Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DOCK10 ARFGEF3 FGD4 GNA13 SBF2	4.20e-05	231	34	5	GO:0005085
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF444 ZKSCAN7 ZSCAN2 RFX2 ZSCAN23 ESR1 STAT3 ZNF829 ZSCAN18	1.74e-04	1244	34	9	GO:0000978
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK10 ARFGEF3 IQGAP2 FGD4 GNA13 SBF2	1.91e-04	507	34	6	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK10 ARFGEF3 IQGAP2 FGD4 GNA13 SBF2	1.91e-04	507	34	6	GO:0030695
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF444 ZKSCAN7 ZSCAN2 RFX2 ZSCAN23 ESR1 STAT3 ZNF829 ZSCAN18	2.05e-04	1271	34	9	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF444 ZKSCAN7 ZSCAN2 RFX2 ZSCAN23 ESR1 STAT3 ZNF829 ZSCAN18	4.48e-04	1412	34	9	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF444 ZKSCAN7 ZSCAN2 RFX2 ZSCAN23 ESR1 STAT3 ZNF829 ZSCAN18	5.70e-04	1459	34	9	GO:0000977
Domain	SCAN	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZSCAN18	4.49e-08	56	33	5	SM00431
Domain	SCAN_BOX	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZSCAN18	5.38e-08	58	33	5	PS50804
Domain	SCAN	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZSCAN18	5.38e-08	58	33	5	PF02023
Domain	SCAN_dom	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZSCAN18	5.38e-08	58	33	5	IPR003309
Domain	Retrov_capsid_C	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZSCAN18	5.87e-08	59	33	5	IPR008916
Domain	C2H2_Znf_fam	ZNF444 ZSCAN18	8.15e-04	24	33	2	IPR027775
Domain	-	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829 ZSCAN18	1.08e-03	679	33	6	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829 ZSCAN18	1.21e-03	694	33	6	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829 ZSCAN18	2.12e-03	775	33	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829 ZSCAN18	2.15e-03	777	33	6	PS00028
Domain	Znf_FYVE_PHD	CHD3 KDM7A FGD4	2.19e-03	147	33	3	IPR011011
Domain	Znf_C2H2-like	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829 ZSCAN18	2.43e-03	796	33	6	IPR015880
Domain	Znf_C2H2	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829 ZSCAN18	2.57e-03	805	33	6	IPR007087
Domain	ZnF_C2H2	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829 ZSCAN18	2.62e-03	808	33	6	SM00355
Domain	Zinc_finger_PHD-type_CS	CHD3 KDM7A	5.87e-03	65	33	2	IPR019786
Domain	zf-C2H2	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829	6.95e-03	693	33	5	PF00096
Domain	PH	DOCK10 FGD4 SBF2	7.57e-03	229	33	3	PF00169
Domain	PHD	CHD3 KDM7A	7.75e-03	75	33	2	PF00628
Domain	Znf_PHD-finger	CHD3 KDM7A	8.57e-03	79	33	2	IPR019787
Domain	TyrKc	FLT1 PTK6	1.05e-02	88	33	2	SM00219
Domain	Tyr_kinase_cat_dom	FLT1 PTK6	1.05e-02	88	33	2	IPR020635
Domain	PHD	CHD3 KDM7A	1.08e-02	89	33	2	SM00249
Domain	Znf_PHD	CHD3 KDM7A	1.12e-02	91	33	2	IPR001965
Domain	ZF_PHD_2	CHD3 KDM7A	1.22e-02	95	33	2	PS50016
