Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	pseudopodium	ACTN4 ACTN2 ACTN3	1.37e-05	18	55	3	GO:0031143
GeneOntologyCellularComponent	contractile muscle fiber	RTL1 LRRC27 ACTN4 ACTN2 ACTN3 NPNT	1.11e-04	290	55	6	GO:0043292
GeneOntologyCellularComponent	sarcomere	RTL1 LRRC27 ACTN4 ACTN2 ACTN3	4.93e-04	249	55	5	GO:0030017
GeneOntologyCellularComponent	Z disc	RTL1 ACTN4 ACTN2 ACTN3	6.70e-04	151	55	4	GO:0030018
GeneOntologyCellularComponent	myofibril	RTL1 LRRC27 ACTN4 ACTN2 ACTN3	7.47e-04	273	55	5	GO:0030016
GeneOntologyCellularComponent	I band	RTL1 ACTN4 ACTN2 ACTN3	9.54e-04	166	55	4	GO:0031674
GeneOntologyCellularComponent	postsynaptic actin cytoskeleton	ACTN4 ACTN2	1.13e-03	19	55	2	GO:0098871
GeneOntologyCellularComponent	cortical actin cytoskeleton	ACTN4 ACTN2 ACTN3	1.89e-03	93	55	3	GO:0030864
GeneOntologyCellularComponent	postsynaptic cytoskeleton	ACTN4 ACTN2	2.12e-03	26	55	2	GO:0099571
GeneOntologyCellularComponent	striated muscle thin filament	ACTN2 ACTN3	2.29e-03	27	55	2	GO:0005865
Domain	EF-hand_Ca_insen	ACTN4 ACTN2 ACTN3	5.07e-07	6	56	3	IPR014837
Domain	EFhand_Ca_insen	ACTN4 ACTN2 ACTN3	5.07e-07	6	56	3	PF08726
Domain	CH	ACTN4 LIMCH1 ACTN2 ACTN3	4.28e-05	65	56	4	SM00033
Domain	Actinin_actin-bd_CS	ACTN4 ACTN2 ACTN3	4.33e-05	23	56	3	IPR001589
Domain	Spectrin	ACTN4 ACTN2 ACTN3	4.33e-05	23	56	3	PF00435
Domain	ACTININ_2	ACTN4 ACTN2 ACTN3	4.33e-05	23	56	3	PS00020
Domain	ACTININ_1	ACTN4 ACTN2 ACTN3	4.33e-05	23	56	3	PS00019
Domain	CH	ACTN4 LIMCH1 ACTN2 ACTN3	5.74e-05	70	56	4	PF00307
Domain	-	ACTN4 LIMCH1 ACTN2 ACTN3	6.07e-05	71	56	4	1.10.418.10
Domain	CH	ACTN4 LIMCH1 ACTN2 ACTN3	6.76e-05	73	56	4	PS50021
Domain	CH-domain	ACTN4 LIMCH1 ACTN2 ACTN3	7.52e-05	75	56	4	IPR001715
Domain	Spectrin_repeat	ACTN4 ACTN2 ACTN3	8.83e-05	29	56	3	IPR002017
Domain	Spectrin/alpha-actinin	ACTN4 ACTN2 ACTN3	1.19e-04	32	56	3	IPR018159
Domain	SPEC	ACTN4 ACTN2 ACTN3	1.19e-04	32	56	3	SM00150
Domain	IBN_N	IPO8 XPO5	1.03e-03	16	56	2	SM00913
Domain	EF-hand_1	ACTN4 ACTN2 ACTN3 PPEF1	1.11e-03	152	56	4	PF00036
Domain	Importin-beta_N	IPO8 XPO5	1.17e-03	17	56	2	IPR001494
Domain	EFh	ACTN4 ACTN2 ACTN3 PPEF1	1.29e-03	158	56	4	SM00054
Domain	EGF_CA	NOTCH2NLA NOTCH2NLC NPNT	2.19e-03	86	56	3	PF07645
Domain	EGF_Ca-bd_CS	NOTCH2NLA NOTCH2NLC NPNT	3.08e-03	97	56	3	IPR018097
Domain	EGF_CA	NOTCH2NLA NOTCH2NLC NPNT	3.27e-03	99	56	3	PS01187
Domain	ASX_HYDROXYL	NOTCH2NLA NOTCH2NLC NPNT	3.36e-03	100	56	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	NOTCH2NLA NOTCH2NLC NPNT	3.96e-03	106	56	3	IPR000152
Domain	EF_HAND_2	ACTN4 ACTN2 ACTN3 PPEF1	5.06e-03	231	56	4	PS50222
Domain	EF_hand_dom	ACTN4 ACTN2 ACTN3 PPEF1	5.14e-03	232	56	4	IPR002048
Domain	EGF_CA	NOTCH2NLA NOTCH2NLC NPNT	5.86e-03	122	56	3	SM00179
Domain	EGF-like_Ca-bd_dom	NOTCH2NLA NOTCH2NLC NPNT	6.13e-03	124	56	3	IPR001881
Domain	-	ZC3H13 DUS3L	6.40e-03	40	56	2	4.10.1000.10
Domain	-	ACTN4 ACTN2 ACTN3 PPEF1	7.75e-03	261	56	4	1.10.238.10
Domain	ubiquitin	SACS OASL	8.75e-03	47	56	2	PF00240
Pathway	REACTOME_NEPHRIN_FAMILY_INTERACTIONS	ACTN4 ACTN2 ACTN3	3.60e-05	23	40	3	M913
