Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	telomeric DNA binding	APEX1 CTC1 SMG6	8.10e-05	40	42	3	GO:0042162
GeneOntologyMolecularFunction	lipid binding	PACSIN3 DGKB DLC1 CEL RASGRP3 PACSIN2 NLRP3 ASAP1 OSBPL1A	1.74e-04	988	42	9	GO:0008289
GeneOntologyMolecularFunction	GTPase activator activity	ASAP2 DLC1 SMAP2 RASGRP3 ASAP1	2.86e-04	279	42	5	GO:0005096
GeneOntologyMolecularFunction	enzyme activator activity	ASAP2 DLC1 SMAP2 RASGRP3 NLRP3 ASAP1 DBNL	3.96e-04	656	42	7	GO:0008047
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ARFGEF3 ASAP2 DLC1 SMAP2 RASGRP3 ASAP1	6.28e-04	507	42	6	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	ARFGEF3 ASAP2 DLC1 SMAP2 RASGRP3 ASAP1	6.28e-04	507	42	6	GO:0030695
GeneOntologyMolecularFunction	cadherin binding	CTNND1 PACSIN2 PKP4 ASAP1 DBNL	6.96e-04	339	42	5	GO:0045296
GeneOntologyBiologicalProcess	plasma membrane tubulation	PACSIN3 PACSIN2 ASAP1	8.74e-06	20	42	3	GO:0097320
Domain	SH3	PACSIN3 MAP3K9 ASAP2 PACSIN2 ASAP1 DBNL	1.09e-05	216	44	6	PS50002
Domain	SH3	PACSIN3 MAP3K9 ASAP2 PACSIN2 ASAP1 DBNL	1.09e-05	216	44	6	SM00326
Domain	SH3_domain	PACSIN3 MAP3K9 ASAP2 PACSIN2 ASAP1 DBNL	1.21e-05	220	44	6	IPR001452
Domain	SH3_9	PACSIN3 MAP3K9 ASAP2 DBNL	3.37e-05	78	44	4	PF14604
Domain	SH3_1	PACSIN3 ASAP2 PACSIN2 ASAP1 DBNL	4.04e-05	164	44	5	PF00018
Domain	ArfGap	ASAP2 SMAP2 ASAP1	4.27e-05	29	44	3	SM00105
Domain	ARFGAP	ASAP2 SMAP2 ASAP1	4.27e-05	29	44	3	PS50115
Domain	ArfGAP	ASAP2 SMAP2 ASAP1	4.27e-05	29	44	3	IPR001164
Domain	ArfGap	ASAP2 SMAP2 ASAP1	4.27e-05	29	44	3	PF01412
Domain	Plakophilin/d_Catenin	CTNND1 PKP4	1.13e-04	7	44	2	IPR028435
Domain	FCH	PACSIN3 PACSIN2	1.22e-03	22	44	2	PF00611
Domain	FCH	PACSIN3 PACSIN2	1.22e-03	22	44	2	SM00055
Domain	FCH_dom	PACSIN3 PACSIN2	1.33e-03	23	44	2	IPR001060
Domain	F_BAR	PACSIN3 PACSIN2	1.57e-03	25	44	2	IPR031160
Domain	F_BAR	PACSIN3 PACSIN2	1.57e-03	25	44	2	PS51741
Domain	Ank_2	ANKRD30A ASAP2 ASAP1 OSBPL1A	1.62e-03	215	44	4	PF12796
Domain	Ank	ANKRD30A ASAP2 ASAP1 OSBPL1A	2.00e-03	228	44	4	PF00023
Domain	-	ASAP2 ASAP1	2.26e-03	30	44	2	1.20.1270.60
Domain	AH/BAR-dom	ASAP2 ASAP1	2.26e-03	30	44	2	IPR027267
Domain	Arm	CTNND1 PKP4	2.42e-03	31	44	2	PF00514
Domain	-	ANKRD30A ASAP2 ASAP1 OSBPL1A	2.72e-03	248	44	4	1.25.40.20
Domain	ANK	ANKRD30A ASAP2 ASAP1 OSBPL1A	2.84e-03	251	44	4	SM00248
Domain	ANK_REPEAT	ANKRD30A ASAP2 ASAP1 OSBPL1A	2.92e-03	253	44	4	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD30A ASAP2 ASAP1 OSBPL1A	2.96e-03	254	44	4	IPR020683
Domain	ANK_REP_REGION	ANKRD30A ASAP2 ASAP1 OSBPL1A	2.96e-03	254	44	4	PS50297
Domain	Ankyrin_rpt	ANKRD30A ASAP2 ASAP1 OSBPL1A	3.31e-03	262	44	4	IPR002110
Domain	ARM	CTNND1 PKP4	4.00e-03	40	44	2	SM00185
Domain	ARM_REPEAT	CTNND1 PKP4	4.00e-03	40	44	2	PS50176
Domain	Armadillo	CTNND1 PKP4	5.48e-03	47	44	2	IPR000225
Pubmed	Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.	PACSIN3 ASAP2 ASAP1	1.13e-07	8	45	3	15719014
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	PRXL2A CTNND1 SYF2 SMAP2 GPAT4 PKP4 AKAP12 DBNL KNOP1 SEC16A	5.03e-07	1007	45	10	34597346
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ARFGEF3 MARVELD2 CTNND1 STON1 SMAP2 RPS3A AKAP12 KNOP1 SEC16A	5.71e-07	777	45	9	35844135
Pubmed	Protective role of p120-catenin on mitochondria by inhibiting NLRP3 in ventilator-induced lung injury.	CTNND1 NLRP3	1.64e-06	2	45	2	31507096
Pubmed	The syndapin protein family: linking membrane trafficking with the cytoskeleton.	PACSIN3 PACSIN2	1.64e-06	2	45	2	15226389
