Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	EOMES DMRTB1 GBX2 CDX2 ERG ASCL3 NFATC2 KLF1 HOXB13 IRX4 FOXC1 YLPM1 TBX2	2.83e-06	1412	41	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	EOMES WBP2 DMRTB1 GBX2 CDX2 ERG ASCL3 NFATC2 KLF1 HOXB13 IRX4 FOXC1 TBX2	4.07e-06	1459	41	13	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	EOMES WBP2 DMRTB1 CDX2 ERG NFATC2 KLF1 HOXB13 IRX4 FOXC1 TBX2	2.92e-05	1244	41	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	EOMES WBP2 DMRTB1 CDX2 ERG NFATC2 KLF1 HOXB13 IRX4 FOXC1 TBX2	3.56e-05	1271	41	11	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	CDX2 ASCL3 NFATC2 HOXB13 YLPM1 TBX2	4.53e-05	320	41	6	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	CDX2 ASCL3 NFATC2 HOXB13 YLPM1 TBX2	5.02e-05	326	41	6	GO:0001217
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	RAD54L2 ARID1A CECR2	5.95e-05	37	41	3	GO:0140658
GeneOntologyMolecularFunction	chromatin binding	EOMES WBP2 DDX17 ERG ARID1A NFATC2 NIPBL FOXC1	1.10e-04	739	41	8	GO:0003682
GeneOntologyMolecularFunction	transcription factor binding	EOMES WBP2 GBX2 ARID1A NFATC2 KLF1 FOXC1 TBX2	1.25e-04	753	41	8	GO:0008134
GeneOntologyMolecularFunction	transcription coregulator activity	WBP2 DDX17 ZMIZ1 RAD54L2 ARID1A NIPBL SS18L1	1.32e-04	562	41	7	GO:0003712
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	EOMES WBP2 GBX2 ARID1A KLF1 FOXC1 TBX2	1.64e-04	582	41	7	GO:0140297
GeneOntologyMolecularFunction	transcription coactivator activity	WBP2 DDX17 ZMIZ1 ARID1A SS18L1	3.73e-04	303	41	5	GO:0003713
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	EOMES WBP2 GBX2 ARID1A FOXC1	1.57e-03	417	41	5	GO:0061629
GeneOntologyMolecularFunction	methyl-CpG binding	CDX2 HOXB13	1.84e-03	31	41	2	GO:0008327
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	RAD54L2 ARID1A NIPBL CECR2	2.00e-03	262	41	4	GO:0140097
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	RAD54L2 ARID1A CECR2	2.25e-03	127	41	3	GO:0008094
GeneOntologyMolecularFunction	miRNA binding	PUM1 RC3H1	4.37e-03	48	41	2	GO:0035198
GeneOntologyMolecularFunction	chromatin DNA binding	EOMES WBP2 DDX17	4.85e-03	167	41	3	GO:0031490
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	GBX2 ERG NFATC2 KLF1 FOXC1	5.55e-03	560	41	5	GO:0001228
GeneOntologyMolecularFunction	molecular adaptor activity	WBP2 DDX17 ZMIZ1 RAD54L2 ARID1A NFATC2 NIPBL SS18L1	5.65e-03	1356	41	8	GO:0060090
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	GBX2 ERG NFATC2 KLF1 FOXC1	5.80e-03	566	41	5	GO:0001216
GeneOntologyMolecularFunction	regulatory RNA binding	PUM1 RC3H1	7.20e-03	62	41	2	GO:0061980
GeneOntologyMolecularFunction	ATP-dependent activity	DDX17 RAD54L2 ARID1A DNAH9 CECR2	8.12e-03	614	41	5	GO:0140657
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	WBP2 DDX17 ZMIZ1 RAD54L2 ARID1A NIPBL SS18L1	8.69e-03	1160	41	7	GO:0030674
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DDX17 RAD54L2 ARID1A NIPBL CECR2	9.93e-03	645	41	5	GO:0140640
GeneOntologyMolecularFunction	promoter-specific chromatin binding	NIPBL FOXC1	1.26e-02	83	41	2	GO:1990841
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	EOMES WBP2 GBX2 CDX2 DDX17 ZMIZ1 RAD54L2 ERG ASCL3 NFATC2 KLF1 NIPBL SS18L1 FOXC1 TBX2	2.98e-08	1390	41	15	GO:0045944
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	EOMES CDX2 ARID1A ZNF608 ASCL3 NFATC2 NIPBL HOXB13 IRX4 FOXC1 YLPM1 TBX2	5.87e-07	1053	41	12	GO:0000122
GeneOntologyBiologicalProcess	chordate embryonic development	EOMES GBX2 CDX2 ZMIZ1 ARID1A KLF1 NIPBL CECR2 FOXC1 TBX2	8.24e-06	906	41	10	GO:0043009
GeneOntologyBiologicalProcess	embryo development ending in birth or egg hatching	EOMES GBX2 CDX2 ZMIZ1 ARID1A KLF1 NIPBL CECR2 FOXC1 TBX2	1.03e-05	929	41	10	GO:0009792
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	EOMES CDX2 ARID1A ZNF608 ASCL3 NFATC2 NIPBL HOXB13 IRX4 FOXC1 YLPM1 TBX2	1.13e-05	1399	41	12	GO:0045892
GeneOntologyBiologicalProcess	embryonic organ development	EOMES GBX2 CDX2 ARID1A KLF1 NIPBL FOXC1 TBX2	1.23e-05	561	41	8	GO:0048568
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	EOMES CDX2 ARID1A ZNF608 ASCL3 NFATC2 NIPBL HOXB13 IRX4 FOXC1 YLPM1 TBX2	1.25e-05	1413	41	12	GO:1902679
GeneOntologyBiologicalProcess	stem cell differentiation	EOMES GBX2 CDX2 PUM1 FOXC1 TBX2	2.95e-05	306	41	6	GO:0048863
GeneOntologyBiologicalProcess	cellular response to steroid hormone stimulus	WBP2 DDX17 ZMIZ1 ARID1A TBX2	1.07e-04	239	41	5	GO:0071383
GeneOntologyBiologicalProcess	androgen receptor signaling pathway	DDX17 ZMIZ1 ARID1A	1.42e-04	51	41	3	GO:0030521
GeneOntologyBiologicalProcess	nuclear receptor-mediated steroid hormone signaling pathway	WBP2 DDX17 ZMIZ1 ARID1A	1.52e-04	136	41	4	GO:0030518
GeneOntologyBiologicalProcess	establishment of protein localization to chromatin	WBP2 NIPBL	1.72e-04	10	41	2	GO:0071169
GeneOntologyBiologicalProcess	estrogen receptor signaling pathway	WBP2 DDX17 ARID1A	1.98e-04	57	41	3	GO:0030520
GeneOntologyBiologicalProcess	steroid hormone receptor signaling pathway	WBP2 DDX17 ZMIZ1 ARID1A	2.50e-04	155	41	4	GO:0043401
GeneOntologyBiologicalProcess	chromatin organization	EOMES WBP2 RAD54L2 ARID1A KLF1 NIPBL CECR2 SS18L1	3.28e-04	896	41	8	GO:0006325
GeneOntologyBiologicalProcess	embryo development	EOMES GBX2 CDX2 ZMIZ1 ARID1A KLF1 NIPBL CECR2 FOXC1 TBX2	3.98e-04	1437	41	10	GO:0009790
GeneOntologyBiologicalProcess	circulatory system development	EOMES GBX2 CDX2 ZMIZ1 ARID1A NFATC2 NIPBL IRX4 FOXC1 TBX2	4.09e-04	1442	41	10	GO:0072359
GeneOntologyBiologicalProcess	embryonic morphogenesis	EOMES GBX2 ARID1A NIPBL CECR2 FOXC1 TBX2	4.62e-04	713	41	7	GO:0048598
GeneOntologyBiologicalProcess	pattern specification process	EOMES GBX2 CDX2 IRX4 FOXC1 TBX2	5.63e-04	526	41	6	GO:0007389
GeneOntologyBiologicalProcess	cardioblast differentiation	EOMES TBX2	5.78e-04	18	41	2	GO:0010002
GeneOntologyBiologicalProcess	chromatin remodeling	EOMES WBP2 RAD54L2 ARID1A KLF1 NIPBL CECR2	5.81e-04	741	41	7	GO:0006338
GeneOntologyBiologicalProcess	tissue morphogenesis	EOMES GBX2 ARID1A HOXB13 CECR2 FOXC1 TBX2	6.25e-04	750	41	7	GO:0048729
GeneOntologyBiologicalProcess	3'-UTR-mediated mRNA destabilization	PUM1 RC3H1	6.45e-04	19	41	2	GO:0061158