Domain	-	COL9A1 LMAN2L	1.22e-02	95	33	2	2.60.120.200
Pathway	REACTOME_CDC42_GTPASE_CYCLE	DOCK10 SCRIB IQGAP2 FGD4 GNA13	8.22e-06	155	26	5	M41808
Pubmed	Folate receptor-targeted RNAi nanoparticles for silencing STAT3 in tumor-associated macrophages and tumor cells.	ESR1 STAT3	9.28e-07	2	34	2	32084593
Pubmed	Novel interactions between ERα-36 and STAT3 mediate breast cancer cell migration.	ESR1 STAT3	9.28e-07	2	34	2	31409371
Pubmed	Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.	STAT3 PTK6	9.28e-07	2	34	2	21741923
Pubmed	Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway.	GNA13 ESR1	9.28e-07	2	34	2	16601072
Pubmed	STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.	STAT3 PTK6	2.78e-06	3	34	2	19393627
Pubmed	IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis.	ESR1 STAT3	2.78e-06	3	34	2	32679107
Pubmed	Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells.	ESR1 STAT3	2.78e-06	3	34	2	19876927
Pubmed	IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L.	DOT1L STAT3	2.78e-06	3	34	2	24816405
Pubmed	Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.	STAT3 PTK6	2.78e-06	3	34	2	20929863
Pubmed	Modulation of SOCS3 Levels via STAT3 and Estrogen-ERαp66 Signaling during Hepatitis E Virus Replication in Hepatocellular Carcinoma Cells.	ESR1 STAT3	2.78e-06	3	34	2	36102649
Pubmed	Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3.	ESR1 STAT3	2.78e-06	3	34	2	11429412
Pubmed	Identification of STAT3 as a specific substrate of breast tumor kinase.	STAT3 PTK6	2.78e-06	3	34	2	16568091
Pubmed	Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.	STAT3 PTK6	2.78e-06	3	34	2	22547065
Pubmed	Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic β-cells.	ESR1 STAT3	2.78e-06	3	34	2	22564979
Pubmed	Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes.	ESR1 STAT3	5.56e-06	4	34	2	21747171
Pubmed	DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha.	ESR1 STAT3	5.56e-06	4	34	2	23874500
Pubmed	TWIST represses estrogen receptor-alpha expression by recruiting the NuRD protein complex in breast cancer cells.	CHD3 ESR1	9.26e-06	5	34	2	22457607
Pubmed	BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells.	ARFGEF3 ESR1	2.59e-05	8	34	2	26052702
Pubmed	HIV-1 upregulates VEGF in podocytes.	FLT1 STAT3	2.59e-05	8	34	2	18443354
Pubmed	Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance.	ESR1 STAT3	2.59e-05	8	34	2	21747168
Pubmed	A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.	ARFGEF3 ESR1	2.59e-05	8	34	2	28555617
Pubmed	Uterine Epithelial Estrogen Receptor-α Controls Decidualization via a Paracrine Mechanism.	ESR1 STAT3	4.15e-05	10	34	2	26241389
Pubmed	Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.	ARFGEF3 ESR1	4.15e-05	10	34	2	24051437
