX2	2.69e-05	2	181	2	10498271
Pubmed	MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change.	DICER1 MOV10	2.69e-05	2	181	2	30621721
Pubmed	Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.	RAD52 POLQ	2.69e-05	2	181	2	31381562
Pubmed	Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus.	CHRM1 CHRM3	2.69e-05	2	181	2	16319319
Pubmed	Epithelial muscarinic M1 receptors contribute to carbachol-induced ion secretion in mouse colon.	CHRM1 CHRM3	2.69e-05	2	181	2	16405887
Pubmed	Evidence that anti-muscarinic antibodies in Sjögren's syndrome recognise both M3R and M1R.	CHRM1 CHRM3	2.69e-05	2	181	2	18249005
Pubmed	Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1.	MBD1 OASL	2.69e-05	2	181	2	14728690
Pubmed	M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells.	CHRM1 CHRM3	2.69e-05	2	181	2	23242454
Pubmed	Genetic determinants of blood pressure responses to caffeine drinking.	ADORA2A ADRA2B	2.69e-05	2	181	2	22170367
Pubmed	Otx2 expression in anterior neuroectoderm and forebrain/midbrain is directed by more than six enhancers.	OTX1 OTX2	2.69e-05	2	181	2	24457099
Pubmed	Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines.	CHRM1 CHRM3	2.69e-05	2	181	2	27173511
Pubmed	Human Rad51 amino acid residues required for Rad52 binding.	RAD51 RAD52	2.69e-05	2	181	2	10448035
Pubmed	Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus.	CHRM1 CHRM3	2.69e-05	2	181	2	12859343
Pubmed	Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes.	MPL IRS2	2.69e-05	2	181	2	11054408
Pubmed	Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line.	RAD51 RAD52	2.69e-05	2	181	2	11809887
Pubmed	Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells.	RAD51 RAD52	2.69e-05	2	181	2	11691922
Pubmed	Developmental rescue of Drosophila cephalic defects by the human Otx genes.	OTX1 OTX2	2.69e-05	2	181	2	9520436
Pubmed	Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families.	OTOF MYO15A	2.69e-05	2	181	2	37189200
Pubmed	Rad51 and Rad52 are involved in homologous recombination of replicating herpes simplex virus DNA.	RAD51 RAD52	2.69e-05	2	181	2	25365323
Pubmed	Otx genes and the genetic control of brain morphogenesis.	OTX1 OTX2	2.69e-05	2	181	2	10049527
Pubmed	DNA mediated disassembly of hRad51 and hRad52 proteins and recruitment of hRad51 to ssDNA by hRad52.	RAD51 RAD52	2.69e-05	2	181	2	16367760
Pubmed	Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells.	CHRM1 CHRM3	2.69e-05	2	181	2	19927300
Pubmed	Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.	SEC61A2 SEC61A1	2.69e-05	2	181	2	18480044
Pubmed	Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation.	OTX1 OTX2	2.69e-05	2	181	2	16738237
Pubmed	M1 receptor-mediated nitric oxide-dependent relaxation unmasked in stomach fundus from M3 receptor knockout mice.	CHRM1 CHRM3	2.69e-05	2	181	2	12538821
Pubmed	M1 muscarinic receptor signaling in mouse hippocampus and cortex.	CHRM1 CHRM3	2.69e-05	2	181	2	12106668
Pubmed	The function of RAD52 N-terminal domain is essential for viability of BRCA-deficient cells.	RAD51 RAD52	2.69e-05	2	181	2	33275133
Pubmed	Function and evolution of Otx proteins.	OTX1 OTX2	2.69e-05	2	181	2	10375352
Pubmed	Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line.	CHRM1 CHRM3	2.69e-05	2	181	2	18385290
Pubmed	Otx1 and Otx2 in the development and evolution of the mammalian brain.	OTX1 OTX2	2.69e-05	2	181	2	9843484
Pubmed	Gene and domain duplication in the chordate Otx gene family: insights from amphioxus Otx.	OTX1 OTX2	2.69e-05	2	181	2	9580990
Pubmed	Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum.	OTX1 OTX2	2.69e-05	2	181	2	7931541
Pubmed	Structural evolution of Otx genes in craniates.	OTX1 OTX2	2.69e-05	2	181	2	11504847
Pubmed	cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.	CREB1 IRS2	2.69e-05	2	181	2	12842910
Pubmed	Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice.	CHRM1 CHRM3	2.69e-05	2	181	2	15266016
Pubmed	Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling.	CREB1 PPARGC1A	2.69e-05	2	181	2	39043630
Pubmed	Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain.	OTX1 OTX2	2.69e-05	2	181	2	20354145
Pubmed	Evolution and homology of the nervous system: cross-phylum rescues of otd/Otx genes.	OTX1 OTX2	2.69e-05	2	181	2	9635399
Pubmed	Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling.	CHRM1 CHRM3	2.69e-05	2	181	2	23776234
Pubmed	Long-Term-But Not Short-Term-Plasticity at the Mossy Fiber-CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice.	CHRM1 CHRM3	2.69e-05	2	181	2	37508553
Pubmed	CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.	CREB1 PPARGC1A	2.69e-05	2	181	2	11557984
