Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	P-type divalent copper transporter activity	ATP7A ATP7B	4.54e-05	2	135	2	GO:0043682
GeneOntologyMolecularFunction	P-type monovalent copper transporter activity	ATP7A ATP7B	4.54e-05	2	135	2	GO:0140581
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	CAD CDC42BPA HK3 TRIO ADCK1 ROR2 RBKS SIK3 HIPK3 NEK4 CCNH PASK MTOR FGFR1 MARK2	9.20e-05	709	135	15	GO:0016773
GeneOntologyMolecularFunction	cytoskeletal protein binding	MAPK8IP1 MAP9 HIP1 KIF1A SPATA32 PDLIM5 SPTBN5 VILL TRIM32 STARD9 TLN2 ABCG2 LIMCH1 CTNNA1 FHDC1 EML1 MARK2 DCP1A KLHL17	1.52e-04	1099	135	19	GO:0008092
GeneOntologyMolecularFunction	kinase activity	CAD CDC42BPA HK3 TRIO ADCK1 ROR2 RBKS SIK3 HIPK3 NEK4 CCNH PASK MTOR FGFR1 MARK2	2.08e-04	764	135	15	GO:0016301
GeneOntologyMolecularFunction	protein kinase activity	CAD CDC42BPA TRIO ADCK1 ROR2 SIK3 HIPK3 NEK4 CCNH PASK MTOR FGFR1 MARK2	2.19e-04	600	135	13	GO:0004672
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC5A7 SLC28A3 SLC1A1 SLC28A2 SLC4A5	2.23e-04	81	135	5	GO:0015370
GeneOntologyMolecularFunction	nucleoside:sodium symporter activity	SLC28A3 SLC28A2	2.70e-04	4	135	2	GO:0005415
GeneOntologyMolecularFunction	nucleobase:monoatomic cation symporter activity	SLC28A3 SLC28A2	2.70e-04	4	135	2	GO:0015391
GeneOntologyMolecularFunction	pyrimidine- and adenosine-specific:sodium symporter activity	SLC28A3 SLC28A2	2.70e-04	4	135	2	GO:0015389
GeneOntologyMolecularFunction	uridine transmembrane transporter activity	SLC28A3 SLC28A2	6.69e-04	6	135	2	GO:0015213
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	CDC42BPA TRIO ADCK1 SIK3 HIPK3 NEK4 CCNH PASK MTOR MARK2	9.19e-04	446	135	10	GO:0004674
GeneOntologyMolecularFunction	pyrimidine nucleobase transmembrane transporter activity	SLC28A3 SLC28A2	9.32e-04	7	135	2	GO:0005350
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC5A7 SLC28A3 SLC1A1 SLC28A2 CACNA1G SLC4A5	1.09e-03	171	135	6	GO:0015081
GeneOntologyMolecularFunction	pyrimidine nucleoside transmembrane transporter activity	SLC28A3 SLC28A2	1.24e-03	8	135	2	GO:0015214
GeneOntologyMolecularFunction	copper ion transmembrane transporter activity	ATP7A ATP7B	1.24e-03	8	135	2	GO:0005375
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC5A7 SLC28A3 SLC1A1 SLC28A2 SLC4A5	1.29e-03	119	135	5	GO:0015294
GeneOntologyMolecularFunction	enzyme regulator activity	MAPK8IP1 COL6A3 RIN3 TRIO SIPA1L3 CAST RAPGEF1 PSMD2 IRS1 CCNH PSME4 CST5 MARK2 HERC1 BSN MMP16 SERPINA9 RASAL2 TNS3 DCP1A	1.36e-03	1418	135	20	GO:0030234
GeneOntologyMolecularFunction	actin binding	HIP1 SPATA32 PDLIM5 SPTBN5 VILL TLN2 LIMCH1 CTNNA1 FHDC1 KLHL17	1.57e-03	479	135	10	GO:0003779
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CAD CDC42BPA HK3 TRIO ADCK1 ROR2 RBKS SIK3 HIPK3 NEK4 CCNH PASK MTOR FGFR1 MARK2	1.71e-03	938	135	15	GO:0016772
GeneOntologyMolecularFunction	purine nucleobase transmembrane transporter activity	SLC28A3 SLC28A2	1.97e-03	10	135	2	GO:0005345
GeneOntologyMolecularFunction	nucleoside transmembrane transporter activity	SLC28A3 SLC28A2	1.97e-03	10	135	2	GO:0005337
GeneOntologyMolecularFunction	nucleobase transmembrane transporter activity	SLC28A3 SLC28A2	2.40e-03	11	135	2	GO:0015205
GeneOntologyBiologicalProcess	neuron development	NR2E3 ATP7A KIF1A TRIO SZT2 ROR2 ARX RAPGEF1 TENM2 PDLIM5 IL1RAPL1 RNF220 TRIM32 MTOR AP5Z1 BARHL2 CNTN3 FGFR1 CTNNA1 MARK2 HERC1 SEPTIN7 TNR SNX1	2.89e-05	1463	136	24	GO:0048666
GeneOntologyBiologicalProcess	neuron projection development	ATP7A KIF1A TRIO SZT2 ROR2 ARX RAPGEF1 TENM2 PDLIM5 IL1RAPL1 TRIM32 MTOR AP5Z1 BARHL2 CNTN3 FGFR1 CTNNA1 MARK2 HERC1 SEPTIN7 TNR SNX1	3.45e-05	1285	136	22	GO:0031175
GeneOntologyBiologicalProcess	purine nucleobase transport	SLC28A3 SLC28A2 SLC23A3	5.91e-05	12	136	3	GO:0006863
GeneOntologyBiologicalProcess	xenobiotic transport	ATP7B ABCB5 SLC28A3 SLC28A2 ABCG2	6.46e-05	64	136	5	GO:0042908
GeneOntologyBiologicalProcess	nucleobase transport	SLC28A3 SLC28A2 SLC23A3	7.64e-05	13	136	3	GO:0015851
GeneOntologyCellularComponent	postsynapse	HIP1 ATP7A KIF1A TRIO RNF19A ROR2 CAST SLC1A1 TENM2 PDLIM5 IL1RAPL1 RNF220 MTOR FGFR1 MARK2 SEPTIN7 BSN LNX1 SNX1 KLHL17	1.20e-05	1018	138	20	GO:0098794
GeneOntologyCellularComponent	extrinsic component of membrane	TRIO PLEKHA4 TENM2 RYR2 CTNNA1 BSN GNG10 SNX1 COQ7	2.27e-05	230	138	9	GO:0019898
GeneOntologyCellularComponent	actin cytoskeleton	HIP1 CDC42BPA SIPA1L3 PDLIM5 SPTBN5 VILL TLN2 LIMCH1 CTNNA1 FHDC1 MARK2 SEPTIN7 TNS3 KLHL17	2.85e-05	576	138	14	GO:0015629
GeneOntologyCellularComponent	dendrite	MAPK8IP1 RIN3 ATP7A KIF1A ROR2 SLC5A7 SLC1A1 TENM2 IL1RAPL1 MTOR CACNA1G MARK2 BSN SNX1 DCP1A KLHL17	1.75e-04	858	138	16	GO:0030425
GeneOntologyCellularComponent	dendritic tree	MAPK8IP1 RIN3 ATP7A KIF1A ROR2 SLC5A7 SLC1A1 TENM2 IL1RAPL1 MTOR CACNA1G MARK2 BSN SNX1 DCP1A KLHL17	1.80e-04	860	138	16	GO:0097447
GeneOntologyCellularComponent	brush border membrane	ATP7A SLC28A3 SLC28A2 ABCG2 SLC27A4	2.24e-04	83	138	5	GO:0031526
GeneOntologyCellularComponent	somatodendritic compartment	MAPK8IP1 RIN3 CAD ATP7A KIF1A ROR2 SLC5A7 SLC1A1 TENM2 IL1RAPL1 MTOR CST5 CACNA1G MARK2 SEPTIN7 BSN SNX1 DCP1A KLHL17	4.60e-04	1228	138	19	GO:0036477
GeneOntologyCellularComponent	neuron to neuron synapse	ATP7A RNF19A CAST SLC1A1 PDLIM5 IL1RAPL1 BSN LNX1 TNR SNX1 KLHL17	7.15e-04	523	138	11	GO:0098984
GeneOntologyCellularComponent	hippocampal mossy fiber to CA3 synapse	RNF19A BSN LNX1 TNR	1.01e-03	67	138	4	GO:0098686
GeneOntologyCellularComponent	glutamatergic synapse	HIP1 TRIO RNF19A ROR2 TENM2 IL1RAPL1 RNF220 MTOR FGFR1 MARK2 SEPTIN7 BSN TNR KLHL17	1.03e-03	817	138	14	GO:0098978
GeneOntologyCellularComponent	actomyosin	CDC42BPA SIPA1L3 PDLIM5 LIMCH1 SEPTIN7	1.08e-03	117	138	5	GO:0042641
GeneOntologyCellularComponent	neuronal cell body	MAPK8IP1 RIN3 CAD ATP7A KIF1A ROR2 SLC5A7 SLC1A1 MTOR CST5 CACNA1G SEPTIN7 BSN KLHL17	1.27e-03	835	138	14	GO:0043025
MousePheno	abnormal muscle physiology	COL6A3 ATP7B NACA ARX PERM1 RBKS IRS1 PDLIM5 RYR2 PASK LIPE TRIM32 MTOR ASXL3 FGFR1 LIMCH1 EML1 BSN CNOT3 BAIAP2L2 TNS3	8.01e-06	954	106	21	MP:0002106
MousePheno	abnormal kidney copper level	ATP7A ATP7B	5.70e-05	2	106	2	MP:0010242
MousePheno	increased kidney copper level	ATP7A ATP7B	5.70e-05	2	106	2	MP:0010243
MousePheno	increased brain copper level	ATP7A ATP7B	5.70e-05	2	106	2	MP:0011214
MousePheno	abnormal bone mineralization	ROR2 NACA GPRC6A IRS1 SIK3 CST5 CNOT3 MPI	6.93e-05	181	106	8	MP:0002896
Domain	PH_dom-like	MAPK8IP1 CDC42BPA KIF1A TRIO PLEKHA4 IRS1 SPTBN5 OSBPL5 TLN2 FRMPD3 RASAL2 TNS3 DCP1A	1.13e-05	426	133	13	IPR011993
Domain	-	MAPK8IP1 CDC42BPA KIF1A TRIO PLEKHA4 IRS1 SPTBN5 OSBPL5 TLN2 RASAL2 TNS3 DCP1A	2.36e-05	391	133	12	2.30.29.30
Domain	P-typ_ATPase_IB	ATP7A ATP7B	5.03e-05	2	133	2	IPR027256
Domain	HMA_Cu_ion-bd	ATP7A ATP7B	5.03e-05	2	133	2	IPR006122
Domain	C_nuclsd_transpt	SLC28A3 SLC28A2	1.50e-04	3	133	2	IPR008276
Domain	CNT_C_dom	SLC28A3 SLC28A2	1.50e-04	3	133	2	IPR011657
Domain	C_nuclsd_transpt_met_bac	SLC28A3 SLC28A2	1.50e-04	3	133	2	IPR018270
Domain	Gate_dom	SLC28A3 SLC28A2	1.50e-04	3	133	2	IPR011642
Domain	Nucleos_tra2_N	SLC28A3 SLC28A2	1.50e-04	3	133	2	PF01773
Domain	Nucleos_tra2_C	SLC28A3 SLC28A2	1.50e-04	3	133	2	PF07662
Domain	Gate	SLC28A3 SLC28A2	1.50e-04	3	133	2	PF07670
Domain	CNT_N_dom	SLC28A3 SLC28A2	1.50e-04	3	133	2	IPR002668
