Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP hydrolysis activity

ATP8B3 ABCC4 ATP6V1G3 ABCA13 KIF1B MCM7 DNAH7 DDX27 RAD50

3.57e-05441749GO:0016887
GeneOntologyMolecularFunctionATP-dependent activity

ATP8B3 ABCC4 ATP6V1G3 ABCA13 KIF1B MCM7 DNAH7 DDX27 DNAH1 RAD50

8.58e-056147410GO:0140657
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ATP8B3 ABCC4 ATP6V1G3 ABCA13 KIF1B DNM3 MCM7 DNAH7 DDX27 RAD50

5.56e-047757410GO:0017111
GeneOntologyMolecularFunctionlipid transporter activity

ANO4 ATP8B3 ABCC4 ABCA13 ANO1

8.06e-04196745GO:0005319
GeneOntologyMolecularFunctionkinase binding

PTK2B STX1A PER3 KIF1B DNM3 ZFYVE26 SPAG9 MAPK1 TRIM22 MAPK8IP3 IFNAR2

8.41e-049697411GO:0019900
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ANO4 ATP8B3 ANO1

8.95e-0451743GO:0140303
GeneOntologyMolecularFunctionpyrophosphatase activity

ATP8B3 ABCC4 ATP6V1G3 ABCA13 KIF1B DNM3 MCM7 DNAH7 DDX27 RAD50

1.02e-038397410GO:0016462
GeneOntologyMolecularFunctionMAP-kinase scaffold activity

SPAG9 MAPK8IP3

1.03e-0313742GO:0005078
GeneOntologyMolecularFunctioncalcium channel inhibitor activity

STX1A YWHAE

1.03e-0313742GO:0019855
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ATP8B3 ABCC4 ATP6V1G3 ABCA13 KIF1B DNM3 MCM7 DNAH7 DDX27 RAD50

1.03e-038407410GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ATP8B3 ABCC4 ATP6V1G3 ABCA13 KIF1B DNM3 MCM7 DNAH7 DDX27 RAD50

1.03e-038407410GO:0016818
GeneOntologyMolecularFunctionkinesin binding

KIF1B SPAG9 MAPK8IP3

1.12e-0355743GO:0019894
GeneOntologyMolecularFunctionsignaling adaptor activity

SPAG9 YWHAE MAPK8IP3 IFNAR2

1.35e-03129744GO:0035591
GeneOntologyMolecularFunctionJUN kinase binding

SPAG9 MAPK8IP3

1.78e-0317742GO:0008432
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH7 DNAH1

1.99e-0318742GO:0008569
GeneOntologyMolecularFunctionprotein phosphorylated amino acid binding

PIK3R3 MAPK1 YWHAE

2.15e-0369743GO:0045309
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF1B DNAH7 DNAH1

2.24e-0370743GO:0003777
GeneOntologyMolecularFunctionintracellularly calcium-gated channel activity

ANO4 ANO1

2.47e-0320742GO:0141147
GeneOntologyMolecularFunctionintracellularly calcium-gated chloride channel activity

ANO4 ANO1

2.47e-0320742GO:0005229
GeneOntologyMolecularFunctionphospholipid transporter activity

ANO4 ATP8B3 ANO1

2.62e-0374743GO:0005548
GeneOntologyBiologicalProcessnegative regulation of BMP signaling pathway

LEMD3 SKOR2 LEMD2 SMURF1 SKOR1

1.01e-0580745GO:0030514
GeneOntologyBiologicalProcessnegative regulation of cellular response to growth factor stimulus

LEMD3 SKOR2 LEMD2 SMURF1 SKOR1 ADGRA2

1.65e-05150746GO:0090288
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle recycling

ABCA13 DNM3 MFF

2.91e-0517743GO:1903423
GeneOntologyBiologicalProcesssynaptic vesicle cycle

STX1A ATP6V1G3 ABCA13 ERC1 DNM3 CPLX4 MFF

4.50e-05264747GO:0099504
GeneOntologyBiologicalProcessBMP signaling pathway

LEMD3 SKOR2 LEMD2 SMURF1 SKOR1 DSG4

7.60e-05197746GO:0030509
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

LEMD3 SKOR2 LEMD2 SMURF1 SKOR1

1.09e-04131745GO:0030510
GeneOntologyBiologicalProcessresponse to BMP

LEMD3 SKOR2 LEMD2 SMURF1 SKOR1 DSG4

1.23e-04215746GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

LEMD3 SKOR2 LEMD2 SMURF1 SKOR1 DSG4

1.23e-04215746GO:0071773
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

STX1A ATP6V1G3 ABCA13 ERC1 DNM3 CPLX4 MFF

1.53e-04321747GO:0099003
GeneOntologyBiologicalProcesssperm axoneme assembly

CCDC146 CFAP44 DNAH1

2.45e-0434743GO:0007288
GeneOntologyBiologicalProcessinsulin receptor signaling pathway

STXBP4 PIK3R3 SIK2 PLCB1 MAPK1

2.46e-04156745GO:0008286
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

PTK2B LEMD3 STXBP4 SKOR2 PIK3R3 LEMD2 SMURF1 SKOR1 SIK2 PLCB1 DSG4 MAPK1 ADGRA2

2.77e-0411867413GO:0007167
GeneOntologyCellularComponentsecretory vesicle

ATP8B3 ABCC4 STX1A ATP6V1G3 WDR7 ABCA13 ERC1 GUSB SPATA16 KIF1B SPAG9 MAPK1 ITGAL MFF MCEMP1

2.56e-0512467415GO:0099503
GeneOntologyCellularComponentinner dynein arm

DNAH7 DNAH1

5.46e-0410742GO:0036156
GeneOntologyCellularComponentsynaptic vesicle

STX1A ATP6V1G3 WDR7 ERC1 KIF1B MFF

6.79e-04300746GO:0008021
GeneOntologyCellularComponentU2-type precatalytic spliceosome