Pubmed	Effect of DNA sequence and nucleotide cofactors on hRad51 binding to ssDNA: role of hRad52 in recruitment.	RAD51 RAD52	2.69e-05	2	181	2	16018971
Pubmed	Human RAD52 stimulates the RAD51-mediated homology search.	RAD51 RAD52	2.69e-05	2	181	2	38081641
Pubmed	Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.	CHRM1 CHRM3	2.69e-05	2	181	2	30157420
Pubmed	Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals.	PHTF2 PHTF1	2.69e-05	2	181	2	10729229
Pubmed	OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas.	OTX1 OTX2	2.69e-05	2	181	2	28348423
Pubmed	Genetic and molecular roles of Otx homeodomain proteins in head development.	OTX1 OTX2	2.69e-05	2	181	2	10767524
Pubmed	OTX1 and OTX2 Genes in Medulloblastoma.	OTX1 OTX2	2.69e-05	2	181	2	30797919
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	BMP2K PPFIA1 CKAP5 DAXX PAF1 MORC2 DICER1 XAB2 NOP58 MTA1 SF3B3 VARS1 TOP2B MOV10	2.88e-05	724	181	14	36232890
Pubmed	The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.	CASC3 RPL28 SRSF4 MATR3 XAB2 SF3B3 RPL18	3.12e-05	169	181	7	23084401
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	RPL28 RBM15 SHROOM3 SRSF4 DSP MATR3 XAB2 LGALS3BP CRACD NOP58 SF3B3 PRPF38A MOV10 RPL18	3.20e-05	731	181	14	29298432
Interaction	YWHAG interactions	KIF21B CASC3 RBM15 SHROOM3 NUMBL DSP INPP5E ATG13 PPFIA1 DOCK9 MATR3 ROR2 MBD1 CKAP5 KDM3B TBC1D22B PFKFB2 MELK CIC CRACD C2CD3 SF3B3 CASKIN2 PLEKHG3 SVIL SIMC1 OSBPL10 IRS2	4.35e-06	1248	177	28	int:YWHAG
Interaction	SLX4 interactions	EME1 RBM15 DSP MATR3 RBM26 KDM3B DAXX PAF1 MORC2 XAB2 NOP58 SF3B3 POLQ KAT14 PLK3 VARS1 RPL18	1.24e-05	572	177	17	int:SLX4
Interaction	PYHIN1 interactions	SRSF4 MBD1 CKAP5 DAXX NOL9 PAF1 DICER1 XAB2 MTA1 BAZ2A PRPF38A TOP2B MOV10	1.76e-05	358	177	13	int:PYHIN1
GeneFamily	Cholinergic receptors muscarinic	CHRM1 CHRM3	4.38e-04	5	121	2	180
GeneFamily	Fibronectin type III domain containing\|I-set domain containing\|Myosin binding proteins	MYOM3 MYBPHL	1.21e-03	8	121	2	658
GeneFamily	Components of oligomeric golgi complex	COG2 COG7	1.21e-03	8	121	2	493
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	GARNL3 NTF3 ARHGEF10L DES SVIL PDZRN3 CACNA2D3 PDZRN4	5.64e-07	173	181	8	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	SHROOM3 GARNL3 NTF3 CHRM3 MICAL2 SVIL PDZRN3 PDZRN4	1.06e-06	188	181	8	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	MPP3 FILIP1 MYOM3 PPARGC1A SVIL PLCXD3 PDZRN3 CACNA2D3	1.14e-06	190	181	8	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 NTF3 ROR2 TENM3 MICAL2 PODN PLCXD3 PDZRN4	1.24e-06	192	181	8	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	GABRB1 MPP3 FILIP1 MYOM3 PPARGC1A SVIL PLCXD3 PDZRN3	1.39e-06	195	181	8	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	MPP3 FILIP1 MYOM3 DES PPARGC1A SVIL PLCXD3 PDZRN3	1.39e-06	195	181	8	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 NTF3 ROR2 FMNL3 CRACD TENM3 MICAL2 PDZRN3	1.44e-06	196	181	8	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 NTF3 ROR2 FMNL3 CRACD TENM3 MICAL2 PDZRN3	1.44e-06	196	181	8	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	PIEZO1 GRM3 MAMDC4 ADCY1 PPARGC1A SPON2 CYB561D1 MYO15A	1.68e-06	200	181	8	a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCell	Frontal_cortex\|World / BrainAtlas - Mouse McCarroll V32	GARNL3 CHRM1 CHRM3 ADCY1 MICAL2 PODN NPY	4.96e-06	164	181	7	e09291711abf8680e78170328313719092b0142f
ToppCell	NS-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	WSCD1 DSP AMACR PCDHB3 CHRM3 PPARGC1A PDZRN3	8.80e-06	179	181	7	65a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FILIP1 PRTG NTF3 GPR149 SVIL TENM1 PLCXD3	9.46e-06	181	181	7	af92b8b7f455210dab502ef6964f3a0162180759
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP28 KDM3B TRIM39 SLC7A7 TEP1 FMNL3 SCMH1	9.46e-06	181	181	7	f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 SRSF4 NOX4 SCMH1 MICAL2 SVIL OSBPL10	1.05e-05	184	181	7	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	MPP3 FILIP1 MYOM3 DES SVIL PLCXD3 PDZRN3	1.05e-05	184	181	7	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	GABRB1 MPP3 FILIP1 MYOM3 DES PLCXD3 PDZRN3	1.05e-05	184	181	7	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MPP3 FILIP1 MYOM3 DES SVIL PLCXD3 PDZRN3	1.09e-05	185	181	7	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	Control-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	ACO1 CXCL16 SLC7A7 CHRM3 LGALS3BP SVIL OASL	1.09e-05	185	181	7	85cb81759589a26d83676cffbf2bc37399683c10
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD PPARGC1A MYBPHL CACNA2D3 PDZRN4	1.13e-05	186	181	7	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD PPARGC1A MYBPHL CACNA2D3 PDZRN4	1.13e-05	186	181	7	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD PPARGC1A MYBPHL CACNA2D3 PDZRN4	1.25e-05	189	181	7	e758b264c0a47127e33e66c395cf5a3224c7305b