Pubmed	The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.	ACTN4 ACTN2 ACTN3	3.95e-09	3	56	3	10656685
Pubmed	Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.	ACTN4 ACTN2 ACTN3	3.95e-09	3	56	3	8104223
Pubmed	Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.	ACTN4 ACTN2 ACTN3	1.58e-08	4	56	3	1629252
Pubmed	Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.	ACTN4 ACTN2 ACTN3	1.58e-08	4	56	3	16807302
Pubmed	Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.	ACTN4 ACTN2 ACTN3	3.94e-08	5	56	3	15841212
Pubmed	The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.	ACTN4 ACTN2 ACTN3	3.94e-08	5	56	3	12837758
Pubmed	Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.	ACTN4 ACTN2 ACTN3	3.94e-08	5	56	3	19943616
Pubmed	Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.	ACTN4 ACTN2 ACTN3	7.88e-08	6	56	3	18425115
Pubmed	The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.	ACTN4 ACTN2 ACTN3	7.88e-08	6	56	3	22693585
Pubmed	Mice deficient in alpha-actinin-4 have severe glomerular disease.	ACTN4 ACTN2 ACTN3	2.20e-07	8	56	3	12782671
Pubmed	CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.	ACTN4 ACTN2 ACTN3	2.20e-07	8	56	3	20215401
Pubmed	Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.	ACTN4 ACTN2 ACTN3	4.71e-07	10	56	3	20368620
Pubmed	Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.	ACTN4 ACTN2 ACTN3	8.61e-07	12	56	3	15465019
Pubmed	Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.	ACTN4 ACTN2 ACTN3	1.77e-06	15	56	3	11440986
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ADAMTS12 STARD13 AHCYL1 SACS CEBPZ ACTN4 LIMCH1 ACTN2 ACTN3 PFKM SLC4A3 CUX1	2.53e-06	1442	56	12	35575683
Pubmed	Human skeletal muscle-specific alpha-actinin-2 and -3 isoforms form homodimers and heterodimers in vitro and in vivo.	ACTN2 ACTN3	2.55e-06	2	56	2	9675099
Pubmed	Tumor suppressor pRB functions as a co-repressor of the CCAAT displacement protein (CDP/cut) to regulate cell cycle controlled histone H4 transcription.	RB1 CUX1	2.55e-06	2	56	2	12891711
Pubmed	Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.	ACTN2 ACTN3	2.55e-06	2	56	2	19150855
Pubmed	The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.	STARD13 KIF1B	2.55e-06	2	56	2	25518808
Pubmed	α-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms.	ACTN2 ACTN3	2.55e-06	2	56	2	22253474
Pubmed	alpha-actinin-3 and performance.	ACTN2 ACTN3	2.55e-06	2	56	2	19696509
Pubmed	Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes.	ACTN2 ACTN3	2.55e-06	2	56	2	32451822
Pubmed	Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11.	ACTN2 ACTN3	2.55e-06	2	56	2	1339456
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTLL12 NDST1 AHCYL1 SACS KIF1B ACTN4 CABIN1 TUBGCP5 CFAP298 SLC4A3 CUX1	5.42e-06	1285	56	11	35914814
Pubmed	α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.	ACTN4 ACTN3	7.63e-06	3	56	2	21784188
Pubmed	Colocalization of α-actinin and synaptopodin in the pyramidal cell axon initial segment.	ACTN4 ACTN2	7.63e-06	3	56	2	21940706
Pubmed	Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.	ACTN4 ACTN2 ACTN3	1.13e-05	27	56	3	36899856