Pubmed	Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin.	CTNND1 PKP4	1.64e-06	2	45	2	17264675
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ASAP2 DLC1 CTNND1 PACSIN2 PKP4 ASAP1 DBNL KNOP1 SEC16A	2.22e-06	916	45	9	32203420
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	ARFGEF3 MARVELD2 CTNND1 GPAT4 AKAP12 OSBPL1A SEC16A	3.63e-06	504	45	7	34432599
Pubmed	PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages.	IRF8 NLRP3	4.91e-06	3	45	2	33897697
Pubmed	IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death.	IRF8 NLRP3	4.91e-06	3	45	2	32205422
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MAP3K9 URB1 CTC1 PACSIN2 AKAP12 ASAP1 DBNL KNOP1 SEC16A	8.67e-06	1084	45	9	11544199
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	PACSIN3 PACSIN2 ASAP1	8.87e-06	31	45	3	19041431
Pubmed	PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.	PACSIN3 PACSIN2	9.81e-06	4	45	2	11179684
Pubmed	The armadillo protein p0071 regulates Rho signalling during cytokinesis.	CTNND1 PKP4	9.81e-06	4	45	2	17115030
Pubmed	PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.	PACSIN3 PACSIN2	9.81e-06	4	45	2	16627472
Pubmed	Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.	ASAP2 ASAP1	9.81e-06	4	45	2	12149250
Pubmed	Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting.	PACSIN3 PACSIN2	9.81e-06	4	45	2	21610094
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	HTATSF1 URB1 MARVELD2 CTNND1 SMAP2 RPS3A GPAT4 PACSIN2 PKP4 AKAP12	1.61e-05	1487	45	10	33957083
Pubmed	BC-1215 inhibits ATP-induced IL-1β secretion via the FBXL2-mediated ubiquitination and degradation of not only NLRP3, but also pro-IL-1β in LPS-primed THP-1 cells.	NLRP3 RBX1	1.63e-05	5	45	2	37004285
Pubmed	PACSIN proteins bind tubulin and promote microtubule assembly.	PACSIN3 PACSIN2	2.45e-05	6	45	2	18456257
Pubmed	Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.	ASAP2 ASAP1	2.45e-05	6	45	2	18786926
Pubmed	All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.	PACSIN3 PACSIN2	2.45e-05	6	45	2	11082044
Pubmed	PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression.	PACSIN3 PACSIN2	2.45e-05	6	45	2	23918399
Pubmed	Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation.	NLRP3 RBX1	3.42e-05	7	45	2	30653357
Pubmed	ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.	ASAP2 ASAP1	3.42e-05	7	45	2	9819391
Pubmed	DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.	CTNND1 PKP4	3.42e-05	7	45	2	25009281
Pubmed	CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.	ASAP2 ASAP1	3.42e-05	7	45	2	17255943
Pubmed	Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL.	PACSIN3 PACSIN2	4.56e-05	8	45	2	16318909
Pubmed	Examining the specificity of Src homology 3 domain--ligand interactions with alkaline phosphatase fusion proteins.	ASAP1 DBNL	4.56e-05	8	45	2	9126384
Pubmed	The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF.	CTNND1 PKP4	4.56e-05	8	45	2	11821434
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	MARVELD2 CTNND1 PACSIN2 PKP4 ASAP1 DBNL	8.51e-05	565	45	6	25468996
Pubmed	Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family.	ASAP2 ASAP1	1.07e-04	12	45	2	35192416
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAP3K9 ARFGEF3 DLC1 CTNND1 SMAP2 DBNL SEC16A	1.11e-04	861	45	7	36931259
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	PACSIN3 CTNND1 PACSIN2 PKP4 AKAP12	1.25e-04	377	45	5	38117590
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	MARVELD2 CTNND1 PKP4	1.28e-04	75	45	3	15951569
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ARFGEF3 CTNND1 STON1 SEC16A	1.56e-04	209	45	4	36779422