ToppCell	facs-Heart-RA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD PPARGC1A MYBPHL CACNA2D3 PDZRN4	1.25e-05	189	181	7	b98f60875b1a12b2ec9dc91889298ae57f98602f
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	IL31RA MYOM3 NOX4 PODN PDZRN3 MOV10	1.29e-05	126	181	6	83f3540683b3b175b10af059ab8898c46eaccc13
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	IL31RA MYOM3 NOX4 PODN PDZRN3 MOV10	1.29e-05	126	181	6	6d5075d659dac7b96e6857f8485a7d2c4105d685
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	IL31RA MYOM3 NOX4 PODN PDZRN3 MOV10	1.29e-05	126	181	6	fd0001a0f3a0a4421f96fd21813c21cf6f01d40e
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	IL31RA MYOM3 NOX4 PODN PDZRN3 MOV10	1.29e-05	126	181	6	f20424f9baf3c4059cd6b701761e7595400fc47c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 GARNL3 DES MICAL2 SVIL PODN PDZRN4	1.30e-05	190	181	7	2e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 ROR2 DES MICAL2 SVIL PDZRN3 PDZRN4	1.30e-05	190	181	7	562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 GARNL3 DES MICAL2 SVIL PODN PDZRN4	1.30e-05	190	181	7	0028f886c789ba238c031eae5d96acaed4af8c25
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 NTF3 ROR2 CRACD TENM3 MICAL2 PDZRN4	1.30e-05	190	181	7	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 ROR2 DES MICAL2 SVIL PDZRN3 PDZRN4	1.30e-05	190	181	7	f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	MPP3 FILIP1 MYOM3 PPARGC1A SVIL PLCXD3 PDZRN3	1.34e-05	191	181	7	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	MPP3 FILIP1 USP28 MYOM3 DES PPARGC1A SVIL	1.34e-05	191	181	7	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD DES PPARGC1A MYBPHL PDZRN4	1.34e-05	191	181	7	c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 NTF3 ROR2 CRACD TENM3 MICAL2 PLCXD3	1.34e-05	191	181	7	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD DES PPARGC1A MYBPHL PDZRN4	1.34e-05	191	181	7	715f5b449b8e075959c05a5b38389df319663164
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 NTF3 ROR2 CRACD TENM3 MICAL2 PLCXD3	1.34e-05	191	181	7	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 NTF3 ROR2 TENM3 PODN PLCXD3 PDZRN4	1.39e-05	192	181	7	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD DES PPARGC1A MYBPHL PDZRN4	1.39e-05	192	181	7	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD DES PPARGC1A MYBPHL PDZRN4	1.39e-05	192	181	7	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	MPP3 FILIP1 MYOM3 PPARGC1A SVIL PLCXD3 PDZRN3	1.43e-05	193	181	7	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	MPP3 FILIP1 USP28 MYOM3 PPARGC1A SVIL PDZRN3	1.48e-05	194	181	7	c3535f7cc0076653c72db582047cff053c322397
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD DES PPARGC1A PODN MYBPHL	1.59e-05	196	181	7	a582130862bee76c0385156a333bfdfc75cf218b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSP ADCY1 CRACD DES PPARGC1A PODN MYBPHL	1.59e-05	196	181	7	fba52a4b82086dbae9a55038bf44c4539be926f5
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FILIP1 DES P3H1 SPON2 PODN PDZRN3 PDZRN4	1.64e-05	197	181	7	7d97c2d51a543c02d679e9257b22d0581e73a11d
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ROR2 DES TENM3 GALNT9 PODN CRB2 PDZRN4	1.64e-05	197	181	7	88a86286b9c3ea3b076d7464faec42d0392ee7f8
ToppCell	Parenchymal-10x5prime-Stromal-Mesofibroblastic-Mesothelia\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ROR2 DES TENM3 GALNT9 PODN CRB2 PDZRN4	1.64e-05	197	181	7	2773d2eb5f232a7e49da116efffcb6bf5eb90810
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FILIP1 DES P3H1 SPON2 PODN PDZRN3 PDZRN4	1.64e-05	197	181	7	671d6b5effbac2dd71d18f48d23c523738db1828
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TMEM30B IL31RA CXCL16 PPP1R14D SPON2 PODN	1.68e-05	132	181	6	893b7ec2a2d8a140cc98575d1beca1189f053e9a
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Mesothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	SHANK1 ROR2 DES TENM3 GALNT9 PODN CRB2	1.75e-05	199	181	7	ca970114b5aef4518ce580897a62ac88688b2671
ToppCell	Biopsy_IPF-Mesenchymal-Mesothelial_cells\|Biopsy_IPF / Sample group, Lineage and Cell type	ROR2 DES TENM3 GALNT9 PODN CRB2 PDZRN4	1.81e-05	200	181	7	553386523fd8f8f36617a0d81032224b7ddce442
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	KIF21B DOCK9 ADCY1 CRACD TENM1 PDZRN3 PDZRN4	1.81e-05	200	181	7	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	SEMA6B WSCD1 TPRA1 LGALS3BP PODN MOV10 CRB2	1.81e-05	200	181	7	4db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	SEMA6B WSCD1 TPRA1 LGALS3BP PODN MOV10 CRB2	1.81e-05	200	181	7	d46a19274c2836ce7494790ce513764dedcadc79
