Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

3.38e-085313GO:0030156
GeneOntologyMolecularFunctioncalmodulin-dependent protein phosphatase activity

PPP3CA PPP3CC

2.33e-055312GO:0033192
GeneOntologyMolecularFunctioncalcium-dependent protein serine/threonine phosphatase activity

PPP3CA PPP3CC

6.49e-058312GO:0004723
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

ARMT1 NUDT12 PLCG1 PPP3CA PPP3CC CLN5

1.32e-03807316GO:0016788
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

ARMT1 PLCG1 PPP3CA PPP3CC

2.86e-03386314GO:0042578
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 RIMBP3C RIMBP3B

2.34e-0536323GO:0007274
GeneOntologyBiologicalProcessregulation of Rab protein signal transduction

DENND4A DENND4B

3.48e-056322GO:0032483
GeneOntologyBiologicalProcesscalcium-mediated signaling

PLCG1 PPP3CA PPP3CC ITGAL TRPM2

5.20e-05266325GO:0019722
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

PPP3CA PPP3CC TRPM2

5.59e-0548323GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

PPP3CA PPP3CC TRPM2

5.59e-0548323GO:1902656
GeneOntologyBiologicalProcessnegative regulation of calcium ion import across plasma membrane

PPP3CA PPP3CC

8.34e-059322GO:1905949
GeneOntologyBiologicalProcesspositive regulation of calcium-mediated signaling

PPP3CA PPP3CC ITGAL

1.73e-0470323GO:0050850
GeneOntologyBiologicalProcesspositive regulation of calcium ion import across plasma membrane

PPP3CA PPP3CC

1.80e-0413322GO:1905665
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

PLCG1 PPP3CA PPP3CC TRPM3 TRPM2

3.19e-04392325GO:0070588
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

PLCG1 PPP3CA PPP3CC TRPM2

3.40e-04217324GO:0097553
GeneOntologyBiologicalProcessregulation of calcium ion import across plasma membrane

PPP3CA PPP3CC

3.92e-0419322GO:1905664
GeneOntologyBiologicalProcesscalcium ion import

PPP3CA PPP3CC TRPM2

4.67e-0498323GO:0070509
GeneOntologyBiologicalProcesspositive regulation of calcineurin-mediated signaling

PPP3CA PPP3CC

4.81e-0421322GO:0106058
GeneOntologyBiologicalProcessRab protein signal transduction

DENND4A DENND4B

4.81e-0421322GO:0032482
GeneOntologyBiologicalProcessnegative regulation of calcium ion import

PPP3CA PPP3CC

4.81e-0421322GO:0090281
GeneOntologyBiologicalProcesspositive regulation of calcineurin-NFAT signaling cascade

PPP3CA PPP3CC

4.81e-0421322GO:0070886
GeneOntologyBiologicalProcesspositive regulation of calcium ion transmembrane transport

PLCG1 PPP3CA PPP3CC

6.37e-04109323GO:1904427
GeneOntologyBiologicalProcessfertilization

RIMBP3 RIMBP3C PPP3CC RIMBP3B

7.01e-04263324GO:0009566
GeneOntologyBiologicalProcessregulation of calcium-mediated signaling

