Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription corepressor activity

TRERF1 HIPK3 NCOR1 NCOR2 HIPK2 TCF25 BCOR

1.04e-05229667GO:0003714
GeneOntologyMolecularFunctiontranscription coregulator activity

TRERF1 HIPK3 NCOR1 NCOR2 DYRK1A HIPK2 TCF25 BCOR MED12

9.22e-05562669GO:0003712
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

HIPK3 SCYL1 DYRK1A HIPK2 TTK

1.18e-04145665GO:0004713
GeneOntologyMolecularFunctionprotein serine kinase activity

HIPK3 TNNI3K MINK1 DYRK1A HIPK2 SIK3 TTK

1.92e-04363667GO:0106310
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

HIPK3 TNNI3K MINK1 DYRK1A HIPK2 SIK3 TTK

6.62e-04446667GO:0004674
GeneOntologyMolecularFunctionbeta-catenin binding

DLG5 PTPRK NUMB MED12

6.71e-04120664GO:0008013
GeneOntologyMolecularFunctionprotein kinase activity

HIPK3 TNNI3K MINK1 SCYL1 DYRK1A HIPK2 SIK3 TTK

7.86e-04600668GO:0004672
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine phosphatase activity

PTPRK PTPRM

1.42e-0317662GO:0005001
GeneOntologyMolecularFunctiontransmembrane receptor protein phosphatase activity

PTPRK PTPRM

1.42e-0317662GO:0019198
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

HIPK3 TNNI3K MINK1 SCYL1 DYRK1A HIPK2 SIK3 TTK

2.27e-03709668GO:0016773
GeneOntologyMolecularFunctiontau-protein kinase activity

DYRK1A SIK3

2.38e-0322662GO:0050321
GeneOntologyMolecularFunctionnuclear retinoid X receptor binding

NCOR1 NCOR2

2.60e-0323662GO:0046965
GeneOntologyMolecularFunctionnuclear receptor binding

TRERF1 NCOR1 NCOR2 MED12

3.42e-03187664GO:0016922
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

HIPK3 PARP11 TNNI3K MINK1 SCYL1 DYRK1A HIPK2 SIK3 TTK

3.58e-03938669GO:0016772
GeneOntologyMolecularFunctionkinase activity

HIPK3 TNNI3K MINK1 SCYL1 DYRK1A HIPK2 SIK3 TTK

3.58e-03764668GO:0016301
DomainN-CoR_GPS2_interact

NCOR1 NCOR2

1.27e-052672IPR031557
DomainGPS2_interact

NCOR1 NCOR2

1.27e-052672PF15784
DomainSANT_dom

TRERF1 NCOR1 NCOR2

1.08e-0426673IPR017884
DomainConA-like_dom

FAT1 PTPRK PTPRM PAPPA CLSTN2 RYR2

1.33e-04219676IPR013320
DomainSANT

TRERF1 NCOR1 NCOR2

1.36e-0428673PS51293
DomainMyb_DNA-binding

TRERF1 NCOR1 NCOR2

2.66e-0435673PF00249
DomainSer/Thr_kinase_AS

HIPK3 TNNI3K MINK1 DYRK1A HIPK2 SIK3 TTK

2.86e-04357677IPR008271
DomainPROTEIN_KINASE_ST

HIPK3 TNNI3K MINK1 DYRK1A HIPK2 SIK3 TTK

3.11e-04362677PS00108
DomainMYB_LIKE

TRERF1 NCOR1 NCOR2

3.40e-0438673PS50090
DomainProt_kinase_dom

HIPK3 TNNI3K MINK1 SCYL1 DYRK1A HIPK2 SIK3 TTK

3.51e-04489678IPR000719
DomainPROTEIN_KINASE_DOM

HIPK3 TNNI3K MINK1 SCYL1 DYRK1A HIPK2 SIK3 TTK

3.70e-04493678PS50011
DomainProtein_kinase_ATP_BS

HIPK3 TNNI3K MINK1 DYRK1A HIPK2 SIK3 TTK

4.09e-04379677IPR017441
DomainPkinase

HIPK3 MINK1 SCYL1 DYRK1A HIPK2 SIK3 TTK

4.22e-04381677PF00069
DomainKinase-like_dom

HIPK3 TNNI3K MINK1 SCYL1 DYRK1A HIPK2 SIK3 TTK

6.92e-04542678IPR011009
DomainSANT

TRERF1 NCOR1 NCOR2

7.67e-0450673SM00717
DomainSANT/Myb

TRERF1 NCOR1 NCOR2

8.60e-0452673IPR001005
DomainPROTEIN_KINASE_ATP

HIPK3 TNNI3K MINK1 DYRK1A HIPK2 SIK3 TTK

1.26e-03459677PS00107
DomainMAM_1

PTPRK PTPRM

1.47e-0316672PS00740
DomainMAM

PTPRK PTPRM

1.67e-0317672SM00137
DomainS_TKc

HIPK3 MINK1 DYRK1A HIPK2 SIK3 TTK

1.80e-03359676SM00220
DomainMAM

PTPRK PTPRM

1.87e-0318672PF00629
DomainMAM_dom

PTPRK PTPRM

1.87e-0318672IPR000998
DomainMAM_2

PTPRK PTPRM

1.87e-0318672PS50060
Domain-

FAT1 PAPPA CLSTN2

4.83e-03956732.60.120.200
DomainCARD

DLG5 APAF1

5.51e-0331672IPR001315
DomainCARD

DLG5 APAF1

6.23e-0333672PS50209
DomainPTPc

PTPRK PTPRM

7.38e-0336672SM00194
DomainTYR_PHOSPHATASE_PTP

PTPRK PTPRM

8.62e-0339672PS50055
DomainPTPase_domain

PTPRK PTPRM

9.50e-0341672IPR000242
DomainY_phosphatase

PTPRK PTPRM

9.50e-0341672PF00102
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

NCOR1 NCOR2 RBFOX1 HIPK2

6.08e-0563484M27862
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

HIVEP3 NCOR1 NCOR2 NUMB

1.70e-0482484MM15922
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

NCOR1 NCOR2 HIPK2

1.71e-0432483M27900
PathwayREACTOME_LOSS_OF_MECP2_BINDING_ABILITY_TO_THE_NCOR_SMRT_COMPLEX

NCOR1 NCOR2

2.36e-047482M27899
PathwayREACTOME_STIMULI_SENSING_CHANNELS

SLC9B1 TRPV4 ASIC4 RYR2

3.51e-0499484MM14910
PathwayREACTOME_NR1H2_NR1H3_REGULATE_GENE_EXPRESSION_TO_CONTROL_BILE_ACID_HOMEOSTASIS

NCOR1 NCOR2

4.03e-049482M29809
PathwayREACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS

NCOR2 PHC3 HIPK2

4.45e-0444483M27295
PathwayREACTOME_STIMULI_SENSING_CHANNELS

SLC9B1 TRPV4 ASIC4 RYR2

4.56e-04106484M27200
PathwayREACTOME_LOSS_OF_FUNCTION_OF_MECP2_IN_RETT_SYNDROME

NCOR1 NCOR2

8.65e-0413482M29766
Pubmed

Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.

NCOR1 NCOR2 BCOR

2.73e-08467315878880
Pubmed

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.

HIPK3 DYRK1A HIPK2

2.73e-08467334785661
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TRERF1 NCOR1 NCOR2 ATXN2 PRRC2C SVIL MINK1 DYRK1A LRP1 QSER1 SIK3 BCOR PREPL

3.30e-08963671328671696
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRERF1 TET2 NCOR1 NCOR2 PHC3 LRP1 BCOR RFX1 MED12

1.11e-0741867934709266
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

HIPK3 NCOR2 RBL2 MINK1 RBFOX1 SCYL1 DYRK1A HIPK2 NUMB SIK3 TTK LYST

1.53e-07910671236736316
Pubmed

A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene.

NCOR1 NCOR2 BCOR

3.80e-07867319491398
Pubmed

Interaction network of human early embryonic transcription factors.