Pubmed	Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.	ESR1 STAT3	4.15e-05	10	34	2	12552091
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	ZKSCAN7 DCAF11 HUWE1 STAT3 ZNF829	4.67e-05	410	34	5	25814554
Pubmed	Charcot-Marie-Tooth Neuropathy Type 4 – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	FGD4 SBF2	5.07e-05	11	34	2	20301641
Pubmed	HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3.	FLT1 STAT3	5.07e-05	11	34	2	20661303
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZKSCAN7 ZSCAN2 RFX2 ESR1 STAT3 ZSCAN18	1.86e-04	877	34	6	20211142
Pubmed	Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.	FLT1 ESR1	2.32e-04	23	34	2	36239412
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ARFGEF3 SCRIB HUWE1 IQGAP2	2.41e-04	313	34	4	38270169
Pubmed	Decidualisation and placentation defects are a major cause of age-related reproductive decline.	ESR1 STAT3	2.74e-04	25	34	2	28874785
Pubmed	The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma.	ESR1 STAT3	3.21e-04	27	34	2	26469385
Pubmed	Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.	FLT1 ESR1 STAT3	3.56e-04	141	34	3	18636124
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	ESR1 STAT3	4.24e-04	31	34	2	32546759
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	HUWE1 STAT3	4.81e-04	33	34	2	26296893
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	HUWE1 LMAN2L NDUFA9 STAT3	5.64e-04	392	34	4	33144569
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	CHD3 HUWE1 SBF2	6.14e-04	170	34	3	23314748
Pubmed	Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome.	FLT1 STAT3	7.79e-04	42	34	2	29438518
Pubmed	RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells.	SCRIB GNA13	9.75e-04	47	34	2	29212245
Interaction	SCAND1 interactions	ZNF444 ZKSCAN7 ZSCAN23 ESR1 ZSCAN18	1.12e-07	70	34	5	int:SCAND1
Interaction	ZSCAN22 interactions	ZNF444 ZKSCAN7 ZSCAN23 ZSCAN18	3.02e-07	34	34	4	int:ZSCAN22
Interaction	ZNF446 interactions	ZNF444 ZKSCAN7 SCRIB ZSCAN23 ZSCAN18	3.56e-07	88	34	5	int:ZNF446
Interaction	TSHR interactions	SCRIB LMAN2L IQGAP2 GNA13 STAT3	5.51e-07	96	34	5	int:TSHR
Interaction	ZSCAN32 interactions	ZNF444 ZKSCAN7 ZSCAN23 ZSCAN18	9.58e-07	45	34	4	int:ZSCAN32
Interaction	ZKSCAN8 interactions	ZNF444 CHD3 SCRIB ZSCAN23 ZSCAN18	2.48e-06	130	34	5	int:ZKSCAN8
Interaction	ZKSCAN1 interactions	ZNF444 CHD3 ZSCAN23 ESR1	4.52e-06	66	34	4	int:ZKSCAN1
Interaction	ZNF592 interactions	CHD3 SCRIB DOT1L ESR1	1.02e-05	81	34	4	int:ZNF592
Interaction	PDCL3 interactions	FBXW4 FLT1 DCAF11 FITM2	2.36e-05	100	34	4	int:PDCL3
Interaction	FAR1 interactions	HUWE1 DOT1L FITM2 ESR1	3.95e-05	114	34	4	int:FAR1
Interaction	CTR9 interactions	CHD3 NFS1 FITM2 ESR1 STAT3	4.19e-05	233	34	5	int:CTR9
Interaction	GRWD1 interactions	FLT1 HUWE1 DOT1L IQGAP2 FITM2 ESR1	4.30e-05	390	34	6	int:GRWD1
