Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionferroxidase activity

CP HEPHL1

6.44e-056422GO:0004322
GeneOntologyMolecularFunctionoxidoreductase activity, acting on metal ions, oxygen as acceptor

CP HEPHL1

6.44e-056422GO:0016724
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH2 DYNC2H1

6.47e-0418422GO:0008569
GeneOntologyMolecularFunctionoxidoreductase activity, acting on metal ions

CP HEPHL1

6.47e-0418422GO:0016722
DomainMULTICOPPER_OXIDASE2

CP HEPHL1

1.48e-053422PS00080
DomainCu-oxidase_2

CP HEPHL1

2.95e-054422IPR011706
DomainCu-oxidase_2

CP HEPHL1

2.95e-054422PF07731
DomainCu_oxidase_CS

CP HEPHL1

4.92e-055422IPR033138
DomainCu-oxidase_3

CP HEPHL1

4.92e-055422IPR011707
DomainMULTICOPPER_OXIDASE1

CP HEPHL1

4.92e-055422PS00079
DomainCu-oxidase_3

CP HEPHL1

4.92e-055422PF07732
DomainCu_oxidase_Cu_BS

CP HEPHL1

7.36e-056422IPR002355
DomainDHC_N1

DNAH2 DYNC2H1

1.37e-048422PF08385
DomainDynein_heavy_dom-1

DNAH2 DYNC2H1

1.37e-048422IPR013594
Domain-

CP HEPHL1

4.42e-04144222.60.40.420
DomainDynein_heavy_chain_D4_dom

DNAH2 DYNC2H1

4.42e-0414422IPR024317
DomainDynein_HC_stalk

DNAH2 DYNC2H1

4.42e-0414422IPR024743
DomainDynein_heavy_dom-2

DNAH2 DYNC2H1

4.42e-0414422IPR013602
DomainDHC_N2

DNAH2 DYNC2H1

4.42e-0414422PF08393
DomainMT

DNAH2 DYNC2H1

4.42e-0414422PF12777
DomainAAA_8

DNAH2 DYNC2H1

4.42e-0414422PF12780
DomainATPase_dyneun-rel_AAA

DNAH2 DYNC2H1

4.42e-0414422IPR011704
DomainAAA_5

DNAH2 DYNC2H1

4.42e-0414422PF07728
DomainDHC_fam

DNAH2 DYNC2H1

5.09e-0415422IPR026983
DomainDynein_heavy_dom

DNAH2 DYNC2H1

5.09e-0415422IPR004273
DomainDynein_heavy

DNAH2 DYNC2H1

5.09e-0415422PF03028
DomainCupredoxin

CP HEPHL1

1.11e-0322422IPR008972
DomainTPR_REGION

DNAH2 TMTC3 CDC16

6.04e-03165423PS50293
DomainTPR

DNAH2 TMTC3 CDC16

6.04e-03165423PS50005
Pubmed

Exome sequencing in four families with neurodevelopmental disorders: genotype-phenotype correlation and identification of novel disease-causing variants in VPS13B and RELN.

RELN VPS13B

1.42e-06242238771357
Pubmed

The Placental Ferroxidase Zyklopen Is Not Essential for Iron Transport to the Fetus in Mice.

CP HEPHL1

1.42e-06242234114013
Pubmed

FGF15/FGF19 alleviates insulin resistance and upregulates placental IRS1/GLUT expression in pregnant mice fed a high-fat diet.

IRS1 FGF19

1.42e-06242234329971
Pubmed

Identification of zyklopen, a new member of the vertebrate multicopper ferroxidase family, and characterization in rodents and human cells.

CP HEPHL1

1.42e-06242220685892
Pubmed

[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].

CP HEPHL1

4.27e-06342224988611
Pubmed

Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.

PSMD1 CP SEC24D WIPI2 VCL

4.49e-0620242529540532
Pubmed

Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.

FKBP10 UBR5 TRRAP

4.69e-062742321320693
Pubmed

Eosinophil activation and novel mediators in the aspirin-induced nasal response in AERD.

A2M CP

8.53e-06442223786280
Pubmed

The ferroxidase ceruloplasmin influences Reelin processing, cofilin phosphorylation and neuronal organization in the developing brain.

CP RELN

1.42e-05542230077770
Pubmed

Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral phenotypes with females less affected.