Pubmed	Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.	NOTCH2NLA NOTCH2NLC	1.52e-05	4	56	2	29561261
Pubmed	Brain-specific regulator of G-protein signaling 9-2 selectively interacts with alpha-actinin-2 to regulate calcium-dependent inactivation of NMDA receptors.	ACTN4 ACTN2	1.52e-05	4	56	2	16510730
Pubmed	Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.	NOTCH2NLA NOTCH2NLC	1.52e-05	4	56	2	32330268
Pubmed	Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.	NOTCH2NLA NOTCH2NLC	2.54e-05	5	56	2	29856954
Pubmed	Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.	NOTCH2NLA NOTCH2NLC	2.54e-05	5	56	2	29856955
Pubmed	Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.	ACTN2 ACTN3	2.54e-05	5	56	2	9268580
Pubmed	Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling.	ACTN2 ACTN3	2.54e-05	5	56	2	21536590
Pubmed	p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis.	ACTN2 ACTN3	2.54e-05	5	56	2	9438383
Pubmed	Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.	ACTN2 ACTN3	2.54e-05	5	56	2	11171996
Pubmed	Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.	IGBP1 ACTN4	3.80e-05	6	56	2	17438131
Pubmed	Dual functions of Dab1 during brain development.	CUX1 CRK	5.32e-05	7	56	2	18981215
Pubmed	Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.	ACTN4 ACTN2	5.32e-05	7	56	2	11724819
Pubmed	Gene defect in ectodermal dysplasia implicates a death domain adapter in development.	EDARADD ACTN2	5.32e-05	7	56	2	11780064
Pubmed	Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes.	RTL1 ACTN2	7.09e-05	8	56	2	32878913
Pubmed	Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.	ACTN2 ACTN3	7.09e-05	8	56	2	11309420
Pubmed	The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.	ACTN2 ACTN3	7.09e-05	8	56	2	11381084
Pubmed	The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.	ACTN2 ACTN3	7.09e-05	8	56	2	18687124
Pubmed	The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.	EPS8L1 ACTN2	7.09e-05	8	56	2	14565974
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TTLL12 XPO5 CEBPZ PREP ZC3H13 OASL ACTN4	8.32e-05	653	56	7	22586326
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	IPO8 XPO5 CEBPZ OASL RNF213 LIMCH1 PFKM CABIN1 CUX1 LCLAT1	8.98e-05	1440	56	10	30833792
Pubmed	Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.	ACTN2 ACTN3	9.10e-05	9	56	2	11114196
Pubmed	GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.	LIMCH1 PFKM	1.14e-04	10	56	2	25199915
Pubmed	Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.	CUX1 SMAD5	1.39e-04	11	56	2	27680501
Pubmed	Generation of the primary hair follicle pattern.	EDARADD SMAD5	1.39e-04	11	56	2	16769906
Pubmed	Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.	ACTN2 ACTN3	1.39e-04	11	56	2	16585392
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	NDST1 AHCYL1 IPO8 XPO5 OASL POMT1 LCLAT1	1.51e-04	719	56	7	35337019
Pubmed	The DNA sequence and analysis of human chromosome 13.	STARD13 RB1 SACS ZC3H13	1.66e-04	170	56	4	15057823