PPP3CA PPP3CC ITGAL

8.63e-04121323GO:0050848
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

1.04e-0528323GO:0002177
GeneOntologyCellularComponentcalcineurin complex

PPP3CA PPP3CC

3.39e-056322GO:0005955
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

4.23e-0619243MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

5.80e-0621243MP:0008893
MousePhenodetached acrosome

RIMBP3 RIMBP3C RIMBP3B

5.62e-0544243MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C RIMBP3B

6.02e-0545243MP:0009376
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

1.16e-0456243MP:0009237
MousePhenoabnormal sperm nucleus morphology

RIMBP3 RIMBP3C RIMBP3B

2.66e-0474243MP:0009232
MousePhenoimpaired fertilization

RIMBP3 RIMBP3C PPP3CC RIMBP3B

3.86e-04206244MP:0000242
MousePhenoabnormal fertilization

RIMBP3 RIMBP3C PPP3CC RIMBP3B

5.04e-04221244MP:0005410
DomainMABP

DENND4A DENND4B

1.70e-054322IPR023341
DomainMABP

DENND4A DENND4B

1.70e-054322PS51498
DomainPPR

DENND4A DENND4B

7.91e-058322PS51375
DomainSer/Thr-sp_prot-phosphatase

PPP3CA PPP3CC

2.19e-0413322IPR006186
DomainSER_THR_PHOSPHATASE

PPP3CA PPP3CC

2.19e-0413322PS00125
DomainPP2Ac

PPP3CA PPP3CC

2.19e-0413322SM00156
DomainuDENN

DENND4A DENND4B

2.55e-0414322SM00800
DomainuDENN

DENND4A DENND4B

2.94e-0415322PF03456
DomainSH3_9

RIMBP3 RIMBP3C RIMBP3B

3.19e-0478323PF14604
DomainDENN

DENND4A DENND4B

3.36e-0416322PF02141
DomainUDENN

DENND4A DENND4B

3.36e-0416322PS50946
DomainDDENN

DENND4A DENND4B

3.36e-0416322PS50947
DomaindDENN_dom

DENND4A DENND4B

3.36e-0416322IPR005112
DomainuDENN_dom

DENND4A DENND4B

3.36e-0416322IPR005113
DomaindDENN

DENND4A DENND4B

3.36e-0416322PF03455
DomainDENN

DENND4A DENND4B

3.36e-0416322SM00799
DomainDENN

DENND4A DENND4B

3.36e-0416322PS50211
DomainDENN_dom

DENND4A DENND4B

3.36e-0416322IPR001194
DomaindDENN

DENND4A DENND4B

3.36e-0416322SM00801
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

4.25e-0486323IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

4.25e-0486323PF07653
DomainSH3

RIMBP3 RIMBP3C PLCG1 RIMBP3B

4.85e-04216324PS50002
DomainSH3

RIMBP3 RIMBP3C PLCG1 RIMBP3B

4.85e-04216324SM00326
DomainSH3_domain

RIMBP3 RIMBP3C PLCG1 RIMBP3B

5.20e-04220324IPR001452
DomainPentatricopeptide_repeat

DENND4A DENND4B

7.04e-0423322IPR002885
DomainNUDIX_BOX

NUDT12 TRPM2

7.67e-0424322PS00893
DomainPeptidase_M12B_ADAM-TS

ADAMTSL3 ADAMTS1

7.67e-0424322IPR013273
DomainNUDIX

NUDT12 TRPM2

9.01e-0426322PS51462
DomainCalcineurin-like_PHP_ApaH

PPP3CA PPP3CC

1.05e-0328322IPR004843
Domain-

NUDT12 TRPM2

1.05e-03283223.90.79.10
DomainMetallophos

PPP3CA PPP3CC

1.05e-0328322PF00149
DomainNUDIX_hydrolase_dom-like

NUDT12 TRPM2

1.05e-0328322IPR015797
DomainNUDIX_hydrolase_dom

NUDT12 TRPM2

1.12e-0329322IPR000086
DomainMetallo-depent_PP-like

PPP3CA PPP3CC

1.20e-0330322IPR029052
Domain-

PPP3CA PPP3CC

1.20e-03303223.60.21.10
DomainC1_1

CDC42BPA DGKK

4.28e-0357322PF00130
DomainFN3

RIMBP3 RIMBP3C RIMBP3B

4.71e-03199323PS50853
Domain-

RIMBP3 RIMBP3C VSIG10 RIMBP3B ADAMTSL3

5.05e-036633252.60.40.10
DomainTSP_1

ADAMTSL3 ADAMTS1

5.20e-0363322PF00090
DomainZF_DAG_PE_1

CDC42BPA DGKK

5.37e-0364322PS00479
DomainZF_DAG_PE_2

CDC42BPA DGKK

5.37e-0364322PS50081
DomainFN3_dom

RIMBP3 RIMBP3C RIMBP3B

5.39e-03209323IPR003961
DomainC1

CDC42BPA DGKK

5.53e-0365322SM00109
DomainTSP1

ADAMTSL3 ADAMTS1

5.53e-0365322SM00209
DomainTSP1_rpt

ADAMTSL3 ADAMTS1

5.53e-0365322IPR000884
DomainTSP1

ADAMTSL3 ADAMTS1

5.53e-0365322PS50092
DomainPE/DAG-bd

CDC42BPA DGKK

5.70e-0366322IPR002219
DomainIg-like_fold

RIMBP3 RIMBP3C VSIG10 RIMBP3B ADAMTSL3

6.57e-03706325IPR013783
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PLCG1 PPP3CA PPP3CC