GeneOntologyBiologicalProcess	heart development	EOMES ZMIZ1 ARID1A NIPBL IRX4 FOXC1 TBX2	6.60e-04	757	41	7	GO:0007507
GeneOntologyBiologicalProcess	protein-DNA complex organization	EOMES WBP2 RAD54L2 ARID1A KLF1 NIPBL CECR2 SS18L1	6.76e-04	999	41	8	GO:0071824
GeneOntologyBiologicalProcess	nuclear receptor-mediated signaling pathway	WBP2 DDX17 ZMIZ1 ARID1A	6.81e-04	202	41	4	GO:0141193
GeneOntologyBiologicalProcess	animal organ morphogenesis	GBX2 CDX2 ZMIZ1 ARID1A NIPBL HOXB13 IRX4 FOXC1 TBX2	7.17e-04	1269	41	9	GO:0009887
GeneOntologyBiologicalProcess	muscle tissue development	EOMES FLNB DDX17 ARID1A FOXC1 TBX2	7.67e-04	558	41	6	GO:0060537
GeneOntologyBiologicalProcess	artery morphogenesis	ZMIZ1 FOXC1 TBX2	8.10e-04	92	41	3	GO:0048844
GeneOntologyBiologicalProcess	mesenchyme development	EOMES GBX2 DDX17 FOXC1 TBX2	8.16e-04	372	41	5	GO:0060485
GeneOntologyBiologicalProcess	outflow tract morphogenesis	NIPBL FOXC1 TBX2	8.62e-04	94	41	3	GO:0003151
GeneOntologyBiologicalProcess	response to steroid hormone	WBP2 DDX17 ZMIZ1 ARID1A TBX2	9.09e-04	381	41	5	GO:0048545
GeneOntologyBiologicalProcess	T cell differentiation	EOMES ZMIZ1 ARID1A ZNF608 RC3H1	9.19e-04	382	41	5	GO:0030217
GeneOntologyBiologicalProcess	regulation of T cell differentiation	ZMIZ1 ARID1A ZNF608 RC3H1	1.03e-03	226	41	4	GO:0045580
GeneOntologyBiologicalProcess	trophectodermal cell differentiation	EOMES CDX2	1.22e-03	26	41	2	GO:0001829
GeneOntologyBiologicalProcess	erythrocyte maturation	KLF1 MAEA	1.22e-03	26	41	2	GO:0043249
GeneOntologyBiologicalProcess	stem cell population maintenance	EOMES CDX2 ARID1A NIPBL	1.23e-03	237	41	4	GO:0019827
GeneOntologyBiologicalProcess	maintenance of cell number	EOMES CDX2 ARID1A NIPBL	1.33e-03	242	41	4	GO:0098727
GeneOntologyBiologicalProcess	intracellular receptor signaling pathway	WBP2 DDX17 ZMIZ1 ARID1A PUM1	1.34e-03	416	41	5	GO:0030522
GeneOntologyBiologicalProcess	muscle structure development	EOMES FLNB DDX17 ARID1A NFATC2 FOXC1 TBX2	1.37e-03	858	41	7	GO:0061061
GeneOntologyBiologicalProcess	hormone-mediated signaling pathway	WBP2 DDX17 ZMIZ1 ARID1A	1.37e-03	244	41	4	GO:0009755
GeneOntologyBiologicalProcess	establishment of protein localization to chromosome	WBP2 NIPBL	1.51e-03	29	41	2	GO:0070199
GeneOntologyBiologicalProcess	forebrain neuron development	GBX2 ZMIZ1	1.62e-03	30	41	2	GO:0021884
GeneOntologyCellularComponent	chromatin	EOMES WBP2 DMRTB1 GBX2 CDX2 ZMIZ1 ERG ARID1A ASCL3 NFATC2 KLF1 NIPBL HOXB13 CECR2 IRX4 SS18L1 FOXC1 TBX2	7.59e-11	1480	41	18	GO:0000785
GeneOntologyCellularComponent	nBAF complex	ARID1A SS18L1	4.43e-04	16	41	2	GO:0071565
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	ARID1A CECR2 SS18L1	8.82e-04	96	41	3	GO:0070603
GeneOntologyCellularComponent	transcription regulator complex	CDX2 ASCL3 NFATC2 HOXB13 IRX4 TBX2	1.01e-03	596	41	6	GO:0005667
GeneOntologyCellularComponent	P-body	UBAP2 PUM1 RC3H1	1.05e-03	102	41	3	GO:0000932
GeneOntologyCellularComponent	ATPase complex	ARID1A CECR2 SS18L1	2.06e-03	129	41	3	GO:1904949
MousePheno	abnormal pharyngeal arch artery morphology	GBX2 ZMIZ1 FOXC1 TBX2	5.44e-06	47	35	4	MP:0002672
MousePheno	abnormal artery development	FLNB GBX2 ZMIZ1 FOXC1 TBX2	1.87e-05	133	35	5	MP:0003410
MousePheno	abnormal embryonic tissue morphology	EOMES GBX2 ZMIZ1 RAD54L2 ARID1A HOXB13 CECR2 RC3H1 FOXC1 YLPM1 TBX2	5.56e-05	1116	35	11	MP:0002085
MousePheno	decreased radius size	FLNB NIPBL FOXC1	1.33e-04	40	35	3	MP:0030886
MousePheno	short radius	FLNB NIPBL FOXC1	1.33e-04	40	35	3	MP:0004355
MousePheno	abnormal trophoblast layer morphology	EOMES CDX2 RAD54L2 ARID1A NIPBL	1.68e-04	211	35	5	MP:0005031
MousePheno	thin ribs	FLNB FOXC1	2.17e-04	9	35	2	MP:0004674
MousePheno	abnormal choroid plexus morphology	GBX2 PDCD6IP FOXC1	2.30e-04	48	35	3	MP:0000820
MousePheno	abnormal tela choroidea morphology	GBX2 PDCD6IP FOXC1	2.30e-04	48	35	3	MP:0013306
MousePheno	abnormal angiogenesis	FLNB GBX2 ZMIZ1 ERG FOXC1 TBX2	2.88e-04	372	35	6	MP:0000260
MousePheno	delayed endochondral bone ossification	FLNB NIPBL FOXC1	3.27e-04	54	35	3	MP:0003419
MousePheno	decreased trophoblast giant cell number	EOMES CDX2 RAD54L2	3.27e-04	54	35	3	MP:0001713
MousePheno	abnormal vascular development	FLNB GBX2 ZMIZ1 ERG ARID1A FOXC1 TBX2	3.31e-04	542	35	7	MP:0000259
Domain	p53-like_TF_DNA-bd	EOMES NFATC2 TBX2	1.98e-04	53	40	3	IPR008967
Domain	TF_T-box	EOMES TBX2	5.96e-04	17	40	2	IPR001699
Domain	TBOX_3	EOMES TBX2	5.96e-04	17	40	2	PS50252
Domain	TBOX	EOMES TBX2	5.96e-04	17	40	2	SM00425
Domain	TF_T-box_CS	EOMES TBX2	5.96e-04	17	40	2	IPR018186
Domain	T-box	EOMES TBX2	5.96e-04	17	40	2	PF00907
Domain	-	EOMES TBX2	5.96e-04	17	40	2	2.60.40.820
Domain	TBOX_1	EOMES TBX2	5.96e-04	17	40	2	PS01283
Domain	TBOX_2	EOMES TBX2	5.96e-04	17	40	2	PS01264
Domain	Homeobox_CS	GBX2 CDX2 HOXB13 IRX4	6.58e-04	186	40	4	IPR017970
Domain	Homeobox	GBX2 CDX2 HOXB13 IRX4	1.54e-03	234	40	4	PF00046
Domain	HOMEOBOX_1	GBX2 CDX2 HOXB13 IRX4	1.59e-03	236	40	4	PS00027
Domain	HOX	GBX2 CDX2 HOXB13 IRX4	1.61e-03	237	40	4	SM00389
Domain	Homeobox_dom	GBX2 CDX2 HOXB13 IRX4	1.66e-03	239	40	4	IPR001356
Domain	HOMEOBOX_2	GBX2 CDX2 HOXB13 IRX4	1.66e-03	239	40	4	PS50071
Domain	-	GBX2 CDX2 HOXB13 IRX4	3.07e-03	283	40	4	1.10.10.60
Domain	Homeodomain-like	GBX2 CDX2 HOXB13 IRX4	5.41e-03	332	40	4	IPR009057
Domain	-	ARID1A PUM1 NIPBL	1.18e-02	222	40	3	1.25.10.10
Pathway	WP_HEART_DEVELOPMENT	NFATC2 IRX4 FOXC1 TBX2	1.92e-06	46	28	4	MM15884
Pathway	WP_HEART_DEVELOPMENT	NFATC2 IRX4 FOXC1 TBX2	2.09e-06	47	28	4	M39610
Pathway	REACTOME_POU5F1_OCT4_SOX2_NANOG_REPRESS_GENES_RELATED_TO_DIFFERENTIATION	EOMES CDX2	1.70e-04	10	28	2	M27208
Pubmed	A census of human transcription factors: function, expression and evolution.	EOMES DMRTB1 GBX2 CDX2 ERG ASCL3 NFATC2 KLF1 HOXB13 IRX4 FOXC1 TBX2	3.67e-10	908	41	12	19274049
Pubmed	Human transcription factor protein interaction networks.	UBAP2 ZMIZ1 RAD54L2 ERG ARID1A PUM1 ZNF608 NIPBL RC3H1 SS18L1 FOXC1 EIF3L YLPM1	5.42e-09	1429	41	13	35140242
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	UBAP2 DDX17 FAM168A ARID1A PUM1 NIPBL SS18L1 FOXC1 EIF3L YLPM1	1.19e-07	954	41	10	36373674