TRERF1 TET2 NCOR1 NCOR2 TAF3 QSER1 BCOR MED12

3.86e-0735167838297188
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

DLG5 PRRC2C SCYL1 QSER1 BCOR TTK MED12

4.41e-0724267734011540
Pubmed

Human transcription factor protein interaction networks.

TRERF1 TET2 NCOR1 NCOR2 PHC3 FAT1 TAF3 ATXN2 PRRC2C SVIL HIPK2 QSER1 BCOR RFX1

4.66e-071429671435140242
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TET2 DLG5 PRRC2C SYDE2 SVIL MINK1 DYRK1A NUMB SIK3 TTK LYST

7.30e-07861671136931259
Pubmed

BCoR, a novel corepressor involved in BCL-6 repression.

NCOR1 NCOR2 BCOR

8.12e-071067310898795
Pubmed

Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.

NCOR1 NCOR2 PEBP1

8.12e-071067315001550
Pubmed

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.

NCOR1 NCOR2 BCOR

1.12e-061167323658227
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

NCOR1 NCOR2 DLG5 SVIL LRP1 BCOR

1.54e-0618467632908313
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TRERF1 NCOR1 NCOR2 PHC3 ATXN2 LITAF SCYL1 NUMB

1.76e-0643067835044719
Pubmed

Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.

TRERF1 NCOR1 NCOR2 C7orf25 NUMB

2.39e-0611067537219487
Pubmed

NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.

NCOR1 NCOR2

3.66e-06267229531310
Pubmed

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

NCOR1 NCOR2

3.66e-06267227733359
Pubmed

A novel protein with RNA-binding motifs interacts with ataxin-2.

ATXN2 RBFOX1

3.66e-06267210814712
Pubmed

Identification and expression of a mouse ortholog of A2BP1.

ATXN2 RBFOX1

3.66e-06267211471052
Pubmed

Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes.

NCOR1 NCOR2

3.66e-06267222944139
Pubmed

Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.

PTPRK PTPRM

3.66e-06267236436563
Pubmed

Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.

NCOR1 NCOR2

3.66e-06267221131350
Pubmed

Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.

NCOR1 NCOR2

3.66e-06267226166430
Pubmed

Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.

NCOR1 NCOR2

3.66e-06267219299558
Pubmed

Unique forms of human and mouse nuclear receptor corepressor SMRT.

NCOR1 NCOR2

3.66e-06267210077563
Pubmed

Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport.

NCOR1 NCOR2

3.66e-06267239106294
Pubmed

Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.

TET2 BCOR

3.66e-06267230228234
Pubmed

Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain.

PTPRK PTPRM

3.66e-0626727782276
Pubmed

Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.

NCOR1 NCOR2

3.66e-06267231208445
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TRERF1 TET2 NCOR1 NCOR2 ATXN2 PEBP1 PRRC2C QSER1 BCOR RFX1 MED12

7.85e-061103671134189442
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

HIPK3 TET2 NCOR1 BNC2 NCOR2 SVIL MINK1 APOBEC1

8.87e-0653667815840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

HIPK3 TET2 NCOR1 BNC2 NCOR2 SVIL MINK1 APOBEC1

9.12e-0653867810512203
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

NCOR1 TAF3 PRRC2C NUMB QSER1 BCOR RFX1 MED12

1.06e-0554967838280479
Pubmed

Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.

NCOR1 NCOR2

1.10e-05367216030140
Pubmed

Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor.

NCOR1 NCOR2

1.10e-05367219098224
Pubmed

The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.

NCOR1 NCOR2

1.10e-05367216373395
Pubmed

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

NCOR2 BCOR

1.10e-05367223911289
Pubmed

Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.

NCOR1 NCOR2

1.10e-05367231404087
Pubmed

Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.

NCOR1 NCOR2

1.10e-05367222337871
Pubmed

Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.

NCOR1 NCOR2

1.10e-05367223292142
Pubmed

Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.

NCOR1 NCOR2

1.10e-05367215016838
Pubmed

Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.

NCOR1 NCOR2

1.10e-05367224268577
Pubmed

Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis.

NCOR1 NCOR2

1.10e-05367234390859
Pubmed

Oligomerization of ETO is obligatory for corepressor interaction.

NCOR1 NCOR2

1.10e-05367211113190
Pubmed

RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.

NCOR1 NCOR2

1.10e-05367212011091
Pubmed

EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.

NCOR1 NCOR2

1.10e-05367221518914
Pubmed

Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis.

HIPK3 DLX2

1.10e-05367232977948
Pubmed

Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.

HIPK3 HIPK2

1.10e-05367229793420
Pubmed

Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.

NCOR1 NCOR2

1.10e-05367215802375
Pubmed

SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling.

NCOR1 NCOR2

1.10e-05367236238311
Pubmed

The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.

NCOR1 NCOR2

1.10e-05367210406466
Pubmed

Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.

NCOR1 NCOR2

1.10e-05367236316474
Pubmed

The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha.

NCOR1 NCOR2

1.10e-05367218052923
Pubmed

The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.

NCOR1 NCOR2

1.10e-05367211997503
Pubmed

Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor.

NCOR1 NCOR2

1.10e-05367218852122
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

NCOR2 ATXN2 MED12

1.18e-05236739225980
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

TRERF1 TET2 NCOR1 QSER1 BCOR MED12

1.33e-0526867633640491
Pubmed

BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.

NCOR1 NCOR2 BCOR

1.34e-052467333722704
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TRERF1 NCOR1 NCOR2 PHC3 TAF3 SVIL MINK1 BCOR RFX1

1.73e-0577467915302935
Pubmed

Functional proteomics mapping of a human signaling pathway.

HIPK3 NCOR1 NCOR2 LITAF LRP1 PAPPA RFX1 RYR2

1.79e-0559167815231748
Pubmed

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

TET2 NCOR2 QSER1

1.93e-052767323395962
Pubmed

MicroRNAs are mediators of androgen action in prostate and muscle.

NCOR1 NCOR2

2.19e-05467221048966
Pubmed

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

NCOR1 NCOR2

2.19e-0546729819405
Pubmed

Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.

NCOR1 NCOR2

2.19e-05467218362166
Pubmed

Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.

NCOR1 NCOR2

2.19e-05467218632669
Pubmed

Estrogenic induction of spermatogenesis in the hypogonadal mouse.

HIPK3 HIPK2

2.19e-05467210919273
Pubmed

Dichotomous engagement of HDAC3 activity governs inflammatory responses.

NCOR1 NCOR2

2.19e-05467232760002
Pubmed

A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones.

NCOR1 NCOR2

2.19e-05467219147680
Pubmed

A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain.

NCOR1 NCOR2

2.19e-05467232072640
Pubmed

NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.

NCOR1 NCOR2

2.19e-05467225421714
Pubmed

FBI-1 functions as a novel AR co-repressor in prostate cancer cells.

NCOR1 NCOR2

2.19e-05467220812024
Pubmed

Direct association between the CREB-binding protein (CBP) and nuclear receptor corepressor (N-CoR).

NCOR1 NCOR2

2.19e-05467217073437
Pubmed

The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.

NCOR1 NCOR2

2.19e-05467216024608
Pubmed

The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.

NCOR1 NCOR2

2.19e-05467211509652
Pubmed

Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development.

PTPRK PTPRM

2.19e-0546729510027
Pubmed

The retinoid X receptor binding to the thyroid hormone receptor: relationship with cofactor binding and transcriptional activity.

NCOR1 NCOR2

2.19e-05467219211732
Pubmed

Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.

NCOR1 NCOR2

2.19e-05467219595715
Pubmed

The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2.

DYRK1A HIPK2

2.19e-05467227307198
Pubmed

Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.

NCOR1 NCOR2

2.19e-05467216121196
Pubmed

A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.

NCOR1 NCOR2

2.19e-05467212840002
Pubmed

Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).

HIPK3 HIPK2

2.19e-05467225630557
Pubmed

The physical and genetic map surrounding the Lyst gene on mouse chromosome 13.

LYST RYR2

2.19e-0546729070932
Pubmed

Nuclear receptor coregulator SNP discovery and impact on breast cancer risk.

NCOR1 NCOR2

2.19e-05467220003447
Pubmed

A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.

TNNI3K RYR2

2.19e-05467233664309
Pubmed

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.

