Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsmall GTPase binding

DENND5B DOCK4 EPS8 IPO8 TNPO2 FMNL3 RANBP17 DIAPH2 DIAPH3

1.24e-043211189GO:0031267
GeneOntologyMolecularFunctionGTPase binding

DENND5B DOCK4 EPS8 IPO8 TNPO2 FMNL3 RANBP17 DIAPH2 DIAPH3

2.90e-043601189GO:0051020
GeneOntologyMolecularFunctioncalcium- and calmodulin-responsive adenylate cyclase activity

ADCY5 ADCY8

3.42e-0451182GO:0008294
GeneOntologyBiologicalProcessnegative regulation of axon guidance

SLIT2 PTPRO

3.19e-0521172GO:1902668
GeneOntologyBiologicalProcessnegative regulation of retinal ganglion cell axon guidance

SLIT2 PTPRO

3.19e-0521172GO:0090260
GeneOntologyCellularComponentFanconi anaemia nuclear complex

FANCM FANCA FANCB

7.22e-05151163GO:0043240
GeneOntologyCellularComponentstereocilium bundle

DOCK4 EPS8 PKHD1L1 ELMOD3 DIAPH3

7.84e-05791165GO:0032421
DomainARM-type_fold

PPP4R1 VPS11 IPO8 TNPO2 SCYL1 HEATR5A UNC45A LYST ITPR1 FMNL3 RANBP17 VAC14 URB1 THADA NF1 DIAPH2 EFR3B PRKDC DIAPH3 HTT

2.10e-1433911520IPR016024
Domain-

PPP4R1 IPO8 TNPO2 SCYL1 HEATR5A UNC45A RANBP17 VAC14 NF1 EFR3B PRKDC HTT

1.24e-08222115121.25.10.10
DomainARM-like

PPP4R1 IPO8 TNPO2 SCYL1 HEATR5A UNC45A RANBP17 VAC14 NF1 EFR3B PRKDC HTT

1.07e-0727011512IPR011989
DomainHEAT_REPEAT

PPP4R1 TNPO2 SCYL1 HEATR5A VAC14 PRKDC HTT

2.43e-07701157PS50077
DomainHEAT

PPP4R1 TNPO2 SCYL1 VAC14 PRKDC HTT

4.75e-07481156PF02985
DomainHEAT

PPP4R1 TNPO2 SCYL1 VAC14 PRKDC HTT

1.49e-06581156IPR000357
DomainDrf_GBD

FMNL3 DIAPH2 DIAPH3

1.86e-0591153PF06371
DomainDrf_FH3

FMNL3 DIAPH2 DIAPH3

1.86e-0591153PF06367
DomainFH3_dom

FMNL3 DIAPH2 DIAPH3

1.86e-0591153IPR010472
DomainGTPase-bd

FMNL3 DIAPH2 DIAPH3

1.86e-0591153IPR010473
DomainDrf_FH3

FMNL3 DIAPH2 DIAPH3

1.86e-0591153SM01139
DomainDrf_GBD

FMNL3 DIAPH2 DIAPH3

1.86e-0591153SM01140
DomainGBD/FH3_dom

FMNL3 DIAPH2 DIAPH3

3.62e-05111153IPR014768
DomainGBD_FH3

FMNL3 DIAPH2 DIAPH3

3.62e-05111153PS51232
DomainFH2

FMNL3 DIAPH2 DIAPH3

9.80e-05151153PS51444
DomainFH2_Formin

FMNL3 DIAPH2 DIAPH3

9.80e-05151153IPR015425
DomainFH2

FMNL3 DIAPH2 DIAPH3

9.80e-05151153PF02181
DomainIBN_N

IPO8 TNPO2 RANBP17

9.80e-05151153PF03810
DomainFH2

FMNL3 DIAPH2 DIAPH3

9.80e-05151153SM00498
DomainDrf_DAD

DIAPH2 DIAPH3

1.12e-0431152PF06345
DomainDrf_DAD

DIAPH2 DIAPH3

1.12e-0431152IPR010465
DomainIBN_N

IPO8 TNPO2 RANBP17

1.20e-04161153SM00913
DomainImportin-beta_N

IPO8 TNPO2 RANBP17

1.45e-04171153IPR001494
DomainRetinoicA-induced_16-like

FHIP1B FHIP1A

2.24e-0441152IPR019384
DomainRAI16-like

FHIP1B FHIP1A

2.24e-0441152PF10257
DomainPBC

PBX2 PBX3

2.24e-0441152PF03792
DomainPBX

PBX2 PBX3

2.24e-0441152IPR005542
DomainPentatricopeptide_repeat

PTCD2 PRKDC HTT

3.68e-04231153IPR002885
Domain3-oxo-5_a-steroid_4-DH_C

TECR TECRL

3.71e-0451152IPR001104
DomainSteroid_dh

TECR TECRL

3.71e-0451152PF02544
DomainS5A_REDUCTASE

TECR TECRL

3.71e-0451152PS50244
DomainAdcy_conserved_dom

ADCY5 ADCY8

5.55e-0461152IPR009398
DomainDUF1053

ADCY5 ADCY8

5.55e-0461152PF06327
DomainCa_chan_IQ

CACNA1B CACNA1S

7.74e-0471152SM01062
DomainCa_chan_IQ

CACNA1B CACNA1S

7.74e-0471152PF08763
DomainVDCC_a1su_IQ

CACNA1B CACNA1S

7.74e-0471152IPR014873
DomainGPHH

CACNA1B CACNA1S

7.74e-0471152PF16905
DomainGPHH_dom

CACNA1B CACNA1S

7.74e-0471152IPR031649
DomainDAD_dom

DIAPH2 DIAPH3

1.03e-0381152IPR014767
DomainAC_N

ADCY5 ADCY8

1.03e-0381152IPR032628
DomainAdcy

ADCY5 ADCY8

1.03e-0381152IPR030672
DomainDAD

DIAPH2 DIAPH3

1.03e-0381152PS51231
DomainAC_N

ADCY5 ADCY8

1.03e-0381152PF16214
DomainVDCCAlpha1

CACNA1B CACNA1S

1.64e-03101152IPR002077
DomainCRAL_TRIO_2

PRUNE2 NF1

2.38e-03121152PF13716
DomainOlfact_rcpt

OR8U1 OR13C5 OR8U8 OR1F1 OR51D1 OR51I2 OR13C2 OR8B12

2.99e-033931158IPR000725
DomainIMPORTIN_B_NT

IPO8 TNPO2

3.26e-03141152PS50166
DomainA/G_cyclase_CS

ADCY5 ADCY8

4.81e-03171152IPR018297
DomainCTCK_1

MUC5B SLIT2

5.39e-03181152PS01185
Domain-

ADCY5 ADCY8

5.39e-031811523.30.70.1230
DomainNucleotide_cyclase

ADCY5 ADCY8

5.39e-03181152IPR029787
DomainIon_trans_dom

CACNA1B CACNA1S ITPR1 TRPM1

5.41e-031141154IPR005821
DomainIon_trans

CACNA1B CACNA1S ITPR1 TRPM1

5.41e-031141154PF00520
DomainGuanylate_cyc

ADCY5 ADCY8

6.00e-03191152PF00211
DomainGUANYLATE_CYCLASE_2

ADCY5 ADCY8

6.00e-03191152PS50125
DomainA/G_cyclase

ADCY5 ADCY8

6.00e-03191152IPR001054
DomainGUANYLATE_CYCLASE_1

ADCY5 ADCY8

6.00e-03191152PS00452
DomainCYCc

ADCY5 ADCY8