SF3B1 TXNL4A CWC22

7.85e-0451743GO:0071005
GeneOntologyCellularComponentprecatalytic spliceosome

SF3B1 TXNL4A CWC22

9.28e-0454743GO:0071011
GeneOntologyCellularComponentexocytic vesicle

STX1A ATP6V1G3 WDR7 ERC1 KIF1B MFF

9.49e-04320746GO:0070382
GeneOntologyCellularComponentpresynapse

PTK2B STX1A ATP6V1G3 WDR7 ERC1 KIF1B ANO1 DNM3 CPLX4 MFF

1.09e-038867410GO:0098793
MousePhenoabnormal blood-cerebrospinal fluid barrier function

ABCC4 ADGRA2

2.13e-052652MP:0006088
DomainMSC

LEMD3 LEMD2

1.47e-052722PF09402
DomainJIP_LZII

SPAG9 MAPK8IP3

1.47e-052722IPR032486
DomainInner-Nucl-membr_MAN1

LEMD3 LEMD2

1.47e-052722IPR018996
DomainJIP_LZII

SPAG9 MAPK8IP3

1.47e-052722PF16471
Domainc-SKI_SMAD4-bd_dom

SKOR2 SKOR1

8.75e-054722IPR014890
DomainTscrpt_reg_SKI_SnoN

SKOR2 SKOR1

8.75e-054722IPR023216
DomainJnk-SapK_ap_N

SPAG9 MAPK8IP3

8.75e-054722PF09744
Domainc-SKI_SMAD_bind

SKOR2 SKOR1

8.75e-054722PF08782
DomainJNK/Rab-associated_protein-1_N

SPAG9 MAPK8IP3

8.75e-054722IPR019143
Domainc-SKI_SMAD_bind

SKOR2 SKOR1

8.75e-054722SM01046
DomainLEM

LEMD3 LEMD2

1.45e-045722SM00540
DomainRH2

SPAG9 MAPK8IP3

1.45e-045722PS51777
DomainRH1

SPAG9 MAPK8IP3

1.45e-045722PS51776
DomainLEM/LEM-like_dom

LEMD3 LEMD2

3.04e-047722IPR011015
DomainLEM_dom

LEMD3 LEMD2

3.04e-047722IPR003887
DomainLEM

LEMD3 LEMD2

3.04e-047722PS50954
DomainAnoct_dimer

ANO4 ANO1

3.04e-047722PF16178
DomainAnoct_dimer

ANO4 ANO1

3.04e-047722IPR032394
DomainSki_Sno

SKOR2 SKOR1

3.04e-047722PF02437
Domain-

SKOR2 SKOR1

3.04e-0477223.10.260.20
DomainTransform_Ski

SKOR2 SKOR1

3.04e-047722IPR003380
Domain-

LEMD3 LEMD2

3.04e-0477221.10.720.40
DomainLEM

LEMD3 LEMD2

3.04e-047722PF03020
DomainAnoctamin

ANO4 ANO1

6.46e-0410722PF04547
DomainAnoctamin

ANO4 ANO1

6.46e-0410722IPR007632
DomainDNA-bd_dom_put

SKOR2 SKOR1

7.88e-0411722IPR009061
Domain-

PTK2B NF2 ACBD5

8.91e-04497231.20.80.10
Domain-

SKOR2 SKOR1

9.43e-04127223.10.390.10
DomainSAND_dom-like

SKOR2 SKOR1

9.43e-0412722IPR010919
DomainFERM/acyl-CoA-bd_prot_3-hlx

PTK2B NF2 ACBD5

9.45e-0450723IPR014352
DomainDynein_heavy_chain_D4_dom

DNAH7 DNAH1

1.29e-0314722IPR024317
DomainDynein_HC_stalk

DNAH7 DNAH1

1.29e-0314722IPR024743
DomainDynein_heavy_dom-2

DNAH7 DNAH1

1.29e-0314722IPR013602
DomainDHC_N2

DNAH7 DNAH1

1.29e-0314722PF08393
DomainMT

DNAH7 DNAH1

1.29e-0314722PF12777
DomainAAA_8

DNAH7 DNAH1

1.29e-0314722PF12780
DomainDHC_fam

DNAH7 DNAH1

1.49e-0315722IPR026983
DomainDynein_heavy_dom

DNAH7 DNAH1

1.49e-0315722IPR004273
DomainDynein_heavy

DNAH7 DNAH1

1.49e-0315722PF03028
DomainAAA+_ATPase

ABCC4 ABCA13 MCM7 DNAH7

2.32e-03144724IPR003593
DomainAAA

ABCC4 ABCA13 MCM7 DNAH7

2.32e-03144724SM00382
Domain-

GPD2 CALU STXBP4 PLCB1 NINL

3.35e-032617251.10.238.10
DomainEF_Hand_1_Ca_BS

GPD2 CALU NINL DNAH7

4.67e-03175724IPR018247
DomainEF-hand-dom_pair

GPD2 CALU STXBP4 PLCB1 NINL

5.00e-03287725IPR011992
DomainP-loop_NTPase

ABCC4 ABCA13 KIF1B DNM3 MCM7 DNAH7 DDX27 DNAH1 RAD50

5.15e-03848729IPR027417
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

GPD2 CNNM4 NF2 LEMD3 ERC1 CALU CIP2A STXBP4 PIK3R3 ACBD5 BRD3 SPAG9 MAPK1 YWHAE DDX27 HDLBP

5.47e-101049741627880917
Pubmed

Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation.

LEMD3 LEMD2 MAPK1

9.22e-08574319720741
Pubmed

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

BLVRA FGFR1OP2 SF3B1 DNM3 MCM7 SPAG9 MAPK8IP3

1.19e-0718074730110629
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

GPD2 BLVRA CNNM4 DYM SF3B1 CALU GUSB CIP2A PIGS LEMD2 MCM7 EIF3H YWHAE DDX27 RAD50

3.06e-071440741530833792
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

GBF1 ERC1 SIK2 DNM3 PLCB1 SPAG9 ADGRA2

5.38e-0722574712168954
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

SF3B1 NF2 WDR7 CCDC146 LEMD3 KIF1B ACBD5 MCM7 SPAG9 DNAH7 MFF

7.50e-07777741135844135
Pubmed

Defining the membrane proteome of NK cells.