Pubmed	Molecular diversity of myofibrillar proteins: gene regulation and functional significance.	ACTN2 ACTN3	1.66e-04	12	56	2	8618961
Pubmed	Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis.	RB1 CUX1	1.66e-04	12	56	2	24056077
Pubmed	Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.	ARSK ARRDC1 PREP KIF1B	1.70e-04	171	56	4	28700664
Pubmed	Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.	STARD13 KIF1B	1.96e-04	13	56	2	14697242
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	TTLL12 AHCYL1 XPO5 RNF213 PFKM	1.97e-04	332	56	5	32786267
Pubmed	Filamin C is Essential for mammalian myocardial integrity.	ACTN4 ACTN2	2.29e-04	14	56	2	36706168
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	CEBPZ ZC3H13 RNF213 CUX1	2.39e-04	187	56	4	26460568
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	AHCYL1 XPO5 RNF213 C5 POMT1 CUX1 LCLAT1 ELOVL7	2.83e-04	1061	56	8	33845483
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	STARD13 AHCYL1 RB1 CEBPZ ACTN4 PFKM DUS3L DHX34 ARMCX1	2.89e-04	1353	56	9	29467282
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	IGBP1 IPO8 KIF1B ACTN4 PPEF1 CUX1	3.15e-04	573	56	6	28330616
Pubmed	The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses.	CUX1 SMAD5	3.41e-04	17	56	2	34184027
Pubmed	Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.	CUX1 CRK	3.41e-04	17	56	2	20620871
Pubmed	ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.	RB1 CUX1	3.41e-04	17	56	2	26581405
Pubmed	HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts.	ACTN2 SMAD5	4.28e-04	19	56	2	26113728
Pubmed	The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.	ADAMTS12 SMAD5	4.28e-04	19	56	2	29618652
Pubmed	Transcriptional fates of human-specific segmental duplications in brain.	NOTCH2NLA NOTCH2NLC	4.28e-04	19	56	2	30228200
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	IPO8 SACS NOTCH2NLA ACTN4 ACTN2 CRK	4.31e-04	608	56	6	16713569
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	AHCYL1 NWD2 SACS KIF1B ACTN4 LIMCH1 ACTN2 ACTN3 PFKM	4.36e-04	1431	56	9	37142655
Pubmed	Early dorsomedial tissue interactions regulate gyrification of distal neocortex.	CUX1 SMAD5	5.24e-04	21	56	2	31729356
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	XPO5 CEBPZ RNF213 DHX34	7.14e-04	250	56	4	33536335
Pubmed	SOCS2 Binds to and Regulates EphA2 through Multiple Mechanisms.	TTLL12 NWD2 CRK	7.55e-04	110	56	3	28883622
Pubmed	Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells.	RB1 CUX1	8.07e-04	26	56	2	34469723
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	AHCYL1 IGBP1 CEBPZ KIF1B ACTN4 LIMCH1 PFKM CUX1	8.23e-04	1247	56	8	27684187
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	AHCYL1 RNF213 ACTN4 LIMCH1	8.74e-04	264	56	4	32814769
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	AHCYL1 IPO8 XPO5 PREP ACTN4 PFKM PPEF1	9.28e-04	974	56	7	28675297
Pubmed	Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice.	ACTN4 ACTN2	9.37e-04	28	56	2	30947518
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	NUAK1 ARMCX1 NPNT	9.49e-04	119	56	3	28625976
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	CEBPZ ZC3H13 ACTN4 LIMCH1 CUX1	1.02e-03	477	56	5	31300519
