Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	STK16 EPHB4 CDK16 SLK CDC42BPA SAMD8 MTOR PDIK1L GRK7 POLE DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 PI4KAP2 TSSK3 NME4 GK5 EPHA1 CDK4 EPHB1	1.54e-12	938	81	23	GO:0016772
GeneOntologyMolecularFunction	kinase activity	STK16 EPHB4 CDK16 SLK CDC42BPA MTOR PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 PI4KAP2 TSSK3 NME4 GK5 EPHA1 CDK4 EPHB1	2.06e-12	764	81	21	GO:0016301
GeneOntologyMolecularFunction	protein kinase activity	STK16 EPHB4 CDK16 SLK CDC42BPA MTOR PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 EPHA1 CDK4 EPHB1	2.43e-11	600	81	18	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	STK16 EPHB4 CDK16 SLK CDC42BPA MTOR PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 GK5 EPHA1 CDK4 EPHB1	4.32e-11	709	81	19	GO:0016773
GeneOntologyMolecularFunction	protein serine kinase activity	STK16 CDK16 SLK CDC42BPA MTOR PDIK1L DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 CDK4	2.03e-10	363	81	14	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	STK16 CDK16 SLK CDC42BPA MTOR PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 CDK4	2.88e-10	446	81	15	GO:0004674
GeneOntologyMolecularFunction	glucan 1,4-alpha-glucosidase activity	MGAM MGAM2	1.63e-05	2	81	2	GO:0004339
GeneOntologyMolecularFunction	ephrin receptor activity	EPHB4 EPHA1 EPHB1	5.95e-05	19	81	3	GO:0005003
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	MGAM MGAM2	1.61e-04	5	81	2	GO:0004558
GeneOntologyMolecularFunction	acylglycerol O-acyltransferase activity	GPAT3 AWAT2 DGAT2L6	2.93e-04	32	81	3	GO:0016411
GeneOntologyMolecularFunction	protein tyrosine kinase activity	STK16 EPHB4 DYRK1A EPHA1 EPHB1	3.10e-04	145	81	5	GO:0004713
GeneOntologyMolecularFunction	alpha-glucosidase activity	MGAM MGAM2	3.37e-04	7	81	2	GO:0090599
GeneOntologyMolecularFunction	diacylglycerol O-acyltransferase activity	AWAT2 DGAT2L6	4.48e-04	8	81	2	GO:0004144
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	MAP3K9 MAP3K10	1.04e-03	12	81	2	GO:0004706
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHA1 EPHB1	1.65e-03	15	81	2	GO:0005005
GeneOntologyMolecularFunction	glucosidase activity	MGAM MGAM2	1.65e-03	15	81	2	GO:0015926
GeneOntologyMolecularFunction	O-acyltransferase activity	GPAT3 AWAT2 DGAT2L6	1.78e-03	59	81	3	GO:0008374
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHB4 EPHA1 EPHB1	2.34e-03	65	81	3	GO:0004714
GeneOntologyBiologicalProcess	protein autophosphorylation	STK16 EPHB4 SLK MTOR GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 EPHA1 EPHB1	4.28e-12	228	80	13	GO:0046777
GeneOntologyBiologicalProcess	peptidyl-threonine modification	GALNTL6 CDC42BPA MTOR DYRK1A MAP3K10 STK39 OXSR1	5.58e-07	125	80	7	GO:0018210
GeneOntologyBiologicalProcess	peptidyl-threonine phosphorylation	CDC42BPA MTOR DYRK1A MAP3K10 STK39 OXSR1	5.66e-06	115	80	6	GO:0018107
GeneOntologyBiologicalProcess	acylglycerol metabolic process	ABHD2 GPAT3 GK5 AWAT2 DGAT2L6 PLCE1	3.22e-05	156	80	6	GO:0006639
GeneOntologyBiologicalProcess	neutral lipid metabolic process	ABHD2 GPAT3 GK5 AWAT2 DGAT2L6 PLCE1	3.46e-05	158	80	6	GO:0006638
GeneOntologyBiologicalProcess	acylglycerol acyl-chain remodeling	AWAT2 DGAT2L6	8.87e-05	4	80	2	GO:0036155
GeneOntologyBiologicalProcess	neutral lipid biosynthetic process	GPAT3 AWAT2 DGAT2L6 PLCE1	1.05e-04	63	80	4	GO:0046460
GeneOntologyBiologicalProcess	acylglycerol biosynthetic process	GPAT3 AWAT2 DGAT2L6 PLCE1	1.05e-04	63	80	4	GO:0046463
GeneOntologyBiologicalProcess	peptidyl-tryptophan modification	DPY19L3 DPY19L2	2.21e-04	6	80	2	GO:0018211