2.72e-0616253M47449
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAQ_PLCB_G_CALCINEURIN

PLCG1 PPP3CA PPP3CC

3.30e-0617253M47560
PathwayBIOCARTA_CALCINEURIN_PATHWAY

PLCG1 PPP3CA PPP3CC

3.95e-0618253M3430
PathwayBIOCARTA_CALCINEURIN_PATHWAY

PLCG1 PPP3CA PPP3CC

3.95e-0618253MM1385
PathwayWP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS

PLCG1 PPP3CA PPP3CC

5.51e-0620253M48330
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCG1 PPP3CA PPP3CC

6.42e-0621253M47542
PathwayBIOCARTA_VIP_PATHWAY

PLCG1 PPP3CA PPP3CC

1.10e-0525253MM1441
PathwayBIOCARTA_VIP_PATHWAY

PLCG1 PPP3CA PPP3CC

1.25e-0526253M17941
PathwayBIOCARTA_GPCR_PATHWAY

PLCG1 PPP3CA PPP3CC

1.75e-0529253MM1495
PathwayBIOCARTA_GPCR_PATHWAY

PLCG1 PPP3CA PPP3CC

1.94e-0530253M9664
PathwayBIOCARTA_BCR_PATHWAY

PLCG1 PPP3CA PPP3CC

2.36e-0532253MM1355
PathwayBIOCARTA_BCR_PATHWAY

PLCG1 PPP3CA PPP3CC

2.60e-0533253M9494
PathwayBIOCARTA_FCER1_PATHWAY

PLCG1 PPP3CA PPP3CC

4.32e-0539253M1908
PathwayBIOCARTA_FCER1_PATHWAY

PLCG1 PPP3CA PPP3CC

4.32e-0539253MM1397
PathwayBIOCARTA_TCR_PATHWAY

PLCG1 PPP3CA PPP3CC

5.40e-0542253MM1504
PathwayBIOCARTA_TCR_PATHWAY

PLCG1 PPP3CA PPP3CC

6.22e-0544253M19784
PathwayKEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY

PLCG1 PPP3CA PPP3CC ITGAL

9.22e-05137254M5669
PathwayKEGG_MEDICUS_REFERENCE_LYSOSOMAL_CA2_RELEASE

PPP3CA PPP3CC

1.35e-0410252M47954
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_CN_SIGNALING_PATHWAY

PPP3CA PPP3CC

1.97e-0412252M47956
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

POMT1 ADAMTSL3 ADAMTS1

2.29e-0468253M27303
PathwayBIOCARTA_PGC1A_PATHWAY

PPP3CA PPP3CC

2.71e-0414252MM1473
PathwayBIOCARTA_PGC1A_PATHWAY

PPP3CA PPP3CC

3.13e-0415252M15181
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

PPP3CA PPP3CC

3.13e-0415252MM1387
PathwayKEGG_VEGF_SIGNALING_PATHWAY

PLCG1 PPP3CA PPP3CC

3.18e-0476253M1749
PathwayBIOCARTA_MEF2D_PATHWAY

PPP3CA PPP3CC

3.57e-0416252MM1483
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

PPP3CA PPP3CC

4.04e-0417252M5940
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CC

4.54e-0418252M47580
PathwayBIOCARTA_MEF2D_PATHWAY

PPP3CA PPP3CC

4.54e-0418252M5290
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PPP3CA PPP3CC

5.07e-0419252M47543
PathwayBIOCARTA_NOS1_PATHWAY

PPP3CA PPP3CC

5.63e-0420252MM1445
PathwayBIOCARTA_NOS1_PATHWAY

PPP3CA PPP3CC

6.21e-0421252M11650
PathwayREACTOME_DARPP_32_EVENTS

PPP3CA PPP3CC

8.14e-0424252M751
PathwayBIOCARTA_HDAC_PATHWAY

PPP3CA PPP3CC

8.83e-0425252M1547
PathwayKEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY

PLCG1 PPP3CA PPP3CC

8.90e-04108253M9904
PathwayREACTOME_O_LINKED_GLYCOSYLATION

POMT1 ADAMTSL3 ADAMTS1

9.14e-04109253MM15164
PathwayBIOCARTA_HDAC_PATHWAY

PPP3CA PPP3CC

9.56e-0426252MM1371
PathwayREACTOME_O_LINKED_GLYCOSYLATION

POMT1 ADAMTSL3 ADAMTS1

9.63e-04111253M27416
PathwayREACTOME_TRP_CHANNELS

TRPM3 TRPM2

1.11e-0328252MM14943
PathwayWP_T_CELL_RECEPTOR_AND_COSTIMULATORY_SIGNALING

PLCG1 PPP3CA

1.11e-0328252M39632
PathwayREACTOME_TRP_CHANNELS

TRPM3 TRPM2

1.11e-0328252M27241
PathwayWP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR

PPP3CA PPP3CC

1.45e-0332252M39521
PathwayBIOCARTA_FMLP_PATHWAY

PPP3CA PPP3CC

1.64e-0334252M10287
PathwayBIOCARTA_FMLP_PATHWAY

PPP3CA PPP3CC

1.64e-0334252MM1399
PathwayWP_LEUKOCYTEINTRINSIC_HIPPO_PATHWAY_FUNCTIONS

MST1 ITGAL

1.73e-0335252M39430
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

POMT1 ADAMTSL3 ADAMTS1

2.00e-03143253M27275
PathwayWP_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS

PPP3CA PPP3CC

2.04e-0338252M39357
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL3 ADAMTS1

2.15e-0339252M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL3 ADAMTS1

2.15e-0339252MM15165
PathwaySIG_BCR_SIGNALING_PATHWAY

PPP3CA PPP3CC

2.98e-0346252M8626
PathwayWP_ENERGY_METABOLISM

PPP3CA PPP3CC

3.24e-0348252M39590
PathwayBIOCARTA_NFAT_PATHWAY

PPP3CA PPP3CC

3.37e-0349252MM1442
PathwayBIOCARTA_NFAT_PATHWAY

PPP3CA PPP3CC

3.65e-0351252M2288
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

PLCG1 PPP3CA PPP3CC

3.71e-03178253M2890
PathwayKEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS

PPP3CA PPP3CC

3.94e-0353252M3812
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

MST1 PLCG1

4.23e-0355252M47952
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

PLCG1 PPP3CA

4.70e-0358252MM14914
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

2.83e-09432319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

7.07e-09532317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

2.56e-071432317662146
Pubmed

Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.

PLCG1 PPP3CA PPP3CC

1.24e-062332320379146
Pubmed

Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges.

DENND4A DENND4B

2.46e-06332212906859
Pubmed

Oxidative stress mediates the disruption of airway epithelial tight junctions through a TRPM2-PLCγ1-PKCα signaling pathway.

PLCG1 TRPM2

2.46e-06332223629676
Pubmed

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

PPP3CA PPP3CC

2.46e-06332219154138
Pubmed

Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.

PPP3CA PPP3CC

2.46e-0633222162844
Pubmed

Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit.

PPP3CA PPP3CC

2.46e-0633221659808
Pubmed

Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin.

PLCG1 PPP3CA

4.92e-06432219717566
Pubmed

Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.

PPP3CA PPP3CC

4.92e-06432211714752
Pubmed

Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes.

PPP3CA PPP3CC

4.92e-0643221318721
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

PLCG1 PPP3CA PPP3CC

5.84e-063832312482669
Pubmed

TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics.

CKB PPP3CA CLN5

5.84e-063832329715546
Pubmed

Calcineurin: form and function.

PPP3CA PPP3CC

8.19e-06532211015619
Pubmed

Are calcineurin genes associated with endurance phenotype traits?

PPP3CA PPP3CC

8.19e-06532220107831
Pubmed

Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.

PPP3CA PPP3CC

8.19e-06532220593291
Pubmed

Elevated expression of calcineurin subunits during active mineralization of developing mouse molar teeth.

PPP3CA PPP3CC

8.19e-06532222984995
Pubmed

The Sensory Coding of Warm Perception.

TRPM3 TRPM2

8.19e-06532232208171
Pubmed

A synaptic temperature sensor for body cooling.

TRPM3 TRPM2

1.23e-05632234672983
Pubmed

Mammalian brain phosphoproteins as substrates for calcineurin.

PPP3CA PPP3CC

1.23e-0563226330098
Pubmed

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.

PPP3CA PPP3CC

1.23e-05632210195903
Pubmed

The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton.