Pubmed	Interaction network of human early embryonic transcription factors.	ZMIZ1 RAD54L2 ARID1A ZNF608 NIPBL SS18L1 TBX2	1.68e-07	351	41	7	38297188
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	EOMES GBX2 CDX2 ZMIZ1 KLF1 FOXC1 TBX2	5.99e-07	424	41	7	21731673
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	WBP2 UBAP2 DDX17 ARID1A YLPM1	1.05e-06	154	41	5	16055720
Pubmed	Roles of CDX2 and EOMES in human induced trophoblast progenitor cells.	EOMES CDX2	1.36e-06	2	41	2	23313847
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	ARID1A ZNF608 NIPBL FOXC1	2.85e-06	83	41	4	28794006
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	EOMES GBX2 CDX2 HOXB13 TBX2	3.03e-06	191	41	5	24146773
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	EOMES GBX2 CDX2 ERG NFATC2 HOXB13 TBX2	3.13e-06	544	41	7	28473536
Pubmed	Somatic molecular subtyping of prostate tumors from HOXB13 G84E carriers.	ERG HOXB13	4.06e-06	3	41	2	28186998
Pubmed	The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.	EOMES GBX2 CDX2	4.88e-06	28	41	3	28839193
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	WBP2 UBAP2 DDX17 RC3H1 YLPM1	6.02e-06	220	41	5	24550385
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	DDX17 ERG ARID1A HOXB13 YLPM1	6.02e-06	220	41	5	35785414
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	WBP2 UBAP2 DDX17 FAM168A ARID1A RC3H1 EIF3L	6.97e-06	615	41	7	31048545
Pubmed	Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.	GBX2 FOXC1 TBX2	8.09e-06	33	41	3	24705356
Pubmed	Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo.	EOMES CDX2	8.12e-06	4	41	2	18067887
Pubmed	Novel key roles for structural maintenance of chromosome flexible domain containing 1 (Smchd1) during preimplantation mouse development.	EOMES CDX2	8.12e-06	4	41	2	29900695
Pubmed	Developmental abnormalities of NT mouse embryos appear early after implantation.	EOMES CDX2	8.12e-06	4	41	2	16556918
Pubmed	Dynamic Changes of Gene Expression in Mouse Mural Trophectoderm Regulated by Cdx2 During Implantation.	EOMES CDX2	8.12e-06	4	41	2	36051443
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNB PDCD6IP ARID1A PUM1 NIPBL EIF3L YLPM1	1.03e-05	653	41	7	22586326
Pubmed	Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.	NIPBL IRX4 TBX2	1.06e-05	36	41	3	27606604
Pubmed	Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.	EOMES CDX2	1.35e-05	5	41	2	18836439
Pubmed	Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells.	EOMES TBX2	1.35e-05	5	41	2	10970091
Pubmed	Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.	EOMES CDX2	1.35e-05	5	41	2	16325584
Pubmed	Global proteomics of Ubqln2-based murine models of ALS.	WBP2 FLNB PDCD6IP FAM222B EIF3L	1.38e-05	261	41	5	33277362
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	ZMIZ1 ARID1A PUM1 RC3H1 FAM222B YLPM1	1.52e-05	457	41	6	32344865
Pubmed	Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen.	EOMES TBX2	2.03e-05	6	41	2	21509901
Pubmed	Pax9 and Gbx2 Interact in the Pharyngeal Endoderm to Control Cardiovascular Development.	GBX2 ERG	2.03e-05	6	41	2	32466118
Pubmed	Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis.	CDX2 PUM1	2.03e-05	6	41	2	32198202
Pubmed	KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2.	EOMES CDX2	2.03e-05	6	41	2	38961108
Pubmed	Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.	EOMES CDX2	2.84e-05	7	41	2	20081188
Pubmed	Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells.	EOMES CDX2	2.84e-05	7	41	2	24120664
Pubmed	Primate gastrulation and early organogenesis at single-cell resolution.	EOMES CDX2	2.84e-05	7	41	2	36517595
Pubmed	CoupTFI interacts with retinoic acid signaling during cortical development.	EOMES FOXC1	2.84e-05	7	41	2	23472160
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ZMIZ1 ZNF608 RC3H1 FAM222B	3.13e-05	152	41	4	38360978
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	FLNB UBAP2 PDCD6IP PUM1 EIF3L	3.39e-05	315	41	5	26777405
Pubmed	A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family.	EOMES TBX2	3.78e-05	8	41	2	9503012
Pubmed	Intermediate Progenitors Facilitate Intracortical Progression of Thalamocortical Axons and Interneurons through CXCL12 Chemokine Signaling.	EOMES GBX2	3.78e-05	8	41	2	26400936
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	FLNB DDX17 PUM1 RC3H1 EIF3L YLPM1 ALG13	3.99e-05	807	41	7	22681889
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FLNB UBAP2 DDX17 MAEA EIF3L ALG13	4.32e-05	551	41	6	34728620
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	FLNB DDX17 RAD54L2 PDCD6IP NIPBL	4.35e-05	332	41	5	32786267
Pubmed	PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.	EOMES CDX2 FOXC1	4.72e-05	59	41	3	38374152
Pubmed	Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development.	EOMES CDX2	4.86e-05	9	41	2	17913785
Pubmed	Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.	EOMES CDX2	4.86e-05	9	41	2	24448552
Pubmed	Alix is required during development for normal growth of the mouse brain.	EOMES PDCD6IP	4.86e-05	9	41	2	28322231
Pubmed	The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice.	EOMES CDX2	4.86e-05	9	41	2	32244352
Pubmed	Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.	FLNB PDCD6IP EIF3L	6.31e-05	65	41	3	34645483
Pubmed	Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.	EOMES ARID1A SS18L1	6.31e-05	65	41	3	26655900
Pubmed	Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.	RAD54L2 HOXB13 MAEA	7.23e-05	68	41	3	36966392
Pubmed	Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.	EOMES CDX2	7.41e-05	11	41	2	12015300
Pubmed	Functional selectivity of recombinant mammalian SWI/SNF subunits.	ARID1A KLF1	7.41e-05	11	41	2	11018012
Pubmed	Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.	EOMES CDX2	7.41e-05	11	41	2	18794365
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	EOMES CDX2	7.41e-05	11	41	2	37012455
Pubmed	Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis.	GBX2 ERG	7.41e-05	11	41	2	31444215
Pubmed	Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst.	EOMES CDX2	8.88e-05	12	41	2	15788452
Pubmed	Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2.	IRX4 TBX2	8.88e-05	12	41	2	17259303
Pubmed	ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.	CDX2 ARID1A	8.88e-05	12	41	2	18448678
