Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	LRRC8C PKD1L1 SLC22A11 ABCA10 SLC66A1 C2CD2L SLC35D1 SLC22A18 CLCN1 SLCO1C1 KCNF1 GET3 SFXN3 SFXN2 KCNN3 ABCB11 KCNS2 CACNA1G SLC49A3 ATP1A4	4.33e-06	1289	99	20	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	LRRC8C PKD1L1 SLC22A11 ABCA10 SLC66A1 SLC35D1 SLC22A18 CLCN1 SLCO1C1 KCNF1 GET3 SFXN3 SFXN2 KCNN3 ABCB11 KCNS2 CACNA1G SLC49A3 ATP1A4	4.61e-06	1180	99	19	GO:0022857
GeneOntologyMolecularFunction	olfactory receptor activity	OR4C6 OR11H12 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	9.56e-06	431	99	11	GO:0004984
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	7.28e-05	3	99	2	GO:0018858
GeneOntologyMolecularFunction	DNA end binding	XRCC5 NHEJ1	7.28e-05	3	99	2	GO:0045027
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	1.45e-04	4	99	2	GO:0102391
GeneOntologyMolecularFunction	ATP-dependent activity	RAD51B DNAH3 MYO18A XRCC5 ABCA10 GET3 ABCB11 ATP1A4 DDX21 ACSM2A ACSM2B	2.31e-04	614	99	11	GO:0140657
GeneOntologyMolecularFunction	ATP hydrolysis activity	RAD51B DNAH3 MYO18A XRCC5 ABCA10 GET3 ABCB11 ATP1A4 DDX21	3.45e-04	441	99	9	GO:0016887
GeneOntologyMolecularFunction	lipopolysaccharide immune receptor activity	SCARB1 TLR4	3.60e-04	6	99	2	GO:0001875
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR4C6 MC2R OR11H12 BDKRB2 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	4.19e-04	884	99	13	GO:0004930
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC22A11 SLC66A1 SLC35D1 SLC22A18 SLCO1C1 SFXN3 ABCB11	6.42e-04	293	99	7	GO:0008514
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	6.68e-04	8	99	2	GO:0004321
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR4C6 MC2R LMBR1 OR11H12 CLEC12A BDKRB2 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 TLR4 OR2V2 OR4D5 OR11H2	9.73e-04	1353	99	16	GO:0004888
GeneOntologyMolecularFunction	metallodipeptidase activity	DPEP2 DPEP3	1.07e-03	10	99	2	GO:0070573
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	1.30e-03	11	99	2	GO:0031956
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR4C6 OR11H12 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 SCARB1 TLR4 OR2V2 OR4D5 OR11H2	9.33e-07	524	96	13	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR4C6 OR11H12 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	5.34e-06	432	96	11	GO:0050911
GeneOntologyBiologicalProcess	detection of stimulus	OR4C6 PKD1L1 OR11H12 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 SCARB1 TLR4 OR2V2 OR4D5 OR11H2	6.15e-06	722	96	14	GO:0051606
GeneOntologyBiologicalProcess	sensory perception of smell	OR4C6 OR11H12 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	1.07e-05	465	96	11	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR4C6 OR11H12 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	1.58e-05	485	96	11	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR4C6 OR11H12 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 TLR4 OR2V2 OR4D5 OR11H2	1.64e-05	582	96	12	GO:0050906
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR4C6 OR11H12 OR1N1 OR13D1 OR12D2 OR12D1 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	4.75e-05	547	96	11	GO:0007606