6.00e-03191152SM00044
PathwayKEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY

KDM3A ADCY5 ADCY8 SMARCA2 ACTL6B

1.88e-0635845M47969
PathwayPID_FANCONI_PATHWAY

HUS1 FANCM FANCA FANCB

1.72e-0447844M1
PathwayKEGG_MEDICUS_REFERENCE_FANCONI_ANEMIA_PATHWAY

FANCM FANCA FANCB

1.85e-0419843M47853
PathwayWP_RETT_SYNDROME

SYNE2 SMARCA2 ACTL6B HTT

1.87e-0448844M39759
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

COPA BAZ2B ITPR1 NUP205 URB1 MDN1 GLE1 SMARCA2 POLR1B PRKDC

2.68e-073401181029478914
Pubmed

Evidence for subcomplexes in the Fanconi anemia pathway.

FANCM FANCA FANCB

1.32e-067118316720839
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

ITPR1 FANCA NF1 MDN1 DIAPH2 HTT

1.55e-06104118631240132
Pubmed

FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.

FANCM FANCA FANCB

3.15e-069118317396147
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

COPA POLE TECR SCYL1 UNC45A NUP205 FANCA SLIT2 VAC14 URB1 THADA GLE1 DHCR24 PRKDC

3.99e-069421181431073040
Pubmed

Modularized functions of the Fanconi anemia core complex.

FANCM FANCA FANCB

4.49e-0610118324910428
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1B EPS8 ATRX COPA ITPR1 SLIT2 FRY NF1 SMU1 HTT

5.38e-064751181031040226
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

DYM IPO8 COPA TNPO2 TECR RELB UNC45A ITPR1 NUP205 URB1 THADA MDN1 TRAM1 DHCR24 SYNE2 SMU1 PRKDC

7.52e-0614401181730833792
Pubmed

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.

FANCM FANCA FANCB

8.19e-0612118316116422
Pubmed

An immunocompromised murine model of chronic Bartonella infection.

LYST PRKDC

1.14e-052118220395436
Pubmed

N-type Ca2+ channels are affected by full-length mutant huntingtin expression in a mouse model of Huntington's disease.

CACNA1B HTT

1.14e-052118228391067
Pubmed

Cell type-dependent mechanisms for formin-mediated assembly of filopodia.

FMNL3 DIAPH3

1.14e-052118226446836
Pubmed

Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice.

LYST PRKDC

1.14e-05211829234770
Pubmed

Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.

LYST PRKDC

1.14e-052118217392156
Pubmed

Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice.

LYST PRKDC

1.14e-05211828140728
Pubmed

Spontaneous and experimental infections in scid and scid/beige mice.

LYST PRKDC

1.14e-05211828320959
Pubmed

Genetic markers of comorbid depression and alcoholism in women.

ADCY5 ADCY8

1.14e-052118223278386
Pubmed

ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors.

LYST PRKDC

1.14e-052118219249873
Pubmed

Studies of virus-induced myocardial injury in mice: value of the scid mutation on different genetic backgrounds and combined with other mutations.

LYST PRKDC

1.14e-05211828391609
Pubmed

Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes.

LYST PRKDC

1.14e-05211828075241
Pubmed

SCID-bg mice as xenograft recipients.

LYST PRKDC

1.14e-05211829175014
Pubmed

Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa.

LYST PRKDC

1.14e-05211821639480
Pubmed

Translocation of bacteria from the gastrointestinal tract in immunodeficient mice.

LYST PRKDC

1.14e-05211828709573
Pubmed

Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals.

LYST PRKDC

1.14e-05211828962121
Pubmed

Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells.

LYST PRKDC

1.14e-052118223094018
Pubmed

N-type calcium current, Cav2.2, is enhanced in small-diameter sensory neurons isolated from Nf1+/- mice.

CACNA1B NF1

1.14e-052118224755485
Pubmed

Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report.

LYST PRKDC

1.14e-05211828267959
Pubmed

The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model.

LYST PRKDC

1.14e-052118220739949
Pubmed

Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis.

LYST PRKDC

1.14e-05211829673277
Pubmed

Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.

LYST PRKDC

1.14e-05211828418200
Pubmed

Mycobacterium avium subspecies paratuberculosis triggers intestinal pathophysiologic changes in beige/scid mice.

LYST PRKDC

1.14e-052118211924817
Pubmed

Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors.

LYST PRKDC

1.14e-052118210225324
Pubmed

MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.

FANCM FANCA FANCB

1.35e-0514118320347429
Pubmed

Expression of multiple formins in adult tissues and during developmental stages of mouse brain.

FMNL3 DIAPH2 DIAPH3

1.35e-0514118326272686
Pubmed

Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.

