Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninsulin receptor activity

IGF1R INSRR

1.37e-063142GO:0005009
GeneOntologyMolecularFunctioninsulin receptor substrate binding

IGF1R INSRR

4.77e-0515142GO:0043560
GeneOntologyMolecularFunctionprotein-hormone receptor activity

IGF1R INSRR

1.05e-0422142GO:0016500
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

IGF1R INSRR

4.05e-0443142GO:0043548
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

IGF1R INSRR

9.26e-0465142GO:0004714
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

IGF1R INSRR

1.58e-0385142GO:0019199
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

IGF1R INSRR

4.50e-03145142GO:0004713
GeneOntologyBiologicalProcessmale sex determination

IGF1R INSRR

5.11e-0516142GO:0030238
GeneOntologyBiologicalProcessdevelopmental process involved in reproduction

TCF23 FGF8 INPP5B SEPTIN14 IGF1R INSRR

9.01e-051235146GO:0003006
GeneOntologyBiologicalProcesssex determination

IGF1R INSRR

1.97e-0431142GO:0007530
GeneOntologyCellularComponentinsulin receptor complex

IGF1R INSRR

3.29e-064162GO:0005899
DomainTyr_kinase_insulin-like_rcpt

IGF1R INSRR

1.81e-063152IPR016246
DomainFurin-like

IGF1R INSRR

1.26e-057152PF00757
DomainRcpt_L-dom

IGF1R INSRR

1.26e-057152IPR000494
DomainFurin-like_Cys-rich_dom

IGF1R INSRR

1.26e-057152IPR006211
DomainRecep_L_domain

IGF1R INSRR

1.26e-057152PF01030
Domain-

IGF1R INSRR

1.26e-0571523.80.20.20
DomainTyr_kinase_rcpt_2_CS

IGF1R INSRR

3.30e-0511152IPR002011
DomainRECEPTOR_TYR_KIN_II

IGF1R INSRR

3.96e-0512152PS00239
DomainFurin_repeat

IGF1R INSRR

9.14e-0518152IPR006212
DomainFU

IGF1R INSRR

9.14e-0518152SM00261
DomainTyrKc

IGF1R INSRR

2.21e-0388152SM00219
DomainTyr_kinase_cat_dom

IGF1R INSRR

2.21e-0388152IPR020635
DomainPROTEIN_KINASE_TYR

IGF1R INSRR

2.68e-0397152PS00109
DomainTyr_kinase_AS

IGF1R INSRR

2.68e-0397152IPR008266
DomainPkinase_Tyr

IGF1R INSRR

4.69e-03129152PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

IGF1R INSRR

5.34e-03138152IPR001245
DomainGrowth_fac_rcpt_

IGF1R INSRR

6.78e-03156152IPR009030
Domainfn3

IGF1R INSRR

7.29e-03162152PF00041
DomainFN3

IGF1R INSRR

9.41e-03185152SM00060
DomainFN3

IGF1R INSRR

1.08e-02199152PS50853
DomainFN3_dom

IGF1R INSRR

1.19e-02209152IPR003961
DomainL_dom-like

IGF1R INSRR

2.78e-02328152IPR032675
PathwayREACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R

FGF8 IGF1R

3.86e-044792MM14885
PathwayREACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R

FGF8 IGF1R

5.10e-045492M27168
PathwayKEGG_MELANOMA

FGF8 IGF1R

8.80e-047192M15798
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_PI3K_SIGNALING_PATHWAY

FGF8 IGF1R

1.20e-038392M47961
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY

FGF8 IGF1R

1.38e-038992M47963
PathwayKEGG_PROSTATE_CANCER

IGF1R INSRR

1.38e-038992M13191
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY

FGF8 IGF1R

1.47e-039292M47927
PathwayWP_BREAST_CANCER_PATHWAY

FGF8 IGF1R

4.06e-0315492M39739
PathwayKEGG_REGULATION_OF_ACTIN_CYTOSKELETON

FGF8 INSRR

7.63e-0321392M18306
PathwayWP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING

FGF8 IGF1R

1.49e-0230292M39719
Pubmed

Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas.

IGF1R INSRR

1.98e-07216214654552
Pubmed

Insulin receptor-related receptor as an extracellular alkali sensor.

IGF1R INSRR

5.95e-07316221641549
Pubmed

Insulin receptor-related (Irr) is expressed in pre-implantation embryos: a possible relationship to "growth factor Y" and sex determination.

IGF1R INSRR

5.95e-07316221681845
Pubmed

The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.

IGF1R INSRR

1.98e-06516219001411
Pubmed

Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.

IGF1R INSRR

5.55e-06816215629149
Pubmed

Testis determination requires insulin receptor family function in mice.