GeneOntologyBiologicalProcess	serine import into mitochondrion	SFXN3 SFXN2	6.41e-05	3	96	2	GO:0140300
GeneOntologyBiologicalProcess	carboxylic acid transport	LRRC8C SLC22A11 SLC66A1 BDKRB2 SLC35D1 SLCO1C1 SFXN3 SFXN2 ABCB11	1.25e-04	410	96	9	GO:0046942
GeneOntologyBiologicalProcess	organic acid transport	LRRC8C SLC22A11 SLC66A1 BDKRB2 SLC35D1 SLCO1C1 SFXN3 SFXN2 ABCB11	1.30e-04	412	96	9	GO:0015849
Domain	Olfact_rcpt	OR4C6 OR11H12 OR1N1 OR13D1 OR12D2 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	4.10e-05	393	98	10	IPR000725
Domain	Renal_dipep_fam	DPEP2 DPEP3	8.15e-05	3	98	2	IPR008257
Domain	RENAL_DIPEPTIDASE_1	DPEP2 DPEP3	8.15e-05	3	98	2	PS00869
Domain	RENAL_DIPEPTIDASE_2	DPEP2 DPEP3	8.15e-05	3	98	2	PS51365
Domain	Peptidase_M19	DPEP2 DPEP3	8.15e-05	3	98	2	PF01244
Domain	Dipep_AS	DPEP2 DPEP3	8.15e-05	3	98	2	IPR000180
Domain	GPCR_Rhodpsn_7TM	OR4C6 MC2R OR11H12 BDKRB2 OR1N1 OR13D1 OR12D2 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	1.99e-04	670	98	12	IPR017452
Domain	G_PROTEIN_RECEP_F1_2	OR4C6 MC2R OR11H12 BDKRB2 OR1N1 OR13D1 OR12D2 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	2.64e-04	691	98	12	PS50262
Domain	GPCR_Rhodpsn	OR4C6 MC2R OR11H12 BDKRB2 OR1N1 OR13D1 OR12D2 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	2.68e-04	692	98	12	IPR000276
Domain	Mtc	SFXN3 SFXN2	2.70e-04	5	98	2	PF03820
Domain	Mtc	SFXN3 SFXN2	2.70e-04	5	98	2	IPR004686
Domain	ARM-type_fold	MON2 USP24 HSPBP1 HUWE1 PSME4 ARID2 ANKAR TTC12	4.13e-04	339	98	8	IPR016024
Domain	ARM-like	MON2 HSPBP1 HUWE1 PSME4 ARID2 ANKAR TTC12	5.51e-04	270	98	7	IPR011989
Domain	K_chnl_volt-dep_Kv9	KCNF1 KCNS2	5.63e-04	7	98	2	IPR003971
Domain	7tm_1	OR4C6 MC2R OR11H12 BDKRB2 OR1N1 OR13D1 OR12D2 OR11H1 OR2AT4 OR2V2 OR4D5	8.38e-04	677	98	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR4C6 MC2R OR11H12 BDKRB2 OR1N1 OR13D1 OR12D2 OR11H1 OR2AT4 OR2V2 OR4D5	9.22e-04	685	98	11	PS00237
Domain	RFX_DNA_binding	RFX8 ARID2	9.58e-04	9	98	2	PF02257
Domain	DNA-bd_RFX	RFX8 ARID2	9.58e-04	9	98	2	IPR003150
Domain	RFX_DBD	RFX8 ARID2	9.58e-04	9	98	2	PS51526
Domain	MFS	SLC22A11 SLC22A18 SLCO1C1 SLC49A3	2.52e-03	108	98	4	PS50850
Domain	Acyltransferase	GPAT3 LPCAT2	3.12e-03	16	98	2	PF01553
Domain	Channel_four-helix_dom	KCNF1 KCNS2 CACNA1G	3.34e-03	57	98	3	IPR027359
Domain	-	KCNF1 KCNS2 CACNA1G	3.34e-03	57	98	3	1.20.120.350
Domain	PlsC	GPAT3 LPCAT2	3.52e-03	17	98	2	SM00563
Domain	Plipid/glycerol_acylTrfase	GPAT3 LPCAT2	3.52e-03	17	98	2	IPR002123
Domain	AMP-bd_C	ACSM2A ACSM2B	3.52e-03	17	98	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	3.52e-03	17	98	2	PF13193
Pubmed	Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.	MC2R SFXN3 ACSM2A ACSM2B	7.77e-07	25	100	4	19372376
Pubmed	A protein interaction landscape of breast cancer.	RAD51B MYO18A GPAT3 RO60 XPC HSPBP1 XRCC5 UBR5 ARID2 LOXL4 DDX21	2.21e-06	634	100	11	34591612
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4C6 OR1N1 OR13D1 OR12D2 OR12D1 OR2AT4 OR2V2 OR4D5	6.55e-06	340	100	8	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4C6 OR1N1 OR13D1 OR12D2 OR12D1 OR2AT4 OR2V2 OR4D5	6.55e-06	340	100	8	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4C6 OR1N1 OR13D1 OR12D2 OR12D1 OR2AT4 OR2V2 OR4D5	6.98e-06	343	100	8	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4C6 OR1N1 OR13D1 OR12D2 OR12D1 OR2AT4 OR2V2 OR4D5	7.44e-06	346	100	8	14611657