Domain	Heavy-metal-associated_CS	ATP7A ATP7B	1.50e-04	3	133	2	IPR017969
Domain	ILWEQ_dom	HIP1 TLN2	2.99e-04	4	133	2	IPR002558
Domain	ILWEQ	HIP1 TLN2	2.99e-04	4	133	2	SM00307
Domain	HMA	ATP7A ATP7B	2.99e-04	4	133	2	PF00403
Domain	ILWEQ	HIP1 TLN2	2.99e-04	4	133	2	PD011820
Domain	-	HIP1 TLN2	2.99e-04	4	133	2	1.20.1410.10
Domain	I_LWEQ	HIP1 TLN2	2.99e-04	4	133	2	PF01608
Domain	I_LWEQ	HIP1 TLN2	2.99e-04	4	133	2	PS50945
Domain	HMA_2	ATP7A ATP7B	2.99e-04	4	133	2	PS50846
Domain	HMA_1	ATP7A ATP7B	2.99e-04	4	133	2	PS01047
Domain	PH	CDC42BPA KIF1A TRIO PLEKHA4 IRS1 SPTBN5 OSBPL5 RASAL2	8.59e-04	278	133	8	SM00233
Domain	PH_DOMAIN	CDC42BPA KIF1A TRIO PLEKHA4 IRS1 SPTBN5 OSBPL5 RASAL2	8.79e-04	279	133	8	PS50003
Domain	PH_domain	CDC42BPA KIF1A TRIO PLEKHA4 IRS1 SPTBN5 OSBPL5 RASAL2	8.99e-04	280	133	8	IPR001849
Domain	Vinculin/catenin	TLN2 CTNNA1	1.03e-03	7	133	2	IPR006077
Domain	HMA_dom	ATP7A ATP7B	1.03e-03	7	133	2	IPR006121
Domain	PH	CDC42BPA KIF1A TRIO PLEKHA4 IRS1 SPTBN5 OSBPL5	1.28e-03	229	133	7	PF00169
Domain	Glyco_hydro_47	EDEM3 USF3	1.37e-03	8	133	2	IPR001382
Domain	PROTEIN_KINASE_ATP	CDC42BPA TRIO ADCK1 ROR2 SIK3 HIPK3 NEK4 PASK FGFR1 MARK2	1.67e-03	459	133	10	PS00107
Domain	Kinase-like_dom	CDC42BPA TRIO ADCK1 ROR2 SIK3 HIPK3 NEK4 PASK MTOR FGFR1 MARK2	1.73e-03	542	133	11	IPR011009
Domain	Patatin	PNPLA6 PNPLA3	1.75e-03	9	133	2	PF01734
Domain	PNPLA	PNPLA6 PNPLA3	1.75e-03	9	133	2	PS51635
Domain	DUF3699	TASOR2 GARIN4	1.75e-03	9	133	2	IPR022168
Domain	Patatin/PLipase_A2-rel	PNPLA6 PNPLA3	1.75e-03	9	133	2	IPR002641
Domain	DUF3699	TASOR2 GARIN4	1.75e-03	9	133	2	PF12480
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	RNF19A RNF19B PSMD2 TRIM39 RNF220 PSME4 TRIM32 HERC1 LNX1 LRRC41	5.09e-05	299	100	10	MM15711
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	RNF19A RNF19B PSMD2 TRIM39 RNF220 PSME4 TRIM32 HERC1 LNX1 LRRC41	6.53e-05	308	100	10	M1070
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAPK8IP1 CAD TRIO TBL1Y SIPA1L3 ZNF318 SIK3 TENM2 HIRA FAM171A1 MTOR TLN2 LIMCH1 CTNNA1 EML1 FRMPD3 SEPTIN7 BSN TNR RASAL2	1.61e-09	963	138	20	28671696
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TFEB RIN3 HIP1 MRPL21 CDC42BPA TRIO SZT2 SIPA1L3 RAPGEF1 IRS1 HIRA ZNF503 PNPLA6 PSME4 MTOR OSBPL5 TLN2 FGFR1 HERC1 KLHL17	1.62e-08	1105	138	20	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PDPR CDC42BPA SZT2 NACA POGZ SIK3 PASK PSME4 TECPR2 AP5Z1 OSBPL5 CACNA1G BSN	2.11e-07	529	138	13	14621295
Pubmed	MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.	IRS1 MTOR CTNNA1	2.44e-07	4	138	3	14579029
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TFEB CDC42BPA TRIO SIPA1L3 ROR2 IRS1 SIK3 NEK4 FAM171A1 MTOR STARD9 LIMCH1 MARK2 RASAL2 TNS3 DCP1A	3.49e-07	861	138	16	36931259
Pubmed	Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.	TENM2 SLC28A2 ABCG2	2.11e-06	7	138	3	22229870
Pubmed	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.	CDC42BPA SZT2 POGZ TNR RASAL2	2.97e-06	56	138	5	9455484
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MAPK8IP1 KIF1A TRIO SIPA1L3 PSMD2 NCKAP5 POGZ PDLIM5 CRNKL1 RNF220 TRIM32 TLN2 CTNNA1 SEPTIN7 LNX1 CNOT3 SNX1 RASAL2	3.57e-06	1285	138	18	35914814
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	MAP9 ATP7B ZNF318 SIK3 ZNF503 EDEM3 TRIM32 MTOR LIMCH1 MARK2 SLC27A4 LRRC41 DCP1A	1.04e-05	754	138	13	33060197
Pubmed	Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy.	ATP7A ATP7B	1.56e-05	2	138	2	29394468
Pubmed	Expression of the Menkes gene homologue in mouse tissues lack of effect of copper on the mRNA levels.	ATP7A ATP7B	1.56e-05	2	138	2	8082762
Pubmed	Solution structures of the actuator domain of ATP7A and ATP7B, the Menkes and Wilson disease proteins.	ATP7A ATP7B	1.56e-05	2	138	2	19645496
Pubmed	Differential intracellular localisation of the Menkes and Wilson copper transporting ATPases in the third trimester human placenta.	ATP7A ATP7B	1.56e-05	2	138	2	21115196
Pubmed	Abnormal Cholesterol Metabolism and Lysosomal Dysfunction Induce Age-Related Hearing Loss by Inhibiting mTORC1-TFEB-Dependent Autophagy.	TFEB MTOR	1.56e-05	2	138	2	38139347
Pubmed	Mechanisms of charge transfer in human copper ATPases ATP7A and ATP7B.	ATP7A ATP7B	1.56e-05	2	138	2	28164426
Pubmed	Biochemical basis of regulation of human copper-transporting ATPases.	ATP7A ATP7B	1.56e-05	2	138	2	17562324
Pubmed	Genes regulating copper metabolism.	ATP7A ATP7B	1.56e-05	2	138	2	9823011
Pubmed	mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.	IRS1 MTOR	1.56e-05	2	138	2	23607966
Pubmed	Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes.	ATP7A ATP7B	1.56e-05	2	138	2	17717039
Pubmed	Genetic polymorphisms of copper- and platinum drug-efflux transporters ATP7A and ATP7B in Japanese cancer patients.	ATP7A ATP7B	1.56e-05	2	138	2	20045993
Pubmed	Regulation of the apico-basolateral trafficking polarity of the homologous copper-ATPases ATP7A and ATP7B.	ATP7A ATP7B	1.56e-05	2	138	2	38032054
Pubmed	Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.	IRS1 MTOR	1.56e-05	2	138	2	23400783
Pubmed	Molecular features of copper binding proteins involved in copper homeostasis.	ATP7A ATP7B	1.56e-05	2	138	2	27896900
Pubmed	Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation.	TFEB MTOR	1.56e-05	2	138	2	27268034
Pubmed	ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis.	TFEB ABCG2	1.56e-05	2	138	2	38181789
Pubmed	Regulation of the glutamate transporter EAAT3 by mammalian target of rapamycin mTOR.	SLC1A1 MTOR	1.56e-05	2	138	2	22483750
Pubmed	Pharmacogenetic predictors of severe peripheral neuropathy in colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy: a GEMCAD group study.	CCNH ABCG2	1.56e-05	2	138	2	24351404
Pubmed	A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.	TFEB MTOR	1.56e-05	2	138	2	27172265
Pubmed	Giant Cellular Vacuoles Induced by Rare Earth Oxide Nanoparticles are Abnormally Enlarged Endo/Lysosomes and Promote mTOR-Dependent TFEB Nucleus Translocation.	TFEB MTOR	1.56e-05	2	138	2	27593892
Pubmed	Changes in Expression and Function of Placental and Intestinal P-gp and BCRP Transporters during Pregnancy.	ABCB5 ABCG2	1.56e-05	2	138	2	37685897
Pubmed	mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma.	MTOR FGFR1	1.56e-05	2	138	2	24925055
Pubmed	Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A.	ATP7A ATP7B	1.56e-05	2	138	2	28271598
Pubmed	[Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases].	ATP7A ATP7B	1.56e-05	2	138	2	21117320
Pubmed	[From gene to disease: copper-transporting P ATPases alteration].	ATP7A ATP7B	1.56e-05	2	138	2	19046832
Pubmed	Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.	IRS1 MTOR	1.56e-05	2	138	2	15604215
Pubmed	Expression in mouse kidney of membrane copper transporters Atp7a and Atp7b.	ATP7A ATP7B	1.56e-05	2	138	2	12372948
Pubmed	Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells.	ATP7A ATP7B	1.56e-05	2	138	2	18565219
Pubmed	Copper transporting P-type ATPases and human disease.	ATP7A ATP7B	1.56e-05	2	138	2	12539960
Pubmed	Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2).	IRS1 MTOR	1.56e-05	2	138	2	23863152
Pubmed	MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.	TFEB MTOR	1.56e-05	2	138	2	22576015
Pubmed	Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells.	ATP7A ATP7B	1.56e-05	2	138	2	17109627