RELN VPS13B

1.42e-05542237573958
Pubmed

Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes.

TXNL1 PSMD1 UBR5

1.69e-054142332723828
Pubmed

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.

UBR5 RRM2B

2.13e-05642232876667
Pubmed

The 20S proteasome as an assembly platform for the 19S regulatory complex.

TXNL1 PSMD1

3.97e-05842219781552
Pubmed

Helicobacter pylori regulates TIFA turnover in gastric epithelial cells.

TIFA PSMD1

3.97e-05842236965415
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

FKBP10 PSMD1 CP SEC24D ALAS1 IRS1 TMTC3 ALDH1L2 CTSZ

4.79e-05145142930550785
Pubmed

The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.

IRS1 UBR5

5.10e-05942222033112
Pubmed

Functional proteomics mapping of a human signaling pathway.

A2M PSMD1 SEC24D UBXN11 UBR5 VCL

7.32e-0559142615231748
Pubmed

IL-1 Transcriptional Responses to Lipopolysaccharides Are Regulated by a Complex of RNA Binding Proteins.

NSMF INTS11

7.78e-051142231953354
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

TXNL1 UBR5 WIPI2 VCL

1.19e-0420942436779422
Pubmed

Differential gene expression in migratory streams of cortical interneurons.

RELN NSMF

1.28e-041442222103416
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH2 DYNC2H1

1.28e-04144229373155
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

A2M TXNL1 FKBP10 PSMD1 TMTC3 UBR5 VCL

1.52e-0497442728675297
Pubmed

Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.

RELN FGF19

1.69e-041642221925158
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

POLR1B UBR5 TRRAP CDC16 RRM2B

1.83e-0444042534244565
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

TXNL1 GPRASP1 PSMD1 POLR1B UBR5 TRRAP DYNC2H1

1.84e-04100542719615732
Pubmed

Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.

UBR5 CDC16

1.91e-041742229033132
Pubmed

alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.

RELN FGF19

2.40e-041942216543460
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

DNAH2 A2M UBR5 TRRAP DYNC2H1 CDC16

2.75e-0475442635906200
Pubmed

Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.

NSUN4 HCFC2 RRM2B

3.23e-0411042326841866
Pubmed

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

TIFA SEC24D ALAS1 UBXN11 ZNF471 CDC16 CTSZ RRM2B

3.37e-04147742831515488
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TXNL1 FKBP10 ALAS1 TMTC3 UBR5 DYNC2H1 VPS13B VCL

3.53e-04148742833957083
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

HCFC2 UBR5 CDC16

4.07e-0411942323508102
Pubmed

Next-generation sequencing to generate interactome datasets.

TIFA SEC24D ALAS1 UBXN11 CDC16 CTSZ VCL

4.09e-04114742721516116
Pubmed

Patterning the dorsal telencephalon: a role for sonic hedgehog?

RELN FGF19

4.20e-042542217959802
Pubmed

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.

UBR5 TRRAP

4.20e-042542236708875
Pubmed

FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.

RELN FGF19

4.20e-042542218625063
Pubmed

Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells.

RELN FGF19

5.28e-042842227178193
Pubmed

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

SEC24D TRRAP

5.28e-042842229653964
Pubmed

A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium.

RELN FGF19

5.28e-042842220668538
Pubmed

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.

A2M CP INTS11

6.95e-0414342322516433
Pubmed

The transcription factor Otx2 regulates choroid plexus development and function.

RELN FGF19

7.34e-043342223364326
Pubmed

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.

PSMD1 UBR5

7.79e-043442232842143
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

FKBP10 NSUN4 SEC24D TMTC3 UBR5 TRRAP CTSZ

8.49e-04129742733545068
Pubmed

Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.

PSMD1 VCL

8.74e-043642216097034
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

DNAH2 FKBP10 PSMD1 TMTC3 UBR5 DYNC2H1

8.87e-0494242631073040
Pubmed

A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex.

RELN VCL

9.74e-043842232541003
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

UBR5 CDC16 RRM2B

1.09e-0316742325659891
Pubmed

MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.