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TMEM30B NUMBL USP28 MORC2 MICAL2 SIMC1 PDZRN4	1.81e-05	200	181	7	be46efc899d06c55ee297bee3126f69bcdb2048b
ToppCell	LPS-IL1RA-Endothelial-Mes-Like-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WSCD1 PCDHB3 NOX4 MAMDC4 AK8 CFAP44	2.85e-05	145	181	6	90ca38c02325c5c637c32efdef634b54cc3cd105
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPATA7 NUMBL TSEN54 PLEKHG3 SIMC1 PLK3	3.86e-05	153	181	6	489228ab81c3ae339a53a9da6c2a1c1b6ac3f84b
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	IL31RA DNAH2 NOX4 SPTBN5 SPON2	3.89e-05	93	181	5	af489f0dd76c3c1a84d164283149f550a7ece91c
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	IL31RA DNAH2 NOX4 SPTBN5 SPON2	3.89e-05	93	181	5	c1d0afcfa37c2dcbb12189b4ce56ae7c4bb7ba30
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	IL31RA DNAH2 NOX4 SPTBN5 SPON2	3.89e-05	93	181	5	0ea74c2820372d60d3804bf2c8bb0d03733dff98
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 CRACD DES MICAL2 PODN PDZRN4	4.30e-05	156	181	6	d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 CRACD DES MICAL2 PODN PDZRN4	4.30e-05	156	181	6	363f1b661048d25895e2b8681c82894c957b29c0
ToppCell	Fetal_29-31_weeks-Immune-mast_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PHTF2 IL18RAP SIRT4 ATAD3C SCART1 CRB2	4.62e-05	158	181	6	0c27c475289c70b17b6a66fc71f628511c5f0ae1
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DES OTX1 KCNG4 PLCXD3 NPY CRB2	5.88e-05	165	181	6	4cdd80580d5638fd649280ba3893251c2f898f3f
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DES OTX1 KCNG4 PLCXD3 NPY CRB2	5.88e-05	165	181	6	c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCell	droplet-Marrow-BM-1m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRPS31 DAXX TSEN54 MAMDC4 CIC MTR	6.49e-05	168	181	6	2e88d9cb7c80a4656fab290db8b45a5a0599d769
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DES SPON2 SVIL MYBPHL PDZRN3 CACNA2D3	6.71e-05	169	181	6	88aa2246ede582c2e11de63228d76f520889ecb3
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DES SPON2 SVIL MYBPHL PDZRN3 CACNA2D3	6.71e-05	169	181	6	a6a5b00912b653fad2ca7f096deaf35c9ef85e5b
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DES SPON2 SVIL MYBPHL PDZRN3 CACNA2D3	6.71e-05	169	181	6	42a9b8c77d2a4d68b01e4db38f8a1af53c9c814f
ToppCell	BL-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	GARNL3 AMACR CHRM3 PPARGC1A TENM3 CACNA2D3	6.93e-05	170	181	6	b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell	facs\|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL RBM15 BICRA RBM26 LGALS3BP SEC61A1	7.16e-05	171	181	6	c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMEM30B NTF3 XAB2 CRACD BAZ2A PLCXD3	7.16e-05	171	181	6	2a34685f7d83d1cf9a88d304173cbca868c5f9fd
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL PRTG GARNL3 OTOF GALNT9 PLCXD3	7.39e-05	172	181	6	3f784aed340b50ddbec3f7dc0a5279180d38a2bb
ToppCell	390C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RAD52 TMEM30B COG2 SLC7A7 DPH6 GALNT8	7.39e-05	172	181	6	84d16cd7f618c94888920680bdc9e7130d73fd75
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INTS6L IL31RA TRIM39 ARHGEF10L BAZ2A SVIL	7.64e-05	173	181	6	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INTS6L IL31RA TRIM39 ARHGEF10L BAZ2A SVIL	7.64e-05	173	181	6	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Ifitm1_(Ifitm1)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TMEM30B IL31RA PPP1R14D SPON2 PODN	7.95e-05	108	181	5	db82e0273ce10627462ff0402f4c1d4c9cb3875b
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Ifitm1_(Ifitm1)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TMEM30B IL31RA PPP1R14D SPON2 PODN	7.95e-05	108	181	5	2a00a9d3c9ef0c9c743939ee6e79ccbd401eccf7
ToppCell	Substantia_nigra-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TMEM30B IL31RA PPP1R14D SPON2 PODN	7.95e-05	108	181	5	0c8bac6c520a3600765327c44705675927bc2f60
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FILIP1 SHROOM3 OTOF TENM1 NPY PDZRN4	8.13e-05	175	181	6	90e29945aa861082c94bb4f331161adc3a6ef899
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM30B DSP TENM3 PODN NPY CACNA2D3	8.66e-05	177	181	6	8f0873d348f37c823294b698043319b6608b678a
ToppCell	Control-Epithelial_alveolar-AT_1-AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FILIP1 SHROOM3 DSP CXCL16 LGALS3BP CACNA2D3	8.93e-05	178	181	6	1817bc520f3d23da8c0fa09bba50ae703a820cb1