ABCC4 GBF1 NF2 CALU GUSB PIGS LEMD2 ACBD5 MCM7 EIF3H ITGAL YWHAE RAD50

1.01e-061168741319946888
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

GPD2 ABCC4 LEMD3 CALU BRD3 CWC22 YWHAE MFF

1.46e-0637874834315543
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TRAF3IP2 CNNM4 RIOK1 ERC1 CIP2A PIGS KIF1B NINL MCM7 SPAG9 TSPYL4 YWHAE RAD50

3.91e-061321741327173435
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ERC1 CIP2A STXBP4 KIF1B MCM7 TACC2 CFAP44 HDLBP RAD50

4.42e-0658874938580884
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

DYM ERC1 PIGS STXBP4 NINL MAPK1 EIF3H DDX27 HDLBP RAD50

4.45e-06754741033060197
Pubmed

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.

SPAG9 MAPK8IP3

4.47e-06274231690808
Pubmed

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.

SPAG9 MAPK8IP3

4.47e-06274233788575
Pubmed

Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells.

PLCB1 MAPK1

4.47e-06274211481231
Pubmed

Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL.

SKOR2 SKOR1

4.47e-06274231530634
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

FGFR1OP2 GBF1 NF2 ERC1 STXBP4 KIF1B NINL YWHAE

4.94e-0644674824255178
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

RIOK1 GBF1 SF3B1 ERC1 CALU CIP2A MCM7 SPAG9 EIF3H YWHAE HDLBP RAD50

5.30e-061149741235446349
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

GPD2 PTK2B STX1A ERC1 KIF1B MCM7 MAPK1 YWHAE HDLBP

6.85e-0662174922794259
Pubmed

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.

STX1A NF2 ERC1 MAPK1 ITGAL CWC22

7.55e-0621974629997244
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

STX1A ERC1 KIF1B DNM3 SPAG9

8.20e-0612874530995482
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

GPD2 RIOK1 SF3B1 TXNL4A ERC1 SPC25 MCM7 TACC2 MAPK1 EIF3H YWHAE HDLBP RAD50

8.21e-061415741328515276
Pubmed

The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.

GPD2 NF2 LEMD2 MAPK1 EIF3H YWHAE HDLBP

9.94e-0635074726549023
Pubmed

Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).

SPAG9 MAPK1 MAPK8IP3

1.03e-052074312897243
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

GPD2 ABCC4 GBF1 WDR7 LEMD3 PIGS ACBD5 MFF

1.20e-0550474834432599
Pubmed

Integration of B-cell receptor-induced ERK1/2 phosphorylation and mutations of SF3B1 gene refines prognosis in treatment-naïve chronic lymphocytic leukemia.

SF3B1 MAPK1

1.34e-05374227927769
Pubmed

Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.

BLVRA MAPK1

1.34e-05374218463290
Pubmed

The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.

SPAG9 MAPK8IP3

1.34e-05374220493856
Pubmed

JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration.

SPAG9 MAPK8IP3

1.34e-05374225571974
Pubmed

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation.

PTK2B ITGAL

1.34e-05374228699640
Pubmed

JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.

SPAG9 MAPK8IP3

1.34e-05374225130574
Pubmed

Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.

PTK2B ITGAL

1.34e-05374220805505
Pubmed

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.

STX1A ANO1

1.34e-05374224885604
Pubmed

Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice.

SPAG9 MAPK8IP3

1.34e-05374226320416
Pubmed

Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.

SPAG9 MAPK1 MAPK8IP3

1.38e-052274315767678
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

ATP8B3 PTK2B ATP6V1G3 RIOK1 SMURF1 PLCB1 BRD3 MAPK1 YWHAE

2.46e-0573074934857952
Pubmed

Computational analysis of mRNA expression profiles identifies the ITG family and PIK3R3 as crucial genes for regulating triple negative breast cancer cell migration.

PIK3R3 ITGAL

2.67e-05474224982892
Pubmed

Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.

PTK2B MAPK1

2.67e-05474220180987
Pubmed

TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.

MAPK1 TRIM22

2.67e-05474237258577
Pubmed

HIV Nef inhibits T cell migration.

PTK2B MAPK1

2.67e-05474212354773
Pubmed

Oligogenic heterozygous inheritance of sperm abnormalities in mouse.

CCDC146 CFAP44

2.67e-05474235451961
Pubmed

Role of plasma membrane localization of the scaffold protein JSAP1 during differentiation of cerebellar granule cell precursors.

MAPK1 MAPK8IP3

2.67e-05474221156008
Pubmed

Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.

SPAG9 MAPK8IP3

2.67e-05474211106729
Pubmed

Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.

MAPK1 MAPK8IP3

2.67e-05474215537893
Pubmed

Nuclear phosphoinositide-specific phospholipase C β1 controls cytoplasmic CCL2 mRNA levels in HIV-1 gp120-stimulated primary human macrophages.

PLCB1 MAPK1

2.67e-05474223555755
Pubmed

Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2.

PTK2B MAPK1

2.67e-05474214676843
Pubmed

LFA-1 and CD2 synergize for the Erk1/2 activation in the Natural Killer (NK) cell immunological synapse.

MAPK1 ITGAL

2.67e-05474219502238
Pubmed

FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.

ANO4 ANO1

2.67e-05474212739008
Pubmed

LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways.

MAPK1 ITGAL

2.67e-05474219483086
Pubmed

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

BLVRA CNNM4 DYM CALU CIP2A STXBP4 MAPK1 YWHAE MFF RAD50

2.75e-05931741027432908
Pubmed

New gene functions in megakaryopoiesis and platelet formation.

ABCC4 KIF1B DNM3 BRD3

2.77e-058174422139419
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

GBF1 LEMD3 ERC1 CIP2A ACBD5 SPAG9 MFF HDLBP

2.82e-0556874837774976
Pubmed

Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein.

