Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessintrahepatic bile duct development

GAK NOTCH2

2.54e-054432GO:0035622
DomainDMAP_binding

DIP2C DIP2A

4.68e-055412PF06464
DomainDMAP1-bd

DIP2C DIP2A

7.01e-056412IPR010506
DomainDMAP_binding

DIP2C DIP2A

7.01e-056412SM01137
DomainPPASE_TENSIN

GAK TNS4

1.68e-049412PS51181
Domain-

AKAP13 TNS4 PLCH1 RANBP3L PHLDB2

1.58e-033914152.30.29.30
DomainAMP-binding

DIP2C DIP2A

1.97e-0330412PF00501
DomainAMP-dep_Synth/Lig

DIP2C DIP2A

1.97e-0330412IPR000873
DomainPH_dom-like

AKAP13 TNS4 PLCH1 RANBP3L PHLDB2

2.30e-03426415IPR011993
Pubmed

Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.

DIP2C DIP2A

1.49e-06243212137943
Pubmed

Identification of rare missense mutations in NOTCH2 and HERC2 associated with familial central precocious puberty via whole-exome sequencing.

HERC2 NOTCH2

1.49e-06243232400230
Pubmed

CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.

DIP2C DIP2A

4.48e-06343217236128
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DIP2C ADGRL1 DIP2A AKAP13 HERC2 ARID3A TMEM94 NOTCH2 SORBS3

6.81e-06110543935748872
Pubmed

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.

RELN NOTCH2

2.23e-05643218957219
Pubmed

Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins.

EVI5 ERBB3

5.35e-0594329070650
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

COL18A1 DIP2A AKAP13 GAK HERC2 PLCH1 SRRM2 SLC33A1 NOTCH2

7.05e-05148743933957083
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

BCL9L AKAP13 ERBB3 SRRM2 PHLDB2

8.16e-0536143526167880
Pubmed

Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding.

RELN NOTCH2

9.78e-051243210952903
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ADGRL1 PLCH1 TMEM94 NOTCH2 PHLDB2

1.67e-0442143536976175
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

COL18A1 PAN3 PITRM1 SLC33A1 NOTCH2 KNOP1 SORBS3

2.17e-04100743734597346
Pubmed

Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.

COL18A1 NOTCH2

2.26e-041843214607778
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

TRMT6 HERC2 NHSL2 TMEM94 SLC33A1 NOTCH2

2.43e-0471943635337019
Pubmed

Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.

CELF4 TTC21A

2.52e-041943224564958
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

DIP2A AKAP13 TRMT6 MYO15B RANBP3L TTC21A

2.75e-0473643629676528
Pubmed

An Alternative Splicing Program for Mouse Craniofacial Development.

EVI5 MTA1

3.09e-042143233013468
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

AKAP13 MTA1 SRRM2 PHLDB2 SORBS3

3.80e-0450343516964243
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DIP2C ADGRL1 COL18A1 AKAP13 PAN3 TTC21A NOTCH2 FAM149A

4.21e-04148943828611215
Pubmed

Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.

RELN NOTCH2

4.40e-042543235815610
Pubmed

Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.

DIP2C DIP2A

5.53e-042843231600191
Pubmed

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.

ERBB3 RELN

5.93e-042943226633882
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

AKAP13 PAN3 PLCH1 SRRM2 NOTCH2 PHLDB2

6.31e-0486143636931259
Pubmed

Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.

RELN NOTCH2

6.35e-043043219054571
Pubmed

Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.

ERBB3 NOTCH2

7.69e-043343220203524
Pubmed

Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.

