Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendopeptidase activity

ADAM12 ADAM19 CORIN

1.89e-03430123GO:0004175
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAM12 ADAM19

2.27e-03120122GO:0004222
GeneOntologyMolecularFunctionSH3 domain binding

ADAM12 ADAM19

3.21e-03143122GO:0017124
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAM12 ADAM19

6.17e-03200122GO:0008237
GeneOntologyMolecularFunctionpeptidase activity

ADAM12 ADAM19 CORIN

6.17e-03654123GO:0008233
GeneOntologyCellularComponentextracellular matrix

ADAM19 FCGBP VWF OTOGL

3.89e-04656124GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAM19 FCGBP VWF OTOGL

3.94e-04658124GO:0030312
MousePhenointestinal obstruction

SLIT3 SPRY2

5.10e-0514112MP:0003270
MousePhenothin diaphragm muscle

ADAM19 SLIT3

1.95e-0427112MP:0000761
MousePhenocardiac hypertrophy

ADAM19 SLIT3 CORIN

4.12e-04196113MP:0001625
MousePhenoheart right ventricle hypertrophy

ADAM19 SLIT3

4.76e-0442112MP:0000276
MousePhenoabnormal gastrointestinal motility

SLIT3 SPRY2

7.31e-0452112MP:0011082
MousePhenoabnormal heart right ventricle wall morphology

ADAM19 SLIT3

7.31e-0452112MP:0031534
MousePhenoincreased heart right ventricle size

ADAM19 SLIT3

8.17e-0455112MP:0010563
MousePhenohemorrhage

TCTN1 ADAM19 VWF SLIT3

1.27e-03664114MP:0001914
MousePhenoabnormal diaphragm morphology

ADAM19 SLIT3

1.64e-0378112MP:0002279
MousePhenoabnormal heart right ventricle size

ADAM19 SLIT3

1.64e-0378112MP:0010577
MousePhenoabnormal blood circulation

TCTN1 ADAM19 VWF SLIT3

3.11e-03845114MP:0002128
MousePhenoabnormal primary cilium morphology

TCTN1 SPRY2

3.46e-03114112MP:0013203
DomainEGF-like_dom

ADAM12 ADAM19 FCGBP SLIT3 TENM2

1.75e-07249115IPR000742
DomainEGF_3

ADAM12 ADAM19 SLIT3 TENM2

7.52e-06235114PS50026
DomainEGF_1

ADAM12 ADAM19 SLIT3 TENM2

1.04e-05255114PS00022
DomainEGF-like_CS

ADAM12 ADAM19 SLIT3 TENM2

1.14e-05261114IPR013032
DomainEGF_2

ADAM12 ADAM19 SLIT3 TENM2

1.21e-05265114PS01186
DomainTIL

FCGBP VWF

2.07e-0512112PF01826
DomainC8

FCGBP VWF

2.07e-0512112PF08742
DomainC8

FCGBP VWF

2.45e-0513112SM00832
DomainUnchr_dom_Cys-rich

FCGBP VWF

2.45e-0513112IPR014853
DomainTIL_dom

FCGBP VWF

2.86e-0514112IPR002919
DomainVWFD

FCGBP VWF

3.77e-0516112PS51233
DomainVWD

FCGBP VWF

3.77e-0516112SM00216
DomainVWF_type-D

FCGBP VWF

3.77e-0516112IPR001846
DomainVWD

FCGBP VWF

3.77e-0516112PF00094
DomainDisintegrin_CS

ADAM12 ADAM19

3.77e-0516112IPR018358
DomainADAM_CR

ADAM12 ADAM19

4.80e-0518112PF08516
DomainCTCK_1

VWF SLIT3

4.80e-0518112PS01185
DomainVWC_out

FCGBP VWF

5.36e-0519112SM00215
Domain-

ADAM12 ADAM19

5.96e-05201124.10.70.10
DomainDISIN

ADAM12 ADAM19

6.58e-0521112SM00050
DomainDisintegrin

ADAM12 ADAM19

6.58e-0521112PF00200
DomainCT

VWF SLIT3

7.24e-0522112SM00041
DomainCys_knot_C

VWF SLIT3

9.39e-0525112IPR006207
DomainCTCK_2

VWF SLIT3

9.39e-0525112PS01225
DomainADAM_Cys-rich

ADAM12 ADAM19

1.10e-0427112IPR006586
DomainACR

ADAM12 ADAM19

1.10e-0427112SM00608
DomainVWC