SF3B1 PLCB1 MCM7 HDLBP RAD50

3.14e-0516974523665500
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

GBF1 CIP2A DNM3 MAPK1 YWHAE HDLBP

3.54e-0528874623383273
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

CNNM4 GBF1 LEMD3 CIP2A STXBP4 SPAG9 MAPK1 YWHAE DDX27 RAD50

4.02e-05974741028675297
Pubmed

Balancing BMP signaling through integrated inputs into the Smad1 linker.

SMURF1 MAPK1

4.45e-05574217289590
Pubmed

Multiple Mechanisms Cooperate to Constitutively Exclude the Transcriptional Co-Activator YAP from the Nucleus During Murine Oogenesis.

NF2 MAPK1

4.45e-05574226985001
Pubmed

Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.

PTK2B MAPK1

4.45e-05574212943720
Pubmed

Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.

DNAH7 DNAH1

4.45e-05574239056782
Pubmed

Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.

SIK2 YWHAE

4.45e-05574224129571
Pubmed

Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer.

MAPK1 MAPK8IP3

4.45e-05574212661038
Pubmed

Monoubiquitination of p120-catenin is essential for TGFβ-induced epithelial-mesenchymal transition and tumor metastasis.

SMURF1 MAPK1

4.45e-05574232010791
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

GPD2 RIOK1 GBF1 SF3B1 CALU MCM7 EIF3H CWC22 YWHAE DDX27 HDLBP RAD50

4.46e-051425741230948266
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

GPD2 PTK2B SF3B1 WDR7 ERC1 KIF1B SMURF1 ALDH1L1 MAPK1 YWHAE MAPK8IP3 HDLBP

4.65e-051431741237142655
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

RIOK1 SF3B1 CALU GUSB PIGS MCM7 YWHAE RAD50

4.83e-0561374822268729
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

RIOK1 CIP2A PLCB1 NINL CFAP44

5.08e-0518774526460568
Pubmed

Global landscape of HIV-human protein complexes.

PTK2B CALU ACBD5 MCM7 EIF3H ITGAL YWHAE

5.45e-0545774722190034
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

GBF1 SF3B1 CIP2A MCM7 SPAG9 EIF3H YWHAE RAD50

6.38e-0563874833239621
Pubmed

The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity.

PTK2B MAPK1

6.66e-05674218667434
Pubmed

The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties.

NF2 MAPK1

6.66e-05674210675333
Pubmed

Identification and characterization of TMEM16E and TMEM16F genes in silico.

ANO4 ANO1

6.66e-05674215067359
Pubmed

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins.

SPAG9 MAPK8IP3

6.66e-05674220173330
Pubmed

Pyk2/ERK 1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor.

PTK2B MAPK1

6.66e-05674218365874
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

SF3B1 NF2 LEMD3 CALU GUSB CIP2A STXBP4 PIK3R3 ACBD5 SIK2 DDX27 HDLBP

6.72e-051487741233957083
Pubmed

Centrosome-related genes, genetic variation, and risk of breast cancer.

MCM7 TACC2 MAPK1 YWHAE

6.85e-0510274420508983
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

CCDC146 CIP2A KIF1B ADGRA2

7.12e-0510374410819331
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

RIOK1 SF3B1 TXNL4A CALU MCM7 EIF3H ITGAL DDX27

7.50e-0565374833742100
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

WDR7 KIF1B PLCB1 SPAG9

7.67e-051057449628581
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

RIOK1 ERC1 CIP2A STXBP4 KIF1B NINL DNAH7 DDX27 RAD50

8.19e-0585374928718761
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

CNNM4 GBF1 SF3B1 ERC1 KIF1B MCM7 SPAG9 EIF3H DDX27 HDLBP RAD50

8.24e-051284741117353931
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PTK2B GBF1 ERC1 CALU STXBP4 KIF1B SIK2 DNAH7 YWHAE

8.79e-0586174936931259
Pubmed

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.

ANO4 ANO1

9.31e-05774222075693
Pubmed

14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.

SMURF1 YWHAE MFF

1.00e-044274323444366
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

GBF1 ERC1 CIP2A YWHAE HDLBP

1.00e-0421674531519766
Pubmed

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

GPD2 ABCC4 SF3B1 CALU MCM7 SPAG9 MAPK1 EIF3H YWHAE

1.02e-0487874937223481
Pubmed

Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.

ERC1 SMURF1 MCM7 DDX27

1.17e-0411774434662580
Pubmed

Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.

NF2 MAPK1

1.24e-04874233331896
Pubmed

MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha.

MAPK1 YWHAE

1.24e-04874215284227
Pubmed

Anoctamins are a family of Ca2+-activated Cl- channels.

ANO4 ANO1

1.24e-04874222946059
Pubmed

Thrombin Enhanced Matrix Metalloproteinase-9 Expression and Migration of SK-N-SH Cells via PAR-1, c-Src, PYK2, EGFR, Erk1/2 and AP-1.

PTK2B MAPK1

1.24e-04874227181591
Pubmed

Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entry.

PTK2B PLCB1

1.24e-04874218632858
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

GPD2 BLVRA GBF1 SF3B1 CALU KIF1B MCM7 MAPK1 YWHAE HDLBP RAD50

1.43e-041367741132687490
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

FGFR1OP2 STX1A SF3B1 ERC1 ACBD5 PLCB1 TACC2 YWHAE MAPK8IP3 HDLBP

1.46e-041139741036417873
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

SF3B1 LEMD3 ERC1 ACBD5 DDX27 HDLBP

1.51e-0437574632788342
Pubmed

Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.

STX1A ABCA13 ERC1

1.59e-044974331609468
Pubmed

P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.

ERC1 MAPK1

1.59e-04974219555761
Pubmed

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.

NF2 MAPK1

1.59e-04974220643348
Pubmed

Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.

SIK2 YWHAE

1.59e-04974224841198
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

SF3B1 PER3 LEMD3 CALU STXBP4 SPC25 TACC2 SPAG9 EIF3H CWC22

1.64e-041155741020360068
Pubmed

Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation.

STX1A DNM3

1.99e-041074210398046
Pubmed

Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases.