RELN CELF4

8.66e-043543237758766
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

MTA1 SORBS3

8.66e-043543219389355
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

TRMT6 MTA1 HERC2 ARID3A KNOP1

8.93e-0460843536089195
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

COL18A1 MTA1 SRRM2 KNOP1

9.03e-0434943425665578
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DIP2A NCKAP5 ERBB3 RELN MTA1 HERC2 ASPA

9.30e-04128543735914814
Pubmed

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

NCKAP5 RELN

1.07e-033943219010793
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

COL18A1 MYO15B HERC2 SRRM2 PHLDB2

1.11e-0363943523443559
Pubmed

Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

DIP2A TMEM94

1.19e-03414328724849
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DIP2A AKAP13 ERBB3 PLCH1 SLC33A1

1.20e-0365043538777146
Cytoband3q25.31

PLCH1 SLC33A1

1.36e-04184423q25.31
Cytoband17q25.1

MYO15B TMEM94

2.77e-038144217q25.1
CytobandEnsembl 112 genes in cytogenetic band chr10p15

DIP2C PITRM1

3.41e-0390442chr10p15
CytobandEnsembl 112 genes in cytogenetic band chr18q12

CELF4 ZSCAN30

4.52e-03104442chr18q12
GeneFamilySH2 domain containing

TNS4 INPP5D

6.05e-03101212741
CoexpressionLAIHO_COLORECTAL_CANCER_SERRATED_DN

ERBB3 MTA1 SRRM2 INPP5D

1.15e-0585434M17423
CoexpressionGSE37301_LYMPHOID_PRIMED_MPP_VS_CD4_TCELL_DN

COL18A1 HERC2 TMEM94 SLC33A1 NOTCH2

1.78e-05198435M8859
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL18A1 NCKAP5 ERBB3 MYO15B ASPA

1.09e-06186445d57c40b3fe5cfc87e771df76533d9a3e94678b04
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B RANBP3L NOTCH2

1.21e-061904452de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B RANBP3L NOTCH2

1.24e-06191445f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

EVI5 AKAP13 INPP5D NOTCH2

1.97e-05162444810881210e015c788814e4fe8d7a24c929cf2621
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1QC CELF4 TNS4 INPP5D

2.01e-051634447af3d3ae7e0de733a18d0486c7ffbb5a7ef7230a
ToppCellfacs-Pancreas-Endocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC TNS4 C1orf162 INPP5D

2.32e-05169444c68a305069a149d66dfdeef2a8010f460dc1da3b
ToppCellfacs-Pancreas-Endocrine-18m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC TNS4 C1orf162 INPP5D

2.32e-051694440e3d0b71fc21fd1de7034d13895608de5494fad8
ToppCellfacs-Pancreas-Endocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC TNS4 C1orf162 INPP5D

2.32e-0516944480089dfb1f0f4d6bdf6ca161e902b38011992dfd
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

NUGGC AKAP13 TMEM200A ASPA

2.43e-05171444bdd30100b74e012eec3090799c22635aa57fa91d
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NUGGC AKAP13 TMEM200A ASPA

2.60e-0517444499d7421ad5eafe7751ef90698a92f683aa33bca8
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL18A1 ERBB3 RELN ASPA

2.97e-05180444dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL18A1 ERBB3 RELN ASPA

2.97e-05180444d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL18A1 ERBB3 RELN PLCH1

2.97e-05180444b294f9db1e2ff51c94cde64fae4c2b057c0030a1
ToppCellMesenchymal_cells-Stromal_fibro.|Mesenchymal_cells / Lineage and Cell class

COL18A1 RELN TTC21A ASPA

3.03e-05181444f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

COL18A1 NCKAP5 ERBB3 PHLDB2

3.17e-051834446821dca076318115d360ff426eb1218cfe104063
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.23e-05184444a2191dd5546efd357b23e625beb3c5820476f243
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.30e-05185444b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.44e-0518744497e520705491c8f52a32025311a9fa7b9176979a
ToppCell5'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1QC NCKAP5 C1orf162 INPP5D

3.52e-05188444ecbba19eebba21b986caa99de78ea4245fde3600
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.52e-05188444505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCell5'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C1QC NCKAP5 C1orf162 INPP5D

3.52e-0518844472a1ee136d77c77e44793a512f60b5f7815a073a
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.59e-0518944442ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.59e-05189444784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