PPP3CA PPP3CC

1.72e-05732228126489
Pubmed

Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity.

PPP3CA PPP3CC

1.72e-0573228631904
Pubmed

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.

PLCG1 TESPA1

1.72e-05732222561606
Pubmed

Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A.

PPP3CA PPP3CC

1.72e-05732211123943
Pubmed

AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.

PPP3CA PPP3CC

2.29e-05832217640527
Pubmed

Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

PPP3CA PPP3CC

2.94e-05932222343722
Pubmed

SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PPP3CA PPP3CC

2.94e-05932234446558
Pubmed

A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.

PPP3CA PPP3CC

5.38e-051232215757646
Pubmed

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.

TRPM3 TRPM2

5.38e-051232219850157
Pubmed

Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.

PPP3CA PPP3CC

7.41e-051432228826478
Pubmed

Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.

PPP3CA PPP3CC

8.55e-051532221047202
Pubmed

Channel-interacting PDZ protein, 'CIPP', interacts with proteins involved in cytoskeletal dynamics.

CKB PPP3CA

9.76e-051632219138174
Pubmed

Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.

PPP3CA PPP3CC

1.11e-041732224086760
Pubmed

Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.

TRPM3 TRPM2

1.24e-041832231911949
Pubmed

Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.

PPP3CA PPP3CC

1.70e-042132231696965
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPM3 TRPM2

2.24e-042432233884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPM3 TRPM2

2.43e-042532216382100
Pubmed

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

RIMBP3 MST1 ITGAL SBNO2

2.66e-0434232423128233
Pubmed

Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.

CKB PPP3CA

2.84e-042732216800626
Pubmed

An introduction to TRP channels.

TRPM3 TRPM2

2.84e-042732216460286
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PLCG1 POMT1 PPP3CA CDC42BPA TULP4 SBNO2 TRPM2

3.41e-04148932728611215
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPM3 TRPM2

4.25e-043332219834762
Pubmed

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

DENND4A DENND4B

5.35e-043732220937701
Pubmed

Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.

MST1 SBNO2

5.95e-043932219760754
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPM3 TRPM2

7.57e-044432219322198
Pubmed

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.

PLCG1 ITGAL

8.28e-044632223793062
InteractionRCAN3 interactions

ARMT1 PPP3CA PPP3CC

2.65e-0618313int:RCAN3
InteractionRCAN2 interactions

ARMT1 PPP3CA PPP3CC

6.53e-0624313int:RCAN2
InteractionC16orf74 interactions

PPP3CA PPP3CC

4.79e-057312int:C16orf74
InteractionRCAN1 interactions

ARMT1 PPP3CA PPP3CC

6.92e-0552313int:RCAN1
InteractionARMT1 interactions

ARMT1 PPP3CA PPP3CC

1.48e-0467313int:ARMT1
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

6.48e-0511132322q11.21
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 RIMBP3C RIMBP3B

3.08e-03419323chr22q11
CytobandEnsembl 112 genes in cytogenetic band chr6q25

ARMT1 TULP4

5.86e-03164322chr6q25
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP3CA PPP3CC

7.25e-0513182693
GeneFamilyNudix hydrolase family

NUDT12 TRPM2

2.55e-0424182667
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND4A DENND4B

2.77e-0425182504
GeneFamilyTransient receptor potential cation channels

TRPM3 TRPM2

3.48e-0428182249
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

VSIG10 ADAMTSL3

1.10e-02161182593
GeneFamilyImmunoglobulin like domain containing

VSIG10 ADAMTSL3

1.55e-02193182594
CoexpressionAtlasalpha beta T cells, NKT.4-.Sp, TCRbeta+ aGalCer tet+ CD4-, Spleen, avg-3

CKB DENND4A PLCG1 PPP3CC ITGAL TESPA1

8.83e-06331326GSM538329_500
CoexpressionAtlasalpha beta T cells, NKT.4+.Lv, CD45 TCRb aGalCer-loaded CD1d tet CD4, Liver, avg-4

CKB DENND4A PLCG1 PPP3CC ITGAL TESPA1

1.21e-05350326GSM538318_500
CoexpressionAtlasalpha beta T cells, NKT.4-.Lv, CD45 TCRb aGalCer-loaded CD1d tet, Liver, avg-4