Interaction	NHP2 interactions	HUWE1 DOT1L FITM2 ESR1	6.80e-05	131	34	4	int:NHP2
Interaction	TFAM interactions	FLT1 HUWE1 DOT1L NFS1 NDUFA9 ESR1	6.83e-05	424	34	6	int:TFAM
Interaction	SCAF11 interactions	CHD3 DOT1L ESR1 STAT3	7.00e-05	132	34	4	int:SCAF11
Interaction	URB1 interactions	FLT1 HUWE1 DOT1L ESR1	7.64e-05	135	34	4	int:URB1
Interaction	RPP40 interactions	DOT1L FITM2 ESR1	8.64e-05	51	34	3	int:RPP40
Interaction	PPP5C interactions	ARFGEF3 HUWE1 NFS1 GNA13 ESR1	8.72e-05	272	34	5	int:PPP5C
Interaction	EIF2S1 interactions	FLT1 CHD3 HUWE1 DOT1L ESR1	9.34e-05	276	34	5	int:EIF2S1
Interaction	NDUFA13 interactions	HUWE1 NDUFA9 ESR1 STAT3	9.55e-05	143	34	4	int:NDUFA13
Interaction	TECR interactions	HUWE1 DOT1L FITM2 ESR1 PTK6	1.18e-04	290	34	5	int:TECR
Interaction	RFX4 interactions	RFX2 ESR1	1.23e-04	10	34	2	int:RFX4
Interaction	EIF3F interactions	CHD3 HUWE1 DOT1L ESR1 STAT3	1.30e-04	296	34	5	int:EIF3F
Interaction	BAZ1A interactions	FLT1 CHD3 DOT1L ESR1	1.34e-04	156	34	4	int:BAZ1A
Interaction	RACK1 interactions	FLT1 CHD3 DCAF11 HUWE1 DOT1L ESR1 STAT3	1.45e-04	704	34	7	int:RACK1
Interaction	SARNP interactions	CHD3 DOT1L FITM2 ESR1	1.78e-04	168	34	4	int:SARNP
Interaction	ZNF174 interactions	ZNF444 ZSCAN23 ZSCAN18	1.95e-04	67	34	3	int:ZNF174
Interaction	CCT4 interactions	FBXW4 DCAF11 HUWE1 DOT1L ESR1 PTK6	1.98e-04	515	34	6	int:CCT4
Interaction	ZNF24 interactions	ZNF444 ZSCAN23 ESR1 ZSCAN18	2.03e-04	174	34	4	int:ZNF24
Interaction	ATAD3A interactions	CHD3 HUWE1 DOT1L ESR1 PTK6	2.15e-04	330	34	5	int:ATAD3A
Interaction	LAS1L interactions	CHD3 HUWE1 DOT1L ESR1	2.41e-04	182	34	4	int:LAS1L
Interaction	ZKSCAN4 interactions	ZNF444 ZKSCAN7 ZSCAN23	2.73e-04	75	34	3	int:ZKSCAN4
Interaction	PELP1 interactions	CHD3 DOT1L ESR1 STAT3	2.79e-04	189	34	4	int:PELP1
Interaction	ZSCAN30 interactions	ZNF444 ZSCAN23	2.86e-04	15	34	2	int:ZSCAN30
Interaction	LUC7L2 interactions	CHD3 HUWE1 DOT1L ESR1 STAT3	2.94e-04	353	34	5	int:LUC7L2
Interaction	MDN1 interactions	FLT1 CHD3 DOT1L ESR1	3.20e-04	196	34	4	int:MDN1
Interaction	SCAND3 interactions	ZNF444 ZSCAN23	3.27e-04	16	34	2	int:SCAND3
Interaction	PWP1 interactions	FLT1 HUWE1 DOT1L ESR1	3.33e-04	198	34	4	int:PWP1
Interaction	CCT6A interactions	FBXW4 DCAF11 HUWE1 DOT1L ESR1 PTK6	3.42e-04	570	34	6	int:CCT6A
Interaction	CCDC137 interactions	FLT1 CHD3 DOT1L ESR1	3.46e-04	200	34	4	int:CCDC137
Interaction	CCT7 interactions	FBXW4 DCAF11 SCRIB HUWE1 ESR1 PTK6	3.58e-04	575	34	6	int:CCT7
Interaction	ATP2A2 interactions	HUWE1 DOT1L NDUFA9 ESR1 STAT3	3.60e-04	369	34	5	int:ATP2A2
Interaction	BAZ1B interactions	FLT1 CHD3 DOT1L ESR1	3.73e-04	204	34	4	int:BAZ1B
Interaction	BANF1 interactions	FLT1 HUWE1 ESR1 STAT3	3.73e-04	204	34	4	int:BANF1
Interaction	WDR36 interactions	CHD3 DOT1L GNA13 ESR1	4.01e-04	208	34	4	int:WDR36