NCOR1 NCOR2

2.19e-05467220543827
Pubmed

GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression.

NCOR1 NCOR2

2.19e-05467226712002
Pubmed

Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.

NCOR1 NCOR2

2.19e-05467226712006
Pubmed

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.

NCOR1 NCOR2 DLX2

2.41e-052967317928865
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NCOR1 NCOR2 ATXN2 PEBP1 PRRC2C QSER1 BCOR

2.85e-0545767732344865
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

NCOR1 NCOR2 SIK3 BCOR RFX1 PREPL FER1L6 RYR2

3.09e-0563867831182584
Pubmed

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.

NCOR1 NCOR2

3.64e-0556727566114
Pubmed

ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus.

NCOR1 NCOR2

3.64e-05567212904255
Pubmed

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.

NCOR1 NCOR2

3.64e-05567215175761
Pubmed

Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor.

NCOR1 NCOR2

3.64e-05567214593076
Pubmed

Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.

NCOR1 NCOR2

3.64e-05567211865059
Pubmed

Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells.

NCOR1 NCOR2

3.64e-05567221088000
Pubmed

Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells.

NCOR1 NCOR2

3.64e-05567223703729
Pubmed

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

NCOR1 NCOR2

3.64e-05567215531890
Pubmed

Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter.

TET2 LYST

3.64e-05567229858571
InteractionFEV interactions

NCOR1 NCOR2 PHC3 TAF3 QSER1 BCOR RFX1

4.47e-06203667int:FEV
InteractionSP7 interactions

TRERF1 TET2 NCOR1 NCOR2 DLX2 QSER1 BCOR RFX1

6.57e-06304668int:SP7
InteractionNUP35 interactions

HIVEP3 NCOR1 NCOR2 ATXN2 PEBP1 PRRC2C DYRK1A QSER1 BCOR

9.51e-06424669int:NUP35
InteractionEGR2 interactions

TRERF1 TET2 NCOR1 NCOR2 QSER1 BCOR

2.04e-05171666int:EGR2
InteractionDCAF7 interactions

NCOR1 ATXN2 RBL2 SVIL DYRK1A HIPK2 NUMB BCOR

2.61e-05368668int:DCAF7
InteractionALG13 interactions

NCOR1 NCOR2 ATXN2 PRRC2C RBFOX1 BCOR

2.99e-05183666int:ALG13
InteractionPAX8 interactions

TET2 NCOR1 NCOR2 QSER1 BCOR

3.17e-05111665int:PAX8
InteractionTBR1 interactions

TET2 NCOR1 NCOR2 QSER1 BCOR

3.45e-05113665int:TBR1
InteractionFHL2 interactions

NCOR1 NCOR2 PHC3 PRRC2C DYRK1A HIPK2 QSER1 RFX1

4.40e-05396668int:FHL2
InteractionSKIL interactions

HIPK3 NCOR1 NCOR2 LRP1 PAPPA

4.42e-05119665int:SKIL
InteractionGCM1 interactions

TET2 NCOR1 NCOR2 BCOR

7.30e-0568664int:GCM1
InteractionERG interactions

TET2 NCOR1 NCOR2 HIPK2 QSER1 BCOR

8.96e-05223666int:ERG
InteractionTNNI3 interactions

TNNI3K PAPPA LYST

1.04e-0428663int:TNNI3
InteractionGUSBP5 interactions

NCOR1 NCOR2 ATXN2 BCOR

1.07e-0475664int:GUSBP5
InteractionSOX6 interactions

NCOR1 NCOR2 PRRC2C QSER1 BCOR

1.64e-04157665int:SOX6
InteractionQPRT interactions

NCOR1 NCOR2 PRRC2C BCOR

1.66e-0484664int:QPRT
InteractionCRX interactions

TRERF1 TET2 NCOR2 RBFOX1 QSER1 MED12

1.82e-04254666int:CRX
InteractionSOX5 interactions

NCOR1 NCOR2 PRRC2C QSER1 BCOR

1.90e-04162665int:SOX5
InteractionNUP43 interactions

NCOR1 NCOR2 PHC3 TAF3 PRRC2C CLSTN2 BCOR MED12 RYR2

1.92e-04625669int:NUP43
InteractionSAP30 interactions

TET2 NCOR1 NCOR2 PHC3 LYST

2.19e-04167665int:SAP30
InteractionKDM1A interactions

ZNF280A TRERF1 TET2 NCOR1 NCOR2 PHC3 DLG5 LRP1 BCOR RFX1 MED12

2.21e-049416611int:KDM1A
InteractionCNOT2 interactions

NCOR1 NCOR2 PRRC2C MINK1 DYRK1A

2.94e-04178665int:CNOT2
Cytoband12q24.1

ATXN2 TRPV4

2.18e-041567212q24.1
Cytoband4q24

TET2 SLC9B1

1.14e-03346724q24
Cytoband11p13

HIPK3 QSER1

3.07e-035667211p13
CytobandEnsembl 112 genes in cytogenetic band chr12q24

NCOR2 ATXN2 PEBP1 TRPV4

3.22e-03415674chr12q24
CytobandEnsembl 112 genes in cytogenetic band chr4q24

TET2 SLC9B1

3.40e-0359672chr4q24
CytobandEnsembl 112 genes in cytogenetic band chr11p13

HIPK3 QSER1

4.11e-0365672chr11p13
GeneFamilyAtaxins|Trinucleotide repeat containing

NCOR2 ATXN2 MED12

2.59e-0525423775
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

TRERF1 NCOR1 NCOR2

2.52e-0453423532
GeneFamilyCadherin related

FAT1 CLSTN2

7.01e-041742224
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRK PTPRM

1.08e-0321422813
CoexpressionGSE7568_CTRL_VS_3H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_DN

HIPK3 SYDE2 SVIL DYRK1A SIK3 BCOR RFX1

2.37e-07167677M361
CoexpressionRODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN

HIPK3 NCOR1 PHC3 ATXN2 PEBP1 RBL2 HIPK2 SIK3 RFX1 ANGPTL1 ITGB8

5.87e-068076711M16651
CoexpressionLAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2

BNC2 PTPRK PTPRM SVIL CLSTN2 ITGB8

5.98e-06176676M39223
CoexpressionGSE369_PRE_VS_POST_IL6_INJECTION_IFNG_KO_LIVER_DN

PRDM10 PTPRK C7orf25 DYRK1A APOBEC1 LYST

1.24e-05200676M5975
CoexpressionLAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES

HIVEP3 PTPRM SVIL DYRK1A HIPK2

2.70e-05137675M39241
CoexpressionNAKAYA_MONOCYTE_FLUMIST_AGE_18_50YO_7DY_UP

HIPK3 NCOR1 MINK1 APAF1 HIPK2 TMEM184C LYST PREPL

2.89e-05477678M40930
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

NCOR2 DLG5 FAT1 PEBP1 RBL2 SVIL RBFOX1 SHISA2 BCOR TTK ITGB8

4.65e-0510096711M157
CoexpressionRODRIGUES_THYROID_CARCINOMA_DN

BNC2 PTPRK HIPK2 ITGB8

4.82e-0578674M9814
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

NCOR2 FAT1 PTPRK PTPRM ATXN2 PRRC2C DYRK1A NUMB SIK3 TTK

6.02e-058566710M4500
CoexpressionGSE10147_IL3_VS_IL3_AND_HIVP17_STIM_PDC_UP

SYDE2 SIK3 BCOR RFX1 RYR2

6.75e-05166675M344
CoexpressionGSE7509_UNSTIM_VS_FCGRIIB_STIM_MONOCYTE_DN

TET2 NCOR1 PHC3 PRDM10 TCF25

6.75e-05166675M6826
CoexpressionLAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2

BNC2 SVIL RBFOX1 ITGB8

7.07e-0586674M39248
CoexpressionGSE14699_NAIVE_VS_ACT_CD8_TCELL_DN

HIPK2 NUMB QSER1 BCOR ANGPTL1

8.66e-05175675M2940
CoexpressionDE_YY1_TARGETS_DN

NCOR1 RBL2 HIPK2 TTK

9.59e-0593674M3278
CoexpressionGSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_DN