Pubmed	Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.	ACTN2 CRK	1.08e-03	30	56	2	24472646
Pubmed	A genome-wide association study of behavioral disinhibition.	STARD13 FAXC	1.08e-03	30	56	2	23942779
Pubmed	A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.	RB1 XPO5 LIMCH1	1.09e-03	125	56	3	21654808
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	NTHL1 CABIN1 DUS3L SMAD5	1.10e-03	281	56	4	24163370
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	LIMCH1 ACTN2 PFKM	1.14e-03	127	56	3	30335684
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	NUAK1 RB1	1.15e-03	31	56	2	31636950
Pubmed	Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.	ACTN4 ACTN2	1.15e-03	31	56	2	14630798
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TTLL12 NOXO1 RB1 ZC3H13 EXOC3L4 RNF213	1.16e-03	736	56	6	29676528
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	AHCYL1 NOTCH2NLA ACTN4 ACTN2 PFKM CRK	1.21e-03	742	56	6	26871637
Pubmed	HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.	RB1 CUX1	1.22e-03	32	56	2	11748221
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	IGBP1 KIF1B ACTN4 ACTN2 ACTN3	1.22e-03	497	56	5	23414517
Pubmed	Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.	RB1 CABIN1	1.30e-03	33	56	2	19817957
Pubmed	Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling.	RB1 SMAD5	1.30e-03	33	56	2	29950483
Interaction	MYOZ2 interactions	ACTN4 ACTN2 ACTN3 CRK	3.50e-07	22	55	4	int:MYOZ2
GeneFamily	Actinins	ACTN4 ACTN2 ACTN3	2.21e-08	4	33	3	1112
ToppCell	facs-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 NUAK1 LIMCH1 LCLAT1 NPNT	3.31e-06	182	56	5	dbe4b2557cf19e0682ed446f8397d3a1153642f0
ToppCell	facs-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 NUAK1 LIMCH1 LCLAT1 NPNT	3.31e-06	182	56	5	c557de6ccd327c46e0a5423cd9936d78e0abae5f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS12 NUAK1 LIMCH1 LCLAT1 NPNT	4.52e-06	194	56	5	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	severe_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	STARD13 EPS8L1 SLC4A3 ARMCX1	4.78e-05	159	56	4	e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCell	severe_COVID-19-pDC\|severe_COVID-19 / disease group, cell group and cell class (v2)	STARD13 EPS8L1 SLC4A3 ARMCX1	4.78e-05	159	56	4	ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCell	facs-Lung-nan-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST1 TUBGCP5 CUX1 ELOVL7	6.20e-05	170	56	4	67d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell	facs-Lung-nan-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST1 TUBGCP5 CUX1 ELOVL7	6.20e-05	170	56	4	8e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NWD2 NUAK1 LIMCH1 ACTN2	7.74e-05	180	56	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NWD2 NUAK1 LIMCH1 ACTN2	7.74e-05	180	56	4	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	10x5'-lymph-node_spleen-Myeloid_Dendritic-migDC\|lymph-node_spleen / Manually curated celltypes from each tissue	NOXO1 EXOC3L4 LIMCH1 ELOVL7	7.90e-05	181	56	4	94680f8dbdf22d83801abc0819417751d363fb12