Pubmed	Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene.	BDKRB2 KNG1	8.18e-06	2	100	2	1329734
Pubmed	Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator.	BDKRB2 KNG1	8.18e-06	2	100	2	30478260
Pubmed	Bradykinin promotes the chemotactic invasion of primary brain tumors.	BDKRB2 KNG1	8.18e-06	2	100	2	21451024
Pubmed	High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells.	BDKRB2 KNG1	8.18e-06	2	100	2	21586566
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	8.18e-06	2	100	2	19634011
Pubmed	Bradykinin stimulates prostaglandin E2 release in human skeletal muscular fibroblasts.	BDKRB2 KNG1	8.18e-06	2	100	2	32114020
Pubmed	Bradykinin B2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro.	BDKRB2 KNG1	8.18e-06	2	100	2	12851878
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	8.18e-06	2	100	2	16521160
Pubmed	Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts.	BDKRB2 KNG1	8.18e-06	2	100	2	20050188
Pubmed	Regulation of kinin B(2) receptors by bradykinin in human lung cells.	BDKRB2 KNG1	8.18e-06	2	100	2	18783336
Pubmed	Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4.	TLR4 SERPINE1	8.18e-06	2	100	2	27317488
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	8.18e-06	2	100	2	29948332
Pubmed	Possible regulation of Toll-like receptor 4 by lysine acetylation through LPCAT2 activity in RAW264.7 cells.	LPCAT2 TLR4	8.18e-06	2	100	2	35735109
Pubmed	Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis.	BDKRB2 SERPINE1	8.18e-06	2	100	2	19628666
Pubmed	The bradykinin B2 receptor in the early immune response against Listeria infection.	BDKRB2 KNG1	8.18e-06	2	100	2	18810490
Pubmed	Second kininase in human blood plasma.	BDKRB2 KNG1	2.45e-05	3	100	2	6055465
Pubmed	TLR2, TLR4 and CD86 gene polymorphisms in recurrent aphthous stomatitis.	CD86 TLR4	2.45e-05	3	100	2	25482673
Pubmed	CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways.	CD86 TLR4	2.45e-05	3	100	2	16709832
Pubmed	Identification of two additional members of the membrane-bound dipeptidase family.	DPEP2 DPEP3	2.45e-05	3	100	2	12738806
Pubmed	Variants in XPC, Noxa and TLR4 genes are not associated with bleomycin-induced lung injury in Hodgkin lymphoma patients.	XPC TLR4	2.45e-05	3	100	2	32320335
Pubmed	Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.	BDKRB2 TLR4	2.45e-05	3	100	2	17056563
Pubmed	Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor.	BDKRB2 KNG1	2.45e-05	3	100	2	1314587
Pubmed	Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.	DPEP2 DPEP3	2.45e-05	3	100	2	32325220
Pubmed	Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.	BDKRB2 KNG1	2.45e-05	3	100	2	37703419
Pubmed	A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.	BDKRB2 KNG1	2.45e-05	3	100	2	4322742
Pubmed	Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2.	BDKRB2 KNG1	2.45e-05	3	100	2	31059006
Pubmed	XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.	XRCC5 NHEJ1	2.45e-05	3	100	2	30291363