GeneOntologyBiologicalProcess	protein C-linked glycosylation via tryptophan	DPY19L3 DPY19L2	2.21e-04	6	80	2	GO:0018317
GeneOntologyBiologicalProcess	protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan	DPY19L3 DPY19L2	2.21e-04	6	80	2	GO:0018406
GeneOntologyBiologicalProcess	protein C-linked glycosylation	DPY19L3 DPY19L2	2.21e-04	6	80	2	GO:0018103
GeneOntologyBiologicalProcess	glycerolipid metabolic process	IMPA1 ABHD2 GPAT3 PI4KAP2 GK5 AWAT2 DGAT2L6 PLCE1	2.57e-04	429	80	8	GO:0046486
GeneOntologyBiologicalProcess	chemokine (C-X-C motif) ligand 12 signaling pathway	STK39 OXSR1	3.08e-04	7	80	2	GO:0038146
GeneOntologyBiologicalProcess	SRP-dependent cotranslational protein targeting to membrane, translocation	SEC61A2 SEC61A1	4.10e-04	8	80	2	GO:0006616
GeneOntologyBiologicalProcess	maintenance of lens transparency	STK39 VPS13B	4.10e-04	8	80	2	GO:0036438
GeneOntologyBiologicalProcess	post-translational protein targeting to membrane, translocation	SEC61A2 SEC61A1	4.10e-04	8	80	2	GO:0031204
GeneOntologyCellularComponent	Sec61 translocon complex	SEC61A2 SEC61A1	1.36e-04	5	78	2	GO:0005784
GeneOntologyCellularComponent	translocon complex	SEC61A2 SEC61A1	2.04e-04	6	78	2	GO:0071256
MousePheno	increased circulating methylmalonic acid level	HCFC1 MMUT	5.98e-05	3	63	2	MP:0030630
MousePheno	abnormal methylmalonic acid level	HCFC1 MMUT	5.98e-05	3	63	2	MP:0030627
MousePheno	increased methylmalonic acid level	HCFC1 MMUT	5.98e-05	3	63	2	MP:0030628
Domain	Protein_kinase_ATP_BS	EPHB4 CDK16 SLK CDC42BPA PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 EPHA1 CDK4 EPHB1	4.07e-12	379	79	16	IPR017441
Domain	PROTEIN_KINASE_ATP	STK16 EPHB4 CDK16 SLK CDC42BPA PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 EPHA1 CDK4 EPHB1	6.39e-12	459	79	17	PS00107
Domain	Kinase-like_dom	STK16 EPHB4 CDK16 SLK CDC42BPA MTOR PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 EPHA1 CDK4 EPHB1	8.59e-12	542	79	18	IPR011009
Domain	Prot_kinase_dom	STK16 EPHB4 CDK16 SLK CDC42BPA PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 EPHA1 CDK4 EPHB1	1.73e-11	489	79	17	IPR000719
Domain	PROTEIN_KINASE_DOM	STK16 EPHB4 CDK16 SLK CDC42BPA PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 EPHA1 CDK4 EPHB1	1.97e-11	493	79	17	PS50011
Domain	Ser/Thr_kinase_AS	STK16 CDK16 SLK CDC42BPA PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 CDK4	2.73e-10	357	79	14	IPR008271
Domain	S_TKc	STK16 CDK16 SLK CDC42BPA PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 CDK4	2.94e-10	359	79	14	SM00220
Domain	PROTEIN_KINASE_ST	STK16 CDK16 SLK CDC42BPA PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 CDK4	3.27e-10	362	79	14	PS00108
Domain	Pkinase	STK16 CDK16 SLK CDC42BPA PDIK1L GRK7 DYRK1A MAP3K9 MAP3K10 IRAK1 STK39 OXSR1 TSSK3 CDK4	6.37e-10	381	79	14	PF00069
Domain	Plug_translocon	SEC61A2 SEC61A1	1.77e-05	2	79	2	PF10559
Domain	SecY_su_dom	SEC61A2 SEC61A1	1.77e-05	2	79	2	IPR023201
Domain	SecY	SEC61A2 SEC61A1	1.77e-05	2	79	2	PF00344
Domain	SECY_1	SEC61A2 SEC61A1	1.77e-05	2	79	2	PS00755
Domain	SECY_2	SEC61A2 SEC61A1	1.77e-05	2	79	2	PS00756
Domain	-	SEC61A2 SEC61A1	1.77e-05	2	79	2	1.10.3370.10
Domain	Translocon_Sec61/SecY_plug_dom	SEC61A2 SEC61A1	1.77e-05	2	79	2	IPR019561
Domain	SecY_CS	SEC61A2 SEC61A1	1.77e-05	2	79	2	IPR030659
Domain	SecY/SEC61-alpha	SEC61A2 SEC61A1	1.77e-05	2	79	2	IPR002208
Domain	RECEPTOR_TYR_KIN_V_2	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	PS00790
Domain	Eph_TM	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	IPR001426
Domain	EPH_lbd	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	SM00615
Domain	Ephrin_lbd	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	PF01404
