Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR1B1 OR6K2 OR4D9 ADGRB3 ADGRV1 PTGER4 GALR2 OR10D4P OR10D3 CELSR3 OR11A1 P2RY2 OR10G3 OR10G2 HRH4 OR1K1	5.21e-06	884	97	16	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR1B1 OR6K2 OR4D9 ADGRB3 GRIN2A ADGRV1 PTGER4 GALR2 OR10D4P OR10D3 CELSR3 OR11A1 P2RY2 OR10G3 OR10G2 HRH4 OR1K1 NOTCH1	8.04e-05	1353	97	18	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR1B1 OR6K2 OR4D9 OR10D4P OR10D3 OR11A1 OR10G3 OR10G2 OR1K1	2.50e-04	431	97	9	GO:0004984
Domain	ADAM_spacer1	PAPLN ADAMTS10 ADAMTSL5 ADAMTS20	5.16e-06	23	95	4	IPR010294
Domain	ADAM_spacer1	PAPLN ADAMTS10 ADAMTSL5 ADAMTS20	5.16e-06	23	95	4	PF05986
Domain	Peptidase_M12B_ADAM-TS	PAPLN ADAMTS10 ADAMTSL5 ADAMTS20	6.17e-06	24	95	4	IPR013273
Domain	TSP_1	ADGRB3 PAPLN ADAMTS10 ADAMTSL5 ADAMTS20	1.70e-05	63	95	5	PF00090
Domain	TSP1	ADGRB3 PAPLN ADAMTS10 ADAMTSL5 ADAMTS20	1.99e-05	65	95	5	SM00209
Domain	TSP1_rpt	ADGRB3 PAPLN ADAMTS10 ADAMTSL5 ADAMTS20	1.99e-05	65	95	5	IPR000884
Domain	TSP1	ADGRB3 PAPLN ADAMTS10 ADAMTSL5 ADAMTS20	1.99e-05	65	95	5	PS50092
Domain	Wnt3	WNT3 WNT3A	2.56e-05	2	95	2	IPR009141
Domain	PLAC	PAPLN ADAMTS10 PCSK6	4.46e-05	14	95	3	PF08686
Domain	PLAC	PAPLN ADAMTS10 PCSK6	1.16e-04	19	95	3	PS50900
Domain	PLAC	PAPLN ADAMTS10 PCSK6	1.16e-04	19	95	3	IPR010909
Domain	VDCC_L_a1su	CACNA1C CACNA1S	1.53e-04	4	95	2	IPR005446
Domain	Channel_four-helix_dom	CACNA1C CACNA1S KCNV2 KCNA4	2.02e-04	57	95	4	IPR027359
Domain	-	CACNA1C CACNA1S KCNV2 KCNA4	2.02e-04	57	95	4	1.20.120.350
Domain	VDCC_a1su_IQ	CACNA1C CACNA1S	5.29e-04	7	95	2	IPR014873
Domain	GPHH	CACNA1C CACNA1S	5.29e-04	7	95	2	PF16905
Domain	GPHH_dom	CACNA1C CACNA1S	5.29e-04	7	95	2	IPR031649
Domain	Ca_chan_IQ	CACNA1C CACNA1S	5.29e-04	7	95	2	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1S	5.29e-04	7	95	2	PF08763
Domain	GPCR_Rhodpsn_7TM	OR1B1 OR6K2 OR4D9 PTGER4 GALR2 OR11A1 P2RY2 OR10G3 OR10G2 HRH4 OR1K1	5.91e-04	670	95	11	IPR017452
Domain	7tm_1	OR1B1 OR6K2 OR4D9 PTGER4 GALR2 OR11A1 P2RY2 OR10G3 OR10G2 HRH4 OR1K1	6.44e-04	677	95	11	PF00001
Domain	GPS	ADGRB3 ADGRV1 CELSR3	6.80e-04	34	95	3	SM00303
Domain	G_PROTEIN_RECEP_F1_1	OR1B1 OR6K2 OR4D9 PTGER4 GALR2 OR11A1 P2RY2 OR10G3 OR10G2 HRH4 OR1K1	7.09e-04	685	95	11	PS00237
Domain	GPS	ADGRB3 ADGRV1 CELSR3	7.42e-04	35	95	3	PF01825
Domain	G_PROTEIN_RECEP_F1_2	OR1B1 OR6K2 OR4D9 PTGER4 GALR2 OR11A1 P2RY2 OR10G3 OR10G2 HRH4 OR1K1	7.62e-04	691	95	11	PS50262
Domain	GPCR_Rhodpsn	OR1B1 OR6K2 OR4D9 PTGER4 GALR2 OR11A1 P2RY2 OR10G3 OR10G2 HRH4 OR1K1	7.71e-04	692	95	11	IPR000276
Domain	GPS	ADGRB3 ADGRV1 CELSR3	8.06e-04	36	95	3	PS50221
Domain	GPS	ADGRB3 ADGRV1 CELSR3	8.74e-04	37	95	3	IPR000203
Domain	G_PROTEIN_RECEP_F2_1	ADGRB3 ADGRV1 CELSR3	1.10e-03	40	95	3	PS00649
Domain	GPCR_2_extracellular_dom	ADGRB3 ADGRV1 CELSR3	1.10e-03	40	95	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	ADGRB3 ADGRV1 CELSR3	1.10e-03	40	95	3	PS50227
Domain	VDCCAlpha1	CACNA1C CACNA1S	1.12e-03	10	95	2	IPR002077
Domain	GAIN_dom_N	ADGRB3 CELSR3	1.37e-03	11	95	2	IPR032471
Domain	GAIN	ADGRB3 CELSR3	1.37e-03	11	95	2	PF16489