PSMD1 UBR5

1.13e-034142234964862
Cytoband12q23.3

HCFC2 ALDH1L2

4.77e-043542212q23.3
CytobandEnsembl 112 genes in cytogenetic band chr8q22

UBR5 VPS13B RRM2B

4.98e-04168423chr8q22
CoexpressionZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM

A2M CP CTSZ VCL

3.68e-0667414M1686
CoexpressionZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM

A2M CP CTSZ VCL

4.64e-0671414MM1210
CoexpressionGSE24972_WT_VS_IRF8_KO_MARGINAL_ZONE_SPLEEN_BCELL_UP

PSMD1 TMTC3 ZNF471 WIPI2 VCL

1.47e-05200415M8097
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FKBP10 CTSZ TMPRSS11A

1.71e-0516442443630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FKBP10 CTSZ TMPRSS11A

1.71e-05164424108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FKBP10 CTSZ TMPRSS11A

1.71e-0516442446208f18325976c89f572f6627aea0582142b92d
ToppCellfacs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 CP RELN DYNC2H1

1.84e-05167424961e722442d786ab15d1e490941d2be265a9057a
ToppCellfacs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FKBP10 CP RELN DYNC2H1

1.84e-051674243760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M FKBP10 CP DYNC2H1

1.92e-05169424c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FKBP10 PHF19 CTSZ

2.46e-05180424ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M FKBP10 IRS1 TMPRSS11A

2.46e-0518042401f2e5d96016823482f89ba503d007d4bd88eeac
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH12 RELN UBXN11 ZNF319

2.74e-05185424bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIFA RELN IRS1 RRM2B

3.10e-051914244aa29337f4d2528577bb90dc4abfb6eab93e120f
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIFA RELN IRS1 RRM2B

3.10e-05191424318323a12029a7992f16382cb0c186f5b2e1ca47
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CP PLCXD3 VCL

3.23e-051934245b602b1702283184bd3943c2a6f2290b7c37e407
ToppCellCOVID-19_Severe-Plasmablast|COVID-19_Severe / disease group, cell group and cell class

TIFA SEC24D ALDH1L2 DIPK1A

3.23e-051934248074bcede261b85f9ae03ee372bd6d4b40384537
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CP PLCXD3 VCL

3.23e-05193424c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIFA RELN IRS1 RRM2B

3.30e-0519442411709704079f24a730476572dc2f01e9d2226e2c
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIFA RELN IRS1 RRM2B

3.30e-051944243a1f95639d5f239f001bd67d4213e8938e7f299d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M SEC24D PLCXD3 VCL

3.37e-05195424783bfa8110161cbd6def50ce849cae676c39c458
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M SEC24D PLCXD3 VCL

3.37e-05195424cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M SEC24D PLCXD3 VCL

3.43e-051964243a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M SEC24D PLCXD3 VCL

3.43e-05196424bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CP PLCXD3 VCL

3.43e-051964242b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Airway-Club|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DNAH2 CP HEPHL1 TMPRSS11A

3.57e-051984246712216c5a7fd86b68fd45b0ff7794975f19774e
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CP RELN UBXN11

2.97e-04138423611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IRS1 NSMF ALDH1L2

3.10e-04140423e442c46979d725ec82f525a001c46d971fcade4d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEC24D ALDH1L2 DIPK1A

4.02e-041534233724dd498b982be693ddff9cea7671863acf3ff8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEC24D ALDH1L2 DIPK1A

4.02e-04153423d810fc5aff28449ce79b4148558b260878a2c696
ToppCellmild_COVID-19_(asymptomatic)-MAIT|World / disease group, cell group and cell class (v2)

HCFC2 TMTC3 DYNC2H1

4.02e-041534232b4c69f6db17927d6506a645ac058133e60b0103
ToppCellmild_COVID-19_(asymptomatic)-MAIT|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

HCFC2 TMTC3 DYNC2H1

4.02e-0415342326852f3d8f80e102e24bcb90e24aac26fdc9a32c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FKBP10 PLCXD3

4.49e-041594232607b562903228274fbd96168ba826782fab0b53
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 RELN TMPRSS11A

4.49e-041594237619d0d49738dd08daf01b42664691a5323aa793
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FKBP10 PLCXD3

4.49e-04159423e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M RDH12 CTSZ

4.49e-04159423d9e535cf9a0a2302268f2897b010dcecc6426e41
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M RDH12 CTSZ

4.49e-0415942329999c87f5823f734e5cbf8ea8b729ec017db9b3
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 RELN TMPRSS11A

4.49e-041594234000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M RDH12 CTSZ