Interaction	ABCF2 interactions	FLT1 HUWE1 DOT1L ESR1	4.08e-04	209	34	4	int:ABCF2
Interaction	GGNBP2 interactions	DOT1L ESR1	4.16e-04	18	34	2	int:GGNBP2
Interaction	SUPT20H interactions	FITM2 ESR1 STAT3	4.22e-04	87	34	3	int:SUPT20H
Interaction	ZKSCAN7 interactions	ZKSCAN7 ZSCAN23	4.64e-04	19	34	2	int:ZKSCAN7
Interaction	C7orf50 interactions	CHD3 HUWE1 DOT1L ESR1	4.79e-04	218	34	4	int:C7orf50
Interaction	ZNF146 interactions	CHD3 DOT1L ESR1	4.82e-04	91	34	3	int:ZNF146
Interaction	RTRAF interactions	CHD3 HUWE1 DOT1L ESR1	5.13e-04	222	34	4	int:RTRAF
Interaction	COMP interactions	COL9A1 STAT3	5.15e-04	20	34	2	int:COMP
Interaction	POLR2H interactions	HUWE1 DOT1L IQGAP2 ESR1	5.22e-04	223	34	4	int:POLR2H
Interaction	ZNF326 interactions	CHD3 HUWE1 DOT1L ESR1	5.30e-04	224	34	4	int:ZNF326
Interaction	NSA2 interactions	FLT1 CHD3 DOT1L ESR1	5.39e-04	225	34	4	int:NSA2
Interaction	DDX46 interactions	CHD3 HUWE1 DOT1L ESR1	5.58e-04	227	34	4	int:DDX46
Interaction	SFSWAP interactions	CHD3 DOT1L ESR1	5.63e-04	96	34	3	int:SFSWAP
Interaction	SMARCA5 interactions	FLT1 CHD3 HUWE1 DOT1L ESR1	6.15e-04	415	34	5	int:SMARCA5
Interaction	ZNF829 interactions	STAT3 ZNF829	6.25e-04	22	34	2	int:ZNF829
Interaction	SPRR2A interactions	ESR1 PTK6	6.25e-04	22	34	2	int:SPRR2A
Interaction	SMC1A interactions	FLT1 CHD3 HUWE1 DOT1L ESR1	6.35e-04	418	34	5	int:SMC1A
Cytoband	19q13.43	ZNF444 ZSCAN18	1.91e-03	87	34	2	19q13.43
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF444 ZKSCAN7 ZSCAN2 ZSCAN23 ZNF829 ZSCAN18	3.56e-04	718	25	6	28
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK10 FGD4 SBF2	2.79e-03	206	25	3	682
GeneFamily	PHD finger proteins	CHD3 KDM7A	6.82e-03	90	25	2	88
GeneFamily	SH2 domain containing	STAT3 PTK6	8.53e-03	101	25	2	741
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KDM7A HUWE1 GNA13 ESR1 STAT3	2.81e-07	185	34	5	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK10 FLT1 DOT1L FGD4 GNA13	4.04e-07	199	34	5	b0a906586e58009f5ed9272fc29ba28e49c85ee6
ToppCell	COVID-19-Myeloid-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	DOCK10 IQGAP2 FGD4 GNA13	5.95e-06	156	34	4	a07a9096799e4ba663841c70035b4b32c1fda4f9
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CDRT4 DCAF11 FITM2 ZSCAN18	7.78e-06	167	34	4	774f3264318b002d0df5d06d41d645366038d0bf
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK10 FBXW4 ZSCAN2 CHD3	7.97e-06	168	34	4	182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	IQGAP2 FGD4 GNA13 SBF2	1.43e-05	195	34	4	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	COVID-19-Myeloid-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	IQGAP2 FGD4 GNA13 SBF2	1.46e-05	196	34	4	4929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCell	COVID-19-Myeloid\|COVID-19 / group, cell type (main and fine annotations)	IQGAP2 FGD4 GNA13 SBF2	1.52e-05	198	34	4	33f0a919188a67d2a876b52c61a1cec2c9747969