Pubmed	Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm.	EOMES CDX2	8.88e-05	12	41	2	12748966
Pubmed	Spatiotemporal regulation of GLI target genes in the mammalian limb bud.	EOMES ZMIZ1 TBX2 ALG13	1.04e-04	207	41	4	26238476
Pubmed	Retinoic acid from the meninges regulates cortical neuron generation.	EOMES FOXC1	1.05e-04	13	41	2	19879845
Pubmed	Borcs6 is required for endo-lysosomal degradation during early development.	EOMES CDX2	1.05e-04	13	41	2	35726782
Pubmed	Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment.	EOMES CDX2	1.05e-04	13	41	2	22529382
Pubmed	Analysis of transcription factors expressed at the anterior mouse limb bud.	EOMES GBX2	1.05e-04	13	41	2	28467430
Pubmed	The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina.	EOMES ERG	1.05e-04	13	41	2	29053761
Pubmed	Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner.	EOMES CDX2	1.22e-04	14	41	2	25446535
Pubmed	A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.	EOMES CDX2	1.22e-04	14	41	2	23788624
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	DDX17 FAM168A ARID1A NIPBL CECR2	1.39e-04	425	41	5	24999758
Pubmed	Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.	ARID1A SS18L1	1.41e-04	15	41	2	23785148
Pubmed	Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis.	GBX2 HOXB13	1.41e-04	15	41	2	18304314
Pubmed	GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst.	EOMES CDX2	1.41e-04	15	41	2	24835466
Pubmed	Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice.	EOMES CDX2	1.41e-04	15	41	2	38113263
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	WBP2 UBAP2 RAD54L2 PDCD6IP YLPM1	1.47e-04	430	41	5	35044719
Pubmed	Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway.	EOMES FLNB	1.61e-04	16	41	2	27789627
Pubmed	Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes.	CDX2 HOXB13	1.61e-04	16	41	2	30661984
Pubmed	Bone morphogenic protein signaling is a major determinant of dentate development.	EOMES FOXC1	1.61e-04	16	41	2	23595735
Pubmed	Differential expression of the Tmem132 family genes in the developing mouse nervous system.	EOMES GBX2	1.61e-04	16	41	2	35690356
Pubmed	A balanced Oct4 interactome is crucial for maintaining pluripotency.	EOMES CDX2	1.61e-04	16	41	2	35171666
Pubmed	Pluripotency factors regulate definitive endoderm specification through eomesodermin.	EOMES FOXC1	1.61e-04	16	41	2	21245162
Pubmed	Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.	CDX2 HOXB13	1.61e-04	16	41	2	21752936
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	SCP2 WBP2 FLNB UBAP2 DDX17 PDCD6IP ARID1A YLPM1	1.68e-04	1367	41	8	32687490
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNB DDX17 PDCD6IP PUM1 NIPBL FOXC1 YLPM1	1.76e-04	1024	41	7	24711643
Pubmed	Loss of Twist1 and balanced retinoic acid signaling from the meninges causes cortical folding in mice.	EOMES FOXC1	1.82e-04	17	41	2	37590085
Pubmed	A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.	IRX4 TBX2	1.82e-04	17	41	2	11572777
Pubmed	Compartmentalized metabolism supports midgestation mammalian development.	EOMES CDX2	1.82e-04	17	41	2	35388219
Pubmed	Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm.	EOMES CDX2	2.05e-04	18	41	2	28401892
Pubmed	Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.	EOMES CDX2	2.05e-04	18	41	2	31260508
Pubmed	Intrauterine Pressures Adjusted by Reichert's Membrane Are Crucial for Early Mouse Morphogenesis.	EOMES CDX2	2.05e-04	18	41	2	32433954
Pubmed	WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.	WBP2 DDX17 FAM168A	2.08e-04	97	41	3	25071155
Pubmed	Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium.	IRX4 TBX2	2.29e-04	19	41	2	20651287
Pubmed	Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.	EOMES CDX2	2.29e-04	19	41	2	35988542
Pubmed	Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2.	GBX2 CDX2	2.29e-04	19	41	2	17493606
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	FLNB UBAP2 DDX17 PDCD6IP EIF3L	2.37e-04	477	41	5	31300519
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FLNB DDX17 RAD54L2 ARID1A SPAG17 ZNF608 NIPBL YLPM1	2.41e-04	1442	41	8	35575683
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DDX17 PDCD6IP ARID1A NIPBL CECR2 SS18L1 YLPM1	2.47e-04	1082	41	7	38697112
Pubmed	An epigenetic circuit controls neurogenic programs during neocortex development.	EOMES ARID1A	2.54e-04	20	41	2	35020876
Pubmed	MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome.	FOXC1 TBX2	2.54e-04	20	41	2	22921202
Pubmed	Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.	EOMES CDX2	2.54e-04	20	41	2	15829518
Pubmed	Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.	CDX2 HOXB13	2.54e-04	20	41	2	19853565
Pubmed	HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst.	EOMES CDX2	2.54e-04	20	41	2	25340657
Interaction	TLE3 interactions	DDX17 ZMIZ1 RAD54L2 ERG ARID1A ZNF608 NIPBL CECR2 FOXC1 ALG13	3.04e-09	376	41	10	int:TLE3
Interaction	SMARCC2 interactions	DDX17 ERG ARID1A NFATC2 KLF1 SS18L1 FOXC1 YLPM1	4.72e-07	353	41	8	int:SMARCC2
Interaction	IRF4 interactions	ARID1A ZNF608 NFATC2 NIPBL HOXB13	7.88e-07	85	41	5	int:IRF4
Interaction	SMARCC1 interactions	VGLL3 ERG ARID1A NFATC2 KLF1 RC3H1 SS18L1 YLPM1	8.91e-07	384	41	8	int:SMARCC1
Interaction	PRRC2B interactions	DMRTB1 ERG PUM1 CECR2 RC3H1 EIF3L ALG13	9.64e-07	265	41	7	int:PRRC2B
Interaction	ARID1A interactions	ERG ARID1A NFATC2 KLF1 SS18L1 FOXC1 ALG13	1.26e-06	276	41	7	int:ARID1A
Interaction	SMARCE1 interactions	FAM217B ERG ARID1A NFATC2 KLF1 SS18L1 FOXC1	1.64e-06	287	41	7	int:SMARCE1
Interaction	ALG13 interactions	DMRTB1 ARID1A PUM1 ZNF608 RC3H1 ALG13	1.78e-06	183	41	6	int:ALG13
Interaction	SMARCD2 interactions	ERG FAM168A ARID1A NFATC2 SS18L1 FOXC1	1.78e-06	183	41	6	int:SMARCD2
Interaction	EP300 interactions	CDX2 DDX17 ERG ARID1A PUM1 NFATC2 KLF1 SS18L1 FOXC1 EIF3L YLPM1 TBX2 ALG13	2.35e-06	1401	41	13	int:EP300
Interaction	SP7 interactions	ZMIZ1 ARID1A ZNF608 NIPBL SS18L1 FOXC1 YLPM1	2.40e-06	304	41	7	int:SP7
Interaction	PAX8 interactions	WBP2 ARID1A ZNF608 NIPBL SS18L1	2.96e-06	111	41	5	int:PAX8
Interaction	FEV interactions	RAD54L2 ARID1A ZNF608 NIPBL SS18L1 FOXC1	3.25e-06	203	41	6	int:FEV