PHC3 TAF3 PTPRK LYST SLC25A37

1.58e-04199675M9236
CoexpressionMARTIN_INTERACT_WITH_HDAC

NCOR1 NCOR2 BCOR

1.59e-0441673M15154
CoexpressionGSE411_100MIN_VS_400MIN_IL6_STIM_MACROPHAGE_UP

NXPE4 SVIL MINK1 APOBEC1 BCOR

1.62e-04200675M5997
CoexpressionGSE28737_FOLLICULAR_VS_MARGINAL_ZONE_BCELL_DN

LITAF MINK1 APAF1 SIK3 AMTN

1.62e-04200675M9352
CoexpressionGSE8835_HEALTHY_VS_CLL_CD8_TCELL_UP

NCOR1 FRRS1 LRP1 APOBEC1 QSER1

1.62e-04200675M6262
CoexpressionGSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP

DLG5 PTPRK CD22 RNF44 LYST

1.62e-04200675M4440
CoexpressionTURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN

DLG5 SHISA2 BCOR ITGB8 SLC25A37

1.86e-04206675M14134
CoexpressionLAKE_ADULT_KIDNEY_C2_PODOCYTES

TET2 FAT1 RBFOX1 SIK3 ITGB8

2.12e-04212675M39221
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_UP

HIPK3 NCOR1 CD22 APAF1 SIK3

2.47e-04219675M41199
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TRERF1 PRDM10 CARF ITGB8 IQUB RYR2

2.05e-07168676c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TRERF1 PRDM10 CARF ITGB8 IQUB RYR2

2.05e-0716867683b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRERF1 BNC2 RBFOX1 LRP1 PAPPA RYR2

3.39e-071836767eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 FAT1 NUMB PAPPA CLSTN2 ITGB8

3.85e-071876769d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellRA-14._Fibroblast_III|RA / Chamber and Cluster_Paper

BNC2 NCOR2 FAT1 LITAF PAPPA SIK3

4.09e-0718967646e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 RBFOX1 LRP1 PAPPA ANGPTL1 RYR2

4.09e-0718967645e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HIVEP3 BNC2 LRP1 PAPPA ITGB8 RYR2

4.22e-0719067645df8fee00f8949937863159d7aa042e72748d9b
ToppCellCTRL-Myeloid-Alveolar_Macrophage|Myeloid / Disease state, Lineage and Cell class

PTPRM PEBP1 SVIL LRP1 HIPK2 ITGB8

4.63e-0719367680871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

PRDM10 CARF ITGB8 IQUB RYR2

5.48e-061686751bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

PRDM10 CARF ITGB8 IQUB RYR2

5.48e-0616867569f534de0f9a293047bea03cb1b78551087a8df5
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRERF1 BNC2 RBFOX1 LRP1 PAPPA

8.75e-061856753b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 FAT1 RBFOX1 CLSTN2 ITGB8

9.45e-06188675b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 FAT1 RBFOX1 CLSTN2 ITGB8

9.45e-06188675874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 FAT1 PTPRK CLSTN2 ITGB8

9.70e-061896753b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellRA-14._Fibroblast_III|World / Chamber and Cluster_Paper

BNC2 FAT1 LITAF PAPPA SIK3

9.70e-06189675b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

BNC2 FAT1 PAPPA CLSTN2 ITGB8

9.70e-061896750be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

FAT1 SVIL RBFOX1 SIK3 RYR2

9.95e-0619067593c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellCOPD-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

PTPRM PEBP1 SVIL LRP1 ITGB8

9.95e-061906759fc763d65470ba8858b973689c4d4358faab7dd3
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 RBFOX1 LRP1 PAPPA RYR2

1.02e-0519167514057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 FAT1 PTPRK CLSTN2 ITGB8

1.02e-051916751cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 PTPRK PTPRM SVIL SIK3

1.05e-05192675e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellCOPD-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

HIVEP3 BNC2 LITAF HIPK2 LYST

1.07e-051936750020249fa71afb500af73700543bb6f349be6b10
ToppCellLV-14._Fibroblast_III|LV / Chamber and Cluster_Paper

BNC2 NCOR2 FAT1 TMEM184C PAPPA

1.10e-05194675927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCellCTRL-Myeloid-Alveolar_Macrophage|CTRL / Disease state, Lineage and Cell class

PTPRM PEBP1 SVIL LRP1 HIPK2

1.10e-05194675be69b20afa915978c4cf2feb0bb21ab7c1f301a5
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

HIVEP3 PTPRK PTPRM DYRK1A SIK3

1.16e-05196675ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellBronchial-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRERF1 BNC2 TNNI3K CD22 ASIC4

1.19e-05197675bed8a9b73af5caee51b1232b31c24a59353658df
ToppCellBronchial-NucSeq-Immune_Myeloid-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TRERF1 BNC2 TNNI3K CD22 ASIC4

1.19e-05197675b7d5073d44aa1e2cb83ea8d8104c5ed662665755
ToppCellsevere-HLA-DR+_CD83+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 LRP1 NUMB LYST SLC25A37

1.21e-05198675a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

HIPK3 BNC2 LITAF SVIL SIK3

1.21e-05198675b8bd1ba268480f54451648e01631b615a3401144
ToppCellsevere-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TET2 LRP1 NUMB LYST SLC25A37

1.21e-05198675d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCellcritical|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CD22 LITAF NUMB LYST SLC25A37

1.24e-0519967516c55cb8a0e740342009965f0eddfb0ed2858fab
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FAT1 PRDM10 PRRC2C ITGB8 UTP14C

1.24e-05199675174f6013af6eafa577f84205a62927f2b367fda3
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

HIVEP3 LRP1 PAPPA ITGB8 RYR2

1.24e-051996758b86c69aaf60feff53aa782559cfece7342a23de
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Mesoderm|6m / Sample Type, Dataset, Time_group, and Cell type.

HIPK3 SVIL RBFOX1 SHISA2 CLSTN2

1.27e-052006750f6851baf0cf2a8b0c95a7a585c4407c330c5f6c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FAT1 SVIL DLX2 ASIC4

3.68e-0512467436dfc702a570e1a1a6dde09f38badf9023ea7287
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MS4A8 CLSTN2 TTK FER1L6

4.99e-0513467464979e1a056b7406e1be39c5ebe2f8d731ac3c17
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|GI_small-bowel / Manually curated celltypes from each tissue

DLG5 LITAF DLX2 LYST

5.13e-0513567411a672ab6cba7026b8d81d8b216443cb88c0d47a
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FAT1 SVIL DLX2 ASIC4

5.75e-051396749e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MS4A8 CLSTN2 TTK FER1L6

6.25e-051426745690eee2ce1ecd02e34eac4193578bd13c4228b9
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FAT1 SVIL DLX2 ASIC4

8.34e-051536749c6fce56300ba5053efda59a438d63a808c497c0
ToppCellfacs-MAT-Fat-24m-Myeloid-macrophage|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRERF1 FRRS1 MS4A8 APOBEC1

8.77e-05155674d0c1608f8f6b6f4174e51d610501c707cba5e015
ToppCellfacs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM NXPE4 MINK1 SLC25A37

8.99e-051566745caefdc6cc86f2ac52abe8c8da821db14f476915
ToppCellfacs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM NXPE4 MINK1 SLC25A37

8.99e-05156674758f57dc10fc5cad200bf5b310c10ec9b1405f23
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pappa_(ventral_GP_(vGP))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TNNI3K PAPPA FER1L6

9.67e-055967322f5abf0b7fca1c9b7ce8d1f5e09eebad8937f11
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pappa_(ventral_GP_(vGP))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TNNI3K PAPPA FER1L6

9.67e-0559673804f6ec763209b2513e7688925136033b41a7b61
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Pappa_(ventral_GP_(vGP))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TNNI3K PAPPA FER1L6

9.67e-0559673025a2df1825fbfa7f37764371dae9296cb9908b6
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PRRC2C SYDE2 DLX2 ASIC4

9.68e-051596747f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MS4A8 TRPV4 SLC25A37