DIP2C AKAP13 NCKAP5 PHLDB2

3.59e-051894440a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.59e-0518944437ecbd73408d462b47d7e5611f203143e08a2689
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.67e-0519044407f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

DIP2C AKAP13 NCKAP5 PHLDB2

3.67e-0519044493c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL18A1 NCKAP5 ERBB3 ASPA

3.67e-051904446b101359f397020a21e2bfd15851cb48e71f4502
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL18A1 NCKAP5 ERBB3 ASPA

3.67e-05190444396b7225c2430db3dc55a3d0db70239b71987229
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.67e-05190444ae97df1b06bcd46c05759b53c35dc8fea97f4ac1
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.74e-051914442110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NCKAP5 ERBB3 MYO15B ASPA

3.74e-051914442b056cbe2e82e056e1f798974999378460eb1d16
ToppCell(7)_Epithelial_cells-(7)_Epithelial-H_(AT1)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

COL18A1 TNS4 INPP5D ASPA

3.82e-051924447a6dd2ae217b8f8e460d47ad128904408299458c
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

DIP2C AKAP13 NCKAP5 PAN3

3.82e-05192444e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellfacs-Heart-RA-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP13 PAN3 NOTCH2 SORBS3

4.22e-05197444940cf1e54d7c820e04946258a8b784f35c6a144c
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL18A1 NCKAP5 PHLDB2 SORBS3

4.30e-05198444b7e900fc0a1b3fa5e47dcc36ce6b0c3ce6bf9739
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C1QC AKAP13 C1orf162 SRRM2

4.39e-05199444667b8b47a5b388506e3177b46747267fad8024f6
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C1QC TRMT6 C1orf162 NHSL2

4.39e-051994448fcb32eee0ec0dd88209e723a6f82f425c73ca40
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2|Neuronal / cells hierarchy compared to all cells using T-Statistic

NUGGC ERBB3 RELN PLCH1

4.48e-05200444858421b91f5207b7934b5c219752cb9322a3da31
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

C1QC AKAP13 NCKAP5 INPP5D

4.48e-0520044421bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellMacroglial|World / cells hierarchy compared to all cells using T-Statistic

NCKAP5 ERBB3 MYO15B ASPA

4.48e-05200444e6935ad49216d2500c15c05cbc2b89402c65e838
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

C1QC AKAP13 NCKAP5 INPP5D

4.48e-05200444a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellTracheal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL18A1 NCKAP5 NHSL2 PHLDB2

4.48e-052004449d3ae9ea47b1017adb63aa02d10e98193d478458
ToppCellTracheal-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL18A1 NCKAP5 NHSL2 PHLDB2

4.48e-0520044478cd0b7d221ef855512ee9ac9a291f61622c2e24
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

C1QC AKAP13 NCKAP5 INPP5D

4.48e-05200444dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

C1QC AKAP13 NCKAP5 INPP5D

4.48e-05200444a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

C1QC AKAP13 NCKAP5 INPP5D

4.48e-052004443bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

C1QC AKAP13 NCKAP5 INPP5D

4.48e-0520044433036d21c1c82109284473a515c4f890b33fdd5c
ToppCellSigmoid-T_cell-Tfh|T_cell / Region, Cell class and subclass

C1QC ADGRL1 COL18A1 TMEM200A

4.48e-05200444dd7dcf25520f065bf0d33d589f3c176f63875dc9
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

NUGGC ERBB3 RELN PLCH1

4.48e-05200444a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

NUGGC ERBB3 RELN PLCH1

4.48e-052004442131c8e7fa054b79906eaf60536da892438b09cd
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Rassf10|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NCKAP5 ERBB3 SORBS3

2.21e-04119443ec3af1253f03b3ec403f73243237acf08ad56789
ToppCellEndothelial-G|World / shred on cell class and cell subclass (v4)

COL18A1 RELN MYO15B

2.49e-041244434b72809463f2986b7d1b7ab9de633ac4d7854a92
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB3 ASPA SORBS3

3.34e-04137443ca8fdbe66a854e6283b22179ec9359ea9e86cd8e
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB3 ASPA SORBS3