Domain	G_PROTEIN_RECEP_F2_2	ADGRB3 ADGRV1 CELSR3	2.10e-03	50	95	3	PS00650
Domain	7tm_2	ADGRB3 ADGRV1 CELSR3	2.10e-03	50	95	3	PF00002
Domain	Ras_G-nucl-exch_fac_CS	RAPGEF1 RGL2	2.24e-03	14	95	2	IPR019804
Domain	CUB	ADGRB3 CSMD1 TMPRSS7	2.48e-03	53	95	3	PS01180
Domain	Ion_trans_dom	CACNA1C CACNA1S KCNV2 KCNA4	2.74e-03	114	95	4	IPR005821
Domain	Ion_trans	CACNA1C CACNA1S KCNV2 KCNA4	2.74e-03	114	95	4	PF00520
Domain	PH_DOMAIN	ASAP3 IRS1 SNTG2 AGAP9 RASAL1 PHLPP2	3.02e-03	279	95	6	PS50003
Domain	CUB_dom	ADGRB3 CSMD1 TMPRSS7	3.06e-03	57	95	3	IPR000859
Domain	GPCR_2_secretin-like	ADGRB3 ADGRV1 CELSR3	3.54e-03	60	95	3	IPR000832
Domain	GPCR_2-like	ADGRB3 ADGRV1 CELSR3	3.54e-03	60	95	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRB3 ADGRV1 CELSR3	3.71e-03	61	95	3	PS50261
Domain	Olfact_rcpt	OR1B1 OR6K2 OR4D9 OR11A1 OR10G3 OR10G2 OR1K1	3.92e-03	393	95	7	IPR000725
Domain	Wnt	WNT3 WNT3A	4.14e-03	19	95	2	IPR005817
Domain	Wnt_CS	WNT3 WNT3A	4.14e-03	19	95	2	IPR018161
Domain	wnt	WNT3 WNT3A	4.14e-03	19	95	2	PF00110
Domain	WNT1	WNT3 WNT3A	4.14e-03	19	95	2	SM00097
Domain	WNT1	WNT3 WNT3A	4.14e-03	19	95	2	PS00246
Domain	RasGEFN	RAPGEF1 RGL2	4.58e-03	20	95	2	SM00229
Domain	RasGEF_N	RAPGEF1 RGL2	5.05e-03	21	95	2	PF00618
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	WNT3 ADGRB3 PAPLN ADAMTS10 ADAMTSL5 ADAMTS20	7.84e-08	75	99	6	20637190
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	RAPGEF1 SHROOM2 CELSR3 TULP4 SYNJ2 SLCO2A1 APOL5 RGL2	4.78e-06	329	99	8	17474147
Pubmed	Temporal expression of calcium channel subunits in satellite cells and bone marrow mesenchymal cells.	CACNA1C CACNA1S	8.02e-06	2	99	2	25277766
Pubmed	A single nucleotide deletion in the skeletal muscle-specific calcium channel transcript of muscular dysgenesis (mdg) mice.	CACNA1C CACNA1S	8.02e-06	2	99	2	1281468
Pubmed	Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes.	TBC1D4 ARID5B	8.02e-06	2	99	2	34265779
Pubmed	Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation.	WNT3A NOTCH1	8.02e-06	2	99	2	21308863
Pubmed	Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45.	WNT3 WNT3A	8.02e-06	2	99	2	11788904
Pubmed	Endogenous cardiac Ca2+ channels do not overcome the E-C coupling defect in immortalized dysgenic muscle cells: evidence for a missing link.	CACNA1C CACNA1S	8.02e-06	2	99	2	7635187
Pubmed	Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.	WNT3 WNT3A	8.02e-06	2	99	2	2001840
Pubmed	NKAP alters tumor immune microenvironment and promotes glioma growth via Notch1 signaling.	NKAP NOTCH1	8.02e-06	2	99	2	31277684
Pubmed	Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits.	WNT3 GRIN2A NOTCH1	1.77e-05	18	99	3	9011744
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ESPN CACNA1C LIMD1 WWP2 ADGRV1 SHROOM2 BRWD3 SENP1 TBC1D4 TULP4 SYNJ2 PKP3 ARID5B SNTG2 CSMD1	2.03e-05	1489	99	15	28611215
Pubmed	Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels.	CACNA1C CACNA1S	2.40e-05	3	99	2	9668070
Pubmed	Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.	CACNA1C CACNA1S	2.40e-05	3	99	2	17289261
Pubmed	Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling.	WNT3 WNT3A	2.40e-05	3	99	2	20722074