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	URB1 CTNND1 B3GNT2 PKP4 RBX1 OSBPL1A SEC16A	1.70e-04	922	45	7	27609421
Pubmed	Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).	PACSIN3 PACSIN2	1.70e-04	15	45	2	25036101
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	HTATSF1 CTNND1 RPS3A AKAP12 DBNL KNOP1 SEC16A	1.84e-04	934	45	7	33916271
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	ASAP2 CTNND1 RPS3A ASAP1 RBX1 SEC16A	1.90e-04	655	45	6	35819319
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	PRXL2A MARVELD2 CTNND1 GPAT4 PKP4 AKAP12 SEC16A	2.06e-04	952	45	7	38569033
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PACSIN3 CTNND1 PKP4 AKAP12 SEC16A	2.08e-04	421	45	5	36976175
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	PACSIN3 DGKB HTATSF1 ASAP2 RPS3A RASGRP3 RBX1 DBNL	2.16e-04	1284	45	8	17353931
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	PACSIN3 AEBP1 PACSIN2 SEC16A	2.24e-04	230	45	4	35449600
Pubmed	Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.	IRF8 B3GNT2	2.47e-04	18	45	2	22446963
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	PACSIN3 CTNND1 RPS3A PKP4 DBNL KNOP1	2.80e-04	704	45	6	32994395
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	PACSIN3 MARVELD2 CTNND1 PACSIN2 PKP4 AKAP12	3.13e-04	719	45	6	35337019
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	PRXL2A MARVELD2 CTNND1 PKP4 AKAP12	3.35e-04	467	45	5	30194290
Pubmed	Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.	CTNND1 AKAP12 DBNL	3.56e-04	106	45	3	38891874
Pubmed	p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas.	CTNND1 PKP4	4.07e-04	23	45	2	25523391
Pubmed	IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.	IRF8 NLRP3	4.07e-04	23	45	2	29576451
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DGKB PDE1C CTNND1 RPS3A PKP4 ASAP1 DBNL SEC16A	4.46e-04	1431	45	8	37142655
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	MAP3K9 ASAP2 PKP4 ASAP1	4.79e-04	281	45	4	28706196
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	HTATSF1 APEX1 RPS3A PACSIN2 AKAP12 RBX1 DBNL SEC16A	4.99e-04	1455	45	8	22863883
Pubmed	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.	ASAP2 ASAP1	5.63e-04	27	45	2	18685082
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PACSIN3 APEX1 URB1 COX16 PKP4 DBNL KNOP1 SMG6	6.01e-04	1497	45	8	31527615
Pubmed	The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.	CTNND1 DBNL	6.50e-04	29	45	2	19208628
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	PACSIN3 URB1 CTNND1 SYF2 RPS3A KNOP1	7.43e-04	847	45	6	35850772
Pubmed	The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.	SLC17A6 SEC16A	7.43e-04	31	45	2	29099309
Pubmed	Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.	HTATSF1 CTNND1 RPS3A PACSIN2 DBNL	7.51e-04	558	45	5	35063084
Pubmed	Accessory subunits are integral for assembly and function of human mitochondrial complex I.	NDUFA11 DMAC2	7.92e-04	32	45	2	27626371
Pubmed	Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.	APEX1 CTNND1 RPS3A DBNL	8.44e-04	327	45	4	15592455
Pubmed	Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.	PACSIN3 APEX1 PACSIN2 DBNL	8.73e-04	330	45	4	21044950
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	URB1 CTNND1 RPS3A GPAT4 NDUFA11 RBX1 SEC16A	1.08e-03	1257	45	7	37317656
Cytoband	14q24.2	MAP3K9 COX16	2.78e-04	25	45	2	14q24.2
Cytoband	7p13	AEBP1 DBNL	6.80e-04	39	45	2	7p13
Cytoband	Ensembl 112 genes in cytogenetic band chr7p13	AEBP1 DBNL	1.25e-03	53	45	2	chr7p13
Cytoband	9q34.3	CEL SEC16A	4.90e-03	106	45	2	9q34.3