IGF1R INSRR

1.54e-051316214628051
Pubmed

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.

COIL DKC1

2.08e-051516223685356
Pubmed

Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family.

FGF8 IGF1R

2.37e-051616223584732
Pubmed

Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.

COIL DKC1

2.37e-051616225416818
Pubmed

FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size.

FGF8 ENTPD2

5.44e-052416221655085
Pubmed

RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.

FGF8 IGF1R

9.76e-053216220111592
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

IGF1R INSRR

1.53e-044016230898150
InteractionWDR36 interactions

COIL DKC1 FGF8 UBN1

1.02e-05208144int:WDR36
InteractionDDX56 interactions

COIL DKC1 FGF8 INSRR

4.51e-05304144int:DDX56
InteractionFIGLA interactions

TCF23 SEPTIN14

6.06e-0517142int:FIGLA
GeneFamilyReceptor Tyrosine Kinases|CD molecules

IGF1R INSRR

2.59e-0440112321
GeneFamilyFibronectin type III domain containing

IGF1R INSRR

4.06e-03160112555
ComputationalGenes in the cancer module 284.

DKC1 IGF1R

4.72e-044582MODULE_284
Diseasealcohol dependence (implicated_via_orthology)

IGF1R INSRR

8.67e-069152DOID:0050741 (implicated_via_orthology)
Diseaseprostatic hypertrophy (is_marker_for)

FGF8 IGF1R

1.32e-0511152DOID:11132 (is_marker_for)
Diseasesleep disorder (implicated_via_orthology)

IGF1R INSRR

1.32e-0511152DOID:535 (implicated_via_orthology)
Diseasediabetic neuropathy (implicated_via_orthology)

IGF1R INSRR

2.19e-0514152DOID:9743 (implicated_via_orthology)
Diseasethyroid volume

MICOS10 IGF1R

2.88e-0516152EFO_0004865
Diseasediabetes mellitus (implicated_via_orthology)

IGF1R INSRR

7.78e-0526152DOID:9351 (implicated_via_orthology)
Diseaseglucose metabolism disease (implicated_via_orthology)

IGF1R INSRR

9.05e-0528152DOID:4194 (implicated_via_orthology)
Diseasehigh grade glioma (is_implicated_in)

IGF1R ENTPD2

2.05e-0442152DOID:3070 (is_implicated_in)
Diseasehigh grade glioma (implicated_via_orthology)

IGF1R INSRR

2.25e-0444152DOID:3070 (implicated_via_orthology)
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

IGF1R INSRR

1.28e-03105152DOID:9352 (implicated_via_orthology)
DiseaseGlioblastoma Multiforme

SEPTIN14 INSRR

1.43e-03111152C1621958
DiseaseParkinson's disease (implicated_via_orthology)

IGF1R INSRR

2.82e-03157152DOID:14330 (implicated_via_orthology)
Diseasecardioembolic stroke

GPR150 IGF1R

3.30e-03170152EFO_1001976
Diseasebreast cancer (is_marker_for)

FGF8 IGF1R

3.89e-03185152DOID:1612 (is_marker_for)
Diseasehypertension (biomarker_via_orthology)

IGF1R ENTPD2

5.79e-03227152DOID:10763 (biomarker_via_orthology)
Diseasecomplex trait

TCF23 IGF1R

8.15e-03271152EFO_0010578
Diseasehypothyroidism

INPP5B MICOS10

8.92e-03284152EFO_0004705

Protein segments in the cluster

PeptideGeneStartEntry
IKYGWVGRWFRPRKG

ENTPD2

181

Q9Y5L3
YRKGGKGLLPVRWMS

IGF1R

1166

P08069
LFSWKGAKGRGMRGR

COIL

401

P38432
YQFRLMGPGKWDGAR

FMO6P

476

O60774
GWYMAFTRKGRPRKG

FGF8

166

P55075
KRYRRWMKNEGPGRL

DNAJC25

341

Q9H1X3
YRKGGKGLLPVRWMA

INSRR

1146

P14616
GGGRYPSRKKRWGLE

INPP5B

176

P32019
GYPMSAAYGRRWRRK

KIAA1210

526

Q9ULL0
MERDTYPRKWGLGPK

DKC1

371

O60832
FKRRMWPLAFGSGMG

MICOS10

36

Q5TGZ0
VGKRMVRGRHYPWGV

SEPTIN14

256

Q6ZU15
GGPWAGPKRRKMDFL

GPR150

71

Q8NGU9
GGKPFRWYKDRDALM

ZNF132

166

P52740
KGGRRIMGPRKKFQW

UBN1

501

Q9NPG3
KWPMRSRLYAGGLGY

TCF23

156

Q7RTU1