9.92e-0516067456e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MS4A8 TRPV4 SLC25A37

9.92e-05160674bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MS4A8 TRPV4 SLC25A37

1.02e-0416167460f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCellfacs-Marrow-T_cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM NXPE4 LRP1 MS4A8

1.07e-0416367430cd95d4f37bd54c1fde54960cb005db58bdd30c
ToppCellfacs-Marrow-T_cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRM NXPE4 LRP1 MS4A8

1.07e-04163674ab934cb986495adfc8dbe5a276577f2a8fb6ee03
ToppCelldroplet-Kidney-nan-24m-Myeloid-CD45____macrophage|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 LRP1 MS4A8 APOBEC1

1.09e-04164674d57faa4fce1f1e9a92aaf5cb920af99323252e4b
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARF NUMB LYST SLC25A37

1.09e-04164674f9a2cc12179d5621c9174ec01d7418a71edd28d1
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRERF1 BNC2 CD22 ASIC4

1.12e-0416567437615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRERF1 BNC2 CD22 ASIC4

1.12e-04165674640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TRERF1 BNC2 CD22 ASIC4

1.12e-04165674f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

BNC2 FAT1 RBFOX1 ITGB8

1.20e-04168674a086c306be430adf0632ba53e98cd8014d2de330
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

PTPRM PRRC2C DLX2 ASIC4

1.22e-04169674c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCelldroplet-Marrow-BM-1m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 LRP1 MS4A8 APOBEC1

1.22e-041696748066b4c02c97d00034802cff2b39799ef44cc904
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM10 NUMB PAPPA SHISA2

1.25e-0417067450c6c571591aa4b218caefe5778c570c809f567e
ToppCellCOVID-19-lung-MAST|lung / Disease (COVID-19 only), tissue and cell type

TRERF1 BNC2 CD22 ASIC4

1.25e-04170674e90f18e5462381b38e918442b38b1c8105291908
ToppCelldroplet-Spleen-nan-21m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 LRP1 MS4A8 AMTN

1.25e-0417067403cb4e508356f85372a588c8d1c6babf2a012683
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM10 NUMB PAPPA SHISA2

1.25e-041706748fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LITAF SVIL DLX2 ASIC4

1.25e-0417067414aa86a4f526ed6986afcb28c49225522055550c
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRDM10 NUMB PAPPA SHISA2

1.25e-041706743232db50b1a40f861e981a1b9c9073b81af9f832
ToppCelldroplet-Spleen-nan-21m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 LRP1 MS4A8 AMTN

1.28e-041716749498c35b2a2c3a339dc8c5d49c8ec20d8ad52753
ToppCelldroplet-Spleen-nan-21m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 LRP1 MS4A8 AMTN

1.28e-04171674db544252f98e073e5bb4bec4a110cd58e6434435
ToppCelldroplet-Marrow-nan-3m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 MS4A8 APOBEC1 LYST

1.28e-04171674992df143d76f9e7fb1997a8996f61e941f0f9d4f
ToppCell10x5'-GI_small-bowel-Lymphocytic_NK|GI_small-bowel / Manually curated celltypes from each tissue

BNC2 LITAF SVIL LYST

1.37e-0417467409b216f07cffd3ea2149ea95ffb5cd7219b3a98c
ToppCelldroplet-Marrow-BM-30m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NXPE4 LRP1 MS4A8 APOBEC1

1.37e-04174674118ba2729ecc6aa1bb8548f3cf537b3f9e902ef0
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAT1 RBFOX1 SHISA2 ITGB8

1.40e-04175674a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LITAF SVIL DLX2 ASIC4

1.43e-0417667405ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCellCOVID-19-lung-MAST|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRERF1 BNC2 CD22 ASIC4

1.43e-04176674473c45a381ca109207d66ed1635668b391ea0e1f
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCOR2 PRDM10 C7orf25 MS4A8

1.43e-0417667490f8bb11f339f67f08692a0c33dd420f5cda2861
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

BNC2 FAT1 RBFOX1 ITGB8

1.49e-04178674544379f5a6145429762258d426b876bb36c112f5
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HIVEP3 BNC2 LRP1 RYR2

1.56e-0418067408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

BNC2 FAT1 PAPPA ITGB8

1.56e-04180674358923e4228035a3e90e2957392089219e90dcd7
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

BNC2 FAT1 PAPPA ITGB8

1.56e-04180674864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TRERF1 PAPPA TRPV4 IQUB

1.56e-04180674023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DMGDH HIPK2 CLSTN2 ITGB8

1.59e-041816749d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BNC2 CLSTN2 ANGPTL1 RYR2

1.59e-04181674b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

RBFOX1 TRPV4 BCOR RYR2

1.59e-04181674c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 FAT1 RBFOX1 ITGB8

1.59e-041816745f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 FAT1 RBFOX1 ITGB8

1.59e-04181674c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DMGDH HIPK2 CLSTN2 ITGB8

1.63e-04182674eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT1 HIPK2 PAPPA RYR2

1.63e-04182674ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD22 PRRC2C TCF25 LYST

1.63e-04182674eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCellHippocampus-Neuronal-Inhibitory|Hippocampus / BrainAtlas - Mouse McCarroll V32

PTPRM PRRC2C DLX2 ASIC4

1.63e-04182674b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TRERF1 BNC2 RBFOX1 PAPPA

1.66e-0418367412daaea821e49bc94a01e2496331e92a80d27339
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

PTPRM SVIL RBFOX1 RYR2

1.70e-04184674ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

BNC2 SVIL PAPPA RYR2

1.73e-041856747dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

PTPRK PTPRM ATXN2 LRP1

1.73e-041856741d874608aa2062024323512f68889219471b2f00
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

BNC2 HIPK2 ANGPTL1 RYR2

1.77e-041866747def03dd856b765bd3f493288641981c4f7fd26e
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PRRC2C LRP1 TCF25 RYR2

1.77e-0418667423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 PTPRK PAPPA ITGB8

1.77e-04186674b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

BNC2 FAT1 PAPPA ITGB8

1.81e-04187674d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FAT1 HIPK2 PAPPA CLSTN2

1.81e-04187674c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCellLV-14._Fibroblast_III|World / Chamber and Cluster_Paper

BNC2 NCOR2 FAT1 TMEM184C

1.88e-041896743922135d1f6fc768d71ba3b465585fead6ea68a8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BNC2 PAPPA CLSTN2 ITGB8

1.88e-04189674204ab61ae606b2d9be0cb6bf6a83a011740693a8
DrugDemeclocycline hydrochloride [64-73-3]; Up 200; 8uM; MCF7; HT_HG-U133A

HIVEP3 CD22 C7orf25 HIPK2 CLSTN2 SLC25A37 RYR2

1.65e-061946773404_UP
Drugpioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A

HIPK3 HIVEP3 ATXN2 CARF RBFOX1 DLX2 LYST

1.89e-061986777506_DN
DrugCV-1

TRERF1 HIPK3 NCOR1 NCOR2 PHC3 SVIL MED12

3.07e-06213677CID000130105
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

DLG5 PRDM10 C7orf25 RBL2 DYRK1A HIPK2

1.16e-051726767073_DN
DrugRetinoic acid [302-79-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

PRDM10 CD22 MINK1 RBFOX1 DLX2 RYR2

1.98e-051896763165_UP
DrugFlunisolide [3385-03-3]; Up 200; 9.2uM; PC3; HT_HG-U133A

PARP11 CD22 MINK1 APAF1 LRP1 DLX2

2.16e-051926764303_UP
DrugICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A

HIPK3 PHC3 CARF RBFOX1 HIPK2 RYR2

2.23e-051936767490_UP
DrugPramoxine hydrochloride [637-58-1]; Up 200; 12.2uM; PC3; HT_HG-U133A

NCOR2 PRDM10 CD22 APAF1 DYRK1A APOBEC1

2.23e-051936763811_UP
DrugPHA-00851261E [724719-49-7]; Up 200; 10uM; MCF7; HT_HG-U133A

HIVEP3 PARP11 NCOR2 RBL2 DYRK1A DLX2

2.30e-051946763854_UP
DrugClozapine [5786-21-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A