Pubmed	Quantitative relationship between mutated amino-acid sequence of human copper-transporting ATPases and their related diseases.	ATP7A ATP7B	1.56e-05	2	138	2	18688737
Pubmed	Expression and localization of menkes and Wilson copper transporting ATPases in human placenta.	ATP7A ATP7B	1.56e-05	2	138	2	15135234
Pubmed	Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters.	ATP7A ATP7B	1.56e-05	2	138	2	9215673
Pubmed	Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins.	ATP7A ATP7B	1.56e-05	2	138	2	18000748
Pubmed	Menkes disease: recent advances and new insights into copper metabolism.	ATP7A ATP7B	1.56e-05	2	138	2	8732640
Pubmed	Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis.	ATP7A ATP7B	1.56e-05	2	138	2	17531189
Pubmed	Intracellular targeting of copper-transporting ATPase ATP7A in a normal and Atp7b-/- kidney.	ATP7A ATP7B	1.56e-05	2	138	2	17928409
Pubmed	Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling.	MTOR OSBPL5	1.56e-05	2	138	2	29358326
Pubmed	TFEB Regulates ATP7B Expression to Promote Platinum Chemoresistance in Human Ovarian Cancer Cells.	TFEB ATP7B	1.56e-05	2	138	2	35053335
Pubmed	mTOR-dependent phosphorylation controls TFEB nuclear export.	TFEB MTOR	1.56e-05	2	138	2	30120233
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDC42BPA KIF1A TRIO SIPA1L3 ROR2 CAST SLC1A1 TASOR2 HIPK3 ZBTB46 USF3 PNPLA6 TECPR2 OSBPL5 LIMCH1 MMP16 SLC4A5 LRRC41	2.60e-05	1489	138	18	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	HIP1 CAD CDC42BPA KIF1A TBL1Y SIPA1L3 NACA ZNF318 HIRA CCNH CRNKL1 PNPLA6 TRIM32 LIMCH1 TAF5L MARK2 HEATR5B CNOT3	2.79e-05	1497	138	18	31527615
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ATP7A ATP7B CDC42BPA KIF1A SLC1A1 FAM171A1 HEATR5B SNX1 RASAL2 SLC27A4	3.53e-05	504	138	10	34432599
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	ABCB5 MAMLD1 PSMD2 COG8 LIPE PSME4 CTNNA1 MARK2	4.63e-05	322	138	8	26514267
Pubmed	FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor-Positive (HR+) Breast Cancer.	MTOR FGFR1	4.68e-05	3	138	2	31371343
Pubmed	MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism.	MUC16 MTOR	4.68e-05	3	138	2	26046375
Pubmed	Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3.	SLC28A3 SLC28A2	4.68e-05	3	138	2	17453413
Pubmed	The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.	TFEB MTOR	4.68e-05	3	138	2	22692423
Pubmed	A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells.	HIP1 SNX1	4.68e-05	3	138	2	29284659
Pubmed	Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells.	IRS1 MTOR	4.68e-05	3	138	2	17721885
Pubmed	Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.	ATP7A ATP7B	4.68e-05	3	138	2	28737129
Pubmed	Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases.	SLC28A3 SLC28A2	4.68e-05	3	138	2	17696452
Pubmed	ATP7A and ATP7B copper transporters have distinct functions in the regulation of neuronal dopamine-β-hydroxylase.	ATP7A ATP7B	4.68e-05	3	138	2	30341172
Pubmed	RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.	CAST RYR2	4.68e-05	3	138	2	15044459
Pubmed	Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection.	SLC28A3 SLC28A2	4.68e-05	3	138	2	23195617
Pubmed	The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum.	ATP7A ATP7B	4.68e-05	3	138	2	15634671
Pubmed	Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis.	ATP7A ATP7B	4.68e-05	3	138	2	10557326
Pubmed	De novo missense variants in RRAGC lead to a fatal mTORopathy of early childhood.	TFEB MTOR	4.68e-05	3	138	2	37057673
Pubmed	BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.	MTOR BAIAP2L2	4.68e-05	3	138	2	32570120
Pubmed	FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling.	IRS1 FGFR1	4.68e-05	3	138	2	33007330
Pubmed	Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.	ATP7A ATP7B	4.68e-05	3	138	2	20566629
Pubmed	Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p.	ATP7A ATP7B	4.68e-05	3	138	2	10497213
Pubmed	Characterization of deoxyribonucleoside transport mediated by concentrative nucleoside transporters.	SLC28A3 SLC28A2	4.68e-05	3	138	2	33910126
Pubmed	A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.	IRS1 MTOR	4.68e-05	3	138	2	11287630
Pubmed	PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1.	PASK MTOR	4.68e-05	3	138	2	24445950
Pubmed	Phosphatidylinositol 3'-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase.	IRS1 PASK	4.68e-05	3	138	2	9761740
Pubmed	Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases.	ATP7A ATP7B	4.68e-05	3	138	2	16884690
Pubmed	Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.	IRS1 MTOR	4.68e-05	3	138	2	16099428
Pubmed	ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR.	MTOR ABCG2	4.68e-05	3	138	2	38981367
Pubmed	Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance.	IRS1 MTOR	4.68e-05	3	138	2	22457523
Pubmed	Intestinal expression of metal transporters in Wilson's disease.	ATP7A ATP7B	4.68e-05	3	138	2	23963605
Pubmed	IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance.	IRS1 MTOR	4.68e-05	3	138	2	24333417
Pubmed	Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.	ATP7A ATP7B	4.68e-05	3	138	2	21242307
Pubmed	FGFR antagonist induces protective autophagy in FGFR1-amplified breast cancer cell.	MTOR FGFR1	4.68e-05	3	138	2	26993162
Pubmed	SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the Occurrence of Colorectal Cancer.	SLC1A1 CNTN3	4.68e-05	3	138	2	32566650
Pubmed	Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes.	IRS1 GKAP1	4.68e-05	3	138	2	25586176
Pubmed	Copper chaperone Atox1 interacts with the metal-binding domain of Wilson's disease protein in cisplatin detoxification.	ATP7A ATP7B	4.68e-05	3	138	2	23751120
Pubmed	Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance.	SLC28A3 SLC28A2	4.68e-05	3	138	2	28385889
Pubmed	Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.	IRS1 MTOR	4.68e-05	3	138	2	15001544
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	MAPK8IP1 CAD CDC42BPA TRIO ADCK1 NACA PSMD2 TENM2 RYR2 TRAP1 TLN2 SEPTIN7 BSN CNOT3 SNX1	4.96e-05	1139	138	15	36417873
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	MAPK8IP1 MAP9 CAD TRIO SIPA1L3 PSMD2 PDLIM5 PNPLA6 GKAP1 TLN2 LIMCH1 CTNNA1 MARK2 SEPTIN7 BSN TNR RASAL2	5.51e-05	1431	138	17	37142655
Pubmed	Establishment and Dysfunction of the Blood-Brain Barrier.	SLC1A1 SLC28A2 ABCG2 SLC27A4	5.54e-05	52	138	4	26590417
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TRIO RNF19A TRAP1 AP5Z1 SLC49A4 CTNNA1 SLC4A5 TNS3	5.74e-05	332	138	8	37433992
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	CDC42BPA CTNNA1 MARK2 SEPTIN7 SNX1	6.72e-05	106	138	5	38891874
Pubmed	La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).	CAD NACA PSMD2 MTOR DCP1A	8.01e-05	110	138	5	25940091
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	CAD NACA CAST PSMD2 TRAP1 CTNNA1	9.17e-05	182	138	6	30711629
Pubmed	[Role of PTEN protein in multidrug resistance of prostate cancer cells].	MTOR ABCG2	9.33e-05	4	138	2	18702307
Pubmed	Genomic organization of the mottled gene, the mouse homologue of the human Menkes disease gene.	ATP7A ATP7B	9.33e-05	4	138	2	8921375
Pubmed	Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7.	LIPE COQ7	9.33e-05	4	138	2	8660658
Interaction	PARD3 interactions	CDC42BPA TRIO SIPA1L3 ROR2 PLEKHA4 FAM171A1 FGFR1 CTNNA1 MARK2 SEPTIN7 RASAL2	5.04e-06	298	134	11	int:PARD3
Interaction	DIRAS3 interactions	HIP1 ATP7A CDC42BPA ROR2 RNF19B PSMD2 MARK2 HERC1 SEPTIN7 RASAL2	1.03e-05	262	134	10	int:DIRAS3