Pubmed	Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.	WNT3 WNT3A	2.40e-05	3	99	2	26902720
Pubmed	Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).	CACNA1C CACNA1S	2.40e-05	3	99	2	17767505
Pubmed	Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling.	RAPGEF1 NOTCH1	2.40e-05	3	99	2	18180377
Pubmed	Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.	CACNA1C CACNA1S	2.40e-05	3	99	2	11206130
Pubmed	Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.	CACNA1C CACNA1S	2.40e-05	3	99	2	2173707
Pubmed	mRNA for cardiac calcium channel is expressed during development of skeletal muscle.	CACNA1C CACNA1S	2.40e-05	3	99	2	8381753
Pubmed	The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.	CACNA1C KCNV2	2.40e-05	3	99	2	33597309
Pubmed	Novel roles for Notch, Wnt and Hedgehog in hematopoesis derived from human pluripotent stem cells.	WNT3A NOTCH1	2.40e-05	3	99	2	20336604
Pubmed	Crystal structure of a mammalian Wnt-frizzled complex.	WNT3 WNT3A	2.40e-05	3	99	2	31036956
Pubmed	lncRNA BREA2 promotes metastasis by disrupting the WWP2-mediated ubiquitination of Notch1.	WWP2 NOTCH1	2.40e-05	3	99	2	36795754
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KRT78 LIMD1 RTCB WWP2 IRS1 TBC1D4 SYNJ2 MAP3K10 KIF14 USP54 RGL2	3.49e-05	861	99	11	36931259
Pubmed	GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo.	WNT3A NOTCH1	4.79e-05	4	99	2	21319221
Pubmed	Wnt signaling controls the timing of oligodendrocyte development in the spinal cord.	WNT3 WNT3A	4.79e-05	4	99	2	15950605
Pubmed	Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1.	TULP4 SYNJ2	4.79e-05	4	99	2	11471064
Pubmed	Role of insulin receptor substrates in the progression of hepatocellular carcinoma.	IRS1 WNT3A	4.79e-05	4	99	2	28710407
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1S	4.79e-05	4	99	2	20937870
Pubmed	Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.	KCNA4 NOTCH1	4.79e-05	4	99	2	9169836
Pubmed	A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells.	TNP2 TARBP2	4.79e-05	4	99	2	10369260
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR1B1 OR6K2 OR10D4P OR10D3 OR11A1 OR10G3 OR10G2	5.53e-05	340	99	7	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR1B1 OR6K2 OR10D4P OR10D3 OR11A1 OR10G3 OR10G2	5.53e-05	340	99	7	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR1B1 OR6K2 OR10D4P OR10D3 OR11A1 OR10G3 OR10G2	5.84e-05	343	99	7	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR1B1 OR6K2 OR10D4P OR10D3 OR11A1 OR10G3 OR10G2	6.17e-05	346	99	7	14611657
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZBTB4 RAPGEF1 PAPLN IRS1 BAHD1 TKFC CELSR3 ADAMTSL5 TULP4 RGL2 NOTCH1 RASAL1	7.26e-05	1105	99	12	35748872
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRB3 ADGRV1 CELSR3	7.75e-05	29	99	3	15203201
Pubmed	A role for Wnt signalling in self-renewal of haematopoietic stem cells.	WNT3A NOTCH1	7.98e-05	5	99	2	12717450
Pubmed	Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression.	WNT3A NOTCH1	7.98e-05	5	99	2	11447280
Pubmed	Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex.	WNT3 WNT3A	7.98e-05	5	99	2	15143193