GeneFamily	ArfGAPs	ASAP2 SMAP2 ASAP1	1.96e-05	33	29	3	395
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ASAP2 ASAP1	3.33e-04	17	29	2	1291
GeneFamily	Ankyrin repeat domain containing	ANKRD30A ASAP2 ASAP1 OSBPL1A	5.72e-04	242	29	4	403
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	PACSIN3 PACSIN2	6.15e-04	23	29	2	1288
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CTNND1 PKP4	2.15e-03	43	29	2	409
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3\|TCGA-Skin / Sample_Type by Project: Shred V9	DLC1 STON1 ASAP1 KNOP1 OSBPL1A	5.64e-07	159	45	5	fb222c42f66901852b01cec073ec0732245ee973
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	PRXL2A DGKB PDE1C DLC1 PACSIN2	1.16e-06	184	45	5	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	DGKB PDE1C DLC1 PACSIN2 ASAP1	1.19e-06	185	45	5	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C ASAP2 CTNND1 RASGRP3 PKP4	1.47e-06	193	45	5	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C ASAP2 CTNND1 RASGRP3 PKP4	1.47e-06	193	45	5	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis	IRF8 AEBP1 SMAP2 RPS3A AKAP12	1.50e-06	194	45	5	4199900d16623eca02d674d5ada7f0989e47955e
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C ASAP2 CTNND1 RASGRP3 PKP4	1.50e-06	194	45	5	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASAP2 DLC1 CTNND1 RASGRP3 PKP4	1.50e-06	194	45	5	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C ASAP2 CTNND1 RASGRP3 PKP4	1.50e-06	194	45	5	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IRF8 APEX1 RPS3A DMAC2	1.59e-05	150	45	4	d6b977dd47aa017f6ba762f0c505cd896caa523f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STON1 AEBP1 AKAP12 ISM1	1.85e-05	156	45	4	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STON1 AEBP1 AKAP12 ISM1	1.85e-05	156	45	4	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	severe_influenza-CD4+_T_naive\|severe_influenza / disease group, cell group and cell class (v2)	STMND1 AEBP1 RPS3A ISM1	1.95e-05	158	45	4	ff3fa4bd06e01363429aec4bb587b95819bf0fc9
ToppCell	10x5'-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	DLC1 CEL GPAT4 AKAP12	2.00e-05	159	45	4	c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCell	10x5'-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	DLC1 CEL GPAT4 AKAP12	2.10e-05	161	45	4	15ba7e69699558353cfeecdcf1dbc2e147379ed6
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	DGKB DLC1 PACSIN2 AKAP12	2.10e-05	161	45	4	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A DGKB PDE1C ASAP2	2.97e-05	176	45	4	6c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A DGKB PDE1C ASAP2	3.11e-05	178	45	4	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD30A DGKB PDE1C ASAP2	3.25e-05	180	45	4	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	PDE1C DLC1 PACSIN2 ASAP1	3.32e-05	181	45	4	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	PDE1C DLC1 PACSIN2 ASAP1	3.39e-05	182	45	4	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	LA-07._Pericyte\|World / Chamber and Cluster_Paper	DGKB PDE1C DLC1 PACSIN2	3.46e-05	183	45	4	e3835db4795362b0442d5893baf2a78efcc20428
ToppCell	LV-07._Pericyte\|World / Chamber and Cluster_Paper	DGKB PDE1C DLC1 PACSIN2	3.46e-05	183	45	4	273db6a3b00a93ca852498471187b642b5368185