LEMD2 MAPK1

1.99e-041074225790465
InteractionARL10 interactions

NF2 LEMD3 KIF1B ACBD5 MCM7 SPAG9 MFF

6.05e-06189747int:ARL10
InteractionKIF11 interactions

RIOK1 GBF1 ACBD5 SMURF1 DNM3 NINL EIF3H HDLBP

6.05e-06267748int:KIF11
InteractionCCDC88C interactions

SMURF1 NINL MCM7 ALDH1L1 YWHAE

6.27e-0671745int:CCDC88C
InteractionEP300 interactions

BLVRA FGFR1OP2 RIOK1 SF3B1 TXNL4A CALU SIK2 DNM3 MCM7 TACC2 SPAG9 MAPK1 EIF3H ITGAL DDX27 MAPK8IP3 RAD50

9.66e-0614017417int:EP300
InteractionLRRC39 interactions

CNNM4 NINL RAD50

1.02e-0512743int:LRRC39
InteractionH4C15 interactions

RIOK1 NINL BRD3 YWHAE

1.69e-0542744int:H4C15
InteractionFBXO42 interactions

ERC1 CIP2A KIF1B SMURF1 TACC2 CFAP44 HDLBP

4.61e-05259747int:FBXO42
InteractionDCTN2 interactions

GBF1 ERC1 KIF1B SMURF1 NINL MCM7 EIF3H MAPK8IP3

4.79e-05356748int:DCTN2
InteractionACTR1A interactions

RIOK1 CIP2A SMURF1 NINL MCM7 SPAG9 YWHAE

6.58e-05274747int:ACTR1A
InteractionTRIM16 interactions

KIF1B MCM7 MAPK1 RAD50

7.95e-0562744int:TRIM16
CytobandEnsembl 112 genes in cytogenetic band chr18q21

DYM WDR7 SKOR2 CPLX4

3.48e-04205744chr18q21
GeneFamilySKI transcriptional corepressors

SKOR2 SKOR1

3.00e-054412748
GeneFamilyLEM domain containing

LEMD3 LEMD2

1.05e-0474121087
GeneFamilyAnoctamins

ANO4 ANO1

2.23e-0410412865
GeneFamilyDyneins, axonemal

DNAH7 DNAH1

6.68e-0417412536
GeneFamilyEF-hand domain containing

GPD2 CALU NINL DNAH7

1.49e-03219414863
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTK2B NF2

5.74e-03504121293
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

PTK2B TRIM22

5.96e-0351412870
CoexpressionRODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP

FGFR1OP2 SF3B1 CALU CIP2A SMURF1 PLCB1 MCM7 MAPK1 CWC22 DDX27 RAD50

5.47e-067217411M10237
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 ABCA13 DNM3 PLCB1 DNAH7

1.56e-05191735d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellCV-Healthy-2|Healthy / Virus stimulation, Condition and Cluster

ABCC4 RIOK1 CIP2A SPC25 MCM7

1.59e-05192735a249787f7e2f50af49bd7d4752c411a067a5e3d3
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 ABCA13 DNM3 PLCB1 DNAH7

1.68e-05194735e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ANO4 CIP2A SPC25 ANO1 MCM7

1.68e-05194735590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCellMild/Remission-Plasmablast|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ABCC4 CALU GUSB HDLBP IFNAR2

1.72e-0519573552bdd609253613b7db75dccbc1c01c05e8d73f79
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 ALDH1L1 CFAP44 DNAH7

1.80e-0519773591637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 ALDH1L1 CFAP44 DNAH7

1.80e-0519773522c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 ALDH1L1 CFAP44 DNAH7

1.80e-051977353bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 ALDH1L1 CFAP44 DNAH7

1.80e-0519773587db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 ALDH1L1 CFAP44 DNAH7

1.85e-05198735d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP4 SPC25 SKOR1 MCEMP1

3.59e-05113734ec4b89e727e1b921b9cb17443774955b95814dd4
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Ntng1_(Entopeduncular_Nucleus_(Ent)_or_Zona_Incerta,_ventral_part_(ZIV)._State_signal?)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ATP8B3 SKOR1 CFAP44

1.07e-0456733ad76712e6a99072f9c6dab6d746db54f754e14fd
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Ntng1_(Entopeduncular_Nucleus_(Ent)_or_Zona_Incerta,_ventral_part_(ZIV)._State_signal?)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ATP8B3 SKOR1 CFAP44

1.07e-045673320a2977f41d3ecbc4fbee7ecd6dfb4b7ce0e4bb7
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

STX1A PIK3R3 ITGAL DNAH7

1.11e-041517340cc2f4aec3dae4603fa831f22c40f897e68b34e2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

STX1A PIK3R3 ITGAL DNAH7

1.11e-04151734b545823113a3450c5f841f7de48bf0937593544f
ToppCellLPS-IL1RA-Myeloid_granulocytic|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GBF1 ABCA13 ITGAL TSPYL4

1.20e-04154734d55fb73461885e1e02061a344ff89624ef4de487
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC146 CFAP44 DNAH7 DNAH1

1.20e-041547349ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS-IL1RA-Myeloid_granulocytic-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GBF1 ABCA13 ITGAL TSPYL4

1.20e-0415473443735f7c58cac51855ded486ee8d8729a1b9909e
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC146 CFAP44 DNAH7 DNAH1

1.20e-0415473458072ce422d09f2de602580325eaac6c4ec6c136
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC146 CFAP44 DNAH7 DNAH1

1.23e-041557345f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC146 CFAP44 DNAH7 DNAH1

1.23e-041557340944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTK2B PLCB1 ITGAL TRIM22

1.29e-04157734170197b76620df31495f1247f365da382b2d8045
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTK2B PLCB1 ITGAL TRIM22

1.29e-04157734c21520301cc0d5d4b1cc4b8ec735f9adb698e768
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTK2B PLCB1 ITGAL TRIM22

1.32e-041587347274f020c0ecf216da4b6689c62bc5f49c29b6f3
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