Interaction	YWHAH interactions	TFEB RIN3 CDC42BPA TRIO SIPA1L3 ROR2 PLEKHA4 PSMD2 IRS1 SIK3 FAM171A1 TRIM32 MTOR STARD9 OSBPL5 LIMCH1 MARK2 HERC1 RASAL2 TNS3 DCP1A	1.23e-05	1102	134	21	int:YWHAH
Interaction	YWHAB interactions	TFEB RIN3 CDC42BPA SIPA1L3 ROR2 PLEKHA4 IRS1 SIK3 PDLIM5 NEK4 FAM171A1 TRIM32 MTOR STARD9 FGFR1 MARK2 LNX1 RASAL2 TNS3 DCP1A	1.23e-05	1014	134	20	int:YWHAB
Interaction	ZYX interactions	SIPA1L3 PLEKHA4 PDLIM5 HIPK3 NEK4 TLN2 FGFR1 POC5 LIMCH1 CTNNA1 DCP1A	1.28e-05	329	134	11	int:ZYX
Interaction	BAG2 interactions	TFEB PLEKHA4 ZNF318 PDLIM5 HIRA ZNF503 NEK4 NPHS2 TRIM32 AP5Z1 FGFR1 POC5 CNOT3 SNX1 RASAL2	1.71e-05	622	134	15	int:BAG2
Interaction	GSK3B interactions	CAD TRIO SIPA1L3 ROR2 NACA CAST PLEKHA4 PSMD2 IRS1 PASK RNF220 TRAP1 MTOR CTNNA1 MARK2 RASAL2 TNS3 DCP1A	1.81e-05	868	134	18	int:GSK3B
Interaction	EPB41L4A interactions	CDC42BPA ROR2 FAM171A1 FGFR1 CTNNA1 MARK2 RASAL2	4.23e-05	140	134	7	int:EPB41L4A
Interaction	C11orf52 interactions	ATP7A CDC42BPA TRIO SIPA1L3 ROR2 FAM171A1 CTNNA1 MARK2 SEPTIN7 RASAL2	4.47e-05	311	134	10	int:C11orf52
Interaction	SNTB1 interactions	ROR2 PLEKHA4 FGFR1 MARK2 TNS3	6.22e-05	63	134	5	int:SNTB1
GeneFamily	ATPase copper transporting	ATP7A ATP7B	2.18e-05	2	85	2	1212
GeneFamily	Solute carriers	SLC5A7 SLC28A3 SLC1A1 SLC49A4 SLC28A2 SLC4A5 SLC27A4 SLC23A3	5.37e-04	395	85	8	752
GeneFamily	Patatin like phospholipase domain containing	PNPLA6 PNPLA3	9.59e-04	10	85	2	466
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	TRIO ROR2 IL1RAPL1 CNTN3 FGFR1	9.73e-04	161	85	5	593
GeneFamily	Ring finger proteins	RNF19A RNF19B TRIM39 RNF220 TRIM32 LNX1	1.88e-03	275	85	6	58
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	KIF1A PLEKHA4 IRS1 OSBPL5 RASAL2	2.87e-03	206	85	5	682
GeneFamily	CD molecules\|Mucins	MUC16 MUC13	4.33e-03	21	85	2	648
GeneFamily	Lipases\|Arylacetamide deacetylase family	LIPE PNPLA3	4.75e-03	22	85	2	464
GeneFamily	PDZ domain containing	SIPA1L3 PDLIM5 FRMPD3 LNX1	5.74e-03	152	85	4	1220
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 SLC1A1 LIPE SLC28A2 ABCG2 LIMCH1 EML1 LNX1	1.18e-07	185	138	8	c3105978d971da7d0fad1a717ee29afee5ed6357
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 SLC1A1 LIPE SLC28A2 ABCG2 LIMCH1 EML1 LNX1	1.18e-07	185	138	8	4cfef50aeed5b3000ce5e864a41c13740b8267b1
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 SLC1A1 LIPE SLC28A2 ABCG2 LIMCH1 EML1 LNX1	1.18e-07	185	138	8	09256c6f42f59b7eb89160b2ea706172a5b743be
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	NCKAP5 SIK3 TENM2 PDLIM5 RYR2 IL1RAPL1 PSME4 ABCG2	1.45e-07	190	138	8	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 PLEKHA4 RYR2 GARIN4 CACNA1G GNG10 SLC4A5	1.31e-06	176	138	7	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 PLEKHA4 RYR2 GARIN4 CACNA1G GNG10 SLC4A5	1.31e-06	176	138	7	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP7B TRIO SLC5A7 NCKAP5 IRS1 PNPLA3 TNR	1.58e-06	181	138	7	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP7B TRIO SLC5A7 NCKAP5 IRS1 PNPLA3 TNR	1.58e-06	181	138	7	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP7B TRIO SLC5A7 NCKAP5 IRS1 PNPLA3 TNR	1.58e-06	181	138	7	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	Fetal_29-31_weeks\|World / Lineage, Cell type, age group and donor	COL6A3 ROR2 RYR2 FAM171A1 ASXL3 CNTN3 MMP16	2.96e-06	199	138	7	5b9d355795dd03a22f0961dfd143425c367a4654
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA4 RBKS NPHS2 TECPR2 CACNA1G FHDC1	1.07e-05	160	138	6	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA4 RBKS NPHS2 TECPR2 CACNA1G FHDC1	1.07e-05	160	138	6	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	RNF19B PERM1 ZNF503 ZBTB46 TNR TNS3	1.52e-05	170	138	6	97df5ffb328196c46568975d2d97722bcc753bf5
ToppCell	facs-Heart-RV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 ROR2 PASK FGFR1 FHDC1 SERPINA9	1.52e-05	170	138	6	d7c9a604311974ff87ece43a0f8725a234d262f7
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	HIP1 ABCB5 PERM1 STARD9 NPAP1 CACNA1G	1.62e-05	172	138	6	980e8b9e1ceeb0dec9eb9ef95c139e5ffe99b6e4
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 ROR2 PASK FGFR1 FHDC1 SERPINA9	1.84e-05	176	138	6	c0a084f7a8645262d61971f094689e02bf15b113
ToppCell	facs-Heart-RV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 ROR2 PASK FGFR1 FHDC1 SERPINA9	1.84e-05	176	138	6	cccf9201f6e2da7524b911a5961d3b227edab222
ToppCell	3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HLF MAMLD1 TM6SF1 FGFR1 ABCG2 LIMCH1	2.23e-05	182	138	6	d996ceb77c83591df4cef144ca72862f31d9777f
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.23e-05	182	138	6	8a8b08ac4bb3cba3541dbe234e088703842285b9
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175\|Adult / Lineage, Cell type, age group and donor	IL1RAPL1 ZBTB46 STARD9 EML1 LNX1 TNR	2.23e-05	182	138	6	8b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.23e-05	182	138	6	a05e5978ef5f7fac7eeb2ba1c0103ea90d5e9136
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.23e-05	182	138	6	831b5ce46b41efe01c4db6016c2f43148611373d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.23e-05	182	138	6	3cc61f5f7ad4a81eba3daf65e122880b5af3adc0
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.23e-05	182	138	6	5d909e4b5f662905bf1be9c686bbddc3e87d2be9
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.23e-05	182	138	6	e36766309c4d96a90d213ce37d3acef1029a3fdc
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.44e-05	185	138	6	efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.44e-05	185	138	6	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.44e-05	185	138	6	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 FGFR1 TNR TNS3	2.44e-05	185	138	6	fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCell	droplet-Bladder-nan-24m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIP1 PERM1 LIPE SLC28A2 ABCG2 LIMCH1	2.44e-05	185	138	6	90caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAMLD1 RAPGEF1 TM6SF1 FAM171A1 TLN2 MMP16	2.52e-05	186	138	6	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	Control-Endothelial-Endothelial-Vein\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RIN3 TM6SF1 TLN2 LIMCH1 MMP16 TNR	2.52e-05	186	138	6	92092f11ecce22c14f244e42c499af0822977e6f
ToppCell	Control-Fibroblasts-Other_FB\|Control / group, cell type (main and fine annotations)	COL6A3 ROR2 TENM2 RYR2 TLN2 MMP16	2.59e-05	187	138	6	bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	NCKAP5 TENM2 PDLIM5 RYR2 IL1RAPL1 PSME4	2.75e-05	189	138	6	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF1 SLC1A1 LIPE SLC28A2 ABCG2 LNX1	2.84e-05	190	138	6	38a815abf0ac5cac6071737cadc54a514f62d37d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF1 SLC1A1 LIPE SLC28A2 ABCG2 LNX1	2.84e-05	190	138	6	bb1476b44dd49e1dd52a636a91c4600b6d4fbe2e
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP9 ROR2 PLEKHA4 TENM2 EML1 SLC23A3	2.84e-05	190	138	6	8a53f4d3c9aca45b5826f53f7dcdfb8bc8280acb
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF1 SLC1A1 LIPE SLC28A2 ABCG2 LNX1	2.84e-05	190	138	6	d180205c70b5ca9bc5a01a2e6cb42fcebc7f630d
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	NCKAP5 TENM2 PDLIM5 RYR2 IL1RAPL1 LIMCH1	2.84e-05	190	138	6	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	facs-Heart-LA-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 RAPGEF1 SLC1A1 SLC28A2 LIMCH1 LNX1	2.92e-05	191	138	6	a15f0fb4bd7dd77ef5f931b6fc9d68697deec1d1