ToppCell	Control-Fibroblasts-Airway_smooth_muscle\|Control / group, cell type (main and fine annotations)	GARNL3 NTF3 DES SVIL PDZRN3 PDZRN4	9.50e-05	180	181	6	d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell	-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ROR2 DES TENM3 GALNT9 PODN CRB2	9.79e-05	181	181	6	ef579e958f334da0f9415aa7e3d5c02c807954a6
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MPP3 FILIP1 MYOM3 DES PLCXD3 PDZRN3	9.79e-05	181	181	6	719eb532453ab7cd7893726885bc75d74a10b21e
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	RAD51 CHST10 ZNF862 MELK DES POLQ	1.01e-04	182	181	6	b1e66ccd5f33b4801f1cafddf97f5fc0c6dba8d1
ToppCell	cellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PATL2 USP28 DAXX IL18RAP NOP58 SPON2	1.01e-04	182	181	6	8ccffcbae28c374fd4161fb0d4cf2c49fae557f6
ToppCell	COVID-19-Heart-CM_4\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MPP3 FILIP1 MYOM3 PFKFB2 DES PLCXD3	1.04e-04	183	181	6	2902b6e8aa9a6f62bc1a792c971ab7f651a8e676
ToppCell	facs-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM30B ACO1 ADAM9 NOX4 IRS2 ABCC2	1.04e-04	183	181	6	d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM30B SHROOM3 DSP CHRM1 PPARGC1A GALNT8	1.07e-04	184	181	6	886d2d9bf2fe31207f17e3edc309ef44029924e1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FILIP1 NTF3 ROR2 CRACD TENM3 PLCXD3	1.07e-04	184	181	6	c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-goblet\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM30B SHROOM3 DSP CHRM1 PPARGC1A GALNT8	1.07e-04	184	181	6	936b39377eebea3961d702532779f6cd27953be7
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	ACO1 CXCL16 CHRM3 LGALS3BP SVIL OASL	1.07e-04	184	181	6	7fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FILIP1 NTF3 GPR149 SVIL TENM1 PLCXD3	1.07e-04	184	181	6	7d41784eac0935e77d6bc701f20c693adf998730
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MPP3 FILIP1 SHROOM3 MICAL2 OSBPL10 CACNA2D3	1.07e-04	184	181	6	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	Control-Epithelial-Mesothelial\|Epithelial / Disease state, Lineage and Cell class	ROR2 DES GALNT9 PODN CRB2 PDZRN4	1.10e-04	185	181	6	0af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	MPP3 FILIP1 MYOM3 DES PLCXD3 PDZRN3	1.10e-04	185	181	6	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FILIP1 PRTG DES SPON2 PDZRN3 CACNA2D3	1.14e-04	186	181	6	b58db5abdd3e9f0214b198c3cbd09b0b3c321eab
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 PHF7 TMEM101 SIRT4 APOBEC3F SIMC1	1.14e-04	186	181	6	77bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FILIP1 PRTG DES SPON2 PDZRN3 CACNA2D3	1.14e-04	186	181	6	cd6502bbf9dce318fdbb4965d49df8951e5f795c
Drug	Ascorbic acid [50-81-7]; Up 200; 22.4uM; MCF7; HT_HG-U133A	MPL KIF21B WSCD1 CHST10 SPTLC2 DOCK9 PPP1R14D GRM3 CHRM3 TENM1	3.12e-06	196	176	10	3225_UP
Drug	Nocodazole [31430-18-9]; Up 200; 13.2uM; MCF7; HT_HG-U133A	MPP3 WSCD1 RPL28 ZNF862 CASKIN2 PLEKHG3 IRS2 PLK3 UTF1	1.50e-05	186	176	9	6793_UP
Drug	3-isoreserpine	PAF1 CHRM1 ADCY1 ADORA2A ADRA2B SF3B3 ABCB10 ABCC2 NPY	1.78e-05	190	176	9	CID000005052
Drug	forskolin; Up 200; 50uM; HL60; HG-U133A	KIF21B ATG13 RBM26 PHF7 PPP1R14D ADORA2A MICAL2 IRS2 RPL18	2.01e-05	193	176	9	783_UP
Drug	(+) -Levobunolol hydrochloride [47141-41-3]; Down 200; 12.2uM; PC3; HT_HG-U133A	RAD52 PHTF2 PHF7 TEP1 BAZ2A MOCS3 CASKIN2 OASL PLK3	2.19e-05	195	176	9	6635_DN
Drug	D-cycloserine [68-41-7]; Up 200; 39.2uM; MCF7; HT_HG-U133A	BMP2K ZNF862 MBD1 PPP1R14D CIC ADORA2A OASL IRS2 PLK3	2.28e-05	196	176	9	6782_UP
Drug	Alcuronium chloride [15180-03-7]; Down 200; 5.4uM; MCF7; HT_HG-U133A	WSCD1 SPTLC2 ZNF862 DICER1 CIC OASL IRS2 ABCC2 PLK3	2.28e-05	196	176	9	4409_DN
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; MCF7; HT_HG-U133A	RAD52 WSCD1 BICRA ZNF862 CIC ATP10D MTA1 CDK13 ABCC2	2.37e-05	197	176	9	2327_DN
Drug	Isosorbide dinitrate [87-33-2]; Up 200; 17uM; MCF7; HT_HG-U133A	MPP3 DOCK9 APC2 RBM26 PHTF2 TBC1D22B PFKFB2 SIRT4 BAZ2A	2.37e-05	197	176	9	4742_UP
Drug	Iohexol [66108-95-0]; Down 200; 4.8uM; MCF7; HT_HG-U133A	RAD51 RAD52 WSCD1 CHST10 BMP2K MBD1 ATP10D OASL ABCC2	2.47e-05	198	176	9	5704_DN
Drug	Isoxicam [34552-84-6]; Down 200; 12uM; HL60; HT_HG-U133A	BMP2K ATG13 PIEZO1 CREB1 XAB2 PRR7 MTA1 SVIL PLK3	2.47e-05	198	176	9	1862_DN
Disease	Huntington's disease (biomarker_via_orthology)	CREB1 PPARGC1A NPY	1.07e-04	16	174	3	DOID:12858 (biomarker_via_orthology)
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	TPRN ADCY1 OTOF MYO15A	2.35e-04	51	174	4	cv:CN043650
Disease	Seizures	APC2 KDM3B CHRM1 ADORA2A MTR ABCC2 NPY	3.26e-04	218	174	7	C0036572
Disease	Withdrawal Symptoms	CREB1 ADCY1 ADORA2A NPY	3.87e-04	58	174	4	C0087169
Disease	Drug Withdrawal Symptoms	CREB1 ADCY1 ADORA2A NPY	3.87e-04	58	174	4	C0086189