FANCM FANCA FANCB

1.68e-0515118317289582
Pubmed

Esophageal Atresia / Tracheoesophageal Fistula Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

FANCM FANCA FANCB

2.06e-0516118320301753
Pubmed

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

FANCM FANCA FANCB

2.06e-0516118327760317
Pubmed

A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.

FANCM FANCA FANCB

2.06e-0516118320347428
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

POLE RELB FHIP1B LYST FANCA STK10 VAC14 URB1 THADA MDN1 DIAPH2 WDR90 PRKDC HTT

2.38e-0511051181435748872
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

HUS1 POLE TECR FANCM FANCA CENPP FANCB MDN1 MORC3

2.55e-05453118929656893
Pubmed

FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.

FANCM FANCA FANCB

2.99e-0518118322343915
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZBTB17 ATRX COPA BAZ2B TECR FANCM FANCA URB1 MDN1 ACTL8 TRAM1 DHCR24 PRSS21 SMU1 PRKDC

3.34e-0512941181530804502
Pubmed

Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex.

SMARCA2 ACTL6B

3.42e-053118212437990
Pubmed

Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis.

ATRX ZNF460

3.42e-053118234738503
Pubmed

The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.

PBX2 PBX3

3.42e-053118215169896
Pubmed

Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice.

LYST PRKDC

3.42e-05311827717446
Pubmed

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia.

TLR9 PRKDC

3.42e-053118226796361
Pubmed

The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.

FANCM FANCA

3.42e-053118216116434
Pubmed

A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b.

PBX2 PBX3

3.42e-053118210679934
Pubmed

Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.

LYST PRKDC

3.42e-053118235167491
Pubmed

Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.

LYST PRKDC

3.42e-053118229242210
Pubmed

CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury.

LYST PRKDC

3.42e-053118223792169
Pubmed

Interactions of the scid or beige mutations with the viable motheaten mutation.

LYST PRKDC

3.42e-05311828781712
Pubmed

The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.

PBX2 PBX3

3.42e-053118211468159
Pubmed

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

PBX2 PBX3

3.42e-053118217942707
Pubmed

POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4.

POLR1D POLR1B

3.42e-053118231649276
Pubmed

Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.

LYST PRKDC

3.42e-05311828806787
Pubmed

Defective killing of Candida albicans hyphae by neutrophils from beige mice.

LYST PRKDC

3.42e-05311827769315
Pubmed

Essential and nonredundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration.

DIAPH2 DIAPH3

3.42e-053118224403606
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

IPO8 TNPO2 TECR VAC14 THADA PRKDC

3.95e-05183118623956138
Pubmed

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.

FANCM FANCA FANCB

4.16e-0520118322705371
Pubmed

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

IPO8 COPA NUP205 DHCR24 PRKDC

4.33e-05113118530352685
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

PRUNE2 SNX3 TECR FHIP1B VAC14 DHCR24 HTT

5.60e-05285118734369648
Pubmed

Fanconi Anemia

FANCM FANCA FANCB

6.42e-0523118320301575
Pubmed

Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway.

FANCM FANCA

6.82e-054118227398742
Pubmed

Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.

LYST PRKDC

6.82e-054118210202929
Pubmed

Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells.

DIAPH2 DIAPH3

6.82e-054118218044991
Pubmed

mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation.

DIAPH2 DIAPH3

6.82e-054118211509578
Pubmed

Treacher Collins Syndrome

POLR1D POLR1B

6.82e-054118220301704
Pubmed

Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis.

DIAPH2 DIAPH3

6.82e-054118224239357
Pubmed

Strain-dependent leakiness of mice with severe combined immune deficiency.

LYST PRKDC

6.82e-05411828473734
Pubmed

Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice.

LYST PRKDC

6.82e-054118211152110
Pubmed

Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.

PTPRH PTPRO

6.82e-054118220398064
Pubmed

EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination.

DIAPH2 DIAPH3

6.82e-054118223890216
Pubmed

Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

PBX2 PBX3

6.82e-054118218723445
Pubmed

Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).

DIAPH2 DIAPH3

6.82e-054118221278336
Pubmed

Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.

ATRX PRKDC

6.82e-054118220150414
Pubmed

PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.

PBX2 PBX3

6.82e-05411821682799
Pubmed

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.

TLR9 PRKDC

6.82e-054118212626561
Pubmed

The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.

LYST PRKDC

6.82e-054118227703030
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

COPA POLE NUP205 URB1 NF1 MDN1 SYNE2 SMU1 SMARCA2 PRKDC

8.05e-056531181022586326
Pubmed

Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin.

PTPRH PTPRO

1.13e-045118228926625
Pubmed

Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium.

LYST PRKDC

1.13e-045118222617213
Pubmed

Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24.

FANCM FANCA

1.13e-045118218174376
Pubmed

Toll-like receptor 9-induced type I IFN protects mice from experimental colitis.

TLR9 PRKDC

1.13e-045118215765149
Pubmed

Transcription factor PBX4 regulates limb development and haematopoiesis in mice.

PBX2 PBX3

1.13e-045118238230761
Pubmed

RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.

DIAPH2 DIAPH3

1.13e-045118223034183
Pubmed

Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.

PBX2 PBX3

1.13e-045118210842069
Pubmed

Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway.

FANCM FANCA

1.13e-045118221975120
Pubmed

IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder.

LYST PRKDC

1.13e-045118210358203
Pubmed

Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis.

PBX2 PBX3

1.13e-045118211335119
Pubmed

HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.

PBX2 PBX3

1.13e-045118210082572
Pubmed

Evidence for at least eight Fanconi anemia genes.

FANCA FANCB

1.13e-04511829382107
Pubmed

Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice.

PRUNE2 DHCR24 ACTL6B

1.30e-0429118321909369
Pubmed

Probing nuclear pore complex architecture with proximity-dependent biotinylation.

UNC45A NUP205 GLE1 PRKDC

1.41e-0477118424927568
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

IPO8 ATRX POLE TECR UNC45A PGD ITPR1 URB1 THADA MDN1 TRAM1 SYNE2 SMU1 EFR3B DIAPH3

1.58e-0414871181533957083
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CCDC14 DOCK4 EPS8 IPO8 HUS1 DIS3L UNC45A FHIP1B NUP205 MORC3 FHIP1A

1.60e-048531181128718761
Pubmed

FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair.