3.48e-04139443789edd3c98e7c5c1cc402c780fded9a9dfd1dfb8
ToppCellASK440-Epithelial-Secretory|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

C1QC COL18A1 INPP5D

3.71e-04142443ea694a907eaa46c55665692cb830870281700e40
ToppCellCOVID-19_Moderate-B_cell|COVID-19_Moderate / disease group, cell group and cell class

COL18A1 ERBB3 CELF4

3.71e-0414244388bb8d9bca66131df4ee7021b88248e146aa7aa6
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DIP2C NUGGC PLCH1

3.78e-041434437a7a9829ba63468c9745904d9e993590051207ab
ToppCellfacs-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C1QC CELF4 TNS4

4.02e-0414644326493014daa432db721613ef480d133f3da9eb58
ToppCellCOVID-19_Moderate-multiplets|COVID-19_Moderate / disease group, cell group and cell class

FNDC4 DIP2A NCKAP5

4.10e-04147443baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB3 ASPA SORBS3

4.18e-04148443d60f93311cfa718d026a0dbf61771bbbcbb79146
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB3 ASPA SORBS3

4.18e-0414844344128692824ca419fface0af41099c17135933ce
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB3 ASPA SORBS3

4.35e-04150443b30f52b94ce772632a1f2f5e0837db876cf92651
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB3 ASPA SORBS3

4.35e-0415044305b9a9cbc5a95cdaf45d5f173e132acd4da9aa8a
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NCKAP5 ERBB3 TRMT6

4.35e-0415044370ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCellHippocampus-Hematopoietic|Hippocampus / BrainAtlas - Mouse McCarroll V32

C1QC C1orf162 INPP5D

4.44e-0415144381b2189afd72658f7e2539b856ba79cd49340215
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL18A1 ERBB3 RANBP3L

4.52e-04152443c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCellStriatum-Hematopoietic|Striatum / BrainAtlas - Mouse McCarroll V32

C1QC C1orf162 INPP5D

4.79e-0415544312301d823338bf829475905c66c5f08f7159d29f
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd|lymph-node_spleen / Manually curated celltypes from each tissue

ADGRL1 ZSCAN30 SLC33A1

4.79e-04155443b0e456c4915076e1d38282e116a6eb3230ae80dc
ToppCellPND07-28-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative|PND07-28-samps / Age Group, Lineage, Cell class and subclass

C1orf162 ARID3A NOTCH2

4.88e-04156443166f7b1220eaf8e1149dde260dd85a094855c54f
ToppCellPND07-28-samps-Myeloid-Granulocyte|PND07-28-samps / Age Group, Lineage, Cell class and subclass

C1orf162 ARID3A NOTCH2

4.88e-041564435e1c5a7c9293b886920739cf766521df7f69726c
ToppCellBAL-Severe-cDC_4|Severe / Compartment, Disease Groups and Clusters

EVI5 DIP2C NHSL2

5.06e-0415844373f66689ef59f71b14cb7141ca5951cc47fe57c1
ToppCellfacs-Lung-EPCAM-3m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELF4 C1orf162 NOTCH2

5.06e-04158443ef5feb48161c339c7b71c576bdda61479d29dfac
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CELF4 C1orf162 NOTCH2

5.06e-04158443c6e64b9b3342e37d54baadae8fb7dfb5d246e4cf
ToppCelldroplet-Kidney-nan-3m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC CELF4 TNS4

5.16e-04159443bea6e96ba40ebfc1e38687bfa1c61fe227c5a84d
ToppCellSubstantia_nigra-Hematopoietic|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

C1QC C1orf162 INPP5D

5.25e-0416044319d71d02f06f34eff37d268a78e5eed34da4ca44
ToppCellfacs-Pancreas-Endocrine-24m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.35e-041614435680939068b5a63aa1064202b4ee8847156c8ccd
ToppCellfacs-Pancreas-Endocrine-24m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.35e-041614437a19f3c652534e93a15c0a9692a67397a70d6ad4
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1QC TNS4 INPP5D