ToppCell	facs-Heart-LA-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 RAPGEF1 SLC1A1 SLC28A2 LIMCH1 LNX1	2.92e-05	191	138	6	827be47d3574c6c5b021c6f1c1670834344f10cb
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Endothelial-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF1 SLC1A1 LIPE ABCG2 EML1 LNX1	3.01e-05	192	138	6	8f20d3511dcb44445592b17d005a53da0052ae56
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Endothelial-endothelial_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF1 SLC1A1 LIPE ABCG2 EML1 LNX1	3.01e-05	192	138	6	0986b7900021efe2a4df84a935e7c9a0af1b0e57
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Endothelial\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF1 SLC1A1 LIPE ABCG2 EML1 LNX1	3.01e-05	192	138	6	b28d294e42b303d1db6060231d84d7b9e4d9fccf
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A3 ROR2 MAMLD1 TENM2 RYR2 LIMCH1	3.10e-05	193	138	6	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A3 ROR2 MAMLD1 TENM2 RYR2 LIMCH1	3.10e-05	193	138	6	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	COL6A3 ROR2 RYR2 IL1RAPL1 TLN2 LIMCH1	3.10e-05	193	138	6	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL6A3 ROR2 MAMLD1 RYR2 TLN2 LIMCH1	3.19e-05	194	138	6	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	RAPGEF1 SLC1A1 ZBTB46 EML1 LNX1 RASAL2	3.28e-05	195	138	6	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	ZBTB46 FGFR1 LIMCH1 EML1 HERC1 RASAL2	3.38e-05	196	138	6	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZBTB46 STARD9 ABCG2 LIMCH1 EML1 RASAL2	3.38e-05	196	138	6	ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell	LA-09._Endothelium_I\|LA / Chamber and Cluster_Paper	RAPGEF1 SLC1A1 ZBTB46 EML1 LNX1 RASAL2	3.47e-05	197	138	6	ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZBTB46 LIPE STARD9 OSBPL5 EML1 RASAL2	3.47e-05	197	138	6	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MRPL21 MUC16 PSMD2 GPRC6A STAC2 ASXL3	3.57e-05	198	138	6	dd0465b45b02cb8edf0914d19afb52fcaaeb012c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZBTB46 STARD9 ABCG2 LIMCH1 EML1 RASAL2	3.57e-05	198	138	6	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	Sigmoid-T_cell-Tcm\|T_cell / Region, Cell class and subclass	PLEKHA4 FAM171A1 PASK MTOR SLC4A5 BAIAP2L2	3.67e-05	199	138	6	acdf95f4d58df47690f4ae254245bc618f9ac07e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	RNF19B ARX CAST STARD9 FGFR1 CTNNA1	3.78e-05	200	138	6	98a994692440cb4f505b050276f0c8022c814a21
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	RNF19B ARX CAST STARD9 FGFR1 CTNNA1	3.78e-05	200	138	6	ef222dc4a205d670172dae74990bdb952ac92e5b
ToppCell	RV-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	TENM2 PDLIM5 RYR2 IL1RAPL1 LIMCH1	3.92e-05	122	138	5	1cb1dd03b2aaedbe04f3ed907568c3b7f54767b3
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-4\|TCGA-Cervix / Sample_Type by Project: Shred V9	MAPK8IP1 ATP7B SPATA32 CNTN3 MMP16	4.93e-05	128	138	5	3ca9ae69fb8cb7f8acb7540aa71778bc917da4df
ToppCell	RA-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	PDLIM5 RYR2 IL1RAPL1 STAC2 FAM90A26	6.36e-05	135	138	5	6121b1d30d05b7d476661b932f51191da09dfeeb
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-2\|TCGA-Uvea / Sample_Type by Project: Shred V9	RBKS NEK4 USF3 CNTN3 DCP1A	6.58e-05	136	138	5	b460669c13ed43ff3885acd38ce18f75d693738d
ToppCell	10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3\|bone_marrow / Manually curated celltypes from each tissue	MAP9 ABCB5 HLF ABCG2 TNR	1.22e-04	155	138	5	83430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC5A7 IL1RAPL1 ZBTB46 CNTN3 MMP16	1.46e-04	161	138	5	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ROR2 SPTBN5 SLC23A3 SERTAD1 KLHL17	1.46e-04	161	138	5	0d863d7d369391dd6148e1de6d6f8033dcb8fe0f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 ZBTB46 STARD9 CNTN3 MMP16	1.59e-04	164	138	5	f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAMLD1 TM6SF1 CST5 PNPLA3 ABCG2	1.83e-04	169	138	5	818ab7a6fd1940a22d3bd99fe15f0af888af6b3e
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A3 ARX TENM2 CACNA1G SERPINA9	1.83e-04	169	138	5	335619507857383c3b0b507cdf05d786ed59e585
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAMLD1 TM6SF1 CST5 PNPLA3 ABCG2	1.83e-04	169	138	5	f982f2e0d341fa27229f443ebe5c0e4a9e63bda6
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCDC166 ATP7A RBKS TRIM39 VILL	1.83e-04	169	138	5	813472d429c0b12580b17b440e00a6d8beb7947f
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NCKAP5 SLC1A1 GARIN4 CST5 LIMCH1	1.83e-04	169	138	5	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAMLD1 IL1RAPL1 ZBTB46 CNTN3 MMP16	1.88e-04	170	138	5	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAMLD1 IL1RAPL1 ZBTB46 CNTN3 MMP16	1.88e-04	170	138	5	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 ZBTB46 STARD9 CNTN3 MMP16	1.98e-04	172	138	5	08a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IL1RAPL1 ZBTB46 STARD9 CNTN3 MMP16	1.98e-04	172	138	5	553701349444eb366df3c11f54bb093434f153c6
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF1A ARX ADGRG4 GARIN4 BSN	2.04e-04	173	138	5	07798461d12d04f3dabff03481c999cb07c5af2f
ToppCell	Ionocyte-iono-2\|World / Class top	PDPR ATP7A PRELID3B TM6SF1 LIMCH1	2.04e-04	173	138	5	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZBTB46 LIPE SLC28A2 ABCG2 LNX1	2.09e-04	174	138	5	b1bcd5f4505d2ccef4183fcfbf1de81964b3f9e0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	SIPA1L3 MUC13 IL1RAPL1 LIPE STARD9	2.15e-04	175	138	5	2812ac2ef41d245db544697fb6da1883361c96e8
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC1A1 SLC28A2 ABCG2 CTNNA1 LNX1	2.26e-04	177	138	5	ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC1A1 SLC28A2 ABCG2 CTNNA1 LNX1	2.26e-04	177	138	5	f471f7747d6e8db7546899019af9508f48a14f89
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC1A1 SLC28A2 ABCG2 CTNNA1 LNX1	2.26e-04	177	138	5	cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 ZNF503 FGFR1 BSN MMP16	2.38e-04	179	138	5	dcd0a83f0592ae27f814d064b4791f84c3c86e64
ToppCell	FF-Differ-KC\|World / shred by cell class for mouse tongue	MAP9 ROR2 TENM2 EML1 SLC23A3	2.38e-04	179	138	5	1526a130565a97c291a25a7a988089bffc1515c1
ToppCell	Control-Endothelial_cells-Capillary_endothelial_cells\|Control / group, cell type (main and fine annotations)	IL1RAPL1 EML1 LNX1 TNR RASAL2	2.45e-04	180	138	5	b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCell	E16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRIM39 PASK PNPLA6 OSBPL5 GNG10	2.51e-04	181	138	5	f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCell	IPF-Myeloid-DC_Langerhans\|World / Disease state, Lineage and Cell class	HIP1 SIPA1L3 PRSS56 ZBTB46 CACNA1G	2.57e-04	182	138	5	0e8cfbd8ea196f27a227dbb4d2eb93bc48d27922
ToppCell	droplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZBTB46 LIPE SLC28A2 ABCG2 LIMCH1	2.57e-04	182	138	5	81279877b920b5a1bc991a07d3031d6458700fe3
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NR2E3 TRIO ROR2 IRS1 RYR2	2.57e-04	182	138	5	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ROR2 IL1RAPL1 FAM171A1 NPAP1 LIMCH1	2.64e-04	183	138	5	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	IPF-Lymphoid-ILC_B\|Lymphoid / Disease state, Lineage and Cell class	RIN3 HIP1 ABCB5 ZBTB46 ABCG2	2.64e-04	183	138	5	9b507547e6adf78e46e7f542cd9958224ec5826a