FANCM FANCA

1.70e-046118218285517
Pubmed

EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration.

DIAPH2 DIAPH3

1.70e-046118215311282
Pubmed

T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice.

LYST PRKDC

1.70e-046118217438029
InteractionGPR17 interactions

DYM IPO8 TNPO2 HEATR5A FHIP1B FANCA VAC14 URB1 THADA MDN1 PRKDC DGAT1 HTT

4.94e-0928311013int:GPR17
InteractionC3orf18 interactions

VPS11 DYM TNPO2 THADA NF1 MDN1 PRKDC DIAPH3

2.22e-071151108int:C3orf18
InteractionUNC93B1 interactions

DYM IPO8 COPA TNPO2 TECR TLR9 NUP205 THADA MDN1 TRAM1 DHCR24 PRKDC

2.97e-0641711012int:UNC93B1
InteractionTNFSF13B interactions

DYM IPO8 TNPO2 FHIP1B NF1 MDN1 PRKDC

4.03e-061191107int:TNFSF13B
InteractionTPST2 interactions

DYM IPO8 VAC14 THADA NF1 CSGALNACT2 TRAM1

5.30e-061241107int:TPST2
InteractionGPR182 interactions

DYM IPO8 NUP205 FANCA URB1 THADA MDN1 GLE1 DHCR24 PRKDC DGAT1 HTT

7.23e-0645511012int:GPR182
InteractionOPALIN interactions

DYM IPO8 TNPO2 NUP205 THADA NF1 MDN1 PRKDC

1.94e-052091108int:OPALIN
InteractionFANCE interactions

ENPP1 FANCM FANCA FANCB

2.06e-05301104int:FANCE
InteractionNPTN interactions

DOCK4 IPO8 TNPO2 FANCA RANBP17 VAC14 THADA MDN1 HTT

2.19e-052781109int:NPTN
InteractionCD274 interactions

IPO8 COPA TNPO2 TECR PGD VAC14 THADA NF1 DHCR24 PRKDC

3.47e-0536911010int:CD274
InteractionCD70 interactions

DYM HUS1 TNPO2 NUP205 THADA MDN1 CSGALNACT2

3.54e-051661107int:CD70
InteractionDCPS interactions

COPA BAZ2B ITPR1 NUP205 URB1 MDN1 GLE1 SMARCA2 POLR1B PRKDC

6.01e-0539411010int:DCPS
InteractionCD80 interactions

TNPO2 VAC14 THADA NF1 PRKDC

7.23e-05791105int:CD80
InteractionTACSTD2 interactions

HUS1 TNPO2 URB1 THADA NF1 MDN1

7.61e-051291106int:TACSTD2
InteractionC19orf38 interactions

TNPO2 THADA NF1 PRKDC DIAPH3

1.08e-04861105int:C19orf38
InteractionCOMTD1 interactions

DYM IPO8 TNPO2 NUP205 VAC14 THADA DIAPH3

1.15e-042001107int:COMTD1
InteractionFHDC1 interactions

FMNL3 DIAPH2 DIAPH3

1.22e-04181103int:FHDC1
InteractionHCST interactions

DYM TNPO2 FANCA VAC14 THADA NF1 MDN1

1.34e-042051107int:HCST
InteractionCTDP1 interactions

ITPR1 FANCA NF1 MDN1 DIAPH2 PRKDC HTT

1.42e-042071107int:CTDP1
InteractionFPR1 interactions

DYM IPO8 FANCA URB1 THADA PRKDC

1.56e-041471106int:FPR1
InteractionSCN2B interactions

HUS1 TNPO2 THADA MDN1 DIAPH3

1.73e-04951105int:SCN2B
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

FANCM FANCA FANCB

6.31e-0520713548
GeneFamilyAdenylate cyclases|Deafness associated genes

ADCY5 ADCY8

6.70e-041071253
GeneFamilyX-linked mental retardation|RNA helicases

ATRX FANCM

8.17e-04117121168
GeneFamilyOlfactory receptors, family 8

OR8U1 OR8U8 OR8B12

9.39e-0449713155
GeneFamilyArmadillo repeat containing|Importins

IPO8 TNPO2

2.23e-0318712596
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRH PTPRO

3.04e-0321712813
GeneFamilyOlfactory receptors, family 13

OR13C5 OR13C2

3.65e-0323712162
GeneFamilyWD repeat domain containing

COPA LYST WDR91 SMU1 WDR90

3.68e-03262715362
GeneFamilyCalcium voltage-gated channel subunits

CACNA1B CACNA1S

4.65e-0326712253
GeneFamilyTALE class homeoboxes and pseudogenes

PBX2 PBX3

4.65e-0326712526
GeneFamilyRNA polymerase subunits

POLR1D POLR1B

5.76e-0329712726
GeneFamilyNucleoporins

NUP205 GLE1

6.99e-03327121051
GeneFamilyOlfactory receptors, family 51

OR51D1 OR51I2

1.29e-0244712164
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000

CCDC14 DYM POLE HEATR5A FANCM NUP205 RANBP17 FANCB VAC14 URB1 THADA MDN1 POLR1B PRKDC DIAPH3 MORC3

3.12e-0682210616gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000

DYM POLE HEATR5A NUP205 RANBP17 FANCB URB1 THADA MDN1 MORC3

6.61e-0633310610gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
CoexpressionAtlasdev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

DYM POLE HEATR5A NUP205 RANBP17 FANCB URB1 MDN1 MORC3

7.56e-062661069gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k2_1000
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#4_top-relative-expression-ranked_1000

DYM HEATR5A RANBP17 URB1 THADA MDN1 POLR1B MORC3

3.01e-052431068gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k4_1000
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

DYM POLE CENPP RANBP17 FANCB URB1 MDN1 DIAPH3 MORC3

8.28e-053611069gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k2_1000
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND5B KLF6 SCYL1 NXT2 ITPR1 PTPRO

4.67e-071101176bc1986e5a496a4d25da3445b6f252f81741619f4
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 CFAP73 NOXRED1 CPHXL MDN1 DIAPH3