5.35e-041614438937f6b92cb2a93ea8c4780d9200a518c3112e53
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RELN TNS4 ASPA

5.35e-04161443da9eecf919866a9c579d7a707a996cf335213134
ToppCellfacs-Pancreas-Endocrine-24m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.35e-04161443e713f4165b8deb98652cab59bfdd53df41a5d177
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RELN TNS4 ASPA

5.35e-04161443d431625c32f59a6b552191f3adc5198bd16ad5cf
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EVI5 C1QC COL18A1

5.45e-0416244314e9f8aaba308619eb9da90796c336e76cedac1f
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EVI5 C1QC COL18A1

5.45e-04162443860ebf2390b4ad86475ad54717cbefcf61cd3b2a
ToppCelldroplet-Pancreas-Endocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.54e-04163443aaff80d254131d1f1230bb12b6f43bc061ab5ab3
ToppCelldroplet-Pancreas-Endocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.54e-041634438b0f8a2d5b38f3bbff265211a7607acc85fa38b0
ToppCelldroplet-Pancreas-Endocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.54e-04163443644c8a8af6a378fced4c70dec9a0de906f8d6e69
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NUGGC RELN ARID3A

5.64e-04164443b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NUGGC RELN ARID3A

5.64e-04164443a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCellfacs-Pancreas-Endocrine-3m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.74e-041654432e9e703c3f89784a47ed40f799d2aa86eba6cc9a
ToppCellfacs-Pancreas-Endocrine-3m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.74e-041654434d51eb992670bce164eea29b540877b4d567953c
ToppCelldroplet-Thymus-nan-21m-Myeloid-Plasma_cells_and_B_cells|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NUGGC RELN ARID3A

5.74e-0416544321a82a975f550080b6674750b06212205cd16742
ToppCellfacs-Pancreas-Endocrine-3m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QC C1orf162 INPP5D

5.74e-041654438715ea74d02e9b7cd05fa1b4896b353078544678
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

ERBB3 RELN ASPA

5.74e-041654436ed52cb756d21addf46c7f6c457458b01339fe04
ToppCellDendritic_Cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

C1QC C1orf162 INPP5D

5.85e-04166443fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4-5_RORB_AIM2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL18A1 RELN PHLDB2

5.95e-041674434c8bb68ee2bf7b794940b34df96f38f3f69507e9
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|356C / Donor, Lineage, Cell class and subclass (all cells)

NUGGC AKAP13 TMEM200A

6.05e-041684439d6ca10c272aea28082c09d469940f7232f6461c
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

ERBB3 RELN ASPA

6.05e-041684432fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

ERBB3 RELN ASPA

6.05e-04168443c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellDendritic_Cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

C1QC C1orf162 INPP5D

6.05e-0416844333618e5dbcee31f30afacacc9f6046782c100fb3
Diseaseatopic eczema

EVI5 NCKAP5 ERBB3 PGLYRP4 INPP5D

2.87e-05252425EFO_0000274
Diseaseage at onset, multiple sclerosis

NCKAP5 RELN

8.84e-0510422EFO_0004847, MONDO_0005301
DiseaseBenign neoplasm of bladder

ERBB3 NOTCH2

2.05e-0415422C0154017
DiseaseNeoplasm of uncertain or unknown behavior of bladder

ERBB3 NOTCH2

2.05e-0415422C0496930
DiseaseCarcinoma in situ of bladder

ERBB3 NOTCH2

2.05e-0415422C0154091
DiseaseCarcinoma of bladder

ERBB3 NOTCH2

2.98e-0418422C0699885
Diseaseintestinal cancer (implicated_via_orthology)