Pubmed	Bradykinin system is involved in endometriosis-related pain through endothelin-1 production.	BDKRB2 KNG1	2.45e-05	3	100	2	29034546
Pubmed	The Role of TLR4 and Fyn Interaction on Lipopolysaccharide-Stimulated PAI-1 Expression in Astrocytes.	TLR4 SERPINE1	2.45e-05	3	100	2	25106729
Pubmed	The human olfactory receptor gene family.	OR4C6 OR1N1 OR13D1 OR12D2 OR11H1 OR2AT4 OR2V2 OR4D5 OR11H2	2.71e-05	541	100	9	14983052
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	HUWE1 UBR5 GET3	3.41e-05	22	100	3	24981174
Pubmed	Tumor-Secreted Extracellular Vesicles Regulate T-Cell Costimulation and Can Be Manipulated To Induce Tumor-Specific T-Cell Responses.	CD86 TLR4	4.89e-05	4	100	2	33895168
Pubmed	DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.	MYO18A XRCC5	4.89e-05	4	100	2	24485452
Pubmed	Activation of macrophages by P2X7-induced microvesicles from myeloid cells is mediated by phospholipids and is partially dependent on TLR4.	CD86 TLR4	4.89e-05	4	100	2	20709956
Pubmed	X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology.	XRCC5 NHEJ1	4.89e-05	4	100	2	34056803
Pubmed	Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems.	BDKRB2 SERPINE1	4.89e-05	4	100	2	20856803
Pubmed	Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells.	CD86 TLR4	4.89e-05	4	100	2	27569212
Pubmed	Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF.	XRCC5 NHEJ1	4.89e-05	4	100	2	21349273
Pubmed	Online nanoflow RP-RP-MS reveals dynamics of multicomponent Ku complex in response to DNA damage.	XRCC5 DDX21	4.89e-05	4	100	2	20873769
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	4.89e-05	4	100	2	32830538
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CLCN1 KCNF1 KCNN3 KCNS2 CACNA1G	5.27e-05	139	100	5	16985003
Pubmed	Variation within DNA repair pathway genes and risk of multiple sclerosis.	RAD51B XPC XRCC5 NHEJ1	5.70e-05	72	100	4	20522537
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	USP24 RO60 HSPBP1 HUWE1 PFKL XRCC5 DDX21	6.35e-05	344	100	7	36282215
Pubmed	Astrocyte galectin-9 potentiates microglial TNF secretion.	CD86 TLR4	8.14e-05	5	100	2	25158758
Pubmed	Bradykinin enhances cell migration in human chondrosarcoma cells through BK receptor signaling pathways.	BDKRB2 KNG1	8.14e-05	5	100	2	19885862
Pubmed	Activity-Based Probes for HECT E3 Ubiquitin Ligases.	HUWE1 UBR5	8.14e-05	5	100	2	28425671
Pubmed	SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.	SFXN3 SFXN2	8.14e-05	5	100	2	30442778
Pubmed	RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.	XRCC5 NHEJ1	8.14e-05	5	100	2	26833222
Pubmed	Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury.	TLR4 SERPINE1	8.14e-05	5	100	2	18182917
Pubmed	Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels.	BDKRB2 SERPINE1	8.14e-05	5	100	2	17207964
Pubmed	Cooperative assembly of a protein-DNA filament for nonhomologous end joining.	XRCC5 NHEJ1	8.14e-05	5	100	2	23620595
Pubmed	Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.	XRCC5 ABCB11	8.14e-05	5	100	2	19833092
Pubmed	The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis.	BDKRB2 KNG1	8.14e-05	5	100	2	26153520
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	HUWE1 XRCC5 UBR5 DDX21	8.19e-05	79	100	4	26446488