1.36e-06132117646c80eab16a70da9f363a9fbdf50bccab0b287d7
ToppCellLPS-IL1RA+antiTNF-Unknown|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 CFAP73 NOXRED1 CPHXL MDN1 DIAPH3

1.36e-061321176a022c3c41654166cb106f27dc54fa88e8c40f898
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKG LYST STK10 FRY GVINP1 DIAPH3

3.87e-06158117691d265e95156f16459924d3e4dd11c180e164eee
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B MUC5B PKHD1L1 ADCY8 PAFAH1B3 UNC80

4.16e-061601176c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B MUC5B PKHD1L1 ADCY8 PAFAH1B3 UNC80

4.16e-06160117625c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB46 THADA MDN1 PTPRO PAFAH1B3 MORC3

7.18e-0617611766b4afd2c9268172063fe5832896bea15e862579e
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC14 AASDH CENPP FRY PANK2 PBX3

8.97e-0618311763ef9ac1ae13b6172f9121ab1c129ecaa0fef460f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ADCY5 WDR91 SYNE2 DIAPH3 PBX3

9.84e-061861176f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

PRUNE2 DGKG ADCY5 SLIT2 FRY PRDM6

1.01e-051871176464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ADCY5 WDR91 SYNE2 DIAPH3 PBX3

1.01e-051871176c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell343B-Lymphocytic-ILC-ILC-1|343B / Donor, Lineage, Cell class and subclass (all cells)

DYM HEATR5A NUP205 ZBTB37 HTT CFAP46

1.05e-0518811768f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 DGKG ADCY5 ITPR1 SLIT2 PRDM6

1.14e-0519111767853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell343B-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DYM HEATR5A NUP205 ZBTB37 HTT CFAP46

1.18e-051921176445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCellhuman_hepatoblastoma-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

POLE FANCM FANCA CENPP GSTCD DIAPH3

1.21e-0519311764b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

POLE FANCA CENPP FANCB PRKDC DIAPH3

1.29e-051951176cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

POLE FANCA CENPP FANCB PRKDC DIAPH3

1.33e-051961176df366d76ea55f49e349d622effa57c1535df8400
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

EPS8 ATRX BAZ2B TRAM1 SYNE2 SMARCA2

1.44e-051991176fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

EPS8 ATRX KLF6 UNC45A TRAM1 SYNE2

1.44e-051991176d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRUNE2 ENPP1 NOXRED1 CENPP MDN1

5.42e-05154117516fdafb5c64d2db321554f87129a962d113f1668
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RELB AASDH TECRL RANBP17 OR51D1

5.59e-05155117593f21b09f6f7755991d67886361b1c42a50fbbfc
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

CFAP73 CFAP65 GAS2L2 SYNE2 CFAP46

5.76e-05156117510d191e29b16cae8238e8df6c0ff38882253f34e
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGKG LYST STK10 GVINP1 DIAPH3

6.89e-05162117593bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B TLR9 NF1 PTPRO ELMOD3

9.13e-051721175356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B TLR9 NF1 PTPRO ELMOD3

9.13e-05172117546fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B TLR9 NF1 PTPRO ELMOD3

9.13e-051721175438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1S EPS8 ZBTB46 PTPRO PAFAH1B3

9.39e-051731175f66aebceb3eb389bc5ff6c0b398d6f4e9959a14f
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

PRUNE2 ENPP1 DGKG ADCY5 PRDM6

9.39e-051731175a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B CACNA1S MUC5B PAFAH1B3 SLC23A1

9.64e-0517411753f4277763e312b46ebd4401ea4a2f5d4c850c768
ToppCelldroplet-Lung-nan-21m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B CACNA1S MUC5B PAFAH1B3 SLC23A1

9.64e-051741175fad66d1a8407574b6a835e0bdb824a53afa58650
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PPP4R1 DGKG PTPRO WDR90 DGAT1

1.02e-04176117590f8bb11f339f67f08692a0c33dd420f5cda2861
ToppCellE12.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CACNA1S DGKG TECRL ADCY8 PRDM6

1.05e-0417711755cdf413f82376a95467322b16d10b0d1e7557e2d
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRX LYST GVINP1 SYNE2 DIAPH2

1.07e-04178117501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP73 SLC30A3 ADCY8 CFAP65 CFAP46

1.07e-04178117558857bb8c13e0e1c6d9f5c1258f00fff62063d68
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP73 SLC30A3 ADCY8 CFAP65 CFAP46

1.07e-0417811758b7df6ab8709d9ab9dff97677cc4561aec2745bc
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP73 SLC30A3 ADCY8 CFAP65 CFAP46

1.07e-041781175b0baf5667e3301898b3e45e974b8a8530af6a338
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_4|Classical_Monocyte / Disease condition and Cell class

FANCA ZBTB37 NF1 MDN1 SMU1

1.10e-0417911759d51318ac198a8801bd5c7031ebf2b0c74ffeeb6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FANCA CENPP FANCB PRKDC DIAPH3

1.10e-04179117588d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_4|COVID-19_Convalescent / Disease condition and Cell class

FANCA ZBTB37 NF1 MDN1 SMU1

1.10e-041791175366e4a31db9e80fd1770ac9f1ae148fefeb9f7df
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B CACNA1S ENPP1 PAFAH1B3 ACTL6B

1.16e-04181117597022416d0f5a5ba9c9bd5e70ce95cf4cb19af89
ToppCellRA-13._Vascular_Smooth_Muscle|RA / Chamber and Cluster_Paper

PRUNE2 DGKG ADCY5 ITPR1 FRY

1.22e-041831175818fd886e0188091310825f9145fa53328f2c979
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POLE MUC5B CENPP WDR90 DIAPH3

1.22e-0418311756c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCellwk_08-11-Epithelial-PNS-PCP4+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CACNA1B FRMPD1 FRY PTPRH ACTL6B

1.25e-041841175eac2a9089913f33a961ba11519b53645790f2056
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

POLE MUC5B CENPP WDR90 DIAPH3

1.29e-04185117547c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 ATRX PKHD1L1 LYST SYNE2

1.32e-0418611750ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DGKG ADCY5 ITPR1 SLIT2 PRDM6

1.32e-0418611754780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ADCY5 WDR91 SYNE2 DIAPH3