Interaction	TBXT interactions	ARID1A ZNF608 NIPBL SS18L1 FOXC1	3.68e-06	116	41	5	int:TBXT
Interaction	ERG interactions	RAD54L2 ERG ARID1A ZNF608 NIPBL SS18L1	5.58e-06	223	41	6	int:ERG
Interaction	FAM168B interactions	VGLL3 UBAP2 FAM168A FAM222B	5.78e-06	58	41	4	int:FAM168B
Interaction	SMARCD1 interactions	CDX2 ERG FAM168A ARID1A NFATC2 KLF1 SS18L1	5.96e-06	349	41	7	int:SMARCD1
Interaction	R3HDM2 interactions	UBAP2 FAM168A PUM1 RC3H1 ALG13	6.19e-06	129	41	5	int:R3HDM2
Interaction	VPS37C interactions	UBAP2 PDCD6IP FAM168A ASCL3 KLF1	9.55e-06	141	41	5	int:VPS37C
Interaction	ATXN1L interactions	RAD54L2 ERG FAM168A TBX2 ALG13	1.29e-05	150	41	5	int:ATXN1L
Interaction	HNF4A interactions	RAD54L2 ARID1A ZNF608 NIPBL SS18L1 FOXC1	1.84e-05	275	41	6	int:HNF4A
Interaction	NUP35 interactions	ZMIZ1 PDCD6IP ARID1A PUM1 RC3H1 FAM222B YLPM1	2.10e-05	424	41	7	int:NUP35
Interaction	DDX17 interactions	WBP2 DDX17 NIPBL RC3H1 FOXC1 MAEA YLPM1	2.17e-05	426	41	7	int:DDX17
Interaction	FXR2 interactions	DMRTB1 UBAP2 DDX17 RAD54L2 PUM1 CECR2 RC3H1	2.30e-05	430	41	7	int:FXR2
Interaction	SMC5 interactions	UBAP2 DDX17 FAM168A ARID1A PUM1 NIPBL SS18L1 FOXC1 EIF3L YLPM1	2.38e-05	1000	41	10	int:SMC5
Interaction	EGR2 interactions	RAD54L2 ARID1A ZNF608 NIPBL SS18L1	2.43e-05	171	41	5	int:EGR2
Interaction	DLX5 interactions	CDX2 HOXB13 FOXC1	2.75e-05	29	41	3	int:DLX5
Interaction	TEAD1 interactions	VGLL3 ARID1A ZNF608 NIPBL FOXC1	2.79e-05	176	41	5	int:TEAD1
Interaction	ARID1B interactions	ERG FAM168A ARID1A SS18L1 ALG13	2.86e-05	177	41	5	int:ARID1B
Interaction	YTHDF1 interactions	DMRTB1 UBAP2 FAM168A PUM1 RC3H1 ALG13	3.12e-05	302	41	6	int:YTHDF1
Interaction	SMARCA4 interactions	CDX2 ERG ARID1A NFATC2 KLF1 SS18L1 FOXC1	3.64e-05	462	41	7	int:SMARCA4
Interaction	FBL interactions	CDX2 UBAP2 DDX17 ERG PUM1 RC3H1 FOXC1 ALG13	3.70e-05	639	41	8	int:FBL
Interaction	ATN1 interactions	RAD54L2 PDCD6IP ZNF608 SS18L1 ALG13	3.73e-05	187	41	5	int:ATN1
Interaction	WWP2 interactions	WBP2 UBAP2 DDX17 PDCD6IP FAM168A ARID1A RC3H1 EIF3L YLPM1	3.83e-05	840	41	9	int:WWP2
Interaction	SMAP2 interactions	UBAP2 FAM168A PUM1 RC3H1 ALG13	3.92e-05	189	41	5	int:SMAP2
Interaction	SMG7 interactions	ARID1A PUM1 ZNF608 RC3H1 YLPM1 ALG13	4.23e-05	319	41	6	int:SMG7
Interaction	MYOD1 interactions	ARID1A ZNF608 ASCL3 NIPBL SS18L1	4.44e-05	194	41	5	int:MYOD1
Interaction	RUNX1 interactions	WBP2 DDX17 ARID1A NFATC2 FAM222B FOXC1	4.61e-05	324	41	6	int:RUNX1
Interaction	SS18L1 interactions	ERG FAM168A ARID1A SS18L1	4.64e-05	98	41	4	int:SS18L1
Interaction	EOMES interactions	EOMES CDX2	6.03e-05	6	41	2	int:EOMES
Interaction	RBPMS interactions	DMRTB1 VGLL3 UBAP2 RAD54L2 FAM168A ALG13	6.03e-05	340	41	6	int:RBPMS
Interaction	RBMS1 interactions	SCP2 UBAP2 PUM1 RC3H1 ALG13	6.04e-05	207	41	5	int:RBMS1
Interaction	SMARCD3 interactions	ERG FAM168A ARID1A SS18L1	6.54e-05	107	41	4	int:SMARCD3
Interaction	PRMT1 interactions	FLNB UBAP2 DDX17 PUM1 FOXC1 MAEA EIF3L YLPM1 ALG13	8.36e-05	929	41	9	int:PRMT1
Interaction	BAG4 interactions	DMRTB1 RC3H1 FAM222B SS18L1 ALG13	8.78e-05	224	41	5	int:BAG4
Interaction	PAX6 interactions	CDX2 ARID1A ZNF608 NIPBL SS18L1 FOXC1	9.05e-05	366	41	6	int:PAX6
Interaction	EYA2 interactions	DMRTB1 ARID1A PUM1 LGALS4	1.05e-04	121	41	4	int:EYA2
Interaction	ZCCHC24 interactions	PUM1 RC3H1	1.12e-04	8	41	2	int:ZCCHC24
Interaction	PAX7 interactions	ARID1A ZNF608 SS18L1 FOXC1	1.16e-04	124	41	4	int:PAX7
Interaction	MEX3A interactions	FLNB CDX2 DDX17 ARID1A PUM1 RC3H1	1.18e-04	384	41	6	int:MEX3A
Interaction	LARP4B interactions	DMRTB1 UBAP2 PUM1 RC3H1 ALG13	1.21e-04	240	41	5	int:LARP4B
Interaction	SFPQ interactions	SCP2 DMRTB1 DDX17 ERG RC3H1 FOXC1 YLPM1	1.26e-04	563	41	7	int:SFPQ
Interaction	YTHDF3 interactions	DMRTB1 UBAP2 PUM1 RC3H1 ALG13	1.36e-04	246	41	5	int:YTHDF3
Interaction	AR interactions	DDX17 ZMIZ1 RAD54L2 ERG ARID1A ZNF608 NIPBL HOXB13 YLPM1	1.38e-04	992	41	9	int:AR
Interaction	PAX9 interactions	ARID1A ZNF608 NIPBL FOXC1	1.39e-04	130	41	4	int:PAX9
Interaction	CRX interactions	ZMIZ1 ARID1A ZNF608 NIPBL SS18L1	1.58e-04	254	41	5	int:CRX
Interaction	CEBPE interactions	NFATC2 FOXC1 TBX2	1.80e-04	54	41	3	int:CEBPE
Interaction	CREBBP interactions	CDX2 DDX17 ERG ARID1A NFATC2 KLF1 SS18L1	1.85e-04	599	41	7	int:CREBBP
Interaction	NFIB interactions	ERG ARID1A ZNF608 FOXC1	1.95e-04	142	41	4	int:NFIB
Interaction	FAM168A interactions	WBP2 FAM168A RC3H1 SS18L1	1.95e-04	142	41	4	int:FAM168A
Interaction	ATXN1 interactions	FLNB UBAP2 DDX17 RAD54L2 ERG PDCD6IP FAM168A ARID1A PUM1	1.95e-04	1039	41	9	int:ATXN1
Interaction	DAZL interactions	UBAP2 PUM1 RC3H1 ALG13	2.12e-04	145	41	4	int:DAZL
Interaction	BANP interactions	FAM217B UBAP2 RAD54L2 FAM222B LGALS4	2.37e-04	277	41	5	int:BANP
Interaction	WWOX interactions	WBP2 UBAP2 DDX17 PDCD6IP RC3H1 FAM222B YLPM1	2.44e-04	627	41	7	int:WWOX
Interaction	SNRPC interactions	DMRTB1 DDX17 FAM168A KLF1 SS18L1 YLPM1	2.46e-04	440	41	6	int:SNRPC
Interaction	TNRC6A interactions	DMRTB1 ARID1A PUM1 RC3H1 ALG13	2.49e-04	280	41	5	int:TNRC6A
Interaction	FLI1 interactions	ERG ARID1A KLF1	2.72e-04	62	41	3	int:FLI1
Interaction	CPEB4 interactions	UBAP2 PUM1 RC3H1 ALG13	2.80e-04	156	41	4	int:CPEB4
Interaction	CELF1 interactions	UBAP2 PUM1 RC3H1 YLPM1 ALG13	2.83e-04	288	41	5	int:CELF1
Interaction	PAIP2 interactions	PUM1 RC3H1 ALG13	2.85e-04	63	41	3	int:PAIP2
Interaction	YAP1 interactions	WBP2 FLNB UBAP2 DDX17 ARID1A FOXC1 EIF3L YLPM1 TBX2	2.89e-04	1095	41	9	int:YAP1
Interaction	HNRNPUL2 interactions	CDX2 ERG PUM1 RC3H1 FOXC1	2.97e-04	291	41	5	int:HNRNPUL2
Interaction	C10orf55 interactions	UBAP2 FAM168A FAM222B	3.13e-04	65	41	3	int:C10orf55
Interaction	BICRA interactions	ERG ARID1A SS18L1	3.42e-04	67	41	3	int:BICRA
Interaction	SF1 interactions	DMRTB1 DDX17 FAM168A RC3H1 ALG13	3.63e-04	304	41	5	int:SF1
Interaction	EWSR1 interactions	DMRTB1 DDX17 FAM168A ARID1A NIPBL CECR2 RC3H1 FOXC1	4.12e-04	906	41	8	int:EWSR1
Interaction	SSRP1 interactions	DDX17 ARID1A NFATC2 NIPBL FOXC1 EIF3L YLPM1	4.17e-04	685	41	7	int:SSRP1
Interaction	TLX1 interactions	ARID1A ZNF608 NIPBL FOXC1	4.33e-04	175	41	4	int:TLX1
Interaction	SOX2 interactions	DDX17 ERG ARID1A ZNF608 NIPBL FOXC1 MAEA EIF3L YLPM1 TBX2	4.40e-04	1422	41	10	int:SOX2