Domain	EphA2_TM	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	IPR001090
Domain	EPH_LBD	EPHB4 EPHA1 EPHB1	2.56e-05	14	79	3	PS51550
Domain	Dpy19	DPY19L3 DPY19L2	1.05e-04	4	79	2	PF10034
Domain	NtCtMGAM_N	MGAM MGAM2	1.05e-04	4	79	2	PF16863
Domain	MLK1/MLK2/MLK4	MAP3K9 MAP3K10	1.05e-04	4	79	2	IPR016231
Domain	Gal_mutarotase_N	MGAM MGAM2	1.05e-04	4	79	2	IPR031727
Domain	Dpy-19/Dpy-19-like	DPY19L3 DPY19L2	1.05e-04	4	79	2	IPR018732
Domain	MAP3K10	MAP3K9 MAP3K10	1.05e-04	4	79	2	IPR015785
Domain	Ephrin_rec_like	EPHB4 EPHA1 EPHB1	1.57e-04	25	79	3	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB4 EPHA1 EPHB1	1.57e-04	25	79	3	IPR011641
Domain	SAM_1	EPHB4 SAMD8 EPHA1 EPHB1	1.97e-04	68	79	4	PF00536
Domain	Kinase_OSR1/WNK_CCT	STK39 OXSR1	2.62e-04	6	79	2	IPR024678
Domain	OSR1_C	STK39 OXSR1	2.62e-04	6	79	2	PF12202
Domain	Glyco_hydro_31_AS	MGAM MGAM2	2.62e-04	6	79	2	IPR030458
Domain	Ser-Thr/Tyr_kinase_cat_dom	EPHB4 MAP3K9 MAP3K10 EPHA1 EPHB1	2.98e-04	138	79	5	IPR001245
Domain	Glyco_hydro_31	MGAM MGAM2	3.66e-04	7	79	2	IPR000322
Domain	DAGAT	AWAT2 DGAT2L6	3.66e-04	7	79	2	PF03982
Domain	DAGAT	AWAT2 DGAT2L6	3.66e-04	7	79	2	IPR007130
Domain	Glyco_hydro_31	MGAM MGAM2	3.66e-04	7	79	2	PF01055
Domain	GLYCOSYL_HYDROL_F31_1	MGAM MGAM2	3.66e-04	7	79	2	PS00129
Domain	Trefoil	MGAM MGAM2	4.87e-04	8	79	2	PF00088
Domain	TyrKc	EPHB4 MAP3K9 EPHA1 EPHB1	5.28e-04	88	79	4	SM00219
Domain	SAM	EPHB4 SAMD8 EPHA1 EPHB1	5.28e-04	88	79	4	SM00454
Domain	Tyr_kinase_cat_dom	EPHB4 MAP3K9 EPHA1 EPHB1	5.28e-04	88	79	4	IPR020635
Domain	P_TREFOIL_2	MGAM MGAM2	6.24e-04	9	79	2	PS51448
Domain	PD	MGAM MGAM2	6.24e-04	9	79	2	SM00018
Domain	SAM_DOMAIN	EPHB4 SAMD8 EPHA1 EPHB1	7.05e-04	95	79	4	PS50105
Domain	SAM	EPHB4 SAMD8 EPHA1 EPHB1	7.62e-04	97	79	4	IPR001660
Domain	-	MGAM MGAM2	9.48e-04	11	79	2	4.10.110.10
Domain	-	EPHB4 SAMD8 EPHA1 EPHB1	1.06e-03	106	79	4	1.10.150.50
Domain	P_trefoil_dom	MGAM MGAM2	1.13e-03	12	79	2	IPR000519
Domain	SAM/pointed	EPHB4 SAMD8 EPHA1 EPHB1	1.53e-03	117	79	4	IPR013761
Domain	Gal_Oxase/kelch_b-propeller	KBTBD2 KLHL18 HCFC1	2.00e-03	59	79	3	IPR011043
Domain	Pkinase_Tyr	EPHB4 MAP3K10 EPHA1 EPHB1	2.19e-03	129	79	4	PF07714
Domain	Gal_mutarotase_SF_dom	MGAM MGAM2	2.31e-03	17	79	2	IPR011013
Domain	BTB	RHOBTB1 RHOBTB2 KBTBD2 KLHL18	2.31e-03	131	79	4	PF00651
Domain	RHO	RHOBTB1 RHOBTB2	3.19e-03	20	79	2	PS51420
Domain	Kelch_1	KBTBD2 KLHL18 HCFC1	3.25e-03	70	79	3	PF01344
Domain	Kelch_1	KBTBD2 KLHL18 HCFC1	3.25e-03	70	79	3	IPR006652
Domain	-	EPHB4 EPHA1 EPHB1	3.66e-03	73	79	3	2.60.120.260
Pubmed	Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.	SLC6A8 STK39 OXSR1	1.22e-08	3	81	3	25531585
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	RHOBTB1 PDIK1L GRK7 MAP3K9 TSSK3 ZC3H7B EPHA1 CDK4 EPHB1	2.20e-07	372	81	9	22939624
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	STAG1 MTOR POLE SMARCA1 CHD4 OXSR1 ZC3H7B SEC61A1 HCFC1 TOP2B CDK4	7.26e-07	704	81	11	29955894
Pubmed	Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.	MTOR STK39 OXSR1	2.64e-06	12	81	3	27782176
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHB4 EPHA1 EPHB1	4.35e-06	14	81	3	26941654
Pubmed	Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers.	STK39 OXSR1	5.36e-06	2	81	2	23034389
Pubmed	Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome.	SEC61A2 SEC61A1	5.36e-06	2	81	2	18480044
Pubmed	Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival.	EPHB4 EPHB1	5.36e-06	2	81	2	24121831
Pubmed	The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.	MAP3K9 MAP3K10	5.36e-06	2	81	2	11416147
Pubmed	Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.	STK39 OXSR1	5.36e-06	2	81	2	24191005