KIF1B ACBD5 PLCB1 SPAG9

1.42e-04161734347edb0de10850b7d16c40945751033289289c9b
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CIP2A SPC25 ITGAL MCEMP1

1.56e-041657341dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCellPND01-03-samps-Myeloid|PND01-03-samps / Age Group, Lineage, Cell class and subclass

BLVRA PTK2B ITGAL MCEMP1

1.60e-0416673499dc8a186ec12d3563e81fa4618a814740332c73
ToppCell343B-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CIP2A SPC25 PLCB1 MCM7

1.63e-041677343461d14e36f09ddc6ee5549ca4797e16d3f37fcc
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

1.71e-0416973414aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellCiliated_cells-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

CCDC146 ABCA13 CFAP44 DNAH7

1.83e-04172734187ae91148d293537afc77e10da2b64302322224
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

1.87e-04173734c3762655caa79ac4879876f470d32578a3c93b01
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Lymphocytic-T|bone_marrow / Manually curated celltypes from each tissue

PTK2B CALU MCM7 MCEMP1

1.91e-041747341e289b26e2c29dbad15b712a999b96c391a26129
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.00e-04176734dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM7 RENBP ITGAL MCEMP1

2.00e-04176734270d7908dbd84028958d257f94941dc685e20255
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CIP2A SPC25 MCM7 MCEMP1

2.13e-04179734e1bfd553c043ebc070ccf8545d489ba16d9b2ef4
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.17e-041807341f1af4474f3f0ac3c0d6b1a6c875c354d36d8eec
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Ependyma|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC146 RENBP ALDH1L1 DNAH1

2.17e-04180734729f0d7af573c7796d8e28e6eec3af2fc0bd33a2
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-ependymal_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC146 RENBP ALDH1L1 DNAH1

2.17e-041807349ef79a7c60227e352ac166c7274adb31f585f5ca
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SKOR1 TMEM266 CFAP44

2.26e-04727337877184d5c9dd6d96476d71e7504e58c0b4d0f26
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BLVRA RENBP ITGAL MCEMP1

2.27e-0418273457f8b8d7b132f3ad6f2b1e79c3812fe938657d2c
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GPD2 CNNM4 SPC25 TSPYL4

2.32e-0418373491079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-MPO+_mono-neutrophil|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA13 GUSB CIP2A MCEMP1

2.32e-0418373401c7f01498a9894920edf8243e41187cbdf90688
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STXBP4 PLCB1 NINL ALDH1L1

2.36e-04184734e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 ABCA13 DNM3 DNAH7

2.36e-04184734da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STXBP4 PLCB1 NINL TMEM266

2.41e-0418573403f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

PIK3R3 SPC25 DNM3 PLCB1

2.41e-04185734f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANO4 GPD2 CNNM4 ABCC4

2.46e-04186734a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERC1 KIF1B SKOR1 TMEM266

2.46e-04186734a1ab273b01971d6a892912560d387685dd657179
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BLVRA GUSB RENBP MCEMP1

2.46e-04186734cb7df8da6478b96955f3ef1394a0655ec8061bba
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STXBP4 PLCB1 NINL ALDH1L1

2.51e-04187734b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2|lymph-node_spleen / Manually curated celltypes from each tissue

KIF1B ZFYVE26 ADGRA2 MCEMP1

2.51e-041877343c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA13 PLCB1 DNAH7 MAPK8IP3

2.51e-04187734c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ANO4 GPD2 CNNM4 ABCC4

2.57e-04188734e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.62e-04189734b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

IYD SIK2 TACC2 ALDH1L1

2.62e-04189734a48df46274d51e84ffb40264646de7346104efb9
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

CCDC146 ABCA13 CFAP44 DNAH7

2.62e-041897343e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA13 DNM3 PLCB1 DNAH7

2.67e-041907343fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

ABCC4 SPC25 DNM3 PLCB1

2.67e-0419073478e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STXBP4 PLCB1 NINL ALDH1L1

2.67e-04190734cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCellwk_20-22-Hematologic_Lymphocytic-NK-Cycling_NK|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ATP6V1G3 CIP2A SPC25 MCM7

2.72e-041917345d4fed25bd318472a17228b12ade4c331865bda5
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.72e-04191734683e5c7e6173644f01e67c98ab7b75d7cb9cce99
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STXBP4 PLCB1 TMEM266 ADGRA2

2.72e-041917341626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STXBP4 PLCB1 TMEM266 ADGRA2

2.72e-04191734716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CCDC146 ABCA13 CFAP44 DNAH7

2.72e-04191734e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCellCiliated-cil-3|World / Class top

CCDC146 ITGAL CFAP44 DNAH1

2.78e-041927344989ebb8812b8af1870599acd932849122c05a29
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ALDH1L1 CFAP44 DNAH7

2.78e-041927341b6cac8156e608061e1405e36e18d185b6fa8f6f
ToppCell15-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

CCDC146 ABCA13 CFAP44 DNAH7

2.78e-041927349cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

CCDC146 ABCA13 CFAP44 DNAH7

2.83e-041937340e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ANO4 ANO1 PLCB1 TACC2

2.83e-04193734000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NINL TACC2 ALDH1L1 DNAH7

2.83e-041937343866667dd221612589ae50f5c52f73a183a49ce6
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

CCDC146 ABCA13 CFAP44 DNAH7

2.83e-04193734a0baa8be6f590b2031fede22be588715ae458e93
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CCDC146 ABCA13 CFAP44 DNAH7

2.89e-04194734756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.89e-041947343cd90d01ed5a5ce65aad8284dab2537ec16e3d7c
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_proliferating-Alveolar_macrophage_proliferating_L.1.0.7.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP8B3 CIP2A SPC25 MCEMP1

2.89e-04194734e5b81a8e52259a54a911c1c2ac932c98c988318d
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.89e-041947344a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ANO4 ANO1 PLCB1 TACC2

2.89e-0419473467f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-04195734649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-04195734d211a836cf711fdb91b10d512f09d462be937cc5
ToppCelldistal-Epithelial-Proximal_Ciliated|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CCDC146 ABCA13 ALDH1L1 DNAH7