Interaction	FBXO43 interactions	FLNB PDCD6IP EIF3L	4.58e-04	74	41	3	int:FBXO43
Interaction	CNOT2 interactions	UBAP2 PUM1 RC3H1 TBX2	4.62e-04	178	41	4	int:CNOT2
Interaction	CELA2A interactions	PDCD6IP YLPM1	4.76e-04	16	41	2	int:CELA2A
Interaction	SECISBP2 interactions	DMRTB1 FAM168A PUM1	5.35e-04	78	41	3	int:SECISBP2
Interaction	NFIA interactions	ERG ARID1A ZNF608 FOXC1	5.67e-04	188	41	4	int:NFIA
Interaction	HNF1B interactions	ARID1A ZNF608 NIPBL FOXC1	5.90e-04	190	41	4	int:HNF1B
Interaction	CNFN interactions	VGLL3 FAM222B	6.05e-04	18	41	2	int:CNFN
Interaction	WBP2 interactions	WBP2 DDX17 FAM168A	6.19e-04	82	41	3	int:WBP2
Interaction	SOX7 interactions	ARID1A ZNF608 CECR2	6.19e-04	82	41	3	int:SOX7
Interaction	RAVER1 interactions	UBAP2 PUM1 RC3H1 ALG13	6.38e-04	194	41	4	int:RAVER1
Interaction	KLF5 interactions	CDX2 ARID1A ZNF608 NIPBL	6.51e-04	195	41	4	int:KLF5
Interaction	SMARCA2 interactions	CDX2 ERG ARID1A SS18L1 FOXC1	6.54e-04	346	41	5	int:SMARCA2
Interaction	R3HDM1 interactions	PUM1 RC3H1 ALG13	6.64e-04	84	41	3	int:R3HDM1
Interaction	SIRT7 interactions	FLNB PDCD6IP ARID1A PUM1 NIPBL EIF3L YLPM1	6.83e-04	744	41	7	int:SIRT7
Interaction	KRTAP3-1 interactions	VGLL3 FAM168A FAM222B	6.88e-04	85	41	3	int:KRTAP3-1
Interaction	HNRNPUL1 interactions	DMRTB1 DDX17 ERG RC3H1 FOXC1	6.97e-04	351	41	5	int:HNRNPUL1
Interaction	FMR1 interactions	UBAP2 PUM1 NIPBL CECR2 RC3H1 ALG13	7.01e-04	536	41	6	int:FMR1
Interaction	GATA2 interactions	ARID1A ZNF608 NIPBL FOXC1	7.02e-04	199	41	4	int:GATA2
Interaction	BRCA1 interactions	FLNB UBAP2 DDX17 ZMIZ1 RAD54L2 PDCD6IP ARID1A NIPBL EIF3L	7.56e-04	1249	41	9	int:BRCA1
Interaction	PRR12 interactions	ERG PUM1 ALG13	7.61e-04	88	41	3	int:PRR12
Interaction	SS18 interactions	ERG ARID1A SS18L1	7.61e-04	88	41	3	int:SS18
GeneFamily	HOXL subclass homeoboxes	GBX2 CDX2 HOXB13	4.94e-05	52	25	3	518
GeneFamily	T-boxes	EOMES TBX2	2.77e-04	18	25	2	766
CoexpressionAtlas	FacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#4	KLF1 FAM222B FOXC1 TBX2	1.88e-05	82	41	4	Facebase_RNAseq_e9.5_Mandibular Arch_500_K4
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_100	KLF1 CECR2 FOXC1 TBX2	3.94e-05	99	41	4	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_100
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DDX17 SPAG17 ZNF608 C4orf54 TBX2	4.87e-07	170	41	5	928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	ARID1A PUM1 ZNF608 RC3H1	1.63e-05	166	41	4	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAD54L2 ERG CECR2 LGALS4	1.75e-05	169	41	4	4e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCell	COVID-19_Convalescent\|World / Disease Group and Platelet Clusters	FLNB ERG NFATC2 FOXC1	2.00e-05	175	41	4	e9b1faa4c85537f30306619a2f3ada6c8ef0ac6c
ToppCell	facs-Brain_Myeloid-Cortex\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 ZMIZ1 HOXB13 LGALS4	2.44e-05	184	41	4	17f63dd671f9ff3dd2860d8de41b05c35c095950
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 DDX17 C4orf54 TBX2	2.76e-05	190	41	4	078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FLNB ERG ZNF608 NIPBL	3.37e-05	200	41	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	FLNB DDX17 ERG ZNF608	3.37e-05	200	41	4	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Ptgfr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	VGLL3 ERG DNAH9	2.16e-04	127	41	3	fb58f4b4d3722f4b9a2e4946c0244c5b70dd883b
ToppCell	COVID-19_Convalescent-PLT_3\|World / Disease Group and Platelet Clusters	FLNB NFATC2 FOXC1	2.71e-04	137	41	3	bb54bb81b450462ad521b57e1a07a80ce1678e67
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-VLMC-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VGLL3 FOXC1 TBX2	3.19e-04	145	41	3	7d90d95dc80b7d6230bc24ef6a524a8bb243a65e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-VLMC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VGLL3 FOXC1 TBX2	3.19e-04	145	41	3	18e958b7435fb4d7384f4ad5ab31d7a464a55eb9
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 DDX17 TBX2	3.19e-04	145	41	3	bfa196ac1db7acbfcbb2ba9f137036a95e16e091
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 C4orf54 TBX2	3.33e-04	147	41	3	b66ccc710b3c04f6fc7fed69f3c892fc110e98fc
ToppCell	facs-Skin-nan-24m-Epithelial-inner_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EOMES FLNB SPAG17	3.88e-04	155	41	3	fa2776d258e0420b2895de1008e292ad7725dac0
ToppCell	Ciliated_cells-A-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	CDX2 SPAG17 DNAH9	4.18e-04	159	41	3	0c65ae6140abd48c79b04758a6217709ddd15385
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	EOMES HOXB13 FOXC1	4.18e-04	159	41	3	a710551512aa0b7a281a81bea651a43c9f3b3539
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 DDX17 TBX2	4.26e-04	160	41	3	7064af50fc10e3ea03badf415306222b74db0f95
ToppCell	Ciliated_cells-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SPAG17 ASCL3 DNAH9	4.50e-04	163	41	3	43194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3\|GI_small-bowel / Manually curated celltypes from each tissue	FLNB IRX4 TBX2	4.74e-04	166	41	3	773673a5d0430640439845b264740bfbbdad0cb2
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	5.17e-04	171	41	3	f2b31c97bbcc5164fc279ed0362007878887ad5e
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	5.17e-04	171	41	3	3a2fefcb62e9d47ae6b3a946c45d3f2dd32c576c
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	5.17e-04	171	41	3	3ef44a5e3e8f81424f1e9aa302860b6688a549b8
ToppCell	facs-GAT-Fat-24m-Epithelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 IRX4 LGALS4	5.35e-04	173	41	3	815ba48a9222ea09ba8005e2d2f7c5addf118ad1
ToppCell	facs-GAT-Fat-24m-Epithelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 IRX4 LGALS4	5.35e-04	173	41	3	98e464d9e6d6b69421e9e4041b638b6825247f60
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB GBX2 ERG	5.35e-04	173	41	3	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	facs-GAT-Fat-24m-Epithelial-epithelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 IRX4 LGALS4	5.35e-04	173	41	3	3e6f0a08eddfd61871f7a85acccf6d539af6ebda
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	5.35e-04	173	41	3	021457c7bdb55de7351e43322d360e8fd7061658