4.49e-041594234b840da854390f8285c219314cff4434d7ffcacc
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells-pDC|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RDH12 DIPK1A CTSZ

4.58e-04160423dee756a2dc9725520d439e7273c489c2284015d8
ToppCellnormal_Lung-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

A2M RDH12 GPRASP1

4.66e-04161423283012858e575c70d09950de53da041509f59bfa
ToppCellAdult-Epithelial-lung_goblet_cell-D175|Adult / Lineage, Cell type, age group and donor

CP ALDH1L2 TMPRSS11A

4.92e-041644236e6aedb61f8e195d52e028fdda750a29bb14e57e
ToppCellLPS-antiTNF-Stromal_mesenchymal-Fibroblasts-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPRASP1 UBXN11 RRM2B

5.01e-0416542315fd9d21dccfa80656a6fa3b72286a6a9252d403
ToppCelldroplet-Lung-LUNG-1m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH2 HEPHL1 GPR132

5.09e-04166423dd5944101ef58a9a29aa3eb5c17690119572b8f1
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH2 HEPHL1 GPR132

5.09e-041664238e5e8de51b4dacdadaa5a08279df30b5c7ed3628
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEC24D ALDH1L2 DIPK1A

5.18e-041674230130743084dbcb20e10f96715d30961122150cbf
ToppCell5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M RDH12 CTSZ

5.18e-041674232dc3de562a26077cb76855b725cf278a272d3276
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEC24D ALDH1L2 DIPK1A

5.18e-041674237bcae3797d3a0811e7f39885afdfd29ec517f11b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SEC24D ALDH1L2 DIPK1A

5.18e-04167423c6f0209a1ad797631fdfa3efab6db6b1d3e8e315
ToppCell356C-Fibroblasts-Fibroblast-H|356C / Donor, Lineage, Cell class and subclass (all cells)

A2M FKBP10 RELN

5.27e-04168423838ce47d4958ba12047882f97925eddd02f081c7
ToppCell356C-Fibroblasts-Fibroblast-H-|356C / Donor, Lineage, Cell class and subclass (all cells)

A2M FKBP10 RELN

5.27e-04168423b5d74500bdac0d680ce7eb7afa0b867b8d85e6a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M SEC24D PLCXD3

5.37e-04169423a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CP PLCXD3

5.46e-04170423fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CP PLCXD3

5.46e-0417042303044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TIFA PHF19 ALDH1L2

5.65e-04172423e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCellEndothelial-Endothelial-G|Endothelial / shred on cell class and cell subclass (v4)

TIFA CP RELN

5.65e-04172423644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M FKBP10 TMPRSS11A

5.74e-041734231f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIFA CP RELN

5.74e-0417342303b50b2376d353748a32bf14a9fc8341ea61dbca
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIFA CP RELN

5.74e-0417342312da47b90aecedaa31764ff7ddb853ee39123e9d
ToppCellPND28-Endothelial-Endothelial_lymphatic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIFA CP RELN

5.74e-041734232978c744d3c8dcaa2b9bb225abf846f82e8f9176
ToppCellPND28-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIFA CP RELN

5.74e-0417342323d4a315a0ad5c6fc77bcfc18b6c1ff55be99e8f
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

A2M CP DIPK1A

5.84e-04174423430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CP HEPHL1

5.84e-0417442395464817adef5ad2038bbf542f315756b7ad862e
ToppCellfacs-SCAT-Fat-24m-Lymphocytic-T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 PHF19 GPR132

5.84e-041744236ca9433d398aa3b48ecdc522dd545119e7c77dd4
ToppCellNS-moderate-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

A2M FKBP10 ALDH1L2

5.94e-04175423f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCellfacs-Marrow-B-cells-18m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC24D RELN ALDH1L2

6.04e-041764235f9ae5eb45603ed0422a3a993ecdbe2ce05d6e45
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GPR132 DIPK1A CTSZ

6.04e-04176423f3bbe8c1a8d132705eac360cf531261271d84588
ToppCellfacs-Marrow-B-cells-18m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC24D RELN ALDH1L2

6.14e-0417742335d42b07d9c31528bf59199e361bb8a3bfbe3b75
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M GPRASP1 ALDH1L2

6.24e-0417842309475e522dc1b8cf9ff1c25de5d1e3082b162948
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M GPRASP1 ALDH1L2