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DOCK10 FLT1 COL9A1 IQGAP2	1.58e-05	200	34	4	7e51715525fdb001b7042b2bfcb9de81ecb5e4ee
Drug	Todralazine hydrochloride [3778-76-5]; Down 200; 14.8uM; PC3; HT_HG-U133A	DCAF11 CD22 GNA13 ESR1 RBBP9 PTK6	4.27e-07	197	34	6	5087_DN
Drug	Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	ZNF444 DCAF11 GNA13 ESR1 RBBP9	1.02e-05	196	34	5	7357_DN
Drug	Indoles	FLT1 TMEM204 ESR1	2.68e-05	39	34	3	ctd:D007211
Drug	atamestane	FLT1 ESR1	4.52e-05	7	34	2	CID000057050
Drug	Zinc Sulfate	FLT1 DOT1L IQGAP2 CD22 ZSCAN23 ESR1 STAT3	9.23e-05	739	34	7	ctd:D019287
Drug	Niclosamide [50-65-7]; Up 200; 12.2uM; PC3; HT_HG-U133A	DOCK10 KDM7A ESR1 ZSCAN18	1.12e-04	168	34	4	4018_UP
Drug	4-hydroxybenzophenone	ESR1 STAT3	1.42e-04	12	34	2	CID000014347
Drug	16, 16-dimethylprostaglandin E2 methyl acetate solution; Up 200; 10uM; PC3; HT_HG-U133A	ZNF444 KDM7A ESR1 PTK6	1.72e-04	188	34	4	6562_UP
Drug	Fludrocortisone acetate [514-36-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	ZSCAN2 CD22 GNA13 ESR1	1.90e-04	193	34	4	3866_DN
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	ZNF444 CHD3 KDM7A PTK6	1.98e-04	195	34	4	1630_UP
Drug	Ciprofibrate [52214-84-3]; Up 200; 13.8uM; PC3; HT_HG-U133A	DOCK10 ZSCAN2 FLT1 ESR1	1.98e-04	195	34	4	5740_UP
Drug	Diphenhydramine hydrochloride [147-24-0]; Up 200; 13.8uM; PC3; HT_HG-U133A	FLT1 CD22 RFX2 PTK6	1.98e-04	195	34	4	7318_UP
Drug	Pempidine tartrate [546-48-5]; Down 200; 13uM; MCF7; HT_HG-U133A	ZSCAN2 KDM7A CD22 ESR1	2.02e-04	196	34	4	3832_DN
Drug	(+,-)-Synephrine [94-07-5]; Down 200; 24uM; MCF7; HT_HG-U133A	ZNF444 GNA13 ESR1 RBBP9	2.02e-04	196	34	4	6798_DN
Drug	Strophanthidin [66-28-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A	ZNF444 ESR1 RBBP9 PTK6	2.02e-04	196	34	4	7182_UP
Drug	Rimexolone [49697-38-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A	ZNF444 DCAF11 ESR1 RBBP9	2.02e-04	196	34	4	3516_DN
Drug	Demeclocycline hydrochloride [64-73-3]; Up 200; 8uM; PC3; HT_HG-U133A	RFX2 ESR1 RBBP9 ZSCAN18	2.02e-04	196	34	4	3706_UP
Drug	Iocetamic acid [16034-77-8]; Up 200; 6.6uM; PC3; HT_HG-U133A	HUWE1 CD22 GNA13 RBBP9	2.02e-04	196	34	4	4600_UP
Drug	Monocrotaline [315-22-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	ZNF444 GNA13 ESR1 RBBP9	2.06e-04	197	34	4	6771_DN
Drug	Dropropizine (R,S) [17692-31-8]; Down 200; 17uM; MCF7; HT_HG-U133A	ZNF444 DCAF11 ESR1 RBBP9	2.10e-04	198	34	4	5531_DN
Drug	nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A	ZSCAN2 KDM7A ESR1 PTK6	2.10e-04	198	34	4	1648_UP
Drug	Rilmenidine hemifumarate [54187-04-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A	CHD3 DCAF11 ESR1 RBBP9	2.10e-04	198	34	4	5532_DN