CKB DENND4A PLCG1 PPP3CC ITGAL TESPA1

1.23e-05351326GSM538325_500
CoexpressionAtlasalpha beta T cells, NKT.4+.Sp, TCRb aGalCer-loaded CD1d tetramer CD4, Spleen, avg-1

CKB PLCG1 PPP3CC ITGAL TESPA1

1.59e-04347325GSM538322_500
CoexpressionAtlasalpha beta T cells, T.4Mem44h62l.Sp, CD4 TCRb CD44hi CD62Llo, Spleen, avg-3

CKB PLCG1 PPP3CC ITGAL TESPA1

1.86e-04359325GSM538371_500
CoexpressionAtlasalpha beta T cells, T.8Mem.Sp.OT1.d100.LisOva, CD8+ CD45.1+, Spleen, avg-3

DENND4A PLCG1 PPP3CC ITGAL TESPA1

2.01e-04365325GSM605904_500
CoexpressionAtlasalpha beta T cells, T.4SP69+.Th, 4+ 8- TCRhi 69+, Thymus, avg-3

CKB PLCG1 ITGAL TULP4 TESPA1

2.01e-04365325GSM399376_500
CoexpressionAtlasalpha beta T cells, T.8Mem.Sp.OT1.d106.VSVOva, CD8+ CD45.1+, Spleen, avg-2

DENND4A PLCG1 PPP3CC ITGAL TESPA1

2.06e-04367325GSM538401_500
CoexpressionAtlasalpha beta T cells, T.8Mem.Sp.OT1.d45.LisOva, CD8+ CD45.1+, Spleen, avg-2

DENND4A PLCG1 PPP3CC ITGAL TESPA1

2.51e-04383325GSM605907_500
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A PPP3CC ITGAL TESPA1

5.13e-06160324398f162e8a75c6cb5c3e4d1832e98d386e1f222b
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-CD45____NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A PPP3CC ITGAL TESPA1

5.13e-0616032412aaab0291035f578e2433efd169ae72f393a5a5
ToppCellfacs-GAT-Fat-3m-Lymphocytic|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A PPP3CC ITGAL TESPA1

7.47e-061763242e3f25a338842384517656d05776a52cbfc62b52
ToppCellfacs-GAT-Fat-3m-Lymphocytic-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A PPP3CC ITGAL TESPA1

7.47e-061763240823088bc6b19c7ad784d83c2ccdfae80611afab
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

PLCG1 ITGAL ADAMTS1 DGKK

1.24e-052003242281debd86e5d92e8fe0397aec9ef670800f7471
DrugL-685-818

PPP3CA PPP3CC ITGAL

3.13e-0622303CID000003850
DrugLuveniq

PPP3CA PPP3CC ITGAL

4.66e-0625303CID006918486
DrugLX201

PPP3CA PPP3CC

1.01e-054302CID006440291
Drugsuppressor of FK506 1

PPP3CA PPP3CC

1.01e-054302CID000419462
Drugbotrydial

PPP3CA PPP3CC

1.67e-055302CID000185781
Drug1-benzothiophene-2-carboxamide

PPP3CA PPP3CC

3.51e-057302CID000237073
Drug2,2,2-trifluoroethyl phosphate

PPP3CA PPP3CC

3.51e-057302CID000151044
DrugBAPTA

PLCG1 PPP3CA PPP3CC TRPM3 TRPM2

6.02e-05324305CID000104751
Drug1-norokadaone

PPP3CA PPP3CC

1.10e-0412302CID003309928
DrugINCA-6

PPP3CA PPP3CC

1.10e-0412302CID000230748
Drugendothall thioanhydride

PPP3CA PPP3CC

1.10e-0412302CID000176108
Drugnicotinoylprocaine

CKB GANC

1.10e-0412302CID000159667
Drugestradiol, USP; Up 200; 0.1uM; HL60; HT_HG-U133A

PLCG1 VSIG10 TRPM3 ADAMTS1

1.20e-041953042668_UP
Drug(R) -Naproxen sodium salt [26159-34-2]; Down 200; 15.8uM; PC3; HT_HG-U133A

PPP3CC TULP4 ADAMTSL3 CLN5

1.25e-041973047146_DN
DrugGuanfacine hydrochloride [29110-48-3]; Up 200; 14.2uM; HL60; HT_HG-U133A