ToppCell	343B-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	FLNB ZNF608 CECR2	5.53e-04	175	41	3	b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 ERG NFATC2	5.62e-04	176	41	3	9bc87cd5cda2372e1bce94c9dfd408eb1dfd8d0c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 ERG NFATC2	5.62e-04	176	41	3	3f8274a7ab67f9f8a8923193763a5543cfe4defa
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCP2 CDX2 LGALS4	5.81e-04	178	41	3	0f85602f652235b19d208e837896f32081052d3d
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 HOXB13 LGALS4	5.91e-04	179	41	3	bc93883c2094f2e5bfed79facd4994a23968d875
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 HOXB13 LGALS4	5.91e-04	179	41	3	0cef6d2eab2015cac0dd340532b24bfec9707330
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FLNB ERG FOXC1	5.91e-04	179	41	3	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	Striatum-Endothelial-MURAL\|Striatum / BrainAtlas - Mouse McCarroll V32	VGLL3 FOXC1 TBX2	5.91e-04	179	41	3	3d58babf44e47462c3d4129dd2e94a2339fd7ce0
ToppCell	facs-Brain_Myeloid-Cortex-24m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 HOXB13 LGALS4	5.91e-04	179	41	3	bb2410b3934fcc53396b96b48e0d9843df159b89
ToppCell	Striatum-Endothelial-MURAL-M1(Rgs5Acta2)\|Striatum / BrainAtlas - Mouse McCarroll V32	VGLL3 FOXC1 TBX2	5.91e-04	179	41	3	99167ac678cae5c35b1d4f4a81b32000437c00c2
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX2 HOXB13 LGALS4	5.91e-04	179	41	3	065241799cea30da62cb3b6f2f1970bd1b0f4e2b
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Mesenchymal-Mes-Pericyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VGLL3 FOXC1 TBX2	6.00e-04	180	41	3	e5c50d85e8df4e15f3e58f1f1d5aa25a375735de
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VGLL3 FOXC1 TBX2	6.00e-04	180	41	3	f5d757786a3be20756ad8b30edd53ff80b824974
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 C4orf54 LGALS4	6.10e-04	181	41	3	d74ee84146a72fd7cddf287f2e66d47d2c683bc4
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes-Pericyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VGLL3 FOXC1 TBX2	6.10e-04	181	41	3	634a4f4e5942473e60d08d0b0936407b04bc6b7c
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VGLL3 FOXC1 TBX2	6.10e-04	181	41	3	c2938cf1f5d4875be07a56a1f36c94f8eab37d99
ToppCell	droplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERG ZNF608 CECR2	6.10e-04	181	41	3	92d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Mesenchymal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VGLL3 FOXC1 TBX2	6.10e-04	181	41	3	c31a4386507877d59928398c8488856cd9c4b817
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Mesenchymal-Mes\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VGLL3 FOXC1 TBX2	6.10e-04	181	41	3	ddd0d0e5c629ac0644922ace46b9ec6d64d30f43
ToppCell	droplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERG ZNF608 CECR2	6.20e-04	182	41	3	81279877b920b5a1bc991a07d3031d6458700fe3
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ERG NFATC2 TBX2	6.20e-04	182	41	3	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF608 NIPBL CECR2	6.20e-04	182	41	3	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 SPAG17 C4orf54	6.30e-04	183	41	3	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	Striatum-Macroglia\|Striatum / BrainAtlas - Mouse McCarroll V32	CECR2 EIF3L ALG13	6.40e-04	184	41	3	9ed6a7c7171823b72561db9a6c1de47e82edc4c9
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF608 NIPBL CECR2	6.50e-04	185	41	3	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EOMES FLNB FOXC1	6.50e-04	185	41	3	3a046c948524e5d0e986cd645e318d6930d7e0ee
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	EOMES FLNB FOXC1	6.50e-04	185	41	3	71d1a771026d9fa3528d46ac3d11353e396f2d87
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EOMES FLNB FOXC1	6.50e-04	185	41	3	df5d2309d19ac8d5e429afa785d0a480e75a8f9e
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLNB ERG FOXC1	6.50e-04	185	41	3	a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF608 C4orf54 TBX2	6.50e-04	185	41	3	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EOMES FLNB FOXC1	6.50e-04	185	41	3	37b48218dd523049b57b13eb9cdb34e106cf91ea
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GBX2 ERG FOXC1	6.60e-04	186	41	3	055cc23c4db9aad2d6c62e62c8e58bfe5047c6b1
ToppCell	LV-10._Endothelium_II\|World / Chamber and Cluster_Paper	FLNB ERG FOXC1	6.71e-04	187	41	3	7876dcb4800c2e54874df3d933efb79307a64a97
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB ERG RC3H1	6.71e-04	187	41	3	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	6.71e-04	187	41	3	1909b65ba23d598e396f77eecae562bb59bf5d5d
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB ERG RC3H1	6.71e-04	187	41	3	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	6.81e-04	188	41	3	b3cae49f0665ace0016a6441cbf9ae40755b0ea3
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	6.92e-04	189	41	3	8478f433495dabe813146a1f6b00098db8ce775a
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Naive_B_cells\|bone_marrow / Manually curated celltypes from each tissue	ZNF608 CLEC17A CECR2	7.02e-04	190	41	3	3d45d5011305f13634013d9eeb98f235517dd54e
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EOMES FLNB FOXC1	7.13e-04	191	41	3	7a4fe96989f72159385270c712342ba3e1ca6fc3
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB ERG FOXC1	7.13e-04	191	41	3	fcdf3a747038e346a467eae8b7c293592658b53f
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB ERG FOXC1	7.13e-04	191	41	3	27f23c2254b610abac1a88d0fecff305addde9da
ToppCell	Control-Lymphoid_T/NK-NK_CD56bright\|Control / Disease group, lineage and cell class	EOMES FLNB FOXC1	7.13e-04	191	41	3	e842f29bc03ed6734b2a7b975e7830a498f2743c
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EOMES FLNB FOXC1	7.13e-04	191	41	3	f1935e8f8467a2bc30588b7f2cc3b94e9c83b268
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	EOMES FLNB FOXC1	7.13e-04	191	41	3	c023ca893ceae19b54967096f6e2588dc39fa268
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK_CD56bright-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EOMES FLNB FOXC1	7.13e-04	191	41	3	1161e465c50c2071764279e01cf08b1048cce0e3