Drug	Clemastine fumarate [14976-57-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A	CHD3 DCAF11 ESR1 RBBP9	2.10e-04	198	34	4	7443_DN
Drug	Dextromethorphan hydrobromide monohydrate [6700-34-1]; Up 200; 10.8uM; PC3; HT_HG-U133A	DOCK10 FLT1 ESR1 PTK6	2.10e-04	198	34	4	6300_UP
Drug	quercetin dihydrate; Down 200; 1uM; MCF7; HT_HG-U133A_EA	ZNF444 KDM7A ESR1 PTK6	2.10e-04	198	34	4	917_DN
Drug	Flumequine [42835-25-6]; Down 200; 15.4uM; MCF7; HT_HG-U133A	ZNF444 CD22 ESR1 RBBP9	2.10e-04	198	34	4	5529_DN
Drug	Oleandomycin phosphate [7060-74-4]; Down 200; 5uM; PC3; HT_HG-U133A	ZSCAN2 KDM7A DCAF11 GNA13	2.14e-04	199	34	4	4615_DN
Drug	Sulfabenzamide [127-71-9]; Up 200; 14.4uM; PC3; HT_HG-U133A	ZSCAN2 FLT1 CD22 ESR1	2.14e-04	199	34	4	6634_UP
Drug	1skj	FLT1 STAT3	2.56e-04	16	34	2	CID000448585
Drug	annonacin	ESR1 STAT3	2.56e-04	16	34	2	ctd:C053442
Drug	lead stearate	ZKSCAN7 FLT1 HUWE1	2.67e-04	84	34	3	CID000061258
Drug	tyrphostin AG17	FLT1 STAT3	2.90e-04	17	34	2	CID000126295
Drug	PCB 104	FLT1 ESR1	2.90e-04	17	34	2	CID000091662
Drug	3,4,3',4'-tetrachlorobiphenyl	DCAF11 HUWE1 IQGAP2 ESR1 SBF2	5.27e-04	453	34	5	ctd:C028451
Drug	AC1NSYHD	CD22 RBBP9	5.37e-04	23	34	2	CID005319705
Drug	Paclitaxel	FLT1 GNA13 ESR1 RBBP9 STAT3 PTK6	6.18e-04	720	34	6	ctd:D017239
Drug	AC1L3UEY	ZKSCAN7 HUWE1 ESR1	6.37e-04	113	34	3	CID000122342
Drug	94 PU	HUWE1 RBBP9	6.88e-04	26	34	2	CID000023940
Drug	tyrphostin AG 1478	FLT1 ESR1 STAT3	7.96e-04	122	34	3	ctd:C101044
Drug	Aza Compounds	FLT1 TMEM204	8.57e-04	29	34	2	ctd:D001372
Drug	L IL	ZKSCAN7 STAT3	9.80e-04	31	34	2	CID000445571
Drug	Sp 1 (pharmaceutical)	ZNF444 ZKSCAN7 ESR1 STAT3 PTK6	1.24e-03	548	34	5	CID000099040
Drug	11-ketotestosterone	SCRIB ESR1	1.47e-03	38	34	2	CID000104796
Drug	S-ethyl glutathione	ESR1 STAT3	1.47e-03	38	34	2	ctd:C042431
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	KDM7A HUWE1	3.38e-05	8	33	2	DOID:0060309 (implicated_via_orthology)
Disease	Leydig cell tumor (is_marker_for)	FLT1 ESR1	3.38e-05	8	33	2	DOID:2696 (is_marker_for)
Disease	lymphangioleiomyomatosis (is_marker_for)	ESR1 STAT3	7.95e-05	12	33	2	DOID:3319 (is_marker_for)
Disease	Charcot-Marie-Tooth disease type 4	FGD4 SBF2	9.39e-05	13	33	2	cv:C4082197
Disease	Schwartz-Jampel Syndrome, Type 1	FLT1 COL9A1	1.44e-04	16	33	2	C4551479
Disease	Schwartz-Jampel Syndrome	FLT1 COL9A1	1.44e-04	16	33	2	C0036391
Disease	Melnick-Needles Syndrome	FLT1 COL9A1	1.44e-04	16	33	2	C0025237
Disease	Spondyloepiphyseal Dysplasia	FLT1 COL9A1	1.44e-04	16	33	2	C0038015
Disease	Spondyloepiphyseal Dysplasia Tarda, X-Linked	FLT1 COL9A1	1.44e-04	16	33	2	C3541456
Disease	Van Buchem disease	FLT1 COL9A1	1.63e-04	17	33	2	C0432272
Disease	Usual Interstitial Pneumonia	ESR1 STAT3	2.05e-04	19	33	2	C4721509
Disease	Hamman-Rich Disease	ESR1 STAT3	2.05e-04	19	33	2	C4721508