Disease	Substance Withdrawal Syndrome	CREB1 ADCY1 ADORA2A NPY	3.87e-04	58	174	4	C0038587
Disease	Hyperkinesia	ADCY1 ADORA2A NPY	8.81e-04	32	174	3	C3887506
Disease	Hyperkinesia, Generalized	ADCY1 ADORA2A NPY	8.81e-04	32	174	3	C0751217
Disease	Myofibrillar Myopathy	MATR3 DES	9.46e-04	8	174	2	C2678065
Disease	Nonsyndromic genetic hearing loss	TPRN ADCY1 OTOF MYO15A	1.08e-03	76	174	4	cv:C5680182
Disease	Tremor, Neonatal	ADORA2A SCN8A	1.21e-03	9	174	2	C0235843
Disease	Tremor, Perioral	ADORA2A SCN8A	1.21e-03	9	174	2	C0235078
Disease	Nerve Tremors	ADORA2A SCN8A	1.21e-03	9	174	2	C0235083
Disease	Tremor, Limb	ADORA2A SCN8A	1.21e-03	9	174	2	C0235081
Disease	Tremor, Muscle	ADORA2A SCN8A	1.21e-03	9	174	2	C0235082
Disease	Senile Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0149840
Disease	Pill Rolling Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0751564
Disease	Tremor, Semirhythmic	ADORA2A SCN8A	1.21e-03	9	174	2	C0751565
Disease	Action Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234376
Disease	Passive Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234377
Disease	Static Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234378
Disease	Resting Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234379
Disease	Intermittent Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234372
Disease	Fine Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234373
Disease	Coarse Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234374
Disease	Massive Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234375
Disease	Persistent Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234370
Disease	Continuous Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234371
Disease	glycosyl-N-palmitoyl-sphingosine (d18:1/16:0) measurement	GABRB1 ATP10D	1.21e-03	9	174	2	EFO_0800476
Disease	Darkness Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0234381
Disease	Involuntary Quiver	ADORA2A SCN8A	1.21e-03	9	174	2	C1527384
Disease	Saturnine Tremor	ADORA2A SCN8A	1.21e-03	9	174	2	C0040827
Disease	Profound Mental Retardation	INPP5E TSEN54 CIC ADRA2B SCN8A	1.43e-03	139	174	5	C0020796
Disease	Mental Retardation, Psychosocial	INPP5E TSEN54 CIC ADRA2B SCN8A	1.43e-03	139	174	5	C0025363
Disease	Mental deficiency	INPP5E TSEN54 CIC ADRA2B SCN8A	1.43e-03	139	174	5	C0917816
Disease	arrhythmogenic right ventricular cardiomyopathy (is_implicated_in)	DSP DES	1.51e-03	10	174	2	DOID:0050431 (is_implicated_in)
Disease	Tremor	ADORA2A SCN8A	1.84e-03	11	174	2	C0040822
Disease	resting heart rate	DSP FMNL3 DES PPARGC1A MICAL2	1.94e-03	149	174	5	EFO_0004351
Disease	Childhood Medulloblastoma	MPL OTX2 IRS2	2.09e-03	43	174	3	C0278510
Disease	Melanotic medulloblastoma	MPL OTX2 IRS2	2.09e-03	43	174	3	C1275668
Disease	Medullomyoblastoma	MPL OTX2 IRS2	2.09e-03	43	174	3	C0205833
Disease	Desmoplastic Medulloblastoma	MPL OTX2 IRS2	2.09e-03	43	174	3	C0751291
Disease	Adult Medulloblastoma	MPL OTX2 IRS2	2.09e-03	43	174	3	C0278876
Disease	Gastrointestinal Diseases	MTR ABCC2	2.19e-03	12	174	2	C0017178
Disease	Functional Gastrointestinal Disorders	MTR ABCC2	2.19e-03	12	174	2	C0559031
Disease	Cholera Infantum	MTR ABCC2	2.19e-03	12	174	2	C1565321
Disease	complement component C7 measurement	MROH2B PLCXD3	2.19e-03	12	174	2	EFO_0008093
Disease	Charcot-Marie-Tooth Disease	SPTLC2 MORC2	2.19e-03	12	174	2	C0007959
Disease	Anxiety States, Neurotic	SHANK1 ADORA2A NPY	2.23e-03	44	174	3	C0376280
Disease	Anxiety neurosis (finding)	SHANK1 ADORA2A NPY	2.23e-03	44	174	3	C1279420
Disease	Anxiety Disorders	SHANK1 ADORA2A NPY	2.23e-03	44	174	3	C0003469
Disease	Schizophrenia	GABRB1 SHANK1 NUMBL NTF3 AMACR GRM3 CHRM1 CREB1 DICER1 ADORA2A PPARGC1A MTR NPY	2.32e-03	883	174	13	C0036341
Disease	Amino Acid Metabolism, Inherited Disorders	SLC7A7 EIF2AK4	2.58e-03	13	174	2	C0750905
Disease	complement component C6 measurement	MROH2B PLCXD3	2.58e-03	13	174	2	EFO_0020281
Disease	Amino Acid Metabolism, Inborn Errors	SLC7A7 EIF2AK4	2.58e-03	13	174	2	C0002514
Disease	forced expiratory volume	FILIP1 BMP2K PIEZO1 DOCK9 CKAP5 TSEN54 TRIM39 CHRM3 OTX1 SCMH1 TOP2B CACNA2D3	2.61e-03	789	174	12	EFO_0004314
Disease	chronic obstructive pulmonary disease	DSP TPRN PIEZO1 MBD1 TSEN54 CHRM3 DES SVIL VARS1 TOP2B CACNA2D3	2.68e-03	688	174	11	EFO_0000341
Disease	hearing impairment	NTF3 TPRN OTOF MYO15A	2.74e-03	98	174	4	C1384666
Disease	aspartate aminotransferase measurement	KIF21B SHROOM3 PIEZO1 DNAH2 NOX4 IL18RAP CHRM3 PPARGC1A BAZ2A ABCC2 MYO15A VARS1 MOV10	2.84e-03	904	174	13	EFO_0004736
Disease	status epilepticus (biomarker_via_orthology)	NTF3 ADAM9 ABCC2 NPY	2.95e-03	100	174	4	DOID:1824 (biomarker_via_orthology)