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 DGKB PDE1C HYDIN	3.54e-05	184	45	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 DGKB PDE1C HYDIN	3.54e-05	184	45	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 DGKB PDE1C HYDIN	3.54e-05	184	45	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LV-07._Pericyte\|LV / Chamber and Cluster_Paper	DGKB PDE1C DLC1 PACSIN2	3.61e-05	185	45	4	acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARFGEF3 STMND1 HYDIN DBNL	3.69e-05	186	45	4	02fbb02c495e7d64c4ab50e42e5197782f2c0816
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	DGKB PDE1C DLC1 PACSIN2	3.69e-05	186	45	4	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASAP2 DLC1 RASGRP3 AKAP12	3.77e-05	187	45	4	52ffd4be374e329ac8d321063f061b826d252956
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	DGKB PDE1C DLC1 PACSIN2	3.77e-05	187	45	4	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	STON1 AEBP1 AKAP12 ISM1	3.85e-05	188	45	4	8231e635706a296db6b6da1029a33bbc1b52478e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE1C STMND1 CEL HYDIN	3.93e-05	189	45	4	cd4746ea6ae48a7dd14a2960d38d9445a738cf2c
ToppCell	droplet-Lung-LUNG-30m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASAP2 DLC1 RASGRP3 AKAP12	3.93e-05	189	45	4	25db316f66cee53774bb2b286cc457b37353356c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	URB1 AEBP1 AKAP12 ASAP1	4.01e-05	190	45	4	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	URB1 AEBP1 AKAP12 ASAP1	4.01e-05	190	45	4	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	B_cell_maturation\|World / Lineage and Cell class	IRF8 AEBP1 RASGRP3 AKAP12	4.01e-05	190	45	4	301782283d0c604fb3b428a8ddf1f7cd8e63a90b
ToppCell	BLOOD--(3)_MNP-(3)_DC_(cDC+pDC)\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	IRF8 PRXL2A APEX1 AEBP1	4.01e-05	190	45	4	9b8de47f7a2e6137d934ccce32417ab15eb54f46
ToppCell	droplet-Lung-LUNG-30m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASAP2 DLC1 RASGRP3 AKAP12	4.01e-05	190	45	4	e64b191f928935484e2c993d7f8af0572a617a3a
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PDE1C DLC1 CTNND1 PKP4	4.09e-05	191	45	4	a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASAP2 CTNND1 RASGRP3 PKP4	4.26e-05	193	45	4	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ASAP2 CTNND1 RASGRP3 PKP4	4.26e-05	193	45	4	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	EC-Sinusoidal_ECs\|EC / Lineage and Cell class	IRF8 DLC1 AEBP1 SMAP2	4.26e-05	193	45	4	1291b1d3494dcb4b9309f8bff63fb662e7eca0c8
ToppCell	severe_influenza-B_naive\|World / disease group, cell group and cell class (v2)	IRF8 SMAP2 RPS3A RASGRP3	4.26e-05	193	45	4	c52ba94782ad57b93d20f853a89344dffa8351f9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 RASGRP3 ASAP1 ISM1	4.26e-05	193	45	4	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 AEBP1 AKAP12 ASAP1	4.35e-05	194	45	4	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 AEBP1 AKAP12 ASAP1	4.35e-05	194	45	4	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	(4)_Endothelial_cells-(42)_EC-sinusoidal\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	IRF8 SMAP2 RASGRP3 AKAP12	4.35e-05	194	45	4	4428b472c2042f88eae028b1770767512a515b75
ToppCell	COPD-Endothelial-Lymphatic\|Endothelial / Disease state, Lineage and Cell class	IRF8 PRXL2A RASGRP3 AKAP12	4.44e-05	195	45	4	e91ce548ae7224661ee5d2f2639794a5f69798ee
ToppCell	ASK440-Endothelial-Lymphatic\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	PRXL2A RPS3A AKAP12 RBX1	4.53e-05	196	45	4	833723c8753922374cd7730907f1596899dd5734
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 AEBP1 AKAP12 ASAP1	4.62e-05	197	45	4	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 AEBP1 AKAP12 ASAP1	4.71e-05	198	45	4	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	metastatic_Brain-Fibroblasts-Pericytes\|Fibroblasts / Location, Cell class and cell subclass	PRXL2A DLC1 PACSIN2 B3GNT2	4.71e-05	198	45	4	86a4c8e859ce11a95875f8844963baeb1ba898ec