Pubmed	Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli.	WNT3 WNT3A	7.98e-05	5	99	2	18716223
Pubmed	In vivo identification of eugenol-responsive and muscone-responsive mouse odorant receptors.	OR10D4P OR10D3	7.98e-05	5	99	2	25411495
Pubmed	Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases.	GRIN2A KCNA4	7.98e-05	5	99	2	8601796
Pubmed	The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1.	CACNA1C CACNA1S	7.98e-05	5	99	2	1335956
Pubmed	Local and cis effects of the H element on expression of odorant receptor genes in mouse.	OR10G3 OR10G2	7.98e-05	5	99	2	17662950
Pubmed	NOTCH maintains developmental cardiac gene network through WNT5A.	WNT3 WNT3A NOTCH1	1.05e-04	32	99	3	30347193
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRB3 ADGRV1 CELSR3	1.15e-04	33	99	3	25713288
Pubmed	Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice.	PTGER4 SLCO2A1	1.19e-04	6	99	2	20083684
Pubmed	Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.	WNT3 WNT3A	1.19e-04	6	99	2	8168088
Pubmed	Exploring the formation mechanism of short-tailed phenotypes in animals using mutant mice with the TBXT gene c.G334T developed by CRISPR/Cas9.	WNT3 WNT3A	1.19e-04	6	99	2	38401832
Pubmed	Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.	WNT3 WNT3A	1.19e-04	6	99	2	10557084
Pubmed	A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo.	WNT3 WNT3A	1.19e-04	6	99	2	14723853
Pubmed	TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway.	TARBP2 NOTCH1	1.19e-04	6	99	2	28174252
Pubmed	Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.	WNT3 GRIN2A WNT3A	1.26e-04	34	99	3	28069946
Pubmed	The human olfactory receptor gene family.	OR1B1 OR6K2 OR4D9 OR10D4P OR10D3 OR11A1 OR10G3 OR10G2	1.61e-04	541	99	8	14983052
Pubmed	Dishevelled-2 docks and activates Src in a Wnt-dependent manner.	WNT3 WNT3A	1.67e-04	7	99	2	19920076
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1S	1.67e-04	7	99	2	12900400
Pubmed	Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin.	CACNA1C CACNA1S	1.67e-04	7	99	2	9004034
Pubmed	Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.	WNT3 WNT3A	1.67e-04	7	99	2	18413325
Pubmed	Wnt3a plays a major role in the segmentation clock controlling somitogenesis.	WNT3A NOTCH1	2.22e-04	8	99	2	12636920
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	ADGRB3 GRIN2A KCNA4 TULP4 MAP3K10	2.58e-04	197	99	5	36604605
Pubmed	Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.	WNT3 WNT3A	2.85e-04	9	99	2	16890161
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1C CACNA1S	2.85e-04	9	99	2	16382099
Pubmed	Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation.	WNT3 WNT3A	2.85e-04	9	99	2	18986540
Pubmed	microRNA-184 Induces a Commitment Switch to Epidermal Differentiation.	FLG2 NOTCH1	2.85e-04	9	99	2	29198823
Pubmed	Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.	KCNA4 WNT3A	2.85e-04	9	99	2	12067714
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	WNT3 CELSR3 WNT3A	3.31e-04	47	99	3	33141892
Pubmed	Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.	WNT3 WNT3A	3.56e-04	10	99	2	8275860