6.24e-0417842335de8f791b0e78a6caf52ff095f05e204a59e828
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC24D IRS1 TMTC3

6.24e-04178423fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellCOVID-19-Myeloid-MoAM4|Myeloid / Condition, Lineage and Cell class

A2M CP IRS1

6.24e-04178423fe0017e6a1f23dc45f644b9acacc7e8aa80d0116
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M GPRASP1 ALDH1L2

6.24e-04178423000d25f3f13cc76cf39c46c312c6fafc2ea4f368
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DNAH2 PLCXD3 RELN

6.34e-041794230b6731d9554f8bed1899c165a50e6b329ea19a6d
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M ZFHX2 TMPRSS11A

6.45e-04180423755050226eeb1991ee7f0d15e39d0458f3e4a791
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEC24D ALDH1L2 DIPK1A

6.55e-041814236cdee2f56bc633b387b4dbbd78c624edbd712c24
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEC24D ALDH1L2 DIPK1A

6.55e-041814235a4fe0eca7cbc9cbc8a2fdbe795a7c5f4052a659
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SEC24D ALDH1L2 DIPK1A

6.55e-04181423b75b8b025257bccfe661fd0f92ab284b2a9c12ee
ToppCellfacs-Lung-24m-Endothelial-lymphatic_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FKBP10 CP RELN

6.66e-041824230cde2775bdaaa2172499925bd59b0ac2d545eb27
ToppCellfacs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FKBP10 CP RELN

6.66e-041824232cc434e46985c66fc36de05344a67aa96d90abc9
ToppCelltumor_Lymph_Node_/_Brain-Endothelial_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

A2M PLCXD3 RELN

6.66e-04182423d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TIFA SEC24D ALDH1L2

6.66e-04182423a00abff41c12b71d5860c494b8c722d649fd5f36
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TIFA SEC24D ALDH1L2

6.66e-04182423626aabfd9ac662c1d189f7c4b660482914d9e669
ToppCellfacs-Lung-24m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FKBP10 CP RELN

6.66e-041824233e7457b2a70b45735fb75d6617b7f34cef28758e
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN UBXN11 ALDH1L2

6.76e-04183423876b4f128c2168fdae7488201ff44f19c06c8415
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN UBXN11 ALDH1L2

6.76e-04183423b190b650e61b1b20baf5e42d04acac82d3fd1400
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIFA RELN IRS1

6.76e-04183423bc24145855bf4d027a8058bf92bc796c10f241bb
ToppCellEndothelial-A-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

A2M FKBP10 PLCXD3

6.76e-041834232c3f2c25c38f0598b4787d2ec335efe00fdc9751
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M ZFHX2 CP

6.76e-04183423b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN UBXN11 ALDH1L2

6.76e-041834238330c39184ce076e1f95fd3725b68af551d89db0
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIFA RELN IRS1

6.76e-041834234c325ee6da070513097a11445ec95b0415ffd8a2
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4|TCGA-Uvea / Sample_Type by Project: Shred V9

SEC24D VPS13B RRM2B

6.87e-041844239c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POLR1B IRS1 RRM2B

6.87e-04184423a6dee97ee4ef9d89e11d17339e0dadaea1210ce5
ToppCellnormal_Lung-Fibroblasts-Myofibroblasts|normal_Lung / Location, Cell class and cell subclass

FKBP10 IRS1 ALDH1L2

6.87e-041844230b336489c10e8c3c957795dd845454f03404382b
ToppCell21-Trachea-Mesenchymal-Airway_Smooth_Muscle|Trachea / Age, Tissue, Lineage and Cell class

A2M FKBP10 IRS1

6.87e-0418442386a96cd88e50eacad1f0badfbbf6dc626f41725e
ToppCellLPS_only|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TIFA ALAS1 VPS13B

6.98e-04185423a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SEC24D ALDH1L2 DIPK1A

6.98e-041854233b77bc49cd3740acc025e162a36282ac09e12198
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CP ZNF319

6.98e-04185423e1fbec55b71f604189eb2431768fadbaa0453a83
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CP ZNF319

6.98e-041854239d933cd5ebc8368fd37aa83113d2dfa6938ff72d
ToppCelldroplet-Thymus-nan-24m-Myeloid-Plasma_cells_and_B_cells|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEC24D RELN ALDH1L2