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	NUAK1 LIMCH1 LCLAT1 NPNT	8.07e-05	182	56	4	ceb37c214662a48efb56ab0d015977c6fab478b0
ToppCell	droplet-Lung-nan-3m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 NUAK1 LIMCH1 NPNT	8.42e-05	184	56	4	89ac32e374a4379e4a6c6ea7603b1378b77c147f
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD13 NUAK1 LIMCH1 NPNT	8.42e-05	184	56	4	4df6027fa635996c1eddb920f88a5265772df1cd
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	ADAMTS12 NUAK1 LIMCH1 ACTN2	8.96e-05	187	56	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	STARD13 NUAK1 LIMCH1 NPNT	9.53e-05	190	56	4	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ADAMTS12 LIMCH1 LCLAT1 NPNT	9.73e-05	191	56	4	3379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ADAMTS12 LIMCH1 LCLAT1 NPNT	9.73e-05	191	56	4	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADAMTS12 NUAK1 LIMCH1 NPNT	9.73e-05	191	56	4	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 NUAK1 LIMCH1 ACTN2	1.01e-04	193	56	4	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	ADAMTS12 NUAK1 LIMCH1 NPNT	1.01e-04	193	56	4	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 NUAK1 LIMCH1 ACTN2	1.01e-04	193	56	4	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 NUAK1 LIMCH1 ACTN2	1.01e-04	193	56	4	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDST1 LIMCH1 CUX1 NPNT	1.03e-04	194	56	4	ad3eb98f94a007c5988ede06238255f5b03bee6e
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS12 NUAK1 LIMCH1 ACTN2	1.03e-04	194	56	4	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	E18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDST1 LIMCH1 CUX1 NPNT	1.03e-04	194	56	4	a281ebab117589fc922ead0a712cfe0a844c94ac
ToppCell	Control-Stromal-Myofibroblast\|Control / Disease state, Lineage and Cell class	ADAMTS12 NUAK1 LIMCH1 NPNT	1.05e-04	195	56	4	ffcf76cd72e43d8cf1058a49c76e0956065038bc
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS12 LIMCH1 ACTN2 NPNT	1.05e-04	195	56	4	df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDST1 LIMCH1 CUX1 NPNT	1.07e-04	196	56	4	9790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NDST1 LIMCH1 CUX1 NPNT	1.07e-04	196	56	4	b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS12 LIMCH1 ACTN2 NPNT	1.07e-04	196	56	4	cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS12 LIMCH1 ACTN2 NPNT	1.10e-04	197	56	4	94a9603cbd3516fbcce871909693b88f20d41713
ToppCell	(5)_Dendritic_cell-(53)_Lymphoid_DC\|(5)_Dendritic_cell / shred on Cell_type and subtype	EDARADD LIMCH1 DHX34 ELOVL7	1.12e-04	198	56	4	548da5fa86f9756c503ed77bcdde55bc4d1a2726
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	STARD13 LIMCH1 CUX1 NPNT	1.12e-04	198	56	4	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ADAMTS12 NUAK1 LIMCH1 ACTN2	1.14e-04	199	56	4	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ADAMTS12 NUAK1 LIMCH1 ACTN2	1.14e-04	199	56	4	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	EPS8L1 LIMCH1 C5 NPNT	1.16e-04	200	56	4	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	ADAMTS12 LIMCH1 ACTN2 NPNT	1.16e-04	200	56	4	aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ADAMTS12 LIMCH1 ACTN2 NPNT	1.16e-04	200	56	4	a510deaada669e690329183e18df02870bd204b3