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	TENM2 PDLIM5 RYR2 GARIN4 LIMCH1	2.71e-04	184	138	5	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	IPF-Myeloid-DC_Langerhans\|IPF / Disease state, Lineage and Cell class	HIP1 SIPA1L3 PRSS56 ZBTB46 CACNA1G	2.77e-04	185	138	5	f8ee3cb2aa9ec70f9ce8797be2b155da27ef6464
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 ROR2 HLF IRS1 IL1RAPL1	2.77e-04	185	138	5	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	TENM2 PDLIM5 RYR2 GARIN4 LIMCH1	2.77e-04	185	138	5	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SZT2 ARX IL1RAPL1 CNTN3 TNR	2.84e-04	186	138	5	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 TNR TNS3	2.91e-04	187	138	5	daff7ccd3f1924cf2b34d3aca3eccde245aaf371
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL6A3 ROR2 MAMLD1 PDLIM5 ZBTB46	2.91e-04	187	138	5	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIP1 NCKAP5 PDLIM5 TNR TNS3	2.91e-04	187	138	5	5b7a1edee602e55d3400dc17dbb6b8aaa26defc0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAMLD1 IL1RAPL1 ZBTB46 STARD9 MMP16	2.99e-04	188	138	5	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
Drug	Isopyrin hydrochloride [18342-39-7]; Down 200; 14.2uM; PC3; HT_HG-U133A	CDC42BPA TRIO RNF19A SIPA1L3 POGZ RYR2 MTOR FGFR1 LIMCH1 COQ7	3.17e-07	199	135	10	5879_DN
Drug	0393-0188; Up 200; 10uM; MCF7; HT_HG-U133A	CDC42BPA TRIO SIPA1L3 HLF HIPK3 LIMCH1 CTNNA1 MMP16 CNOT3	2.54e-06	195	135	9	7531_UP
Drug	Ranitidine hydrochloride [66357-59-3]; Up 200; 11.4uM; MCF7; HT_HG-U133A	ZNF280A COL6A3 HIPK3 TECPR2 AP5Z1 LIMCH1 CTNNA1 CNOT3 RASAL2	2.88e-06	198	135	9	5425_UP
Drug	glutamin	NR2E3 HIP1 CAD MAMLD1 PSMD2 GPRC6A SLC1A1 PSME4 MTOR LNX1 TNR SLC4A5	2.01e-05	461	135	12	CID000000738
Drug	Metampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; PC3; HT_HG-U133A	MAP9 SZT2 CAST HIPK3 NPHS2 ABCG2 MMP16 SNX1	2.20e-05	195	135	8	5115_UP
Drug	(-)-depudecin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	ATP7B TRIO SIPA1L3 HIRA PNPLA6 EML1 CNOT3 LRRC41	2.28e-05	196	135	8	982_DN
Drug	Fluphenazine dihydrochloride [146-56-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	HIP1 CDC42BPA SIPA1L3 RNF19B PASK PNPLA6 EML1 COQ7	2.28e-05	196	135	8	7234_DN
Drug	nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A	ZNF280A MAP9 NR2E3 SIPA1L3 RBKS PDLIM5 AP5Z1 CNOT3	2.28e-05	196	135	8	6942_UP
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	TFEB CDC42BPA KIF1A TRIO SZT2 LIPE TNR RASAL2	2.36e-05	197	135	8	7521_UP
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Down 200; 6.2uM; MCF7; HT_HG-U133A	CDC42BPA RNF19A HIPK3 PASK MTOR FGFR1 EML1 MMP16	2.36e-05	197	135	8	2768_DN
Drug	Niflumic acid [4394-00-7]; Down 200; 14.2uM; MCF7; HT_HG-U133A	KIF1A RNF19A SIPA1L3 MAMLD1 TM6SF1 EDEM3 LIMCH1 LRRC41	2.45e-05	198	135	8	5490_DN
Drug	Dubinidine [22964-77-8]; Down 200; 14.6uM; MCF7; HT_HG-U133A	SIPA1L3 RNF19B HIRA PASK PNPLA6 LIMCH1 EML1 MARK2	2.45e-05	198	135	8	3554_DN
Drug	Diflunisal [22494-42-4]; Down 200; 16uM; MCF7; HT_HG-U133A	CDC42BPA ZNF318 PASK PNPLA6 TECPR2 AP5Z1 FGFR1 RASAL2	2.45e-05	198	135	8	4794_DN
Drug	Sulfisoxazole [127-69-5]; Up 200; 15uM; MCF7; HT_HG-U133A	NR2E3 SZT2 ROR2 HLF VILL TECPR2 CACNA1G RASAL2	2.45e-05	198	135	8	5257_UP
Drug	troglitazone; Up 200; 10uM; HL60; HT_HG-U133A	ATP7B TBL1Y IRS1 MUC13 TLN2 LIMCH1 MMP16 RASAL2	2.54e-05	199	135	8	6191_UP
Drug	Sotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A	HIP1 CDC42BPA SZT2 SIPA1L3 RNF19B MMP16 COQ7 LRRC41	2.54e-05	199	135	8	7338_DN
Drug	Tiapride hydrochloride [51012-33-0]; Up 200; 11uM; PC3; HT_HG-U133A	RIN3 CDC42BPA TRIO HLF TLN2 FGFR1 MMP16 COQ7	2.54e-05	199	135	8	7362_UP
Drug	chlorothalonil	NR2E3 HIP1 ROR2 ARX SLC5A7 TRAP1 MTOR	5.24e-05	162	135	7	CID000015910
Drug	Androgen Antagonists	SLC1A1 IL1RAPL1 CNTN3 CACNA1G BSN	8.42e-05	75	135	5	ctd:D000726
Drug	NVP & EFV	CAD IRS1 COG8 MTOR FGFR1 ABCG2	8.55e-05	121	135	6	CID000492400
Drug	tulipanin	RAPGEF1 MTOR	1.04e-04	3	135	2	CID000192918
Drug	enzacamene	SLC1A1 IL1RAPL1 CNTN3 CACNA1G FGFR1 BSN	1.22e-04	129	135	6	ctd:C038939
Drug	carboplatin	MAPK8IP1 ATP7A ATP7B ABCB5 SLC5A7 ABCG2	1.32e-04	131	135	6	CID000038904
Drug	Protriptyline hydrochloride [1225-55-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	TFEB TRIO ZNF318 PDLIM5 RYR2 HIRA FGFR1	1.47e-04	191	135	7	6498_UP
Drug	2-Aminobenzenesulfonamide [3306-62-5]; Down 200; 23.2uM; MCF7; HT_HG-U133A	TRIO HIPK3 PSME4 FGFR1 MARK2 MMP16 CNOT3	1.52e-04	192	135	7	3400_DN
Drug	prazosin hydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A_EA	RNF19A RNF19B HIRA HIPK3 PASK MMP16 CNOT3	1.52e-04	192	135	7	942_DN
Drug	Nitrendipine [39562-70-4]; Up 200; 11uM; HL60; HT_HG-U133A	CDC42BPA SZT2 RBKS PDLIM5 NPHS2 CACNA1G FGFR1	1.52e-04	192	135	7	3087_UP
Drug	racemates	ZNF318 PNPLA6 SLC27A4	1.56e-04	18	135	3	CID000472252
Drug	creatine	HK3 RNF19A SLC1A1 RYR2 CRNKL1 LIPE SLC28A2	1.57e-04	193	135	7	CID000000586
Drug	Amiodarone hydrochloride [19774-82-4]; Up 200; 5.8uM; MCF7; HT_HG-U133A	ZNF280A RNF19A HLF SPTBN5 PNPLA3 MARK2 SNX1	1.57e-04	193	135	7	3296_UP
Drug	Bufexamac [2438-72-4]; Up 200; 18uM; MCF7; HT_HG-U133A	SIPA1L3 RBKS HIPK3 EDEM3 FGFR1 MARK2 COQ7	1.62e-04	194	135	7	7413_UP
Drug	H-89, Dihydrochloride; Up 200; 0.5uM; PC3; HT_HG-U133A	TRIO HIRA EDEM3 PSME4 MTOR EML1 MMP16	1.62e-04	194	135	7	6921_UP
Drug	Oxybutynin chloride [1508-65-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A	SIPA1L3 RNF19B ZNF318 HIRA MTOR TLN2 SNX1	1.62e-04	194	135	7	3168_DN
Drug	Adiphenine hydrochloride [50-42-0]; Up 200; 11.4uM; MCF7; HT_HG-U133A	TRIO SZT2 ZNF318 HIPK3 PNPLA6 AP5Z1 LRRC41	1.67e-04	195	135	7	7037_UP
Drug	Ampyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT_HG-U133A	CDC42BPA RNF19A SIPA1L3 RYR2 HIPK3 FGFR1 MMP16	1.67e-04	195	135	7	6845_DN
Drug	Berberine chloride [633-65-8]; Up 200; 10.8uM; MCF7; HT_HG-U133A	SZT2 RNF19B AP5Z1 LIMCH1 MARK2 RASAL2 LRRC41	1.67e-04	195	135	7	2770_UP
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; PC3; HT_HG-U133A	TFEB CDC42BPA TRIO SPTBN5 AP5Z1 MMP16 RASAL2	1.67e-04	195	135	7	4298_UP
Drug	PNU-0230031 [267429-39-0]; Down 200; 1uM; PC3; HT_HG-U133A	NR2E3 SZT2 SIPA1L3 RBKS HIRA TLN2 FGFR1	1.67e-04	195	135	7	3735_DN
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	MAMLD1 HIRA PASK MTOR MARK2 LRRC41 DCP1A	1.67e-04	195	135	7	1652_DN
Drug	Gentamicine sulfate [1405-41-0]; Up 200; 2.6uM; MCF7; HT_HG-U133A	NR2E3 SIPA1L3 HIRA TLN2 MARK2 MMP16 RASAL2	1.67e-04	195	135	7	7237_UP
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A_EA	ZNF280A HLF PDLIM5 RYR2 PASK LIMCH1 MMP16	1.67e-04	195	135	7	983_UP
Drug	Bufexamac [2438-72-4]; Up 200; 18uM; HL60; HT_HG-U133A	TBL1Y RBKS MUC13 PDLIM5 TECPR2 CACNA1G RASAL2	1.67e-04	195	135	7	2382_UP
Drug	Heliotrine [303-33-3]; Up 200; 12.8uM; MCF7; HT_HG-U133A	ZNF280A NR2E3 TBL1Y SIPA1L3 HLF NPHS2 LIPE	1.67e-04	195	135	7	6035_UP
Drug	Lidoflazine [3416-26-0]; Down 200; 8.2uM; MCF7; HT_HG-U133A	RIN3 CDC42BPA KIF1A SIPA1L3 ZNF318 FGFR1 LRRC41	1.67e-04	195	135	7	3201_DN
Drug	Cefotaxime sodium salt [64485-93-4]; Up 200; 8.4uM; PC3; HT_HG-U133A	ATP7B PASK AP5Z1 TLN2 ABCG2 MMP16 COQ7	1.72e-04	196	135	7	2072_UP
Drug	Isocorydine (+) [475-67-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A	RIN3 RNF19B PDLIM5 HIPK3 FGFR1 MMP16 SNX1	1.72e-04	196	135	7	2780_DN