1.39e-041881175af740fa78542438fdff627ea1f74f4eee43316be
ToppCell343B-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DYM HEATR5A NUP205 ZBTB37 CFAP46

1.42e-041891175c26428871dc3261327d89cacaba6e21e004ff1f3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK4 PPP4R1 RANBP17 DIAPH3 FHIP1A

1.46e-04190117530b50d183d7649146eb1e79b47ba897355f1998a
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

POLE FANCA CENPP DIAPH3 PBX3

1.46e-041901175d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MUC5B HEATR5A PRSS21 GSTCD DIAPH3

1.60e-0419411750e9830ad070c47acaa952400bf2a3ddbff664a2f
ToppCell3'_v3-blood-Lymphocytic_NK-Cycling_NK|blood / Manually curated celltypes from each tissue

POLE FANCA CENPP WDR90 DIAPH3

1.60e-041941175bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|lung / Disease (COVID-19 only), tissue and cell type

PRUNE2 EPS8 DGKG ADCY5 FRY

1.60e-0419411755e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-plasma_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND5B CACNA1S ENPP1 DGKG PAFAH1B3

1.64e-041951175f9a90cd7b4e99a0947fdb3645f7787d02b0f7ca0
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

POLE FANCA CENPP FANCB DIAPH3

1.64e-041951175b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP73 CFAP65 GAS2L2 WDR90 CFAP46

1.64e-04195117579dc031258579ea328181dda33710dd897f1064a
ToppCellFibroblasts-Pericytes|Fibroblasts / lung cells shred on cell class, cell subclass, sample id

PRUNE2 DGKG ADCY5 FRY SYNE2

1.64e-041951175c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

POLE FANCA CENPP FANCB DIAPH3

1.64e-04195117556d8734d020b3da08a5aa9e67999706a9e023a99
ToppCellsevere-B_cell|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DENND5B HGD FANCM PKHD1L1 PTPRO

1.64e-0419511750fc3c605609c9e6bdea15d73c45def2188ae5fb1
ToppCell(5)_Fibroblasts-(5)_Fibroblast-K_(Pericytes)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

PRUNE2 EPS8 DGKG ADCY5 FRY

1.68e-041961175541b1fcf509e362f6f48720046cb5378aaf7c591
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 ENPP1 DGKG ADCY5 PRDM6

1.68e-0419611759830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP73 CFAP65 SYNE2 WDR90 CFAP46

1.72e-04197117574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1B GABRG3 ITPR1 FRY UNC80

1.76e-041981175c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1B GABRG3 ITPR1 FRY UNC80

1.76e-0419811758ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1B GABRG3 ITPR1 FRY UNC80

1.76e-0419811754ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 RANBP17 NF1 DIAPH2 FHIP1A

1.76e-0419811751996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

DOCK4 EPS8 MDN1 SYNE2 DIAPH2

1.76e-041981175b8bd1ba268480f54451648e01631b615a3401144
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 ENPP1 DGKG ADCY5 PRDM6

1.76e-041981175d1827e3707b929e3a3562989a0c11537d344e164
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PRUNE2 ENPP1 DGKG ADCY5 ITPR1

1.76e-0419811751e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

EPS8 ATRX BAZ2B SYNE2 SMARCA2

1.81e-041991175c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

POLE FANCA CENPP FANCB DIAPH3

1.81e-0419911751d5a3366474c17e3df0ba5cf11b586655529e9bd
ToppCellLPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

HGD DYM DGKG PKHD1L1 TRPM1

1.85e-042001175326cae37cacd94b423a6ac8873ea56c5abaf0a0b
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

POLE FANCA CENPP FANCB DIAPH3

1.85e-042001175af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Neuronal-Intermediate|2m / Sample Type, Dataset, Time_group, and Cell type.

BAZ2B FRY NF1 PTPRO SYNE2

1.85e-0420011752a635694844ddabcd98462c5636a6f41a3f08a46
Diseasenon-syndromic intellectual disability (implicated_via_orthology)

TECR TECRL

1.43e-0521122DOID:0050889 (implicated_via_orthology)
DiseaseBone marrow hypocellularity

FANCM FANCA FANCB

4.17e-05181123C1855710
Diseaseautosomal dominant auditory neuropathy 1 (implicated_via_orthology)

DIAPH2 DIAPH3

4.27e-0531122DOID:0060690 (implicated_via_orthology)
DiseaseTreacher Collins syndrome

POLR1D POLR1B

8.53e-0541122cv:C0242387
DiseaseFanconi Anemia

FANCM FANCA FANCB

1.15e-04251123C0015625
DiseaseMYELODYSPLASTIC SYNDROME

ATRX FANCM FANCA FANCB

1.25e-04671124C3463824
DiseasePancytopenia

FANCM FANCA FANCB

1.30e-04261123C0030312
DiseaseAcute monocytic leukemia

FANCM FANCA FANCB

1.30e-04261123C0023465
DiseaseMandibulofacial dysostosis

POLR1D POLR1B

1.42e-0451122cv:CN004722
DiseaseMiller Dieker syndrome

FANCM FANCA FANCB

1.81e-04291123C0265219
DiseaseTreacher Collins syndrome (implicated_via_orthology)

POLR1D POLR1B

2.12e-0461122DOID:2908 (implicated_via_orthology)
Diseasewaist-hip ratio

PRUNE2 VPS11 DYM IPO8 KLF6 DGKG ADCY5 ADCY8 NUP205 CFAP65 THADA SYNE2 EFR3B HTT

2.29e-04122611214EFO_0004343
DiseaseAbnormality of radial ray

FANCM FANCA FANCB

2.67e-04331123C4228778
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1B SCYL1

2.96e-0471122DOID:0050951 (implicated_via_orthology)
Diseasepantothenate measurement

SLC30A3 PANK2

3.94e-0481122EFO_0021034
Diseaseprimary ovarian insufficiency (is_implicated_in)

FANCA DIAPH2

3.94e-0481122DOID:5426 (is_implicated_in)
DiseaseAdenoid Cystic Carcinoma

ATRX FANCA SMARCA2 PRKDC

5.83e-041001124C0010606
DiseaseMalignant Head and Neck Neoplasm

FANCM FANCA FANCB

6.29e-04441123C0278996
Diseaseinsulin sensitivity measurement, response to polyunsaturated fatty acid supplementation