Pubmed	Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform.	SLK STK39	5.36e-06	2	81	2	17321610
Pubmed	Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.	STK39 OXSR1	5.36e-06	2	81	2	16382158
Pubmed	DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting.	MTOR DEPDC5	5.36e-06	2	81	2	36044864
Pubmed	DEPDC5 mutations in familial and sporadic focal epilepsy.	MTOR DEPDC5	5.36e-06	2	81	2	28170089
Pubmed	The Ste20 kinases SPAK and OSR1 travel between cells through exosomes.	STK39 OXSR1	5.36e-06	2	81	2	27122160
Pubmed	SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.	STK39 OXSR1	5.36e-06	2	81	2	26584301
Pubmed	Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.	MAP3K9 MAP3K10	5.36e-06	2	81	2	8477742
Pubmed	Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.	MAP3K9 MAP3K10	5.36e-06	2	81	2	8536694
Pubmed	Circumvent hesitancy between CDK4/6 and mTOR inhibitors in second-line treatment of HR+, erb2- metastatic breast cancer.	MTOR CDK4	5.36e-06	2	81	2	28685610
Pubmed	Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations.	MTOR DEPDC5	5.36e-06	2	81	2	24585383
Pubmed	Role of the WNK-activated SPAK kinase in regulating blood pressure.	STK39 OXSR1	5.36e-06	2	81	2	20091762
Pubmed	Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT).	AWAT2 DGAT2L6	5.36e-06	2	81	2	20374941
Pubmed	SPAK and OSR1 Sensitive Kir2.1 K+ Channels.	STK39 OXSR1	5.36e-06	2	81	2	26673921
Pubmed	Regulation of NKCC2 activity by SPAK truncated isoforms.	STK39 OXSR1	5.36e-06	2	81	2	24173353
Pubmed	Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.	EPHB4 EPHA1 EPHB1	8.08e-06	17	81	3	12217323
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPHB4 SLC6A8 CDC42BPA NUP85 MTOR POLE DYRK1A IRAK1 DEPDC5 KAZALD1 ZC3H7B HCFC1	9.37e-06	1105	81	12	35748872
Pubmed	Multiple roles of EPH receptors and ephrins in neural development.	EPHB4 EPHA1 EPHB1	1.35e-05	20	81	3	11256076
Pubmed	The ephrins and Eph receptors in neural development.	EPHB4 EPHA1 EPHB1	1.35e-05	20	81	3	9530499
Pubmed	Eph receptors and ephrins: effectors of morphogenesis.	EPHB4 EPHA1 EPHB1	1.35e-05	20	81	3	10207129
Pubmed	The Eph family receptors and ligands.	EPHB4 EPHA1 EPHB1	1.35e-05	20	81	3	9576626
Pubmed	Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.	EPHB4 EPHA1 EPHB1	1.57e-05	21	81	3	9267020
Pubmed	Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.	EPHB4 EPHA1 EPHB1	1.57e-05	21	81	3	10495276
Pubmed	Developmental expression of Eph and ephrin family genes in mammalian small intestine.	EPHB4 EPHA1 EPHB1	1.57e-05	21	81	3	20112066
Pubmed	Roles of Eph receptors and ephrins in segmental patterning.	EPHB4 EPHA1 EPHB1	1.57e-05	21	81	3	11128993
Pubmed	Eph receptors and ephrins: regulators of guidance and assembly.	EPHB4 EPHA1 EPHB1	1.57e-05	21	81	3	10730216
Pubmed	Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.	STK39 OXSR1	1.60e-05	3	81	2	34726826
Pubmed	Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke.	STK39 OXSR1	1.60e-05	3	81	2	26861815
Pubmed	SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.	STK39 OXSR1	1.60e-05	3	81	2	27068441
Pubmed	Regulation of ClC-2 activity by SPAK and OSR1.	STK39 OXSR1	1.60e-05	3	81	2	25323061
Pubmed	Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.	MAP3K9 MAP3K10	1.60e-05	3	81	2	18414056
Pubmed	Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation.	EPHB4 MTOR	1.60e-05	3	81	2	22684558
Pubmed	SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.	STK39 OXSR1	1.60e-05	3	81	2	22977235
Pubmed	Molecular components of signal amplification in olfactory sensory cilia.	STK39 OXSR1	1.60e-05	3	81	2	20231443