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE1C DLC1 STON1 AKAP12	4.71e-05	198	45	4	b7e900fc0a1b3fa5e47dcc36ce6b0c3ce6bf9739
ToppCell	Parenchymal-NucSeq-Endothelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE1C RASGRP3 AKAP12 ASAP1	4.80e-05	199	45	4	a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARFGEF3 PDE1C DLC1 DNAH17	4.80e-05	199	45	4	5d2e85e40b6b52b1809e680b952913d77215b3d0
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARFGEF3 PDE1C DLC1 DNAH17	4.80e-05	199	45	4	9dd4b17fb8c70ab9e126b23b72600463f3db832d
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARFGEF3 PDE1C DLC1 DNAH17	4.80e-05	199	45	4	6fb5f931e6217142de38c1fffc011e63bda4772b
ToppCell	10x_5'_v1-Non-neoplastic-Glial-Neuronal\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ARFGEF3 PDE1C DLC1 DNAH17	4.80e-05	199	45	4	1bb5797e8e0552bf9b44bf4c958d1aa6dbe6c756
ToppCell	Sepsis-Bac-SEP-Myeloid-pDC\|Bac-SEP / Disease, condition lineage and cell class	IRF8 PRXL2A AEBP1 RPS3A	4.80e-05	199	45	4	7f6569de050262f3d8d9d41c0f0cc139de85c0cb
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 CTNND1 PKP4	4.89e-05	200	45	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 CTNND1 PKP4	4.89e-05	200	45	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 CTNND1 PKP4	4.89e-05	200	45	4	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 CTNND1 PKP4	4.89e-05	200	45	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE1C DLC1 AEBP1 ISM1	4.89e-05	200	45	4	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 CTNND1 PKP4	4.89e-05	200	45	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLC1 AEBP1 AKAP12 ISM1	4.89e-05	200	45	4	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ASAP2 DLC1 CTNND1 PKP4	4.89e-05	200	45	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLC1 AEBP1 AKAP12 ISM1	4.89e-05	200	45	4	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLC1 AEBP1 AKAP12 ISM1	4.89e-05	200	45	4	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	STON1 HYDIN SLC17A6	9.03e-05	86	45	3	2990429ed4438f41ff03f4a9cae8863a528fdd81
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-CR\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	STON1 HYDIN SLC17A6	9.03e-05	86	45	3	97467708c90a4bd49deafe3e2ec495c56b448ce1
ToppCell	TCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-3\|TCGA-Skin / Sample_Type by Project: Shred V9	STON1 ASAP1 OSBPL1A	1.50e-04	102	45	3	57a30ef6ac6ee623bb328b945a9d7c9a56d40a4e
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	STMND1 HYDIN DNAH17	1.63e-04	105	45	3	76b73bc9236030e0703868fa8f7ecee2affe565b
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	STMND1 HYDIN DNAH17	1.63e-04	105	45	3	bfd3395c51a0e868aa92eac4e929de59a3fe8b50
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Myoc_(Myoc)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	STMND1 HYDIN DNAH17	1.63e-04	105	45	3	96566c83999aa625c84a4ed18a6df9daa99f9578
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IRF8 PDE1C STMND1	3.13e-04	131	45	3	d706405453408fbcfcabb1c7702b80f9e649ffca
ToppCell	10x5'-blood-Lymphocytic_T_CD8-Trm_gut_CD8\|blood / Manually curated celltypes from each tissue	PRXL2A RASGRP3 AKAP12	5.02e-04	154	45	3	c77a02df403358361aca86c679d5c43a64ff2f7f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 AEBP1 AKAP12	5.21e-04	156	45	3	d5207dbfbcfb885557ea1378dfe6a56d7102e94a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 AEBP1 AKAP12	5.21e-04	156	45	3	363f1b661048d25895e2b8681c82894c957b29c0