HIVEP3 PARP11 NCOR2 RBL2 APOBEC1 RYR2

2.36e-051956765265_UP
DrugBromocryptine mesylate [22260-51-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A

PARP11 CARF HIPK2 TCF25 QSER1 ITGB8

2.36e-051956765665_UP
DrugProadifen hydrochloride [62-68-0]; Up 200; 10.2uM; HL60; HT_HG-U133A

NCOR2 MINK1 RBFOX1 DLX2 QSER1 ASIC4

2.43e-051966762707_UP
DrugIoversol [87771-40-2]; Up 200; 5uM; MCF7; HT_HG-U133A

HIPK3 HIVEP3 CD22 APAF1 TRPV4 APOBEC1

2.50e-051976763365_UP
DrugPropoxycaine hydrochloride [550-83-4]; Up 200; 12uM; MCF7; HT_HG-U133A

ZNF280A PTPRM CD22 RBFOX1 TCF25 PAPPA

2.50e-051976766803_UP
Drugaspirin, USP; Up 200; 100uM; HL60; HT_HG-U133A

HIPK3 DLG5 PRDM10 PTPRK APAF1 RFX1

2.50e-051976762664_UP
DrugTheophylline monohydrate [5967-84-0]; Up 200; 20.2uM; MCF7; HT_HG-U133A

NCOR2 PHC3 CD22 MINK1 APAF1 TCF25

2.57e-051986764812_UP
DrugFosfosal [6064-83-1]; Up 200; 18.4uM; HL60; HT_HG-U133A

HIPK3 PTPRM NXPE4 APAF1 TRPV4 APOBEC1

2.72e-052006762997_UP
Drughalofenate

NCOR1 NCOR2

5.10e-054672CID000033584
DrugAsbestos, Crocidolite

TRERF1 HIPK3 HIVEP3 NCOR1 PHC3 SYDE2 CARF PAPPA DLX2 SIK3 LYST MED12 SLC25A37

5.69e-0512416713ctd:D017638
DrugFendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; MCF7; HT_HG-U133A

PTPRM RBFOX1 LRP1 PAPPA DLX2

2.05e-041836753190_UP
DrugDicumarol [66-76-2]; Down 200; 11.8uM; PC3; HT_HG-U133A

HIPK3 PHC3 RBL2 HIPK2 LYST

2.27e-041876754323_DN
Drugvitamin B

DMGDH NCOR2 APAF1 HIPK2 NUMB TRPV4

2.31e-04295676CID000000936
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A

HIPK3 HIVEP3 PTPRM APAF1 PAPPA

2.32e-041886755596_UP
Drug2-oxy

DYRK1A HIPK2

2.36e-048672CID005149739
DrugDicyclomine hydrochloride [67-92-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A

HIVEP3 C7orf25 RBFOX1 DYRK1A DLX2

2.44e-041906751483_UP
DrugPiperacetazine [3819-00-9]; Up 200; 9.8uM; MCF7; HT_HG-U133A

HIPK3 PTPRM RBFOX1 ASIC4 LYST

2.50e-041916753574_UP
DrugLY 294002; Up 200; 10uM; MCF7; HT_HG-U133A

RBL2 MINK1 NUMB QSER1 RYR2

2.62e-041936751652_UP
Drug(-)-Quinpirole hydrochloride [85760-74-3]; Down 200; 15.6uM; MCF7; HT_HG-U133A

HIVEP3 HIPK2 CLSTN2 QSER1 RYR2

2.68e-041946753539_DN
DrugMycophenolic acid [24280-93-1]; Down 200; 12.4uM; PC3; HT_HG-U133A

PHC3 DLG5 SVIL HIPK2 QSER1

2.75e-041956754019_DN
DrugFlumethasone [2135-17-3]; Up 200; 9.8uM; MCF7; HT_HG-U133A

HIPK3 NCOR2 CD22 RBFOX1 RYR2

2.75e-041956754734_UP
DrugClenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A

PTPRM RBFOX1 APAF1 APOBEC1 ASIC4

2.75e-041956755631_UP
DrugHarmaline hydrochloride dihydrate [6027-98-1]; Up 200; 14uM; MCF7; HT_HG-U133A

ZNF280A CD22 HIPK2 MED12 RYR2

2.75e-041956752805_UP
DrugEthotoin [86-35-1]; Up 200; 19.6uM; MCF7; HT_HG-U133A

DYRK1A LRP1 TRPV4 APOBEC1 LYST

2.75e-041956756052_UP
DrugSulfamerazine [127-79-7]; Down 200; 15.2uM; PC3; HT_HG-U133A

HIPK3 NCOR2 CD22 DLX2 RYR2

2.75e-041956753718_DN
DrugBoldine [476-70-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A

HIVEP3 PHC3 DLG5 PTPRM CLSTN2

2.81e-041966754122_DN
DrugCimetidine [51481-61-9]; Down 200; 15.8uM; PC3; HT_HG-U133A

DLG5 CD22 LITAF RBL2 LRP1

2.81e-041966754063_DN
DrugNitrendipine [39562-70-4]; Up 200; 11uM; MCF7; HT_HG-U133A

HIPK3 APAF1 DYRK1A CLSTN2 QSER1

2.81e-041966756464_UP
Drug(R) -Naproxen sodium salt [26159-34-2]; Up 200; 15.8uM; HL60; HT_HG-U133A

HIPK3 PHC3 CARF RBFOX1 APAF1

2.81e-041966752533_UP
Drugchlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT_HG-U133A

DYRK1A TRPV4 DLX2 ITGB8 RYR2

2.81e-041966755577_UP
DrugPF-00539745-00 [351321-33-0]; Down 200; 10uM; MCF7; HT_HG-U133A

NCOR2 PHC3 CD22 MINK1 ASIC4

2.81e-041966755974_DN
DrugTridihexethyl chloride; Up 200; 11.4uM; MCF7; HT_HG-U133A

MINK1 PAPPA CLSTN2 LYST SLC25A37

2.81e-041966755486_UP
DrugPF-00539745-00 [351321-33-0]; Up 200; 10uM; PC3; HT_HG-U133A

NCOR2 APAF1 LRP1 HIPK2 TMEM184C

2.81e-041966755979_UP
DrugBezafibrate [41859-67-0]; Up 200; 11uM; MCF7; HT_HG-U133A

MINK1 APAF1 PAPPA DLX2 QSER1

2.88e-041976752630_UP
Drugnovobiocin sodium, USP; Down 200; 100uM; PC3; HG-U133A

PHC3 ATXN2 RBL2 APAF1 LRP1

2.88e-04197675435_DN
DrugCefalonium [5575-21-3]; Down 200; 8.8uM; MCF7; HT_HG-U133A

MINK1 NUMB DLX2 BCOR SLC25A37

2.88e-041976757341_DN
DrugIndapamide [26807-65-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A

PRDM10 RBL2 APAF1 DYRK1A LYST

2.88e-041976753859_UP
DrugN-Acetyl-L-leucine [1188-21-2]; Up 200; 23uM; HL60; HT_HG-U133A

PTPRM MINK1 APAF1 DYRK1A DLX2

2.88e-041976753085_UP
DrugPromethazine hydrochloride [58-33-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A

MINK1 APAF1 LYST SLC25A37 RYR2

2.88e-041976755317_UP
DrugDoxylamine succinate [562-10-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A

HIPK3 NCOR1 CD22 MINK1 QSER1

2.88e-041976751473_DN
DrugTrimipramine maleate salt [521-78-8]; Down 200; 9.8uM; HL60; HT_HG-U133A

ZNF280A PHC3 RBFOX1 DYRK1A RYR2

2.88e-041976753004_DN
DrugThiorphan [76721-89-6]; Up 200; 15.8uM; MCF7; HT_HG-U133A

ZNF280A HIVEP3 PHC3 MINK1 TRPV4

2.88e-041976752752_UP
DrugPHA-00745360 [351320-33-7]; Up 200; 1uM; MCF7; HT_HG-U133A

PARP11 APAF1 TCF25 NUMB ASIC4

2.88e-041976753910_UP
DrugDihydroergotamine tartrate [5989-77-5]; Up 200; 3uM; MCF7; HT_HG-U133A