Disease	Generalized seizures	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0234533
Disease	Clonic Seizures	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0234535
Disease	Convulsive Seizures	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0751494
Disease	Seizures, Sensory	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0751496
Disease	Non-epileptic convulsion	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0751056
Disease	Atonic Absence Seizures	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0751123
Disease	Complex partial seizures	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0149958
Disease	Single Seizure	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0751110
Disease	Nonepileptic Seizures	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C3495874
Disease	Visual seizure	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0270824
Disease	Epileptic drop attack	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0270846
Disease	Vertiginous seizure	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0422855
Disease	Gustatory seizure	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0422854
Disease	Seizures, Somatosensory	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0422850
Disease	Olfactory seizure	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0422853
Disease	Seizures, Auditory	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0422852
Disease	Generalized Absence Seizures	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C4505436
Disease	Jacksonian Seizure	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C0022333
Disease	Epileptic Seizures	CHRM1 ADORA2A ABCC2 NPY	3.06e-03	101	174	4	C4317109
Disease	Absence Seizures	CHRM1 ADORA2A ABCC2 NPY	3.17e-03	102	174	4	C4316903
Disease	Convulsions	CHRM1 ADORA2A ABCC2 NPY	3.17e-03	102	174	4	C4048158
Disease	Tonic Seizures	CHRM1 ADORA2A ABCC2 NPY	3.17e-03	102	174	4	C0270844
Disease	Medulloblastoma	MPL OTX2 IRS2	3.22e-03	50	174	3	C0025149
Disease	Mood Disorders	NTF3 GRM3 CREB1 ADORA2A NPY	3.26e-03	168	174	5	C0525045
Disease	Seizures, Focal	CHRM1 ADORA2A ABCC2 NPY	3.40e-03	104	174	4	C0751495
Disease	Myoclonic Seizures	CHRM1 ADORA2A ABCC2 NPY	3.40e-03	104	174	4	C4317123
Disease	Tonic - clonic seizures	CHRM1 ADORA2A ABCC2 NPY	3.40e-03	104	174	4	C0494475
Disease	R-6-hydroxywarfarin measurement	RBM15 SHROOM3 DNAH2 MTR	4.71e-03	114	174	4	EFO_0803327
Disease	non-alcoholic fatty liver disease (is_implicated_in)	PPARGC1A ABCC2	4.97e-03	18	174	2	DOID:0080208 (is_implicated_in)
Disease	hypertension (is_implicated_in)	ADRA2B MTR NPY MOV10	5.81e-03	121	174	4	DOID:10763 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLEDSRYGRLPFSIR	ACO1	26	P21399
YIRRGQRSRPDLVEK	C2orf16	1231	Q68DN1
RSRRSPLKEGLKYSF	C2orf16	1931	Q68DN1
SLRSPGTLRVYLEER	MAMDC4	896	Q6UXC1
IRRPRNYSVGSRPLK	PFKFB2	476	O60825
DDGVKYLELRSTPRR	ADAL	96	Q6DHV7
PDLTRLKERYARTKR	ARHGEF10L	206	Q9HCE6
ITRVTPAYRLSRKQG	ATG13	131	O75143
PRAARVSRVARLKLY	CYB561D1	151	Q8N8Q1
DYRQVSKGLPRRLAT	COG7	746	P83436
YKTPKLLRTARGRRI	CATSPERD	741	Q86XM0
VLAPEKLSASTRRRY	EIF2AK4	1536	Q9P2K8
IRIPLRYNGLVTGTR	ADORA2A	106	P29274
RYSEEGLSPSKRRRL	BAZ2A	1776	Q9UIF9
YDVSRLGRGKRSLVL	AMACR	41	Q9UHK6
ALPLYRRTIRGRSLD	DPH6	66	Q7L8W6
APGTRRYTLAEKRET	GRM3	711	Q14832
TRPLTYRAKRTTKRA	CHRM3	171	P20309
RNSKERSLFPGSLRY	ARHGEF33	301	A8MVX0
EARKLLGLAYPERRR	ABCB10	156	Q9NRK6
RALEYNSKRTPRRIK	ADRA2B	116	P18089
YLIAKRSNRRGPRAK	ADRA2B	196	P18089
ALSYVLCKRRRGQSP	CXCL16	221	Q9H2A7
NFRRRKLYPPEDTTR	DICER1	786	Q9UPY3
KTLKPTYRTPERARR	BMP2K	1006	Q9NSY1
EPKAYRRRRSLSPLG	CDK13	306	Q14004
RSPYSPVLRRSGKSR	CDK13	396	Q14004
PVLRRSGKSRSRSPY	CDK13	401	Q14004
SLRPYRVLRDGTEKG	CFAP44	216	Q96MT7
RVLSRARSRPAKLYV	DAXX	111	Q9UER7
GPRYKRSKLERRANT	ATP10D	306	Q9P241
RQSLRRRKPAYVPEA	NUMBL	46	Q9Y6R0
LGYERTPSQCRERIK	MSANTD2	156	Q6P1R3
KIEAVYVSRRRSRSP	RBM15	246	Q96T37
YVSRRRSRSPLDKDT	RBM15	251	Q96T37
SRTRSRERDLVKPKY	RBM26	206	Q5T8P6
RSDGTRYITKRPVRD	PDZRN3	926	Q9UPQ7
DGTRYITKRPVRDRI	PDZRN4	896	Q6ZMN7
STTRLYLRKGRGETR	RAD51	296	Q06609
KALRQRLGPEYISSR	RAD52	41	P43351
LKLRARDPASRGDRY	INTS6L	36	Q5JSJ4
IGPRESAKEYRQRSL	P3H1	356	Q32P28
RDGPRRLKLHYNVTT	MELK	551	Q14680
APGTLKTLARYAVRR	ASB8	246	Q9H765
PEYLALRSVGIRREK	NOL9	256	Q5SY16
FRALKSRRDTPKYGL	NOP58	326	Q9Y2X3
YLTSNRLRSRALGPR	PODN	481	Q7Z5L7
IKRSRRGIFILSPNY	IL18RAP	471	O95256
KRRRTEEGPTLSYGR	MATR3	146	P43243
RKSQLVYQSRRGPLV	LGALS3BP	426	Q08380
APIRSKDVRSRSYLE	INPP5E	261	Q9NRR6
RKSQYLRSRMPEGTR	IL31RA	666	Q8NI17
PSREYATKTRIGIRR	GHITM	41	Q9H3K2
GYGRLRPRARSLSKA	MYO15A	116	Q9UKN7
LAARKRRQSEGTYSP	CRB2	1246	Q5IJ48
RISLDRSIPDYRPRK	GALNT9	126	Q9HCQ5
YRRVRKVGALDASPV	KCNG4	41	Q8TDN1
DRIRSKVELTRYLGP	MBD1	41	Q9UIS9