2.95e-04195734abe7998421dc59bdae35c0c2251c4a1ebef5e021
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-0419573479dc031258579ea328181dda33710dd897f1064a
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-04195734db4270c135c392ed443670981656e3cd5b95939d
ToppCellNS-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-0419573434e37cff4849696ca4ba5dd8fd2cf98fed8bc912
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-04195734129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-041957343e70ee987d66d450062d5df3d7c733ccc7344470
ToppCelldistal-Epithelial-Proximal_Ciliated-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CCDC146 ABCA13 ALDH1L1 DNAH7

2.95e-041957340e3f74e0877d33c11f048b9be8394596cf5c9c4c
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

CCDC146 CFAP44 DNAH7 DNAH1

2.95e-0419573460067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-041957346365e3893e38231090ec2dbef010dec71dea3d07
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ABCA13 CFAP44 DNAH7

2.95e-041957349651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCellnormal_Pleural_Fluid-B_lymphocytes-MALT_B_cells|B_lymphocytes / Location, Cell class and cell subclass

CALU SPC25 HDLBP IFNAR2

3.01e-041967340ff8cfb209063a8b217df6690ac1dec89004593f
ToppCellmild-Lymphocytic-Prol._cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CIP2A SPC25 MCM7 YWHAE

3.01e-04196734b1d9866d5dfaefdb8bedaf01a750d97987acb3d1
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ATP8B3 CIP2A SPC25 MCM7

3.01e-0419673434bd155e6d848eb53d613997c0e244535de30ba3
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SF3B1 CALU SPAG9 MAPK1

3.01e-04196734151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCellMild/Remission-Plasmablast|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CALU GUSB HDLBP IFNAR2

3.01e-04196734dcf0a804a79a05454658498d1f87320c7e079219
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANO4 CCDC146 CFAP44 DNAH7

3.06e-0419773474a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellSevere-Plasmablast|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ABCC4 CALU HDLBP IFNAR2

3.06e-041977341089aa7991812378668d0f3d57f8000e6245a713
ToppCellILEUM-inflamed-(5)_Plasmablasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TXNL4A SPC25 HDLBP IFNAR2

3.06e-041977348710a586fc91cf664032a12e4d2a0399b370cbcb
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC146 ALDH1L1 CFAP44 DNAH7

3.06e-04197734d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS|TCGA-Stomach / Sample_Type by Project: Shred V9

RIOK1 SPC25 MCM7 YWHAE

3.12e-0419873408f9f05abad4e4078362ea8537c616084cb5d70a
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

CCDC146 CFAP44 DNAH7 DNAH1

3.12e-04198734e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellsevere-Lymphocytic-Prol._cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CIP2A SPC25 MCM7 YWHAE

3.12e-041987344d8591eabb543ed789f963b507a07c560c76a7c9
Diseasenervous system disease (implicated_via_orthology)

SKOR2 KIF1B SKOR1

3.15e-0612733DOID:863 (implicated_via_orthology)
Diseaseplatelet-to-lymphocyte ratio

ABCC4 ATP6V1G3 KIF1B LEMD2 SPC25 DNM3 BRD3 ITGAL

3.25e-06363738EFO_0008446
Diseasecataract 46 juvenile-onset (implicated_via_orthology)

LEMD3 LEMD2

6.04e-062732DOID:0110243 (implicated_via_orthology)
Diseasehepatocellular carcinoma (is_implicated_in)

SF3B1 NF2 KIF1B MCM7 SPAG9

8.81e-05181735DOID:684 (is_implicated_in)
DiseaseKidney Neoplasm

NF2 DNM3 MAPK1

1.34e-0440733C0022665
Diseaseosteoarthritis, spine, body mass index

PER3 SPATA16

1.67e-048732EFO_0004340, EFO_1000787
DiseaseMalignant neoplasm of kidney

NF2 DNM3 MAPK1

1.91e-0445733C0740457
Diseasenephritis (implicated_via_orthology)

PTK2B ITGAL

2.68e-0410732DOID:10952 (implicated_via_orthology)
Diseaseeosinophil count

PTK2B ATP6V1G3 SCAND2P SPC25 SMURF1 ANO1 SIK2 BRD3 DNAH7 HDLBP IFNAR2 RAD50

2.73e-0414887312EFO_0004842
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

LEMD3 LEMD2

3.92e-0412732DOID:11726 (implicated_via_orthology)
Diseasealpha-hydroxybutyric acid measurement

ABCC4 SPC25

3.92e-0412732EFO_0010458
DiseaseWithdrawal Symptoms

PER3 SMURF1 MAPK1

4.07e-0458733C0087169
DiseaseDrug Withdrawal Symptoms

PER3 SMURF1 MAPK1

4.07e-0458733C0086189
DiseaseSubstance Withdrawal Syndrome

PER3 SMURF1 MAPK1

4.07e-0458733C0038587
Diseaseresponse to irinotecan

ABCC4 PLCB1

6.21e-0415732EFO_0004829
Diseasecolorectal cancer

ABCC4 SKOR1 ANO1 PLCB1 BRD3 EIF3H CFAP44

7.37e-04604737MONDO_0005575
DiseaseMalignant neoplasm of breast

CNNM4 PER3 NF2 PIGS STXBP4 PLCB1 ZFYVE26 TACC2 HDLBP

1.30e-031074739C0006142
Diseasecolon adenocarcinoma (is_implicated_in)