HIVEP3 NCOR2 CD22 RBFOX1 DLX2

2.88e-041976756840_UP
DrugGelsemine [509-15-9]; Down 200; 12.4uM; PC3; HT_HG-U133A

ZNF280A NCOR2 MINK1 APOBEC1 RYR2

2.88e-041976754097_DN
DrugMethantheline bromide [53-46-3]; Up 200; 9.6uM; HL60; HT_HG-U133A

HIPK3 DLG5 MINK1 APAF1 RFX1

2.88e-041976756137_UP
DrugBezafibrate [41859-67-0]; Up 200; 11uM; PC3; HT_HG-U133A

NCOR2 LRP1 PAPPA APOBEC1 ITGB8

2.88e-041976756653_UP
DrugChelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

NCOR2 PTPRM RBFOX1 LYST ITGB8

2.88e-041976752779_UP
DrugKhellin [82-02-0]; Down 200; 15.4uM; PC3; HT_HG-U133A

NCOR2 RBFOX1 LRP1 QSER1 RYR2

2.95e-041986756641_DN
DrugTridihexethyl chloride; Up 200; 11.4uM; PC3; HT_HG-U133A

PHC3 APAF1 LRP1 DLX2 RYR2

2.95e-041986755067_UP
DrugPropranolol hydrochloride [318-98-9]; Up 200; 13.6uM; MCF7; HT_HG-U133A

PHC3 RBFOX1 DYRK1A HIPK2 PAPPA

2.95e-041986753396_UP
DrugPhensuximide [86-34-0]; Up 200; 21.2uM; MCF7; HT_HG-U133A

ZNF280A PTPRM MINK1 HIPK2 ITGB8

2.95e-041986753521_UP
DrugTrichlorfon [52-68-6]; Down 200; 15.6uM; HL60; HT_HG-U133A

HIPK3 C7orf25 MINK1 NUMB SIK3

2.95e-041986751839_DN
DrugHA-1077 dihydrochloride; Down 200; 10uM; PC3; HG-U133A

NCOR2 PHC3 ATXN2 RBL2 SVIL

2.95e-04198675436_DN
DrugPhthalylsulfathiazole [85-73-4]; Up 200; 10uM; MCF7; HT_HG-U133A

PRDM10 CD22 MINK1 ASIC4 RFX1

2.95e-041986755614_UP
DrugPirenperone [ 75444-65-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A

CD22 PAPPA APOBEC1 CLSTN2 ASIC4

2.95e-041986755639_UP
DrugEstradiol-17 beta [50-28-2]; Down 200; 14.6uM; HL60; HT_HG-U133A

HIVEP3 PHC3 CD22 C7orf25 SVIL

2.95e-041986751299_DN
DrugPropranolol hydrochloride [318-98-9]; Up 200; 13.6uM; HL60; HT_HG-U133A

BNC2 MINK1 RBFOX1 TRPV4 DLX2

2.95e-041986753059_UP
DrugLisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; PC3; HT_HG-U133A

NCOR2 PHC3 RBFOX1 LRP1 QSER1

2.95e-041986756682_UP
DrugTorsemide [56211-40-6]; Down 200; 11.4uM; PC3; HT_HG-U133A

CD22 SVIL HIPK2 NUMB DLX2

3.02e-041996755057_DN
Drug2-propylpentanoic acid; Down 200; 50uM; HL60; HT_HG-U133A

HIVEP3 NCOR2 RBFOX1 DYRK1A HIPK2

3.02e-041996752682_DN
Drug(+,-)-Octopamine hydrochloride [770-05-8]; Up 200; 21uM; PC3; HT_HG-U133A

HIPK3 APAF1 DYRK1A QSER1 ITGB8

3.02e-041996755050_UP
DrugTrifluridine [70-00-8]; Up 200; 13.6uM; HL60; HT_HG-U133A

ZNF280A DLG5 PRDM10 CARF PAPPA

3.02e-041996756136_UP
DrugHarpagoside [19210-12-9]; Down 200; 8uM; MCF7; HT_HG-U133A

HIVEP3 DLG5 CLSTN2 SLC25A37 RYR2

3.02e-041996757355_DN
DrugNitrocaramiphen hydrochloride; Down 200; 10.8uM; HL60; HT_HG-U133A

HIVEP3 PARP11 CD22 MINK1 TMEM184C

3.02e-041996753125_DN
DrugLevamisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A

HIVEP3 PHC3 DLG5 MINK1 TCF25

3.02e-041996752257_DN
DrugTelenzepine dihydrochloride [147416-96-4]; Up 200; 9uM; HL60; HT_HG-U133A

PRDM10 DLX2 CLSTN2 ASIC4 RYR2

3.02e-041996752388_UP
DrugEtanidazole [22668-01-5]; Up 200; 18.6uM; MCF7; HT_HG-U133A

HIVEP3 BNC2 PHC3 CARF DLX2

3.02e-041996756072_UP
DrugIsocarboxazid [59-63-2]; Down 200; 17.2uM; PC3; HT_HG-U133A

NCOR2 PHC3 CD22 ATXN2 APAF1

3.02e-041996753684_DN
DrugBenzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; MCF7; HT_HG-U133A

PHC3 CD22 RBFOX1 APAF1 HIPK2

3.02e-041996753169_UP
DrugFinasteride [98319-26-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A

PHC3 MINK1 DLX2 APOBEC1 LYST

3.02e-041996753641_DN
DrugS-15

TRERF1 CLSTN2

3.03e-049672CID000095656
Drugtetraiodothyroacetic acid

NCOR1 NCOR2

3.03e-049672ctd:C011126
DrugCP-320650-01 [172079-28-6]; Up 200; 1uM; PC3; HT_HG-U133A

APAF1 LRP1 PAPPA RFX1 ITGB8

3.09e-042006753825_UP
DrugChlorzoxazone [95-25-0]; Up 200; 23.6uM; MCF7; HT_HG-U133A

ZNF280A NCOR2 CD22 QSER1 RYR2

3.09e-042006757456_UP
DrugAC1L3UEY

NCOR1 NCOR2 RFX1 MED12

3.47e-04113674CID000122342
Diseasemultiple sclerosis

TET2 NCOR2 SLC9B1 PTPRK ATXN2 SYDE2 SVIL MINK1 CLSTN2

5.25e-06594649MONDO_0005301
Diseaseintellectual disability (implicated_via_orthology)

ZNF280A RBL2 RBFOX1 DYRK1A

2.18e-0575644DOID:1059 (implicated_via_orthology)
Diseasecolorectal cancer, endometrial neoplasm

TET2 ATXN2 LITAF

1.05e-0442643EFO_0004230, MONDO_0005575
DiseaseColorectal Carcinoma

HIVEP3 TET2 TNNI3K FAT1 LRP1 CLSTN2 IQUB AMTN

1.35e-04702648C0009402
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

DMGDH NCOR2 SLC9B1 ATXN2 SIK3

1.73e-04239645EFO_0008317, EFO_0020945
Diseasebasophil count, eosinophil count

TRERF1 HIVEP3 ATXN2 SIK3 ITGB8

1.80e-04241645EFO_0004842, EFO_0005090
Diseasegeneralised epilepsy

PTPRK RBFOX1 RYR2

1.99e-0452643EFO_0005917
Diseaseallergic rhinitis

ATXN2 RBFOX1 SIK3 ITGB8

2.03e-04133644EFO_0005854
Diseaseforced expiratory volume

TET2 DMGDH NCOR1 BNC2 NCOR2 ANGPTL1 ITGB8 RYR2

2.98e-04789648EFO_0004314
Diseaseevent free survival time, type 1 diabetes mellitus, autoantibody measurement

ATXN2 RBFOX1

3.01e-0412642EFO_0000482, EFO_0004866, MONDO_0005147
Diseaseeosinophil count

TRERF1 HIVEP3 TET2 BNC2 NCOR2 PHC3 ATXN2 LITAF DYRK1A SIK3 ITGB8

3.27e-0414886411EFO_0004842
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