Pubmed	Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.	PKD1L1 HUWE1 PFKL XRCC5 DPEP3 GET3	8.62e-05	249	100	6	30097533
Pubmed	Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis.	TLR4 SERPINE1	1.22e-04	6	100	2	17877801
Pubmed	Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.	XRCC5 NHEJ1	1.22e-04	6	100	2	34352203
Pubmed	HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms.	CD86 TLR4	1.22e-04	6	100	2	24696476
Pubmed	TLR4/NF-κB-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.	TLR4 DDX21	1.22e-04	6	100	2	25692136
Pubmed	Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53.	XRCC5 NHEJ1	1.22e-04	6	100	2	30579708
Pubmed	The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis.	XRCC5 NHEJ1	1.70e-04	7	100	2	31548606
Pubmed	Synthetic lethality between PAXX and XLF in mammalian development.	XRCC5 NHEJ1	1.70e-04	7	100	2	27798842
Pubmed	Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.	XRCC5 NHEJ1	1.70e-04	7	100	2	20383123
Pubmed	γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.	GGT2P TLR4	1.70e-04	7	100	2	27775020
Pubmed	TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres.	XRCC5 NHEJ1	1.70e-04	7	100	2	24095731
Pubmed	XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.	XRCC5 NHEJ1	2.27e-04	8	100	2	25941166
Pubmed	Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk.	BDKRB2 KNG1	2.27e-04	8	100	2	19716087
Pubmed	A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice.	SFXN3 SFXN2	2.27e-04	8	100	2	11274051
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MON2 USP24 MED13L PLCL2	2.37e-04	104	100	4	10470851
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	POLR2F MYO18A NOL11 XPC PFKL FAM120A LPCAT2 SFXN3 DDX21	2.46e-04	724	100	9	36232890
Pubmed	Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy.	MON2 CAV2 HUWE1 SFXN3	2.55e-04	106	100	4	33087821
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	MON2 NOL11 HUWE1 PFKL IDH3G XRCC5 YIPF5 PSME4 UBR5 SFXN2 DDX21 SEC23A	2.65e-04	1257	100	12	37317656
Pubmed	Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.	CAV2 SCARB1 ABCB11	3.41e-04	47	100	3	11208732
Pubmed	Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction.	MED13L CACNA1G	3.63e-04	10	100	2	32672536
Pubmed	DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway.	TLR4 DDX21	4.43e-04	11	100	2	24391503
Pubmed	FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.	XRCC5 NHEJ1	4.43e-04	11	100	2	26774286
Pubmed	The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease.	BDKRB2 KNG1	4.43e-04	11	100	2	19082699
Pubmed	DNA cloning using in vitro site-specific recombination.	MON2 GPR155 CCDC184 NELFB LMBR1 CAV2 IDH3G CLCN1 YY1AP1	4.82e-04	794	100	9	11076863
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	NOL11 XPC HUWE1 PFKL XRCC5 FAM120A PSME4 UBR5 RTCA SFXN3 DDX21 SEC23A	5.12e-04	1353	100	12	29467282
Pubmed	Genetic risk factors in typical haemolytic uraemic syndrome.	BDKRB2 SERPINE1	5.30e-04	12	100	2	19110485
Pubmed	Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production.	CD86 TLR4	5.30e-04	12	100	2	19734906
Pubmed	MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.	XRCC5 NHEJ1	5.30e-04	12	100	2	30017584