FCGBP VWF

2.19e-0438112SM00214
DomainPep_M12B_propep

ADAM12 ADAM19

2.31e-0439112PF01562
DomainPeptidase_M12B_N

ADAM12 ADAM19

2.31e-0439112IPR002870
DomainDISINTEGRIN_1

ADAM12 ADAM19

2.43e-0440112PS00427
DomainReprolysin

ADAM12 ADAM19

2.43e-0440112PF01421
DomainADAM_MEPRO

ADAM12 ADAM19

2.43e-0440112PS50215
DomainDISINTEGRIN_2

ADAM12 ADAM19

2.43e-0440112PS50214
DomainPeptidase_M12B

ADAM12 ADAM19

2.43e-0440112IPR001590
DomainDisintegrin_dom

ADAM12 ADAM19

2.55e-0441112IPR001762
DomainVWF_dom

FCGBP VWF

2.68e-0442112IPR001007
DomainEGF

FCGBP SLIT3 TENM2

3.01e-04235113SM00181
DomainEGF_extracell

ADAM12 ADAM19

5.48e-0460112IPR013111
DomainEGF_2

ADAM12 ADAM19

5.48e-0460112PF07974
Domain-

ADAM12 ADAM19

9.96e-04811123.40.390.10
DomainMetalloPept_cat_dom

ADAM12 ADAM19

9.96e-0481112IPR024079
DomainZINC_PROTEASE

ADAM12 ADAM19

1.45e-0398112PS00142
DomainEGF_CA

SLIT3 TENM2

2.24e-03122112SM00179
DomainEGF-like_Ca-bd_dom

SLIT3 TENM2

2.31e-03124112IPR001881
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAM12 ADAM19 VWF

4.69e-0425893MM14572
PathwayREACTOME_SIGNALING_BY_EGFR

ADAM12 SPRY2

4.91e-045392M27039
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

ADAM12 ADAM19 VWF

7.29e-0430093M610
Pubmed

A metalloprotease-disintegrin participating in myoblast fusion.

ADAM12 ADAM19

3.27e-0731227566181
Pubmed

Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells.

ADAM12 ADAM19

3.27e-0731229461614
Pubmed

Spatially- and temporally-restricted expression of meltrin alpha (ADAM12) and beta (ADAM19) in mouse embryo.

ADAM12 ADAM19

3.27e-0731229622634
Pubmed

The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells.

ADAM12 ADAM19

6.55e-07412212615925
Pubmed

Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.

VWF CORIN

6.55e-07412222437503
Pubmed

Selective modulation of integrin-mediated cell migration by distinct ADAM family members.

ADAM12 ADAM19

6.55e-07412216079176
Pubmed

Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2.

ADAM12 ADAM19

1.09e-06512215936750
Pubmed

Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets.

SLIT3 TENM2

3.05e-06812219563800
Pubmed

Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.

ADAM12 ADAM19

3.05e-06812224103556
Pubmed

Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19.

ADAM12 ADAM19

3.05e-06812217344430
Pubmed

Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.

ADAM12 ADAM19

3.05e-06812210527948
Pubmed

Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.

ADAM12 ADAM19

1.86e-051912215063736
Pubmed

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.

ADAM12 ADAM19

3.00e-052412225825872
Pubmed

Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis.

VWF SPRY2

6.08e-053412221172336
Pubmed

Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.

ADAM12 VWF SLIT3

7.51e-0524812324006456
Pubmed

Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia.

VWF SPRY2

8.03e-053912230566624
Pubmed

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.