Pubmed	The Dictyostelium discoideum family of Rho-related proteins.	RHOBTB1 RHOBTB2	1.60e-05	3	81	2	11222756
Pubmed	Completing the structural family portrait of the human EphB tyrosine kinase domains.	EPHB4 EPHB1	1.60e-05	3	81	2	24677421
Pubmed	WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.	STK39 OXSR1	1.60e-05	3	81	2	16263722
Pubmed	Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma.	MTOR CDK4	1.60e-05	3	81	2	30084835
Pubmed	OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis.	STK39 OXSR1	1.60e-05	3	81	2	27853306
Pubmed	Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.	STK39 OXSR1	1.60e-05	3	81	2	18270262
Pubmed	Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.	RHOBTB1 RHOBTB2	1.60e-05	3	81	2	27314390
Pubmed	Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease.	MTOR CDK4	1.60e-05	3	81	2	34230123
Pubmed	EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.	EPHB4 EPHB1	1.60e-05	3	81	2	15722342
Pubmed	SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.	STK39 OXSR1	1.60e-05	3	81	2	24039833
Pubmed	STK39 is an independent risk factor for male hypertension in Han Chinese.	STK39 OXSR1	1.60e-05	3	81	2	20889219
Pubmed	SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3.	STK39 OXSR1	1.60e-05	3	81	2	26112741
Pubmed	Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.	MTOR CDK4	1.60e-05	3	81	2	30696953
Pubmed	Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.	STK39 OXSR1	1.60e-05	3	81	2	25515571
Pubmed	Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1.	STK39 OXSR1	1.60e-05	3	81	2	26506223
Pubmed	Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.	RHOBTB1 RHOBTB2	1.60e-05	3	81	2	12426103
Pubmed	SPAK and OSR1 kinases bind and phosphorylate the β2-Adrenergic receptor.	STK39 OXSR1	1.60e-05	3	81	2	32828531
Pubmed	Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.	MAP3K9 MAP3K10	1.60e-05	3	81	2	8195146
Pubmed	The Ste20 kinases Ste20-related proline-alanine-rich kinase and oxidative-stress response 1 regulate NKCC1 function in sensory neurons.	STK39 OXSR1	1.60e-05	3	81	2	19307180
Pubmed	Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.	EPHB4 EPHA1 EPHB1	2.08e-05	23	81	3	19542359
Pubmed	Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.	EPHB4 EPHA1 EPHB1	2.38e-05	24	81	3	16446123
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	NUP85 STAG1 KDM5A POLE SMARCA1 DYRK1A CHD4 HCFC1 TOP2B SMYD2	3.03e-05	857	81	10	25609649
Pubmed	Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily.	AWAT2 DGAT2L6	3.20e-05	4	81	2	15671038
Pubmed	Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.	STK39 OXSR1	3.20e-05	4	81	2	21486947
Pubmed	Ephrin-B stimulation of calvarial bone formation.	EPHB4 EPHB1	3.20e-05	4	81	2	23129351
Pubmed	Down-Regulation of Excitatory Amino Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1.	STK39 OXSR1	3.20e-05	4	81	2	26233565
Pubmed	Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride.	STK39 OXSR1	3.20e-05	4	81	2	25565204
Pubmed	SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1.	STK39 OXSR1	3.20e-05	4	81	2	25322850
Pubmed	Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.	STK39 OXSR1	3.20e-05	4	81	2	25362046
Pubmed	The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.	SEC61A2 SEC61A1	3.20e-05	4	81	2	10212142
Pubmed	Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.	STK39 OXSR1	3.20e-05	4	81	2	16669787
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	RHOBTB1 SAMD8 OXSR1 TSSK3 EPHA1 CDK4	3.35e-05	260	81	6	15761153
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	EPHB4 EPHA1 EPHB1	3.82e-05	28	81	3	18593464