Pubmed	Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.	WNT3A NOTCH1	3.56e-04	10	99	2	16516838
Pubmed	Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells.	RAPGEF1 IRS1	3.56e-04	10	99	2	16455755
Pubmed	The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.	WNT3 WNT3A	3.56e-04	10	99	2	10866835
Pubmed	Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2S252W/+ ) mouse model.	WNT3 WNT3A	3.56e-04	10	99	2	32822074
Pubmed	Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones.	OR10G3 OR10G2	5.20e-04	12	99	2	9110172
Pubmed	ILDR2 stabilization is regulated by its interaction with GRP78.	MYO1G SENP1	5.20e-04	12	99	2	33863978
Pubmed	Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo.	WNT3 WNT3A	5.20e-04	12	99	2	15778975
Pubmed	Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development.	WNT3 WNT3A	5.20e-04	12	99	2	21246653
Pubmed	Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway.	WNT3 WNT3A	5.20e-04	12	99	2	19690384
Pubmed	Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.	GRIN2A KCNA4	5.20e-04	12	99	2	11937501
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS10 ADAMTS20	5.20e-04	12	99	2	25770910
Pubmed	YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues.	WNT3A NOTCH1	5.20e-04	12	99	2	25691658
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	BAHD1 TBC1D4 CELSR3 SYNJ2	5.33e-04	130	99	4	12421765
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	LIMD1 ZC3H13 RAPGEF1 PDE8B	5.81e-04	133	99	4	15144186
Pubmed	DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.	ESPN KRT78 KPRP FLG2 PKP3	6.10e-04	238	99	5	35864588
Pubmed	The role of presenilin 1 during somite segmentation.	WNT3A NOTCH1	6.13e-04	13	99	2	11262239
Pubmed	Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation.	WNT3 WNT3A	6.13e-04	13	99	2	19841259
Pubmed	Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development.	WNT3 WNT3A	6.13e-04	13	99	2	22024319
Pubmed	Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice.	WNT3 WNT3A	6.13e-04	13	99	2	34679163
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1C CACNA1S KCNV2 KCNA4	6.85e-04	139	99	4	16985003
Pubmed	A mechanism for gene-environment interaction in the etiology of congenital scoliosis.	WNT3A NOTCH1	7.14e-04	14	99	2	22484060
Pubmed	Sequence and expression of murine type I hair keratins mHa2 and mHa3.	KIF12 KIF14	7.14e-04	14	99	2	7514534
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	ESPN ADGRV1	7.14e-04	14	99	2	26754646
Pubmed	Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.	WNT3A NOTCH1	7.14e-04	14	99	2	10090727
Pubmed	LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis.	WNT3A NOTCH1	7.14e-04	14	99	2	15545629
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	LIMD1 SENP1 SYNJ2 KIF14 NKAP USP54 NEURL4 TRIM37 ALDH7A1	7.45e-04	853	99	9	28718761
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	KRT78 FLG2 PKP3	7.49e-04	62	99	3	26644517
Pubmed	CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1.	KPRP PCSK6 ALDH7A1	8.22e-04	64	99	3	36369321
Pubmed	Expression patterns of Wnt genes in mouse gut development.	WNT3 WNT3A	8.22e-04	15	99	2	11429295