DENND4A CDC42BPA PPP3CC CLN5

1.25e-041973041279_UP
DrugThiamphenicol [15318-45-3]; Down 200; 11.2uM; PC3; HT_HG-U133A

PLCG1 CDC42BPA PPP3CC SBNO2

1.27e-041983041826_DN
DrugTrazodone hydrochloride [25332-39-2]; Down 200; 9.8uM; MCF7; HT_HG-U133A

CDC42BPA PPP3CC TULP4 SBNO2

1.32e-042003047410_DN
Diseasetonsillectomy risk measurement

MGMT ITGAL TRPM3 SBNO2

1.18e-04260294EFO_0007924
DiseaseLeft Ventricular Hypertrophy

CKB PPP3CA

2.76e-0425292C0149721
Diseaseschizophrenia (is_marker_for)

PPP3CA PPP3CC

8.60e-0444292DOID:5419 (is_marker_for)
DiseaseCrohn's disease

MST1 NUDT12 TRPM3 SBNO2

8.69e-04441294EFO_0000384
Diseasedehydroepiandrosterone sulphate measurement

TECRL MGMT

2.04e-0368292EFO_0007001
Diseaseserum metabolite measurement

TECRL PPP3CA CDC42BPA MGMT TESPA1

2.09e-03945295EFO_0005653
DiseaseNonorganic psychosis

PPP3CC TRPM2

2.10e-0369292C0349204
Diseaseanorexia nervosa

PPP3CA MGMT

2.16e-0370292MONDO_0005351
Diseasecardiomyopathy (implicated_via_orthology)

PPP3CA PPP3CC

2.22e-0371292DOID:0050700 (implicated_via_orthology)
Diseaseankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis

MST1 ITGAL SBNO2

2.98e-03295293EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268
DiseasePsychotic Disorders

PPP3CC TRPM2

4.43e-03101292C0033975

Protein segments in the cluster

PeptideGeneStartEntry
WTLPHEYCAMPQVAP

ARMT1

336

Q9H993
VSMIFPFHWPCPYVP

DENND4A

436

Q7Z401
FMCHRWPETPPFSYT

RIMBP3B

1186

A6NNM3
FMCHRWPETPPFSYT

RIMBP3C

1186

A6NJZ7
NLDHSQPWSPCSAYM

ADAMTS1

436

Q9UHI8
PAAENNPFLVGMHCW

DGKK

316

Q5KSL6
FMWNPHLGYILTCPS

CKB

271

P12277
PEPLMQCTAWLNAYF

MGMT

56

P16455
TCVPMNHLWPDQAPY

OGDHL

686

Q9ULD0
AMPPLFSLGYHQCRW

GANC

356

Q8TET4
PVPCWLHSHQDTYPM

POMT1

336

Q9Y6A1
VSMIFPLHWQCPYIP

DENND4B

441

O75064
SHGPWCYTMDPRTPF

MST1

426

P26927
LLAEYCEWLPQAMHP

DHX37

1131

Q8IY37
CSPHPYWLPNFMDVF

PPP3CA

336

Q08209
YFNPWNCPAPMTLCP

TRIM34

471

Q9BYJ4
FMCHRWPETPPFSYT

RIMBP3

1186

Q9UFD9
SPPPLQSAMLHCPYW

SBNO2

26

Q9Y2G9
HVQYVACQPWPMPSS

NUDT12

381

Q9BQG2
HQWSVQMEPPVPCHY

ITGAL

986

P20701
LMWPANPSSCCYNAP

CDC42BPA

1446

Q5VT25
FPHLRPEMDAPFWCN

CLN5

146

O75503
NCSPHPYWLPNFMDV

PPP3CC

331

P48454
HPWSSYSACPPMQNP

TULP4

1261

Q9NRJ4
ECQNPWDSEPPMYHT

TRPM3

1506

Q9HCF6
CFGPNHTLYPMVTRW

TRPM2

1341

O94759
AVCPDTMNNPLSHYW

PLCG1

316

P19174
ICPHFPQDFWPEQSM

ZNF91

86

Q05481
YYPPPSAPQCWAQMA

VSIG10

221

Q8N0Z9
PSHMFWNCNHPTDVP

TESPA1

251

A2RU30
ACFPSPNYNPFTWMF

TECRL

281

Q5HYJ1
MPYDHFQPLPRWEHN

ADAMTSL3

411

P82987