Pubmed	Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.	RHOBTB1 RHOBTB2	5.33e-05	5	81	2	18835386
Pubmed	Sites of regulated phosphorylation that control K-Cl cotransporter activity.	STK39 OXSR1	5.33e-05	5	81	2	19665974
Pubmed	The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function.	MTOR DEPDC5	5.33e-05	5	81	2	38411613
Pubmed	Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.	STK39 OXSR1	5.33e-05	5	81	2	19008908
Pubmed	Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation.	CDK16 CDK4	5.33e-05	5	81	2	8601034
Pubmed	Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.	STK39 OXSR1	5.33e-05	5	81	2	18800028
Pubmed	Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.	STK39 OXSR1	5.33e-05	5	81	2	24808538
Pubmed	A SPAK isoform switch modulates renal salt transport and blood pressure.	STK39 OXSR1	5.33e-05	5	81	2	21907141
Pubmed	Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.	SEC61A2 SEC61A1	5.33e-05	5	81	2	9565615
Pubmed	WNK kinases sense molecular crowding and rescue cell volume via phase separation.	STK39 OXSR1	5.33e-05	5	81	2	36318922
Pubmed	Dyrk1a Mutations Cause Undergrowth of Cortical Pyramidal Neurons via Dysregulated Growth Factor Signaling.	MTOR DYRK1A	5.33e-05	5	81	2	33840455
Pubmed	Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.	TLR10 IRAK1	5.33e-05	5	81	2	16537705
Pubmed	Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.	STK39 OXSR1	7.99e-05	6	81	2	21321328
Pubmed	Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress.	SEC61A2 SEC61A1	7.99e-05	6	81	2	16705175
Pubmed	Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases.	AWAT2 DGAT2L6	7.99e-05	6	81	2	28420705
Pubmed	MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.	RHOBTB1 RHOBTB2	7.99e-05	6	81	2	22709582
Pubmed	MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.	STK39 OXSR1	7.99e-05	6	81	2	21423148
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	SEC61A2 MTOR POLE SMARCA1 DYRK1A IRAK1 SEC61A1 CDK4	8.54e-05	606	81	8	36538041
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	RHOBTB1 RHOBTB2 KLHL18 TMEM63A	9.39e-05	101	81	4	9872452
Pubmed	Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors.	EPHB4 EPHB1	1.12e-04	7	81	2	8954633
Pubmed	RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina.	NDUFB8 HCFC1 CDK4	1.31e-04	42	81	3	26876175
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	SMARCA1 CHD4 TOP2B	1.40e-04	43	81	3	26030138
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	MTOR RERE HCFC1	1.40e-04	43	81	3	33472061
Pubmed	mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.	MTOR CDK4	1.49e-04	8	81	2	29275959
Interaction	CDC37 interactions	EPHB4 HSP90AB4P MTOR PDIK1L GRK7 RHOBTB2 MAP3K10 IRAK1 SMYD2 EPHA1 CDK4 PLCE1 EPHB1	1.07e-06	645	78	13	int:CDC37
Interaction	FKBP5 interactions	EPHB4 NUP85 HSP90AB4P PDIK1L POLE IRAK1 HCFC1 TOP2B CDK4 PLCE1	4.35e-06	414	78	10	int:FKBP5
Interaction	HSP90AA1 interactions	RHOBTB1 HSP90AB4P MTOR PDIK1L GRK7 RHOBTB2 MAP3K9 MAP3K10 IRAK1 TSSK3 ZC3H7B HCFC1 SMYD2 EPHA1 CDK4 PLCE1 EPHB1	5.21e-06	1263	78	17	int:HSP90AA1
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB4 EPHA1 EPHB1	7.99e-06	14	52	3	1095
GeneFamily	Sterile alpha motif domain containing	EPHB4 SAMD8 EPHA1 EPHB1	1.19e-04	88	52	4	760
GeneFamily	Diacylglycerol O-acyltransferase 2 family	AWAT2 DGAT2L6	2.25e-04	8	52	2	1235
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	RHOBTB1 RHOBTB2 KBTBD2 KLHL18	5.93e-04	134	52	4	861
GeneFamily	Rho family GTPases	RHOBTB1 RHOBTB2	1.49e-03	20	52	2	390
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K9 MAP3K10	2.15e-03	24	52	2	654
GeneFamily	Cyclin dependent kinases	CDK16 CDK4	2.52e-03	26	52	2	496