EPS8 PTPRO

7.68e-04111122EFO_0004471, EFO_0009131
DiseaseRespiratory Depression

CACNA1S SLC23A1

1.08e-03131122C0235063
DiseaseRespiratory Insufficiency

CACNA1S SLC23A1

1.08e-03131122C0035229
DiseaseRespiratory Failure

CACNA1S SLC23A1

1.08e-03131122C1145670
DiseaseFanconi anemia

FANCA FANCB

1.26e-03141122cv:C0015625
DiseaseBenign neoplasm of stomach

KLF6 POLE

1.87e-03171122C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

KLF6 POLE

1.87e-03171122C0496905
DiseaseCarcinoma in situ of stomach

KLF6 POLE

1.87e-03171122C0154060
Diseasesphingomyelin 14:0 measurement

THADA SYNE2

1.87e-03171122EFO_0010390
Diseasedermatomyositis (is_marker_for)

TLR9 SLIT2

1.87e-03171122DOID:10223 (is_marker_for)
Diseaseobstructive sleep apnea

DGKG CENPP THADA

2.05e-03661123EFO_0003918
Diseasesinusitis (is_marker_for)

MUC5B TLR9

2.10e-03181122DOID:0050127 (is_marker_for)
Diseasedehydroepiandrosterone sulphate measurement

DOCK4 TECRL THADA

2.23e-03681123EFO_0007001
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

SLIT2 GAS2L2

2.34e-03191122DOID:9562 (implicated_via_orthology)
Diseasedentures

PRUNE2 ADCY8 PBX3

2.42e-03701123EFO_0010078
Diseasedental caries, dentures

PRUNE2 ADCY8 PBX3

2.42e-03701123EFO_0003819, EFO_0010078
DiseaseAdenocarcinoma of prostate

KLF6 FANCA

2.59e-03201122C0007112
Diseasedilated cardiomyopathy

ZBTB17 FMNL3

2.59e-03201122EFO_0000407
Diseasebody fat percentage

DYM SCYL1 ADCY5 ADCY8 FANCA RANBP17 HTT

2.64e-034881127EFO_0007800
Diseaseaspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement

SCYL1 ADCY5 ADCY8 FANCA RANBP17 HTT

2.70e-033641126EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
DiseaseStomach Carcinoma

KLF6 POLE

2.86e-03211122C0699791
Diseasecardiovascular system disease (is_implicated_in)

ENPP1 TLR9

2.86e-03211122DOID:1287 (is_implicated_in)
Diseasetransient cerebral ischemia (biomarker_via_orthology)

ITPR1 SLIT2 NF1 HTT

3.07e-031571124DOID:224 (biomarker_via_orthology)
Diseasemalignant astrocytoma (is_marker_for)

ATRX NF1

3.43e-03231122DOID:3069 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
ISINQVVAQAVLFMC