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Mes-Epi-like\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 MARVELD2 OSBPL1A	5.31e-04	157	45	3	bd45590da540a557dc8096980a45220fccb99505
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARFGEF3 MARVELD2 OSBPL1A	5.31e-04	157	45	3	00c9a58b033b8b95b0d838f233dd077b62d8b02a
ToppCell	IPF-Epithelial-Ionocyte\|Epithelial / Disease state, Lineage and Cell class	PDE1C CEL B3GNT2	5.41e-04	158	45	3	67adf625a959444762d32268b3b7441f6f8b3b8c
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DLC1 AEBP1 AKAP12	5.61e-04	160	45	3	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	DGKB DLC1 PACSIN2	5.61e-04	160	45	3	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	COVID_non-vent-Lymphocytic-Dendritic-pDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IRF8 PRXL2A AEBP1	5.61e-04	160	45	3	61f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCell	NS-critical-d_16-33-Myeloid-Mast_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DLC1 AEBP1 AKAP12	5.61e-04	160	45	3	c61869d9dbba250270e59366e15af204e5b4395d
ToppCell	COVID_non-vent-Lymphocytic-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	IRF8 PRXL2A AEBP1	5.61e-04	160	45	3	34b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell	Severe-B_naive-11\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	IRF8 SMAP2 RPS3A	5.72e-04	161	45	3	ad3b58e3a8b59a609c8d2d2690d15218d18eabbd
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-DC1\|bone_marrow / Manually curated celltypes from each tissue	IRF8 HYDIN ASAP1	5.72e-04	161	45	3	2f068ee643de2f647c289779a6624265ab9a749b
ToppCell	lymphoid-B_cell-pro-B\|World / Lineage, cell class and subclass	PRXL2A AEBP1 AKAP12	5.72e-04	161	45	3	23138e579f07d5a6f20d41457cb573b4ac95a4ef
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 AEBP1 AKAP12	5.82e-04	162	45	3	5f009b231f21861afee9cc0c569082e1135f929c
ToppCell	facs-Heart-RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PACSIN3 PDE1C NLRP3	5.82e-04	162	45	3	3a61eda548afa2a41bdf6293d1050103dc210e52
ToppCell	facs-Heart-RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PACSIN3 PDE1C NLRP3	5.82e-04	162	45	3	593939be9d38690c89c31d4c58e351de26cbf9ab
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DLC1 AEBP1 AKAP12	5.82e-04	162	45	3	b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRP3 ASAP1 SLC17A6	5.82e-04	162	45	3	5428c9fdb816f564395ebb4520448e5f3a42b025
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	STMND1 MARVELD2 HYDIN	6.14e-04	165	45	3	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1C DLC1 ASAP1	6.14e-04	165	45	3	4f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCell	Ionocyte\|World / shred by cell class for turbinate	PDE1C CEL B3GNT2	6.14e-04	165	45	3	0cb2199b87f17ece743fb2652b2f448dfa78ae0b
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-CD4_Naive\|ICU-NoSEP / Disease, Lineage and Cell Type	DGKB RPS3A ISM1	6.14e-04	165	45	3	3d2f6f91a5eee64d01366f35d2cc3cf9ac37ac16
Disease	anemia (phenotype), response to ribavirin	RASGRP3 DNAH17	7.77e-05	9	44	2	EFO_0004272, GO_1901559
Disease	n-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 measurement	B3GNT2 DMAC2	7.77e-05	9	44	2	EFO_0801817
Disease	squamous cell carcinoma, esophageal carcinoma	APEX1 SMG6	9.71e-05	10	44	2	EFO_0000707, EFO_0002916
Disease	coronary artery disease	PDE1C ASAP2 DLC1 STON1 CEL B3GNT2 AKAP12 SMG6	3.40e-04	1194	44	8	EFO_0001645