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	SLC6A8 TTC39B ARSL POLE HCFC1 EPHA1	1.12e-06	185	81	6	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pre-B\|bone_marrow / Manually curated celltypes from each tissue	TLR10 DPY19L3 EMP2 NIBAN3 PLCE1	1.17e-05	162	81	5	e088e66aabc307dde5d2b9aa295c34ef68155b1a
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAMD8 CHD4 RERE NIBAN3 KLHL18	1.20e-05	163	81	5	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAMD8 CHD4 RERE NIBAN3 KLHL18	1.60e-05	173	81	5	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 MGAM PKD1L2 UNC80 PLCE1	2.16e-05	184	81	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 MGAM PKD1L2 UNC80 PLCE1	2.16e-05	184	81	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNTL6 MGAM PKD1L2 UNC80 PLCE1	2.16e-05	184	81	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MACC1 ABHD2 MAP3K9 STK39 EMP2	2.39e-05	188	81	5	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	DPY19L2 ABHD2 GPAT3 STARD7 SMYD2	2.45e-05	189	81	5	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAT2 RHOBTB2 OXSR1 EMP2 PLCE1	2.71e-05	193	81	5	a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TLR10 GALNTL6 RHOBTB2 NIBAN3 PLCE1	2.78e-05	194	81	5	2b61023a602d336ed0de174e9141046173db34e6
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TLR10 GALNTL6 RHOBTB2 NIBAN3 PLCE1	2.78e-05	194	81	5	f2486b19ac52a48d19f80b38a5536bee3dad745b
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	STAG1 DYRK1A STK39 RERE VPS13B	2.92e-05	196	81	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	KCNT2 PI4KAP2 FBXO21 SLC4A5 PLCE1	2.92e-05	196	81	5	7e98380d815fbf6254289ace2af37aac6fef51e8
ToppCell	3'-Adult-SmallIntestine\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TLR10 MGAM MALRD1 TM4SF18 NIBAN3	2.99e-05	197	81	5	1614bc5f41fd2c8385e58ed6b87ef1536421f29a
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-B-B_intermediate\|COVID-19_Mild / Disease, condition lineage and cell class	TLR10 GALNTL6 RHOBTB2 NIBAN3 PLCE1	3.14e-05	199	81	5	1c6a08d01f6c1a2a4b6587d3a4522efbd03275e1
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	STAG1 DYRK1A STK39 RERE VPS13B	3.14e-05	199	81	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Computational	Response to DNA damage.	CDK16 POLE DYRK1A IRAK1 CHD4 NME4 CDK4 EPHB1	1.27e-06	187	47	8	MODULE_244
Drug	Hycanthone [3105-97-3]; Down 200; 11.2uM; HL60; HG-U133A	CDK16 MGAM CDC42BPA STAG1 RERE ZC3H7B VPS13B	4.32e-06	187	80	7	1614_DN
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; PC3; HT_HG-U133A	EPHB4 CDC42BPA ABHD2 KAZALD1 RERE ZC3H7B TMEM63A	5.50e-06	194	80	7	3758_DN
Disease	Metastatic melanoma	EPHB4 MTOR GRK7 MAP3K9 MAP3K10 OXSR1	7.64e-09	54	80	6	C0278883
Disease	developmental and epileptic encephalopathy 64 (implicated_via_orthology)	RHOBTB1 RHOBTB2	7.26e-06	2	80	2	DOID:0070375 (implicated_via_orthology)
Disease	1,5 anhydroglucitol measurement	MGAM PKD1L2 MGAM2	6.66e-05	29	80	3	EFO_0008009
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	NUP85 EMP2 PLCE1	7.39e-05	30	80	3	C1868672
Disease	intellectual disability (is_implicated_in)	SLC6A8 IMPA1 DYRK1A	7.39e-05	30	80	3	DOID:1059 (is_implicated_in)
Disease	cancer (implicated_via_orthology)	HSP90AB4P MTOR POLE DEPDC5 TOP2B CDK4	9.09e-05	268	80	6	DOID:162 (implicated_via_orthology)
Disease	Gastric Adenocarcinoma	EPHB4 MAP3K9 EPHB1	2.51e-04	45	80	3	C0278701
Disease	response to angiotensin-converting enzyme inhibitor, Cough	GALNTL6 PKD1L2 VPS13B	2.68e-04	46	80	3	EFO_0005325, HP_0012735
Disease	4-vinylphenol sulfate measurement	ARSL EPHB1	3.22e-04	10	80	2	EFO_0021149