Drug	Betaxolol hydrochloride [63659-19-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	HIP1 RNF19B HIRA TLN2 LIMCH1 CNOT3 LRRC41	1.72e-04	196	135	7	5669_DN
Drug	Hydrocortisone base [50-23-7]; Down 200; 11uM; PC3; HT_HG-U133A	MAP9 RIN3 TM6SF1 PDLIM5 HIRA ABCG2 MMP16	1.72e-04	196	135	7	6684_DN
Drug	Cefadroxil [50370-12-2]; Up 200; 11uM; MCF7; HT_HG-U133A	RIN3 CDC42BPA SZT2 ZNF318 RYR2 HIPK3 TECPR2	1.72e-04	196	135	7	3259_UP
Drug	Diphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; PC3; HT_HG-U133A	NR2E3 RIN3 SZT2 PDLIM5 HIRA TECPR2 TLN2	1.72e-04	196	135	7	3743_DN
Drug	Chelidonine monohydrate (+) [476-32-4]; Down 200; 10.8uM; PC3; HT_HG-U133A	HIP1 SLC1A1 HIRA NPHS2 AP5Z1 FGFR1 COQ7	1.72e-04	196	135	7	5760_DN
Drug	Miconazole [22916-47-8]; Down 200; 9.6uM; MCF7; HT_HG-U133A	HIP1 SIPA1L3 HIRA PASK TLN2 MMP16 LRRC41	1.78e-04	197	135	7	1477_DN
Drug	Ioversol [87771-40-2]; Down 200; 5uM; HL60; HT_HG-U133A	RIN3 KIF1A SZT2 PDLIM5 HIPK3 PASK PSME4	1.78e-04	197	135	7	3026_DN
Drug	Cefepime hydrochloride [123171-59-5]; Up 200; 7.4uM; MCF7; HT_HG-U133A	TFEB CDC42BPA SZT2 RNF19B HIPK3 CACNA1G CTNNA1	1.78e-04	197	135	7	3581_UP
Drug	Catechin-(+,-) hydrate [7295-85-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A	ZNF280A CDC42BPA TBL1Y HIPK3 AP5Z1 FGFR1 MARK2	1.78e-04	197	135	7	3351_UP
Drug	Demeclocycline hydrochloride [64-73-3]; Down 200; 8uM; HL60; HT_HG-U133A	RIN3 CDC42BPA SIPA1L3 CAST PDLIM5 HIRA LRRC41	1.78e-04	197	135	7	2545_DN
Drug	estradiol, USP; Down 200; 0.1uM; HL60; HT_HG-U133A	RNF19A SIPA1L3 RNF19B CAST PDLIM5 HIRA LRRC41	1.78e-04	197	135	7	1149_DN
Drug	Erythromycin [114-07-8]; Up 200; 5.4uM; PC3; HT_HG-U133A	HIP1 ROR2 RAPGEF1 HIPK3 PASK CST5 TLN2	1.78e-04	197	135	7	6729_UP
Drug	CP-319743 [172078-87-4]; Down 200; 10uM; MCF7; HT_HG-U133A	NR2E3 TRIO PDLIM5 PASK TLN2 FGFR1 LRRC41	1.78e-04	197	135	7	7486_DN
Drug	Ioversol [87771-40-2]; Up 200; 5uM; PC3; HT_HG-U133A	TFEB RIN3 HIPK3 LIPE TLN2 MARK2 MMP16	1.78e-04	197	135	7	6726_UP
Drug	Vancomycin hydrochloride [1404-93-9]; Up 200; 2.6uM; PC3; HT_HG-U133A	TFEB NR2E3 SPTBN5 PASK TLN2 MMP16 RASAL2	1.78e-04	197	135	7	4598_UP
Drug	Baclofen (R,S) [1134-47-0]; Down 200; 18.8uM; PC3; HT_HG-U133A	ZNF318 HIRA PASK AP5Z1 FGFR1 MMP16 SNX1	1.78e-04	197	135	7	6313_DN
Drug	Trioxsalen [3902-71-4]; Down 200; 17.6uM; MCF7; HT_HG-U133A	TRIO RBKS SIK3 MTOR MMP16 SNX1 MPI	1.78e-04	197	135	7	6216_DN
Drug	octylmethoxycinnamate	SLC1A1 IL1RAPL1 CNTN3 CACNA1G FGFR1 BSN	1.83e-04	139	135	6	ctd:C118580
Drug	Nalidixic acid sodium salt hydrate; Up 200; 14.6uM; HL60; HT_HG-U133A	SZT2 SIPA1L3 PDLIM5 HIRA SPTBN5 TECPR2 COQ7	1.83e-04	198	135	7	2336_UP
Drug	Tropine [120-29-6]; Down 200; 28.4uM; PC3; HT_HG-U133A	TFEB ATP7B RYR2 HIRA PASK AP5Z1 MMP16	1.83e-04	198	135	7	5790_DN
Drug	rotenone; Up 200; 1uM; PC3; HT_HG-U133A	RIN3 HIP1 KIF1A TRIO SZT2 RBKS RASAL2	1.83e-04	198	135	7	5948_UP
Drug	Homosalate [118-56-9]; Up 200; 15.2uM; MCF7; HT_HG-U133A	MAP9 COL6A3 TRIO HIRA SPTBN5 FGFR1 MMP16	1.83e-04	198	135	7	3879_UP
Drug	Quinic acid [86-68-0]; Up 200; 19.6uM; MCF7; HT_HG-U133A	NR2E3 RIN3 RNF19B RYR2 EDEM3 COQ7 RASAL2	1.83e-04	198	135	7	6019_UP
Drug	Ungerine nitrate; Down 200; 10.2uM; PC3; HT_HG-U133A	RNF19A PDLIM5 HIRA PSME4 TECPR2 AP5Z1 MMP16	1.83e-04	198	135	7	5816_DN
Drug	Fluocinonide [356-12-7]; Down 200; 8uM; PC3; HT_HG-U133A	RIN3 TRIO RNF19A HIRA PASK FGFR1 TAF5L	1.83e-04	198	135	7	3757_DN
Drug	Hexamethonium dibromide dihydrate [55-97-0]; Down 200; 10uM; MCF7; HT_HG-U133A	KIF1A RNF19B HIRA PASK MTOR EML1 MARK2	1.83e-04	198	135	7	1482_DN
Drug	Phenindione [83-12-5]; Down 200; 18uM; PC3; HT_HG-U133A	RNF19A SIPA1L3 ZNF318 HIRA AP5Z1 LIMCH1 MPI	1.89e-04	199	135	7	7289_DN
Drug	Benzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	TFEB HIP1 RNF19B HLF PDLIM5 SEPTIN7 MMP16	1.89e-04	199	135	7	6056_DN
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; HL60; HT_HG-U133A	TFEB KIF1A RBKS PDLIM5 FGFR1 SEPTIN7 MMP16	1.89e-04	199	135	7	2408_UP
Drug	Xylometazoline hydrochloride [1218-35-5]; Down 200; 14.2uM; MCF7; HT_HG-U133A	RNF19A SIPA1L3 MAMLD1 PDLIM5 TLN2 FGFR1 CNOT3	1.89e-04	199	135	7	7020_DN
Drug	Nifurtimox [23256-30-6]; Up 200; 14uM; PC3; HT_HG-U133A	RIN3 HIP1 TRIO PASK NPHS2 SLC4A5 RASAL2	1.89e-04	199	135	7	6608_UP
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	NR2E3 PDLIM5 MTOR TLN2 SEPTIN7 CNOT3 RASAL2	1.89e-04	199	135	7	3664_DN
Drug	Metaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A	KIF1A TRIO RNF19A PASK PNPLA6 MTOR MPI	1.89e-04	199	135	7	4831_DN
Drug	Harmane hydrochloride [21655-84-5]; Down 200; 18.2uM; MCF7; HT_HG-U133A	HIP1 CDC42BPA KIF1A TRIO SIPA1L3 HIRA LRRC41	1.89e-04	199	135	7	2806_DN
Drug	Thiethylperazine malate [52239-63-1]; Down 200; 6uM; PC3; HT_HG-U133A	RIN3 HIP1 SZT2 PASK NPHS2 TECPR2 ZNF239	1.89e-04	199	135	7	5756_DN
Drug	Sulfamerazine [127-79-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A	SIPA1L3 SPTBN5 NPHS2 TECPR2 FGFR1 MARK2 LRRC41	1.95e-04	200	135	7	4740_UP
Drug	eupatin	ABCB5 ABCG2	2.08e-04	4	135	2	CID005317287
Disease	occipital horn syndrome (implicated_via_orthology)	ATP7A ATP7B	1.96e-05	2	131	2	DOID:0111272 (implicated_via_orthology)
Disease	non-small cell lung carcinoma, disease prognosis measurement	SEPTIN7 TNS3	1.96e-05	2	131	2	EFO_0003060, EFO_0007936
Disease	Cannabis use, age at onset	CAST SLC28A3 RYR2	7.87e-05	19	131	3	EFO_0004847, EFO_0007585
Disease	Autosomal Recessive Hereditary Spastic Paraplegia	PNPLA6 TECPR2	1.17e-04	4	131	2	C0751603
Disease	X-Linked, Spastic Paraplegia, Hereditary	PNPLA6 TECPR2	1.17e-04	4	131	2	C0751605
Disease	Hereditary X-Linked Recessive Spastic Paraplegia	PNPLA6 TECPR2	1.17e-04	4	131	2	C0751604
Disease	metal metabolism disorder (implicated_via_orthology)	ATP7A ATP7B	1.17e-04	4	131	2	DOID:896 (implicated_via_orthology)
Disease	Wilson disease (implicated_via_orthology)	ATP7A ATP7B	1.94e-04	5	131	2	DOID:893 (implicated_via_orthology)
Disease	Hereditary Autosomal Dominant Spastic Paraplegia	PNPLA6 TECPR2	1.94e-04	5	131	2	C0751602
Disease	Menkes disease (implicated_via_orthology)	ATP7A ATP7B	1.94e-04	5	131	2	DOID:1838 (implicated_via_orthology)
Disease	HMSN Type V	PNPLA6 TECPR2	1.94e-04	5	131	2	C4721916
Disease	Cleft palate, cleft lip	CAST TENM2 TLN2 FGFR1 POC5 LIMCH1 MMP16	2.58e-04	279	131	7	EFO_0003959, HP_0000175
Disease	hereditary spastic paraplegia (is_implicated_in)	KIF1A AP5Z1	4.05e-04	7	131	2	DOID:2476 (is_implicated_in)
Disease	pantothenate measurement	CAD TENM2	5.38e-04	8	131	2	EFO_0021034
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	RAPGEF1 FGFR1	5.38e-04	8	131	2	DOID:4783 (biomarker_via_orthology)
Disease	biological sex	CDC42BPA SLC28A3 TENM2 BARHL2 MMP16 TNR	5.84e-04	230	131	6	PATO_0000047
Disease	descending aortic diameter	COL6A3 SIK3 PDLIM5 LNX1	6.48e-04	88	131	4	EFO_0021788
Disease	spinal muscular atrophy (implicated_via_orthology)	ATP7A ATP7B	6.90e-04	9	131	2	DOID:12377 (implicated_via_orthology)
Disease	Major Depressive Disorder	ATP7B HLF SLC5A7 PDLIM5 MTOR FGFR1	7.78e-04	243	131	6	C1269683
Disease	aortic measurement	COL6A3 CAST PDLIM5 RYR2 CNTN3 LNX1	9.20e-04	251	131	6	EFO_0020865
Disease	myeloid white cell count	RIN3 CDC42BPA PSMD2 SIK3 SPATA32 TRAP1 TLN2 PNPLA3 TNR RASAL2 TNS3 SERTAD1	9.80e-04	937	131	12	EFO_0007988
Disease	Unipolar Depression	ATP7B HLF SLC5A7 PDLIM5 MTOR FGFR1	1.08e-03	259	131	6	C0041696