Pubmed	Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.	RO60 POF1B FAM120A RTCA	5.38e-04	129	100	4	28973437
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	NOL11 HUWE1 LARS2 FAM120A UBR5	5.69e-04	232	100	5	25515538
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	MYO18A HUWE1 PFKL XRCC5 POF1B UBR5 SFXN3 SEC23A	5.70e-04	647	100	8	26618866
Pubmed	Comprehensive analysis of DNA repair gene variants and risk of meningioma.	RAD51B XPC NHEJ1	6.03e-04	57	100	3	18270339
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP24 NOL11 HUWE1 XRCC5 FAM120A UBR5 DDX21 SEC23A	6.05e-04	653	100	8	22586326
Pubmed	Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.	OR12D2 OR12D1	6.25e-04	13	100	2	14506126
Pubmed	Isolation of human proteasomes and putative proteasome-interacting proteins using a novel affinity chromatography method.	HUWE1 XRCC5 PSME4	6.34e-04	58	100	3	19013454
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	USP24 PFKL UBR5	6.34e-04	58	100	3	31067491
Pubmed	Regulation of error-prone translesion synthesis by Spartan/C1orf124.	HUWE1 FAM120A UBR5	6.67e-04	59	100	3	23254330
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	HUWE1 UBR5	7.28e-04	14	100	2	27626314
Pubmed	Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit.	TLR4 SERPINE1	7.28e-04	14	100	2	19050632
Pubmed	An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.	XRCC5 DDX21	8.39e-04	15	100	2	25735744
Cytoband	6p22.2-p21.31	OR12D2 OR12D1	4.68e-05	5	100	2	6p22.2-p21.31
Cytoband	16p12.3	DNAH3 ACSM2A ACSM2B	5.71e-05	34	100	3	16p12.3
Cytoband	8q22	UBR5 KCNS2	4.84e-04	15	100	2	8q22
Cytoband	2p25	KLF11 KCNF1	7.03e-04	18	100	2	2p25
GeneFamily	Olfactory receptors, family 12	OR12D2 OR12D1	3.58e-05	3	63	2	160
GeneFamily	Olfactory receptors, family 11	OR11H12 OR11H1 OR11H2	6.79e-05	23	63	3	159
GeneFamily	Sideroflexins	SFXN3 SFXN2	1.19e-04	5	63	2	746
GeneFamily	1-acylglycerol-3-phosphate O-acyltransferases	GPAT3 LPCAT2	6.44e-04	11	63	2	46
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	3.68e-03	26	63	2	40
Disease	level of dipeptidase 2 in blood serum	DPEP2 DPEP3	9.83e-06	2	93	2	OBA_2041349
Disease	X-21319 measurement	ACSM2A ACSM2B	9.83e-06	2	93	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	2.94e-05	3	93	2	EFO_0021242
Disease	chronic obstructive pulmonary disease (is_implicated_in)	XRCC5 BDKRB2 CD86 TLR4	4.78e-05	63	93	4	DOID:3083 (is_implicated_in)
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	9.77e-05	5	93	2	EFO_0800378
Disease	Extravasation of Contrast Media	BDKRB2 KNG1	1.46e-04	6	93	2	C0015378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	1.46e-04	6	93	2	EFO_0800106
Disease	low tension glaucoma (is_implicated_in)	CAV2 TLR4	2.72e-04	8	93	2	DOID:13544 (is_implicated_in)
Disease	Industrial Dermatosis	BDKRB2 KNG1	2.72e-04	8	93	2	C0086457
Disease	Dermatitis, Occupational	BDKRB2 KNG1	2.72e-04	8	93	2	C0028796
Disease	X-17676 measurement	DNAH3 ACSM2B	2.72e-04	8	93	2	EFO_0800785
Disease	Hypertensive disease	MC2R BDKRB2 TLR4 SERPINE1 KNG1	3.45e-04	190	93	5	C0020538
Disease	familial Mediterranean fever (is_implicated_in)	TLR4 SERPINE1	3.49e-04	9	93	2	DOID:2987 (is_implicated_in)