SLIT3 CORIN

1.07e-044512222696295
InteractionADAM8 interactions

ADAM12 ADAM19

1.78e-0511122int:ADAM8
InteractionADAM23 interactions

ADAM12 ADAM19

3.88e-0516122int:ADAM23
InteractionADAM2 interactions

ADAM12 ADAM19

4.40e-0517122int:ADAM2
InteractionADAM28 interactions

ADAM12 ADAM19

4.95e-0518122int:ADAM28
InteractionADAM11 interactions

ADAM12 ADAM19

1.80e-0434122int:ADAM11
InteractionADAM7 interactions

ADAM12 ADAM19

2.90e-0443122int:ADAM7
InteractionADAM22 interactions

ADAM12 ADAM19

3.32e-0446122int:ADAM22
InteractionADAM19 interactions

ADAM12 ADAM19

3.61e-0448122int:ADAM19
InteractionADAM12 interactions

ADAM12 ADAM19

5.27e-0458122int:ADAM12
InteractionMAPKBP1 interactions

ADAM12 SPRY2

8.57e-0474122int:MAPKBP1
InteractionHOXA1 interactions

ADAM12 VWF SPRY2

1.07e-03356123int:HOXA1
InteractionSPRY4 interactions

ADAM12 SPRY2

1.16e-0386122int:SPRY4
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM12 ADAM19

3.21e-05276247
CoexpressionNABA_MATRISOME

ADAM12 ADAM19 VWF SLIT3 OTOGL

5.26e-051008125MM17056
CoexpressionIL2_UP.V1_UP

TM4SF1 ADAM19 SPRY2

7.86e-05190123M2822
CoexpressionNABA_ECM_GLYCOPROTEINS

VWF SLIT3 OTOGL

7.98e-05191123MM17059
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_k-means-cluster#1_top-relative-expression-ranked_500

ADAM12 TENM2 CORIN

6.16e-05142123gudmap_developingKidney_e13.5_podocyte cells_500_k1
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_200

TM4SF1 SLIT3 CORIN

1.19e-04177123gudmap_kidney_P0_JuxtaGlom_Ren1_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder mesenchyme_emap-3087_k-means-cluster#4_top-relative-expression-ranked_100

ADAM12 VWF

1.26e-0430122gudmap_developingLowerUrinaryTract_e13.5_bladder mesenchyme_100_k4
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tfh|Liver / Manually curated celltypes from each tissue

ADAM12 TM4SF1 FCGBP

8.79e-0615612385bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLIT3 TENM2 CORIN

1.12e-05169123335619507857383c3b0b507cdf05d786ed59e585
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAM12 SLIT3 OTOGL

1.14e-051701235570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF SPRY2

1.30e-051781235cc182e6faa7ba5b88378d2c953be29bbbb95a7e
ToppCellfacs-Lung-Endomucin-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF SPRY2

1.30e-05178123f9a16bc3f09c35c7d30e3809da024bc2dcf746ed
ToppCellfacs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TM4SF1 VWF CORIN

1.35e-0518012367c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TM4SF1 SLIT3 CORIN

1.42e-051831234060d979948e1dd7507977629a7fbdfa4ca65bb6
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-1|TCGA-Thryoid / Sample_Type by Project: Shred V9

ADAM12 ADAM19 CORIN

1.42e-0518312306e4b05d86a7d643569e19575c2c9aa351d33f29
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAM19 FCGBP SPRY2

1.42e-05183123d1bf3abf42eb9d7facf775becf1338d1faadd647
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TM4SF1 SLIT3 CORIN

1.42e-051831230d44a978221cf3f733704bf11863502805fba733
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADAM19 FCGBP SPRY2

1.42e-05183123bd78e5c2670e67b4363078e3ca5a5b7081d24b7e
ToppCellIPF-Myeloid-DC_Langerhans|Myeloid / Disease state, Lineage and Cell class

ADAM19 FCGBP SLIT3

1.46e-05185123ced17f69486591c3cbbdc852a3e82c3f3a4a30d7
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ADAM12 SLIT3 TENM2

1.49e-0518612356c139e679d640ea901ead657a8e8887e0fca098
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2|TCGA-Kidney / Sample_Type by Project: Shred V9

ADAM12 ADAM19 SLIT3

1.49e-051861231e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TM4SF1 ADAM19 VWF

1.54e-0518812326915db8863f4115b46a81982e187322e21600fd
ToppCellfacs-Pancreas-Endocrine-3m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 TM4SF1 SLIT3