Disease	optic cup area measurement	CDC42BPA RERE PLCE1	4.80e-04	56	80	3	EFO_0006940
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5A DYRK1A	8.50e-04	16	80	2	DOID:0050888 (implicated_via_orthology)
Disease	Rolandic epilepsy	DPY19L2 GK5	8.50e-04	16	80	2	Orphanet_1945
Disease	response to acetylsalicylate	KLHL18 EPHB1	8.50e-04	16	80	2	GO_1903492
Disease	ankylosing spondylitis (is_implicated_in)	KDM5A IRAK1	1.20e-03	19	80	2	DOID:7147 (is_implicated_in)
Disease	Intellectual Disability	SLC6A8 CDK16 STAG1 KDM5A MTOR RHOBTB2	1.37e-03	447	80	6	C3714756
Disease	feeling nervous measurement	MGAM STAG1 ZC3H7B	1.73e-03	87	80	3	EFO_0009597
Disease	neurotic disorder	STAG1 RERE ZC3H7B	2.64e-03	101	80	3	EFO_0004257

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEPCMAEEVCSMSWY	CATSPERG	156	Q6ZRH7
MWEVLSFGDKPYGEM	EPHA1	816	P21709
YGMPFSLMGDCARWE	ARSL	171	P51690
MFTYGCTWEFGAMVN	ABHD2	176	P08910
CYKFWPGMMDELSEL	DPY19L3	536	Q6ZPD9
MPYDLAIDMWSLGCI	DYRK1A	336	Q13627
PAMVTLACMDTWVYE	OR2L3	181	Q8NG85
EVYSFGEMPWDLALM	NIBAN3	421	Q86XR2
CWMAPEVMEQVRGYD	OXSR1	191	O95747
QMSCEMWDFDIYGDL	DEPDC5	176	O75140
GIVMWEVMSFGERPY	EPHB1	811	P54762
YNCVIYGWDPTCMMG	FBXO21	516	O94952
KMYVFGGWVPLVMDD	HCFC1	266	P51610
MSAAGTYAWMAPEVI	MAP3K10	261	Q02779
FGCEVFAYPMASIEW	KAZALD1	191	Q96I82
YGIVMWEVMSFGERP	EPHB4	806	P54760
MCVRWMQLGAFYPFS	MGAM2	1521	Q2M2H8
WIMDSFDDLMPEYVG	HSP90AB4P	311	Q58FF6
EMCVRWMQLGAFYPF	MGAM	1566	O43451
YEMCVRWMQLGAFYP	MGAM	2461	O43451
TWSSEEMVYPGGAMV	FAT2	4166	Q9NYQ8
NQMYFDWGPGEMLVC	NUP85	21	Q9BW27
PAMVTLACMDTWVYE	OR2L8	181	Q8NGY9
CYFPRSDSWVEMAMR	KBTBD2	441	Q8IY47
WYSMEMAGIVCFTGA	POLE	826	Q07864
DMHFLDAICWFPMVY	KCNT2	761	Q6UVM3
DAICWFPMVYYMVGS	KCNT2	766	Q6UVM3
FLAFMIFMCWVGDVY	NDUFB8	136	O95169
EFGAMYAWMLCVFTV	TMEM63A	606	O94886
EVIIASWYCTFMGIM	DPY19L2	196	Q6NUT2
EVPPWVMCRFYKVMD	IRAK1	21	P51617
MKVPWLYVGMCFSSF	KDM5A	466	P29375
MGEDSPVAMFSWYLD	PKD1L2	686	Q7Z442
GMCTVRFWFYMIDPR	MALRD1	1806	Q5VYJ5
AWVAFACTFISGMMY	EMP2	146	P54851
VEMYDPETDCWTFMA	KLHL18	541	O94889
WMPFLREYVMSTGAC	AWAT2	146	Q6E213
AIVCDVWYMPPMTRE	GPAT3	361	Q53EU6
TQIDMWGVGCIFYEM	CDK16	341	Q00536
YATPVDMWSVGCIFA	CDK4	191	P11802
WIPIVREYVMSMGVC	DGAT2L6	146	Q6ZPD8
TGDVAVEMMWKPAYD	MACC1	776	Q6ZN28
MFGVPWPEDMECSRF	FZD3	116	Q9NPG1
GLFDPYKMCWSGMIT	GK5	221	Q6ZS86
PVDWFAMGCSIYEMV	GRK7	371	Q8WTQ7
MWAPDMYVVTYVGDK	CHD4	796	Q14839
KMSAAGTYAWMAPEV	MAP3K9	306	P80192
WDSMEEYTCMIPRDT	MTOR	1526	P42345
QYEISFKVWMCGGEM	GALNTL6	341	Q49A17
IGTPYWMAPEVVMCE	SLK	191	Q9H2G2
FGIMSSDSADPFYWM	SEC61A2	51	Q9H9S3
DEMMPGEWDVCVTSY	SMARCA1	276	P28370
TDVWSLGCVLYAMMF	STK16	216	O75716
FMWVYDEDVGMNCRE	TOP2B	81	Q02880
EVMMVGWSDSYTCEY	TLR10	541	Q9BXR5
MPFSMVRTVESCWYF	TAAR6	86	Q96RI8
FAMTEVCGMILCYIW	SAMD8	201	Q96LT4
MQILSSWFPEEGYMG	PLCE1	2091	Q9P212
MADPWQECMDYAVTL	IMPA1	1	P29218
MSSGPVVAMVWEGYN	NME4	101	O00746
MCLFMAPFETYSTWA	GPR182	201	O15218
WFVMDFCDGGDMNEY	PDIK1L	116	Q8N165
SCDWMAAMFGGPFVE	RHOBTB2	521	Q9BYZ6
LMETMWTYNLAFCGP	OR5M8	156	Q8NGP6
WVYGADRFMDDIACM	SLC6A8	496	P48029
SCEWMAAMFGGSFVE	RHOBTB1	506	O94844
LVWMPGVNDCDLLMY	RERE	316	Q9P2R6
EATPFKWFMEMCVQA	PI4KAP2	496	A4QPH2
WSLGVCMYEMLYGET	CDC42BPA	266	Q5VT25
PALEMMYVWNGFSIV	TTC39B	536	Q5VTQ0
IMYFVRTPCEWGMDA	UNC80	1936	Q8N2C7
YVWYFEGICFSGIMM	TM4SF18	46	Q96CE8
FGIMSSDSADPFYWM	SEC61A1	51	P61619
GDVWSMGVVLYVMLC	TSSK3	191	Q96PN8
MALCSFMGLPWYVAA	SLC4A5	881	Q9BY07
CIEEIGVWMKMYSDA	STAG1	311	Q8WVM7
FYNETEDCPGMMLWR	VPS13B	2326	Q7Z7G8
WMFFVGLVCYMGTFP	SPTY2D1OS	6	A0A0U1RRN3
YCVSWMVSSGMPDFL	STARD7	301	Q9NQZ5
AMGVCLYMQDWEGAL	SMYD2	346	Q9NRG4
PCWMAPEVMEQVRGY	STK39	236	Q9UEW8
DPLLYMTEWFMCAFS	TBC1D10A	266	Q9BXI6
MPTDYADIMMGYHCW	ZC3H7B	831	Q9UGR2
VADPWGGSYMMECLT	MMUT	421	P22033