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1C CACNA1S	8.22e-04	15	99	2	20188150
GeneFamily	Olfactory receptors, family 10	OR10D4P OR10D3 OR10G3 OR10G2	1.71e-04	66	76	4	157
GeneFamily	ADAMTS like	PAPLN ADAMTSL5	3.61e-04	7	76	2	947
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ASAP3 IRS1 AGAP9 RASAL1 PHLPP2	1.75e-03	206	76	5	682
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ASAP3 AGAP9	2.28e-03	17	76	2	1291
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS10 ADAMTS20	2.85e-03	19	76	2	50
GeneFamily	Wnt family\|Endogenous ligands	WNT3 WNT3A	2.85e-03	19	76	2	360
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1S	5.31e-03	26	76	2	253
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QRFP MBOAT4 TBC1D4 FIBIN PKP3 HRH4	2.42e-06	176	97	6	8e4600efeea095a92178cfd26d7c58db7dfc0c80
ToppCell	LPS_only-Hematopoietic_Mast-Mast_cells-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1G RNF17 PTGER4 GALR2 ZP1	1.94e-05	150	97	5	ccb782fbcb3122266354a112a9a850506664f44d
ToppCell	LPS_only-Hematopoietic_Mast-Mast_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1G RNF17 PTGER4 GALR2 ZP1	1.94e-05	150	97	5	7290e9a812b1b2f919e67ccde0acf52687ab138f
ToppCell	LPS_only-Hematopoietic_Mast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1G RNF17 PTGER4 GALR2 ZP1	1.94e-05	150	97	5	2c5078a1f769ba8153dee756b53d28eb7b434a96
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO1G PTGER4 GALR2 ZP1 ADAMTSL5	2.00e-05	151	97	5	b85a763459a0f019d1f9975d09b9f2247d62c9d3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FN3KRP ADGRB3 ADAMTS10 SLCO2A1 SCNN1D	2.27e-05	155	97	5	59035d792c26d870a8b097939e97fa47859ba68c
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYO1G QRFP RIPOR2 GRAMD1A ALPK2	2.64e-05	160	97	5	4a0ae0a83a10dbfc13591f4d2228ba8bcd2c2275
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QRFP RIPOR2 RNF17 ADAMTSL5 KIF14	2.64e-05	160	97	5	9f24ee4fe1ba4590dce5dd4d43707fb007dca82f
ToppCell	droplet-Liver-Hepatocytes-24m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QRFP RIPOR2 RNF17 ADAMTSL5 KIF14	2.64e-05	160	97	5	3b3b99305558f5b49d050fb9b249007630ea9085
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C ADAMTSL5 OR11A1 OR10G3 CSMD1	2.89e-05	163	97	5	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	PND14-Immune-Immune_Myeloid-DC-maDC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1S PTGER4 TBC1D4 TNP2 RASAL1	3.06e-05	165	97	5	1c3709ac9f96ace1f3b28e1f2f15b4a8d65885ca
ToppCell	PND14-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1S PTGER4 TBC1D4 TNP2 RASAL1	3.06e-05	165	97	5	fbc7d97e6f30975d35c76a7c97947a34cf5975d2
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHOD3 GALR2 ADAMTSL5 SYNJ2 NEURL4	3.15e-05	166	97	5	35db3022c33d6f8bb6587d9eec89a7cccb70271a
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT3 MBOAT4 TBC1D4 PKP3 TNP2	3.53e-05	170	97	5	064786c1f1ad7665358964765910b0ad46d14685
ToppCell	droplet-Lung-nan-18m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT3 MBOAT4 TBC1D4 PKP3 TNP2	3.53e-05	170	97	5	6725747df336697708b94999b3ebb40f1721da16