1.54e-05188123da862ea3c74f42d0dbae38b09211a45c593d477e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TM4SF1 ADAM19 VWF

1.54e-051881233f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCellfacs-Pancreas-Endocrine-3m-Endothelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 TM4SF1 SLIT3

1.54e-05188123b82a7667ef74a05e8bc744f6c090a7cc7b8efe32
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TM4SF1 ADAM19 VWF

1.54e-0518812361ee7b152745164293d8a44ef91ee2393efbdca5
ToppCellfacs-Pancreas-Endocrine-3m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 TM4SF1 SLIT3

1.54e-0518812319672d284fe89c9c3c7697514ca1f659329c34f4
ToppCell368C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TCTN1 FCGBP SLIT3

1.66e-051931235f5904cec8b2967154ef2eab3c48f51df53aca4a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM12 SLIT3 CORIN

1.69e-05194123ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

ADAM19 SLIT3 OTOGL

1.69e-0519412389812fb164065041357bb37a3c2d87028ec3de4e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ADAM12 SLIT3 TENM2

1.69e-05194123b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM12 SLIT3 CORIN

1.69e-05194123240d122dcb9dd1ab2867503ad85869853adcacae
ToppCellMesenchymal_cells-Stromal_fibro.|World / Lineage and Cell class

TM4SF1 TENM2 SPRY2

1.71e-0519512369723b06c2a5c2aaf4d10874b11bca7f06822bdc
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF CORIN

1.74e-051961237d5eaed189aa6116f3799be010139fb675ec65e0
ToppCellFibroblasts-DKK3+_Fibroblasts|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

ADAM12 TM4SF1 SLIT3

1.74e-0519612324d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF CORIN

1.74e-05196123dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCellNon-neuronal-Postmitotic-Endothelial|World / Primary Cells by Cluster

ADAM12 TM4SF1 VWF

1.82e-05199123b9763ac9857a60db6f1f104fe1e9ea2266cf931b
ToppCellNon-neuronal-Postmitotic-Endothelial-Endothelial-24|World / Primary Cells by Cluster

ADAM12 TM4SF1 VWF

1.82e-051991230b4edf3e359749827ef978a77b5267ddde732d71
ToppCellNon-neuronal-Postmitotic-Endothelial-Endothelial|World / Primary Cells by Cluster

ADAM12 TM4SF1 VWF

1.82e-051991239e01eee126247a0696c71b019f855a8a41a0ede3
ToppCellILEUM-inflamed-(8)_Fibroblast-(8)_Fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TM4SF1 SLIT3 SPRY2

1.82e-05199123615f20bf136dfef53b072667cf0e4df6a1017e05
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE-P1-P1_1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

FCGBP CORIN

1.51e-04691223da27f504e82277fa4a8fb67d60fc26dee0a414f
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocyte.Tnr.Ctps_(Ctps)|Thalamus / BrainAtlas - Mouse McCarroll V32

FCGBP CORIN

1.70e-04731220ea6106a85b31d037c9aa16e1ad6a9bcb5b2eda9
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr|Thalamus / BrainAtlas - Mouse McCarroll V32

FCGBP CORIN

1.70e-0473122f2361804ed2e052efc1236d8abfa39ab7cb68dd8
ToppCellTCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-1|TCGA-Brain / Sample_Type by Project: Shred V9

ADAM19 SPRY2

2.93e-049612214cad3fae85e41b9f629b8a81a433b652276930c
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocye.Tnr.Pdgfa_(Pdgfa)|Striatum / BrainAtlas - Mouse McCarroll V32

FCGBP CORIN

3.06e-049812226250ea4171a0557a67505839cf79d3fe4d9d41a
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr|Striatum / BrainAtlas - Mouse McCarroll V32

FCGBP CORIN

3.06e-049812242875d16ae9fcbaf988cd71be82568f2f862f2dd
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2|Striatum / BrainAtlas - Mouse McCarroll V32

FCGBP CORIN

3.06e-04981227a62a77ca83153dacff4d02d6e32104227d0980d
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Cytl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TM4SF1 VWF