PIK3R3 MAPK1

1.89e-0326732DOID:234 (is_implicated_in)
Diseaseaortic root size

ANO1 EIF3H

1.89e-0326732EFO_0005037
Diseaseneutrophil count

ATP6V1G3 GUSB KIF1B PIK3R3 SPC25 DNM3 PLCB1 BRD3 ITGAL YWHAE

2.08e-0313827310EFO_0004833
DiseaseHematopoetic Myelodysplasia

SF3B1 PLCB1

2.35e-0329732C2713368
Diseaseeosinophil percentage of leukocytes

PTK2B ATP6V1G3 ANO1 SIK2 BRD3 IFNAR2 RAD50

2.47e-03746737EFO_0007991

Protein segments in the cluster

PeptideGeneStartEntry
AKEEAMVEIDQYRMQ

ATP6V1G3

36

Q96LB4
MVEIDQYRMQRDKEF

ATP6V1G3

41

Q96LB4
EDKLKMIREYRQMVE

YWHAE

76

P62258
MIREYRQMVETELKL

YWHAE

81

P62258
EVVAMARKLQDVFEM

BRD3

396

Q15059
LMDRVDEMSQDIVKY

EIF3H

246

O15372
MYQKVMEINREVEEL

ANKRD30B

511

Q9BXX2
YVDQIKELVEVMVDM

ADGRA2

476

Q96PE1
EEAMIAYVEEMKKII

ACBD5

111

Q5T8D3
LVYEQEIQIEEYMRM

ABCA13

3591

Q86UQ4
DYMKDIVVQETMEDI

CALU

186

O43852
MELGEERVYQVLAIM

ATP8B3

621

O60423
EMMYEAELERLQKER

ANO4

926

Q32M45
ELEIMKRDEIKHVYM

CFAP44

1351

Q96MT7
MLDEYFEEQMKEIIR

DDX27

376

Q96GQ7
TEEREEEMKQMEVYR

ERC1

416

Q8IUD2
DVTIMERFQMELKDV

RAD50

791

Q92878
QFRDAEEKYREMMIV

RAD50

1096

Q92878
VEMARVLMERNQYKE

SPAG9

506

O60271
EETRQMYDMVVKIID

LEMD3

661

Q9Y2U8
EQMKDVYIVQDLMET

MAPK1

96

P28482
VRYQTEAVEMMDQIV

RENBP

151

P51606
IMKLDIEQYRMVKEA

GPD2

126

P43304
VEMARVLMERNQYKE

MAPK8IP3

526

Q9UPT6
EEENKERAKREMVMY

MFF

311

Q9GZY8
EEEQAMYEMVKKIID

LEMD2

406

Q8NC56
MYEMVKKIIDVVQDH

LEMD2

411

Q8NC56
QEMEKRLQEMEILYK

KIF1B

676

O60333
VFETQERVYMVMELA

PSKH1

161

P11801
SEIDKRVQYMIEVMF

CWC22

326

Q9HCG8
RVQYMIEVMFAVRKD

CWC22

331

Q9HCG8
MVVMEVNSEFIVEVK

DSG4

16

Q86SJ6
DIEYQIREMIMQFIT

DNM3

151

Q9UQ16
VSEELIMVVQEMKKY

PER3

51

P56645
EKVLMVELFMREEQD

ANO1

926

Q5XXA6
KDVLDVYIEHRLMME

MCM7

96

P33993
LEAMDMVEVIYINRK

IFNAR2

296

P48551
RLSMEIEKEKVEYME

NF2

516

P35240
MMISVERVIEYTDLE

ABCC4

1006

O15439
EMAAVMRKAIEIDEQ

FGFR1OP2

181

Q9NVK5
REGNEKEIERIMMNY

PIK3R3

246

Q92569
LEERIVKVMDDYQVM

DNAH1

881

Q9P2D7
EEYQKQMIEEKMERD

CPLX4

46

Q7Z7G2
YAQDLNVIEEVIRMM

DYM

521

Q7RTS9
EVMQMCDRYGIVVID

GUSB

391

P08236
ELMEMKAYIQKVEVT

DNAH7

606

Q8WXX0
EERKEDQYMKMTVCL

BLVRA

191

P53004
MEVEEIYKHQEVKMQ

MCEMP1

1

Q8IX19
EMYIKKLMEIITVEN

GBF1

496

Q92538
DVYQMEKDIAMEQER

PTK2B

681

Q14289
KIIEEEEEINYMKRM

IYD

151

Q6PHW0
VRVEVDMVRVMEVFL

PIGS

376

Q96S52
EVKNYERDMDIIMKL

RIOK1

436

Q9BRS2
QDQMKRELAYREEMV

SKOR1

891

P84550
LEKIYREVQIMKMLD

SIK2

61

Q9H0K1
MDVEMKLVYIDEMGV

SPATA16

121

Q9BXB7
QVVMKVDVVYEKQML

ITGAL

1076

P20701
IETELMMEQVKEHYQ

NINL

616

Q9Y2I6
MEMDYEEVIRLLEAK

STXBP4

366

Q6ZWJ1
EEIFEESYRQIMKMR

SMURF1

406

Q9HCE7
LKEEERMVEMFLEYQ

SPC25

51

Q9HBM1
IDYVEMAVNKRTVRM

ALDH1L1

406

O75891
ITMIEEEMVQLRKRY

CCDC146

616

Q8IYE0
DVRISDIMDVYEMKL

CIP2A

616

Q8TCG1
MERYLRDKTVMIIVA

TRAF3IP2

456

O43734
EIRTVYNREKLMEML

CNNM4

331

Q6P4Q7
AEQYRKMVMETIEKI

SF3B1

861

O75533
MLVESQGEMIDRIEY

STX1A

221

Q16623
QDEDMLRYMINLEVE

TSPYL4

271

Q9UJ04
RVMYVMLIIQMETED

SCAND2P

291

Q9GZW5
RREVMEMRKIVAEYE

TACC2

2776

O95359
MEEEKTEMIRSYIQE

PLCB1

1091

Q9NQ66
QDQMKRELAYREEMV

SKOR2

976

Q2VWA4
GMVKDLINRMDYVEI

HDLBP

426

Q00341
MEDKQEMVDIIETVY

TXNL4A

106

P83876
VEMLQDVIDVMKRSE

TRIM22

246

Q8IYM9
VVDLLVEVMDIIMYC

WDR7

1321

Q9Y4E6
ELMFMERYQEVIQEL

ZFYVE26

866

Q68DK2
EMEMVIQQYEKAKVI

TMEM266

226

Q2M3C6