ADCY8

316

P40145
RTLEECFQMFQTIHQ

ADAL

61

Q6DHV7
QQFPFCLMSVNITHI

ELMOD3

246

Q96FG2
CLMSVNITHIAIQAL

ELMOD3

251

Q96FG2
RCLFQLETVAVTQMN

ACTL8

196

Q9H568
MCNEVIQDFQASVLQ

ACTL6B

251

O94805
VSEILQIFMEAHCGQ

BAZ2B

1176

Q9UIF8
IQMTIFHCADNFARQ

GVINP1

971

Q7Z2Y8
LCVTEQHFNLLNEMP

CFAP46

2151

Q8IYW2
QNLILNMNDHGFVVC

PGD

16

P52209
CIQQFFEAMNHDLEL

CALHM1

246

Q8IU99
QQLQDASMQCVLTFE

GLE1

391

Q53GS7
IMTFTCHNEINAFVV

AASDH

666

Q4L235
ILIMAVLCNRAAFHQ

ADCY5

281

O95622
EALQLQVACMQFINA

DIAPH2

321

O60879
RHNSVQLQVACMQLI

DIAPH3

331

Q9NSV4
QLQVACMQLINALVT

DIAPH3

336

Q9NSV4
SRMAVLNLFQLVCQH

CFAP73

251

A6NFT4
LFHSCLNAVAELMQF

DGAT1

341

O75907
LEAFCQMIQAVHRSL

CCDC197

96

Q8NCU1
VVALNTLCVAMVHYN

CACNA1B

491

Q00975
IYQALCEHVQTQMSL

CCDC14

206

Q49A88
CHMVTFQLEFQILEI

CENPP

111

Q6IPU0
EDQILFNAHMGICVQ

MUC5B

5396

Q9HC84
LLECLTQDHMSFIIN

RANBP17

891

Q9H2T7
KNHQEVDMNVVRICF

RELB

256

Q01201
LCQVILTSSMAQHLQ

NUP205

1626

Q92621
VVFIGDSLVQLMHQC

PAFAH1B3

41

Q15102
MAHINCTQATEFILV

OR8U8

1

P0C7N1
MSSLEFCNAVIQVAH

FHIP1B

301

Q8N612
EQACNEFTTHVMNLL

PBX3

171

P40426
QACNEFTTHVMNLLR

PBX2

181

P40425
CQLFSIHVDAINIMV

KIAA0100

131

Q14667
QAVMLIHQQLCLNFA

MDN1

3621

Q9NU22
QHLAMQCQILLEQLS

MDN1

4291

Q9NU22
QEIMRLAHEFLQNFC

ITPR1

1241

Q14643
ELHQMRVQDNCLFSI

CFAP65

1226

Q6ZU64
IEQIQHLQSMFERIC

FANCM

1881

Q8IYD8
QCHMFTDQIKVLQQR

MORC3

716

Q14149
EFNICLAQMFLIHAL

OR51D1

106

Q8NGF3
NITFDACLIQMFLIH

OR51I2

91

Q9H344
DQLLMACHCQSINLF

EFR3B

81

Q9Y2G0
QKENTICLLSQHQFM

ENPP1

666

P22413
CEALLMVQAFHANII

POLE

501

Q07864
NNIINHFTCEILAVM

OR13C5

171

Q8NGS8
NNIINHFTCEILAVM

OR13C2

171

Q8NGS9
MLANHILETQTISFC

OR1F1

81

O43749
TEEQYIFIHQCVQLM

PTPRO

1181

Q16827
TFTQRILLQMHVCTQ

PRDM6

481

Q9NQX0
SRNQTVMFQCLHNLI

FANCB

721

Q8NB91
RMCALNENINQVVFV

PANK2

506

Q9BZ23
SIMNLTFCADNLVNH

OR8B12

161

Q8NGG6
DCIVNQMLHIAQYLE

DGKG

201

P49619
LQNNLIEYHCMVNFI

ATRX

1751

P46100
VQFMQNFRDVCIHQD

CSGALNACT2

286

Q8N6G5
MNSLEFCNAVIQVAH

FHIP1A

286

Q05DH4
YHQVLEMFILVLQQC

HTT

1581

P42858
VQAQAISCLQQLHMF

HEATR5A

1041

Q86XA9
ILANIGDHFCQMVIS

KDM3A

621

Q9Y4C1
AVIFINQLCLQLEMF

DOCK4

1011

Q8N1I0
VFICQMSEEELQLHF

DYM

116

Q7RTS9
TINAECQLQLHNFPM

GABRG3

166

Q99928
HVVQCMFVAISTIGN

CACNA1S

916

Q13698
ALLQGNHQIVEMCYQ

COPA

681

P53621
QLEMGLESFCTNHIQ

FRMPD1

1051

Q5SYB0
CHFRNLDQMVQSLVS

GAS2L2

201

Q8NHY3
MKCLQQALHTFQNDI

DHCR24

391

Q15392
IIFMQTACQAVQHQR

DIS3L

81

Q8TF46
VACMQFINIVVHSVE

FMNL3

321

Q8IVF7
HMAVDLLLTSFCQNL

FANCA

716

O15360
QAVHCARNIVLSFML

BCE1

61

O60756
ENLVQVFTCVLLEMQ

DENND5B

281

Q6ZUT9
VISNMNNSPFDLCHV

LYST

246

Q99698
CIQMALQAHYDVIVL

FAM172BP

141

A6NC97
ENFPLNTIQHCQAVM

EPS8

126

Q12929
RAHFSAMVANLIQCV

FRY

1091

Q5TBA9
EHMILCRFADQTAVQ

GSTCD

566

Q8NEC7
LCSQLQHMSLQIAAD

CPHXL

366

A0A1W2PPM1
KLVQLTFCAFHDMIQ

CROT

591

Q9UKG9
ACINLNIIIHIQSNM

PTCD2

271

Q8WV60
LAIHIFLCNTSMENR

HGD

131

Q93099
HIQNISEDVIFSVMC

IPO8

346

O15397
NICTARNMAHSQVLQ

NOXRED1

246

Q6NXP6
FQVNMLDCQPVHEQA

NXT2

71

Q9NPJ8
MAHINCTQATEFILV

OR8U1

1

Q8NH10
FQRGLNELMNVCQHV

POLR1D

96

P0DPB6
ACHLFVINMNEIVRT

TAS2R43

141

P59537
FAEMANILVIHCQTT

VAC14

256

Q08AM6
LQRMVSEQCHLLSQF

THADA

1871

Q6YHU6
TVSMNLENCLFHSNI

PRUNE2

246

Q8WUY3
LMEQVPHIALFCQEN

PPP4R1

106

Q8TF05
VMLLCHNAQTFNLEG

SMARCA2

1471

P51531
LRQSLMQCQDFHQLS

SYNE2

6656

Q8WXH0
SLIHNNVCMAAVFVD

SCYL1

136

Q96KG9
ALCNIVNNKMVHFDL

HUS1

251

O60921
AITTQCNCMHFLVVI

SATL1

641

Q86VE3
VQEVACLFNTVMLQL

URB1

2166

O60287
SMELVIQFQVLNQSC

WDR90

1466

Q96KV7
MFNENCFLVQHEQIL

ZNF460

176

Q14592
TVVSCLTVHENLNFM

VPS11

141

Q9H270
ASFLQMQHIIDKCTQ

ZBTB37

106

Q5TC79
HVMILLCNQQSFICT

UNC80

1461

Q8N2C7
EHFVVCNRSNTVVIM

SMU1

411

Q2TAY7
VHNTVNAINLMCTIA

SPO16

121

Q5VVC0
QHMVSQLIGTIFTCV

SLC23A1

76

Q9UHI7
TVQPEMFAQLSHLQC

TLR9

486

Q9NR96
HAIACVNQFIMDRAQ

TNPO2

191

O14787
VVCRQMLEALNFLHS

STK10

136

O94804
TFMHQECEAIVQSII

NF1

1811

P21359
FVICQLGNFSIHMAL

TECR

201

Q9NZ01
AIQTMHLAQNPFICD

SLIT2

421

O94813
QNERCLHMFLQDEII

SNX3

136

O60493
FEILEISVMINNIQC

PKHD1L1

1941

Q86WI1
QHQNTMEDKFIVCLN

PRKDC

2351

P78527
IAVCANLLMAFVLHQ

SLC30A3

186

Q99726
NKAQSHQLFAIIMEC

TRPM1

321

Q7Z4N2
QNHADIVSCVAMVFL

TRAM1

21

Q15629
ATFLQMQDIITACHA

ZBTB17

96

Q13105
MIVIHDSVIQECVQF

TTC30A

601

Q86WT1
VAIINNSMCNHLFLK

PRSS21

196

Q9Y6M0
NFLICEAGNHFINVM

TECRL

256

Q5HYJ1
MNHLTAVCEVVTQFV

POLR1B

511

Q9H9Y6
IVSLHNFLSVLFQCM

WDR91

156

A4D1P6
LMVQTEAQYVFLHQC

PTPRH

1061

Q9HD43
QAVSLAACHLLQVMF

UNC45A

251

Q9H3U1
FLQMTDIVQACHDFI

ZBTB46

111

Q86UZ6
MCSIFQELQIVHETG

KLF6

6

Q99612