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB GBX2 ERG	7.13e-04	191	41	3	3307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 C4orf54 TBX2	7.13e-04	191	41	3	0a0719a0a49ae0099d61e22585ac74c10c24b4a2
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	FLNB ERG FOXC1	7.24e-04	192	41	3	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 C4orf54 TBX2	7.24e-04	192	41	3	0bb06738e1c3ec0c044a7ee61f6cf1d4781fb53c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 C4orf54 TBX2	7.24e-04	192	41	3	d5ec4cdb15620a5abfc83577353501186c2bc86a
ToppCell	3'-GW_trimst-1-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	7.24e-04	192	41	3	9f7e0d610741288d0779bd7c02852c791431e4ea
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 C4orf54 TBX2	7.24e-04	192	41	3	9e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 C4orf54 TBX2	7.35e-04	193	41	3	e7012f7b53971972299db34fa51ff51a4e4987fe
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	7.35e-04	193	41	3	32eb026d4317c1499d51294d396dfd5f293f9deb
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB ERG ZNF608	7.35e-04	193	41	3	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	facs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ZMIZ1 FOXC1	7.35e-04	193	41	3	eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPAG17 ZNF608 DNAH9	7.35e-04	193	41	3	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB ERG ZNF608	7.35e-04	193	41	3	af5108260783e69a7d67896c5bf64f862525926d
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB ERG FOXC1	7.35e-04	193	41	3	58c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Vein\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB ERG FOXC1	7.35e-04	193	41	3	7261c1ce30c796b61c6ec58e64a051baa24732ff
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	7.35e-04	193	41	3	930df79b0600f43617052313294be33bcf5631f0
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 C4orf54 TBX2	7.35e-04	193	41	3	5da60321bcf761913eb30779b6d8b1e933c5e51e
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)\|390C / Donor, Lineage, Cell class and subclass (all cells)	FLNB ERG FOXC1	7.46e-04	194	41	3	f8a59bd4609d147d8a706bf606e9e8173c9992a3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VGLL3 C4orf54 TBX2	7.46e-04	194	41	3	be869e186386d03ebb670971dd24fa656b4b0edf
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FLNB ERG ZNF608	7.46e-04	194	41	3	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDX2 HOXB13 LGALS4	7.46e-04	194	41	3	07d8e38cbc2c7f0564c14f7c365f345f901b73b2
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	FAM217B UBAP2 ZNF608	7.46e-04	194	41	3	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FAM217B UBAP2 ZNF608	7.46e-04	194	41	3	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FLNB ERG FOXC1	7.46e-04	194	41	3	04b1acc2e879feafb43f75435281c5acd8d23be2
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	FLNB ERG FOXC1	7.46e-04	194	41	3	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	VGLL3 FOXC1 TBX2	7.46e-04	194	41	3	a7731378f44ca1a229311686caf5740c742d21ba
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	DDX17 ZMIZ1 ARID1A FOXC1 TBX2	9.50e-06	163	40	5	5594_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	ZMIZ1 ARID1A IRX4 FOXC1 TBX2	1.13e-05	169	40	5	5231_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA	ZMIZ1 ARID1A NIPBL FOXC1 TBX2	1.23e-05	172	40	5	1072_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	GBX2 DDX17 ARID1A PUM1 NIPBL	1.23e-05	172	40	5	7073_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	ZMIZ1 ARID1A IRX4 FOXC1 TBX2	1.30e-05	174	40	5	1659_DN
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A	GBX2 ZMIZ1 ARID1A PUM1 NIPBL	1.54e-05	180	40	5	4541_DN
Drug	Trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	ZMIZ1 ARID1A NIPBL FOXC1 TBX2	1.58e-05	181	40	5	6951_DN
Drug	SAHA; Down 200; 10uM; MCF7; HT_HG-U133A	DDX17 ZMIZ1 ARID1A FOXC1 TBX2	1.71e-05	184	40	5	6939_DN
Drug	Acetic Acid	EOMES GBX2 CDX2 NFATC2	3.43e-05	105	40	4	ctd:D019342
Drug	p-xylene	PDCD6IP ASCL3 SHISA5	6.77e-05	45	40	3	CID000007809
Disease	Malignant neoplasm of breast	EOMES FAM217B SCP2 FLNB ZMIZ1 ARID1A DNAH9 NIPBL HOXB13	1.33e-05	1074	41	9	C0006142
Disease	social deprivation, COVID-19	ERG CECR2	3.89e-04	21	41	2	EFO_0009696, MONDO_0100096
Disease	cancer (implicated_via_orthology)	DDX17 ARID1A NIPBL TBX2	5.17e-04	268	41	4	DOID:162 (implicated_via_orthology)
Disease	response to serotonin-norephinephrine reuptake inhibitor	NFATC2 MAEA	1.15e-03	36	41	2	EFO_0006325
Disease	hepatocyte growth factor-like protein measurement	RAD54L2 SHISA5	1.28e-03	38	41	2	EFO_0008154

Protein segments in the cluster

Peptide	Gene	Start	Entry
VYPAPNGARYPYGSM	EOMES	176	O95936
FVSPPQYPDYGGYHV	CDX2	31	Q99626
PHGAVYYPVMSDPYG	ALG13	1061	Q9NP73
YPSDLPYMGSYHAHP	ERG	411	P11308
YPGYMSPHAGYPAGG	RAD54L2	1416	Q9Y4B4
GMRYSYHPPPQPSYH	CECR2	1201	Q9BXF3
PPFEPAPYQQGMYYT	RC3H1	601	Q5TC82
MSYPQFGYPYSSAPQ	IRX4	1	P78413
MAYVPAPGYQPTYNP	LGALS4	1	P56470
VAMGPRQHYPYGGPY	ARID1A	1271	O14497
GLGSQPYYPQHPMVA	NFATC2	701	Q13469
NPPMMLPNGYVYGYN	MAEA	351	Q7L5Y9
NPKNMAYTGYPTAYP	FAM168A	16	Q92567
PYAYPSDYDMHTGDP	EIF3L	16	Q9Y262
PYMAFIHPATGGYNP	FLNB	631	O75369
PMPMGYNPYAYGQYN	PDCD6IP	816	Q8WUM4
YGQYNMPYPPVYHQS	PDCD6IP	826	Q8WUM4
PGQGHTKPEYYYPNF	FAM217B	131	Q9NTX9
NGMAAPLAYPNGHYF	FAM222B	436	Q8WU58
SPYAPQSPAGYMPYS	NIPBL	176	Q6KC79
QSPAGYMPYSHPSSY	NIPBL	181	Q6KC79
GMPGYPVLAPAAYYD	PUM1	546	Q14671
PGHFVYTGYPMFMPY	GBX2	36	P52951
SGYPAMYPAPQYQGH	KLF1	201	Q13351
PEYPGGSSMHPYCPF	DMRTB1	206	Q96MA1
YPGGMARAYGPYTPQ	FOXC1	56	Q12948
PMPYPNYRGCEYSYG	ASCL3	76	Q9NQ33
MIGYMGQTAYQYPPP	DDX17	706	Q92841
PLPGNMDYNGYHQYI	DNAH9	4151	Q9NYC9
EFAFYPGYPGTYQPM	HOXB13	126	Q92826
PGYPGTYQPMASYLD	HOXB13	131	Q92826
ALSPGAYGPTYMIYP	C4orf54	1666	D6RIA3
PPSYPGPSYQGYHTM	SHISA5	166	Q8N114
YGLSAHPVAPQMFGY	SCP2	151	P22307
PEPKITYPFHGYNMG	SPAG17	1011	Q6Q759
MHNLYSITGYPDPPG	CLEC17A	1	Q6ZS10
PMGQQYYPDGHGDYA	SS18L1	266	O75177
PYYTGMPSAFQYGPT	UBAP2	916	Q5T6F2
MPTFGGLFPYPYTYM	TBX2	566	Q13207
MYPNWGRYGGSSHYP	YLPM1	1	P49750
DPYYSPSYMHPGQVG	ZNF608	1001	Q9ULD9
VMYHPQPYGASQYLP	VGLL3	6	A8MV65
SGQYPPPTVNMGQYY	ZMIZ1	456	Q9ULJ6
YYNPGNPHNVYMPTS	WBP2	231	Q969T9