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM2 TBC1D4 SCNN1D USP54 ALPK2	4.17e-05	176	97	5	33323c97afe509147956b8df9f92ca6b0537e604
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G CACNA1S PTGER4 TBC1D4 ALPK2	4.40e-05	178	97	5	0b456ac768e026c3ecd5a9a4f43d6f126e7685a1
Drug	Ketoprofen [22071-15-4]; Up 200; 15.8uM; MCF7; HT_HG-U133A	RIPOR2 KCNV2 ASAP3 ADGRB3 ZNF358 SLCO2A1 PCSK6 PHLPP2	1.96e-06	198	96	8	4751_UP
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1S	5.26e-05	4	88	2	DOID:0060173 (implicated_via_orthology)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1C CACNA1S SNTG2	1.70e-04	36	88	3	DOID:11723 (implicated_via_orthology)
Disease	hypokalemic periodic paralysis (implicated_via_orthology)	CACNA1S SCNN1D	2.43e-04	8	88	2	DOID:14452 (implicated_via_orthology)
Disease	Varicose veins	FHOD3 ADGRV1 ABHD16B PCSK6 ARID5B	2.87e-04	193	88	5	HP_0002619
Disease	carboxypeptidase B2 measurement	ZC3H13 SNTG2	3.90e-04	10	88	2	EFO_0008069
Disease	lactose measurement	ARID5B CSMD1	3.90e-04	10	88	2	EFO_0010507
Disease	triacylglycerol 52:1 measurement	RIPOR2 CSMD1	7.82e-04	14	88	2	EFO_0010413
Disease	response to olanzapine	CACNA1C ADGRV1	9.00e-04	15	88	2	GO_0097333
Disease	susceptibility to hepatitis B infection measurement	CACNA1C GRIN2A CSMD1	9.36e-04	64	88	3	EFO_0008405
Disease	interferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement	KCNV2 PCSK6	1.03e-03	16	88	2	EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
Disease	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	WNT3 NOTCH1	1.03e-03	16	88	2	C0334634
Disease	left ventricular mass	PDXDC1 ADAMTS10	1.30e-03	18	88	2	EFO_0009289
Disease	end stage renal disease (implicated_via_orthology)	IRS1 PTGER4	1.61e-03	20	88	2	DOID:783 (implicated_via_orthology)
Disease	Nonsyndromic Deafness	ESPN RIPOR2 ADGRV1	1.85e-03	81	88	3	C3711374
Disease	eye color	KCNA4 TULP4 CSMD1	2.50e-03	90	88	3	EFO_0003949
Disease	Involutional paraphrenia	CACNA1C GALR2	2.52e-03	25	88	2	C1571983
Disease	Psychosis, Involutional	CACNA1C GALR2	2.52e-03	25	88	2	C1571984
Disease	Involutional Depression	CACNA1C GALR2	2.52e-03	25	88	2	C0011574
Disease	TEMPS-A questionnaire	ADGRB3 CSMD1	2.52e-03	25	88	2	EFO_0004783
Disease	alpha-linolenic acid measurement	PDXDC1 CSMD1	2.52e-03	25	88	2	EFO_0007759
Disease	inflammatory biomarker measurement	KCNV2 PCSK6	2.73e-03	26	88	2	EFO_0004872
Disease	psychosis predisposition measurement	CACNA1C CSMD1	2.73e-03	26	88	2	EFO_0008337

Protein segments in the cluster

Peptide	Gene	Start	Entry
RCSPSERRGHSSSGK	C2orf16	1861	Q68DN1
SGRNHCSPSERSRRS	C2orf16	1921	Q68DN1
NRGLAGTTIRATACH	AMER2	651	Q8N7J2
SRTLVQGCARHASGD	ASAP3	761	Q8TDY4
QGCARHASGDRSEVS	ASAP3	766	Q8TDY4
ECSGIHRSFGTRLSR	AGAP9	546	Q5VTM2
HGSNTLTCLSGDRRV	CSMD1	1251	Q96PZ7
AAVGTAGQRCTTARR	ALDH7A1	321	P49419
ATGTTSRRCSLSLHG	ADGRB3	541	O60242
TGRSSHADARECAIS	ALPK2	591	Q86TB3
ERSSCANITVRRSGG	ADGRV1	2366	Q8WXG9
ITSARQLTGCSRFGH	BRWD3	146	Q6RI45
CARAGIHTSGSLSSR	GRAMD1A	576	Q96CP6
VGQRQRSVRCTSHTG	ADAMTS10	1021	Q9H324
SQCSRSCGGGERSRE	ADAMTS20	976	P59510
VGRSSSHRALTCAAA	ABHD16B	41	Q9H3Z7
QAERSAAGCSRTHSA	RASAL1	696	O95294
SCGSRHTAVVTRTGE	RCCD1	306	A6NED2
SAGGRRTAFSTCVSH	OR6K2	231	Q8NGY2