3.44e-041041225d9cd14e53a2f1060e528abf6c0694be9d72c356
ToppCellControl-CD8+_T_activated|World / Disease group and Cell class

TCTN1 FCGBP

4.50e-0411912283c3e2bb71b947facbfbef635550901f33c8c26a
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF

4.50e-04119122c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Cytl1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TM4SF1 VWF

5.12e-04127122eee8e4a83f7de46807440d202d46eee7dd722001
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 SPRY2

6.22e-041401227ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 SPRY2

6.22e-041401221a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCellprimary_visual_cortex|World / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLIT3 TENM2

6.31e-04141122605d7b28e99c943f64b4095855a6f9f70e92cb09
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1|Striatum / BrainAtlas - Mouse McCarroll V32

FCGBP CORIN

6.57e-041441229d6133558728fa148050eb4f0be33756d71310b0
ToppCellSevere-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

VWF SPRY2

6.67e-04145122a24cad86509208bc7267b02ef1d1b0a25a2a7043
ToppCellControl-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

OTOGL SPRY2

6.76e-04146122fcd8548b42275758d7d77ad2651afe7ad0e5ea2a
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ADAM19 SLIT3

6.85e-04147122c5913cc351577e54536dd239a33e5f7a5cb79672
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM12 SLIT3

6.94e-04148122f85dc34f6a4a15ecffa4fbd5644dea12ce30089b
ToppCellAdult-Mesenchymal-chondrocyte-D122|Adult / Lineage, Cell type, age group and donor

SLIT3 TENM2

6.94e-0414812281a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM12 SLIT3

6.94e-041481224b1fdf90c585f89cee1cf521db4e3fafc9d74d9a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM12 SLIT3

6.94e-0414812255826b7e9f79ab78a93abd4fc662bc37aa121471
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SLIT3 TENM2

7.22e-0415112232d35906f4b2bd46b173e87f2dec972eb5da87b3
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Trm_Th1/Th17|blood / Manually curated celltypes from each tissue

TM4SF1 ADAM19

7.42e-04153122d09bc7322b59f613d66673359ee6af1aea99ce87
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

TM4SF1 VWF

7.51e-04154122928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOGL SPRY2

7.51e-041541225ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCellfacs-Marrow-KLS-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 SPRY2

7.51e-0415412237765512dfae557b9f6eb30a29463b93682a4404
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 SPRY2

7.61e-04155122c58a5fb8d853f12204e961d633e83452eb12a659
ToppCellfacs-Marrow-KLS-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 SPRY2

7.61e-041551229cb8c42c2e451b2d4dcd7154a4b1bfd21bbb7ea8
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 SPRY2

7.61e-041551227a16df1a40c7255c24dfb9a921b62871554c7b6d
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TM4SF1 VWF

7.61e-041551228e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 SPRY2

7.61e-04155122f51a12556ca0a3416a6cf0687f908fb4e752fb2f
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF

7.71e-041561221c2920f4356789a9c11d5ea1eaafb18a50b19ed7
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF

7.71e-041561220695ac0f02d059ecf813d61d3c9d4c76d1d85834
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell-1|TCGA-Thryoid / Sample_Type by Project: Shred V9

ADAM12 CORIN

7.71e-0415612245a05c7a45a3ec8551818ab67f18b3b9553934c1
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF

7.71e-04156122a45fbe02cd03bd4a097f21368bc1179779ba0db8
ToppCellControl-Myeloid-DC_Langerhans|Control / Disease state, Lineage and Cell class

ADAM19 FCGBP

7.71e-0415612258f371722d21005a9be2e67844ec2e5fec6e31e5
ToppCellfacs-Marrow-T-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOGL SPRY2

7.80e-04157122ed9c9feefc06c9536c03bedbc3397a2ee492a78e
ToppCellfacs-Marrow-T-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOGL SPRY2

7.80e-04157122fddcb24776b9f86e000208bae54541b15b2adefd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLIT3 SPRY2

7.90e-041581221635a85fc73c544028418087f36d28957dd4f458
ToppCellControl-Myeloid-DC_Langerhans|World / Disease state, Lineage and Cell class