Disease	nevus count, cutaneous melanoma	STON1 AKAP12 ASAP1	3.43e-04	91	44	3	EFO_0000389, EFO_0004632
Disease	reasoning	MAP3K9 PDE1C	3.66e-04	19	44	2	EFO_0004350
Disease	FEV/FEC ratio	PRXL2A DGKB PDE1C ASAP2 DLC1 RASGRP3 ASAP1 SMG6	4.10e-04	1228	44	8	EFO_0004713
Disease	haptoglobin measurement	DLC1 HYDIN	4.48e-04	21	44	2	EFO_0004640
Disease	chronic obstructive pulmonary disease	DGKB ASAP2 DLC1 STON1 RASGRP3 SMG6	5.22e-04	688	44	6	EFO_0000341
Disease	total blood protein measurement	STON1 HYDIN RASGRP3 SMG6 SEC16A	5.32e-04	449	44	5	EFO_0004536
Disease	stimulant use measurement	DLC1 ASAP1	8.01e-04	28	44	2	EFO_0600076
Disease	Huntington's disease (implicated_via_orthology)	PACSIN3 PACSIN2	1.05e-03	32	44	2	DOID:12858 (implicated_via_orthology)
Disease	balding measurement	DLC1 SYF2 AKAP12 ISM1 DMAC2 SMG6	1.09e-03	792	44	6	EFO_0007825
Disease	neurodegenerative disease (implicated_via_orthology)	PACSIN3 PACSIN2 SLC17A6	1.33e-03	145	44	3	DOID:1289 (implicated_via_orthology)
Disease	fibrinogen measurement, coronary artery disease	CEL NLRP3 SMG6	1.58e-03	154	44	3	EFO_0001645, EFO_0004623
Disease	myocardial infarction	DGKB STON1 CEL SMG6	1.82e-03	350	44	4	EFO_0000612
Disease	thyroid peroxidase antibody measurement, anti-thyroglobulin antibody measurement	IRF8 SMG6	2.07e-03	45	44	2	EFO_0005666, EFO_0009896
Disease	Multiple Sclerosis	IRF8 NLRP3	2.07e-03	45	44	2	C0026769
Disease	Multiple Sclerosis, Acute Fulminating	IRF8 NLRP3	2.07e-03	45	44	2	C0751324
Disease	neutrophil count, eosinophil count	IRF8 CEL NLRP3	3.95e-03	213	44	3	EFO_0004833, EFO_0004842
Disease	neutrophil count	IRF8 CEL HYDIN NLRP3 AKAP12 OSBPL1A SMG6	4.08e-03	1382	44	7	EFO_0004833
Disease	Epstein-Barr virus infection	DLC1 SYF2	4.39e-03	66	44	2	EFO_0000769
Disease	magnesium measurement	DLC1 ASAP1	4.39e-03	66	44	2	EFO_0004845

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKKKRTPQEDQWDGV	PKP4	791	Q99569
EEFDLSPDQWRKGKK	SMG6	826	Q86US8
KEEGQRKAWASFDPK	CTC1	556	Q2NKJ3
GWRKKTSFRKPKEDE	AKAP12	306	Q02952
EKKREGVTPWASFKK	AKAP12	601	Q02952
WAVEKGKDHKEPRKG	AEBP1	356	Q8IUX7
AKGRPRKIAWEKKED	ANKRD30A	376	Q9BXX3
GAVKFRDKEWIRPDK	DMAC2	96	Q9NW81
KDSKFDDWKNIRGPR	COX16	71	Q9P0S2
IKKKGLDWVKEEAPD	APEX1	76	P27695
KNPLFWAKKVAEKVG	CEL	251	P19835
KMGRLEGWEVFAKPK	NDUFA11	126	Q86Y39
GAGKKRFEVKKWNAV	RBX1	16	P62877
KGVKGDLKKPFDKAW	ASAP2	136	O43150
ASKREKWIKADAPKG	FAM185A	361	Q8N0U4
KFKEGDKAEPATWKT	IRF8	66	Q02556
WRAKVPKEEKAKKEA	PDE1C	521	Q14123
KKKRKESGVAGDPWK	KNOP1	291	Q1ED39
KLKFWGKSVEAEPKG	OSBPL1A	676	Q9BXW6
ARKKGEKRKAESGWF	HTATSF1	111	O43719
TKEAEDGFRKAQKPW	PACSIN2	131	Q9UNF0
DGFRKAQKPWAKKLK	PACSIN2	136	Q9UNF0
DVGARFKWDIKKFEP	HYDIN	4556	Q4G0P3
KFKPDKWSKLIGAEE	DNAH17	21	Q9UFH2
WDGGLKREKVKDTFK	GPAT4	421	Q86UL3
KKDPSRKKEWWENAG	ARFGEF3	1996	Q5TH69
RWKFEVIPNDKDEKG	DGKB	561	Q9Y6T7
KGVKGDLKKPFDKAW	ASAP1	156	Q9ULH1
WKNFFRGKKKDPEWD	MARVELD2	86	Q8N4S9
IKRKDFRWKDASGPK	ISM1	341	B1AKI9
FRWKDASGPKEKLEI	ISM1	346	B1AKI9
AKKGKDEWFSRGKKP	CTNND1	621	O60716
RKPLEKEGWKKSDFQ	CTNND1	836	O60716
IKRVGKDSFWAKAEK	DBNL	171	Q9UJU6
EEEKRAPKKKGRTWG	MAP3K9	586	P80192
AAEDGFRKAQKPWLK	PACSIN3	131	Q9UKS6
KAKRDEPKWGSDNAR	NLRP3	86	Q96P20
WERKKKRKNPDLGFS	SYF2	111	O95926
GAKKKVVDPFSKKDW	RPS3A	16	P61247
KDKGFAKWENEKPRV	RASGRP3	646	Q8IV61
GLFKEVKEKFKGWVS	DLC1	1331	Q96QB1
DPGDWQKFVKKGLKF	URB1	1426	O60287
PRTFKAKELWEKNGA	PRXL2A	61	Q9BRX8
NGKGEVIIPKEKFWK	B3GNT2	36	Q9NY97
RGGKVIKEKAKFNWD	SLC17A6	106	Q9P2U8
KKETKEPKKGESWFF	SEC16A	2096	O15027
KKWIKIDGEDPDKIG	STON1	716	Q9Y6Q2
NAFRKEKDDKWKRGS	SMAP2	131	Q8WU79
RAPKKGWKEEFKADV	STMND1	16	H3BQB6