TET2 BNC2 TNNI3K PTPRK ATXN2 MINK1 RBFOX1 RYR2

3.29e-04801648EFO_0003888, EFO_0007052, MONDO_0002491
Diseaseputamen volume change measurement

TAF3 SYDE2

3.56e-0413642EFO_0021495
Diseasediastolic blood pressure, systolic blood pressure

BNC2 ATXN2 SVIL RBFOX1 SCYL1 LRP1 RYR2

6.10e-04670647EFO_0006335, EFO_0006336
Diseasemacula measurement

DLG5 FAT1 NUMB TTK

7.67e-04189644EFO_0008375
Diseaseserum gamma-glutamyl transferase measurement

DMGDH NCOR2 DLG5 PTPRM LITAF SVIL DYRK1A RYR2

7.85e-04914648EFO_0004532
Diseasemigraine disorder, Headache

CARF LRP1 PAPPA

8.76e-0486643HP_0002315, MONDO_0005277
Diseasevisceral adipose tissue measurement, body mass index

RBFOX1 CLSTN2 SIK3

9.06e-0487643EFO_0004340, EFO_0004765
Diseasedescending aortic diameter

SVIL LRP1 SIK3

9.36e-0488643EFO_0021788
Diseasemigraine disorder

NCOR2 SVIL CARF LRP1 PAPPA

1.07e-03357645MONDO_0005277
Diseaseeosinophil percentage of leukocytes

TRERF1 HIVEP3 BNC2 ATXN2 DYRK1A SIK3 ITGB8

1.14e-03746647EFO_0007991
DiseaseEczema, allergic rhinitis

BNC2 PTPRK ATXN2 ITGB8

1.24e-03215644EFO_0005854, HP_0000964
Diseaserisk-taking behaviour

HIVEP3 TET2 BNC2 TNNI3K PTPRM RBFOX1 RYR2

1.31e-03764647EFO_0008579
Diseaseresponse to bronchodilator, FEV/FEC ratio

TET2 BNC2 NCOR2 RBFOX1 CLSTN2 SIK3 LYST

1.33e-03766647EFO_0004713, GO_0097366
Diseasecreatinine measurement

TET2 DMGDH SLC9B1 PRRC2C SVIL NUMB TRPV4 ASIC4

1.35e-03995648EFO_0004518
Diseaseneutrophil percentage of granulocytes

TRERF1 HIVEP3 ATXN2 ITGB8

1.53e-03228644EFO_0007994
Diseaseeosinophil percentage of granulocytes

TRERF1 HIVEP3 ATXN2 ITGB8

1.69e-03234644EFO_0007996
Diseaseright ventricular diastolic volume measurement

ATXN2 RBL2

1.69e-0328642EFO_0021814
Diseaseeosinophil measurement

ATXN2 DYRK1A ITGB8

1.69e-03108643EFO_0803540
Diseasepappalysin‐1 measurement

ATXN2 PAPPA

1.81e-0329642EFO_0010618
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

DMGDH NCOR2 ATXN2 SIK3

1.94e-03243644EFO_0004612, EFO_0020944

Protein segments in the cluster

PeptideGeneStartEntry
VILQHLVHYTQPELQ

TMEM184C

66

Q9NVA4
QYPAHVSQPANHVTS

ZNF280A

81

P59817
ITQFQRYHQPHTLSP

APAF1

461

O14727
QNCHYQTIPPHILLA

APOBEC1

211

P41238
TQHLYHPTQVEIVQS

BNC2

151

Q6ZN30
VQVVPQHIPNSQQYT

ANGPTL1

216

O95841
VQQQLHPHVLPIFVT

AMTN

91

Q6UX39
THPVQETTFHVAPQQ

DYRK1A

581

Q13627
VNHLIVQPPFLQSVH

CLSTN2

801

Q9H4D0
SHAYPHIQNSKQPRV

BCOR

301

Q6W2J9
QIAASSTYHQHQQPP

DLX2

16

Q07687
LVQPHNVPSIVHSQV

QSER1

346

Q2KHR3
NNPITVQTVYVQHPI

LITAF

71

Q99732
SQNHPVYISPHKNET

RBL2

1051

Q08999
QVHSPVVHVQANSPE

FAT1

2196

Q14517
TQDYTRHHPQQLSAP

NCOR2

2141

Q9Y618
VQHTAYPASIVHQVP

HIPK2

1131

Q9H2X6
PEANVQTQHPHYSRE

EURL

206

Q9NYK6
VVLYHQHKQPEVTNP

LRP1

4136

Q07954
AQQTVFTIHPSHVQP

ATXN2

1221

Q99700
LPTQQAHQYHELETP

CARF

371

Q8N187
EVDEQPQHPLHVTYA

PEBP1

16

P30086
ITILAQYNPHVHQLS

DLG5

1421

Q8TDM6
HVQYATHFPIPQEES

MED12

731

Q93074
IRVQIHSQEEPPYIH

ASIC4

251

Q96FT7
PQPYPQHAIQVQHIQ

PRDM10

971

Q9NQV6
IPVVHDLSQPFYHSQ

PAPPA

1146

Q13219
TYNISHPSGIVHQVP

HIPK3

1151

Q9H422
SYSPIQPHSLIKHQQ

PHC3

296

Q8NDX5
VPYQLIPLHNQTHEY

PARP11

136

Q9NR21
VSPYISIHPERIHNQ

ITGB8

196

P26012
QASHQQPVQYSNPHI

C7orf25

151

Q9BPX7
HSPQSVPVHDIYVSQ

FRRS1

41

Q6ZNA5
LLAVHPPTNTYVCHN

LYST

2016

Q99698
SHVPLYPNSQPQVHL

MS4A8

31

Q9BY19
LEHPLIPVQHQYVVT

DMGDH

261

Q9UI17
EVISPRQVSYTPQHH

IQUB

81

Q8NA54
PQFLQVPSNHEHIEV

RYR2

1256

Q92736
QVQYAPEPSTVQILH

CD22

326

P20273
QHVVNHLPPYTNVSL

PTPRK

451

Q15262
HPQHTITNLSPYTNV

PTPRM

441

P28827
YIPVHIQSQITPHAI

MINK1

1201

Q8N4C8
HQSPSLVRQQTFPHY

NUMB

551

P49757
TNHPPSNLLYQEQHV

FER1L6

811

Q2WGJ9
NPIHPAHSTEFVQQY

SYDE2

441

Q5VT97
EDYIHNIEPVTFPHQ

TAF3

81

Q5VWG9
HTLNLYPPAQTHSEQ

RBFOX1

61

Q9NWB1
RHQPAPVHYVSFQSE

SVIL

331

O95425
DEPTVNTQIFPHVVH

SCYL1

381

Q96KG9
ITIAYGTNNVHPPQH

NXPE4

516

Q6UWF7
QLQQVPVPHVYSSQV

RFX1

281

P22670
YSPESQAQSVHHQRP

NCOR1

2101

O75376
VNPHRTYNPQSHIIS

SLC25A37

226

Q9NYZ2
QQTSNTQPIPILYEH

PRRC2C

2511

Q9Y520
HQQPPHYTTSALQQA

SIK3

936

Q9Y2K2
QATQIVPHQGQYLHP

SHISA2

231

Q6UWI4
AAAHQVQVLPYPFTH

UTP14C

676

Q5TAP6
LHEQVHQGPVPLSYT

RNF44

96

Q7L0R7
PYTEALQVFHHPVAQ

HIVEP3

1116

Q5T1R4
YQNIKPQHYPSIHIT

PREPL

626

Q4J6C6
IRNVPFINEHVHVPN

SLC9B1

136

Q4ZJI4
LAHPYVQIQTHPVNQ

TTK

786

P33981
QQQPHHPQTESVNSY

TET2

1546

Q6N021
VQPHVVNIYGDTPLH

TNNI3K

261

Q59H18
LVTHQVVHTGQRPYP

ZNF425

261

Q6IV72
EPNNIVVLLQTSPYH

TCF25

271

Q9BQ70
NQPHIVNYLTENPHK

TRPV4

296

Q9HBA0
HQYTPEQAHTVQLIP

TRERF1

356

Q96PN7