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADAMTS12 LIMCH1 ACTN2 NPNT	1.16e-04	200	56	4	dd4228cbed8a4395166a6332e08d44d88bebe3b9
Drug	Acetohexamide [968-81-0]; Up 200; 12.4uM; HL60; HT_HG-U133A	IGBP1 IPO8 ACTN2 CABIN1 DHX34 CRK SMAD5	3.82e-07	195	54	7	1870_UP
Drug	Adrenosterone [382-45-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A	STARD13 NDST1 LIMCH1 ACTN2 CABIN1 DHX34	7.53e-06	199	54	6	5464_DN
Disease	focal segmental glomerulosclerosis 1 (implicated_via_orthology)	ACTN4 ACTN2 ACTN3	5.78e-08	5	54	3	DOID:0111128 (implicated_via_orthology)
Disease	platelet measurement	EXOC3L4 KIF1B ACTN4 CUX1 ELOVL7	2.77e-04	315	54	5	EFO_0005036
Disease	immature platelet fraction	EXOC3L4 KIF1B CUX1	1.21e-03	114	54	3	EFO_0009187
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	XPO5 ACTN4	1.38e-03	30	54	2	C1868672

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRWHQDWQKEPRKYE	ARSK	506	Q6UWY0
RDWLTQDWLHPLMDK	EXOC3L4	536	Q17RC7
DRSQEPHWRETARWI	SLC4A3	331	P48751
PHWRETARWIKFEED	SLC4A3	336	P48751
WDRDLLLDPAWEKQQ	ACTN2	26	P35609
KDHWWSAVQPERRNA	CUX1	821	P39880
DDWDRDLLLDPAWEK	ACTN4	36	O43707
KPWLFTEIKEQRHWD	DUS3L	526	Q96G46
KAWRRAQWHEQILVP	ARRDC1	231	Q8N5I2
ELWREKWERHNLPSR	ADAMTS12	221	P58397
GDILRIRDKPEEQWW	CRK	156	P46108
ENDDARKLWWLPAHL	NWD2	521	Q9ULI1
IPDHVRERAWLTWEK	RB1	66	P06400
WERDREVWNGKEHDE	NOTCH2NLA	221	Q7Z3S9
IRRKFWPEWHHDDDN	FAXC	326	Q5TGI0
WIREKDNDLHWEPIR	NPNT	431	Q6UXI9
WRPRGDSLILEHQWE	KIF1B	1481	O60333
QLWCHKRWEEKEERL	LCLAT1	301	Q6UWP7
DEQTLHRAREWDDWK	IGBP1	311	P78318
HRAREWDDWKDTHPR	IGBP1	316	P78318
DFEHRIPKEQWWLKL	PFKM	731	P08237
LWQDPCEDKRHKDIW	NDST1	581	P52848
WKDEPDDRSWLEHHV	TUBGCP5	206	Q96RT8
WERDREVWNGKEHDE	NOTCH2NLC	221	P0DPK4
QWLQPHREWKEEVLD	OASL	21	Q15646
DVNNWWIVKDPRRHQ	POMT1	371	Q9Y6A1
WKVLVPEHEKDVLEW	PREP	326	P48147
EAEAQLWWAAKELRR	CFAP298	186	P57076
LPWIILHRIIWQEED	CABIN1	846	Q9Y6J0
NWIKDADPRVEDWLL	ELOVL7	16	A1L3X0
ESWLWEVHLVPRRKQ	C5	771	P01031
VEKVLRRWVDEEWPK	EDARADD	191	Q8WWZ3
DDLRVIVWDWVRQKP	DCAF8L1	216	A6NGE4
EVLDDSRKWWKVRDP	EPS8L1	506	Q8TE68
WDPVKVHDIRWNFEK	GPX5	171	O75715
HRAPSEEEALEKWDW	DHX34	16	Q14147
SIKWRELDQWRDPAA	SACS	476	Q9NZJ4
KQLRWEAERDDWLHN	CEBPZ	1011	Q03701
WAWDPEEERRRQEKW	LIMCH1	766	Q9UPQ0
HEWEQIIDILWSDPR	PPEF1	351	O14829
LHIDEDDRPELVWWK	IPO8	246	O15397
IRWLRVHAPEVDWIK	RTL1	506	A6NKG5
LRERHLWDEDFVQWK	STARD13	971	Q9Y3M8
ENWPSEEEIRRFWKL	LRRC27	251	Q9C0I9
WERVRSQVDHVIWPD	AHCYL1	416	O43865
EQWHPLREWLGRLEA	KCP	51	Q6ZWJ8
LEEWLPRELWHEING	NTHL1	266	P78549
PDRRATIEDIANHWW	NUAK1	291	O60285
LRHPSGWWLVENEDR	NOXO1	196	Q8NFA2
RVWRWPDLQSHHELK	SMAD5	91	Q99717
EDWDRDLLLDPAWEK	ACTN3	31	Q08043
RLAWGRDENEKIWDE	ARMCX1	26	Q9P291
PRHKDAWRQPEDTWA	RNF213	706	Q63HN8
WKPHKWVDVRLALEQ	TECPR1	621	Q7Z6L1
REWPQHWPDMLIELD	XPO5	126	Q9HAV4
LEPVLDRDRWSWDRH	nan	521	Q6ZUG5
QRERWGEDNHWICKP	TTLL12	406	Q14166
DGEEQRPRKAWAWRL	SUOX	476	P51687
REWDRDADKDWPRNR	ZC3H13	1321	Q5T200