Disease	abdominal aortic aneurysm (implicated_via_orthology)	SERPINE1 KNG1	3.49e-04	9	93	2	DOID:7693 (implicated_via_orthology)
Disease	dipeptidase 2 measurement	DPEP2 DPEP3	4.35e-04	10	93	2	EFO_0801528
Disease	sleep duration, high density lipoprotein cholesterol measurement	CMIP DPEP3 SCARB1 PCSK7	5.93e-04	121	93	4	EFO_0004612, EFO_0005271
Disease	asthma (is_marker_for)	BDKRB2 CD86 TLR4 SERPINE1	6.90e-04	126	93	4	DOID:2841 (is_marker_for)
Disease	Reactive Hyperemia	BDKRB2 KNG1	7.49e-04	13	93	2	C0178824
Disease	lung disease (implicated_via_orthology)	BDKRB2 TLR4	7.49e-04	13	93	2	DOID:850 (implicated_via_orthology)
Disease	Venous Engorgement	BDKRB2 KNG1	7.49e-04	13	93	2	C0042484
Disease	Active Hyperemia	BDKRB2 KNG1	7.49e-04	13	93	2	C0333233
Disease	Hyperemia	BDKRB2 KNG1	7.49e-04	13	93	2	C0020452
Disease	phospholipids:total lipids ratio	USP24 CMIP DPEP2 SCARB1 PCSK7	7.73e-04	227	93	5	EFO_0020946
Disease	high grade glioma (biomarker_via_orthology)	CAV2 BDKRB2	1.00e-03	15	93	2	DOID:3070 (biomarker_via_orthology)
Disease	renal fibrosis (implicated_via_orthology)	TLR4 SERPINE1	1.30e-03	17	93	2	DOID:0050855 (implicated_via_orthology)
Disease	asthma (is_implicated_in)	BDKRB2 CD86 TLR4 SERPINE1	1.56e-03	157	93	4	DOID:2841 (is_implicated_in)
Disease	alcohol consumption measurement, high density lipoprotein cholesterol measurement	CMIP DPEP2 DPEP3 SCARB1	1.75e-03	162	93	4	EFO_0004612, EFO_0007878
Disease	feeling "fed-up" measurement	LARS2 TLR4 PLCL2	1.80e-03	76	93	3	EFO_0009588
Disease	alcohol drinking, high density lipoprotein cholesterol measurement	CMIP DPEP2 DPEP3 SCARB1	2.00e-03	168	93	4	EFO_0004329, EFO_0004612
Disease	high density lipoprotein particle size measurement	NHLRC2 CMIP SCARB1 PCSK7	2.08e-03	170	93	4	EFO_0008592
Disease	Respiratory Hypersensitivity	TLR4 SERPINE1	2.18e-03	22	93	2	C0035228
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	USP24 NHLRC2 CMIP SCARB1 PCSK7	2.31e-03	291	93	5	EFO_0008317, EFO_0020946
Disease	primary open angle glaucoma (is_implicated_in)	CAV2 TLR4	2.38e-03	23	93	2	DOID:1070 (is_implicated_in)
Disease	sciatic neuropathy (implicated_via_orthology)	TLR4 SERPINE1	2.38e-03	23	93	2	DOID:11446 (implicated_via_orthology)
Disease	Behcet Syndrome	TLR4 SERPINE1	2.59e-03	24	93	2	C0004943
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	NHLRC2 CMIP SCARB1 ABCB11 PCSK7	2.75e-03	303	93	5	EFO_0004612, EFO_0020945
Disease	myeloid white cell count	RAD51B NHLRC2 SLC35D1 CMIP DPEP2 DSTYK RTCA SFXN2 ATP1A4	2.81e-03	937	93	9	EFO_0007988
Disease	acute necrotizing pancreatitis (biomarker_via_orthology)	TLR4 SERPINE1	3.04e-03	26	93	2	DOID:0080998 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLSVITFCTMQIMQV	BDKRB2	236	P30411
TPLMMACTRKNLGVI	ANKRD16	106	Q6P6B7
NCFPVLMGIVSNALM	ABCA10	891	Q8WWZ4
CIRAGLIFMPGTIQM	ACSM2A	126	Q08AH3
LVCLVSMDIQMFGPD	ARID2	446	Q68CP9
PCMLLALRGNQTMVE	CMIP	571	Q8IY22
QMALFIQRMTSTICG	ABCB11	216	O95342
MMSPSQASLLFLNVC	ANGPTL5	1	Q86XS5
MDPQCTMGLSNILFV	CD86	1	P42081
QFCIMMSILATLPTN	RAD51B	116	O15315
CLLLDANFTVVVMMP	NOL11	651	Q9H8H0
VRSQVDLPCGIMSQM	ANKAR	61	Q7Z5J8
MCPLTLHVTGLMNVS	OR11H2	1	Q8NH07