LRRPLKRNRITEGIY	MACO1	11	Q8N5G2
TEARRLYLQRKTVPS	AK8	101	Q96MA6
RAALSPLGRYRVLIK	PNMA6F	36	A0A0J9YX94
RLQGAEPSRLLRTYA	FAM157A	216	C9JC47
RILDRYQTSLPSRKG	KAT14	551	Q9H8E8
PLTRRKSYDRGQPIR	KIF21B	1216	O75037
KRDGRLNLASRLPSY	KDM3B	1516	Q7LBC6
YSTSAVLRRPQKGRL	PPFIA1	546	Q13136
YKAREPRLRVSLGTR	TUBGCP3	886	Q96CW5
KPLSSREAYGRALDR	GABRB1	406	P18505
RQLRRLDSVTRSPIY	ABCC2	1146	Q92887
SPVVANRTSRRKRYA	NTF3	126	P20783
YATLTRRPGRSALVR	CASKIN2	826	Q8WXE0
AYLRGSQKVPSRRTR	NOX4	81	Q9NPH5
YPATPRKQRRERTTF	OTX1	31	P32242
TYRRRASQKEREKPL	PIPSL	211	A2A3N6
NQPPSSELRYKRRRA	MORC2	476	Q9Y6X9
EKIRRTRGYSGLQRL	OASL	381	Q15646
LYRKIVTPFLSRRDS	PRR7	176	Q8TB68
TLSGLDPRRKYHVRL	PRTG	676	Q2VWP7
CRSKSERTPRQRSGY	GPR149	531	Q86SP6
QVRSPSLRYSRKENR	GPR149	646	Q86SP6
RRVIYVGKIRPDTTR	PPARGC1A	676	Q9UBK2
LYEVLRAGRKITPRL	MAP3K13	241	O43283
RRLPSDVVTGYLALR	INO80C	171	Q6PI98
LRKRTYSLTTPARQR	IRS2	571	Q9Y4H2
GRRNRVESLKLVTPY	PATL2	236	C9JE40
RTLPERSGVVCRVKY	PAF1	21	Q8N7H5
RASRCRPRSLIDYKS	FAM189A2	316	Q15884
KASNRRPSVYLPTRE	DDA1	26	Q9BW61
LRLQGAEPSRLLRTY	FAM157B	216	P0CG42
RPRLDAKIFRGQVYS	APOBEC3F	46	Q8IUX4
PGTRVNRYISRLLEA	ADCY1	561	Q08828
TFIKESPGLRRRRSE	APC2	1996	O95996
GPSVYLERLKILRQR	CKAP5	1931	Q14008
DRPIEKKSYSRARRT	CASC3	396	O15234
KAVRTTTRYAIRCGP	C2CD3	86	Q4AC94
LRRQGRYICSTVPAK	DOCK9	86	Q9BZ29
PDRKVRIFTYLIGRE	CACNA2D3	386	Q8IZS8
RTIPDTRDYRCLRKT	GALNT8	161	Q9NY28
ARQSVLRYSTLPGRR	FMNL3	196	Q8IVF7
LRYSTLPGRRALKNS	FMNL3	201	Q8IVF7
QTILGRRRYLPGIKD	POLQ	2441	O75417
SRPYLVELLSRRAGR	CRACD	981	Q6ZU35
ALYKAISVPRVRRAS	DSP	151	P15924
NRLKGREPTRVAELY	DES	141	P17661
TAALPTFRKLYARIR	TMEM30B	256	Q3MIR4
SVTRPLSYRAKRTPR	CHRM1	126	P11229
LTRERREAPRPYSKQ	ADAM9	51	Q13443
GRYIEARLGKPSLVR	ATAD3C	96	Q5T2N8
DSQKRREILSRRPSY	CREB1	106	P16220
PRALRQTYIRKVGDT	MYBPHL	56	A2RUH7
TSRRIGPELSRRIYL	EME1	541	Q96AY2
GFLKSALEVPRLYRR	COG2	581	Q14746
KTLKPTYRTPERARR	BMP2KL	256	Q5H9B9
SRNRPPIKTYEARSR	BICRA	1291	Q9NZM4
TSLLRYAGKKRRLQP	DNAH2	1981	Q9P225
GRKPHTVRLIIRRYS	POLI	361	Q9UNA4
ITYQIAKNRGLTPRR	UTP3	411	Q9NQZ2
RLPQYRKGLVRTSLA	IPO13	181	O94829
RSYRSTARTGLPRKT	MENT	46	Q9BUN1
PKAALSRDEILRYSR	MOCS3	51	O95396
YKIPLRNLVGRSIER	GARNL3	851	Q5VVW2
YPLERLGSVRRSVNL	MICAL2	496	O94851
TEKSYPERRLRGVLE	OTOF	751	Q9HC10
DKRRRSLPSSYRPAQ	PCARE	1006	A6NGG8
LTRSRRDGRKYPELV	PCDHB3	181	Q9Y5E6
SRRPSRLTVKYDRGQ	PPP1R14D	51	Q9NXH3
YPATPRKQRRERTTF	OTX2	31	P32243
IPSKGFQERRLSYRR	MPP3	286	Q13368
ATLGRLRRATEYAPK	MRPS31	131	Q92665
QRLRERRAASGYPVK	VARS1	1216	P26640
RLVEDKPGSRRRRSY	SRSF4	171	Q08170
LPETAVRGYRRFLKL	XAB2	161	Q9HCS7
VRGYRRFLKLSPESA	XAB2	166	Q9HCS7
SYLKRRGPQRSVDVI	PHTF2	621	Q8N3S3
KTSRYRSLRPNRQLG	TRIM39	71	Q9HCM9
LGTKSRTRYVRVQPA	SPON2	296	Q9BUD6
RLLSGYLPANTERRK	TBC1D22B	221	Q9NU19
FRVDLPIKSARYRGQ	SEC61A2	261	Q9H9S3
LKRLGYVVRRFQPSS	TSEN54	161	Q7Z6J9
RDSLLRRAAAERPKY	TOP2B	1356	Q02880
SKYAVPRRGSLERAN	SVIL	991	O95425
ALRRRSTSGLPDYRA	TMEM200C	466	A6NKL6
LELSKRYSRALRPSV	FILIP1	776	Q7Z7B0
RLSPRSVGVISPYRK	MOV10	821	Q9HCE1
LLEKPESSRGRRSYS	PHF7	351	Q9BWX1
VRRRESLSYIPKGLV	PLEKHG3	736	A1L390
ERRYLPLSQARKSGF	MTR	926	Q99707
QRRPTLQSLREKGYI	ARHGAP27	676	Q6ZUM4
RARGRPLGAVDKYRL	SIX4	196	Q9UIU6
RETRPRTKDRSGLYV	SIMC1	31	Q8NDZ2
GARRRLTPEQKKRSY	SHROOM3	1006	Q8TF72
SEKVGLYARTDRRPI	SIRT4	76	Q9Y6E7
GKSARLTPLRYDLRD	TENM1	2186	Q9UKZ4
PRRIIIRKTEYGSRL	ROR2	106	Q01974
LLSSSETKRAARRPY	MTA1	671	Q13330
AVLYDIGLPRSLRRS	MROH2B	261	Q7Z745
GSYLVRRSRRPQVTL	CYB5R1	26	Q9UHQ9
RRSGQRKPATSYVRT	RPL28	66	P46779
RRREPALEGVLSKYT	OSBPL10	71	Q9BXB5
RKLAGTLERGAPRRY	SPTBN5	3166	Q9NRC6
KLNRSPGSDRYLESR	SCMH1	566	Q96GD3
LGSRGRRRKLYSAVP	SHANK1	541	Q9Y566
DKVPYSSLRRTLDQR	CIC	1456	Q96RK0
EIAPGIIRKYRRNRT	CHST10	216	O43529
GIRYFDLRISTKPRD	PLCXD3	91	Q63HM9
RLITDPRSGRTYLKG	PLK3	51	Q9H4B4
IYRSLGDRPTLRTVK	SEMA6B	206	Q9H3T3
LKERISLPSRRSFYV	TPRA1	216	Q86W33
TVLLSGPRKGREVYR	RPL18	136	Q07020
KRESGRPLYLRLVTD	TEP1	1356	Q99973
LRSYLKRRGPQRSVD	PHTF1	596	Q9UMS5
FRVDLPIKSARYRGQ	SEC61A1	261	P61619
LLKDAIVYGQPRTRR	SPTLC2	291	O15270
HKRPLYLRRIVGSAT	SLC7A7	466	Q9UM01
INLITRQRYGKRSSP	NPY	56	P01303
RQRYGKRSSPETLIS	NPY	61	P01303
LFIPIRARERRSSYS	SCN8A	601	Q9UQD0
RKLSSGALYGRRPRS	SPATA7	191	Q9P0W8
RKYLACRGTEPTIRS	SCART1	191	Q4G0T1
RRIYRPKSLTGAKDL	TENM3	1236	Q9P273
SYRDLDKPRRSPTLR	PRPF38A	216	Q8NAV1
GGTLELRPRSRYRLQ	MPL	446	P40238
PRRGVKESVIALYRR	USP28	936	Q96RU2
LSDTRTRYLGSRPVK	SF3B3	686	Q15393
EYPSIRDKRSRLIEG	ZNF862	166	O60290
DGPRRIKRTYRPRSI	ZNF862	451	O60290
VSRLTERLRKRYPTN	ZFYVE27	331	Q5T4F4
LRVPGLAKNSREYVR	TPRN	436	Q4KMQ1
TASLRKLRAYRPSGQ	PIEZO1	326	Q92508
YRVDELQPGSRKRRT	WSCD1	231	Q658N2
PEAARYLERLIKLGR	THOP1	136	P52888
EVHGLRKRRLSYPLG	WDR81	106	Q562E7
SRRVEELSRPKRFYL	THEG	191	Q9P2T0
GAGELYRRKPRSRSL	TMEM101	126	Q96IK0
YRRKPRSRSLQSTGQ	TMEM101	131	Q96IK0
LDRRQALPTYRRVSA	UTF1	86	Q5T230
DTRIDPRLFRAGKYR	MYOM3	191	Q5VTT5