Disease	serum albumin measurement	TFEB RIN3 MAMLD1 SLC28A3 SIK3 ZBTB46 BSN LNX1 SERPINA9	1.34e-03	592	131	9	EFO_0004535
Disease	Squamous cell carcinoma of the head and neck	ATP7B IRS1 ABCG2	1.61e-03	52	131	3	C1168401
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	MTOR ABCG2 CNOT3	1.70e-03	53	131	3	C1961099
Disease	Malformations of Cortical Development	SLC1A1 MTOR	1.72e-03	14	131	2	C1955869
Disease	Spastic Paraplegia, Hereditary	PNPLA6 TECPR2	1.72e-03	14	131	2	C0037773
Disease	Cortical Dysplasia	SLC1A1 MTOR	1.72e-03	14	131	2	C0431380
Disease	vascular dementia (biomarker_via_orthology)	MTOR FGFR1	1.72e-03	14	131	2	DOID:8725 (biomarker_via_orthology)
Disease	Metastatic melanoma	TRIO PASK MTOR	1.80e-03	54	131	3	C0278883
Disease	level of triacylglycerol (56:6) in blood serum	SIK3 PNPLA3	2.25e-03	16	131	2	OBA_2020007
Disease	muscular dystrophy (is_implicated_in)	COL6A3 TRIM32	2.55e-03	17	131	2	DOID:9884 (is_implicated_in)
Disease	Febrile seizure (within the age range of 3 months to 6 years)	HERC1 BSN	2.86e-03	18	131	2	HP_0002373
Disease	ovarian neoplasm	ATP7B MUC16 CCNH MTOR	3.05e-03	134	131	4	C0919267
Disease	cannabis dependence	SLC28A3 TENM2 BARHL2 CNTN3	3.14e-03	135	131	4	EFO_0007191
Disease	sleep measurement	SLC28A3 RYR2 HIPK3 GKAP1	3.14e-03	135	131	4	EFO_0004870
Disease	diacylglycerol 38:3 measurement	PNPLA3 CNOT3	3.18e-03	19	131	2	EFO_0020065
Disease	smoking behaviour measurement	SLC28A3 SLC1A1 TENM2 BARHL2 CNTN3	3.18e-03	222	131	5	EFO_0005671
Disease	Malignant neoplasm of ovary	ATP7B MUC16 CCNH MTOR	3.31e-03	137	131	4	C1140680
Disease	neutrophil count	RIN3 CDC42BPA PSMD2 POGZ SIK3 STAC2 TRAP1 TLN2 PNPLA3 POC5 LNX1 TNR TNS3 SERTAD1	3.39e-03	1382	131	14	EFO_0004833
Disease	end stage renal disease (implicated_via_orthology)	IRS1 MTOR	3.53e-03	20	131	2	DOID:783 (implicated_via_orthology)
Disease	severe acute respiratory syndrome, COVID-19	COL6A3 RIN3 MAMLD1 PSMD2 TENM2 IL1RAPL1 TNR	3.90e-03	447	131	7	EFO_0000694, MONDO_0100096
Disease	neurodegenerative disease (implicated_via_orthology)	PSMD2 SLC1A1 PNPLA6 MARK2	4.05e-03	145	131	4	DOID:1289 (implicated_via_orthology)
Disease	chronic kidney disease	COL6A3 RIN3 SIPA1L3 PSMD2 FAM171A1	4.06e-03	235	131	5	EFO_0003884
Disease	obesity (biomarker_via_orthology)	LIPE MTOR PNPLA3 FGFR1	4.25e-03	147	131	4	DOID:9970 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SESALAMTDISSLAS	ZNF280A	246	P59817
ALGTRASASSFLNMS	ADCK1	451	Q86TW2
AILSSASRAGITMES	CCNH	216	P51946
DGHLLTLMSTRSAST	ADGRG4	616	Q8IZF6
SAAMAASSVSVVLSS	ATP7B	1356	P35670
LSTSPLIMASAAACS	ABCB5	211	Q2M3G0
SSMALAIAAGQSVVS	ABCG2	521	Q9UNQ0
TMRDVLLAATANTSS	CFAP46	2096	Q8IYW2
MASAVLSSVPTTASR	GKAP1	1	Q5VSY0
CAAILREMSPSDSLS	AP5Z1	86	O43299
SADTVRSPADSLSMS	CCDC74A	156	Q96AQ1
TAAARVAASASLSNM	DCP1A	441	Q9NPI6
SMGTTVRAALSCSDS	ASXL3	1386	Q9C0F0
SSLKSMAERAAISSG	CNOT3	541	O75175
AAMAASSVSVVLSSL	ATP7A	1391	Q04656
TALMSSTVAAAAPAA	NR2E3	6	Q9Y5X4
ASSGASVRLTCMLSS	IGLV5-52	31	A0A0A0MRZ9
TPATSLEALTMARRS	RBKS	156	Q9H477
SLSASSSSLTPMGRD	FHDC1	716	Q9C0D6
SSAGLERASVMPLTT	MUC16	2776	Q8WXI7
AVPSAASMTSTRAAS	POC5	431	Q8NA72
SLVDTSVSATSRPRM	PNPLA6	121	Q8IY17
MASRSAGTLLTEFNA	FAM166C	1	A6NJV1
LSAASLEMGNRSLSD	PASK	1276	Q96RG2
ASMSESLSIPASLND	FAM171A1	661	Q5VUB5
NRASSASARLMTSEF	MAP9	366	Q49MG5
LNVFMSGRSRSSSAE	MAPK8IP1	461	Q9UQF2
SSASMSLSREGSVSL	GARIN4	356	Q8IYT1
SLSLADMDNAASISP	EDEM3	846	Q9BZQ6
MRALSLLSVSGSSCS	HERC1	3191	Q15751
SSSAAATVRAMSSVG	BSN	2651	Q9UPA5
LPSSRRSSMGSTAVA	BAIAP2L2	471	Q6UXY1
TVSAISMAAATSTAL	IL1RAPL1	586	Q9NZN1
RNSTSAAEARSMALP	PDPR	26	Q8NCN5
RSSEMSSSKDRPLSA	NEK4	601	P51957
MSLDSSPESAALAVR	PNPLA3	281	Q9NST1
MSSNSTALALVRPSS	CT83	31	Q5H943
MATAATIPSVATATA	COG8	1	Q96MW5
ASESLRMAAEILSGT	NPHS2	301	Q9NP85
SASLRSTGSMSVVSA	RASAL2	891	Q9UJF2
SPEVSAAATISLMTD	LNX1	161	Q8TBB1
MSSGASASALQRLVE	GNG10	1	P50151
LASSVASTRSMPESL	PDLIM5	316	Q96HC4
ASSAAPSVMDLSSRA	HLF	116	Q16534
AEEVSLPRATMAAAS	IRS1	1021	P35568
LPRATMAAASSSSAA	IRS1	1026	P35568
DGSLAMLSTRFDASV	HK3	721	P52790
DRMCSLSSPDSTLST	HIPK3	906	Q9H422
MGSNSEVARLLASSD	MPI	21	P34949
VSSIALSPASLDSMS	GPRC6A	861	Q5T6X5
RSTAADMAASTAAGK	CRNKL1	156	Q9BZJ0
ESSSRTLAPVSTMLA	FCAMR	446	Q8WWV6
LAASSDMSTATLLSS	HEATR5B	1196	Q9P2D3
SPVASMLSRRSSAGV	KLHL17	511	Q6TDP4
SIISGAALMADSSCT	CTNNA1	311	P35221
MLDDVIASGSSASAA	CACNA1G	1571	O43497
ADSSASMNSGVLLVR	FGFR1	431	P11362
ADERATATAIASMLS	SLC49A4	176	Q96SL1
AGLEMSLRAATSSLS	FRMPD3	941	Q5JV73
ASRVPSLVLSSMDSR	CCDC166	331	P0CW27
SLVLSSMDSRVPSLA	CCDC166	336	P0CW27
SSGMTLDNISRAAVD	COQ7	36	Q99807
PARSASSSTINLMVS	COL6A3	3086	P12111
MVAVAGSASAQSRTL	CST5	16	P28325
LLGSMDSTTAAAAAA	BARHL2	321	Q9NY43
MSDQALEALSASLGT	CAST	286	P20810
ALLSSMTSSSNAALG	MAMLD1	386	Q13495
LTMPGSRASTASASA	MARK2	506	Q7KZI7
STMAPLTSASTAAAL	ARX	486	Q96QS3
ASAASSMEVTDRIAS	EML1	26	O00423
KSAATREMGSATSVA	HIRA	416	P54198
SLDTAALSATDMALA	RYR2	2501	Q92736
VSRAKSDMAVSTPAS	PERM1	291	Q5SV97
IPRITSMDARGSTSA	CNTN3	991	Q9P232
AQALLTALMISSSSA	SLC1A1	321	P43005
MSPSSSLSALSSRAA	KIF1A	401	Q12756
LSSLANMASATVRVS	LIPE	551	Q05469
TIARASVLDTSMSAG	LIMCH1	506	Q9UPQ0
MSASSSREPSCRELL	PRSS56	336	P0CW18
LASLSDSLGVSVMAT	RIN3	531	Q8TB24
LSAMLSSTARAAQAP	OSBPL5	836	Q9H0X9
SPELRSTAMDTLSSL	MTOR	1166	P42345
VVALPTASRSTLAMD	HSFX1	336	Q9UBD0
TASRSTLAMDTTGLP	HSFX1	341	Q9UBD0
SAAVMSSADSSILSA	SLC5A7	341	Q9GZV3
DSGLIASASMDNSVR	TAF5L	521	O75529
SPLDMVSSRSSDAAR	SZT2	2136	Q5T011
ATASAASTSVTFREM	TRIM32	311	Q13049
MAETSLLEAGASAAS	TRIM39	1	Q9HCM9
LSTMSPEASKASSRR	TFEB	451	P19484
ASTISSNASKGREAM	PRELID3B	146	Q9Y3B1
SLGAISDNASTRAMA	RNF19B	556	Q6ZMZ0
SDNASTRAMAGSIIS	RNF19B	561	Q6ZMZ0
TTMEATSREAAPAKS	LRRC41	21	Q15345
SALSAVSSMRAQTLE	NCKAP5	1756	O14513
MEGSRPRSSLSLASS	PLEKHA4	1	Q9H4M7
SGSQVDSARMNLASS	PSMD2	361	Q13200
SEEVLAMLSASSTLP	POGZ	1236	Q7Z3K3
TEMSDRGSALASLSP	FAM90A26	171	D6RGX4
EMAATSAAIETATAR	HIP1	786	O00291
LITFASSLAMASSSR	SPATA32	241	Q96LK8
GASAASAASAMASLT	SIPA1L3	371	O60292
SAASAMASLTASRAH	SIPA1L3	376	O60292
ALSSARMSDAVLSQS	SIK3	1241	Q9Y2K2
DSSDRLLAVTMPSVA	TENM2	1956	Q9NT68
TAPSNTSMADRAALL	ROR2	876	Q01974
ASPALMVLASTAEAS	RNF220	21	Q5VTB9
MVLASTAEASRDASI	RNF220	26	Q5VTB9
TASVMSAPASLAAAK	SLC28A3	391	Q9HAS3
TAARLDAVLPMSSSF	STARD9	1261	Q9P2P6
SSDAALSASMASLLE	SERTAD1	106	Q9UHV2
KSTMLRADASSTPSF	TNS3	906	Q68CZ2
RSMSASSGLSARSSA	CDC42BPA	1626	Q5VT25
SAASLSKPAIDTSDM	NPAP1	811	Q9NZP6
ALAAGISMALAASTS	SLC23A3	316	Q6PIS1
GVDASSLISASVMAA	SLC28A2	356	O43868
STSLAMLSLGAHSVT	SERPINA9	76	Q86WD7
SESRTLAAKMAALAS	SPTBN5	1466	Q9NRC6
TSSSASPARDSLMRH	C17orf64	26	Q86WR6
SVLRSAETMQSALAA	MMP16	61	P51512
VSTSLSPRSEMRADD	MUC13	266	Q9H3R2
GAIRDNLSETASTMA	RNF19A	526	Q9NV58
NLSETASTMALAGAS	RNF19A	531	Q9NV58
LAMLGSSEDNTALSR	SNX1	351	Q13596
AVVAPMSRATSGSSL	RAPGEF1	301	Q13905
TSRARALVFGSEMAS	SLC27A4	171	Q6P1M0
RSAAAEERSVNSSTM	SEPTIN7	6	Q16181
ETLAVASASPMAAAA	SOGA3	301	Q5TF21
GTSLALMNRSSFSST	STAC2	211	Q6ZMT1
LDSPRDLMVTASSET	TNR	686	Q92752
DSSMDLISRTRSPAA	SLC4A5	81	Q9BY07
AMSPLLTIANSSASD	USF3	2206	Q68DE3
ATVSETRLRGSSMAS	TECPR2	386	O15040
TRLRGSSMASSVASE	TECPR2	391	O15040
SSMASSVASEPRSRS	TECPR2	396	O15040
MAASSLTVTLGRLAS	MRPL21	1	Q7Z2W9
SSIMLASASFDSTVR	TBL1Y	421	Q9BQ87
LMASAGRSFSTAVTE	PSME4	1581	Q14997
EVSTRTSSSFAAAMA	CAD	1971	P27708
TRTMEVPARASSLNS	VILL	521	O15195
PSSSSLASAAAAAMA	ZNF503	556	Q96F45
SMFDVSRELGSSVAL	TRAP1	351	Q12931
SAARMVAAATSSLCE	TLN2	2396	Q9Y4G6
MLADLALSSATSSTP	TASOR2	536	Q5VWN6
ASSPISRNRDSVMTL	ZNF239	36	Q16600
GFSRILSMLADSTST	ZNF318	506	Q5VUA4
SSSTEALISAVMAGR	ZBTB46	151	Q86UZ6
AVNDMGSASSSASLR	TRIO	2761	O75962
MSASAATGVFVLSLS	TM6SF1	1	Q9BZW5
AETAVLPMSSALSVT	NACA	21	E9PAV3