TMNNSRVVCGMLGFP	LOXL4	196	Q96JB6
LMMCQSTFLPQVEGT	MED13L	1201	Q71F56
SLMMLNPIGFIFCEI	GPR155	176	Q7Z3F1
TNLLIAQSIVCAGMM	GPR155	416	Q7Z3F1
SILIAGISLMCMNQT	GPR155	531	Q7Z3F1
PINSVLLFLMGMACA	SLC66A1	131	Q6ZP29
LLCTPVGLSRMFTVM	LMBR1	206	Q8WVP7
LAAGMIALMLQVRPC	PCSK7	411	Q16549
NTRFVMKTLMTICPG	KCNN3	446	Q9UGI6
QLSLMDLMLVCTNVP	OR2V2	66	Q96R30
SLCSMMIVDTPGFQN	MYO18A	781	Q92614
NQSVRLPLMECVQMT	PFKL	341	P17858
VVMGSIITMCLNSLP	KCNS2	196	Q9ULS6
FSLVKMPSLQPVVMC	NELFB	101	Q8WX92
SQMGTVQPIPCLLSM	FAM120A	521	Q9NZB2
PQGTVMLTSKNIQCM	MON2	666	Q7Z3U7
TVIMNPQLCTQMAIT	OR12D2	131	P58182
VLVRNCIQAMIDPSM	HUWE1	361	Q7Z6Z7
LRMQVSETCTGPMLQ	POF1B	436	Q8WVV4
IVQPMLQGIMNRLCK	DSTYK	901	Q6XUX3
CMMKAILFSQPLQIT	NHLRC2	696	Q8NBF2
TVIMNPQLCTQMAIT	OR12D1	131	P0DN82
CRLMISAGQLTLPME	LPCAT2	326	Q7L5N7
IIMSLQQPAIFCNMV	HSPBAP1	36	Q96EW2
NIANPTATLLASCMM	IDH3G	321	P51553
IVSTQPAMMVNLRAC	C2CD2L	246	O14523
ISMLVILLNCVTLGM	CACNA1G	86	O43497
SLAICMMTLPQQLEE	CPLANE1	1926	Q9H799
EIASMNITVPLAMFC	DNAH3	651	Q8TD57
FPEGTCINNTSVMMF	GPAT3	301	Q53EU6
LLATASQMQMVVLPC	IL24	21	Q13007
SQMQMVVLPCLGFTL	IL24	26	Q13007
QISPFISQMCNMLGL	GET3	196	O43681
MVSLSMGVIQCNPSA	DPEP2	311	Q9H4A9
LCQMIPVTGQSSMLP	KLF11	286	O14901
PTVNCQPLGMISLMK	KNG1	366	P01042
GIVMVTLSMGVLQCN	DPEP3	316	Q9H4B8
FVTMILQCSIEMPNI	DDX21	636	Q9NR30
MPFVKTCLMVLPSVQ	CAV2	116	P51636
VLTFILPCLMIPSQM	SLC22A11	21	Q9NSA0
IVSMCQIMTTAPRQG	CCDC184	86	Q52MB2
ITQPLMVCLMALGFA	PKD1L1	2181	Q8TDX9
LSMCLTIMVGQDGQV	GGT2P	451	P36268
ELLMVSNNGLVTLMC	OR4D5	196	Q8NGN0
MCPLTLQVTGLMNVS	OR11H1	1	Q8NG94
MCPLTLQVTGLMNVS	OR11H12	1	B2RN74
DTTPQTLMGFCIAMV	OR2AT4	196	A6NND4
MQMSPALTCLVLGLA	SERPINE1	1	P05121
STVMRPQVCALMLAL	OR1N1	131	Q8NGS0
QTVLTMMLPFCGNNV	OR13D1	191	Q8NGV5
LVTLNSGMMCVAIFL	OR4C6	196	Q8NH72
GTLCSMGMVQQLVAL	HSPBP1	266	Q9NZL4
FQVVISRICMAIPAM	SFXN3	226	Q9BWM7
LQVMLSGCFLIFMVP	SFXN2	266	Q96NB2
CLTPVMAVNMLTQQE	LARS2	341	Q15031
LDPIFGMMFELTCNI	FER1L5	1531	A0AVI2
SSVANLMQCMLAVSP	PLCL2	951	Q9UPR0
IPMALMTCFRLLQAV	KERA	336	O60938
TMMLIGTPTQADCFT	SIAH3	186	Q8IW03
CAVLGAVMIVMVPSL	SCARB1	21	Q8WTV0
IRPLMGMSLALQCQV	NHEJ1	136	Q9H9Q4
LGTRALQIAMCAPVM	POLR2F	66	P61218
LQIAMCAPVMVELEG	POLR2F	71	P61218
LLQFTLSCVMGFILM	SLC35D1	256	Q9NTN3
MTLVLSMNRFCEPIV	SERTAD4	1	Q9NUC0
PCPVTTDMTLQQVLM	RO60	421	P10155
ECTFPNTGARIMMFI	SEC23A	276	Q15436
VKVASNCPTGLFMVM	SLC22A18	246	Q96BI1
NCPTGLFMVMFSIIS	SLC22A18	251	Q96BI1
NMLLCVGASVMSILP	SERINC1	236	Q9NRX5
SLFQVNGMLIMCNAV	MC2R	256	Q01718
NGMLIMCNAVIDPFI	MC2R	261	Q01718
CIRAGLIFMPGTIQM	ACSM2B	126	Q68CK6
MDNLCFVGLISMIDP	ATP1A4	586	Q13733
MICEKMANPVQLGST	CLEC12A	246	Q5QGZ9
CFELTGQIAHILPMM	CLCN1	546	P35523
NFAGSVLRMVPCMVV	SLC49A3	106	Q6UXD7
NINLMGIAPICVMAK	ERVFRD-1	116	P60508
QDTVMLMSLPDVCQL	RFX8	206	Q6ZV50
LLMQVSMPCVLFAAS	RTCA	101	O00442
CVIMGVGTLLIAMPQ	SLCO1C1	116	Q9NYB5
VGTLLIAMPQFFMEQ	SLCO1C1	121	Q9NYB5
GLLQCNFLTMDSPMQ	PSME4	1711	Q14997
IMNETDLAGPMVFCL	YIPF5	121	Q969M3
TLFQPCNLMGAMQLI	YY1AP1	226	Q9H869
LPGVVMALVCNVFDM	USP24	1071	Q9UPU5
GLMMNLCLQAPFVSE	TTC12	501	Q9H892
NCFVVPMATGMSLTL	SEPSECS	136	Q9HD40
LFLPSMMPIGCVQLN	XPC	761	Q01831
QGMPVLSLNITCQMN	TLR4	616	O00206
VLCMDVGFTMSNSIP	XRCC5	11	P13010
LTSFRPQCSFMGMVI	UBR5	2166	O95071
SVVMCMGTIPELQVL	KCNF1	196	Q9H3M0
LMIGVFGCTLQVMQD	LRRC8C	36	Q8TDW0