6.98e-04185423e583f6601f9ed79b0b23d2f9426a4ba8b969230b
ToppCelldroplet-Bladder-nan-24m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH2 RELN PHF19

6.98e-0418542390caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M CP ZNF471

7.09e-04186423f07e0c0d9c80ac9d8d679950e7d0c812becb85a3
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

GPRASP1 NSMF VPS13B

7.09e-0418642377bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

GPRASP1 NSMF VPS13B

7.09e-0418642313bc41c60fd628af31899a5e8b480e06cc4781be
DiseaseRetinal Degeneration

RDH12 CP

3.52e-0421392C0035304
DiseaseHepatic Form of Wilson Disease

A2M CP

4.61e-0424392C1527352
DiseaseHepatolenticular Degeneration

A2M CP

4.61e-0424392C0019202
DiseaseDiabetes Mellitus

CP IRS1

8.23e-0432392C0011849
Diseasered blood cell density measurement

DNAH2 TMTC3 UBR5 VPS13B WIPI2 RRM2B

9.73e-04880396EFO_0007978

Protein segments in the cluster

PeptideGeneStartEntry
KMMAEIYANGPISCG

CTSZ

201

Q9UBR2
EIMVKMPYQCFINGQ

ALDH1L2

436

Q3SY69
LQMPYGCGEQNMVLF

A2M

966

P01023
FMYGNQPGLTMCKGD

CP

626

P00450
ILINNAGVMMCPYSK

RDH12

121

Q96NR8
PKMYVFGGMCGARLD

HCFC2

206

Q9Y5Z7
AGNEKNMVIMPGYCV

INTS11

341

Q5TA45
LLFYAQNCPKMMEVG

ALAS1

26

P13196
RYTNLMNPKICGLMA

OR2M2

131

Q96R28
LCMGADGKMQGLLQY

FGF19

101

O95750
MGCYILGNPNGEKLF

NSMF

461

Q6X4W1
SGGKLLPCTGDYMNM

IRS1

721

P35568
PGYMMQFKIVVGCEA

RELN

3116

P78509
PNLMANFGPMYFCKM

NSUN4

366

Q96CB9
CYLTLTQAMKMGLGG

DYNC2H1

1671

Q8NCM8
AQLMKGCHLPMLYIG

CDC16

361

Q13042
YIIPGMDQGLQGACM

FKBP10

321

Q96AY3
GYMYGNQPGLNMCKR

HEPHL1

626

Q6MZM0
PKLMGFCGDLYVMES

DIPK1A

216

Q5T7M9
LNDMGCIDPMYQFSL

DNAH2

3621

Q9P225
MCPMLLKNGYNGNAT

GPR132

1

Q9UNW8
SLFCEMFGGKPRNMV

GPRASP1

1076

Q5JY77
LNKMDLPYRCMVRFG

TIFA

106

Q96CG3
DMINMLKLGYFPGQC

PPWD1

166

Q96BP3
NDVPGMLAYSLKLCM

PSMD1

171

Q99460
MYNLDPQEGGECALM

WIPI2

356

Q9Y4P8
CKAYMCPFMQFIEGG

SEC24D

366

O94855
PVGLIGMNCILMKQY

RRM2B

271

Q7LG56
MLKDIYGNKMCPAIF

PLCXD3

161

Q63HM9
FQQLYGMKKGLFPMN

ZFHX2

2371

Q9C0A1
NVMMGPYRQDLLAKC

VCL

531

P18206
QCLNEPMMFGDRFYL

PHF19

226

Q5T6S3
DLCPMGFKQQYALMR

ZNF319

346

Q9P2F9
LPLKQFMYDDACMEG

ZNF471

96

Q9BX82
LMMGEPFFDCQIGFV

VPS13B

436

Q7Z7G8
PLDANGYFNLGMLAM

TMTC3

666

Q6ZXV5
MYQCQMGKQTMGFPL

POLR1B

686

Q9H9Y6
YLQLAGVMGKNECMQ

TRRAP

3086

Q9Y4A5
DIKPGMFCAGYMEGI

TMPRSS11A

346

Q6ZMR5
NGTIYPMAKDCMGGI

UBR5

816

O95071
KLYRNGIMMFDGPFQ

UBXN11

236

Q5T124
KGYMDLMPFINKAGC

TXNL1

121

O43396