Disease	Dyschondroplasias	FLT1 COL9A1	2.05e-04	19	33	2	C0013366
Disease	Osteochondrodysplasias	FLT1 COL9A1	2.05e-04	19	33	2	C0029422
Disease	Multiple Epiphyseal Dysplasia	FLT1 COL9A1	2.28e-04	20	33	2	C0026760
Disease	Familial Idiopathic Pulmonary Fibrosis	ESR1 STAT3	2.28e-04	20	33	2	C4721952
Disease	Idiopathic Pulmonary Fibrosis	ESR1 STAT3	2.51e-04	21	33	2	C1800706
Disease	platelet measurement	DOCK10 ZNF444 IQGAP2 FGD4	4.08e-04	315	33	4	EFO_0005036
Disease	melanoma (is_marker_for)	FLT1 ESR1	6.27e-04	33	33	2	DOID:1909 (is_marker_for)
Disease	nephroblastoma (is_marker_for)	FLT1 STAT3	6.65e-04	34	33	2	DOID:2154 (is_marker_for)
Disease	Charcot-Marie-Tooth disease	FGD4 SBF2	1.02e-03	42	33	2	cv:C0007959
Disease	nasopharynx carcinoma (is_marker_for)	FLT1 STAT3	1.06e-03	43	33	2	DOID:9261 (is_marker_for)
Disease	immunoglobulin isotype switching measurement	ZSCAN23 STAT3	1.11e-03	44	33	2	EFO_0010128
Disease	leukemia	ESR1 STAT3	1.74e-03	55	33	2	C0023418
Disease	Neoplasm Metastasis	FLT1 ESR1 STAT3	1.82e-03	217	33	3	C0027627
Disease	Atherogenesis	ESR1 STAT3	1.99e-03	59	33	2	C1563937
Disease	Atherosclerosis	ESR1 STAT3	1.99e-03	59	33	2	C0004153
Disease	platelet-derived growth factor BB measurement	PRSS35 DOCK10	2.13e-03	61	33	2	EFO_0008264
Disease	transient cerebral ischemia (implicated_via_orthology)	ESR1 STAT3	2.34e-03	64	33	2	DOID:224 (implicated_via_orthology)
Disease	carcinoma (implicated_via_orthology)	FLT1 SCRIB	2.34e-03	64	33	2	DOID:305 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
IRWVCEEIPDLKLAM	DOT1L	41	Q8TEK3
ELECMRALEERPWAS	CDRT4	51	Q8N9R6
RESIWLPFMETELHC	RBBP9	51	O75884
HTREVLKRLEMCPWE	KDM7A	531	Q6ZMT4
LKRLEMCPWEEDILS	KDM7A	536	Q6ZMT4
CIQHVKRLREMSPLW	NFS1	426	Q9Y697
IWECIDRMHKRSPIF	SBF2	1541	Q86WG5
DRELVHMINWAKRVP	ESR1	351	P03372
ICKVWDRRTMREDDP	DCAF11	331	Q8TEB1
KRAPRWIRDNEVTMC	FGD4	551	Q96M96
KHEWRDCIEVPGVRL	LMAN2L	231	Q9H0V9
MRVLVDAREKLHIPW	GNA13	96	Q14344
SWMLVCDRPEREQLK	HUWE1	76	Q7Z6Z7
EPWITRDKVERMHIT	NDUFA9	311	Q16795
VHKLMLTCWCRDPEQ	PTK6	416	Q13882
PELRRTWLESMAKIH	DOCK10	1696	Q96BY6
MEHLERCEWLLRGTL	FITM2	1	Q8N6M3
LCWGDRMPDKDDIRL	CHD3	26	Q12873
KARPLLHVMRCWSLV	ARFGEF3	1196	Q5TH69
LRTSVRKCVMEWEEP	FBXW4	321	P57775
RKCVMEWEEPHDSTL	FBXW4	326	P57775
QWMLIHCDPLRPRRE	COL9A1	236	P20849
EKWMERIHLNVSERP	CD22	126	P20273
CDPILRWMRSCDHIL	RFX2	436	P48378
EAKRWMEVCLVEELP	IQGAP2	46	Q13576
EETMPWIRSPRHCLI	TEX49	96	A0A1B0GTD5
MLKCIPLWRCNRHVE	SCRIB	1	Q14160
HDMSEEMTIPWCLRR	C12orf4	476	Q9NQ89
RDWLRPEVHTKEQML	ZNF444	46	Q8N0Y2
RWLRPEVHTKEQMLT	ZSCAN2	86	Q7Z7L9
EKPMEIARIVARCLW	STAT3	96	P40763
DFMWHLRKVPRIVSE	PRSS35	26	Q8N3Z0
KEPWMVDRELTRGLC	ZNF829	91	Q3KNS6
HELCRQWLMPEARSK	ZSCAN18	71	Q8TBC5
RELCRWWLMPEVHTK	ZKSCAN7	76	Q9P0L1
LIWNILHKREDCMAP	TMEM204	186	Q9BSN7
QIMLDCWHRDPKERP	FLT1	1131	P17948
ELCHQWLRPEMHTKE	ZSCAN23	71	Q3MJ62