ERBB3 NOTCH2

9.55e-0432422DOID:10155 (implicated_via_orthology)
Diseasecataract

DIP2A HERC2 SLC33A1

1.07e-03141423MONDO_0005129
DiseaseCataract

COL18A1 SLC33A1

1.28e-0337422C0086543
DiseaseBreast adenocarcinoma

HERC2 NOTCH2

1.57e-0341422C0858252
DiseaseNeoplasm of uncertain or unknown behavior of breast

HERC2 NOTCH2

1.57e-0341422C0496956
Diseaseage at assessment, pelvic organ prolapse

NCKAP5 RANBP3L

1.72e-0343422EFO_0004710, EFO_0008007
Diseasealcohol use disorder (implicated_via_orthology)

ERBB3 SRRM2 NOTCH2

2.70e-03195423DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PGNFSHSLDMKSGPL

SLC33A1

16

O00400
MPDTHLKGTPSSREG

ERBB3

1161

P21860
SPPGGTHGSLKTSAM

ADGRL1

1121

O94910
CHMSLSSPELGPLTK

AKAP13

1276

Q12802
GPNRSFLSLKHTPMG

NOTCH2

2086

Q04721
GSLLMPGHEASSKDP

NGRN

171

Q9NPE2
GTKLPTGVDHMASPL

FAM149A

636

A5PLN7
SEGDMHLLSGPLSPN

HERC2

356

O95714
MFHTLDKSPLAPGSS

FNDC9

91

Q8TBE3
KKGHSPSPAALSAME

PGLYRP4

156

Q96LB8
PLVMGSLGKHAAPSA

COL18A1

266

P39060
GFPLHGKSGSMSLDP

EVI5

756

O60447
EGDALPGHSKPSRSM

KNOP1

221

Q1ED39
LLHPGGTKMPVCGST

RELN

2336

P78509
LAKLGINGAHSSPPM

MYO15B

1126

Q96JP2
LAPGMSLSAGSSPLH

PAN3

331

Q58A45
MDVGPSSLPHLGLKL

C1QC

1

P02747
FLHLGDLPGEPSKMT

GAK

1011

O14976
HSSPPSGLRGDMASL

FNDC4

6

Q9H6D8
SPGMGHLKSPTLSQV

BCL9L

926

Q86UU0
GSPHSLPLMESGKIL

DIP2C

1336

Q9Y2E4
GSPHSLPLMESGKIL

DIP2A

1351

Q14689
LLSGTMADHSKPQAP

C1orf162

86

Q8NEQ5
TGKPTGSALMPHIDA

NUGGC

591

Q68CJ6
RHSLSGSSPGMKDIP

SRRM2

1456

Q9UQ35
GKSSGHLMPPLLSDS

TMEM200A

236

Q86VY9
SSSKPHLKPALGMNG

NCKAP5

1256

O14513
HMPERPSKIGLLTSG

NHSL2

466

Q5HYW2
LKTGGMSASPHVLPD

PITRM1

641

Q5JRX3
SGPKTLKSLTSHDPM

INPP5D

876

Q92835
HGLPARSSGSPKFAM

MTA1

451

Q13330
TMGRSITPKAHLPLG

PHLDB2

916

Q86SQ0
HPGDPMFLTLDGKTI

ASPA

256

P45381
AHGMLSSPKLPVSSL

ARID3A

366

Q99856
LSHSPGNPSTIPMKD

CELF4

36

Q9BZC1
SAAMISPGKLPGETH

ZSCAN30

206

Q86W11
SISLLGKPPHSSIMS

TMEM94

1136

Q12767
MGSKASSPHGLGSPL

TNS4

236

Q8IZW8
MTTIPRKGSSHLPGS

RANBP3L

1

Q86VV4
SPSPHSALALSCKMG

TMDD1

291

P0DPE3
RSLSPHKMADGGSPF

SORBS3

336

O60504
PGPHTSLLLGDALMS

TTC21A

726

Q8NDW8
SVMSGHCPLPSLGLK

PLCH1

1221

Q4KWH8
LPDRSHPKLLMSGGG

TRMT6

436

Q9UJA5
LGKDHLPSSPGLLMV

nan

176

A8MV72
LGKDHLPSSPGLLMV

nan

206

A8MUI8
GKDHLPSSPGLLMVG

nan

206

A6NL46