HSRGTVKCRHGSNSR	FLG2	146	Q5D862
GSERCSTAHTNGDRL	KIF14	606	Q15058
SAAGRRRAVSTCGSH	OR1B1	236	Q8NGR6
AGASRRRAFSTCSSH	OR11A1	231	Q9GZK7
GRQRAFSTCSAHLTA	OR10D4P	231	Q8NGN7
SNGSRHVCLRSGAGS	KRT28	6	Q7Z3Y7
TAACAVSRGHRRTPS	MAP3K10	816	Q02779
RAGHTGRRCESVING	NOTCH1	1296	P46531
TRHGSQDCGSRESLA	LIMD1	141	Q9UGP4
RRELGCSSVRATGHS	FN3KRP	6	Q9HA64
RRGQQSVLHCSGTRT	KIF12	41	Q96FN5
SCDGHDGLRRQDSSR	ESPN	491	B1AK53
TDLRQRCTDGHTGTS	PCSK6	406	P29122
IGGSRRERSGQHCSD	PTGER4	351	P35408
RERSGQHCSDSQRTS	PTGER4	356	P35408
SGVGRERHSCDALNR	PDXDC1	416	Q6P996
AATTSRGRRRHCCSS	PDE8B	86	O95263
GFSARSACSARSRGR	KRT78	11	Q8N1N4
TADGRRRAFSTCGAH	OR10G3	231	Q8NGC4
DPQGCRRRHSSETFS	IRS1	1091	P35568
FVTTSARGGRVTCHD	P2RY2	171	P41231
RCSSSCGRGVSVRSR	ADAMTSL5	56	Q6ZMM2
SASGRLRAVSTCGSH	OR1K1	231	Q8NGR3
RSHTGEGRRKAISTC	OR4D9	226	Q8NGE8
ARGLQTSGREHAGCR	QRFP	71	P83859
GRASGRVCAAARGTH	GALR2	316	O43603
RVCAAARGTHSGSVL	GALR2	321	O43603
AGHRRCSTSNTSAEN	CEMP1	11	Q6PRD7
HREAGGCVRGRTRSS	IGF2-AS	71	Q6U949
RRDSGSAGTQAHCLL	CACNA1C	1876	Q13936
ARTGSGRRCTINGSE	CACNA1S	246	Q13698
SGCRDRRRASVCSSG	FHOD3	336	Q2V2M9
RRRASVCSSGGGEHR	FHOD3	341	Q2V2M9
KSGLRTGSSCRHTAR	BAHD1	546	Q8TBE0
TGSSCRHTARSKAAR	BAHD1	551	Q8TBE0
SGGFRSRSSLSEHVC	MBOAT4	146	Q96T53
AENCRGHSSRRSEPS	MARCHF10	336	Q8NA82
GSFTEQHRSRSTSRC	KPRP	241	Q5T749
NGSHARCRCSRTGTF	CELSR3	2506	Q9NYQ7
FRVSDHRRCSQGEGS	FIBIN	56	Q8TAL6
SHSGSRVRVGFRLCN	SCNN1D	361	P51172
NGGRTALRHNCRSEF	NEURL4	731	Q96JN8
RSRSHSCSRSGDRNG	NKAP	41	Q8N5F7
SCSRSGDRNGLTHQL	NKAP	46	Q8N5F7
TEGRRRAFSTCSAHL	OR10D3	231	Q8NH80
TDGRRRAFSTCGSHL	OR10G2	236	Q8NGC3
HNSRARSTGACNCGR	SMG8	601	Q8ND04
SNICGHSFRGRLSSR	HRH4	221	Q9H3N8
TCHGAGRALSRAKSR	RTCB	426	Q9Y3I0
SRGHRRSASCGSPLS	RGL2	611	O15211
QTFSQSCRQSHRGSR	TNP2	31	Q05952
SCRQSHRGSRSQSSS	TNP2	36	Q05952
VGSSSRISRRTHLCS	TRIM37	591	O94972
GSRSCAESAVSRDHL	SMYD4	636	Q8IYR2
CERTGTRFHTRGVND	SYNJ2	211	O15056
HRRSICSLGARSGSQ	KCNV2	26	Q8TDN2
QGHLDRSFTCSTRSA	SENP1	51	Q9P0U3
VCERGSQHVSGDASR	SHROOM2	1131	Q13796
RNNSQVGFRCRGHST	SECISBP2L	341	Q93073
VGFRCRGHSTSSERR	SECISBP2L	346	Q93073
CVGGSHQGRNRRTVT	SNTG2	61	Q9NY99
SEACRRQSSGAGAEH	RIPOR2	516	Q9Y4F9
QTCSSSRGRAVRGSR	APOL5	356	Q9BWW9
GSTSAATCTRRHYER	ARID5B	386	Q14865
QCTRCGRRVSRSSGH	RNF17	31	Q9BXT8
DLSCSRRLSSAHNGG	PKP3	126	Q9Y446
QGSDTSTSRAGRCAR	SLCO2A1	11	Q92959
STSRAGRCARSVFGN	SLCO2A1	16	Q92959
GVTFTSSHCRRDRST	TULP4	56	Q9NRJ4
VSACAGRSAGTRVAR	nan	76	Q8NFD4
CFGGRSRTHRHSGAS	WWP2	186	O00308
GSSCLARHRRTHTGE	ZNF771	186	Q7L3S4
CVVEREASTHSGSRG	ZSCAN5DP	271	P0CG00
CSTGTTRQRRSSGHR	ZP1	546	P60852
EHARGSCFGIRRQNS	PHLPP2	1196	Q6ZVD8
RRSAASQTADGSGCR	RAPGEF1	461	Q13905
CSRSSSALHRIIGGT	TMPRSS7	596	Q7RTY8
GSSCVGPARSHRSCR	PAPLN	61	O95428
GSFGTRDRTCNVTSH	WNT3	291	P56703
THEAQCRRGASTRGS	ZBTB4	251	Q9P1Z0
RTGRSTSSCARAARA	SCAND2P	196	Q9GZW5
CSSVTGVQRRVHEGS	TBC1D4	316	O60343
GTRDRTCNVSSHGID	WNT3A	291	P56704
VCHGSATTREAARGE	TARBP2	336	Q15633
DGDCGTTHSRAARAI	TKFC	401	Q3LXA3
RSQSSRCSRATLFGH	nan	176	Q6ZS46
SLGSNRSNRSHTSGR	ZC3H13	1191	Q5T200
CGRAFRRSSGLSQHR	ZNF358	156	Q9NW07
SLASQTNVGSHCRGR	USP54	521	Q70EL1
CTSHDPQSSRGSRRR	KCNA4	71	P22459
VKRESRSGSTRVCHG	KIAA1958	601	Q8N8K9
HRSRDTCIVISGESG	MYO1G	91	B0I1T2
RSTASYCSRDSRGHN	GRIN2A	1406	Q12879