ADAM19 FCGBP

7.90e-04158122ec425ec7b8e3c527b4bbe57908d84528b9747796
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLIT3 SPRY2

7.90e-0415812280841dadfa53bcde36a3e486408a095f78e772eb
ToppCellCOPD-Myeloid-DC_Langerhans|COPD / Disease state, Lineage and Cell class

ADAM19 FCGBP

7.90e-0415812271af1319eec34bf7bc9361ec9ef720c280ce97d1
ToppCellPosterior_cortex|World / BrainAtlas - Mouse McCarroll V32

ADAM12 TENM2

8.00e-0415912218e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCellControl-Myeloid-DC_Langerhans|Myeloid / Disease state, Lineage and Cell class

ADAM19 FCGBP

8.10e-04160122174775fb5cc7b478c6cd04f7c565738648ec2fc3
ToppCellCOPD-Myeloid-DC_Langerhans|World / Disease state, Lineage and Cell class

ADAM19 FCGBP

8.10e-041601221b73a14ad6546d9f2812c19081278a79260abeae
ToppCell10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-naive_B_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADAM19 VWF

8.10e-04160122bfbac5ed3273b4430314c6c25cdc1bf0c42b27a1
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TCTN1 ADAM12

8.10e-04160122778faada072e3abfa76a9a06fd4885fb63de7902
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_endothelial_cell_-_unspecif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TM4SF1 VWF

8.20e-041611222a721b6228045adb2dfbcd4990d371f961dc5dc2
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_12|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FCGBP SPRY2

8.20e-041611221d446f5ba57d84949823a35cbedaee8f448fe40f
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM19 CORIN

8.20e-04161122140b3c7077947c541cff54f6754e2df968345f4d
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_12|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FCGBP SPRY2

8.20e-041611221670108afc0af90861eb80a84e59995571c0da1b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM12 SLIT3

8.20e-04161122a7e09cf2ca6cd70d40d08440fe9c5ab9befa1b79
ToppCellfacs-Heart-LA-24m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF SLIT3

8.20e-04161122248487415a0601d57ef2a6692e22a61368d0b9c8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAM12 ADAM19

8.20e-04161122580153e131247e6ec12a1a920f050a0a763e7e87
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TM4SF1 VWF

8.20e-04161122a60ef3f390f56bb05b687b17986fe6382f69f260
ToppCelldroplet-Heart-nan-24m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TM4SF1 VWF

8.20e-04161122eb546d5065ac506405d240f9a1f55f2122d0c368
ToppCellChildren_(3_yrs)-Immune-dendritic_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAM12 ADAM19

8.20e-04161122cd41abb7ae659d3d314281783a0aaad562b26037
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM12 SLIT3

8.20e-0416112208920a716f6ec62538e361211455a30ad726d7be
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM12 SLIT3

8.20e-041611221b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell-Endo|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TM4SF1 VWF

8.31e-041621220bdb1e5ba33e162bec1acb28256c1405a7658ee5
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM12 SPRY2

8.31e-0416212266069146e2666d13c594bd76247893354a697c5d
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM19 CORIN

8.31e-0416212216f9fbcaa0093ffc5a2a5e32db6040e2cb519d47
ToppCellprimary_visual_cortex-Non-neuronal-endothelial_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TM4SF1 VWF

8.31e-041621225799a602ef8d83925907e8e34532428be7330228
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BRPF1 TM4SF1

8.41e-041631221feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TM4SF1 FCGBP

8.41e-04163122f6847f47a8856c0d4136c1af317432d45eccfde9
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TM4SF1 FCGBP

8.41e-04163122a1fbefe53523a9879a4d4b493071059798b5f917
ComputationalPlacenta genes.

TM4SF1 ADAM19 FCGBP VWF

8.80e-04463114MODULE_38
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

TM4SF1 SPRY2

1.14e-0350112GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_9
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

TM4SF1 VWF

1.14e-0350112GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_ENDO_3
ComputationalIntermediate filaments.

TM4SF1 TENM2

2.54e-0375112MODULE_154
ComputationalGenes in the cancer module 297.

TM4SF1 TENM2

2.88e-0380112MODULE_297
ComputationalIntermediate filaments and keratins.

TM4SF1 TENM2

2.88e-0380112MODULE_357
DrugNifuroxazide [965-52-6]; Up 200; 14.6uM; MCF7; HT_HG-U133A

TM4SF1 ADAM19 SPRY2

1.25e-041931234835_UP
DrugH-7 dihydrochloride; Up 200; 100uM; MCF7; HT_HG-U133A

ADAM12 TM4SF1 ADAM19

1.27e-041941235936_UP
DrugPNU-0251126 [267429-19-6]; Down 200; 10uM; MCF7; HT_HG-U133A

TCTN1 TM4SF1 ADAM19

1.31e-041961234711_DN
DrugEnoxacin [74011-58-8]; Up 200; 12.4uM; MCF7; HT_HG-U133A

ADAM12 TM4SF1 SPRY2

1.31e-041961235251_UP
Drug0225151-0000 [351320-15-5]; Up 200; 10uM; PC3; HT_HG-U133A

ADAM12 TM4SF1 ADAM19

1.35e-041981236426_UP
DrugN-phenylanthranilic acid; Up 200; 10uM; MCF7; HG-U133A

ADAM12 SLIT3 SPRY2

1.35e-04198123317_UP
Drugchlorpropamide; Down 200; 100uM; MCF7; HG-U133A

TCTN1 ADAM12 SLIT3

1.39e-04200123141_DN
DrugAmbroxol hydrochloride [23828-92-4]; Down 200; 9.6uM; MCF7; HT_HG-U133A

TCTN1 ADAM19 SPRY2

1.39e-042001233238_DN
Drugwortmannin; Up 200; 0.01uM; SKMEL5; HG-U133A

TCTN1 VWF SLIT3

1.39e-04200123506_UP
Diseaseresponse to hydrochlorothiazide, fasting blood glucose measurement

ADAM12 OTOGL

1.30e-0446112EFO_0004465, EFO_0005202
DiseaseFEV/FEC ratio

ADAM12 ADAM19 FCGBP SPRY2

7.79e-041228114EFO_0004713
DiseaseParoxysmal atrial fibrillation

VWF SLIT3

1.48e-03156112C0235480
DiseasePersistent atrial fibrillation

VWF SLIT3

1.48e-03156112C2585653
Diseasefamilial atrial fibrillation

VWF SLIT3

1.48e-03156112C3468561
DiseaseAtrial Fibrillation

VWF SLIT3

1.56e-03160112C0004238
Diseaseamino acid measurement

ADAM12 VWF SLIT3

1.74e-03678113EFO_0005134
Diseasesusceptibility to childhood ear infection measurement

ADAM12 TENM2

1.77e-03171112EFO_0007904
Diseaseceramide measurement

ADAM19 CORIN

3.31e-03235112EFO_0010222
Diseasepsoriasis

ADAM19 SLIT3

4.44e-03273112EFO_0000676
DiseaseCleft palate, cleft lip

TENM2 SPRY2

4.63e-03279112EFO_0003959, HP_0000175

Protein segments in the cluster

PeptideGeneStartEntry
DCGEEEECNNPCCNA

ADAM19

431

Q9H013
EECDCGEPEECMNRC

ADAM12

436

O43184
DYLCEDGCQNNCPAC

FCGBP

646

Q9Y6R7
PQCQDGCAEGCQCDS

FCGBP

1556

Q9Y6R7
CGDLSDEQNCDCNPT

CORIN

331

Q9Y5Q5
CSDDCAEGCNCPEGK

OTOGL

771

Q3ZCN5
HEDTCNCNLGGDCEC

OTOGL

1161

Q3ZCN5
DCLDPDCCLQSACQN

TENM2

861

Q9NT68
NDDEDNCADNPCSCS

SPRY2

231

O43597
DEDAVCCICNDGECQ

BRPF1

271

P55201
QRCEINPDDCEDNDC

SLIT3

991

O75094
DEECNEACLEGCFCP

VWF

676

P04275
QCDINCCCDPDCSSV

TCTN1

86

Q2MV58
EQDDCCGCCGHENCG

TM4SF1

71

P30408